阅读说明：本技术 诱导成骨假体装置及其制造方法 (Induced osteogenesis prosthetic appliance and its manufacturing method ) 是由 秦岭 周泳豪 王佳力 许建坤 于 2018-05-22 设计创作，主要内容包括：本申请公开了一种诱导成骨假体装置。该装置包括具有中空部的固定部以及内嵌在所述固定部的中空部中的诱导成骨物质,其中,在所述固定部的外周上设置有多个孔,所述孔与所述中空部连通。(This application discloses a kind of induced osteogenesis prosthetic appliances.The device includes the induced osteogenesis substance for having the fixed part of hollow portion and being embedded in the hollow portion of the fixed part, wherein multiple holes is provided on the periphery of the fixed part, the hole is connected to the hollow portion.)

1. a kind of induced osteogenesis prosthetic appliance, comprising:

Fixed part has hollow portion；And

Induced osteogenesis substance is embedded in the hollow portion of the fixed part,

Wherein, multiple holes are provided on the periphery of the fixed part, the hole is connected to the hollow portion.

2. induced osteogenesis prosthetic appliance according to claim 1, wherein

The induced osteogenesis substance is that can degrade to discharge the magnesium metal of magnesium ion or magnesium alloy.

3. induced osteogenesis prosthetic appliance according to claim 2, wherein

The induced osteogenesis substance is set as the magnesium bar being embedded in the hollow portion or magnesium needle, and the magnesium bar or magnesium needle can lead to It crosses the multiple hole the magnesium ion is discharged into except the fixed part.

4. induced osteogenesis prosthetic appliance according to claim 2 or 3, wherein

The bottom outlet being connected to the hollow portion is provided in the bottom of the fixed part, so that the magnesium ion passes through the bottom outlet It is discharged into except the fixed part.

5. a kind of dental prosthesis implanted device, comprising:

Induced osteogenesis device according to any one of claim 1 to 4；

Adjacency section is fixed on induced osteogenesis device top；And

Corona is fixed on the induced osteogenesis device by the adjacency section.

6. dental prosthesis implanted device according to claim 5, wherein

The adjacency section is fixed on induced osteogenesis prosthetic appliance top by the internal thread part on the fixed part top.

7. a kind of method for manufacturing induced osteogenesis prosthetic appliance, comprising:

Fixed part is provided；

The inside of the fixed part is arranged to hollow portion；

In the periphery of the fixed part, multiple holes being connected to the hollow portion are set；And

Induced osteogenesis substance is embedded in the hollow portion.

8. according to the method described in claim 7, further include:

The bottom outlet being connected to the hollow portion is set in the bottom of the fixed part.

9. method according to claim 7 or 8, wherein

The induced osteogenesis substance is that can degrade to discharge the magnesium metal of magnesium ion or magnesium alloy.

10. according to the method described in claim 9, wherein, the step of embedded induced osteogenesis substance, includes: in the hollow portion

The induced osteogenesis substance is formed into magnesium bar or magnesium needle；And

The magnesium bar or magnesium needle are inserted into the hollow portion,

Wherein, the magnesium bar or magnesium needle can be by the multiple hole that is connected to the hollow portion and/or the bottom outlets by institute Magnesium ion is stated to be discharged into except the fixed part.

Technical field

This application involves a kind of induced osteogenesis prosthetic appliances, more particularly, to a kind of releasable induced osteogenesis factor Using prosthesis device.The application further relates to a kind of dental prosthesis implanted device and one kind including the induced osteogenesis prosthetic appliance The method for manufacturing the induced osteogenesis prosthetic appliance.

Background technique

In Using prosthesis field, usually carried out by the way that inertia prothesis implant body to be embedded in the bone of related parts of human body Using prosthesis.However, this prothesis implant body is typically only capable to play the fixed effect of physics.In order to keep prothesis implant body firm Admittedly be secured in place, need to make prothesis implant body and interior fix bone that bone fusion occurs.The essence of bone fusion is a kind of Bioprocess, it is meant that form close interface between new bone and prothesis implant body material (such as titanium or bioceramic).So And existing inertia prothesis implant body and interior fix bone take a long time could complete bone fusion.

Therefore, it is necessary to the prothesis implant bodies that bone fusion can be rapidly completed in one kind with interior fix bone.

Summary of the invention

To solve the above-mentioned problems, New born formation can be promoted present applicant proposes one kind and there is the mixing of sufficient intensity Prosthetic appliance.

The one aspect of the application provides a kind of induced osteogenesis prosthetic appliance, which includes the fixation with hollow portion Portion and the induced osteogenesis substance being embedded in the hollow portion of the fixed part, wherein be arranged on the periphery of the fixed part There are multiple holes, the hole is connected to the hollow portion.

