阅读说明：本技术 可变长度血管封堵系统 (Variable-length blood vessel plugging system ) 是由 尼古拉斯·L·塔索尼 霍伊·勒 杰夫瑞·D·约翰逊 于 2018-04-19 设计创作，主要内容包括：血管封堵系统可包括：构造成血管系统内导航的微导管；可滑动地设置在微导管的管腔内部的细长轴,该细长轴具有从细长轴近端延伸至细长轴远端的管腔；可分离地连接到细长轴的多个封堵医疗器械；及可滑动地设置在细长轴和多个封堵医疗器械的每一个的至少一部分的内部的释放线。当把释放线设置在多个封堵医疗器械的每一个的至少一部分的内部时,释放线将多个封堵医疗器械的每一个固定到细长轴的远端。(Blood vessel plugging system can include: be configured to the microtubular to navigate in vascular system；The elongated shaft being slidably disposed on inside the lumen of microtubular, the elongated shaft have the lumen that elongated shaft distal end is extended to from elongated shaft proximal end；It is separably connected to multiple closure medical instruments of elongated shaft；And it is slidably disposed on the cable release of elongated shaft and multiple at least part of inside of each for blocking medical instrument.When multiple each at least part of internal for blocking medical instruments is arranged in cable release, each multiple for blocking medical instruments are fixed to distal ends of elongated shaft by cable release.)

1. a kind of blood vessel plugging system, comprising:

It is configured to the microtubular to navigate in vascular system；

The elongated shaft being slidably disposed on inside the lumen of the microtubular, the elongated shaft have from the close of the elongated shaft End extends to the lumen of the distal end of the elongated shaft；

It is releasably attached to multiple closure medical instruments of the elongated shaft；With

It is slidably disposed in the elongated shaft and at least part of each of the multiple closure medical instrument Cable release；

It is described wherein when the cable release being arranged in the multiple at least part of each for blocking medical instrument Each the multiple for blocking medical instrument is fixed on the distal end of the elongated shaft by cable release.

2. blood vessel plugging system according to claim 1, wherein the multiple closure medical instrument includes: to have to be set as Medical treatment is blocked close to the first closure medical instrument of the proximal end of the distal end of the elongated shaft and with being disposed proximate to described first The second of the proximal end of the distal end of instrument blocks medical instrument.

3. blood vessel plugging system according to claim 2 further includes the distal end and described first that the elongated shaft is arranged in Block the first attachment mechanism between the proximal end of medical instrument；

Wherein first attachment mechanism includes:

With first for being configured to slideably receive the first longitudinal direction lumen of the cable release and have be configured to slidably Receive second of the second longitudinal direction lumen of the cable release in ground；

Wherein described first distal end for being fixedly attached to the elongated shaft, and described second be fixedly attached to it is described First blocks the proximal end of medical instrument；

Wherein described first and second cage structure be at interlocked with one another so that when described first against described second simultaneously And the first longitudinal direction lumen and the second longitudinal direction lumen be when being coaxially aligned, prevent described first with described second it Between axially opposite translation.

4. blood vessel plugging system according to claim 3, wherein described first and second cage structure at joining each other Lock, so that the first longitudinal direction lumen and the second longitudinal direction lumen are coaxially right when described first against described second Standard, and when the cable release and the first longitudinal direction lumen and the second longitudinal direction lumen slidably engage, it prevents described First and it is second described between opposite lateral translation.

5. blood vessel plugging system according to claim 2 further includes that the described first distal end for blocking medical instrument is arranged in The second attachment mechanism between the proximal end of medical instrument is blocked with described second；

Wherein second attachment mechanism includes:

It is configured to slidably with being configured to slideably to receive the third portion of the third longitudinal direction tube chamber of the cable release and having Receive the 4th of the 4th longitudinal direction tube chamber of the cable release in ground；

Wherein the third portion be fixedly attached to it is described first block medical instrument distal end, and described 4th fixedly It is attached to the described second proximal end for blocking medical instrument；

Wherein the third portion and the 4th cage structure be at interlocked with one another so that when the third portion against described 4th simultaneously And the third longitudinal direction tube chamber and the 4th longitudinal direction tube chamber be when being coaxially aligned, prevent the third portion with described 4th it Between axially opposite translation.

6. blood vessel plugging system according to claim 5, wherein the third portion and the 4th cage structure at joining each other Lock, so that the third longitudinal direction tube chamber and the 4th longitudinal direction tube chamber are coaxially right when the third portion is against described 4th Standard, and when the cable release and the third longitudinal direction tube chamber and the 4th longitudinal direction tube chamber slidably engage, it prevents described Third portion and it is 4th described between opposite lateral translation.

7. blood vessel plugging system according to claim 2, wherein the multiple closure medical instrument includes that third blocks doctor Instrument is treated, the third, which blocks medical instrument, has the proximal end for being disposed proximate to the distal end that described second blocks medical instrument.

8. blood vessel plugging system according to claim 7 further includes that the described second distal end for blocking medical instrument is arranged in The third attachment mechanism between the proximal end of medical instrument is blocked with the third；

Wherein the third attachment mechanism includes:

With the 5th for being configured to slideably receive the 5th longitudinal direction tube chamber of the cable release and have be configured to slidably Receive the 6th of the 6th longitudinal direction tube chamber of the cable release in ground；

Wherein described 5th be fixedly attached to it is described second block medical instrument distal end, and described 6th fixedly It is attached to the proximal end that the third blocks medical instrument；

Wherein described 5th and the 6th cage structure be at interlocked with one another so that when described 5th against described 6th simultaneously And the 5th longitudinal direction tube chamber and the 6th longitudinal direction tube chamber be when being coaxially aligned, prevent described 5th with described 6th it Between axially opposite translation.

9. blood vessel plugging system according to claim 8, wherein described 5th and the 6th cage structure at joining each other Lock, so that the 5th longitudinal direction tube chamber and the 6th longitudinal direction tube chamber are coaxially right when described 5th against described 6th Standard, and when the cable release and the 5th longitudinal direction tube chamber and the 6th longitudinal direction tube chamber slidably engage, it prevents described 5th and it is 6th described between opposite lateral translation.

10. blood vessel plugging system according to any one of claim 1 to 9, wherein in the multiple closure medical instrument At least one be coil member, the coil member, which is configured to present when being connected to the elongated shaft, first shape and works as The second shape is presented when separating with the elongated shaft.

11. blood vessel plugging system according to any one of claim 1 to 10, wherein in the multiple closure medical instrument At least one have compared with another in the multiple closure medical instrument different rigidity.

12. blood vessel plugging system according to claim 11, wherein the multiple block distalmost end in medical instrument One has another any rigidity being greater than in the multiple closure medical instrument.

13. blood vessel plugging system according to any one of claim 1 to 12, wherein in the multiple closure medical instrument At least one have compared with another in the multiple closure medical instrument different length.

14. blood vessel plugging system according to claim 1, further include be slidably disposed on it is in the elongated shaft and described The second cable release in multiple at least part of each for blocking medical instrument, wherein second cable release includes spherical shape Top.

15. blood vessel plugging system according to claim 14 further includes being fixedly attached to the multiple closure Medical treatment device The fixing component of the proximal end of each of tool, wherein when both the cable release and second cable release simultaneously extend past When the fixing component, second cable release is prevented to be extracted by the fixing component.

Technical field

The disclosure is directed to medical instrument and for manufacture and/or using medical instrument method.More specifically, the disclosure It is the construction about the blood vessel plugging system with variable-length.

Background technique

The extensive medical treatment in vivo of type for medical application (for example, operation and/or intravascular purposes) is had developed Instrument.These partial instruments include seal wire, conduit, medical appliance conveying system (for example, for bracket, graft, displacement valve Film etc.) etc..These instruments are manufactured using any method in a variety of different manufacturing methods, and can be according to a variety of methods In any method and use.For providing the medical instrument of substitution and for manufacturing and/or replacing using medical instrument For method, there is lasting demands.

Summary of the invention

In a first aspect, blood vessel plugging system can include: be configured to navigate in the microtubular of vascular system；Slideably set The elongated shaft inside the lumen of microtubular is set, which has the lumen that elongated shaft distal end is extended to from elongated shaft proximal end； It is separably connected to multiple closure medical instruments of elongated shaft；And it is slidably disposed on elongated shaft and multiple closure medical treatment The cable release of at least part of inside of each of instrument.When cable release be arranged in it is multiple block medical instruments it is each When a at least part of internal, each multiple for blocking medical instruments are fixed to distal ends of elongated shaft by cable release.

Additionally or alternatively, and in second aspect, multiple closure medical instruments include: have setting with elongated shaft The first of the proximal end of distal end adjacent position blocks medical instrument；Medical instrument distal end adjacent bit is being blocked with first with having to be arranged The second of the proximal end set blocks medical instrument.

Additionally or alternatively, and in the third aspect, blood vessel plugging system may also include the distal end that elongated shaft is arranged in The first attachment mechanism between the proximal end of medical instrument is blocked with first.First attachment mechanism can include: have that be configured to can Slidably receive first of first longitudinal direction lumen of cable release and with being configured to slideably receive the second vertical of cable release To second of lumen, wherein first distal end for being fixedly attached to elongated shaft and second are fixedly attached to the first envelope The proximal end of stifled medical instrument.First and the second cage structure are at interlocked with one another, so that when first against second and first When longitudinal direction tube chamber and second longitudinal direction lumen are coaxially aligned, the translation to axial between first and second is prevented.

