阅读说明：本技术 动脉瘤装置及递送系统 (Aneurysm devices and delivery system ) 是由 L.戈罗乔 A.索托德瓦勒 J.洛伦佐 于 2019-05-24 设计创作，主要内容包括：本公开题为“动脉瘤装置及递送系统”。本公开涉及一种用于治疗动脉瘤的编织物。所述编织物包括近侧可扩张部分,所述近侧可扩张部分定位于所述动脉瘤内,并且密封穿过所述动脉瘤的颈部。所述编织物还可包括远侧可扩张部分,所述远侧可扩张部分远离所述近侧可扩张部分,所述远侧可扩张部分用于填充所述动脉瘤。(The disclosure is entitled " aneurysm devices and delivery system ".This disclosure relates to a kind of for treating aneurysmal braided fabric.The braided fabric includes proximal expandable part, and the proximal expandable part is positioned in the aneurysm, and aneurysmal neck described in hermetically passing.The braided fabric may also include distal expandable part, and the distal expandable is partially away from the proximal expandable part, and the distal expandable part is for filling the aneurysm.)

1. one kind is for blocking aneurysmal braided fabric, the braided fabric includes:

Proximal expandable part, the proximal expandable part is positioned in the aneurysm, and artery described in hermetically passing The neck of tumor；With

Distal expandable part, the distal expandable is partially away from the proximal expandable part, the distal expandable portion Divide filling the aneurysm, and outside power is provided in the portions of proximal, maintains it in the aneurysm Appropriate location.

2. braided fabric according to claim 1, wherein in the deployed state, the proximal expandable part, which is formed, surrounds institute The annular expansion section of the aneurysmal neck seal is stated, and distal expandable part formation filling is described aneurysmal Distal side capsule.

3. braided fabric according to claim 2, wherein the annular expansion section forms around the lower end of the distal side capsule, falls Turn and surround the lower end of the distal side capsule.

4. braided fabric according to claim 2, wherein the porosity of the proximal expandable part can less than the distal side The porosity of expansion.

5. braided fabric according to claim 4, wherein corresponding porosity by gap, braid angle, be heat-treated and cover The size of at least one of cover material limits.

6. braided fabric according to claim 2, wherein the annular expansion section is covered on the outside of the distal side capsule, thus When the braided fabric is expanded to the unfolded state, the outside of the distal side capsule can be pressed against the interior table of the annular expansion section Face.

7. braided fabric according to claim 6, wherein when the annular expansion section is reversed around the distal side capsule, in institute It states and forms gap or cavity between annular expansion section and the distal side capsule.

8. braided fabric according to claim 2 further includes that setting can expand in the proximal expandable part with the distal side Open the conical section between part.

9. braided fabric according to claim 8, wherein the porosity of the proximal expandable part is lower than the conical section With the porosity of the distal expandable part.

10. braided fabric according to claim 8 further includes buckle portion, the buckle portion is limited to the conical section Between the proximal expandable part or the distal expandable part.

11. a kind of treat aneurysmal system, the system comprises:

Microtubular；

Delivery tube, the delivery tube are arranged in translatablely in the microtubular；With

Braided fabric, according to claim 2, the braided fabric is detachably connected to the delivery tube to the braided fabric, and And be slidably disposed in the microtubular with collapsed state, and out of described microtubular to distal translation to expansion shape State；

Wherein when the distal end of the braided fabric leaves the microtubular, the braided fabric, including distal expandable At least one of part and proximal expandable part, are expanded to the unfolded state.

12. system according to claim 11, wherein when the braided fabric distad translates and institute from the microtubular When stating braided fabric and being pushed against on the aneurysm wall, the annular expansion section is covered on the outside of the distal side capsule.

13. one kind is for being delivered to aneurysmal method for locking device, comprising:

The proximal end of the braided fabric is attached to the distal end of delivery tube；

Braided fabric is located in microtubular；

Selectively the braided fabric is located in the vascular system together with the delivery tube；

Slide the braided fabric from the microtubular towards the aneurysm distal side by the delivery tube, to make described dynamic It expands to form distal side capsule distal expandable part inside arteries and veins tumor；And

Expansion segment is circularized around the occlusion scrotiform by reversing at the proximal end of the braided fabric；

Discharge the braided fabric.

14. according to the method for claim 13, further includes:

The braided fabric is located in microtubular；

The proximal end of the braided fabric is attached to the distal end of delivery tube；And

The aneurysm is filled by forming the distal side capsule.

15. according to the method for claim 13, further includes:

Lock part is attached to institute at the proximal end of the braided fabric and the distal end of the delivery tube State delivery tube；And

The delivery tube is discharged from the braided fabric by the lock part.

16. according to the method for claim 13, further includes:

The annular expansion section is expanded, so that the annular expansion section covers the outer surface of the distal side capsule.

17. according to the method for claim 16, further includes:

When the braided fabric distad moves in the aneurysm, by one of the outer surface of the distal side capsule or more A outer end is pressed against in the annular expansion section.

18. according to the method for claim 17, further includes:

When the annular expansion section is reversed around the outer surface of the occlusion capsule, in the annular expansion section and described remote At least one of gap or cavity are formed between the capsule of side.

19. according to the method for claim 13, further includes:

Make the porosity of the proximal expandable part be less than the proximal expandable part and the distal expandable part it Between at least one of conical section porosity；

The proximal expandable section is positioned to or connection adjacent with the aneurysmal neck；And

It deflects, turn to or slows down into the aneurysmal flowing.

20. a kind of aneurysmal method of occlusion, comprising:

The braided fabric is moved distally in the aneurysm；

The proximal expandable part of the braided fabric is expanded to expansion state from collapsed state, to seal described aneurysmal Neck；And

The distal expandable part of the braided fabric described in the aneurysm interior expansion, to form distal side capsule, thus described in filling Aneurysm.

Technical field

This disclosure relates to medical instrument, more particularly, to the delivery system for aneurysm treatment.

Background technique

Aneurysm may be complicated and difficult to treat.For example, treating access when aneurysm is located near critical tissue It may be restricted or unavailable.Due to the corresponding limited therapeutic access of brain tissue around cranium vascular, such factor especially with Cranium aneurysm is related.

