阅读说明：本技术 用于间质激光治疗的设备 (Equipment for interstitial laser therapy ) 是由 C·瓦洛尔 于 2018-03-22 设计创作，主要内容包括：公开了一种用于间质激光治疗的设备。该设备包括围绕中心纵向轴延伸并具有光学输出端的光学波导；光学地耦合到光学输出端、与光学输出端光学地相关联、或定位在光学输出端周围的光学漫射器,其中该光学漫射器包括壳体,该壳体具有用于容纳光学输出端和光学波导的第一纵向部分的开口端；以及被插入、或定位、或位于中心纵向轴和壳体的外表面之间,并优选地在光学波导的第一纵向部分的纵向范围内的温度传感器。光学漫射器可设有一个或多个孔、一个或多个狭缝、一个或多个开口、和/或一个或多个通气孔。该设备还可包括第二温度传感器。还公开了一种用于间质激光治疗的系统。(Disclose a kind of equipment for interstitial laser therapy.The equipment includes extending around center longitudinal axis and having the optical waveguide of optics output end；It is optically coupled to optics output end, or the optical diffuser that is located in optics output end around optically associated with optics output end, wherein the optical diffuser includes shell, which has the open end for accommodating the first longitudinal direction part of optics output end and optical waveguide；And it is inserted into or positions or between center longitudinal axis and the outer surface of shell, and the temperature sensor preferably in the longitudinal extent of the first longitudinal direction part of optical waveguide.Optical diffuser can be equipped with one or more holes, one or more slits, one or more openings, and/or one or more ventholes.The equipment may also include second temperature sensor.Also disclose a kind of system for interstitial laser therapy.)

1. a kind of equipment for interstitial laser therapy, comprising:

Optical waveguide, the optical waveguide extend around center longitudinal axis and have optics output end；

It is optically coupled to the optical diffuser of the optics output end, wherein the optical diffuser includes shell, the shell Body has the open end for accommodating the first longitudinal direction part of the optics output end and the optical waveguide；And

First temperature sensor, first temperature sensor is in the described vertical of the first longitudinal direction part of the optical waveguide Into range, it is inserted between the center longitudinal axis and the outer surface of the shell.

2. equipment as described in claim 1, which is characterized in that first temperature sensor is inserted in the optical waveguide The first longitudinal direction part and the shell between.

3. equipment as claimed in claim 1 or 2, which is characterized in that the shell is tubular shell.

4. equipment as claimed in claim 3, which is characterized in that the outer diameter of the shell is approximately equal to the outer of the optical waveguide Diameter.

5. equipment as claimed in claim 3, which is characterized in that the internal diameter of the shell is approximately equal to the outer of the optical waveguide Diameter.

6. the equipment as described in any one of claims 1 to 5, which is characterized in that the optical diffuser be provided with one or Multiple holes, one or more slits, one or more openings, and/or one or more ventholes.

7. equipment as claimed in claim 6, which is characterized in that the gas generated during use is via one or more of Hole, one or more of slits, one or more of openings, and/or one or more of ventholes are from the optics The interior zone of diffusing globe escapes.

8. the equipment as described in any one of claims 1 to 7, which is characterized in that the shell includes polytetrafluoroethylene (PTFE) (PTFE)。

9. such as equipment described in any item of the claim 1 to 8, which is characterized in that first temperature sensor is microtemperature Sensor.

10. equipment as claimed in any one of claims 1-9 wherein, which is characterized in that first temperature sensor is integrated temperature Spend sensor.

11. the equipment as described in any one of claims 1 to 10, which is characterized in that first temperature sensor is thermoelectricity It is even.

12. the equipment as described in any one of claims 1 to 10, which is characterized in that first temperature sensor is infrared Temperature sensor.

13. the equipment as described in any one of claims 1 to 12, which is characterized in that first temperature sensor is adapted At the first temperature measured outside the optical diffuser.

14. the equipment as described in any one of claims 1 to 13, which is characterized in that the optical waveguide includes internal layer and outer Layer, wherein the outer layer is radially around the internal layer.

15. equipment as claimed in claim 14, which is characterized in that the optical waveguide is optical fiber.

16. equipment as claimed in claim 15, which is characterized in that the internal layer includes sandwich layer and covering, and wherein described Covering is radially around the sandwich layer.

17. the equipment as described in any one of claim 14 to 16, which is characterized in that the optics output end is stripped described Outer layer.

18. equipment as claimed in claim 17, which is characterized in that the optics output end have between about 1mm and about 2mm it Between longitudinal length.

19. the equipment as described in any one of claim 14 to 18, which is characterized in that described the first of the optical waveguide is vertical To the outer layer is partially at least partly peelled off to be used to accommodate first temperature sensor.

20. the equipment as described in any one of claims 1 to 19, which is characterized in that the equipment further comprises being attached to The second temperature sensor of the optical waveguide.

21. equipment as claimed in claim 20, which is characterized in that the second temperature sensor is fixed on the optics wave In the second longitudinal direction part led.

22. the equipment as described in claim 20 or 21, which is characterized in that the second temperature sensor be arranged to adjacent to The open end of the optical diffuser.

23. the equipment as described in any one of claim 20 to 22, which is characterized in that first temperature sensor and described Second temperature sensor vertical misalignment about 4mm to about 6mm.

24. the equipment as described in any one of claim 20 to 23, which is characterized in that first temperature sensor and described Second temperature sensor is adapted to measurement temperature difference.

25. the equipment as described in any one of claim 20 to 24, which is characterized in that the second temperature sensor is adapted At the second temperature measured outside the optical diffuser.

26. the equipment as described in any one of claim 1 to 25, which is characterized in that the center longitudinal axis is not with described One temperature sensor and/or second temperature sensor intersection.

27. the equipment as described in any one of claim 1 to 26, which is characterized in that first temperature sensor and/or institute Second temperature sensor is stated to be oriented to separate with the optics output end.

28. the equipment as described in any one of claim 1 to 27, which is characterized in that first temperature sensor is positioned At the inner surface of the neighbouring or adjacent optical diffuser.

29. the equipment as described in any one of claim 1 to 28, which is characterized in that the second temperature sensor is positioned Except the longitudinal extent of the optical diffuser.

30. a kind of system for interstitial laser therapy, comprising:

Equipment described in any one of claim 1 to 29；

It is optically coupled to the power adjustable light source of the optical waveguide；And

Processing system, the processing system are configured to:

Obtain the measured temperature from first temperature sensor；And

Adjust the Optical output power of the light source.

31. a kind of system for interstitial laser therapy, comprising:

Equipment described in any one of claim 20 to 29；

It is optically coupled to the power adjustable light source of the optical waveguide；And

Processing system, the processing system are configured to:

Obtain the measured temperature from first temperature sensor and from the second temperature sensor；And

Adjust the Optical output power of the light source.

32. the system as described in claim 30 or 31, which is characterized in that the system further comprises for by the equipment It is delivered to the channel for the treatment of region.

33. system as claimed in claim 32, which is characterized in that at least one end in the channel is transparent or semitransparent 's.

34. the system as described in claim 32 or 33, which is characterized in that the channel is conduit or intubation.

35. the system as described in any one of claim 30 to 34, which is characterized in that the system further comprises for fixed The ultrasound scanner of the position equipment.

Technical field:

The present invention relates generally to interstitial laserthermia fields.In further specific example, temperature sensor is formed Or it is provided for a part of the equipment of interstitial laser therapy.

Background

There is optical fiber outstanding guide-lighting performance to become various medical applications in conjunction with compact size and flexibility Ideal chose.

Interstitial laser therapy is the such application of one kind, and wherein light is directed into destination organization to cause local thermotherapy and break The bad tissue interstitial laser therapy can effectively treat lesion and tumour, and especially those are difficult to the disease touched by routine operation Change and tumour.

In depths in patient body, the interstitial technology of progress local thermotherapy provides a kind of safe and efficient for treating cancer Method.Tumour can be contacted via intubation, reduce the invasive of operation to the maximum extent, improved patient comfort, reduced simultaneously Side effect.

The key challenge of interstitial laser therapy is related to that the temperature of target area is monitored and controlled during treatment.Thermotherapy can Destroy the health tissues of tumor tissues and any surrounding.

