阅读说明：本技术 一种低温纳米级高剪切乳化装置 (A kind of low-temperature nano grade high-shear emulsifying device ) 是由 李建彬 黎鹏 唐水荣 杜庆华 蔡军民 于 2019-10-08 设计创作，主要内容包括：本发明涉及一种低温纳米级高剪切乳化装置,包括罐体,罐体内设有剪切乳化单元,罐体的顶部设有与剪切乳化单元连接的驱动单元,所述剪切乳化单元包括设置在罐体内的剪切乳化转动套,剪切乳化转动套包括剪切头齿形结构部以及物料进入部,剪切头齿形结构部包括设置在剪切乳化转动套端部的多个环形排布的剪切孔,剪切孔保持罐体的内腔与剪切乳化转动套的内腔连通,同时,物料进入部包括设置在剪切乳化转动套周面上和剪切头下方的多个物料进入口,物料进入口保持剪切乳化转动套的内腔和罐体的内腔连通,罐体内的物料从物料进入口进入剪切乳化转动套内被剪切孔剪切后,从剪切乳化的剪切孔向外排出,极大提高了水相和油相的混合效率。(The present invention relates to a kind of low-temperature nano grade high-shear emulsifying devices, including tank body, emulsification pretreatment unit is equipped in tank body, the top of tank body is equipped with the driving unit connecting with emulsification pretreatment unit, the emulsification pretreatment unit includes being arranged in the intracorporal emulsification pretreatment turning set of tank, emulsification pretreatment turning set includes cutting head tooth-shape structure portion and material entrance, cutting head tooth-shape structure portion includes the shearing perforation that multiple annular arrangements of emulsification pretreatment turning set end are arranged in, shearing perforation keeps the inner cavity of tank body to be connected to the inner cavity of emulsification pretreatment turning set, simultaneously, material entrance includes being arranged on emulsification pretreatment turning set circumferential surface and multiple material inlet ports below cutting head, material inlet port keeps the inner cavity of emulsification pretreatment turning set to be connected to the inner cavity of tank body, the intracorporal material of tank enters in emulsification pretreatment turning set from material inlet port to be sheared It after the shearing of hole, is discharged from the shearing perforation of emulsification pretreatment, greatly improves the mixing efficiency of water phase and oily phase.)

1. a kind of low-temperature nano grade high-shear emulsifying device, including tank body, tank body is interior to be equipped with emulsification pretreatment unit, the top of tank body Equipped with the driving unit being connect with emulsification pretreatment unit, which is characterized in that the emulsification pretreatment unit includes being arranged in tank body Emulsification pretreatment turning set, emulsification pretreatment turning set include cutting head tooth-shape structure portion and be located at cutting head tooth-shape structure portion one The material entrance of side, the open-ended and inner hollow of the emulsification pretreatment turning set, cutting head tooth-shape structure portion packet The shearing perforation that multiple annular arrangements of emulsification pretreatment turning set end are set is included, the hole wall of shearing perforation has shearing knife edge, cuts Cut hole keeps the inner cavity of tank body to be connected to the inner cavity of emulsification pretreatment turning set；

The material entrance includes the multiple material inlet ports being arranged on emulsification pretreatment turning set circumferential surface, and material inlet port is protected The inner cavity for holding emulsification pretreatment turning set is connected to the inner cavity of tank body.

2. a kind of low-temperature nano grade high-shear emulsifying device according to claim 1, which is characterized in that the driving unit Including the rotation axis that the driving motor of top of the tank is arranged in and connect with driving motor, the end of rotation axis extend into tank body Interior to be fixedly connected with emulsification pretreatment turning set, rotation axis is fixedly connected by reinforcing rib with the tail portion of emulsification pretreatment turning set, is turned The end of moving axis is fixedly connected by multiple stiffening plates with the inner wall of emulsification pretreatment turning set.

3. a kind of low-temperature nano grade high-shear emulsifying device according to claim 2, which is characterized in that rotation axis and shearing It emulsifies turning set formation integral structure or rotation axis and emulsification pretreatment turning set is integrally formed.

4. a kind of low-temperature nano grade high-shear emulsifying device according to claim 1 or 2, which is characterized in that the shearing Hole is in bar shaped, and the two sides of shearing perforation are equipped with stiffening ring.