Additionally or alternatively, and in fourth aspect, first and the second cage structure are at interlocked with one another, so that when first Against second, first longitudinal direction lumen is coaxially aligned with second longitudinal direction lumen in portion, and cable release and first longitudinal direction lumen and When second longitudinal direction lumen slidably engages, prevent relatively translated laterally between first and second.

Additionally or alternatively, and at the 5th aspect, blood vessel plugging system may also include setting and block medical treatment first The second attachment mechanism between the distal end of instrument and the proximal end of the second closure medical instrument.Second attachment mechanism can include: tool There is the third portion for the third longitudinal direction tube chamber for being configured to slideably receive cable release and have and is configured to slideably receive release The 4th of 4th longitudinal direction tube chamber of line, wherein third portion is fixedly attached to the distal end and the 4th of the first closure medical instrument Portion is fixedly attached to the proximal end of the second closure medical instrument.Third portion and the 4th cage structure are at interlocked with one another, so that working as third Portion prevents between third portion and the 4th against the 4th and when third longitudinal direction tube chamber and the 4th longitudinal direction tube chamber are coaxially aligned Translation to axial.

Additionally or alternatively, and at the 6th aspect, third portion and the 4th cage structure are at interlocked with one another, so that working as third Against the 4th, third longitudinal direction tube chamber is coaxially aligned with the 4th longitudinal direction tube chamber in portion, and cable release and third longitudinal direction tube chamber and When 4th longitudinal direction tube chamber slidably engages, prevent relatively translated laterally between third portion and the 4th.

Additionally or alternatively, and at the 7th aspect, multiple closure medical instruments include that third blocks medical instrument, should Third, which blocks medical instrument, has the proximal end that the distal end adjacent position for blocking medical instrument with second is arranged in.

Additionally or alternatively, and in eighth aspect, which may also include setting and blocks doctor second The distal end and third for the treatment of instrument block the third attachment mechanism between the proximal end of medical instrument.The third attachment mechanism includes: tool There is the 5th of the 5th longitudinal direction tube chamber for being configured to slideably receive cable release and have and is configured to slideably receive release The 6th of 6th longitudinal direction tube chamber of line, wherein the 5th is fixedly attached to the distal end and the 6th of the second closure medical instrument Portion is fixedly attached to the proximal end that third blocks medical instrument.5th and the 6th cage structure are at interlocked with one another, so that when the 5th Portion prevents between the 5th and the 6th against the 6th and when the 5th longitudinal direction tube chamber and the 6th longitudinal direction tube chamber are coaxially aligned Translation to axial.

Additionally or alternatively, and at the 9th aspect, the 5th and the 6th cage structure be at interlocked with one another, so that ought the 5th Against the 6th, the 5th longitudinal direction tube chamber is coaxially aligned with the 6th longitudinal direction tube chamber in portion, and cable release and the 5th longitudinal direction tube chamber and When 6th longitudinal direction tube chamber slidably engages, prevent relatively translated laterally between the 5th and the 6th.

Additionally or alternatively, and at the tenth aspect, at least one of multiple closure medical instruments are volume circles around structure Part (coiled member), the curling component be configured to when being connected to elongated shaft present first shape and when and elongated shaft The second shape is presented when separation.

Additionally or alternatively, and the tenth on the one hand, multiple at least one instrument blocked in medical instrument have The rigidity different from another instrument in multiple closure medical instruments.

Additionally or alternatively, and in the 12nd aspect, multiple instruments for blocking the distalmost end in medical instrument Rigidity with any other instrument being greater than in multiple closure medical instruments.

Additionally or alternatively, and at the 13rd aspect, multiple at least one instrument blocked in medical instrument have The length different from another instrument in multiple closure medical instruments.

Additionally or alternatively, and in fourteenth aspect, blood vessel plugging system may also include the second cable release, this second Cable release is slidably disposed on elongated shaft and multiple at least part of inside of each for blocking medical instrument.

Additionally or alternatively, and at the 15th aspect, the second cable release includes spherical tips.

Additionally or alternatively, and the 16th aspect, blood vessel plugging system may also include be fixedly attached to it is multiple The fixing component for blocking the proximal end of each of medical instrument, wherein when both cable release and the second cable release simultaneously extend warp When crossing the fixing component, the second cable release is prevented to be extracted by the fixing component.

Additionally or alternatively, and in the 17th aspect, blood vessel plugging system can include: be configured to navigate within blood vascular system The microtubular of system；The elongated shaft being slidably disposed on inside the lumen of microtubular, which has prolongs from elongated shaft proximal end Extend to the lumen of elongated shaft distal end；It is separably connected to multiple closure medical instruments of elongated shaft in order；And slideably The cable release of elongated shaft and multiple at least part of inside of each for blocking medical instrument is set, and the cable release is complete Ground extends past at least one of multiple closure medical instruments.When cable release be arranged in it is multiple block medical instruments it is each When a at least part of internal, each multiple for blocking medical instruments are fixed to distal ends of elongated shaft by cable release.

Additionally or alternatively, and at the 18th aspect, cable release is extracted out successively relative to elongated shaft to nearside Discharge each of multiple closure medical instruments of the closure medical instrument from the closure medical instrument of distalmost end to most proximal end.

Additionally or alternatively, and at the 19th aspect, cable release includes closest to one or more of cable release proximal end A indicant, these indicants are configured to how many instrument in the multiple closure medical instruments of user for informing blood vessel plugging system It has been released.

Additionally or alternatively, and at the 20th aspect, by the method for arterial embolism can include: make blood vessel plugging system Therapentic part is marched to inside artery, which includes the multiple closure for being separably connected to elongated shaft distal end Medical instrument and be slidably disposed on elongated shaft lumen and multiple each at least part of for blocking medical instrument Internal cable release；To nearside extract out cable release so as in therapentic part from being discharged in elongated shaft in multiple closure medical instruments One instrument；The distal end of an instrument in multiple closure medical instruments is positioned to be still attached to and is cured with the closure discharged Treat the adjacent elongated shaft of instrument；With further extract cable release out to nearside to discharge positioned closure doctor from elongated shaft Treat instrument.

Above the general introduction of some embodiments, aspect, and/or example is not intended to describe each embodiment of the invention Or each embodiment.These embodiments are more particularly exemplified in next attached drawing and detailed description.

Detailed description of the invention

Based on the detailed description below to various embodiments and in conjunction with attached drawing, the disclosure, In can be more fully understood In attached drawing:

Fig. 1 is the perspective view of exemplary blood vessel plugging system；

Fig. 2 is the partial sectional view of exemplary blood vessel plugging system；

Fig. 3 illustrates the exemplary attachment mechanism of exemplary blood vessel plugging system；

Fig. 4~Fig. 5 is the partial sectional view for illustrating the actuating of a part in exemplary blood vessel plugging system；

Fig. 6~Fig. 7 illustrates the actuating of the exemplary attachment mechanism of exemplary blood vessel plugging system；

Fig. 8 illustrates release of the multiple portions of exemplary blood vessel plugging system inside vascular system.

Although all aspects of this disclosure can have various modifications and alternative form, the citing passed through in the accompanying drawings is disclosed It its details and will be described in detail.It is to be understood, however, that being not intended to is that all aspects of this disclosure are confined to institute The specific embodiment of description.On the contrary, it is intended to be cover all modifications being fallen in spirit and scope of the present disclosure, equivalent, And substitute.

Specific embodiment

Description below should be read referring to attached drawing, these attached drawings are not necessarily drawn to scale, wherein all Similar appended drawing reference represents similar element in several views.The detailed description and the accompanying drawings are for illustrating and noting limit request The present invention of protection.It would be recognized by those skilled in the art that under the premise of without departing substantially from the scope of the present disclosure, it is described and/or Shown various elements can be used various combinations and construction and arrange.The detailed description and the accompanying drawings illustrate claimed hair Bright exemplary embodiment.

It, should be using these definition, unless in the claims or in the present specification for term defined below Other places provide different definition.

All numerical value hypothesis herein is modified by term " about ", regardless of whether it is manifestly intended that.Term " about " In It generally refers to those skilled in the art in the context of numerical value and would consider that be equal to cited value (for example, function having the same Or result) a series of numbers.In many cases, term " about " may include the number for being rounded to nearest effective digital Word.Other uses (for example, in context other than divider value) of term " about " may be assumed that with the common and common of them Definition, as the context based on this specification and consistent with the context of this specification understood, unless otherwise indicated.

Include all numbers in the range with the statement of endpoint logarithm range, (for example, 1 to 5 including endpoint Including 1,1.5,2,2.75,3,3.80,4 and 5).

Although disclosing some suitably sized, ranges, and/or value for being subordinated to various parts, feature and/or specification, But those skilled in the art will be understood that ideal size, range, and/or value can deviate bright under the inspiration by the disclosure Really disclosed size, range, and/or value.