According to the application embodiment, the induced osteogenesis substance is that can degrade to discharge the metal of magnesium ion Magnesium or magnesium alloy.

According to the application embodiment, the induced osteogenesis substance is set as the magnesium being embedded in the hollow portion The magnesium ion can be discharged into except the fixed part by stick or magnesium needle, the magnesium bar or magnesium needle by the multiple hole.

According to the application embodiment, the bottom being connected to the hollow portion is provided in the bottom of the fixed part Hole, so that the magnesium ion is discharged into except the fixed part by the bottom outlet.

The another aspect of the application provides a kind of dental prosthesis implanted device.The dental prosthesis implanted device includes as above Induced osteogenesis device described in text, it is fixed on the adjacency section on induced osteogenesis device top and is consolidated by the adjacency section The corona being scheduled on the induced osteogenesis device.

According to the application embodiment, the adjacency section is fixed on by the internal thread part on the fixed part top Induced osteogenesis prosthetic appliance top.

The another aspect of the application provides a kind of method for manufacturing induced osteogenesis prosthetic appliance.This includes: offer fixation Portion；The inside of the fixed part is arranged to hollow portion；In the periphery of the fixed part, setting is multiple is connected to the hollow portion Hole；And induced osteogenesis substance is embedded in the hollow portion.

According to the application embodiment, the method also includes in the bottom of the fixed part is arranged and is described The bottom outlet of empty portion's connection.

According to the application embodiment, the induced osteogenesis substance is that can degrade to discharge the metal of magnesium ion Magnesium or magnesium alloy.

According to the application embodiment, wherein the step of embedding induced osteogenesis substance in the hollow portion is wrapped It includes: the induced osteogenesis substance is formed into magnesium bar or magnesium needle；And the magnesium bar or magnesium needle are inserted into the hollow portion, In, the magnesium bar or magnesium needle can by the multiple hole that is connected to the hollow portion and/or the bottom outlet by the magnesium from Son is discharged into except the fixed part.

Detailed description of the invention

Below in conjunction with attached drawing, the principle of present inventive concept is explained by describing the illustrative embodiments of the application.It answers Work as understanding, attached drawing is intended to show that the illustrative embodiments of the application rather than is limited.Wherein, attached drawing is for offer pair The present application design is further understood, and is incorporated in specification and is formed part of this specification.It is identical in attached drawing Appended drawing reference indicates identical feature.In the accompanying drawings:

Fig. 1 shows the vacation of the induced osteogenesis according to presently filed embodiment in the case where being not inserted into induced osteogenesis material The sectional view of body device；

Fig. 2 shows the induced osteogenesis prosthetic appliances according to presently filed embodiment after being inserted into induced osteogenesis material Sectional view；

Fig. 3 shows the exploded view of the induced osteogenesis prosthetic appliance according to presently filed embodiment of Fig. 2；

Fig. 4 shows the induced osteogenesis prosthese according to presently filed embodiment the case where being not inserted into induced osteogenesis material The modification of device；

Fig. 5 A shows the schematic diagram of prosthetic appliance in a state of use according to prior art；

Fig. 5 B shows the schematic diagram according to the induced osteogenesis prosthetic appliance of presently filed embodiment in a state of use；

Fig. 6 shows the schematic diagram of the dental prosthesis implanted device according to presently filed embodiment；

Fig. 7 shows the exploded view of the dental prosthesis implanted device according to presently filed embodiment of Fig. 6；

Fig. 8 diagrammatically illustrates the replacement process of the dental prosthesis implanted device according to presently filed embodiment；And

Fig. 9 shows the manufacturing method of the induced osteogenesis prosthetic appliance according to presently filed embodiment.

Specific embodiment

The application in order to better understand makes in more detail below with reference to various aspects of the attached drawing to the application It is bright.It should be understood that the only description to the illustrative embodiments of the application is described in detail in these, rather than this is limited in any way The range of application.

Terms used herein are the purposes in order to describe specific exemplary embodiments, and are not intended to and are limited. When used in this manual, term "comprising", " having " and/or " comprising " indicate there are the feature, entirety, element, Component and/or their combination, but it is not excluded that one or more of the other feature, entirety, component, assembly unit and/or they Combined existence.

It is described herein with reference to the schematic diagram of illustrative embodiments.Illustrative embodiments disclosed herein is not answered Be construed as limited to the concrete shape shown and size, but the various equivalent structures including can be realized identical function and by Such as manufacture the shape and size deviation of generation.Position shown in the drawings is substantially schematical, and is not intended to each portion The specific location of part is limited.