It has been determined that tissue is heated to 60 DEG C continue that an irreversible cell death can be caused in.At 100 DEG C When, disorganization is at once.In general, the purpose of thermotherapy is to cause local thermotherapy and blood coagulation necrosis in targeted tissue, without Cause to burn.Therefore, during interstitial laser therapy the temperature in continuous monitoring objective region be it is vital, with provide about The Real-time Feedback of target area state.

By means of external computer interface, such as advanced medical imaging devices of magnetic resonance imaging (MRI) scanner etc It can be used for the internal temperature during estimation interstitial laser therapy.However, these equipment are expensive, heavy, and their operation Need a large amount of training.Moreover, the not direct measured value of temperature reading that they are provided, must be pushed away by computer It is disconnected, and possible therefore precision is lower.

Shortage means that current heat treatment unit needs cooling system with most to the feedback rapidly and reliably of tissue temperature The risk of little Hua charred tissue.Example cooling system includes cooling or irrigating catheter.However, these cooling systems increase entrance The whole size of intubation, bigger wound is brought to patient.

Interstitial laser therapy needs new or improved equipment and/or system.

In the present specification to any existing disclosure (or derived information to existing disclosure) or known anything The reference of object is not and should not be taken as and formed to existing disclosure (or derived information to existing disclosure) or known things The confirmation of any type of hint of a part of the common sense in the relevant field of this specification recognizes.

Summary of the invention

This general introduction is provided to introduce the selected works of the concept further described in detailed description below in simplified form. This general introduction is not intended to identify the key features or essential features of theme claimed, is intended to be used to limit required The range of the theme of protection.

According to exemplary aspect, a kind of equipment and/or system for interstitial laser therapy is provided.The equipment is preferably wrapped The optical waveguide with optics output end is included, and is optically coupled to the optical diffuser of optics output end.In an example In form, optical diffuser includes with the shell for accommodating the open end of optics output end.In another exemplary forms, light Learning diffusing globe includes with the shell for accommodating the open end of the longitudinal portion of optical waveguide.Preferably, optical diffuser packet It includes with the shell for accommodating the open end of the longitudinal portion of optics output end and optical waveguide.In another exemplary forms, The equipment includes temperature sensor.Preferably, temperature sensor is inserted into or positions or positioned at the center of optical waveguide longitudinal direction Between axis and the outer surface of shell, and optionally in the longitudinal extent of the longitudinal portion of optical waveguide.

According to an exemplary aspect, a kind of equipment for interstitial laser therapy is provided, comprising: there is optics output end Optical waveguide；Optical diffuser be optically coupled to optics output end or with optics output end it is optically associated or positioning Around optics output end, wherein optical diffuser includes the open end for accommodating optics output end；And temperature sensor Positioned at the inside of the outer surface of optical diffuser.

According to another exemplary aspect, a kind of equipment for interstitial laser therapy is provided, comprising: longitudinal around center Axis extends and has the optical waveguide of optics output end；It is optically coupled to the optical diffuser of optics output end, wherein the light Learning diffusing globe includes shell, which has the open end for accommodating the longitudinal portion of optics output end and optical waveguide；With And temperature sensor, the temperature sensor be inserted in the longitudinal extent of the longitudinal portion of optical waveguide center longitudinal axis and Between the outer surface of shell.

According to another exemplary aspect, a kind of system for interstitial laser therapy is provided, comprising: above-described use In one of interstitial laser therapeutic equipment；It is optically coupled to the power adjustable light source of optical waveguide；And processing system, it should Processing system is configured to: obtaining the measured temperature from temperature sensor；And the optics output work of the adjustment light source Rate.

According to being described below, each example embodiment becomes obviously, to be described below only as at least one unrestricted reality The example for applying example is provided and is described in conjunction with the accompanying.

Fig. 1 instantiates the viewgraph of cross-section of the example apparatus for interstitial laser therapy from front perspective view.

Fig. 2 instantiates the viewgraph of cross-section of the equipment of Fig. 1 from top plan view.

Fig. 3 instantiates the viewgraph of cross-section of the longitudinal portion of the equipment of Fig. 1.

Fig. 4 instantiates the viewgraph of cross-section of the longitudinal portion of the alternative embodiment of the equipment of Fig. 1.

Fig. 5 instantiates the cross-sectional view of the another example apparatus for interstitial laser therapy from front perspective view.

Fig. 6 instantiates the viewgraph of cross-section of the alternative embodiment of the equipment of Fig. 5 from front-side perspective view.

Fig. 7 instantiates the cross-sectional view of the another example apparatus for interstitial laser therapy from front perspective view.

Fig. 8 instantiates the rough schematic view of the equipment of Fig. 7, shows the first temperature sensor and second temperature sensor Various placements.

Fig. 9 instantiates the example system for interstitial laser therapy.

Figure 10 instantiates the exemplary processing system of the system for Fig. 9.

Figure 11 instantiates example optical diffusing globe；

Figure 12 instantiates another example optical diffusing globe；

Figure 13 instantiates another example optical diffusing globe；

Figure 14 instantiates the example system or assembly for interstitial laser therapy；

Figure 15 instantiate for interstitial laser therapy example system or assembly used in example apparatus；

Figure 16 instantiates another example system or assembly for interstitial laser therapy；

Figure 17 instantiates another example system or assembly for interstitial laser therapy；

Figure 18 instantiate for interstitial laser therapy example system or assembly used in example guiding device；

Figure 19 instantiates exemplary sleeve needle part comprising for interstitial laser therapy example system or assembly in The reinforcer (stiffener) and spine used；

Figure 20 instantiates example connector and reinforcer position.

Detailed description

The following mode being merely given as examples is described to provide to the themes of one or more embodiments more precisely Understand.In the accompanying drawings, identical reference label is used to identify identical part in whole attached drawings, and attached drawing, which is included to explain, to be shown The feature of example embodiment.

In the context of the present specification, term " about " is understood to refer to those skilled in the art and is realizing identical function Or it will be considered to a series of numbers for being equal to described value in the context of result.

With reference to Fig. 1 and 2, the example apparatus 100 for interstitial laser therapy is provided.Equipment 100 includes vertical around center Extend and have the optical waveguide 110 of optics output end 112 to axis 120.Output end 112 is the distal end of optical waveguide 110.Equipment 100 further comprise optical diffuser 130, the optical diffuser 130 be optically coupled to output end 112 or with output end 112 Optically it is associated or is located in around output end 112.Diffusing globe 130 includes shell 132 or is made of shell 132, shell 132 have for accommodate output end 112 and preferably also accommodate optical waveguide 110 longitudinal portion 114 open end 134. Shell 132 has outer surface 136, e.g. circumferential outer surface.Equipment 100 further comprises temperature sensor 151.Temperature sensing Device 151 is preferably located in the inside of the outer surface 136 of optical diffuser 130.In one example, temperature sensor 151 is inserted Enter or position or between center longitudinal axis 120 and outer surface 136, in addition, temperature sensor 151 is preferably, but is not Necessarily, it is also inserted into or positions or in the longitudinal extent of the longitudinal portion 114 of optical waveguide 110.

Center longitudinal axis 120 is the vacation centered on the Electromagnetic Wave Propagation main path in optical waveguide 110 or coincided with Think axis.In some instances, optical waveguide 110 include multiple Electromagnetic Wave Propagation paths in the case where, center longitudinal axis 120 with Centered on the center path of Electromagnetic Wave Propagation or coincide with.

Therefore, in one example, a kind of equipment 100 for interstitial laser therapy is provided comprising there is optics The optical waveguide 110 of output end 112.Optical diffuser 130 be optically coupled to optics output end 112 or with optics output end 112 are optically associated or are located in around optics output end 112, and wherein optical diffuser 130 includes defeated for accommodating optics The open end 134 of outlet 112.Temperature sensor 151 is located at the inside of the outer surface 136 of optical diffuser 130.

Center longitudinal axis 120 not with the first temperature sensor 151 (and/or second temperature sensor, if provided, The second temperature sensor 252 of such as Fig. 5) intersection or pass through the first temperature sensor 151 (and/or second temperature sensor, such as If fruit provides, the second temperature sensor 252 of such as Fig. 5) the first temperature sensor 151 (and/or second temperature sensor, If provided, the second temperature sensor 252 of such as Fig. 5) it is positioned to separate with optics output end 112.First temperature passes Sensor 151 can be located near the inner surface of optical diffuser 130 and/or the inner surface of adjacent optical diffuser 130.

