阅读说明：本技术 用于除皱的药物组合物及其应用 (Pharmaceutical composition and its application for smoothing wrinkle ) 是由 朱盼盼 沙薇 李婷 金小小 于 2019-10-12 设计创作，主要内容包括：本发明涉及药物领域,特别涉及用于除皱的药物组合物及其应用。该组合物包括乌梅提取物、五味子提取物、赤芍提取物、柠檬酸、没食子酸,可加入药学或化妆品领域中常用的辅料或辅助性成分中,制备成凝胶剂、贴剂、软膏等。本发明的组合物能促进皮肤细胞代谢,提高皮肤天然保湿能力,长期使用具有减少或消除细小皱纹、安全无毒副作用等优点。(The present invention relates to drug fields, in particular to are used for the pharmaceutical composition and its application of smoothing wrinkle.The composition includes smoked plum extractive, Schisandra chinens P.E, red paeonia extract, citric acid, gallic acid, can be added in pharmaceutically or cosmetically field in common auxiliary material or complementary ingredient, be prepared into gelling agent, patch, ointment etc..Composition of the invention can promote skin cell metabolism, improve skin natural moisture preserving ability, and long-time service has many advantages, such as to reduce or eliminate fine wrinkles, safe without toxic side effect.)

1. a kind of composition, which is characterized in that in parts by weight, including following component:

2. composition as described in claim 1, which is characterized in that in parts by weight, including following component:

3. composition as described in claim 1, which is characterized in that in parts by weight, including following component:

Or

Or

4. the preparation method of composition as described in any one of claims 1 to 3, which comprises the steps of:

The preparation of smoked plum extractive: taking dark plum raw medicine, after being crushed, being sieved, extraction is mixed with ethanol water, is collected after filtering Filtrate is concentrated, and smoked plum extractive is made in vacuum drying；

The preparation of nutgall extractive: taking Chinese gall raw medicine, and after crushing, extraction is mixed with water, and filtering and collecting filter liquid is concentrated, Nutgall extractive is made in vacuum drying；

The preparation of red paeonia extract: taking radix paeoniae rubra raw medicine or medicine materical crude slice, and after crushing, extraction is mixed with acidic aqueous solution, and alcohol precipitation is stood, and is received Collection precipitating is vacuum dried, and red paeonia extract is made in sieving.

5. preparation method as claimed in claim 4, which is characterized in that in the preparation of smoked plum extractive, in terms of g/mL, dark plum is former The mass volume ratio of medicine and ethanol water is 1:(25~35)；The concentration of ethyl alcohol is 80~90% in the ethanol water (v/v)；

In the preparation of nutgall extractive, in terms of g/mL, the mass volume ratio of Chinese gall raw medicine and water is 1:(10~20)；

In the preparation of red paeonia extract, in terms of g/mL, the mass volume ratio of radix paeoniae rubra raw medicine or medicine materical crude slice and acidic aqueous solution is 1:(6 ~10)；The pH value of the acidic aqueous solution is 2.

6. preparation method as described in claim 4 or 5, which is characterized in that in the preparation of smoked plum extractive, the temperature of the extraction Degree is 60~80 DEG C, and the time of the extraction is 2~4h；

In the preparation of nutgall extractive, the temperature of the extraction is 100 DEG C, and the time extracted every time is 1~3h, the extraction Number be 2~4 times；

In the preparation of red paeonia extract, the temperature of the extraction is 15~35 DEG C, and the time extracted every time is 1~2h, described to mention The number taken is 2~4 times.

7. such as the described in any item preparation methods of claim 4 to 6, which is characterized in that described dense in the preparation of smoked plum extractive It is condensed to be concentrated into density in 60~65 DEG C to be 1.0~1.5g/cm³；

In the preparation of nutgall extractive, the concentration is 1.0~1.1g/cm to be concentrated into density in 60~65 DEG C³；

In the preparation of red paeonia extract, the concentration is 1.15~1.18g/cm to be concentrated into density in 60~65 DEG C³；The alcohol Calmness is set to: 95% ethyl alcohol of 3-5 times of weight of enriched product is added, stirs 20~50min, stands 8~16h.

8. such as the described in any item preparation methods of claim 4 to 7, which is characterized in that the vacuum drying vacuum degree is- 0.075~-0.085Mpa, temperature are 60 DEG C, moisture content < 9%.

9. composition as described in any one of claims 1 to 3 or such as described in any item preparation method systems of claim 4 to 8 Application of the composition obtained in the drug and/or cosmetics of preparation smoothing wrinkle.