Existing solution includes endovascular treatment access, and wherein the internal volume of aneurysmal sack is removed or excludes dynamic Except arteries and veins blood pressure and blood flow.In this respect, because aneurysmal inner wall may continue to by blood flow and relevant pressure, institute It is still possible with aneurysm rupture.

Intravascular or other surgical methods alternative solutions may include locking device.This device usually have be incorporated to it is more A embolic coil, these coils are delivered into vascular system using microcatheter delivery system.For example, when treatment intracranial aneurysm When, the delivery catheter with embolic coil is usually inserted by non-cranium blood vascular system by hip or the femoral artery of iliac region first System.Then, conduit is guided to the interested position to skull.Then, in aneurysmal capsule can filled with embolism materials with Thrombi is formed, the thrombus block protection arterial wall is not influenced by blood flow and related pressure.However, this locking device is certain There are certain disadvantages, including mass effect, this will lead to brain and its nerve is oppressed.

A kind of certain types of occlusive method by device is implanted into aneurysmal load tumor blood vessel be dedicated to delivering and Treat aneurysmal entrance or " neck " rather than aneurysmal volume.In this " neck " method, by making across neck Blood flow minimize, may be implemented enter aneurysmal flowing stopping.Then, thrombi can be with self-assembling formation, without passing Send embolism materials to aneurysmal sack, as previously described.This method is more more preferred than the block formed by embolism materials, because natural block can To improve healing by reducing the possible expansion of arterial wall, and allow to reintegrate original along aneurysmal neck plane Begin to carry in tumor shape of blood vessel.It should be appreciated that neck plane is an imaginary surface, wherein the innermost layer for carrying tumor wall will be artery Position where tumor.However, neck occlusive method, is such as implanted into choke apparatus in carrying tumor blood vessel, is not without disadvantage.It is such Method may hinder blood to flow into peripheral blood vessel, while block the aneurysm neck carried in tumor blood vessel.If the opening quilt of blood vessel Obstruction then prevents the flowing for flowing to peripheral blood vessel that from may causing unintentionally badly damaged.

The solution of the disclosure solves the problems, such as these and other of this field.

Summary of the invention

In some embodiments, this disclosure relates to for treating aneurysmal self expandable braided fabric.Braided fabric includes close Side expandable part, the proximal expandable part are positioned in aneurysm, and the aneurysmal neck of hermetically passing.Braided fabric is also Including distal expandable part, which is partially filled with dynamic partially away from proximal expandable part, the distal expandable Arteries and veins tumor, and outside power is provided in portions of proximal, maintain it in the appropriate location in aneurysm.

In some embodiments, braided fabric can be moved to the expansion in microtubular distal side from the collapsed state in microtubular State.

In some embodiments, in the deployed state, proximal expandable part, which is formed, surrounds aneurysmal neck seal Annular expansion section, and distal expandable part formed for filling aneurysmal distal side capsule.Annular expansion section can be by list A continuous part or multiple individual discrete portions (for example, the multiple expansions extended from the proximal end of braided fabric) shape At.

In some embodiments, the porosity of proximal expandable part is smaller than the porosity of distal expandable part. Corresponding porosity is limited by the size in gap, braid angle, heat treatment and covering.

In some embodiments, distal side capsule can be shaped as spherical shape, saddle type, ellipse or any other shape.Distal side Capsule is also possible to collapsible caged vascular occlusion structure.

In some embodiments, annular expansion section can form around the lower end of distal side capsule, reverse and surround distal side The lower end of capsule.In some embodiments, annular expansion section covering distal side capsule (for example, outside of covering distal side capsule).Distal side capsule Outer end or part can be orientated to be pressed against annular expansion section inner surface.When braided fabric is expanded to unfolded state, distal side capsule Outer end or part can be orientated to pressing proximal section.It, can be in annular expansion section and distal side when distal side bag pressure leans on ring segment Gap or cavity are formed between capsule, including the inner surface against annular expansion section.When annular expansion section is reversed around distal side capsule, Gap or cavity can also be formed between annular expansion section and distal side capsule.

In some embodiments, braided fabric further includes being arranged between proximal expandable part and distal expandable part Conical section.In this respect, proximal expandable part may include porosity lower than conical section and/or the hole of distal expandable part Gap rate.Proximal expandable part may include the increased braiding relative to conical section and/or the braid angle of distal expandable part Angle.Conical section may also include line segment more less than proximal expandable part and/or distal expandable part.In this respect, nearside Expandable part, distal expandable part and/or conical section can have different braided natures.

In some embodiments, buckle portion may include in braided fabric, which is limited to conical section and close Between side expandable part or distal expandable part.

In some embodiments, braided fabric has open distal end, and the proximal end of braided fabric is attached to Lock part that can be detachably connected with delivery tube.

In some embodiments, it discloses for treating aneurysmal system.The system includes microtubular, translatable The braided fabric of delivery tube in microtubular and the disclosure is set.Braided fabric can be detachably connected to delivery tube, and It is slidably disposed in microtubular with collapsed state, and to distal translation to unfolded state out of microtubular.Work as braided fabric Distal end when leaving microtubular, braided fabric (including distal expandable part and/or proximal expandable part) can be expanded To unfolded state.

In some embodiments, when braided fabric is distad translated from microtubular and braided fabric is pushed against aneurysm wall When upper, annular expansion section is covered on the outside of distal side capsule.

In some embodiments, which may include radiopaque entity, the platinum filament being such as woven into braided fabric Or the pipeline of the filling drawn with platinum, so that the device can be imaged under fluoroscopy.It will allow final use including these entities Family understands and visualization braided fabric is relative to aneurysmal position.The orientation and/or position of distal side capsule and/or annular expansion section can It is adjusted in microtubular distad or to nearside is mobile by braided fabric.

In some embodiments, which further includes being attached to the lock part of the proximal end of braided fabric.It is collapsing In state, lock part can be attached to the distal end of delivery tube.In the deployed state, lock part can be from delivery tube It removes, and braided fabric can remove in aneurysm.