Unless otherwise defined, otherwise all terms (including technical terms and scientific terms) used herein have and this public affairs That opens person of an ordinary skill in the technical field is generally understood identical meaning.Term defined in such as common dictionary should be by It is construed to have and its consistent meaning of meaning under the context of related fields, and will be not with idealization or excessively formal Meaning is explained, unless be clearly defined herein.

The various aspects of the application are described in detail below with reference to attached drawing.

Figures 1 and 2 show that according to the schematic sectional of the induced osteogenesis prosthetic appliance 100 of presently filed embodiment Figure.Induced osteogenesis prosthetic appliance 100 may include the fixed part 10 and embedded degradable induced osteogenesis material with hollow portion 12 Material 20.As depicted in figs. 1 and 2, as an example, fixed part 10 is set as with externally threaded screw, and the periphery of fixed part at Type has multiple holes 14.Hole 14 may be configured as being connected to hollow portion 12, with through holes 14 such as the ions that allows induced osteogenesis material 20 The outside of fixed part 12 (i.e. screw) is discharged into from hollow portion 12.

The induced osteogenesis factor of the release of through hole 14 into peripheral bone tissue can promote sensory nerve to regenerate and discharge more The nerve polypeptides (for example, calcitonin gene-related peptide) for promoting bone-forming effects more, thus accelerate bone tissue and prosthetic appliance 100 it Between fusion.

The study found that magnesium surpasses the important coenzyme of 300 kinds of biochemical reactions as a kind of participation human body, contain adult is intracorporal There are about 30 grams for amount.A large amount of newest in vitro and in vivo clinical researches confirm that magnesium ion can promote New born formation.In the implementation In mode, in view of magnesium ion to the facilitation of new bone formation and nerve regneration, induced osteogenesis material 20 can for magnesium metal or Degradable magnesium alloy.The induced osteogenesis material 20 of magnesium ion or magnesium alloy materials is embedded into such as titanium or bioceramic Through-hole is set in the prothesis implant body of manufacture and on prothesis implant body so as to magnesium ion be discharged, to overcome in the prior art Since the mechanical strength of magnesium metal is insufficient, the problem of prothesis implant body can not be used alone as in practical applications.On the other hand, embedding The magnesium ion for entering the degradable magnesium metal in hollow portion 12 or magnesium alloy release can be by multiple holes 14 around fixed part 10 It diffuses in peripheral bone tissue, to accelerate merging for bone tissue and prosthetic appliance 100.

For the ease of installing and using, as induced osteogenesis material 20 magnesium metal or it is magnesium alloy molded for club shaped structure or Acicular texture is shaped to degradable magnesium bar or magnesium needle 20.

Hollow type fixed part 10 can be prepared by traditional medical material (for example, titanium or bioceramic etc.), to ensure prosthese Device 100 has enough mechanical strengths to be fixedly supported prosthese.Fixed part 10 is designed to the porous knot comprising multiple holes 14 Structure so that the induced osteogenesis factor (that is, magnesium ion) that discharges of embedded magnesium bar or U.S. needle 20 can through hole 14 diffuse to week Enclose bone tissue.Once 100 kinds of prosthetic appliance are planted into human body, because of connecing for induction osteogenic materials (that is, magnesium or magnesium needle) and human body fluid Touching will cause it to degrade and then discharge magnesium ion, to be conducive to stimulate the bone uptake around prothesis implant body and nerve regneration.

The shape of fixed part 10 can carry out adaptive change according to concrete application situation and be not limited to screw shown in figure Structure.For example, bottom outlet 15 (as shown in Figure 4) can be arranged in the bottom of fixed part 10 according to the needs of clinical symptoms.In addition, solid Size, arrangement, position, direction and the quantity for determining multiple holes 14 provided around portion 10 can be adjusted as needed without limiting to In as shown in the figure.

For ease of description, it is illustrated by taking dental prosthesis implantation material as an example herein in conjunction with Fig. 2 to Fig. 8.

As dental prosthesis implantation material, fixed part 10 is set as with externally threaded hollow type screw.As shown in figure 8, implantation Position is the jawbone of patient.Threaded portion will be cut in patient's bone tissue to prevent fixed part 10 from falling off from jawbone.In addition, this is fixed Portion 10 also with internal whorl structure 22 in order to fixing teeth prothesis implant body adjacency section (that is, Fig. 6 and shown in Fig. 7 Adjacency section 30) etc..The screw of implantation not only fixing teeth prothesis implant body, hollow structure can also accommodate magnesium bar from mechanics And/or magnesium needle isoreactivity substance is to promote merging for screw and bone tissue.

Fig. 5 A and Fig. 5 B respectively illustrate surrounding bone group before and after being embedded in induced osteogenesis material 20 (magnesium bar/magnesium needle) The variation knitted.