10. drug or cosmetics, which is characterized in that wanted comprising composition as described in any one of claims 1 to 3 or such as right Ask composition made from 4 to 8 described in any item preparation methods and acceptable auxiliary material.

Technical field

The present invention relates to drug fields, in particular to are used for the pharmaceutical composition and its application of smoothing wrinkle.

Background technique

The aging of population is global trend, and after aging is most significantly the variation of skin appearance, therefore delays skin The Related product of skin aging is especially attracted attention.Wrinkle is one of feature of skin aging, and causes the risk factor of wrinkle normal Have:

1, mental element: feeling bad, it is unsmooth to will lead to human qi and blood running, often depressed, irritable, unsociable and eccentric, or Distress, anxiety, overcautious expression usually are shown in face, affects mimetic muscle to be easy for generating vertical or horizontal wrinkle, makes There is evidence for senescence in people.

2, bad life habits: often having not enough sleep, smoke, lack exercise, and can all make metabolism and the tune of skin It is impaired to save function, causes in a sorrowful look, causes skin aging, generate wrinkle.

3, water deficient: water is that the important component part of skin and skin carry out the indispensable object of metabolism institute Matter basis.In general, if moisture content of skin is lower than 10%, drying regime will be presented, make pachylosis, relaxation, the time is long Wrinkle also just produces

4, solar exposure: being exposed to the sun in the sun can make skin dry out, is thinning, follow the string for a long time, if keeping elastic force fine Peacekeeping cutin fiber loses normal function, then skin also can gradually fluff, wrinkle.

5, improper diet: chronic dietary is uneven, nutrition condition is bad, and skin and musculature just also can be malnutritive, Caused pachylosis and relaxation can accelerate the generation of wrinkle.

6, cosmetics improper use: can destroy the quality of skin using unsuitable cosmetics, skin fiber is caused to reduce, , there is wrinkle at flexibility decrease in moisture content of skin decline.Blocked up foundation emulsion can similarly make face fine and closely woven small wrinkle occur.

To other than sun-proof, life of keeping fit, maintain moisture content of skin in 10% to prevent and improving wrinkle More than and skin care, pre- anti-wrinkle generate important step.The water content of healthy skin should maintain 15~20% left sides The right side, the too low sensibility skin easy to form of moisture content of skin, and water content is at least wanted 30% or more just skin can be made to reach sparkling and crystal-clear Exquisitely carved effect.Therefore maintain the moisturizing step of moisture content of skin whether in the maintenance such as wrinkle resistant, anti-ageing or in reduction skin Important role is all played in allergy.

In addition, the aging phenomenon as caused by ultraviolet light is known as light aging, it can be living via mitogen (mitogen) Change the phosphorylation of protein kinase (protein kinase) approach and increases the matrix metalloproteinase (matrix of skin corium Metalloproteinase, MMP) amount.Matrix metalloproteinase can decompose collagen to reduce the collagen egg in skin Bai Hanliang.If skin has lacked the support of collagen, relaxation can be become and followed the string, and cause cuticula hyperplasia, wrinkle Increase.The animal collagen having now been found that is there are about a kind of 20 patterns, wherein most with the content of the first collagen type, It is also the most wide collagen of function.There is different collagens according to different tissues.In skin histology, the first Collagen Type VI egg It is white to account for about 80%, and third collagen type accounts for about 20%.Therefore, if matrix metalloproteinase can be inhibited to be especially the first type Activity and/or the effect of reduce its generation, that is, can reach improvement/enhancement skin quality.

Currently, the appearance for mitigating skin defect, such as the means of wrinkle, microgroove include invasion and Non-Invasive skill Art.Aggressive techniques are for example performed the operation, filler, laser surface are rebuild or can provide more longlasting effect and can treat protrusion Defect.And the example of non-invasive method include by by foundation cream type makeup application to skin or coating include can be at any time Mitigate the cosmetic formulation (for example, anti-wrinkle creme) of the ingredient of the appearance of defect and conceals defects.Regrettably, foundation make-up It is not durable, and the appearance of significant skin defect, such as deep wrinkle cannot be mitigated, and containing the appearance that can mitigate defect at The cosmetic formulation needs divided take a long time and could work, and more apparent skin defect is not acted on.Especially Ground, many existing cosmetic formulations are without mechanical performance needed for capable of beautifying notable defect.

Considered based on safety and natural sex, has been attempted at present by developing anti-aging preparation in natural products.So according to now Trend, still a need to develop the skin care smoothing wrinkle product of natural, safe muting sensitive and tool more preferably effect.