In some embodiments, it also discloses a kind of for locking device to be delivered to aneurysmal method.This method Can include: the proximal end of braided fabric is attached to the distal end of delivery tube；Braided fabric is located in microtubular；Selectivity The braided fabric of delivery tube with attachment is located in vascular system (such as in aneurysmal neck) by ground；It will by delivery tube Braided fabric is distad slided from microtubular towards aneurysm, to make the distal expandable part inside aneurysm expand, with shape Expansion segment is circularized around distal side scrotiform at distal side capsule, and at the proximal end of braided fabric；Braided fabric is discharged, and driven Extract delivery tube and microtubular in arteries and veins tumor out.

In some embodiments, the aneurysm is filled by forming the distal side capsule.

In some embodiments, the selectivity positioning of braided fabric includes that the distal end of microtubular is placed on aneurysm Neck.

In some embodiments, distal expandable part is expanded simultaneously in the formation of annular expansion section.

In some embodiments, proximal section is expanded after distal segment expansion.

In some embodiments, this method further includes that lock part is attached to the proximal end and delivery tube of braided fabric Distal end；And pass through lock part release delivery pipe from braided fabric.

In some embodiments, this method further includes expanding annular expansion segment, so that annular expansion section covers distal side capsule Outer surface.

In some embodiments, this method further includes when braided fabric distad moves in aneurysm, by distal side capsule One or more outer ends be pressed against annular expansion section (for example, inner surface of annular expansion section).

In some embodiments, this method further includes when distal side bag pressure leans on the inner surface of annular expansion section, in annular Gap or cavity are formed between expansion segment and distal side capsule.

In some embodiments, this method further includes the In when annular expansion section is reversed around the outer surface of occlusion capsule Gap or cavity are formed between annular expansion section and distal side capsule.

In some embodiments, this method further includes being formed between proximal expandable part and distal expandable part Conical section.This method can also include that the porosity of proximal expandable part is made to be less than conical section and/or distal expandable part Porosity；Proximal expandable section is positioned to or connection adjacent with aneurysmal neck；And it deflects, turn to and/or slow down Into the aneurysmal flowing.This method can also include make proximal expandable part flexibility be less than conical section and/or The flexibility of distal expandable part；Proximal expandable section is positioned to or connection adjacent with aneurysmal neck；And deflection, It turns to and/or slows down into the aneurysmal flowing.In some embodiments, distal side capsule is had to flow through by providing blood Another braiding layer additional flowing transfer effect is provided.The ring segment and proximal end of distal side capsule can also provide increase Flowing transfer effect because blood has to flow through the extra play (for example, three layers) of the reticular structure including micropore.

In some embodiments, it discloses and a kind of treats aneurysmal method using braided fabric.This method may include by Braided fabric is located in aneurysm；Braided fabric is moved distally in aneurysm；By the proximal expandable part of braided fabric from Collapsed state is expanded to expansion state, to seal aneurysmal neck；And in the distal side of aneurysm interior expansion braided fabric Expandable part, to form distal side capsule, to fill aneurysm.

In some embodiments, the step of expanding the proximal expandable part of braided fabric may include in the close of braided fabric Expansion segment is circularized around distal side scrotiform at side end.

In some embodiments, this method may include around the outer surface of distal side capsule covering annular element；And when braiding When object is expanded to unfolded state, the outer end of distal side capsule is pressed against on the inner surface of ring segment, device is fixed on aneurysm On wall.

In some embodiments, this method may include when distal side bag pressure is by ring segment, in annular expansion section and distal side Gap or cavity are formed between capsule.

In some embodiments, this method may include being formed between proximal expandable part and distal expandable part Conical section.This method can also include that the porosity of proximal expandable part is made to be less than conical section and/or distal expandable part Porosity；And it deflects, turn to and/or slows down into the aneurysmal flowing.This method can also include making nearside can The flexibility of expansion is less than the flexibility of conical section and/or distal expandable part；And it deflects, turn to and/or slow down Into the aneurysmal flowing.

It checks in conjunction with attached drawing the following specifically describes later, other aspect and feature of disclosure skill common for this field Art personnel will become obvious.

Detailed description of the invention

With reference to the drawings, the drawings are not necessarily drawn to scale.

Fig. 1 shows the example locking device for the disclosure being deployed in aneurysm.

Fig. 2A is the schematic side elevation of the exemplary delivery system with the locking device collapsed in microtubular.

Fig. 2 B is the schematic side elevation of the exemplary delivery system with the locking device that distal side is disposed in microtubular.

Fig. 3 is the amplification schematic side elevation of the braided fabric shown in Fig. 1 to Fig. 2 in expansion state.

Fig. 4 is the amplification schematic side elevation of the another embodiment of braided fabric of the invention.

Fig. 5 A is that the amplification of the delivery system and braided fabric of Fig. 1 to Fig. 3 when braided fabric is pushed into example aneurysm is shown Meaning property side view.

Fig. 5 B is that the amplification of the delivery system and braided fabric of Fig. 1 to Fig. 3 when braided fabric is pushed into example aneurysm is shown Meaning property side view.

Fig. 6 A is that the amplification of the delivery system and braided fabric of Fig. 1 to Fig. 3 when braided fabric is pushed into example aneurysm is shown Meaning property side view.

Fig. 6 B is that the amplification of the delivery system and braided fabric of Fig. 1 to Fig. 3 when braided fabric is pushed into example aneurysm is shown Meaning property side view.

Fig. 7 A is the perspective diagram for showing the exemplary delivery system being used together with example locking device.

Fig. 7 B is the perspective diagram of Fig. 7 A, but the partial cross sectional with delivery system and locking device.

Fig. 8 A is the perspective diagram of Fig. 7 A to Fig. 7 B, is deployed with the partial cross sectional of delivery system and locking device.

Fig. 8 B is the perspective diagram of Fig. 7 A to Fig. 7 B, is deployed with the exemplary delivery system separated with locking device.

Fig. 9 is the flow chart for delivering the method for locking device.

Figure 10 is the flow chart for delivering the method for locking device.

Specific embodiment

Although the example embodiment of disclosed technology is explained in detail herein it should be appreciated that it is contemplated that other realities Apply scheme.Therefore, it is not intended that portion that the scope limitation of disclosed technology is illustrated in the following description or shown in the drawings The construction of part and the details of arrangement.Disclosed technology can have other embodiments and can practice in various ways or real It applies.