Used singular " one (a) ", " a kind of (an) " and " this in the specification and the appended claims (the) " include plural referent, unless context it is manifestly intended that.It is used in the specification and the appended claims Term "or" be usually used with including its meaning of "and/or", unless context it is manifestly intended that.It should be understood that It is to understand for convenience, certain features of the disclosure can be described in the singular, even if these features can be plural number Or occur repeatedly in disclosed embodiment.The various situations of feature may include singular disclosure and/or by Singular disclosure included, unless specifically noted the contrary situation.For purposes of simplicity and clarity, the disclosed present invention All elements may not show in each attached drawing or discuss in detail later.It is to be understood, however, that opinion below Any and/or whole more than one component can be equally applicable to by stating, unless specifically noted the contrary situation.In addition, For the sake of clarity, all situations of some elements or features can not be shown in each attached drawing.

Relative terms, as " nearside ", " distal side ", " traveling ", " withdrawal " and their variant can be in various members Part relative to the instrument user/operator/operator positioning, direction, and/or operating aspect and consider, wherein " nearside " and " withdrawal " represent or refer to closer to or towards user and " distal side " and " travelings " representative or reference further from or Away from user.In some cases, in order to facilitate understanding of this disclosure, term " nearside " and " distal side " can be arbitrarily It is specified, and such case will readily appreciate that those skilled in the art.Other relative terms, as " on Trip ", " downstream ", " inflow " and " outflow " refer to fluid in lumen (such as body cavity, blood vessel) inside or instrument internal flow Direction.

Term " range " is understood to be expression and states or the greatest measurement of institute's dimensioning.For example, " outer range " It is understood to be expression maximum outside dimension, " radial extension " is understood to be expression maximum radial dimension, and " longitudinal extent " can quilt It is understood to mean that maximum longitudinal size etc.." range " it is various it may is that different (for example, axial, longitudinal, lateral , it is radial, circumferential, etc.), and this in the context based on exclusive use will be aobvious and easy for those skilled in the art See.In general, " range " can be considered as being measured size according to the maximum possible of desired use.In some cases, " range " It can usually measure with directly being handed in a plane and/or section, but as will become apparent to from specific context It is to measure in different ways, such as, but not limited to: angularly, radially, circumferentially (for example, along camber line) etc.. It should be noted that the citation to " embodiment ", " some embodiments ", " other embodiments " etc. in the present specification Indicate that described embodiment may include specific feature, structure or characteristic, but each embodiment may not necessarily include being somebody's turn to do Specific feature, structure or characteristic.Moreover, this phrase need not be directed to identical embodiment.In addition, when combining a reality Scheme is applied come when describing a specific feature, structure or characteristic, it will in the knowledge of those skilled in the range be Specific feature, structure or the characteristic is realized in combination with other embodiments, regardless of whether being explicitly described, unless clearly State opposite situation.That is, various individual components described below, even if not yet explicitly showing in specific combination Out, but it is also contemplated that they can be combined with each other or arrange, to constitute other other embodiments or supplement and/or Described embodiment is enriched, as will be appreciated by one of skill in the art.

For purposes of clarity, the numerical designation (for example, first, second, third, fourth etc.) of some identification can be entire It is used to name various described and/or claimed features and/or various described in description and/or claim And/or it is distinguish between claimed feature.It should be understood that numerical designation is not intended to be restrictive and is Illustratively.In some embodiments, in order to succinct and clear, can make with the change of the used numerical designation in front and partially Difference.That is, " second " element, " third " element etc. can be then referred to as by being denoted as the feature of " first " element, Or it can fully omit, and/or different features can be known as " first " element.Meaning in every case and/or Title will be apparent to those skilled in the art.

The disease and/or the patient's condition for influencing cardiovascular system and/or being influenced by cardiovascular system are stream in worldwide Capable.For example, some form of arterial-venous lopsided (AVM) can be maintained by the normal blood flow by vascular system. It is not intending to be bound by any theory, it is considered that can be by making them lack blood flow normal rich in oxygen and/or nutrient, and at least Thus locally treatment arterial-venous deformity and/or Other diseases or the patient's condition limit the ability that they grow and/or spread.It can Other examples of the disease or the patient's condition that benefit from blood vessel closure include but is not limited to: bleeding, aneurysm, venous insufficiency, In Blood flow is truncated before organ removal or prevents the embolism pearl reflux for entering branch vessel in liver.Medical treatment device disclosed herein Tool can be inside the cardiovascular system of a part using to treat and/or repair some arterial-venous deformities and/or other diseases Disease or the patient's condition.Instrument disclosed herein also can provide such as several in greater detail other desirable features and benefit hereinafter Place.

Fig. 1 and Fig. 2 illustrates the various aspects of exemplary blood vessel plugging system 100.The blood vessel plugging system 100 can wrap Elongated shaft 110 is included, which has the lumen for the distal end 116 that elongated shaft 110 is extended to from the proximal end of elongated shaft 110 114 112.In some embodiments, elongated shaft 110 can be conduit, hypotube or other similar tubular structures.It is hereinafter described Some suitable but unrestricted material, such as metal material, polymer material, composite material etc. for elongated shaft 110.

In some embodiments, blood vessel plugging system 100 may include microtubular 200, and the size of the microtubular 200 is set It counts into and it is configured to navigate in vascular system and/or multiple closure medical instruments 130 are delivered in blood vascular system The internal therapentic part of system (such as artery or vein).Elongated shaft 110 and multiple closure medical instruments 130 can slideably be set It sets inside the lumen 202 of microtubular 200.In some embodiments, microtubular 200 can be convenient for multiple closure medical instruments 130 subcutaneous deliveries are to vascular system and/or therapentic part.It has been hereinafter described for some suitable but unrestricted of microtubular 200 The material, such as metal material, polymer material, composite material etc. of property.

Blood vessel plugging system 100 may include the multiple closure medical instruments 130 for being separably connected to elongated shaft 110.In In some embodiments, multiple closure medical instruments 130 may include that the first closure medical instrument 132, second blocks medical instrument 134, and/or third block medical instrument 136.As needed, it can be used and/or add less and/or additional closure doctor Treat instrument.For simplicity, multiple closure medical instruments 130 are illustrated as multiple shape memory embolic coils herein, Such as treating aneurysmal embolic coil, such as but be transported, convey in a similar manner, use, release etc. other conjunctions Suitable closure medical instrument be also it is contemplated that, including but not limited to bracket, embolism filter, replacement valve, block instrument, And/or other medical implants etc..In some embodiments, at least one of multiple closure medical instruments 130 are volumes Around component, which is configured to first shape be presented when being connected to elongated shaft 110 and when separating with elongated shaft 110 The second shape is presented.At least one of multiple closure medical instruments 130 (for example, one, two, it is each etc.) may be configured to As seen in figures 1 and 2 elongated delivery configuration (for example, when being connected to elongated shaft 110) with such as Fig. 4 and seen in fig. 5 It is converted between deployed configuration (for example, when being separated with elongated shaft 110).In some embodiments, multiple closure medical instruments Each of 130 may be configured to that different shapes is being presented after being released in elongated shaft 110.It is more back to Fig. 1 and Fig. 2 A medical instrument 130 that blocks is can be configured to when being connected to elongated shaft 110 close to the distal end 116 of elongated shaft 110.In some realities It applies in scheme, multiple closure medical instruments 130 can be separably connected to elongated shaft 110 in order.

First closure medical instrument 132 can have the proximal end being arranged in 116 adjacent position of distal end of elongated shaft 110, and And second closure medical instrument 134 can have be arranged in first block medical instrument 132 distal end adjacent position proximal end.The Three closure medical instruments 136 can have the proximal end that the distal end adjacent position for blocking medical instrument 134 with second is arranged in.At least exist In some embodiments, in elongated delivery configuration, at least one of multiple closure medical instruments 130 can have and multiple envelopes Another different total length in stifled medical instrument 130.For example, third blocks medical instrument in elongated delivery configuration 136, which can be longer than the first closure medical instrument 132 and/or second, blocks medical instrument 134.In some embodiments, elongated It conveys in configuration, each multiple for blocking medical instrument 130 can have different total lengths.In some embodiments, In In elongated delivery configuration, each multiple for blocking medical instrument 130 can have similar total length.

In some embodiments, at least one of multiple closure medical instruments 130 can have and multiple closure medical treatment Another different rigidity of instrument 130.For example, in some embodiments, distalmost end in multiple closure medical instruments 130 One (for example, third block medical instrument 136) can have greater than any other multiple closure medical instruments 130 (for example, the One blocks medical instrument 132 and/or second blocks medical instrument 134) rigidity, thus for example convenient for being anchored and/or navigate to In the wall (for example, wall of lumen of vessels) of therapentic part.In some embodiments, most proximal end in multiple closure medical instruments 130 An instrument (for example, first closure medical instrument 132) can have less than any other in multiple closure medical instruments 130 The rigidity of one (for example, second blocks medical instrument 134 and/or third closure medical instrument 136), thus for example convenient for abutting Filling second block medical instrument 134 and/or third and block medical instrument 136.The difference of rigidity can be cured convenient for multiple closure Instrument 130 is treated inside vascular system and/or the positioning of therapentic part, placement, fixation, holding, and/or closure.In some realities It applies in scheme, each of multiple closure medical instruments can have similar rigidity.In some embodiments, multiple closure The distal top of an instrument (for example, third blocks medical instrument 136) for distalmost end can have non-wound in medical instrument 130 Property top, protrusion or distal end.It has been hereinafter described and has blocked some suitable but unrestricted of medical instrument 130 for multiple Material, such as metal material, polymer material, composite material, shape-memory material etc..

In some embodiments, one or more of multiple closure medical instruments 130 (for example, one, two, it is each It is a etc.) it may include multiple respective coil insides for blocking medical instrument 130 are set and/or are attached to the coil more Fiber and/or fabric or braided material.Be arranged in it is multiple block medical instruments 130 independent coil insides, be attached to and/or Person is embedded in the plurality of fibers of multiple respective coil insides for blocking medical instruments 130 and/or fabric or braided material and may be configured to Enhance the blood coagulation and/or closure of vascular system (for example, artery, vein etc.) and/or therapentic part.

Blood vessel plugging system 100 may also include one or more attachment mechanisms, and the attachment mechanism is by multiple closure Medical treatment devices Tool 130 is separably attached, attachment, and/or the distal end 116 fixed to elongated shaft 110.In some embodiments, blood vessel seals Stifled system 100 may include first be arranged between the distal end 116 of elongated shaft 110 and the proximal end of the first closure medical instrument 132 Attachment mechanism 170, wherein first attachment mechanism 170 includes first 172 and second 176.In some embodiments, blood Pipe plugging system 100 may include the proximal end that the distal end of the first closure medical instrument 132 is arranged in and blocks medical instrument 134 with second Between the second attachment mechanism 180, wherein second attachment mechanism includes third portion 182 and the 4th 186.In some embodiment party In case, blood vessel plugging system 100 may include distal end and the third closure medical instrument that the second closure medical instrument 134 is arranged in Third attachment mechanism 190 between 136 proximal end, wherein the third attachment mechanism 190 includes the 5th 192 and the 6th 196. Other details related with first, second and third attachment mechanism will be described hereinafter based on Fig. 3.

With continued reference to Fig. 1 and Fig. 2, blood vessel plugging system 100 may include cable release 120, which slideably sets Set the lumen 112 in elongated shaft 110 and multiple at least part of inside of each for blocking medical instrument 130.Cable release 120 may be configured to when at least part of inside of each for cable release 120 being arranged in multiple closure medical instruments 130 When, multiple closure medical instruments 130 are separably fixed and/or are attached to the distal end 116 of elongated shaft 110.In some implementations In scheme, cable release 120 can extend completely through at least one of multiple closure medical instruments 130.In some embodiment party In case, cable release 120 alternately and/or is interchangeably referred to as bracing wire, actuation wire, and/or lock wire.Cable release 120 is logical It often can be solid line or axis, but be also possible to tubulose in some embodiments.It has been hereinafter described for cable release 120 Some suitable but unrestricted material, such as metal material, polymer material, composite material etc..

Blood vessel plugging system 100 may include fixing component 140, which is fixedly attached to elongated shaft 110 It proximal end 114 and/or is extendd proximally from the proximal end of elongated shaft 110 114, and is fixedly attached to the close of cable release 120 Side and/or proximal end.Fixing component 140 may include proximal portion 142, distal portion 144 and extend from the proximal end of fixing component 140 To the wall of the distal end of fixing component 140.At least in some embodiments, the proximal portion 142 of fixing component 140 can be with fixed structure The distal portion 144 of part 140 is integrally formed as single overall structure.Be hereinafter described for some suitable of fixing component 140 but Unrestricted material, such as metal material, polymer material, composite material etc..

In some embodiments, be configured to can be with the distal portion of fixing component 140 for the proximal portion 142 of fixing component 140 144 are detached from.The proximal portion 142 of fixing component 140 can be fixedly attached to proximal portion and/or the proximal end of cable release 120.Fixed structure The distal portion 144 of part 140 can be fixedly attached to the proximal end 114 of elongated shaft 110.At least in some embodiments, fixed structure The outer surface of the distal portion 144 of part 140 can be fixedly attached to the inner surface of elongated shaft 110 (for example, limiting the table of lumen 112 Face).Alternatively, in some embodiments, the inner surface of the distal portion 144 of fixing component 140 can be fixedly attached to carefully The outer surface of long axis 110.In some embodiments, the proximal portion 142 of fixing component 140 can be formed in fixing component At joint portion 150 (for example, eyelet, designed frangible connection etc.) in 140 wall, it is detachably secured to the remote of fixing component 140 Side 144 and/or be configured to from the distal portion 144 of fixing component 140 be detached from.

At least in some embodiments, joint portion 150 may include a series of holes for extending through the wall of fixing component 140 Mouthful.In some embodiments, joint portion 150 can be extended circumferentially over upon around the wall whole circumference of fixing component 140.In some realities It applies in scheme, joint portion 150 can locally and/or discontinuously extend around the whole circumference of the wall of fixing component 140.Although one The aperture of series of exemplary can be round hole, but those skilled in the art will appreciate that other suitable shapes can also be used (for example, square, rectangle, oval, irregular shape etc.).For example, in some embodiments, joint portion 150 may include The series of rectangular notch of key dimension with circumferential orientation, the rectangular notch of the series extend through fixing component 140 Wall.In addition, though joint portion 150 be illustrated as being generally oriented and/or be located perpendicular to fixing component 140, elongated shaft 110, In the plane of the longitudinal axis of cable release 120, and/or blood vessel plugging system 100, but other orientations can also be used and/or determine Position.For example, in some embodiments, joint portion 150 and/or a series of aperture can be orientated and/or be located in and fixed structure Part 140, elongated shaft 110, cable release 120, and/or blood vessel plugging system 100 the inclined angle of longitudinal axis plane in or Person is along the planar orientation and/or positioning.For example non-planar shape of other shapes is also feasible.The nearside of fixing component 140 Portion 142 is arranged on the nearside at joint portion 150 and the distal portion 144 of fixing component 140 is arranged on the remote of joint portion 150 Side.As described above, the proximal portion 142 of fixing component 140 can be at the joint portion 150 in the wall for being formed in fixing component 140 It is detachably secured to the distal portion 144 of fixing component 140 and/or is configured to divide with the distal portion 144 of fixing component 140 It opens.

At least in some embodiments, designed frangible connection may include be formed in the wall of fixing component 140 be thinned and/ Or the feature (structure) or a series of feature of reduction, these features more easy fracture and/or separate compared with the rest part of wall. In some embodiments, designed frangible connection can surround the whole circumference of the wall of fixing component 140 and extend circumferentially over upon.Some In embodiment, designed frangible connection can partly and/or discontinuously extend around the whole circumference of the wall of fixing component 140.Gu The proximal portion 142 for determining component 140 is arranged on the nearside of designed frangible connection and the distal portion 144 of fixing component 140 is set In the distal side of designed frangible connection.As described above, the proximal portion 142 of fixing component 140 can be in the wall for being formed in fixing component 140 In designed frangible connection at be detachably secured to the distal portion 144 of fixing component 140 and/or be configured to and fixing component 140 distal portion 144 separates.

In some embodiments, the joint portion 150 of fixing component 140 may include both eyelet and designed frangible connection.Example Such as, eyelet can be formed in inside designed frangible connection.In some embodiments, a part of the circumference of fixing component 140 can wrap Eyelet is included, while the different piece of the circumference of fixing component 140 may include designed frangible connection.Others combination and/or configuration It is contemplated that.

At least in some embodiments, fixing component 140 can prevent the proximal portion 142 and fixation in fixing component 140 Cable release 120 is relative to elongated shaft 110 and/or multiple medical instruments 130 that block before the distal portion 144 of component 140 separates Axial translation.The distal portion 144 of the proximal portion 142 and fixing component 140 that make fixing component 140 separately allows cable release 120 Relative to the distal portion 144 of fixing component 140, elongated shaft 110, and/or multiple axial translations for blocking medical instrument 130.It changes Sentence is talked about, and the wall of the distal portion 144 of fixing component 140 can limit lumen, and wherein cable release 120 is slideably arranged on fixation Inside the lumen of the distal portion 144 of component 140.When the proximal portion 142 of fixing component 140 and the distal portion 144 of fixing component 140 When separating, such as such as Fig. 4 and seen in fig. 5, proximal portion 142 relative to the distal portion 144 of fixing component 140, elongated shaft 110, And/or multiple axial translations for blocking medical instrument 130 can make cable release 120 relative to elongated shaft 110 and/or fixing component 140 distal portion 144 and translate so as to from being discharged in the distal end of elongated shaft 110 116 in multiple closure medical instruments 130 at least It one, will such as be described in more detail herein.

In some embodiments, and as shown in Figure 3, the first attachment mechanism 170, the second attachment mechanism 180 and/ Or third attachment mechanism 190 can be constituted in a substantially similar fashion.Be hereinafter described for the first attachment mechanism 170, The some suitable but unrestricted material of second attachment mechanism 180, and/or third attachment mechanism 190, such as metal material, Polymer material, composite material etc..

First attachment mechanism 170 can include: have and be configured to slideably in the first longitudinal direction for wherein receiving cable release 120 First 172 of lumen 174 and with being configured to receive the second longitudinal direction lumen 178 of cable release 120 slidably therein Second 176.First 172 of first attachment mechanism 170 can be fixedly attached to the distal end 116 of elongated shaft 110, and first Second 176 of attachment mechanism 170 can be fixedly attached to the proximal end of the first closure medical instrument 132.First attachment mechanism 170 First 172 and second 176 of the first attachment mechanism 170 may be configured to it is interlocked with one another so that when the first attachment mechanism 170 First 172 surface abut and/or engagement the first attachment mechanism 170 second 176 surface and first attachment machine Second 176 of first 172 first longitudinal direction lumen 174 of structure 170 and the first attachment mechanism 170 with second longitudinal direction lumen 178 when being coaxially aligned, prevent second 176 of first 172 of the first attachment mechanism 170 and the first attachment mechanism 170 it Between axially opposite translation.In addition, in some embodiments, first 172 of the first attachment mechanism 170 and the first attachment machine Second 176 of structure 170 may be configured to it is interlocked with one another so that when the first attachment mechanism 170 first 172 surface against And/or second 176 surface of the first attachment mechanism 170 of engagement, the first of first 172 of the first attachment mechanism 170 are vertical It is coaxially aligned to lumen 174 with second 176 of the first attachment mechanism 170 second longitudinal direction lumen 178, and cable release 120 slideably with first 172 of the first attachment mechanism 170 first longitudinal direction lumen 174 and the first attachment mechanism 170 When two 176 second longitudinal direction lumens 178 engage, first 172 and the first attachment mechanism of the first attachment mechanism 170 are prevented Opposite lateral translation between second 176 of 170.

Second attachment mechanism 180 can include: have and be configured to slideably wherein receiving the third of cable release 120 longitudinal The third portion 182 of lumen 184 and with being configured to slideably in the 4th longitudinal direction tube chamber 188 for wherein receiving cable release 120 4th 186.The third portion 182 of second attachment mechanism 180 can be fixedly attached to the distal end of the first closure medical instrument 132, And the 4th 186 of the second attachment mechanism 180 can be fixedly attached to the proximal end of the second closure medical instrument 134.Second is attached The 4th 186 of the third portion 182 of connection mechanism 180 and the second attachment mechanism 180 may be configured to it is interlocked with one another so that when second attached The surface in the third portion 182 of connection mechanism 180 abuts and/or the 4th 186 surface of the second attachment mechanism 180 of engagement and the 4th longitudinal direction tube chamber 188 of the third portion 182 of the third longitudinal direction tube chamber 184 of two attachment mechanisms 180 and the second attachment mechanism 180 When being coaxially aligned for the 4th 186, prevent the second attachment mechanism 180 third portion 182 and the 4th of the second attachment mechanism 180 Axially opposite translation between 186.In addition, in some embodiments, the third portion 182 and second of the second attachment mechanism 180 The 4th 186 of attachment mechanism 180 may be configured to it is interlocked with one another so that when the second attachment mechanism 180 third portion 182 surface Abut and/or engage the 4th 186 surface of the second attachment mechanism 180, the third longitudinal direction tube chamber of the second attachment mechanism 180 The 4th 186 of 184 third portion 182 and the 4th longitudinal direction tube chamber 188 of the second attachment mechanism 180 is coaxially aligned, and releases The 4th of the third longitudinal direction tube chamber 184 in the third portion 182 of unwrapping wire 120 and the second attachment mechanism 180 and the second attachment mechanism 180 When 186 the 4th longitudinal direction tube chamber 188 slidably engages, third portion 182 and the second attachment machine of the second attachment mechanism 180 are prevented Opposite lateral translation between the 4th 186 of structure 180.

Third attachment mechanism 190 can include: have be configured to receive cable release 120 slidably therein the 5th vertical To the 5th 192 of lumen 194 and with being configured to receive the 6th longitudinal direction tube chamber 198 of cable release 120 slidably therein The 6th 196.The 5th 192 of third attachment mechanism 190 can be fixedly attached to the remote of the second closure medical instrument 134 End, and the 6th 196 of third attachment mechanism 190 can be fixedly attached to the proximal end that third blocks medical instrument 136.Third The 5th 192 of attachment mechanism 190 may be configured to the 6th 196 of third attachment mechanism 190 it is interlocked with one another so that working as third 5th 192 surface of attachment mechanism 190 abut and/or the 6th 196 surface of engagement third attachment mechanism 190 and 6th longitudinal direction tube chamber 198 of the 5th longitudinal direction tube chamber 194 and third attachment mechanism 190 of the 5th 192 of third attachment mechanism 190 The 6th 196 when being coaxially aligned, prevent the 6th of the 5th 192 of third attachment mechanism 190 and third attachment mechanism 190 Axially opposite translation between portion 196.In addition, in some embodiments, the 5th 192 of third attachment mechanism 190 and The 6th 196 of three attachment mechanisms 190 may be configured to it is interlocked with one another so that work as third attachment mechanism 190 the 5th 192 table Face abuts and/or the 6th 196 surface of engagement third attachment mechanism 190, the 5th 192 of third attachment mechanism 190 5th longitudinal direction tube chamber 194 is coaxially aligned with the 6th 196 of third attachment mechanism 190 the 6th longitudinal direction tube chamber 198, and is released The 6th of the 5th 192 the 5th longitudinal direction tube chamber 194 and third attachment mechanism 190 of unwrapping wire 120 and third attachment mechanism 190 When 196 the 6th longitudinal direction tube chamber 198 slidably engages, the 5th 192 and third attachment machine of third attachment mechanism 190 are prevented Opposite lateral translation between the 6th 196 of structure 190.

Fig. 4 and Fig. 5 generally illustrates for example multiple at least one instrument blocked in medical instruments 130 by from elongated shaft (such as in therapentic part) is released in 110 distal end 116.It in use, can be by the microtubular 200 of blood vessel plugging system 100 It is inserted into anatomical structure and/or the vascular system of patient, and will distally guide and/or march to close to the position of therapentic part It sets.Multiple closure medical instruments 1301 insertion that the distal end 116 of elongated shaft 110 can will be arranged in is arranged inside microtubular 200 Lumen 202 proximal end, and march to therapentic part by microtubular 200.It in some embodiments, can be by multiple closure Medical instrument 130 is arranged in the inside of lumen 202 of microtubular 200 and close to the distal end of elongated shaft 110 116.In some embodiment party It, can will be multiple before the use and/or before microtubular 200 to be inserted into anatomical structure and/or the vascular system of patient in case It blocks medical instrument 130 and the inside of lumen 202 of microtubular 200 is set and close to the distal end of elongated shaft 110 116.

According to the type and/or desired therapeutic process or method for blocking medical instrument, multiple envelopes are optionally executed The arrangement and/or release of at least one instrument in stifled medical instrument 130.It has been found that due to the variation of vascular system size, In The reasons such as the expansion of plaque deposits, vascular system inside vascular system, thus, vascular system is suitably blocked (for example, dynamic Arteries and veins, vein etc.) or therapentic part needed for block medical instrument (for example, embolic coil etc.) exact amount can be it is unknown, directly It has been carried out to treatment procedure.If the closure medical instrument quantity being initially provided of to therapentic part is insufficient, standard may require that It is inserted into the vascular system of patient for other closure medical instrument and via other blood vessel plugging system, therefore extends Treatment procedure simultaneously increases any adjoint risk for being directed to patient.In order to reduce the duration for the treatment of procedure and arrange And/or release requirement blocks in medical instrument and provides more flexibilities, has developed thin including being separably connected to The blood vessel plugging system 100 of multiple closure medical instruments 130 of the distal end 116 of long axis 110.Use blood vessel described herein Plugging system 100, operator can selectively arrange one in multiple closure medical instruments 130 based on the requirement individually performed the operation It is a or multiple, and single blood vessel plugging system is only needed, therefore reduce the total cost for the treatment of procedure duration and treatment procedure (due to less blood vessel plugging system and adopted adjoint encapsulation, preparing the reasons such as requirement).

When prepare therapentic part arrange it is multiple closure medical instruments 130 at least one when, 110 phase of elongated shaft can be made Microtubular 200 is distally advanced and/or translated until at least one instrument exposure in multiple closure medical instruments 130 And/or it is set to the distal side of microtubular 200.Elongated shaft 110 can have sufficient length, so that when multiple closure medical instruments 130 when being arranged in the distal side of microtubular 200, and the proximal end 114 of elongated shaft 110 and/or fixing component 140 are still in microtubular 200 Nearside (for example, being extendd proximally from microtubular 200).In use, elongated shaft 110 and microtubular 200 can have adequately Length, so that treatment site reaches being manipulated by operator (for example, clinician, doctor, user etc.) for patient-external The position of blood vessel plugging system 100.Then, first hand can be placed in fixing component by the operator of blood vessel plugging system 100 On 140 distal portion 144, and second hand is placed in the proximal portion 142 of fixing component 140.The nearside of fixing component 140 Portion 142 may be configured to when the distal position of microtubular 200 is arranged in multiple closure medical instruments 130, close in microtubular 200 The proximal position at end and the distal portion 144 of fixing component 140 separate.At least in some embodiments, by relative to fixation The bending of distal portion 144, torsion, and/or the proximal portion 142 for pulling fixing component 140 of component 140, can make fixing component 140 Proximal portion 142 is separated with the distal portion 144 of fixing component 140.In some embodiments, make the proximal portion of fixing component 140 142 to separate with the distal portion 144 of fixing component 140 may include making the proximal portion 142 of fixing component 140 relative to fixing component 140 distal portion 144 and move, so that the proximal portion 142 of fixing component 140 and the distal portion 144 of fixing component 140 be made to divide From.In some embodiments, the proximal portion 142 of fixing component 140 and the distal portion 144 of fixing component 140 be wrapped separately can Include makes the proximal portion 142 of fixing component 140 relative to fixed structure using external device (ED) (for example, torquer, outer handle etc.) The distal portion 144 of part 140 and move.