5. a kind of low-temperature nano grade high-shear emulsifying device according to claim 3, which is characterized in that the top of the tank body Portion has sealing cover, and the side of sealing cover and tank body are hinged, and the other side is connect by retention mechanism with tank body, driving motor installation On sealing cover.

6. a kind of low-temperature nano grade high-shear emulsifying device according to claim 4, which is characterized in that the retention mechanism Fixing seat including tank body side is arranged in, the flange on the outside of sealing cover, flange are connect with fixing seat by screw rod.

7. a kind of low-temperature nano grade high-shear emulsifying device according to claim 4, which is characterized in that on the sealing cover Oily phase supply pipe is installed, oily phase supply pipe is extend into the inner cavity of tank body, and the end of oily phase supply pipe has bend pipe, and bend pipe is opened Mouthful towards the emulsification pretreatment unit.

8. a kind of low-temperature nano grade high-shear emulsifying device according to claim 6, which is characterized in that the bottom of the tank body Portion has stabilizer blade, and the side of tank body is with lifting plate.

Technical field

Realize that the height of nanoscale emulsifying effectiveness is cut the present invention relates to mechanized clipping equipment, under specially a kind of low temperature high shear Emulsifier unit is cut, is used when can be used in emulsion mass production.

Background technique

Emulsion refers to immiscible two-phase liquid, is formed wherein a phase is scattered in another phase liquid with droplet state Non-homogeneous dispersion liquid preparation.Form drop is mutually known as dispersed phase, interior phase or discontinuous phase, and another phase liquid is then known as Decentralized medium, foreign minister or continuous phase.

Emulsion is small in size due to emulsifying in small-scale experiment, is generally emulsified using laboratory's high-shear device.Shearing Rate may be up to 10000~40000RPM.Quickly the emulsification of lab scale sample can be finished in a short time.But after amplification production, Since emulsification volume increases, emulsified using the shear in laboratory, emulsification times can lengthen significantly, or even due to volume It is excessive, cause emulsification uneven, qualified product can not be produced, meanwhile, long-time high speed shear, under the high temperature conditions, meeting The impurity of emulsion is caused to greatly increase.

Existing emulsification pretreatment equipment is mostly stirring-type, and promising coaxial multiple-blade, some is multiaxis multiple-blade, blade Design is also five multifarious, is provided to increase blade to the mixing surface of material, has derived numerous machinery on this basis Stirring structure design, such as:

CN201620115353.0 is socketed with guide sleeve, vertical peace in the middle part of the lower end surface of the fixed plate on the side wall of fixed plate Equipped with material feeding guide sleeve, hollow out is disposed on the side wall of the material feeding guide sleeve, the shaft that the motor lower end is stretched out passes through fixed plate It extend into material feeding guide sleeve and is connected with shear-blade, the upper surface of the fixed plate has been evenly arranged several around machine shaft A through-hole.

CN201720933449.2, retainer plate are provided centrally with rotary shaft, and are fixed with first on the upside of rotary shaft and turn over Expect impeller, is fixed with rotary shaft on the inside of the second stirring impeller, shearing stator is installed on the outside of the graphite bushing, and It shears and is provided with acorn nut on the downside of the outer end of stator, impeller of rotor, and impeller of rotor are installed on the inside of the shearing stator Outer end be fixed with rotor blade, be connected with sheared edge on the outside of the rotor blade.

CN201721150797.9 is provided with shear knife group on main shaft, and the main shaft lower end is connected with sleeve assembly, Sleeve assembly is connected with supporting plate by fixed strut, and rabbling mechanism is additionally provided on the main shaft, and the rabbling mechanism includes fixing Gear one on main shaft is set, be respectively equipped on two fixed struts with one meshed gears two of gear, the gear two with Fixed strut is rotatablely connected, and is respectively equipped with the stirring rod being vertically arranged, the blender on the upper and lower surfaces of the gear two There are two structure is set, the shear knife group is located between two rabbling mechanisms.

Since emulsion has the dispersion degree of drop very big, drug absorption and drug effect are played quickly, the spies such as bioavilability height Point, in recent years in field of medicine preparations extensive utilization.In view of the particularity of pharmaceutical preparation, common emulsion production method is grease Phase high-shear emulsifying, at present the country (containing external import brand, such as Fu Luke) high-shear device under the conditions of 60~70 DEG C Shear effect is best, but many drugs are more unstable at 60 DEG C or more, is easy to happen degradation, traditional emulsification pretreatment device When the revolving speed of cutting head rotor is excessive, it is easy to appear eccentric motion, shear effect is bad.Moreover, because emulsification is oily phase and water The mixing of phase, oily phase density is lighter, conventional shear, and material is to suck from below, in cutting head oil at a distance of from compared with When big, oil is mutually difficult to be drawn into shear to be emulsified.Although the prior art includes setting for three kinds of technologies of above-mentioned reference In respect of certain reference roles, but when still can't resolve pharmaceutical preparation emulsification there are the problem of, especially versatility problem.

The present invention is in view of the above problems, invented a set of low temperature high shear nanoscale emulsification that can be applied in mass production High-shear emulsifying device realizes product high speed shear nanoscale mainly under 55 DEG C of (or under lower temperature) cryogenic conditions Emulsification.

Summary of the invention

The purpose of the present invention is to solve defects of the existing technology, provide a kind of low-temperature nano grade high-shear emulsifying Device.

To achieve the goals above, The technical solution adopted by the invention is as follows:

A kind of low-temperature nano grade high-shear emulsifying device, including tank body, tank body is interior to be equipped with emulsification pretreatment unit, sets at the top of tank body There is the driving unit connecting with emulsification pretreatment unit, the emulsification pretreatment unit includes setting in the intracorporal emulsification pretreatment rotation of tank Set, emulsification pretreatment turning set include that cutting head tooth-shape structure portion and the material positioned at cutting head tooth-shape structure portion side enter Portion, the open-ended and inner hollow of the emulsification pretreatment turning set, cutting head tooth-shape structure portion include that setting is being sheared The shearing perforation of multiple annular arrangements of turning set end is emulsified, the hole wall of shearing perforation has shearing knife edge, and shearing perforation keeps tank body Inner cavity be connected to the inner cavity of emulsification pretreatment turning set；

The material entrance includes the multiple material inlet ports being arranged on emulsification pretreatment turning set circumferential surface, and material inlet port is protected The inner cavity for holding emulsification pretreatment turning set is connected to the inner cavity of tank body.

Further, the driving unit includes turn that the driving motor of top of the tank is arranged in and connect with driving motor Moving axis, the end of rotation axis extend into tank body and are fixedly connected with emulsification pretreatment turning set, and rotation axis passes through reinforcing rib and shearing The tail portion of emulsification turning set is fixedly connected, and the end of rotation axis is fixed by multiple stiffening plates and the inner wall of emulsification pretreatment turning set Connection.

Further, rotation axis forms integral structure or rotation axis with emulsification pretreatment turning set and emulsification pretreatment turning set is whole It is body formed.

Further, the shearing perforation is in bar shaped, and the two sides of shearing perforation are equipped with stiffening ring.

Further, the top of the tank body has sealing cover, and the side of sealing cover and tank body are hinged, and the other side passes through fastening Mechanism is connect with tank body, and driving motor is mounted on sealing cover.

Further, the retention mechanism includes the fixing seat that tank body side is arranged in, the flange on the outside of sealing cover, method Orchid is connect with fixing seat by screw rod.

Further, oily phase supply pipe is installed, oily phase supply pipe is extend into the inner cavity of tank body, and oil mutually supplies on the sealing cover A bend pipe is had to the end of pipe, and the opening of bend pipe is towards the emulsification pretreatment unit.

Further, the bottom of the tank body has stabilizer blade, and the side of tank body is with lifting plate.

The invention has the benefit that shear rate: when the revolving speed of common cutting head rotor is excessive, being easy to appear eccentric fortune It is dynamic, the friction of the fixed block between stator can be sharply increased, therefore shear rate cannot be too high, typically up to can only achieve 3000rpm or so, this shear is using rotation axis and the integrated design of emulsification pretreatment turning set, it is ensured that emulsification pretreatment turning set When running at high speed, eccentric motion will not be led to because of revolving speed is excessive, meanwhile, also avoid revolving speed is excessive rotation axis is caused to generate change Shape, this connection type can meet the normal operation of the speed shear of motor 6000RPM by test；

Cutting head tooth-shape structure portion of the invention includes the shearing that multiple annular arrangements of emulsification pretreatment turning set end are arranged in Hole, the hole wall of shearing perforation have shearing knife edge, and shearing perforation keeps the inner cavity of tank body to be connected to the inner cavity of emulsification pretreatment turning set, cuts Cut hole is in bar shaped, and the two sides of shearing perforation are equipped with stiffening ring, can avoid that emulsification pretreatment turning set is caused to deform when ultra high shear, together When, material entrance includes being arranged on emulsification pretreatment turning set circumferential surface and multiple material inlet ports below cutting head, material Inlet port keeps the inner cavity of emulsification pretreatment turning set to be connected to the inner cavity of tank body, and the intracorporal material of tank enters from material inlet port to be cut It cuts after being sheared hole shearing in emulsification turning set, is discharged from the shearing perforation of emulsification pretreatment, greatly improve water phase and oily phase Mixing efficiency.

The change of the present invention through the above structure, can be such that shearing rotating speed is greatly improved, meanwhile, pass through optimizing shear head knot Structure, it is ensured that the area of shearing greatly increases, and improves shear efficiency, makes shear that can also reach general under conditions of low temperature Shear effect of the logical high-shear device in 60~70 DEG C of conditions.

In addition, installing oily phase supply pipe on sealing cover, oily phase supply pipe is extend into the inner cavity of tank body, oily phase supply pipe End has bend pipe, and the opening of bend pipe is towards the emulsification pretreatment unit, and oily phase supply pipe is by bend pipe by oily mutually towards cutting head Tooth-shape structure portion guiding, by shearing perforation in time to grease phase high speed shearing emulsification, further increases shear efficiency.

Detailed description of the invention

Fig. 1 is the structural diagram of the present invention；

Fig. 2 is the structural schematic diagram of emulsification pretreatment turning set of the present invention；

Fig. 3 is the front schematic view of emulsification pretreatment turning set of the present invention；

Fig. 4 is the connection schematic diagram of emulsification pretreatment turning set and rotation axis of the present invention；

Fig. 5 is the connection schematic diagram inside emulsification pretreatment turning set of the present invention with rotation axis.

Specific embodiment

As shown in Figures 1 to 5, a kind of low-temperature nano grade high-shear emulsifying device, including tank body 1, tank body 1 is interior to be equipped with shearing Emulsification unit, the top of tank body 1 are equipped with the driving unit connecting with emulsification pretreatment unit, and emulsification pretreatment unit includes being arranged in tank Emulsification pretreatment turning set 2 in body 1, emulsification pretreatment turning set 2 is including cutting head tooth-shape structure portion and is located at cutting head tooth form The material entrance of structural portion side, the open-ended and inner hollow of emulsification pretreatment turning set 2, cutting head tooth-shape structure portion packet The shearing perforation 3 that multiple annular arrangements of 2 end of emulsification pretreatment turning set are set is included, the hole wall of shearing perforation 3 has shearing knife edge, Shearing perforation 3 keeps the inner cavity of tank body 1 to be connected to the inner cavity of emulsification pretreatment turning set 2；

Material entrance includes the multiple material inlet ports 4 being arranged on 2 circumferential surface of emulsification pretreatment turning set, and material inlet port 4 is protected The inner cavity for holding emulsification pretreatment turning set 2 is connected to the inner cavity of tank body 1.

Further, driving unit includes turn that the driving motor 5 at 1 top of tank body is arranged in and connect with driving motor 5 Moving axis 6, the end of rotation axis 6 extend into tank body 1 and connect with emulsification pretreatment turning set 2, and rotation axis 6 passes through reinforcing rib 7 and cuts The tail portion for cutting emulsification turning set 2 is fixedly connected, and the end of rotation axis 6 is interior by multiple stiffening plates 8 and emulsification pretreatment turning set 2 Wall is fixedly connected, and rotation axis 6 and emulsification pretreatment turning set 2 form integral structure.It is preferred that rotation axis 6 and emulsification pretreatment turning set 2 is integrally formed, such as uses cast member.

In addition, shearing perforation 3 is in bar shaped, the two sides of shearing perforation 3 are equipped with stiffening ring 9.

Further, the top of tank body 1 has sealing cover 10, and the side of sealing cover 10 and tank body 1 are hinged, and the other side passes through tight Gu mechanism is connect with tank body 1, driving motor 5 is mounted on sealing cover 10.Retention mechanism includes the fixation that 1 side of tank body is arranged in Seat 11, the flange 12 positioned at 10 outside of sealing cover, flange 12 are connect with fixing seat 11 by screw rod 13.

Further, oily phase supply pipe 14 is installed, oily phase supply pipe 14 is extend into the inner cavity of tank body 1, oil on sealing cover 10 The end of phase supply pipe 14 has a bend pipe 15, and the opening of bend pipe 15 is towards the emulsification pretreatment unit.

In the present invention, the bottom of tank body 1 has stabilizer blade 16, and tank body 1 has collet 17, and collet 17 is equipped with heat-exchange device, The fluid temperature of shear history is controlled by the cooling or heating function of collet.

Shear rate: when the revolving speed of common cutting head rotor is excessive, it is easy to appear eccentric motion, meeting sharply increases and stator Between fixed block friction, therefore shear rate cannot be too high, typically up to can only achieve 3000rpm or so, this shear Using rotation axis 6 and 2 integrated design of emulsification pretreatment turning set, it is ensured that emulsification pretreatment turning set 2 is when running at high speed, Bu Huiyin Lead to eccentric motion for revolving speed is excessive, meanwhile, also avoid revolving speed is excessive rotation axis 6 is caused to be deformed, this connection type is passed through Test, can meet the normal operation of the speed shear of motor 6000RPM；

Cutting head tooth-shape structure portion of the invention includes the shearing that multiple annular arrangements of 2 end of emulsification pretreatment turning set are arranged in Hole 3, the hole wall of shearing perforation 3 have shearing knife edge, and shearing perforation 3 keeps the inner cavity of tank body 1 and the inner cavity of emulsification pretreatment turning set 2 to connect Logical, shearing perforation 3 is in bar shaped, and the two sides of shearing perforation 3 are equipped with stiffening ring 9, can avoid causing emulsification pretreatment to rotate when ultra high shear 2 deformation of set, meanwhile, it includes the feeding port that 1 top of oily phase supply pipe 14 and tank body is arranged in that material, which enters tank interior, and material is thrown After entering tank inner body 1, when shearing, material is entered in shear by the lower section of material inlet port 4 and strong circle 9, after emulsification pretreatment, It is discharged by shearing perforation 3.Greatly improve the mixing efficiency of water phase and oily phase.

The change of the present invention through the above structure, can be such that shearing rotating speed is greatly improved, meanwhile, pass through optimizing shear head knot Structure, it is ensured that the area of shearing greatly increases, and improves shear efficiency, makes shear that can also reach general under conditions of low temperature Shear effect of the logical high-shear device in 60~70 DEG C of conditions.

In addition, installing oily phase supply pipe 14 on sealing cover 10, oily phase supply pipe 14 is extend into the inner cavity of tank body 1, oily phase The end of supply pipe 14 has bend pipe 15, and towards the emulsification pretreatment unit, oily phase supply pipe 14 passes through curved the opening of bend pipe 15 Pipe 15 is mutually oriented to oily towards cutting head tooth-shape structure portion, by shearing perforation 3 in time to grease phase high speed shearing emulsification, is further mentioned High shear efficiency.

The following are common shears and shear actual test data of the present invention to compare:

By the comparison of the above test data as can be seen that shear of the present invention is improved by changing emulsifier unit turning set 2 The intensity of turning set greatly improves turning for shear so that turning set be made to be able to bear higher shearing rotating speed limitation Speed, meanwhile, using special feeding manner and special cutting head tooth-shape structure, the effect of emulsification pretreatment is greatly improved, So as to meet under 55 DEG C of (or under lower temperature) cryogenic conditions, the emulsification of product high speed shear nanoscale is realized.

The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its Equivalent defines.