It is otherwise used in this specification and appended claims it is also to be noted that unless the context is clearly specified Singular " one/one " and " described/should " include plural object.So-called "comprising" or " containing " or " comprising " refer to Compound, element, particle or the method and step at least named are present in composition or product or method, but do not exclude the presence of it His compound, material, particle, method and step, even if other such compounds, material, particle, method and step have and name Those identical functions.

When describing example embodiment, for the sake of clarity, term will be used.It is intended to that each term is made to imagine its ability The broadest sense that field technique personnel understand, and all technologies etc. including operating in a similar manner to realize similar purpose Jljl.It is also understood that the one or more steps for mentioning method does not exclude the presence of additional method and step or clear at those Buffering technique step between the step of mark.In the case where not departing from the range of disclosed technology, can with it is described herein Order in a different order execute method the step of.Similarly, it is also understood that mention one or more of device or system Component does not exclude the presence of additional component or the intermediate member between the component that those are clearly identified.

As discussed herein, vascular system can be any " subject " or " patient " (including any human or animal) Vascular system.It should be appreciated that animal can be various any applicable types, including but not limited to mammal, veterinary animal, Livestock animals or pets animal etc..For example, animal, which can be, is specifically chosen the experiment with certain features similar with the mankind Animal (for example, rat, dog, pig, monkey etc.).It should be appreciated that subject can be for example any applicable human patients.

As discussed herein, " operator " may include doctor, surgeon or be delivered to subject with by knitted body Vascular system it is associated any other individual or delivering instrument.

Relatively, blood can be changed into aneurysmal flowing in the blood flow guiding device across aneurysm neck deployment.Example Property blood flow guiding device can be the braiding device with relatively low porosity.Over time, aneurysm can pass through Aneurysm neck is sealed with high success rate to cure.However, blood flow guiding technique is not without limitation.Challenge includes due to blood vessel shape State, buckling of vessel or braiding dislocation and apparatus for placing in the blood vessels.In addition, the patient for receiving blood flow guiding device must be for a long time Using anticoagulant to prevent hemostatic tube thrombosis.Endovascular device also aims to the circulation in cutting aneurysm, minimizes simultaneously Amount of metal in blood vessel simultaneously substantially reduces or eliminates needs to blood-clotting agent.The device of these types can also be easier in lesion Position tracking and/or deployment.

Device disclosed herein and system in aneurysm rather than carry tumor by using single device sealing aneurysm neck These and other disadvantages of prior method are solved in blood vessel.Fig. 1 is gone to, the example woven 10 of the disclosure is shown as disposing It is discharged in the aneurysm A of blood vessel BV but not yet from delivery system 40.Delivery system 40 may include that delivery tube 30 is slideably set It sets in microtubular 20 wherein.As shown in Figure 1, braided fabric 10 can be mobile from the collapsed state in microtubular 20 by delivery tube 30 To the unfolded state in 20 distal side of microtubular.The distal end 34 of delivery tube 30 can be attached to braided fabric 10 by lock part 54 Proximal end 16, it is as follows to be more specifically described.

In Fig. 1, microtubular 20 is already delivered to the neck of aneurysm A, and by the distal expandable of braided fabric 10 The distal side capsule that part 12 is formed is shown as filling aneurysm A.It part 12 can be from distal side capsule radial dilatation at predetermined Shape and structure, the shape and structure draw the profile of the wall of aneurysm A and the wall of aneurysm A.For example, part 12 is remote Side capsule can be shaped as spherical shape, saddle type, ellipse or any other shape.The distal side capsule of part 12 is also possible to collapsible cage Shape vascular occlusion structure.The annular expansion section 3 formed by proximal expandable part 13 is also shown, part 13 is close part 12 Side.Section 3 can be formed around the neck of aneurysm A.In some embodiments, section 3 can be used for being located in aneurysm A's In neck and seal.Section 3 can be by single continuous part (for example, single integrally formed net) or multiple individual discrete portions (for example, multiple discrete portions can be expanded and extend from the proximal end 16 of braided fabric 10) is formed.

When being moved to unfolded state, part 13, which can be expanded and be formed, to be surrounded and/or surrounds under distal side capsule part 12 The annular expansion section 3 of proximal end.For example, annular expansion section 3 can surround and/or surround the formation of conical section 5, which can To be located between part 12 and 13.Although illustrating only part 12 and 13 and conical section 5 interconnecting, as needed or require It may include any amount of additional expandable part and/or section.How thin braided fabric 10 is by the multiple self expandables that can be formed by the network Silk section is formed.Braided fabric 10 can also include buckle portion, for promoting collapse shape of the part 12 and/or 13 inside aneurysm State is expanded to unfolded state.One or more buckle portions can be positioned between part 12 and 13, including on conical section 5 or its Around.Braided fabric 10 can also have open distal end 14 associated with section 12, and proximal end associated with section 13 Portion 16, the proximal end are intended to be located on the neck of aneurysm A or near it.End 16 can also be attached to lock part 54, which is configured as and the distal end 34 of delivery tube 30 is releasedly attached.

The net of braided fabric 10 can be by one or more net patterns, one or more discrete mesh portions (including 12 He of part 13 and/or conical section 5) and/or one or more net limited openings for being limited by braiding filament.For example, the net of braided fabric 10 can Including pore region associated with the distal side capsule of part 12, and another pore region associated with the section 3 of part 13. In some embodiments, the porosity of part 12 is smaller than the porosity of part 13.However, braided fabric 10 is without being limited thereto, compile The other parts of fabric 10 can have its porosity, and other knitting properties are as needed or require and change.For example, portion Dividing 13 may include the porosity of the porosity lower than conical section 5.The corresponding porosity of the various pieces of braided fabric 10 can pass through Change gap, braid angle, heat treatment, net opening, covering and/or the size that waits to limit.For example, shown in Fig. 1 to Fig. 2 B The net of braided fabric 10 may include and each section 12,13 associated Different porosities regions.In practice, the hole of part 12 Rate allows its external distal side capsule to take on any of a number of shapes before, during or after being delivered to aneurysm.