When making the proximal portion 142 of fixing component 140 separate and/or separate with the distal portion 144 of fixing component 140, such as It is seen in fig. 4, put down cable release 120 relative to elongated shaft 110 and/or multiple closure medical instruments 130 in a proximal direction It moves, to discharge the 6th of third attachment mechanism 190 from the 5th 192 of third attachment mechanism 190 and/or elongated shaft 110 196 and/or third block medical instrument 136 (for example, from the distal end of elongated shaft 110 116 discharge third block medical instrument 136).When making cable release 120 block medical instrument 136 to proximal translation and/or extraction relative to elongated shaft 110 and/or third When, third blocks medical instrument 136 and is released from the distal end of elongated shaft 110 116 and from first shape and/or elongated delivery Configuration transforms to the second shape and/or deployed configuration.

In some embodiments, cable release 120 may include being positioned close to the one or more of 120 proximal end of cable release to refer to Show object 128, the indicant 128 be configured to display cable release 120 extracted degree and/or be configured to inform blood vessel envelope The multiple degree and quantity for blocking medical instruments 130 and being released of the user of stifled system 100, such as such as institute in figures 4 and 5 See.One or more indicants 128 may include straight line, retainer (spine), color, notch or other suitable indicants.Solid Determine after the proximal portion 142 of component 140 separates at the joint portion 150 as described above with the distal portion 144 of fixing component 140, One or more indicants 128 can be seen between the proximal portion 142 of fixing component 140 and the distal portion 144 of fixing component 140 (if visible).

An instrument in multiple closure medical instruments 130 is discharged (for example, third blocks medical instrument in therapentic part 136) after, blood vessel plugging system 100 and/or elongated shaft 110 can if necessary distally advanced, to will be still attached to In multiple closure medical instruments 130 of the distal end of elongated shaft 110 116 an instrument (for example, second block medical instrument 134 and/ Or first closure medical instrument 132) distal end be positioned adjacent to release closure medical instrument (for example, third block Medical treatment device Tool 136).Then, cable release 120 can be made relative to elongated shaft 110 and/or multiple closure medical instruments 130 further to nearside Translation, to discharge oriented closure medical instrument (for example, second blocks medical instrument from the distal end of elongated shaft 110 116 134 and/or first block medical instrument 132), such as such as seen in fig. 5.It is blocked when relative to elongated shaft 110 and/or second Medical instrument 134 by cable release 120 to proximal translation and/or extraction when, second blocks medical instrument 134 from elongated shaft 110 Distally 116 it is released and transforms to the second shape and/or deployed configuration from first shape and/or elongated delivery configuration.

Two instruments in multiple closure medical instruments 130 are discharged (for example, second blocks medical instrument in therapentic part 134 and third block medical instrument 136) after, blood vessel plugging system 100 and/or elongated shaft 110 can be made if necessary distad Advance, thus by it is multiple closure medical instruments 130 in be still attached to elongated shaft 110 distal end 116 an instrument (for example, First closure medical instrument 132) distal end be positioned adjacent to discharge block medical instrument (for example, third closure medical instrument 136 and/or second block medical instrument 134).Then, cable release 120 can be made to cure relative to elongated shaft 110 and/or multiple closure Instrument 130 is treated further to proximal translation, to discharge oriented closure medical instrument (example from the distal end of elongated shaft 110 116 Such as, first medical instrument 132 is blocked).When blocking medical instrument 132 for cable release 120 relative to elongated shaft 110 and/or first When to proximal translation and/or extraction, the first closure medical instrument 132 is released from the distal end of elongated shaft 110 116 and from first Shape and/or elongated delivery configuration transform to the second shape and/deployed configuration.

Fig. 6 and Fig. 7 illustrate for it is described herein it is multiple block medical instruments 130 substitutions attachment and/ Or relieving mechanism.It is illustrated to replace although being illustrated for the distal end 116 of the first closure medical instrument 132 and elongated shaft 110 Generation attachment and/or relieving mechanism can be used for any of multiple closure medical instruments 130 and/or each.Attached using substituting Connect and/or the embodiment of relieving mechanism in, blood vessel plugging system 100 may also include the second cable release 122, second cable release 122 are slidably disposed on the lumen 112 of elongated shaft 110 and multiple at least part of each for blocking medical instrument 130 Inside.Second cable release 122 may include being fixedly attached to and/or being arranged in the spherical tips of 122 distal end of the second cable release 124, wherein the spherical tips 124 have the overall diameter of the overall diameter greater than the second cable release 122.When cable release 120 and When two cable releases 122 are slidably disposed on multiple each at least part of internal for blocking medical instruments 130, release Line 120 extends to the distal side of the spherical tips 124 of the second cable release 122.

Blood vessel plugging system 100 may also include fixing component 126, which is fixedly attached to multiple closure Each of medical instrument 130 is (for example, first blocks the closure medical instrument 134 of medical instrument 132, second, and/or third envelope Stifled medical instrument 136) proximal end.Cable release 120 and the second cable release 122 may be configured to discharge when cable release 120 and second Line 122 is arranged in multiple at least part of inside of each for blocking medical instrument 130 and/or when cable release 120 When simultaneously extending past fixing component 126 with 122 the two of the second cable release, separably by multiple closure medical instruments 130 Connection, attachment, and/or the distal end 116 fixed to elongated shaft 110.When both cable release 120 and the second cable release 122 simultaneously When extending past fixing component 126, for example, as shown in Figure 6, due to mutual between spherical tips 124 and fixing component 126 Effect, thus the second cable release 122 is prevented to be extracted by fixing component 126.

Cable release 120 and then the second release are extracted out to nearside by fixing component 126 and/or relative to elongated shaft 110 Line 122 discharges an instrument in multiple closure medical instruments 130 (for example, first blocks doctor from the distal end of elongated shaft 110 116 It treats instrument 132, second and blocks medical instrument 134, and/or third closure medical instrument 136).For example, by passing through fixing component 126 extraction cable releases 120, allow the second cable release 122 with its contact and/or pass through fixing component 126 and radially inward partially Turn, rather than interact when spherical tips 124 contact fixing component 126 with fixing component 126, wherein cable release 120 is used In preventing spherical tips 124 from deflecting.Therefore, cable release 120 and then the second cable release 122 by fixing component 126 and/ Or it is discharged in multiple closure medical instruments 130 relative to extracting out to nearside from the distal end of elongated shaft 110 116 for elongated shaft 110 One instrument (for example, first blocks medical instrument 132, for example, as shown in FIG. 7).As described above, identical process can fit For each multiple for blocking medical instrument 130.

In some embodiments, cable release 120 and the second cable release 122 can fully extend past multiple closure medical treatment At least one instrument in instrument 130.In some embodiments, cable release 120 and the second cable release 122 can fully extend Medical instrument 132 and second is blocked by first and blocks medical instrument 134, and is extended into third and blocked medical instrument 136 In at least part.In some embodiments, cable release 120 and then the second cable release 122 relative to elongated shaft 110 and/ Or it is multiple block medical instruments 130 to nearside extract out, successively from the closure medical instrument of distalmost end (for example, third block Medical instrument 136) to most proximal end multiple closure of closure medical instrument (for example, first block medical instrument 132) release it is medical Each of instrument 130.In some embodiments, the second cable release 122 alternatively and/or is interchangeably referred to as drawing Line, actuation wire, and/or lock wire.Second cable release 122 usually can be solid line or axis, but in some embodiments It is also possible to tubulose.The some suitable but unrestricted material for the second cable release 122, such as metal has been hereinafter described Material, polymer material, composite material etc..

Blood vessel plugging system 100 can be used in vascular system (for example, artery, vein etc.) is subject to the method for embolism, Fig. 8 In illustrate the various aspects of this method.This method may include blocking blood vessel inside vascular system (for example, artery, vein etc.) System 100 marches to therapentic part.As described above, blood vessel plugging system 100 may include being separably connected to elongated shaft 110 Distally 116 multiple closure medical instruments 130 and be slidably disposed on elongated shaft 110 lumen 112 and multiple closure medical treatment The cable release 120 of at least part of inside of each of instrument 130.

This method, which may also include, extracts cable release out to nearside relative to elongated shaft 110 and/or multiple closure medical instruments 130 120, to discharge multiple instruments blocked in medical instruments 130 from the distal end of elongated shaft 110 116 in therapentic part.Example It such as, can be by being attached from third to nearside extraction cable release 120 relative to elongated shaft 110 and/or multiple closure medical instruments 130 The 6th 196 of the 5th 192 of mechanism 190 release third attachment mechanism 190, and in therapentic part from the remote of elongated shaft 110 116 release third of end blocks medical instrument 136.At least in some embodiments, third blocks medical instrument 136 (for example, more A instrument blocked in medical instrument 130) may be configured in wall in vascular system (for example, artery, vein etc.) and/or Therewith abut ground and/or therapentic part inside, from first shape and/or elongated delivery configuration transform to the second shape and/or Deployed configuration.In some embodiments, third blocks medical instrument 136 (for example, multiple one blocked in medical instrument 130 A instrument) it may be configured in wall in vascular system (for example, artery, vein etc.) and/or abut therewith and/or therapentic part The configuration and/or shape of substantially helical shape is presented in inside.Other configurations and/or shape are also to be contemplated that.In some realities It applies in scheme, third closure medical instrument 136 (for example, multiple instrument blocked in medical instrument 130), which can have, to be greater than Any other multiple rigidity for blocking medical instrument 130, so as to internal and/or control in vascular system (for example, artery, vein etc.) It treats position and forms reliable " base portion " or " fixation ", thus prevent the displacement of multiple closure medical instruments 130 arranged.

This method may also include the distal end 116 for being still connected to elongated shaft 110 in multiple closure medical instruments 130 The distal end of one instrument (for example, the second closure medical instrument 134, first blocks medical instrument 132 etc.), which is positioned adjacent to, has released The closure medical instrument (for example, third blocks medical instrument 136, multiple instrument blocked in medical instrument 130 etc.) put. For example, this method may include determining the 5th 192 of the distal end of the second closure medical instrument 134 and/or third attachment mechanism 190 Position blocks medical instrument 136 at close to third, which, which blocks, is disposed in vascular system (for example, dynamic before medical instrument 136 Arteries and veins, vein etc.) and/or therapentic part inside.

This method, which may also include, extracts cable release out to nearside relative to elongated shaft 110 and/or multiple closure medical instruments 130 120, to discharge positioned closure medical instrument (for example, second blocks from the distal end of elongated shaft 110 116 in therapentic part Medical instrument 134).For example, cable release 120 is extracted out to nearside relative to elongated shaft 110 and/or multiple closure medical instruments 130, It can be and from the 4th 186 of the second attachment mechanism 180 of the third portion 182 of the second attachment mechanism 180 release in therapentic part Medical instrument 134 is blocked from the release of the distal end of elongated shaft 110 116 second.At least in some embodiments, second medical treatment is blocked Instrument 134 (for example, closure medical instrument of positioning) may be configured in vascular system (for example, artery, vein etc.) and/or treatment Part interior transforms to the second shape and/or deployed configuration from first shape and/or elongated delivery configuration.In some embodiments In, the second closure medical instrument 134 closure medical instrument of positioning (for example) may be configured to vascular system (for example, artery, Vein etc.) and/or therapentic part inside present be different from third block medical instrument 136 configuration and/or the second shape.One In a little embodiments, the second closure medical instrument 134 (for example, closure medical instrument of positioning), which can be presented, to be generally randomized And/or irregular second shape.Other configurations and/or shape are also to be contemplated that.In some embodiments, the second envelope Stifled medical instrument 134 (for example, closure medical instrument of positioning), which can have, blocks medical instrument 136 (for example, multiple less than third Block medical instrument 130 in one) rigidity, thus allow abut third block medical instrument 136, inside it, and/or More easily " clogging " for its second closure medical instrument 134 is surrounded, so that filling and/or closure vascular system are (for example, dynamic Arteries and veins, vein etc.) and/or therapentic part.

Two instruments in multiple closure medical instruments 130 are discharged (for example, second blocks medical instrument in therapentic part 134 and third block medical instrument 136) after, this method, which may also include, to be still connected in multiple closure medical instruments 130 The distal end of an instrument (for example, first closure medical instrument 132) for the distal end 116 of elongated shaft 110, which is positioned adjacent to, to be discharged Medical instrument is blocked (for example, second blocks medical instrument 134 and/or third closure medical instrument 136, multiple closure Medical treatment devices Instrument in tool 130 etc.).For example, this method may include that the distal end for blocking medical instrument 132 for first and/or second are attached The third portion 182 of connection mechanism 180 is positioned adjacent to front and is disposed in vascular system (for example, artery, vein etc.) and/or treatment The third of part interior blocks medical instrument 136 and/or the second closure medical instrument 134.

This method, which may also include, extracts cable release out to nearside relative to elongated shaft 110 and/or multiple closure medical instruments 130 120, to discharge positioned closure medical instrument (for example, first blocks from the distal end of elongated shaft 110 116 in therapentic part Medical instrument 132).For example, extracting cable release 120 out to nearside relative to elongated shaft 110 and/or multiple closure medical instruments 130 It can be by from second 176 of first 172 of the first attachment mechanism 170 the first attachment mechanism 170 of release, and in therapentic part Medical instrument 132 is blocked from the release of the distal end of elongated shaft 110 116 first.At least in some embodiments, first medical treatment is blocked Instrument 132 (for example, the stifled medical instrument positioned) may be configured in vascular system (for example, artery, vein etc.) and/or treatment Part interior transforms to the second shape and/or deployed configuration from first shape and/or elongated delivery configuration.In some embodiments In, the first closure medical instrument 132 closure medical instrument of positioning (for example) may be configured to vascular system (for example, artery, Vein etc.) and/or therapentic part inside present be different from third block medical instrument 136 and/or second block medical instrument 134 Configuration and/or the second shape.In some embodiments, first medical instrument 132 is blocked (for example, the closure medical treatment of positioning Instrument) generally randomization and/or irregular second shape can be presented.Other configurations and/or shape are also to be contemplated that. In some embodiments, the first closure medical instrument 132 (for example, the closure medical instrument positioned) can have less than third Block medical instrument 136 and/or second block medical instrument 134 (for example, it is multiple block medical instrument 130 in one) it is rigid Degree, this allows to abut third and blocks medical instrument 136 and/or the second closure medical instrument 134, inside it, and/or surrounds Its (they) first block medical instrument 132 easier " filling ", so as to fill and/or block vascular system (for example, Artery, vein etc.) and/or therapentic part.

In some embodiments, cable release 120 relative to elongated shaft 110 and/or it is multiple block medical instrument 130 to Nearside extraction, successively from the distalmost end of closure medical instrument (for example, third blocks medical instrument 136) to closure medical instrument The most proximal end of (for example, first closure medical instrument 132) discharges each multiple for blocking medical instrument 130.

The various parts in blood vessel plugging system 100, elongated shaft 110, cable release 120, the second cable release can be used 122, fixing component 126, multiple closure medical instruments 130, fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, third attachment mechanism 190, microtubular 200 etc. (and/or other systems disclosed herein) and disclosed herein The material of their various elements may include material usually relevant to medical instrument.For simplicity purposes, discussion below With reference to blood vessel plugging system 100, elongated shaft 110, cable release 120, the second cable release 122, fixing component 126, multiple closure Medical instrument 130, the first attachment mechanism 170, the second attachment mechanism 180, third attachment mechanism 190, micro- is led fixing component 140 Pipe 200 etc..However, this is not intended to limit instrument described herein and method, it is equally applicable to herein because discussing Disclosed other elements, component, component or instrument, such as, but not limited to: first, which blocks medical instrument 132, second, blocks doctor Treat instrument 134, third blocks medical instrument 136, first 172, second 176, third portion 182, the 4th 186, the 5th 192, the 6th 196 etc., and/or their element or component.

In some embodiments, blood vessel plugging system 100, elongated shaft 110, cable release 120, the second cable release 122, solid Determine component 126, multiple closure medical instruments 130, fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, (such as, but not limited to: first blocks medical instrument 132, for three attachment mechanisms 190, microtubular 200 etc., and/or their component Two block medical instrument 134, third blocks medical instrument 136, first 172, second 176, third portion 182, the 4th 186, the 5th 192, the 6th 196 etc.) it can be by metal, metal alloy, polymer (disclosing its some examples hereinafter), gold Made by category-polymer composites, ceramics, their combination etc. or other suitable materials.Suitable metal and metal close Some examples of gold include: stainless steel, such as 444V, 444L and 314LV stainless steel；Mild steel；Ni-Ti alloy (such as linear elasticity and/ Or superelastic NiTi alloy)；Other nickel alloys, if Ni-Cr-Mo alloy is (for example, UNS:N06625 is such as 625, UNS:N06022 such asUNS:N10276 is such as It is otherAlloy, etc.), nickel-copper alloy is (for example, UNS:N04400 is such as400,400,400 etc.), nickel-cobalt-chromium-molybdenum alloy is (for example, UNS:R44035 is such as Deng), nickel-molybdenum alloy is (for example, UNS:N10665 such as has), other nickel-chromium alloy, Other nickel-molybdenum alloys, other nickel-cobalt alloys, other nickel-ferro alloys, other nickel-copper alloys, other nickel-tungstens or tungsten close Gold etc.；Cobalt-chromium alloy；Cobalt-chromium-molybdenum alloy is (for example, UNS:R44003 is such asDeng)；It is rich The stainless steel of platiniferous；Titanium；Platinum；Palladium；Gold；Their combination；Deng；Or made by any other suitable material.