Preferably, but not necessarily, optical waveguide 110 is single optical fiber or multiple optical fiber.Suitable optical fiber Example includes silica fibre, but any other materials for being suitable for Electromagnetic Wave Propagation are also possible to suitably, such as titanium dioxide Silicon, fluoride glass, phosphate glass, chalcogenide glass, polymer or any other materials.

The size of optical fiber can change according to the specific application of equipment 100.In one example, optical fiber has about 600 μm Diameter and about 8 ° of the angle of divergence.In other examples, optical fiber can have any other suitable diameter and the angle of divergence.This A little sizes are likely to be dependent on the size of lesion or tumour in need for the treatment of.For example, optical fiber preferably has when treating bigger tumour There are bigger diameter and/or bigger angle of divergence extension, these characteristics because according to, equipment 100 can be in broader region It is upper to realize bigger heat affecting and disorganization.

In other examples, optical waveguide 110 can be the set of any kind of optical waveguide or optical waveguide.Properly Each example of optical waveguide include but is not limited to: it is single mode optical fiber, multimode fibre, the optical cable including one or more optical fiber, flat Surface wave is led and slab waveguide.

Preferably, but not necessarily, optical waveguide 110 can guide have visible light (400nm to 700nm) and/ Or infrared (the electromagnetic wave of wavelength or wave-length coverage in 700nm to 1mm) spectrum.In some instances, optical waveguide 110 is suitble to There is the electromagnetic wave of the wavelength between about 890nm and about 960nm range in guidance.

Optical waveguide 110 includes internal layer 142 and the outer layer 144 radially around internal layer 142.Internal layer 142 is for guiding electromagnetism Wave (such as, it is seen that and/or infra-red radiation), and including sandwich layer and radially around the covering (not shown) of sandwich layer.Outer layer 144 is used In protection internal layer 142 and including protective case.In other examples, optical waveguide 110 can have additional or less layer.Example Such as, optical waveguide 110 may include two or more protection jacket layers or it can be without protection jacket layer.

Output end 112 preferably peels off outer layer 144.This may be advantageous for preventing outer layer 144 to be exposed to electromagnetic radiation , outer layer 144, which is exposed to electromagnetic radiation, may result in the burning of outer layer 144 and damages optical waveguide 110.In some instances, Output end 112 has the longitudinal length of about 1.7mm.That is, optical waveguide 110 extends along from the tip of output end 112 The longitudinal portion of about 1.7mm peels off outer layer 144.In some instances, output end 112 has and extends between about 1mm and about 2mm Longitudinal length.In other examples, the longitudinal portion of output end 112 or output end 112 can be shelled along any other longitudinal length Remove outer layer 144.Alternatively, output end 112 can not peel off outer layer 144 perhaps its can partly peel off outer layer 144 or The radial component of outer layer 144 only can be peelled off or scraped off from output end 112.

The tip of output end 112 or longitudinal end are cut or are polished flat.In other examples, output end 112 can have Have angled tip (that is, being cut at a certain angle relative to longitudinal axis 120), cone point, ball point or any other Geometry or end structure.

Optical waveguide 110 can further comprise optical input port (not shown), be adapted to receive from such as laser Or the electromagnetic wave of the light source output of light emitting diode (LED).Optical input port can be equipped with for exporting with the optics of light source The connector of port coupling.During operation, optics wave is propagated through along its longitudinal axis 120 into the electromagnetic wave of optical input port It leads 110 and is left from output end 112.

Diffusing globe 130 is optically coupled to output end 112 or optically associated with output end 112 or be located in output Around end 112, so that leaving the Electromagnetic Wave Propagation of output end 112 into diffusing globe 130.Enter diffusing globe 130 from output end 112 Electromagnetic wave across shell 132 surface region diffusion, scattering or diffusion.

For the purpose of interstitial laser therapy, the operation of equipment 100 is improved using optical diffuser.Optics is not being used In the case where diffusing globe, the energy of optical waveguide output is generally focused on narrow point.Such high energy concentration can make wave The tissue near output end is led to burn or evaporate.Although generate by this method big thermal damage be it is feasible, gained damage Form is that height is unpredictable and unrepeatable.Optical diffuser uses the energy that optical waveguide is exported across bigger Surface region distribution, thus generate the milder across bigger volume blood coagulation, while minimize or prevent tissue from burning.Light The use for learning diffusing globe allows more consistent and predictable therapeutic process.Moreover, optical diffuser limits optical waveguide tip Denaturation.It protects optical waveguide tip to allow reusable equipment 100, and enhances its safety and accuracy.

In one example, shell 132 is cylindric or tubulose.In other examples, shell 132 can have it is any its His geometry, it is such as coniform.In addition, diffusing globe 130 can be hollow or diffusing globe 130 can further comprise by The scattering material and formation that shell 132 is encapsulated are used to scatter the medium into the electromagnetic wave of diffusing globe 130.

Shell 132 is preferably tubular shell, including open end 134, the closed end and outer surface opposite with open end 134 136.Open end 134 is mechanically coupled to longitudinal portion 114 or fixed to longitudinal portion 114 or is attached to longitudinal portion 114. The longitudinal portion of shell 132 surrounds longitudinal portion 114 and fastens with outer layer 144 or be bonded, clamp or frictionally engage.In In some examples, glue or other fastening mechanism be can be provided that mechanically to couple or fix by shell 132 or be attached to vertical To part 114.

Shell 132 is limited by internal diameter and outer diameter, and internal diameter is the container of shell 132 (that is, for accommodating output end 112 and indulging To the space of part 114) diameter, and outer diameter is the diameter of the outer surface 136 of shell 132.The internal diameter of shell 132 is substantially etc. In the outer diameter of optical waveguide 110.In the case, the outer diameter of shell 132 is greater than the outer diameter of optical waveguide 110, so that diffusing globe 130 project radially outward or protrude relative to optical waveguide 110.

In other examples, the outer diameter of shell 132 is approximately equal to the outer diameter of optical waveguide 110, so that diffusing globe 130 and light Waveguide 110 is learned to flush.In the latter case, the internal diameter of shell 132 is less than the outer diameter of optical waveguide 110.Therefore, longitudinal portion 114 outer layer 144 may need to be scraped off or partially peelled off, to allow longitudinal portion 114 to be received into shell 132. This latter exemplary advantage is that the coupling of diffusing globe 130 and optical waveguide 110 not will increase the diameter of equipment 100.

In another example, the outer diameter of shell 132 can be less than the outer diameter of optical waveguide 110.

Shell 132 is made of translucent material, to allow to be scattered in the electromagnetic radiation in diffusing globe 130 to treated In tissue.Preferably, but not necessarily, shell 132 is by heat proof material (for example, material with low thermal coefficient of expansion) structure At being able to bear up at least about 100 DEG C of temperature or any highest temperature that interstitial laser therapy may need.

Preferably, but not necessarily, shell 132 includes polytetrafluoroethylene (PTFE) (PTFE), also referred to as " Teflon ".Favorably Ground, PTFE can be supreme about 300 DEG C heat-resisting.In other examples, other translucent materials may make up shell 132, such as polycarbonate, Polyurethane, polyethylene, polypropylene, silicon, nylon, PVC, PET, ABS, PES, PEEK, FEP and other flexibilities appropriate or rigid Property, radio (radio-opaque) is opaque or non-radio opaque material.

The optical diffuser made of the heat proof material of such as PTFE etc is advantageous, because it can make directly to be treated Tissue blood coagulation without burning, and it protect optical waveguide tip will not melt or burn during treatment.In addition, resistance to Hot diffusing globe eliminates using cooling system the needs for protecting the integrality of equipment 100.Therefore, equipment 100 do not need include Cooling system.

Temperature sensor 151 is provided for measuring the temperature by equipment 100 by the tissue of interstitial thermotherapy treatment. Therefore, equipment 100 allows to the tumour or group being located at any other position of liver, pancreas, prostate, brain or patient's body Knit carry out laser interstitial thermotherapy for treatment.In addition, equipment 100 allows accurate, direct and rapidly measures treated tumour or tissue Absolute or relative temperature.It can be used for adjusting the radiation that tissue is delivered to by equipment 100 by the temperature reading that temperature sensing 151 provides Amount, and can be used for obtaining or maintaining necessary treatment tissue temperature.