In some embodiments, section 3 can covering part 12 in the deployed state distal side capsule.For example, working as braided fabric 10 by delivery tube 30 distad translated from microtubular 20 when, section 3 can be with the outer surface of the distal side capsule of covering part 12.Work as braiding When object 10 is pushed against on aneurysm wall, it is also possible to the expansion of part 12 and 13 occur.When braided fabric 10 is expanded to unfolded state When, the outer end of the distal side capsule of part 12, which can also be orientated to, is pressed against annular expansion section 3.It illustratively " presses " shown in Fig. 1 It is shown in orientation, thus when section 12 is pressed against on the inner surface of the ring segment of part 3, sky can be formed between section 3 and distal side capsule Gap or cavity 9.The gap or cavity 9 can be used as " air cushion ", so that when braided fabric to be pushed in aneurysm A towards distal side, by In part 12 and 13 be pushed into another and flexibly conform to aneurysm A shape and have certain administered dose, therefore Avoid rupture.

The net of braided fabric 10 may include pipe, and proximal end 16 is open at opposite distal end 14.Proximal end 16 can also be closed and be attached to lock part 54.Braided fabric 10 can be made of different materials, the film or list such as deposited One material.The net of braided fabric 10 may include more lines, such as 4 to 96 lines.The quantity of line can be the material of control braided fabric 10 The factor for expecting characteristic, including shape, flexibility, the rigidity etc. under porosity, unfolded state.When the line for the net for determining braided fabric 10 When number, it may be considered that the combination of the distal side capsule of part 12 and the annular expansion section 3 of external covering, because of capsule base in the deployed state It is located inside annular expansion section 3 in sheet.In addition, the distal side capsule of section 12 and/or the annular expansion section 3 of part 13 can be can together The caged vascular occlusion structure collapsed.

The line of braided fabric 10 can be by the Nitinol with the intertexture platinum filament for radiopacity or with 10% to 40% Stretching filling pipe (DFT) Nitinol of platinum is made.Line can be by Nitinol, cochrome, stainless steel, tantalum and/or other alloys And/or the combination of any other suitable biocompatible material or these materials is made.Moreover, these materials can be with the time Passage is absorbed by the patient or can not be absorbed by the patient.In this respect, first porosity associated with part 12 is smaller than part 13 porosity.Section 12,13 is arranged to unfolded state, changes braided nature, and/or section 12 is positioned to and aneurysm Neck is adjacent or connection, can be conducive to overturn, reverse and/or slow down into aneurysmal flowing.

The hole of the net of entire braided fabric 10 can also form the frame or net of basic one.Therefore, Kong Kewei any size, shape Shape or porosity, and can be evenly or randomly spaced apart in the net wall of entire braided fabric 10.Hole can provide with flexibility Braided fabric 10, and additionally aid the unfolded state that net is transformed into expansion from collapsed state, vice versa.

In certain embodiments, one or some braid angle in part 12,13 or conical section 5 can also change. The linear diameter of braided fabric 10, thread count (that is, line number of crossovers of each linear measurement) can also the position of braided fabric 10 it Between change or otherwise modify, to change device characteristic and heat set shape.The fiber of braided fabric 10 can by via Hot adhesion (passing through laser or ultrasonic bonding), solvent or adhesives, crimping or any other means for attachment are in its freedom End is fixed and is formed.The fiber of braided fabric 10 can by solvent, adhesive or hot adhesion (such as laser, ultrasonic bonding or Any other heat source) inside it intersection bonded.However, braided fabric 10 is not limited to this and it can have braiding Angle, pitch number, linear diameter, porosity or braided fabric 10 any other characteristic substantially similar always.

Fig. 2A is gone to, example woven 10 is in collapsed state in microtubular 20, and before being disposed with aneurysm A It is connected to delivery tube 30.Fig. 2 B depicts the braided fabric 10 of Fig. 2A, is connected to delivery tube 30 and is arranged in microtubular 20 The unfolded state in distal side.Delivery system 40 may include the microtubular 20 that delivery tube 30 is arranged slideably therein.Microtubular 20 It can be previously positioned at the level of aneurysm neck, and for tracking device to aneurysm.The size of microtubular 20 is contemplated that dynamic Arteries and veins tumor or microtubular 20 must be by being selected with the size, shape and the directionality that reach the features of therapentic part.Microtubular 20 can be anywhere with 80 centimetres to 170 centimetres of total length available.Anywhere microtubular 20 can have 0.015 English It is very little with 0.032 inch between internal diameter ID.The size of outer diameter OD can also change and can be at its proximal end or distal end Narrow.At its proximal end 26, microtubular 20 can be operated with hand, and can be operated at its distal end 24 to position In the neck of aneurysm A.And the distal end 24 of microtubular 20 as shown in the figure includes braided fabric 10,24 variable shape of end And it can be bent at a certain angle.

Delivery tube 30 can be substantially elongated, and can extend to distal end from the proximal end 26 of microtubular 20 24.Pipe 30 can usually extend along the inner cavity of microtubular 20, and can between its outer surface and the inner surface of microtubular 20 there are Space.Then, delivery tube 30 and microtubular 20 can be axially aligned.System 40 can be used microtubular 20 that braided fabric 10 is delivered to sense Location of interest (for example, diseased region).In certain embodiments, microtubular 20 can be previously positioned at the level of aneurysm neck Place and for for example arriving lesion by tracking associated with lock part 54 radiopaque element to track braided fabric 10.It passs Send pipe 30 that can be mechanically connected at lock part 54 with braided fabric 10.As follows shown more particularly, lock part 54 may include Pusher ring.

Braided fabric 10 can be by slidably attachment, permanent attachment part (for example, curling, laser, ultrasonic welding or other heat Source, adhesive etc.) or other attachment methods be attached to lock part 54, it is as follows to be more specifically described.When delivery tube 30 exists It when being attached to braided fabric 10 at lock part 54, is translated to the far side, slides or otherwise moving tube 30 can towards aneurysm A Braided fabric 10 is set to start the ring for being moved to the distal side capsule of the part 12 with formation, part 13 from the collapsed state in microtubular 20 Unfolded state outside the microtubular 20 of shape expansion segment 3 and/or the conical section 5 being disposed there between.

As shown in Figure 2 B, the capsule of corresponding part 12 is formed now, and the annular expansion part 3 of part 13 is arranged in portion Divide 12 nearside and outer side covering.Proximal end 16 is still connected to delivery tube 54 via lock part 30.In fig. 2b, distal side End 14 can form the outer layer of the distal side capsule of part 12, and proximal end 16 can form the annular expansion section 3 of part 13 Outer layer.

Fig. 3 is gone to, the amplification schematic side elevation of the braided fabric 10 of Fig. 1 to Fig. 2 B is shown with the expansion state of feature.Such as Shown in figure, part 12 has expanded into the nearside taper of approximately spherical distal side capsule and the annular expansion section 3 for leading to part 13 Conical section 5.The net characteristic of braided fabric associated with part 12,13 and/or conical section 5 includes porosity and flexibility, they It can change, wherein porosity is minimum, and flexibility is maximum, preferably at the part of aneurysm neck 13.For example, because part 12 and 13 expansion shape forms their own predetermined shape (see, for example, the distal side of part 12 in aneurysm A Capsule), therefore the part (such as part 13) of the braided fabric 10 in proximal end 16 or near it can be than in proximal end 14 The part (such as part 12) of braided fabric 10 upper or near it is more flexible, to induce self-aggrandizement during delivering.However, Braided fabric 10 is without being limited thereto, and can according to need or part 12,13 and/or section 5 appointing using flexibility and/or porosity What is combined.Filament in other porosity regions of braided fabric 10 can also have constant thread count over the whole length.

Braided fabric 10 can be by having the Nitinol of the intertexture platinum filament for radiopacity to be made.When device 10 is opened up completely When being opened in aneurysm A, the conical section 5 between part 12 and 13 can permit corresponding part and expand, to form part 12 Distal side, and surround the annular expansion section 3 of part 13.In order to promote the expansion of braided fabric 10 and/or the annular expansion of part 13 The formation of section, braided fabric 10 can be modified to be weakened at section 5, to promote section 13 to surround the reversing of section 12.For example, section 5 It may include pre- weakening part, which includes local braid angle variation, the removal of line segment, local heat treatmet and/or change braiding The other methods of object characteristic.In certain embodiments, the braid angle of part 13 can be relative to the other parts of braided fabric 10 (including part 12) reduces, so that flowing can be deflected, turns to and/or be slowed in aneurysm.This is because when part 12 and/ Or 13 expansions and braided fabric 10 in aneurysm A when being unfolded in aneurysm A, part 13 can be configured for and aneurysm The neck of A is connected to, because end 16 can be stuffed into part 13 (for example, with reference to Fig. 6 A) during delivering.

The diameter of braided fabric 10 and braiding line number can the diameters of the device according to needed for treatment particular aneurysm and/or required Porosity and change.For example, the predetermined shape of the annular expansion section 3 for the distal side capsule and part 13 of inducing moiety 12 With the formation of intensity, end 14 can be more flexible than end 16, or vice versa, and the other positions (example of braided fabric 10 Such as, conical section 5) it can become most flexible from end 16 or near the end, and it is attached on end 14 or in the end Closely become less flexible.In some embodiments, 14 braiding thread end can be surround each other, this is particularly advantageous to ensure to compile Fabric 10 is hurtless measure in the dome contacts with aneurysm A.

In order to form or assemble braided fabric 10 as shown in Figure 1 to Figure 3, lock part 54 may be coupled to end 16 and/ Or it is folded on the end.Braided fabric 10 is without being limited thereto, and end 16 can be welded by sound wave, mechanical attachment or adhesive can It is operatively connected lock part 54 or its any feature.Regardless of connecting, proximal end 16 is operably connected to sticking department 54 are divided to may make to form the outer layer of braided fabric 10 associated with section 12.

Fig. 4 is the amplification schematic side elevation of the substitution braided fabric 10a before assembling with microtubular 20 and delivery tube 30. In this embodiment, braided fabric 10a may include alternative part 12a, have the section 5a being arranged with center and part 13 opposite Open or closed distal end 14a.Part 12a as shown in the figure can be simple tubulose and/or cylindrical cross-section, It is designed to expand in a manner of being similar to coil and occupies the space inside aneurysm A.Between the net feature of part 12a and 13 Difference be visible.It can also be seen that the section 3 of the part 13 in the embodiment may include hurtless measure outer end, this is noninvasive Hurt outer end and is configured as expanding and being pressed against during delivering aneurysm wall without destroying aneurysmal risk.Lock part 54 It can be set at the proximal end 16 of braided fabric 10a, and including radiopaque element, in order to accurately track lesion Position.The meander-shaped of discribed part 12a and 13 is only exemplary in the illustrated embodiment, and can be according to need Want or require any shape of any feature using the braided fabric 10a including part 12a and 13.

In practice, as shown in Fig. 5 A to Fig. 6 B, braided fabric 10 can be pushed into aneurysm A by delivery tube 30, and The neck across aneurysm A is unfolded together with the relatively low porosity outer layer of part 13.Before the arrangement of Fig. 5 A, braided fabric 10 can To be fitted together with the delivery tube 30 and/or microtubular 20 for being in collapsed state, and therefore it is arranged in inside microtubular 20.In This respect, delivery system 40 and braided fabric 10 can be packaged as Portable kit or system.Microtubular 20, delivery tube 30 and/or Assembling between braided fabric 10 can carry out before being introduced into vascular.The delivery system 40 being used together with braided fabric 10 may include Microtubular 20 and delivery tube 30, are selectively positioned in diseased region, and delivery tube 30 can start to aneurysm towards distal side Translate braided fabric 10.

In fig. 5, there is delivery tube 30 braided fabric 10 distad translated to enter aneurysm A.Part 12 has begun court To the outer wall radial dilatation of aneurysm A, and microtubular 20 is left in unexpanded part 13 and is inserted at neck or near neck Inside aneurysm A.In addition, the part of the braided fabric 10 at end 16 or near it is collapsed inside microtubular 20.It can see Start to expand outwardly from the wall that central shaft is outwardly directed to aneurysm A to the annular expansion section 3 in Fig. 5 A, and the distal side of part 12 Capsule is expanded in the distal side of section 3.Section 5 is illustrated at the basic tubulose of its predilation state in fig. 5.However, in figure 5B, When delivery tube 30 is distad deeper moved in aneurysm A, the distal side capsule and annular expansion section 3 of part 12 continue around section 5 and distal side capsule 12 expansion and reverse.In Fig. 5 A to the movement between 5B, shows section 3 and surround and/or surround the remote of part 12 The lower end of side capsule is formed.Also show the distal side capsule of 3 covering part 12 of section because braided fabric 10 distad deeper move to it is dynamic In arteries and veins tumor, and the end 14 of braided fabric 10 is pushed against on aneurysm wall.When braided fabric 10, which distad inclines, translates deep, scheming As can be seen that the outer end of section 12 begins to press against ring segment 3 in 5B.