Induced osteogenesis material 20 can be the magnesium bar/magnesium needle being inserted directly into inside screw, but be not limited to these structures.Ability Field technique personnel can change the shape of induced osteogenesis material 20 according to actual needs, for example, induced osteogenesis material 20 can also be The metallic particles etc. containing magnesium ion being contained in screw hollow portion.It is illustrated in this example with bar structure.Bar Chemical component is magnesium or its alloy.

As shown in Figure 5A, existing clinical operation scheme installation artificial tooth is implanted into using the interior fixation implant of similar screw So that freshman bone tissue is gradually filled in the gap between bone and screw in the jawbone of patient.Due to the embodiment in Fig. 5 A In, magnesium bar is not embedded into screw, therefore the not release of magnesium ion, so that calcitonin gene-related peptide can not be discharged to promote Bone and nerve regneration.In contrast, as shown in Figure 5 B, before installation adjacency section 30 (Fig. 6 and Fig. 7 shown in), magnesium bar be can be inserted into Inside screw.The magnesium bar of insertion can gradually degrade under the action of human body fluid and release magnesium ion, and magnesium ion gradually passes through Hole 14 on screw is discharged into bone tissue 102, to promote the bone and sensory nerve in the bone tissue 102 around screw Regeneration, the significant bone fusion and neurotization time shortened between bone and screw.

Magnesium ion promotes the molecule mechanism process of New born formation by the release of up-regulation calcitonin gene-related peptide in Fig. 5 B It is closely related with sensory nerve and periosteum derived stem cell.The process can be described as: (1) magnesium ion can promote sensory nerve release more More calcitonin gene-related peptide；(2) calcitonin gene-related peptide can enhance the Osteoblast Differentiation ability of periosteum derived stem cell； (3) mixing arrangement containing magnesium promotes new bone formation so as to conspicuousness.

Fig. 6 and Fig. 7 is shown including the dental prosthesis according to the induced osteogenesis prosthetic appliance 100 of presently filed embodiment The schematic diagram of implanted device 200.

Dental prosthesis implanted device 200 may include above-mentioned induced osteogenesis device 100, adjacency section 30 and by adjacency section 30 The corona 40 being fixed on prosthetic appliance 100, wherein prosthetic appliance includes fixed part 10 (screw) and induced osteogenesis material 20 (magnesium bar/magnesium needle), adjacency section 30 is fixed on 100 top of prosthetic appliance by the internal thread part on screw top.

When installation, adjacency section 30 is closely closely screwed in screw by internal thread part, to connect corona and screw, thus will Corona 40 is fixed on jawbone.

Fig. 8 is shown in single tooth replacement process, the installation signal of the dental prosthesis implanted device 200 with corona Figure.

As shown in figure 8, adjacency section 30 can be fixed on spiral shell by screwing in the internal thread part of screw after screw placement jawbone Nail on portion.Corona 40 is then fixed on adjacency section 30 by dental cement or Screw or corona 40 can also be with adjacency section 30 are shaped to an entirety.By this method, dental prosthesis implanted device 200 can also pass through the shape of fixed dental bridge or removable artificial tooth Formula fixes multiple tooth Using prosthesis device.

Fig. 9 shows the stream of the method 1000 for manufacturing the induced osteogenesis prosthetic appliance according to presently filed embodiment Cheng Tu.

In step S1002, fixed part 10 is provided, fixed part 10 can be shaped to different structure type as needed, and Fig. 1 is not limited to shape shown in Fig. 8.The inside of fixed part 10 is arranged to hollow structure (step S1004).In step S1006 In, multiple holes 14 are set in the periphery of fixed part, and be connected to multiple holes 14 with above-mentioned hollow structure.Then, among the above Induced osteogenesis substance 20 (step S1008) is inserted into hollow structure.In addition, can also as needed fixed part 10 bottom setting with The bottom outlet 15 of hollow structure connection.

According to the induced osteogenesis prosthetic appliance of presently filed embodiment manufacture with the extension of Implantation Time, inlay can It gradually degrades and releases the rush ostosis factor and especially promote to promote the new bone growth and nerve regneration around fixed part Into the regeneration for secreting relevant sensory nerve to calcitonin gene-related peptide.

It should be appreciated by those skilled in the art that the application other than it can be used for dental field, can also carry out as needed It is modified for use in other Using prosthesis fields.The example that above embodiment is solely for the purpose of illustration and is lifted, rather than For limiting scope of the present application.Scope of the present application will be by the appended claims and its any and all equivalents, packet Any combination of full width for including its feature provides.It is all under teachings of the present application and claims made by appoint What modification, equivalent replacement etc., should be included in this application claims in the range of.