Summary of the invention

In view of this, the present invention provides a kind of pharmaceutical composition and its application for smoothing wrinkle.The composition, which has, to be promoted Skin cell metabolism improves skin natural moisture preserving ability, and with reducing or eliminating, fine wrinkles, irritation are small, pacify for long-time service The advantages that completely without toxic side effect.

In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:

The present invention provides a kind of compositions, in parts by weight, including following component:

In some specific embodiments of the invention, in parts by weight, including following component:

In some specific embodiments of the invention, in parts by weight, including following component:

Or

Or

On the basis of the studies above, the present invention also provides the preparation methods of the composition, include the following steps:

The preparation of smoked plum extractive: taking dark plum raw medicine, after being crushed, being sieved, extraction is mixed with ethanol water, after filtering Filtrate is collected, is concentrated, smoked plum extractive is made in vacuum drying；

The preparation of nutgall extractive: taking Chinese gall raw medicine, after crushing, extraction is mixed with water, filtering and collecting filter liquid is dense Nutgall extractive is made in contracting, vacuum drying；

The preparation of red paeonia extract: taking radix paeoniae rubra raw medicine or medicine materical crude slice, after crushing, extraction is mixed with acidic aqueous solution, alcohol is peaceful It sets, collects and precipitate vacuum dried, sieving, obtained red paeonia extract.

In some specific embodiments of the invention, in the preparation of smoked plum extractive, in terms of g/mL, dark plum raw medicine and second The mass volume ratio of alcohol solution is 1:(25~35)；The concentration of ethyl alcohol is 80~90% (v/v) in the ethanol water；

In the preparation of nutgall extractive, in terms of g/mL, the mass volume ratio of Chinese gall raw medicine and water is 1:(10~20)；

In the preparation of red paeonia extract, in terms of g/mL, the mass volume ratio of radix paeoniae rubra raw medicine or medicine materical crude slice and acidic aqueous solution is 1:(6~10)；The pH value of the acidic aqueous solution is 2.

In some specific embodiments of the invention, in the preparation of smoked plum extractive, the temperature of the extraction is 60~ 80 DEG C, the time of the extraction is 2~4h；

In the preparation of nutgall extractive, the temperature of the extraction is 100 DEG C, and the time extracted every time is 1~3h, described The number of extraction is 2~4 times；

In the preparation of red paeonia extract, the temperature of the extraction is 15~35 DEG C, and the time extracted every time is 1~2h, institute The number for stating extraction is 2~4 times.

In some specific embodiments of the invention, in the preparation of smoked plum extractive, the concentration is in 60~65 DEG C Being concentrated into density is 1.0~1.5g/cm³；

In the preparation of nutgall extractive, the concentration is 1.0~1.1g/cm to be concentrated into density in 60~65 DEG C³；

In the preparation of red paeonia extract, the concentration is 1.15~1.18g/cm to be concentrated into density in 60~65 DEG C³；Institute State alcohol precipitation standing are as follows: 95% ethyl alcohol of 3-5 times of weight of enriched product is added, stirs 20~50min, stands 8~16h.

In some specific embodiments of the invention, the vacuum drying vacuum degree is -0.075~-0.085Mpa, Temperature is 60 DEG C, moisture content < 9%.

The present invention also provides compositions made from the composition or the preparation method in the medicine for preparing smoothing wrinkle Application in object and/or cosmetics.

The present invention also provides drug or cosmetics, comprising combining made from the composition or the preparation method Object and acceptable auxiliary material.

In some specific embodiments of the invention, the dosage form of the drug is gelling agent, injection, patch, ointment Deng.

The present invention provides contain dark plum in a kind of pharmaceutical composition for smoothing wrinkle, Chinese gall, radix paeoniae rubra, citric acid, do not have Five kinds of raw materials of gallate-based.We use the theory of traditional Chinese medical science of monarch, and dark plum is monarch, and Chinese gall is minister, and two medicines have cooperateed with convergence Effect, radix paeoniae rubra stagnation resolvation using corrigent are aided with citric acid, gallic acid, and pharmaceutically or cosmetically field is being added in five kinds of raw material rational proportions In after common auxiliary material or auxiliary element, can be prepared into gelling agent, injection, patch, ointment etc..The pharmacological property of former Chinese medicine is kept to make With and compatibility relationship, it is on probation through crowd, have and promote skin cell metabolism, improve skin natural moisture preserving ability, tool is used for a long time The advantages that being reduced or eliminate small fine wrinkles, irritation, safe without toxic side effect.