Temperature sensor 151 is inserted into, is inserted radially into or encapsulates or position or is located in center longitudinal axis 120 and shell Between the outer surface 136 of body 132, or at least partly between center longitudinal axis 120 and the outer surface 136 of shell 132.It is preferred that Ground, temperature sensor 151 are also inserted into or position or in the longitudinal extent of the longitudinal portion 114 of optical waveguide 110.In In another example, temperature sensor 151 is located at the inside of the outer surface 136 of optical diffuser 130.Center longitudinal axis 120 not with The intersection of first temperature sensor 151 passes through the first temperature sensor 151.First temperature sensor 151 is positioned to defeated with optics Outlet 112 separate or far from optics output end 112 or abut optics output end 112.First temperature sensor 151 can be located at The inner surface of the neighbouring and/or adjacent optical diffuser 130 of the inner surface of optical diffuser 130.Longitudinal portion 114 is waveguide 110 Longitudinal portion, section or segmentation, be located at shell 132 inside (that is, shell 132 is mechanically coupled to longitudinal portion 114, or it is mechanically coupled at least part of longitudinal portion 114).The length of longitudinal portion 114 can be according to shell 132 Internal structure and change, longitudinal portion 114 is accommodated in shell 132.Preferably, but not necessarily, longitudinal portion 114 is straight It connects adjacent or close to output end 112.In some instances, longitudinal portion 114 from the output end 112 for peelling off outer layer 144 a bit Extend.

In some instances, the length of longitudinal portion 114 is about 5mm, it means that from the output end for peelling off outer layer 144 The distance of the point of optical waveguide 110 near 112 end to open end 134 is about 5mm.In other examples, longitudinal portion 114 length is about 3mm or about 4mm or about 6mm or about 7mm or about 8mm.In other examples, the length of longitudinal portion 114 Degree is between about 1mm and about 10mm.In other examples, the length of longitudinal portion 114 is between about 2mm and about 8mm.At other In example, the length of longitudinal portion 114 is between about 3mm and about 7mm.In other examples, the length of longitudinal portion 114 is about Between 4mm and about 6mm.In other examples, longitudinal portion 114 can have any suitable length.

Longitudinal portion 114 peels off outer layer 144 at least partly to accommodate temperature sensor 151.Recess, groove or recess It is formed in outer layer 144, and temperature sensor 151 is arranged, is located or positioned in this recess.The cross of longitudinal portion 114 Section view is exemplified in Fig. 3, instantiates the profile of recess for accommodating temperature sensor 151, groove or recess.It can also Using other concave profiles, for example, the concave profile for fitting closely or cooperating with the profile of temperature sensor 151.Show at other In example, temperature sensor 151 is embedded into the outer layer 144 of longitudinal portion 114.

Recess for accommodating temperature sensor 151 can be by etching the part of the outer layer 144 in longitudinal portion 114 or cutting Piece is formed.The depth of recess make the outer layer 144 in temperature sensor 151 and longitudinal portion 114 remaining ribbon contacts or Attachment.In other examples illustrated in Fig. 4, the depth of recess taps the exposed portion of temperature sensor 151 and internal layer 142 Touch or be attached to the expose portion of internal layer 142.For example, temperature sensor 151 can be sudden and violent with the covering of optical waveguide 110 or sandwich layer Dew part contacts or attachment.Recess can therefore shape and being fully etched or peelling off outer layer 144 along the section of longitudinal portion 114 At.In some instances, the depth capacity of recess is about 0.3mm depth.In other examples, the depth capacity of recess is less than about 1mm or about 2mm or any other suitable maximum depth value.

In some instances, 151 useful binders of temperature sensor (such as adhesive based on cyanoacrylate) are viscous It is attached to optical waveguide 110.In other examples, it can be used and temperature sensor 151 firmly fixed or be attached to optical waveguide 110 any other mechanism.

Preferably, but not necessarily, the depth of recess makes temperature sensor 151 not protrude or protrude past optics The outer diameter or external range of waveguide 110.

Preferably, but not necessarily, temperature sensor 151 is microtemperature sensor, or with optical waveguide 110 The temperature sensor for the size that characteristic lateral section size is consistent.In some instances, the characteristic lateral section size of optical waveguide 110 In millimeter or sub-millimeter meter range, such as in about 0.06mm between about 0.1mm.In some instances, temperature sensor 151 is Integrated temperature sensor, including the integrated circuit for measuring temperature.

In some instances, temperature sensor 151 is thermoelectricity occasionally low-grade fever galvanic couple.In other examples, temperature sensor 151 be infrared temperature sensor.In other examples, temperature sensor 151 is can to survey in the case where need not directly contact Measure object temperature fully-integrated MEMS (MEM) thermopile sensor, the TMP006 of such as Texas Instrument or TMP006B infrared thermopile non-contact temperature sensor.In other examples, other kinds of temperature sensor can be used, Such as digital temperature sensor, analog temperature sensor, electronic temperature transmitter, mechanical temperature sensor, thermistor, silicon ribbon The temperature sensor of gap temperature sensor or any other type.

In one example, cable needed for temperature sensor 151 is connected to the operation of temperature sensor 151 or lead 160 (for example, for powering for temperature sensor 151 and/or for transmitting measurement data).Cable 160 is along optical waveguide 110 Extend to reach the operator of operation equipment 100 or system.Preferably, but not necessarily, cable 160 can be fixed optics Waveguide 110 is tangled during the operation of equipment 100 to avoid them.In some instances, fluorine band winding 162 can be by these electricity Cable is fastened to optical waveguide 110.In other examples, other fastening mechanism can be used.

In other examples, temperature sensor 151 is radio temperature sensor, its temperature is transmitted by means of Radio Link Measured value.In some examples, temperature sensor 151 is the radio temperature sensor wirelessly powered.One example wireless temperature Degree sensor is the mixed signal microelectronics group development by Technische Universiteit Eindhoven, and the radio temperature sensor is by sensing Radio wave power supply in the wireless network of device.Other examples of suitable radio temperature sensor can be in the doctor of Hao Gao Paper " fully-integrated ultra low power millimeter wave wireless sensor design method (Fully integrated ultra-low Power mm-wave wireless sensor design methods) " and Hao Gao et al. in Seattle, Washington The paper issued on the seminar of IEEE RF IC (RFIC) for 2013 is " for the wireless temperature sensing in 65nm CMOS The 71GHz RF energy that the efficiency of device is 8% acquires label (A 71GHz RF energy harvesting tag with 8%efficiency for wireless temperature sensors in 65nm CMOS) " in find.403–406. In the example embodiment that temperature sensor 151 is wireless sensor, or in other extra examples of cable 160, cable 160 can be not included in equipment 100.

Preferably, but not necessarily, temperature sensor 151 is adapted to the temperature outside measurement optical diffuser 130. For example, orientation should be set or be arranged in order to detect quilt in the case where temperature sensor 151 is infrared temperature sensor The infrared spectral distribution of the tissue for the treatment of.Alternatively, temperature sensor 151 is adapted to the temperature by measuring optical diffuser 130 To measure the temperature outside optical diffuser 130.For example, optical diffuser 130 may contact or tightly with just treated tissue The nearly just treated tissue of contiguity, in the case, optical diffuser 130 can be generally in thermal balance or quasi- flat with the tissue Weighing apparatus.

Usually, it is undesirable to which temperature sensor 151 is exposed to from the electromagnetic radiation that output end 112 flows out.Such exposure can It can lead to 151 absorption of electromagnetic radiation of temperature sensor, lead to the measured temperature of damage or mistake.In order to avoid such case, Temperature sensor 151 is arranged, positions or is located on longitudinal portion 114, and longitudinal portion 114 itself is flowed out from output end 112 Electromagnetic wave propagation path removes, deviates or shifts.

In some examples, except the range of the arrangement of temperature sensor 151, positioning or the Occupational exposure to magnetic fields positioned at output end 112. For example, temperature sensor 151 can be disposed in except the minimum range apart from output end 112.In some instances, depending on setting Standby 100 operating condition, the position of temperature sensor 151 can change, to prevent from being directly exposed to radiating.