Fig. 6 A is gone to, since section 3 is reversed around section 5, gap or cavity 9 are formd between section 3 and distal side capsule.The gap Or cavity 9 may be used as further preventing " air cushion " of rupture.Lock part 54 is depicted as near or adjacent to microtubular 20 End 24, so that all parts of braided fabric 10 are all in its distal side and in the outside of microtubular 20.Therefore, section 3 is completely Expansion, distal end are pressed into the capsule of distal side.Section 3 proximal face can be it is curved or have profile, with aneurysm A Neck be connected to and be used as flow diverters.It should be appreciated that braided fabric 10 can be by having the intertexture platinum filament for radiopacity Nitinol be made.Delivery tube 30 can be driven by hypotube from its proximal end 36 by operator is equal.It is micro- during delivering Conduit 20 can keep opposing stationary or fixed, and can be seen that delivery tube 30 towards the neck of aneurysm A and pass through the neck towards remote Side translates braided fabric 10.As shown in Figure 6A, the further distal translation of delivery tube 30 can be essentially such that lock part 54 The cone angle of section 5 is bigger, and the expansion of 3 surrounding portion 12 of section and/or amount section 3 is compressed against there.Then, part 54 is substantially It fills in braided fabric 10, to make the section 3 that more profile is flattened or otherwise presented relative to aneurysmal neck.

Also it can be seen that being moved between Fig. 5 A to Fig. 6 A, end 16, lock part 54 and the delivery tube 30 of braided fabric 10 it Between interconnecting piece can be moved to out of microtubular 20 in the aneurysm A for being completely in unfolded state in the collapsed state.Once compiling Fabric 10 is selectively positioned, and the part 12 and 13 including being in its unfolded state, braided fabric 10 can be torn open from delivery tube 30 Under, as shown in Figure 6B.In other words, when braided fabric 10 is translated to the far side to the dome of aneurysm A, part 12,13 is expansible, The aneurysm wall in a manner of easy, effective and avoid risk of rupture.

Once expansion and positioning, delivery tube 30 can proximally translate back microtubular 20 and contract from braided fabric 10 and aneurysm A It returns.Fig. 6 B shows exemplary arrangement of the braided fabric 10 under its unfolded state, and part 12 and 13 is moved respectively to its expansion Configuration and lock part 54 is removed from delivery tube 30.Part 12,13 and/or lock part 54 are expanded in braided fabric 10 It is particularly advantageous, because it can prevent braided fabric 10 from generating protrusion, otherwise the protrusion, which may extend to, is carried in tumor blood vessel.Phase Instead, any such protrusion can be stuffed into braided fabric 10 now.It is same across aneurysmal neck arrangement braided fabric 10 in this way When the also porosity of changing section 12,13 can be also oriented in the intracapsular formation blood flow of braided fabric 10.Fig. 6 B illustrates only part 12 Example spherical shape distal side capsule and example annular expansion section 3, formed completely in a manner of being enough to occlude aneurysm A.However, if Part 12 or 13 is not accurately positioned or needs to reset or adjust in aneurysm A to be occluded safely without generating rupture Risk, then braided fabric 10 can be retracted into microtubular by proximally extracting delivery tube 30 out when being still attached to braided fabric 10 In 20.

Fig. 7 A to Fig. 8 B generally shows the attachment of the example between delivery tube 30 and braided fabric 10 and delivering, for dynamic It is unfolded and removes braided fabric 10 in arteries and veins tumor A.The embodiment of Fig. 7 A to Fig. 8 B is only that delivery tube 30 and braided fabric 10 can be A kind of mode being attached at end 34, and as needed or requirement is it is contemplated that any amount of attachment means.As shown in the figure The cavity that can have proximally end 36 to extend to distal side delivering end 34 of delivery tube 30.Fig. 7 A is shown and locking component 52 The braided fabric 10 of engagement and the loop wire 58 for locking lock part 54.It may pass through the opening 60 that loop wire 58 is placed in lock part 54.Lock The form that part 54 preferably uses minor diameter elongate filament is determined, however, the other forms such as line or tubular structure can also be with It is suitable.Although lock part 54 is preferably formed by Nitinol, such as stainless steel, PTFE, nylon, ceramics or glass fibers Other metals such as dimension and compound and material are also possible to suitably.In one example, locking component 52 can for it is elongated can Retracting fibers can extend between the end of microtubular 20 24 and end 26.Locking component 52 is preferably thin using minor diameter The form of essentially continuous fine thread, however, the other forms such as line or tubular structure are also possible to suitably.Although locking component 52 is preferred Ground is formed by Nitinol, but other metals and material such as stainless steel, PTFE, nylon, ceramics or glass fibre and compound It is suitable to be also possible to.When locking component 52 passes through opening 60, braided fabric 10 is fixed now.It should be appreciated that delivery tube 30 may include the compressible portion 38 being arranged between its end 34 and end 36.

Compressible portion 38 allows delivery tube 30 to be bent and/or bend.This flexibility can be helped through microtubular 20 Track braided fabric 10 and the zigzag path by vascular system.Compressible portion 38 can be formed with interference helical cuts, the interference Helical cuts have allowed gap to allow to be bent, but in one example, it is not used as helical cut spring.Compressible portion 38 can be adjusted axially between elongation state and compressive state.However, any other arrangement for allowing to be adjusted axially is (for example, twine Coiling or hurricane band) it can also be suitble to be used together with according to the separation system of the disclosure.Unless otherwise limitation, otherwise compressible part Points 38 can be at elongation state when static and automatically or return resiliently to elongation state from compressive state.Herein more in detail Carefully describe the function of compressible portion 38.

In fig. 7, power F is previously applied so that delivery tube 30 is placed in compressive state.Fig. 7 B, which is shown, proximally pulls locking Component 52 is with the release sequence for the object 10 that takes up one's knitting.Fig. 8 A shows locking component 52 and leaves opening 60 and be drawn out loop wire 58 Moment.62 disengaging of distal end of loop wire 58/return to its preforming shape and leave lock part 54.As can be seen that not having now There is anything that braided fabric 10 is remained to delivery tube 30.Fig. 8 B shows the end of release sequence.Here, delivery tube 30 can Compression section 38 is expanded/and it is restored to its original-shape and " pops up " forward.From the distal end 34 of delivery tube 30 to volume Fabric 10 applies elastic force E to leave its " promotion ", to ensure clean separation and braided fabric 10 is delivered to aneurysm A.It should Understand, delivering scheme described in Fig. 7 A to Fig. 8 B is only the exemplary method for delivering braided fabric 10.

Fig. 9 is the flow chart that locking device is delivered to aneurysmal method 900.Step 905 includes by the close of braided fabric Side end is attached to the distal end of delivery tube.Step 910 includes that microtubular is selectively located in vascular system (example Such as, in aneurysmal neck).Step 915 includes that braided fabric and the delivery tube of attachment are located in microtubular.Step 920 packet It includes and is distad slided braided fabric towards aneurysm from microtubular by delivery tube, to make the distal expandable inside aneurysm Part is expanded, and to form distal side capsule, and circularizes expansion segment around distal side scrotiform at the proximal end of braided fabric.Step 925 include release braided fabric, may include annular expansion section and distal side capsule.Step 930 includes that delivery tube is taken out from aneurysm And microtubular.

In certain embodiments, method 900, which may also include by forming distal side capsule, fills aneurysm.In some implementations In scheme, the selectivity positioning of braided fabric includes that the distal end of microtubular is placed on aneurysmal neck.In some implementations In scheme, distal expandable part is expanded simultaneously in the formation of annular expansion section.

In certain embodiments, method 900 further includes that lock part is attached to the proximal end and delivering of braided fabric The distal end of pipe；And pass through lock part release delivery pipe from braided fabric.In certain embodiments, method 900 is gone back Including expanding annular expansion segment, so that the outer surface of annular expansion section covering distal side capsule.In certain embodiments, method 900 It further include that annular expansion section is pressed against in one or more outer ends of distal side capsule when braided fabric distad moves in aneurysm. In certain embodiments, method 900 includes when annular expansion section is reversed around distal side capsule, in annular expansion section and distal side capsule Between form gap or cavity in certain embodiments, method 900 is included in proximal expandable part and distal expandable portion / formation conical section.

In certain embodiments, method 900 further include make proximal expandable part porosity be less than conical section and/or The porosity of distal expandable part；Proximal expandable section is positioned to or connection adjacent with aneurysmal neck；And deflection, It turns to and/or slows down into aneurysmal flowing.This method 900 can also include being less than the flexibility of proximal expandable part The flexibility of conical section and/or distal expandable part；Proximal expandable section is positioned to adjacent with aneurysmal neck or is connected It is logical；And it deflects, turn to and/or slows down into aneurysmal flowing.

In some embodiments, it discloses and a kind of treats aneurysmal method 1000 using braided fabric.Step 1005 can Including braided fabric is moved distally in aneurysm.Step 1010 may include by the proximal expandable part of braided fabric from collapsing State is expanded to expansion state, to seal aneurysmal neck.Step 1015 may include in aneurysm interior expansion braided fabric Distal expandable part, to form distal side capsule, to fill aneurysm.

In certain embodiments, step 1015 may include circularizing at the proximal end of braided fabric around distal side scrotiform Expansion segment.In some embodiments, method 1000 may include making annular expansion section around the overlapping of the outer surface of distal side capsule and falling Turn.In some embodiments, method 1000 may include when annular expansion section around distal side capsule reverse when, annular expansion section with Gap or cavity are formed in some embodiments between the capsule of distal side, and method 1000 may include in proximal expandable part and distal side Conical section is formed between expandable part.Method 1000 can also include that the porosity of proximal expandable part is made to be less than conical section And/or the porosity of distal expandable part；And it deflects, turn to and/or slows down into aneurysmal flowing.This method 1000 It can also include the flexibility for making the flexibility of proximal expandable part be less than conical section and/or distal expandable part；And It deflects, turn to and/or slows down into aneurysmal flowing.

It should be appreciated that the modification of braided fabric 10 may include a variety of materials, such as stainless steel, bioabsorbable material and polymerization Object.Braided fabric 10, including any specific part, such as any fracture, the different zones of different porosities and occlusion capsule, Ke Yire It is shaped as various configurations, spherical shape, ellipse, saddle type etc., for shaping distal side capsule and/or other expansion segments, with more preferable Ground matches aneurysm morphology.In addition, braided fabric 10 can be thermoformed into including weak spot, be conducive to distal side capsule and/or its The radial dilatation of his expansion segment.In addition, forming the gap of distal side capsule and/or the braided fabric 10 of other expansion segments can change, or Person can selectively design size or shape along its length, this depends on making braided fabric 10 as delivery tube 30 is moved distally How much is expansion.

It should be appreciated that braided fabric 10 can also include being connected in systems or otherwise with imaging device, the imaging Device can be such that the distal side capsule of braided fabric 10 and/or other expansion segments is imaged relative to aneurysm.By braided fabric 10 relative to Aneurysm distally and proximally moves, and passes through the radiopaque features of one or more of braided fabric or attached by imaging device It is connected to and accurately monitors thereon, the orientation of distal side capsule and/or other expansion segments can be adjustable.

The size and shape of specific configuration, the selection of material and various elements can according to need according to disclosed skill Art principle construction system or method specific design specification or constraint and change.These changes are intended to be included in disclosed In the range of technology.Therefore, disclosed embodiments of the present invention are considered to be illustrative rather than limitation in all respects Property.Therefore, although from foregoing teachings it is readily apparent that the particular form of the disclosure has been shown and described, In the case where not departing from the spirit and scope of the present invention, various modifications can be carried out, and in the meaning and scope of its equivalent Interior all changes, which are intended to, to be included in.