Specific embodiment

The invention discloses a kind of pharmaceutical composition and its application for smoothing wrinkle, those skilled in the art can use for reference this Literary content, is suitably modified realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are to art technology It is it will be apparent that they are considered as being included in the present invention for personnel.Method and application of the invention has passed through preferably Embodiment is described, related personnel obviously can not depart from the content of present invention, in spirit and scope to side as described herein Method and application are modified or appropriate changes and combinations, carry out implementation and application the technology of the present invention.

A kind of pharmaceutical composition for smoothing wrinkle, which is characterized in that be made of following components in parts by weight: dark plum 30~50 parts by weight of extract, 10~30 parts by weight of nutgall extractive, 10~30 parts by weight of red paeonia extract, citric acid 5~ 20 parts by weight, 5~15 parts by weight of gallic acid.

A kind of pharmaceutical composition for smoothing wrinkle, which is characterized in that consist of the following parts by weight: dark plum 35~45 parts by weight of extract, 15~25 parts by weight of nutgall extractive, 12~25 parts by weight of red paeonia extract, citric acid 8~ 15 parts by weight, 8~12 parts by weight of gallic acid.

In other embodiments of invention, the smoked plum extractive is made by following steps: dark plum Chinese medicine is taken, It crushes, crosses 60 meshes, it is 80~90% that 25~35 times of (25~35mL ethyl alcohol is added in mass volume ratio, i.e. 1g medicinal material) concentration, which are added, Ethyl alcohol, at 60~80 DEG C of temperature, every time extract 2~4 hours, filtering, recycle ethyl alcohol, filtrate be concentrated (60~65 DEG C) extremely Density is 1.0~1.5g/cm³, medicinal extract is obtained, is dried in vacuo, smoked plum extractive is obtained；

The nutgall extractive is made by following steps: being taken Chinese gall medicinal material, is ground into fine powder, its weight is added The purified water of 10~20 times (10~20ml water is added in mass volume ratio, i.e. 1g medicinal material), at 100 DEG C, after extracting 1~3 hour, into Row filtering, is extracted 2~4 times, merging filtrate altogether, is stood for 24 hours, and it is 1.0~1.1g/ that (60~65 DEG C) to relative density, which is concentrated, in filtrate cm³, medicinal extract obtains in (60 DEG C) dryings (moisture content < 9%) in vacuum (vacuum degree: -0.075~-0.085Mpa) drying box Nutgall extractive；

The red paeonia extract is made by following steps: radix paeoniae rubra pharmaceutical decocting piece taken, the Ultramicro-powder of 1500 mesh is crushed to, The acidity that the PH=2 of 6~10 times of its weight (6~10ml acidic aqueous solution is added in mass volume ratio, i.e. 1g medicinal material) is added is water-soluble Liquid extracts 1~2 hour, and filtering is extracted 2~4 times altogether, and merging filtrate is concentrated into 1.15~1.18g/cm of density³, it is added 3~5 95% ethyl alcohol alcohol precipitation of times weight stirs 20~50min, stands 8~16h, precipitates vacuum dried, sieving, obtains radix paeoniae rubra extraction Object.

In some embodiments of the invention, the acidic aqueous solution is the mixing of one or both of hydrochloric acid, phosphoric acid Object.

A kind of pharmaceutical composition for smoothing wrinkle, which is characterized in that the product type is gelling agent, patch Agent, ointment etc..

The product, which has, promotes skin cell metabolism, improves skin natural moisture preserving ability, reduces or eliminates tiny wrinkle The characteristics of line.

Contain dark plum, Chinese gall, radix paeoniae rubra, citric acid, galla turcica in a kind of pharmaceutical composition for smoothing wrinkle of the invention Sour five kinds of raw materials.We use the theory of traditional Chinese medical science of monarch, and dark plum is monarch, and Chinese gall is minister, and two medicines have cooperateed with astriction, Radix paeoniae rubra stagnation resolvation using corrigent, is aided with citric acid, gallic acid, and five kinds of raw material rational proportions are normal in pharmaceutically or cosmetically field is added After auxiliary material or auxiliary element, gelling agent, injection, patch, ointment etc. can be prepared into.Keep former Chinese medicine pharmacological property effect and Compatibility relationship, it is on probation through crowd, have and promote skin cell metabolism, improve skin natural moisture preserving ability, long-time service, which has, to be subtracted The advantages that less or eliminating small fine wrinkles, irritation, safe without toxic side effect.

It can be purchased by market provided by the present invention for agents useful for same in the pharmaceutical composition and its application of smoothing wrinkle and raw material .

Below with reference to embodiment, the present invention is further explained: