阅读说明：本技术 一种胸腔填充心脏托杯及其制备方法 (A kind of thoracic cavity filling heart hypanthium and preparation method thereof ) 是由 谭周建 于 2019-09-27 设计创作，主要内容包括：本发明公开了一种胸腔填充心脏托杯及其制备方法,心脏托杯具有船形结构；船形结构由碳纤维复合材料层构成,或由碳纤维复合材料层及其表面的高分子防护层构成,或由碳纤维织物层及其表面的高分子防护层构成。该心脏托杯由碳纤维复合材料构成,具有质量轻、比强度高、组织相容性好、使用方便,稳定性好等优点。(The invention discloses a kind of thoracic cavity filling heart hypanthiums and preparation method thereof, and heart hypanthium has ship shape structure；Ship shape structure is made of carbon fibre composite layer, or is made of the macromolecule protective layer on carbon fibre composite layer and its surface, or is made of the macromolecule protective layer on carbon fiber fabric plies and its surface.The heart hypanthium is made of carbon fibre composite, has many advantages, such as that light weight, specific strength are high, histocompatbility is good, easy to use, stability is good.)

1. heart hypanthium is filled in a kind of thoracic cavity, it is characterised in that: have ship shape structure；The ship shape structure is by carbon fiber composite The bed of material is constituted, or is made of the macromolecule protective layer on carbon fibre composite layer and its surface, or by carbon fiber fabric plies and its The macromolecule protective layer on surface is constituted.

2. heart hypanthium is filled in a kind of thoracic cavity according to claim 1, it is characterised in that: the carbon fibre composite layer It is made of the matrix carbon and/or silicon carbide filled in continuous carbon fibre fabric and carbon fiber；The carbon fiber fabric plies are by continuous Carbon fibre fabric is constituted.

3. heart hypanthium is filled in a kind of thoracic cavity according to claim 2, it is characterised in that: the continuous carbon fibre fabric packet Include at least one layer of looped fabric, woven cloth or woven fabric.

4. heart hypanthium is filled in a kind of thoracic cavity according to claim 2 or 3, it is characterised in that: the continuous carbon fibre is knitted Object is woven to obtain by carbon fiber bundle, and the fiber number of carbon fiber bundle is 1k, 3k, 6k, 12k or 24k.

5. heart hypanthium is filled in a kind of thoracic cavity according to claim 1, it is characterised in that: the macromolecule protective layer is At least one of PEEK, PTFE, PE, PET, PU.

6. heart hypanthium is filled in a kind of thoracic cavity according to claim 1, it is characterised in that: the center of the ship shape structure Domain with a thickness of 0.5mm~5mm, macromolecule protective layer with a thickness of 0.1mm~2mm.

7. heart hypanthium is filled in a kind of thoracic cavity according to claim 1, it is characterised in that: the center of the ship shape structure Domain is the cambered surface area contacted with heart, and neighboring area is the Yan Mianqu contacted with the wall of the chest, described to be equipped with reinforcing rib along face district center And fixation hole, aperture are 1mm~4mm, spacing is 5mm~30mm.

8. heart hypanthium is filled in a kind of thoracic cavity according to claim 7, it is characterised in that: the reinforcing rib be carbon fiber or The braid over braid of carbon fiber rope.

9. heart hypanthium is filled in a kind of thoracic cavity according to claim 8, it is characterised in that: the reinforcing rib be by 3 beams with Carbon fiber tape made of upper carbon fiber braiding, or the carbon fiber rope obtained by single beam or multi-beam carbon-fiber twisting braiding；Wherein, The fiber number of single beam carbon fiber is 1k, 3k, 6k, 12k or 24k.

10. a kind of preparation method of thoracic cavity filling heart hypanthium according to any one of claims 1 to 9, it is characterised in that: including Following steps:

1) by after one layer of carbon cloth or multi-storey up-down and translation superposition, ship shape structure is pressed by mold auxiliary, obtains carbon fiber Tie up green body；

2) after by chemical vapor infiltration and/or dipping-cracking process to carbon fiber blank density matrix carbon and/or silicon carbide, Machining to get；

Alternatively, after preparing polymeric coating layer on carbon fiber blank surface by electrostatic spraying, machining to get；

Alternatively, first passing through chemical vapor infiltration and/or dipping-cracking process to carbon fiber blank density matrix carbon and/or carbonization After silicon, then after preparing polymeric coating layer on carbon fiber blank surface by electrostatic spraying, machining to get.

Technical field

The present invention relates to a kind of thoracic cavity packing material, in particular to heart is filled in a kind of thoracic cavity by carbon material fabric plastotype Hypanthium further relates to preparation method, belongs to biomedical materials field.

Background technique

The row total pneumonectomy due to central type carcinoma of lung, lung damage, tracheal neoplasm etc. causes thoracic cavity large area empty It sets, other organs are subjected to displacement to vacant area, and blood vessel, tracheae is caused to deform, and cause a series of sequelae, or even jeopardize life Life.Usually consider to be filled, to maintain the concertedness and stability of thoracic organ, ensures the function of normal tissue.Both at home and abroad Have a report filled using silicon rubber or normal saline bag, but because silicon rubber or normal saline bag itself without it is stable shaped, Poor rigidity, filling effect are undesirable.Existing artificial material such as polytetrafluoroethylene (PTFE), methacrylic resin, metal, organic glass A series of problems, such as there is also the mechanical compatibilities that intensity is insufficient or intensity is excessive, biocompatibility with the materials such as steel wire.

Summary of the invention

In order to solve deficiency existing for existing thoracic cavity packing material, the purpose of the invention is to provide one kind by carbon fiber What composite material was constituted fills the heart with light weight, the thoracic cavity that specific strength is high, histocompatbility is good, easy to use, stability is good Dirty hypanthium.

Second object of the present invention is to be to provide that a kind of step is simple, raw material is easy to get and prepares thoracic cavity filling heart hypanthium Method.

In order to achieve the above technical purposes, the present invention provides a kind of thoracic cavities to fill heart hypanthium, with ship shape structure； The ship shape structure is made of carbon fibre composite layer, or by carbon fibre composite layer and its macromolecule protective layer on surface It constitutes, or is made of the macromolecule protective layer on carbon fiber fabric plies and its surface.

Preferred scheme, the carbon fibre composite layer is by the matrix carbon filled in continuous carbon fibre fabric and carbon fiber And/or silicon carbide is constituted.

Preferred scheme, the carbon fibre composite layer are made of continuous carbon fibre fabric.

Preferred scheme, described matrix carbon such as pyrolytic carbon, resin carbon, bitumencarb etc..

Preferred scheme, the carbon fibre fabric include at least one layer of looped fabric, woven cloth or woven fabric.Looped fabric, such as Warp knitting cloth, weft-knitted fabric；Woven cloth, such as two-dimentional cloth, three-dimensional cloth, stereo weaving cloth；Woven fabric, such as plain cloth, twill, satin weave Cloth.

Preferred scheme, the carbon fibre fabric are woven to obtain by carbon fiber bundle, the fiber number of carbon fiber bundle be 1k, 3k, 6k, 12k or 24k (1k indicates 1,000).

Preferred scheme, the macromolecule protective layer are PEEK (polyether-ether-ketone), PTFE (polytetrafluoroethylene (PTFE)), PE (poly- second Alkene), PET (polyester), at least one of PU (polyurethane).Macromolecule protective coating can effective protection internal layer carbon-based particles it is de- It falls, and avoids contacting with the hard of heart.

Preferred scheme, the central area of the ship shape structure is with a thickness of 0.5mm~5mm, the thickness of macromolecule protective layer For 0.1mm~2mm.

Preferred scheme, the central area of the ship shape structure are the cambered surface area contacted with heart, and neighboring area is and chest Wall contact Yan Mianqu, it is described along face district center be equipped with reinforcing rib and fixation hole, aperture be 1mm~4mm, spacing be 5mm~ 30mm.Heart hypanthium is designed to that ship shape structure, stable structure can effectively support heart, and can maintain the steady of internal organs in thoracic cavity It is fixed, and left and right thickness is small, can reduce operation wound face.

Preferred scheme, the reinforcing rib are the braid over braid of carbon fiber braid over braid or carbon fiber rope.

More preferably scheme, the reinforcing rib are the carbon fiber tapes as made of the above carbon fiber braiding of 3 beams, or by single beam Or the carbon fiber rope that multi-beam carbon-fiber twisting braiding obtains；Wherein, the fiber number of single beam carbon fiber be 1k, 3k, 6k, 12k or 24k.Reinforcing rib can be improved the stability of ship type structure, improve its mechanical property.

The present invention provides a kind of preparation methods of thoracic cavity filling heart hypanthium comprising following steps:

1) carbon cloth is cut on demand in flakes；

2) by after one layer of carbon cloth or multi-storey up-down and translation (looped fabric, woven cloth or woven fabric) superposition, pass through mold Auxiliary is pressed into ship shape structure, while reinforcing rib further can be arranged along face area in ship shape structure, obtains carbon fiber blank；

3) by chemical vapor infiltration and/or dipping-cracking process to carbon fiber blank density matrix carbon and/or silicon carbide Afterwards, machine to get；

Alternatively, after preparing polymeric coating layer on carbon fiber blank surface by electrostatic spraying, machining to get；

Alternatively, first pass through chemical vapor infiltration and/or dipping-cracking process to carbon fiber blank density matrix carbon and/or After silicon carbide, then after preparing polymeric coating layer on carbon fiber blank surface by electrostatic spraying, machining to get.

Carbon fibre fabric of the invention is looped fabric, such as warp knitting cloth, weft-knitted fabric, surface density 30g/m²~500g/m²； Woven cloth, such as two-dimentional cloth, three-dimensional cloth etc., surface density 150g/m²~1200g/m²；Woven fabric, such as plain cloth, twill, satin weave Cloth, surface density 120g/m²~1000g/m²。

Chemical vapor infiltration of the invention generates matrix carbon technique: carbon fiber precast body being put into vacuum drying oven, 850 DEG C~1300 DEG C at a temperature of, (natural gas, methane or propylene etc., nitrogen or hydrogen are diluent gas, carbon source for the carbon containing gas source that is passed through The flow-rate ratio of gas and diluent gas is 1:0~2) after cracking, chemical vapor infiltration is small by 10 in carbon fiber blank When~100 hours, it is prepared into carbon fibre composite green body.

Dipping-of the invention is cracked to form matrix carbon technique: carbon fiber precast body passes through resin (furans, phenolic aldehyde and chaff ketone Deng) or pitch (asphalt, coal tar pitch) vacuum pressed dipping, curing process (resin), cracking (resin: 900 DEG C~1050 DEG C, normal pressure；Pitch: 750 DEG C~850 DEG C, 50MPa~200MPa) etc. densification processes.Impregnation pressure be 1.0MPa~ 5.0MPa, dip time are 2 hours~10 hours；Solidification temperature is 160 DEG C~230 DEG C, and curing time is 10 hours~50 small When；Pyrolysis time is 2 hours~20 hours.

Chemical vapor infiltration of the invention generates silicon carbide-based body technology: carbon fiber precast body being put into vacuum drying oven, In At a temperature of 900 DEG C~1300 DEG C, (trichloromethyl silane, hydrogen are carrier gas and diluent gas, trichloromethyl silane to the gas source being passed through Be 1:1~10 with the flow-rate ratio of hydrogen), after cracking, chemical vapor infiltration in carbon fiber blank, by 10 hours~ 100 hours, it is prepared into carbon fibre composite green body.

Dipping-of the invention is cracked to form silicon carbide-based body technology: carbon fiber precast body passes through (the poly- carbon silicon containing silicon precursor Alkane PCS, polymethyl silicane PMS) densification processes such as vacuum pressed dipping, curing process, cracking.Impregnation pressure 1.0MPa~ 5.0MPa, dip time are 2 hours~10 hours；Solidification temperature is 160 DEG C~230 DEG C, and curing time is 10 hours~50 small When；Cracking temperature is 800 DEG C~1150 DEG C, and the time is 2 hours~20 hours；Ceramming temperature is 1200 DEG C~1600 DEG C, when Between be 2 hours~10 hours.

Chemical vapor infiltration of the invention generates silicon carbide-carbon matrix technique: can first generate matrix carbon, regeneration carbonization Silicon perhaps generates carbon and silicon carbide simultaneously or first generates silicon carbide, regenerates matrix carbon.Carbon and silicon carbide are generated simultaneously Technique: carbon base body gas source and trichloromethyl silane are passed through simultaneously, and other conditions are identical as the process conditions of matrix carbon are generated.

Dipping-of the invention is cracked to form silicon carbide-carbon matrix technique, can first dense carbon, then compact silicon carbide, or Dense carbon and silicon carbide simultaneously, or first compact silicon carbide, then dense substrate carbon.The work of dense substrate carbon and silicon carbide simultaneously Skill: it is impregnated simultaneously by resin/pitch and containing silicon precursor, other conditions are identical as the process conditions of dense substrate carbon.

Electrostatic spraying of the invention prepares the technological parameter of polymeric coating layer: 1) polymeric powder granularity is 100 μm~300 μm；2) electrostatic spraying is with a thickness of 0.1mm~2mm；3) solidification temperature is 150 DEG C~420 DEG C.

The mold being related to of the invention can prepare phase according to required shape by existing 3D printing technique Mold is answered, mold materials can be aluminium alloy, carbon material etc..

Processing of the invention includes: that fixation hole is beaten in the area contouring He Yanmian, and wherein fixation hole aperture is 2mm~4mm, Away from for 10mm~40mm.

Carbon fiber and composite body of the invention can also carry out high temperature removal of impurities processing, treatment process condition are as follows: temperature Degree is 1500 DEG C~2300 DEG C, and soaking time is 1 hour~10 hours.

Compared with the prior art, technical solution of the present invention bring advantageous effects:

It is carbon fibre reinforced composite that the present invention, which provides heart hypanthium, has light weight, good biocompatibility, chemistry steady The features such as qualitative good, mechanical property is good；

The present invention provide heart hypanthium by setting macromolecule layer can effective protection internal layer carbon-based particles fall off, avoid with The hard contact of heart；

The present invention provides heart hypanthium and is designed to that ship shape, stable structure can effectively support heart, maintains internal organs in thoracic cavity Stablize, thickness is small, can reduce operation wound face.

Heart hypanthium of the invention can be improved the stability of ship type structure by the way that reinforcing rib is arranged, and can improve its power Performance is learned, heart can be effectively supported, maintains the stabilization of internal organs in thoracic cavity.

Detailed description of the invention

Fig. 1 is sectional view before and after carbon fibre composite heart hypanthium.

Wherein, layer fibre reinforced layer centered on 1,2 be polymeric coating layer, 3 be reinforcing rib, 4 be connecting hole.

Fig. 2 is carbon fibre composite heart hypanthium pictorial diagram prepared by embodiment 1.

Fig. 3 is carbon fibre composite heart hypanthium pictorial diagram prepared by embodiment 2.

Fig. 4 is that the heart hypanthium of embodiment 1 repeatedly recycles the load displacement curve of compression.

Specific embodiment

Following embodiment is intended to further illustrate the content of present invention, rather than limits the claims in the present invention protection scope.