However, in order to improve the accuracy of measured temperature, it may be preferred to ground make temperature sensor 151 be located at lean on as far as possible The position of the tissue closely just radiated by equipment 100.Therefore, in some instances, temperature sensor 151 should be as close to output It holds 112 and is not exposed to the electromagnetic radiation flowed out from output end 112.In the example embodiment illustrated by Fig. 1 and 2, temperature is passed Sensor 151 is arranged, positions or positioned at the end close to output end 112 or the longitudinal portion 114 near output end 112.

In other examples, equipment 100 further comprises for protecting temperature sensor 151 to be not exposed to by output end The electromagnetic shielding of 112 outputs and/or the electromagnetic wave from the reflection of diffusing globe 130 or scattering.By this method, by by temperature sensor 151 direct absorption of electromagnetic energy, measured temperature is unaffected or impacted minimum.

With reference to Fig. 5, another example apparatus 200 for interstitial laser therapy is instantiated.Equipment 200 includes vertical around center Extend and have the optical waveguide 210 of optics output end 212 to axis 220.Equipment 200 further comprises optical diffuser 230, should Optical diffuser 230 is optically coupled to output end 212 or optically associated with output end 212 or be located in output end Around 212.Diffusing globe 230 includes shell 232, which has for accommodating output end 212 and optical waveguide 210 The open end 234 of one longitudinal portion 214.Equipment 200 further comprises the first temperature sensor 251 and second temperature sensor 252, the first temperature sensor 251 is inserted into, positions or between longitudinal axis 220 and the outer surface 236 of shell 232, and In the longitudinal extent of the first longitudinal direction part 214 of optical waveguide 210, and second temperature sensor 252 is attached or is fixed to light Learn waveguide 210.As previously mentioned, in another example, the first temperature sensor 251 can be located at the outer surface of optical diffuser 230 236 inside.

Preferably, but not necessarily, second temperature sensor 252 is arranged, positions or is located in optical waveguide 210 simultaneously And it is located at the outside of optical diffuser 230.Second temperature sensor 252 is attached or to be fixed on the second of optical waveguide 210 vertical Into part 216.Second temperature sensor 252 is arranged, positions or near the open end of optical diffuser 230 234.The Two temperature sensors 252 are from 251 vertical misalignment of the first temperature sensor or shift.In some instances, the first temperature sensor 251 and 252 vertical misalignment of second temperature sensor about 5mm.In some instances, the first temperature sensor 251 and second temperature 252 vertical misalignment of sensor about 4mm to about 6mm or about 3mm to about 7mm or about 2mm to about 8mm.In other examples, first The vertical misalignment of random length can be used between second temperature sensor 251 and 252.

In addition, although the first temperature sensor 251 and second temperature sensor 252 are illustrated as being located at optical waveguide 210 Circumferentially opposed end, but it's not necessary.In other examples, the first temperature sensor 251 and second temperature can be used to pass It is any relatively circumferentially displaced between sensor 252.Center longitudinal axis 120 not with the first temperature sensor 251 and/or second temperature Sensor 252 intersects or passes through.First temperature sensor 251 and/or second temperature sensor 252 are positioned to and optics output end 112 separate.First temperature sensor 251 can be positioned near the inner surface of optical diffuser 230 and/or adjacent optical diffuser The inner surface of device 130.Second temperature sensor 252 can be positioned in except the longitudinal extent of optical diffuser 230, i.e., second In longitudinal portion 216.

Optical waveguide 210 includes internal layer 242 and the outer layer 244 radially around internal layer 242.Second longitudinal direction part 216 is light Longitudinal portion, section or the segmentation for learning waveguide 210, in the outside of shell 232.Preferably, but not necessarily, second longitudinal direction 216 close proximity 232 of part is abutted directly against with shell 232.Second longitudinal direction part 216 can have any longitudinal length, such as 1mm, 2mm, 3mm, 4mm, 5mm or any other length.Preferably, second longitudinal direction part 216 not with 214 weight of first longitudinal direction part It is folded or not coextensive with first longitudinal direction part 214.

Peel off outer layer 244 at least partly to accommodate second temperature sensor 252 in second longitudinal direction part 216.It is recessed, is recessed Slot or recess are formed in outer layer 244, and second temperature sensor 252 is arranged, is located or positioned in this recess.In In other examples, second temperature sensor 252 is embedded into the outer layer 244 of second longitudinal direction part 216.

Recess for accommodating second temperature sensor 252 can be by the outer layer 244 in etching second longitudinal direction part 216 Part or slice are to form.The depth of recess makes the outer layer 244 in second temperature sensor 252 and second longitudinal direction part 216 Remaining ribbon contacts or attachment.In other examples illustrated in Fig. 6, the depth of recess makes second temperature sensor 252 The expose portion of internal layer 242 is contacted or is attached to the expose portion of internal layer 242.As illustrated in Figure 6, the first temperature sensor 251 can also contact or be attached to the expose portion of internal layer 242 with the expose portion of internal layer 242.That is, for accommodating first Recess with second temperature sensor 251 and 252 can be complete by the segmentation along the first and second longitudinal portions 214 and 216 It etches or peels off outer layer 244 and formed.

In some instances, the depth capacity of recess is about 0.3mm depth.In some instances, the depth capacity of recess is small In about 1mm.In other examples, recess can have any other maximum depth value.In other examples, second temperature senses Device 252 is arranged, is located or positioned in the covering of internal layer 242, without hindering biography of the electromagnetic wave in the sandwich layer of internal layer 242 It broadcasts.

In some instances, 252 useful binders of second temperature sensor are attached to optical waveguide 210, such as based on cyanogen The adhesive of base acrylate.In other examples, it can be used and second temperature sensor 252 firmly fixed or be attached to light Learn any other mechanism of waveguide 210.

Preferably, but not necessarily, the depth of recess makes second temperature sensor 252 not protrude or protrude past The outer diameter of optical waveguide 210.

Preferably, but not necessarily, second temperature sensor 252 is microtemperature sensor, or is had and optical waveguide The temperature sensor for the size (such as millimeter or submillimeter) that 210 characteristic lateral section size is consistent.In some instances, second Temperature sensor 252 is integrated temperature sensor, including the integrated circuit for measuring temperature.

In some instances, second temperature sensor 252 is thermoelectricity occasionally low-grade fever galvanic couple.In other examples, temperature passes Sensor 252 is infrared temperature sensor.In other examples, second temperature sensor 252 need not can directly contact In the case of measure object temperature fully-integrated MEMS (MEM) thermopile sensor, such as Texas Instrument TMP006 or TMP006B infrared thermopile non-contact temperature sensor.In other examples, other kinds of temperature can be used Sensor, such as digital temperature sensor, analog temperature sensor, electronic temperature transmitter, mechanical temperature sensor, temperature-sensitive electricity The temperature sensor of resistance, silicon band gap temperature sensor or any other type.

In other examples, second temperature sensor 252 is radio temperature sensor, transmits it by means of Radio Link Measured temperature.In some examples, second temperature sensor 252 is the radio temperature sensor wirelessly powered, such as previously Description.

In addition, in some instances, second temperature sensor 252 and the type having the same of the first temperature sensor 251 Or type.For example, both the first temperature sensor 251 and second temperature sensor 252 can be low-grade fever galvanic couple.Show at other In example, compared with the first temperature sensor 251, second temperature sensor 252 has different type or type.For example, first Temperature sensor 251 can be infrared temperature sensor, and second temperature sensor 252 can be low-grade fever galvanic couple.Show at other In example, the first temperature sensor 251 and second temperature sensor 252 can have identical or different operating characteristic (for example, temperature Measurement range, Measurement Resolution) and rated value.

During the operation of equipment 200, the first temperature sensor 251 and the measurement of second temperature sensor 252 or sensing are not Same temperature.The first temperature sensor 251 is provided to measure the temperature of the tissue radiated for interstitial laser therapy, and is mentioned The temperature of other objects and/or tissue is measured for second temperature sensor 252.Since second temperature sensor 252 is from diffusion Device 230 deviates, therefore it is not adapted to the temperature for the tissue that measurement is just being radiated.In some instances, second temperature senses Device 252 is adapted to the temperature outside measurement optical diffuser 230.In some instances, second temperature sensor 252 provides ginseng It examines or datum temperature is read.For example, second temperature sensor 252 can measure with just treated tissue adjoining, just treated Tissue around or neighbouring tissue temperature.Then can consider relative to the measured temperature of second temperature sensor 252 The measured temperature of first temperature sensor 251.For example, equipment 200 can provide the first temperature sensor 251 and second temperature passes The measurement of temperature gradient or difference between sensor 252.In some instances, the first temperature sensor 251 and second temperature sensing Device 252 is adapted to measurement temperature difference.

In other examples, second temperature sensor 252 can be used for monitoring should not be heated during interstitial heat therapy Tissue temperature.For example, second temperature sensor 252 allows the operator to monitor healthy group around tumour being treated The temperature knitted, and adjustment appropriate is carried out in the case where the temperature of health tissues is more than some level of security.Alternatively, Two temperature sensors 252 provide spare, redundancy or replacement temperature sensor, to prevent the first temperature sensor 251 in therapeutic process In become unavailable or faulty.

In other examples, equipment 200 may include additional temperature sensor, such as three, four or more temperature Sensor.

With reference to Fig. 7, another example apparatus 300 for interstitial laser therapy is instantiated.Equipment 300 includes vertical around center Extend and have the optical waveguide 310 of optics output end 312 to axis 320.Equipment 300 further comprises optical diffuser 330, should Optical diffuser 330 is optically coupled to output end 312 or optically associated with output end 312 or be located in output end Around 312.Diffusing globe 330 includes shell 332, which has for accommodating output end 312 and optical waveguide 310 The open end 334 of one longitudinal portion 314.Shell 332 has outer surface 336.Equipment 300 further comprises the first temperature sensor 351 and second temperature sensor 352, the first temperature sensor 351 is inserted into, positions or is located at center longitudinal axis 320 and appearance Between face 336, and in the longitudinal extent of the first longitudinal direction part 314 of optical waveguide 310, and 352 quilt of second temperature sensor Fixed to optical waveguide 310.As previously mentioned, in another example, the first temperature sensor 351 can be located at optical diffuser 330 Outer surface 336 inside.

Optical waveguide 310 includes internal layer 342 and the outer layer 344 radially around internal layer 342.First temperature sensor, 351 quilt Outer layer 344 fixed to first longitudinal direction part 314.Second temperature sensor 352 is fixed on the second longitudinal direction of optical waveguide 310 In part 316.Second temperature sensor 352 is fixed to the outer layer 344 of second longitudinal direction part 316.First and second longitudinal directions portion 314 and 316 are divided not to be stripped or scrape off outer layer 344.This construction can be convenient for the manufacture or assembling of equipment 300.

Shell 332 should be provided with internal diameter, which is more than the outer diameter of optical waveguide 310, to accommodate the first temperature sensing Device 351.

With reference to Fig. 8, the rough schematic view of equipment 300 is instantiated, it illustrates various substitution points or positions, wherein can be independent Or the first temperature sensor and second temperature sensor or additional temperature sensor are arranged, position, are embedded in or are arranged in combination.

In one example, the first temperature sensor 370 is embedded into the outer layer 344 of first longitudinal direction part 314, and portion Divide ground towards the exposure of output end 312, or is exposed near output end 312.In another example, the first temperature sensor can quilt It is completely embedded into outer layer 344.In another example, the first temperature sensor 372 is positioned in the outer layer of first longitudinal direction part 314 On 344, and protrudes or protrude towards output end 312.In another example, the first temperature sensor 374 is positioned in first On the outer layer 344 of longitudinal portion 314, and shifted from the end of the first longitudinal direction part 314 near output end 312.For example, First temperature sensor 364 can be positioned near open end 334.In another example, the first temperature sensor 376 is positioned In the groove of shell 332, recess or intracavitary.In other examples, outer layer 344 and shell 332 can both be both provided with for holding Receive corresponding groove, recess or the chamber of the first temperature sensor 376.In other examples, the first temperature sensor can be embedded into, In the covering of positioning, arrangement or the internal layer 342 in first longitudinal direction part 314, and it is arranged to and electromagnetic wave is not hindered to exist Propagation in the sandwich layer of internal layer 342.

In one example, second temperature sensor 378 is embedded into the outer layer 344 of second longitudinal direction part 316.At other In example, second temperature sensor 378 can be only partially embedded into the outer layer 344 of second longitudinal direction part 316.In another example In, second temperature sensor 380 is positioned on the outer layer 344 of second longitudinal direction part 316, and from shell 332 and open end 334 offsets, displacement remove.In various embodiments, the distance between second temperature sensor 380 and open end 334 can be with Variation.In other examples, second temperature sensor can be embedded into, position, arranging or in second longitudinal direction part 316 in In the covering of layer 342, and it is arranged to the propagation for not hindering electromagnetic wave in the sandwich layer of internal layer 342.

In various further examples, it can be used in any first temperature sensor 351,370,372,374 and 376 Two or more.In another example, two or more in any second temperature sensor 352,378 and 380 can be used It is a.

System for interstitial laser therapy

With reference to Fig. 9, the example system 400 for interstitial laser therapy is instantiated.System 400 includes controlling for interstitial laser The equipment 410 for the treatment of, as described in any aforementioned exemplary.System 400 further comprises the optics wave for being optically coupled to equipment 410 The power adjustable light source 420 and processing system 430 for the input terminal led.Processing system 430 is configured to one from equipment 410 A or multiple temperature sensors obtain one or more measured temperatures, and adjust the Optical output power of light source 420.

Optical signalling is delivered to optical waveguide and allows that the power of optical signalling is tuned or is adjusted by light source 420. In some instances, light source 420 is laser or LED, or can generate the other equipment of optical signalling.In other examples, Light source 420 is the humorous active equipment of power adjustable for the optical waveguide that optical signalling (generating from another light source) is relayed to equipment 410 (such as amplifier) or the humorous inactive component of power adjustable (such as attenuator or tunable coupler).

In some instances, processing system 430 is directly received or is obtained from one or more temperature sensors of equipment 410 One or more measured temperatures.In other examples, processing system 430 is from being connected to the one of one or more temperature sensors A or multiple peripheral equipments receive or obtain one or more measured temperatures, and peripheral devices are based on from one or more temperature The sensing data that degree sensor obtains calculates the temperature for the one or more tissues being treated.Example peripheral device includes Voltmeter, power meter, spectrometer or for explaining sensing data and being converted into any other instrument of measured temperature. In another example, processing system 430 calculates just quilt based on the sensing data obtained from one or more temperature sensors The temperature of the tissue for the treatment of.

Processing system 430 determines how the Output optical power of adjustment light source 420 dependent on measured temperature.Show some In example, processing system 430 can be dependent on additional information or data to determine how the Output optical power of adjustment light source 420.This is attached Adding information may include the type of the size of just treated tumour and the tissue of size and tumour.It can be before start of the treatment This information is determined using medical imaging devices.In some instances, processing system 430 is determining how the defeated of adjustment light source 420 When light power, it can rely on the optical wavelength including optical power/energy requirement, exposed/radiated time and specific organization or tumour and want The tables of data asked.

System 400 can further comprise the channel for equipment 410 to be delivered to treatment region.The example in channel includes leading Pipe, intubation, tube body or any other channel, this depends on the position of the tumour or tissue that are being treated (for example, liver, pancreas Gland, prostate, brain or patient's body any other position).Channel can be inserted into patient's body.Equipment 410 will be inserted into logical In road, the diffusing globe of equipment 410 is as leading part, and the optical waveguide of equipment 410 is then fed by channel.Therefore, Channel guides equipment 410 to treatment region.

In another example, channel (be intubated) can be equipped with transparent end and/or closed trocar tip (or other The tip instrument of type).Intubation with transparent ends allows laser energy and/or heat to be transmitted in tissue from intubation.It passes The trochar of system be it is solid, be usually made of opaque plastics or metal.Traditional trochar is also without closed end.

In one example, using having cuspidated trochar, can be used for penetrating tissue as normal intubation.Point It holds cleavable and penetrates tissue and/or skin.The end in channel (be intubated) preferably by transparent material, optically transparent material or Optical translucent material is made.Optionally, the whole length of intubation can be by identical material (transparent material, optically transparent material Or optical translucent material) be made.That is, at least in some instances, at least end of channel (being intubated) is transparent Or it is translucent.These examples allow laser energy and/or heat to penetrate cannula wall and enter surrounding tissue.In another optional form In, if be used together with rinse fluid art, intubation can also be equipped with flushing outlet and rinse inlet.

System 400 can further comprise setting for the imaging of the positioning device 410 when equipment 410 is delivered to treatment region It is standby.Exemplary imaging device includes MRI scanner, ultrasound scanner or other echolocation scanners.One of equipment 410 is excellent Point is that it can measure the temperature for the tissue being treated without additional diagnostic device.This allows using such as usually not It is capable of measuring the simpler imaging device of ultrasound scanner of temperature etc, in order to positioning device 410 during treatment.

Advantageously, system 400 provides feedback mechanism, can accurately monitor the temperature of the tumour or tissue that are being treated Level, and the Output optical power of tumour or tissue is delivered to by means of adjustment to adjust this temperature levels.Due to used member The complexity of part reduces, this feedback procedure can execute in real time (or with low latency).That is, it is no longer necessary to multiple using height Miscellaneous MRI scanner only estimates temperature.

Processing system

With reference to Figure 10, exemplary processing system 430 is instantiated.Specifically, processing system 430 generally comprises at least one Manage device 502 or processing unit or multiple processors, memory 504, at least one input equipment 506 and at least one output Equipment 508, they are coupled via bus or one group of bus 510.In certain embodiments, input equipment 506 and output Equipment 508 can be same equipment.The interface for processing system 430 to be coupled to one or more peripheral equipments can also be provided 512, such as interface 512 can be pci card or PC card.Accommodate at least one storage equipment 514 of at least one database 516 It can be provided that.Memory 504 may be any type of memory devices, for example, volatibility or nonvolatile memory, solid-state Store equipment, magnetic apparatus etc..Processor 502 may include more than one different processing equipment, such as in processing system The different function of processing in system 430.

The reception of input equipment 506 input data 518 (such as temperature reading or the number from one or more temperature sensors According to), and may include the pointing device of such as keyboard, such as pen-like devices or mouse etc, such as microphone etc for language The data sink or day of audio reception device, such as modem or the wireless data adapter of the activation of sound control system etc Line, data collecting card etc..Input data 518 may be from different sources, for example, keyboard instruction with via the received data of network.It is defeated Equipment 508 generates or generates output data 520 and may include out, for example, display equipment or monitor (export in the case Data 520 are visual), printer (output data 520 is printed in the case), port (such as USB port), peripheral group Part adapter, data source or antenna (such as modem or wireless network adapter) are sent to control or adjust The data etc. of the Output optical power of whole light source 420.Output data 520 can be different and lead from different output equipments Out, the visual display such as on monitor combines the data for being transmitted to network.User can be on such as monitor or use is beaten Print machine come check data output or data output explanation.Storage equipment 514 may be any type of data or information storage Device, such as volatibility or nonvolatile memory, solid storage device, magnetic machine, etc..

In use, processing system 430 is adapted to that data or information is allowed to be deposited via wired or wireless communication means Storage is retrieved at least one database 516 and/or therefrom.Interface 512 can permit processing unit 502 and can serve spy Wired and or wireless communications between the peripheral components of different purpose.Processor 502 receives instruction conduct via input equipment 506 Input data 518 and can by using output equipment 508 to user show processed result or other export.One can be provided A above input equipment 506 and/or output equipment 508.It should be understood that processing system 430 may be any type of terminal, clothes Business device, special hardware, etc..

Further example

Following example provides being discussed more fully for each specific embodiment.For the scope of the present invention, each example is intended to It is only illustrative and not restrictive.

In previously discussed any example, a part of diffusing globe or diffusing globe be optionally additionally provided with one or Multiple holes, one or more slits, one or more openings, and/or one or more ventholes.For example, one or more holes, Slit, opening and/or venthole can be used to diffuse electromagnetic energy (such as laser energy) preferably from laser fiber It goes out.This, which advantageously causes to reduce, damages diffusing globe tip and preferably penetrates into energy in tissue.

Traditionally, laser optics diffusing globe tip is solid and transparent or semitransparent, so that laser energy can diffuse out It goes.This will lead to diffusing globe fever.Due to the effect of laser energy, diffusing globe can overheat and disintegrate.Laser energy is delivered to Tissue may also tend to burn and burn, rather than be gradually warmed up and energy allowed to penetrate into tissue.

In further example, one or more holes, one or more slits in diffusing globe, one or more are opened Mouth, and/or one or more ventholes additionally allow to organize the gas of generation from the inner area of diffusing globe from what is be just heated Domain evolution, diffusion or discharge, and it is transmitted to energy more stably in tissue again.That is, in use, generation Gas is via one or more holes, one or more slit, one or more openings, and/or one or more ventholes from light Learn the interior zone evolution of diffusing globe.

The particularly advantageous purposes of " open ", " non-solid " or " semiclosed " diffusing globe is, if with rinse solution one It rises using to cool down diffusing globe, then rinse solution has more preferably and be easier the approach into diffusing globe.This allows diffusing globe quilt It more effectively cools and allows for using higher laser power, without being damaged to diffusing globe or tissue being caused to burn and fire It burns.Additionally, this can also allow from the heating to tissue or the gas discharged from rinse solution simultaneously more easily from diffusing globe Interior zone evolution, diffusion or discharge.

One or more hole, one or more slits, one or more openings, and/or one or more ventilations can be used Various types, shape, quantity, orientation and/or the construction in hole.

With reference to Figure 11, example optical diffusing globe is shown, preferably (or the tubular optical of cylindric optical diffuser 630 Diffusing globe).Relative length, thickness and the diameter of optical diffuser 630 are provided by way of example only, and one or more holes 640 take It is also such to, location and range.One or more holes 640, i.e., one or more openings and/or one or more ventholes, It is set along at least part of the longitudinal length of optical diffuser 630 and in different circumferential locations, and passes through optics The shell of diffusing globe 630 is to extend to inner surface from the outer surface of optical diffuser 630.

With reference to Figure 12, instantiate another example optical diffusing globe 730, be equipped with one or more slits 740, i.e., one or Multiple openings 740 and/or one or more ventholes 740.One or more slits 740, i.e., one or more openings and/or one A or multiple ventholes, along at least part of the longitudinal length of optical diffuser 730 and in different circumferential location quilts Setting, and the shell of optical diffuser 730 is passed through to extend to inner surface from the outer surface of optical diffuser 730.More than one Slit can be set along the longitudinal length of optical diffuser 730.

It should be appreciated that can provide along any length of example diffusing globe, part, range or circumference by means of Figure 11 and 12 Example illustrated by one or more hole, one or more slit, one or more openings and/or one or more ventilations Hole.It can provide various types of hole, slit, opening and/or venthole.Similarly, it is possible to provide various holes of different shapes, Slit, opening and/or venthole.Additionally, it is possible to provide any amount of hole, slit, opening and/or venthole are as diffusing globe A part.Additionally, it is possible to provide a part of hole, slit, opening and/or the venthole of various orientations as diffusing globe.It is attached Add ground, it is possible to provide hole, slit, opening and/or venthole mixture a part as diffusing globe of various constructions.

As illustrated by the example by means of Figure 11 and 12, one or more holes, one or more slits, one or more Opening and/or one or more venthole can surround the circumferential registration of diffusing globe, and can along diffusing globe longitudinal extent or At least part of length positions.Any required amount of hole, slit, opening and/or venthole can be with any desired angles Degree interval surrounds circumferential registration.It as non-limiting example, only provides in the way indicated, hole, slit, opening and/or ventilation Hole can have the length or diameter of about 0.1mm to about 10mm.Hole, slit, opening and/or venthole can be spaced apart for example, about 0.5mm to about 10mm.Assuming that needing four lines or pattern longitudinally extended, the then longitudinal direction of hole, slit, opening and/or venthole Extension line or pattern can be circumferentially spaced about 90 degree.Assuming that need three lines or pattern longitudinally extended, then hole, slit, open The longitudinally extending line or pattern of mouth and/or venthole can be circumferentially spaced about 120 degree.Assuming that needing two lines longitudinally extended Or pattern, then the longitudinally extending line of hole, slit, opening and/or venthole or pattern can be circumferentially spaced about 180 degree.Another In one example, it is assumed that need a line or pattern longitudinally extended, then one for providing hole, slit, opening and/or venthole is vertical To extension line or pattern.

With reference to Figure 13, the side view of another example optical diffusing globe 830,930,1030,1130,1230,1330 is instantiated, Its hole with different exemplary types, shape, orientation and/or construction, slit, opening and/or venthole.Example optical diffusing globe It is illustrated as that there is uncertain longitudinal extent.Example optical diffusing globe is three-dimensional tubulose or cylindric.Diffusing globe 830 includes One or more longitudinally-aligned slits or venthole 840.Diffusing globe 930 includes one or more angled slits or ventilation Hole 940.Diffusing globe 1030 includes one or more holes or venthole 1040.Diffusing globe 1130 includes one or more holes or opening With the combination of one or more slits 840.Hole of different shapes, opening, construction, orientation and/or the arrangement of venthole or slit It can significant changes.Diffusing globe 1230 includes one or more slits 1240 of vertical alignment.Diffusing globe 1330 includes at least partly Ground along the longitudinal extent or length of diffusing globe 1330 with it is different or periodically one of circumference (or radial) angle offset or Multiple holes or opening 1340.It should be appreciated that hole shown in example diffusing globe, slit, opening and/or venthole quantity only For illustrating, and a hole of any quantity (such as one, two, three, four, five, six, seven, eight, nine, ten etc.) can be used, slit, open Mouth and/or venthole or any combination thereof.

Figure 14 instantiates a part of example system or assembly 1400 for interstitial laser therapy.System or assembly 1400 include optical diffuser (and other assemblies) assembly part 1410, for the connector 1420 of laser fiber, for the The connector 1430 of one thermocouple (i.e. the first temperature sensor) and for the second thermocouple (i.e. second temperature sensor) Connector 1440.

Figure 15 instantiates the further details of optical diffuser (and other assemblies) assembly part 1410.Optical diffuser 1530 are attached to the laser fiber 1540 (with sheath).It can provide the first thermocouple 1510 (i.e. the first temperature sensor) and can Second thermocouple 1520 (i.e. second temperature sensor) of choosing.Also illustrate laser fiber 1550, it is therefore preferred to have transparent two Silica tip.Optical diffuser 1530 can be glued or otherwise be attached (for example, frictionally installing) to laser fiber On 1540.One or more holes, opening and/or venthole 1560 are provided as a part of optical diffuser 1530.

Figure 16 instantiates another example system or assembly 1600 for interstitial laser therapy.Can be used various types or The connector 1610 of configuration be used to connect the tube body or pipeline of conveying cooling fluid.Cooling fluid can be by input channel or tube body 1620 are introduced by connector 1610, to be directed into (that is, around optical diffuser part) operable area 1630.It can grasp Making region 1630 includes optical diffuser 1530, the first thermocouple 1510 (i.e. the first temperature sensor), the second thermocouple 1520 (i.e. second temperature sensor), (with sheath) laser fiber 1540 are as at least partly component.Laser fiber 1540 and heat Galvanic couple (i.e. temperature sensor) can be inserted into sheath tube body by least some of connector 1610 or connector 1610.

Figure 17 instantiates another example system or assembly 1700 for interstitial laser therapy.Connector 1715 includes using Cooling fluid is introduced in via first entrance/outlet body or pipeline 1750 and second entrance/outlet body or pipeline 1755 Or it is transported to the connector arrangement of operable area 1735.In (i.e. around optical diffuser part) operating area 1735, Optical diffuser 1730, the first thermocouple 1710 (i.e. the first temperature sensor), 1720 (i.e. second temperature of the second thermocouple are provided Sensor), (with sheath) laser fiber 1740 and sheath tube body 1770.Additionally provide 1780 (In of guiding device first part It is optical clear or transparent tube body in this example) and guiding device second part 1790 (being metal tube in this example). The sharp instrument of trochar 1795 or other forms is equipped in end.

In other examples, guiding device (i.e. channel or intubation) can be equipped with optically transparent end and/or closed casing Needle tip.Guiding device or channel or intubation with transparent ends allow laser energy and/or heat to pass from guiding device or intubation It sends out and enters in tissue.Trochar has the tip that can be used for that tissue is penetrated as normal intubation.In an example In, the intubation with the trocar tip for being set as clear tip or translucent tip can be used.Guiding device or channel or intubation End can be made of transparent material, optically transparent material or optical translucent material.Optionally, guiding device or channel or intubation Whole length can be made of identical material (i.e. transparent material, optically transparent material or optical translucent material).These show Example allows laser energy and/or heat penetrates guiding device or channel or the wall of intubation enters surrounding tissue.As shown, if with Cooling or rinse fluid art is used together, then guiding device or intubation may be provided with fluid or rinse inlet/outlet.In other examples In, guiding device or channel or intubation can be opaque, such as be made of metal or ceramics.

Guiding device (i.e. channel or intubation) or its end and trochar (i.e. puncture spine part or region or metal spine) Can be it is transparent, optically transparent or optical translucent, and together can be used as combination or integrated trochar-diffusion Device equipment or unit.That is, trochar can work similarly and/or complementary with optical diffuser with optical diffuser It works on ground.Trochar (i.e. puncture spine part or region or metal spine) can also be used as while being used as trochar Optical diffuser (or a part of optical diffuser).That is, trochar has dual function.In such example, set Pipe needle is optically coupled to the optics output end or optically associated with the optics output end of optical waveguide of optical waveguide, similar In previously for described in optical diffuser.Trochar can also be equipped with the entrance for rinse fluid art.

Figure 18 instantiates another example system or assembly 1800 for interstitial laser therapy.Connector 1815 (such as Including T-connection) it may include public Luer slip port 1825 and female Luer lock 1835, female Luer lock 1835 is connected to public Rule Cap 1845 and including fluid extension line or pipeline.System or assembly 1800 include trochar part 1895 or puncture sharp portion Point comprising metal spine 1890 or other cut edges can be glued or be otherwise attach to optical clear or saturating Bright tube body 1880.Optical clear or transparent tube body 1880 provide suitable optical clear or transparent form or region in order to just True laser operations.Connector 1815 is connected to optical clear or transparent pipe by tube body 1860 (it for example can be metal) Body 1880.

In another example, any metal tube 1860 may be not present, then optical clear or transparent tube body 1880 can In connector 1815 and trochar part 1895, or pierces through between sharp portion divides and extend.Fluid transmits extension line or pipeline 1870 are connected to female Luer lock 1875, and female Luer lock 1875 provides the outlet for being used for cooling fluid.System or assembly 1800 Including " guiding device " (being intubated) comprising the one or more with trocar tip (i.e. spine) hollow tube body or pipe Road.Hollow tube or pipeline are closed in distal end.It, can be by reinforcing rod such as during establishing the initial stage by the entrance of tissue (i.e. " reinforcer ") is placed through the centre of guiding device or intubation.Can provide sheath tube body, be reinforce tube body or pipeline, and And its assembly for accommodating laser fiber, one or more thermocouples (i.e. one or more temperature sensors) and optical diffuser Device, to allow these components to be inserted into guiding device.

Figure 19 shows the distal portions (i.e. puncture spine part or region) for trochar part 1900, has metal The cutting and/or penetration edges of spine 1910 or other forms.Also illustrate reinforcer 1920.In different examples, reinforce The end of part 1920 is accessible or the inner end (as shown in the figure) of contiguous metal spine 1910 or the end of reinforcer 1920 can be with The inner end of metal spine 1910 is spaced apart.

Figure 20 instantiates example connector 2000 and reinforcer 1920.Reinforcer 1920 (such as reinforcing rod), which can be inserted into, to be drawn It leads in device (being intubated).Public Rule cap 2010 from reinforcer 1920 is locked in female Luer and locks.In one example, it guides Device may include the opaque tube body (such as metal tube) and optical clear tube body that part longitudinally extends along its length, or guide The transparent tube body or optical clear forms that the proximate distal ends of device provide or longitudinally extend.In another example, guiding device can be One Duan Guanti is fully transparent, optically transparent or translucent material.

Optional embodiment may be additionally referred to as extensively include it is herein cited or instruction each section, element, step and/or Feature (independently or with the two or more any or all of combination of these parts, element step and/or feature), and It is wherein referred to herein in field according to the present invention with the specific integer of known equivalents, such known equivalents Object is to be considered as included in this paper (as by individually illustrating).

Although preferred embodiment has already been described in detail, it is to be understood that, without departing substantially from the scope of the present invention, perhaps More modifications, change, replacement or change will be apparent to those skilled in the art.