It as mentioned in this article, in the family of commercially available Ni-Ti or Nitinol alloy is to be named as " line bullet One classification of property " or " non-super-elasticity ", although the category can be similar to conventional shape memory and superlastic in the chemically Property type, but unique and useful mechanical performance can be presented.Linear elasticity and/or non-hyperelastic Nitinol can be with super-elasticity Nitinol distinguished, that is, linear elasticity and/or non-hyperelastic Nitinol do not shown in its stress/strain curves it is bright Aobvious " super-elasticity is flat " or " logo area " similar to superelastic NiTi alloy.On the contrary, in linear elasticity and/or non-superelastic nickel In titanium alloy, when recoverable strain increases, stress continues with general linear or slightly but need not linear pass fully System and increase until plastic deformation starts, or at least with flat with the super-elasticity that can be seen in superelastic NiTi alloy And/or logo area increases compared to more linear relationship.Therefore, for purposes of this disclosure, linear elasticity and/or non-super-elasticity Nitinol is also referred to as " generally " linear elasticity and/or non-hyperelastic Nitinol.

In some cases, linear elasticity and/or non-hyperelastic Nitinol can also be distinguished with superelastic NiTi alloy Not, that is, the acceptable strain for being up to about 2~5% of linear elasticity and/or non-superelastic NiTi alloy while still substantially bullet Property (for example, before plastic deformation), and superelastic NiTi alloy before plastic deformation be subjected to be up to about 8% strain.This two Kind material can be with other linear elastic materials such as stainless steel (its of only about 0.2 to 0.44% strain acceptable before plastic deformation Can also be distinguished based on its composition) it is distinguished.

In some embodiments, linear elasticity and/or non-superelastic nickel-titanium alloy are that do not show can be by differential scanning amount Any martensite/austenite phase transformation detected in big temperature range of thermal method (DSC) and dynamic metal heat analysis (DMTA) Alloy.For example, in some embodiments, in linear elasticity and/or non-hyperelastic Ni-Ti alloy, can be not present can Pass through the martensite/austenite phase transformation that DSC and DMTA analysis is detected within the scope of about -60 degrees Celsius (DEG C) to about 120 DEG C. Therefore, the mechanical bend performance of this material is inertia usually for the temperature within the scope of temperature very wide herein influences. In some embodiments, the mechanical bend of linear elasticity and/or non-hyperelastic Ni-Ti alloy at ambient or room temperature Can be substantially the same with mechanical performance under body temperature, such as that is, they do not show hyperelastic flat and/or logo area.It changes Sentence is talked about, and over a wide temperature range, linear elasticity and/or non-hyperelastic Ni-Ti alloy keep its linear elasticity and/or non-superlastic The characteristic and/or performance of property.

In some embodiments, linear elasticity and/or non-hyperelastic Ni-Ti alloy can be containing in about 50 to about 60 weights Measure the nickel within the scope of %, remaining substantially titanium.In some embodiments, composition of alloy is in about 54 to about 57 weight % Nickel in range.One example of suitable Ni-Ti alloy is bought from Kanagawa, Japan Furukawa technologic material company FHP-NT alloy.Other suitable materials may include ULTANIUM^TM(being bought from Neo-Metrics company) and GUM MENTAL^TM (being bought from Toyota Company).In some of the other embodiments, superelastic alloy, such as superelastic NiTi alloy and reality can be used Existing desired performance.

At least in some embodiments, all or part of blood vessel plugging system 100, elongated shaft 110, cable release 120, Second cable release 122, fixing component 126, multiple closure medical instruments 130, fixing component 140, the first attachment mechanism 170, Two attachment mechanisms 180, third attachment mechanism 190, microtubular 200 etc., and/or their component, it is also possible to radiopaque material into Row doping is made or comprising the material of the material.Radiopaque material is construed as during medical procedure can be The material of relatively bright image is generated on fluorescent screen or using another imaging technique.The relatively bright image helps user Determine blood vessel plugging system 100, elongated shaft 110, cable release 120, the second cable release 122, fixing component 126, multiple closure doctor Treat instrument 130, fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, third attachment mechanism 190, microtubular 200 equal positions.Some examples of radiopaque material can include but is not limited to: gold, platinum, palladium, tantalum, tungsten alloy, use are impermeable The polymer material of ray filler load, etc..In addition, blood vessel can also be incorporated to for other radiopaque label bands and/or coil Plugging system 100, elongated shaft 110, cable release 120, the second cable release 122, fixing component 126, multiple closure medical instruments 130, fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, third attachment mechanism 190, microtubular 200 etc. In design, to obtain identical result.

In some embodiments, a degree of magnetic resonance imaging (MRI) compatibility is assigned to blood vessel plugging system 100, elongated shaft 110, cable release 120, the second cable release 122, fixing component 126, multiple closure medical instruments 130, fixed structure Part 140, the first attachment mechanism 170, the second attachment mechanism 180, third attachment mechanism 190, microtubular 200 etc..For example, blood vessel seals Stifled system 100, elongated shaft 110, cable release 120, the second cable release 122, fixing component 126, multiple closure medical instruments 130, Fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, third attachment mechanism 190, microtubular 200 etc., and/or Their each part or part can be by indistinctively making image fault and generating the material of obvious pseudomorphism (for example, gap in image) Material does made.Such as certain ferromagnetic materials can be inappropriate, because they can produce the pseudomorphism in MRI image.Blood vessel envelope Stifled system 100, elongated shaft 110, cable release 120, the second cable release 122, fixing component 126, multiple closure medical instruments 130, Fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, third attachment mechanism 190, microtubular 200 etc. or it Each section, can also be as made by the material that MRI instrument can be imaged.Present these characteristics some materials include such as tungsten, Cobalt-chromium-molybdenum alloy (for example, UNS:R44003, such as Deng), nickel-cobalt-chromium-molybdenum alloy (example Such as, UNS:R44035, such asDeng), Nitinol etc. and other materials.

In some embodiments, blood vessel plugging system 100, elongated shaft 110, cable release 120, the second cable release 122, solid Determine component 126, multiple closure medical instruments 130, fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, Three attachment mechanisms 190, microtubular 200 etc., and/or their each section can as made by polymer or other suitable materials or Include these materials.Some examples of suitable polymer can include: polytetrafluoroethylene (PTFE) (PTFE), ethylene tetrafluoroethylene copolymer (ETFE), fluorinated ethylene propylene copolymer (FEP), polyformaldehyde (POM, such as bought from DuPont)、 Polyether block ester, polyurethane (for example, Polyurethane 85A), polypropylene (PP), polyvinyl chloride (PVC), polyether ester (example Such as, it is bought from DSM Engineering Plastics company), copolymer based on ether or ester (for example, Phthalic acid butanediol/poly- (alkylene ether), and/or other polyester elastomers, as bought from DuPont), polyamide is (for example, buy from Bayer companyOr from Elf Atochem company It buys), elastomer is polyamide-based, polyamide/polyether block copolymer, polyether block amide (PEBA, Such as with product nameBuy), ethylene-vinyl acetate copolymer (EVA), polysiloxanes, polyethylene (PE), Marlex high density polyethylene (HDPE), Marlex low density polyethylene (LDPE), linear low density polyethylene (such as), polyester, Polybutylene terephthalate (PBT) (PBT), polyethylene terephthalate (PET), polypropylene terephthalate, poly- naphthalene Naphthalate (PEN), polyether-ether-ketone (PEEK), polyimides (PI), polyetherimide (PEI), polyphenylene sulfide (PPS), polyphenylene oxide (PPO), poly(p-phenylene terephthalamide) (for example,), polysulfones, nylon, Nylon-12 (such as It is bought from EMS American Grilon company), perfluoro propyl vinyl ether (PFA), ethylene-vinyl Alcohol copolymer, polyolefin, polystyrene, epoxy resin, polyvinylidene chloride (PVdC), (styrene-b-isobutylene-b- benzene second Alkene) block copolymer (for example, SIBS and/or SIBS 50A), polycarbonate-based, ionomer, polyurethane siloxane Copolymer (for example, bought from Aortech Biomaterials companyOr from AdvanSource Biomaterials company buys), biocompatible polymer, other suitable materials or they Mixture, combination, copolymer, polymer/metal composite material, etc..In some embodiments, casing and liquid crystal can be gathered Object (LCP) is closed to be mixed.For example, the mixture can contain up to about 6% LCP.In some embodiments, blood vessel seals Stifled system 100, elongated shaft 110, cable release 120, the second cable release 122, fixing component 126, multiple closure medical instruments 130, Fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, third attachment mechanism 190, microtubular 200 etc., and/or Other elements disclosed herein may include setting on this structure or internal textile material.The textile material can be by being suitble to It is constituted in biocompatible materials, above-mentioned polymer material or biomaterial long in promotion tissue.In some embodiments In, textile material may include bioabsorbable material.Some examples of suitable textile material include but is not limited to: polyethylene glycol (PEG), nylon, polytetrafluoroethylene (PTFE) (PTFE, ePTFE), polyolefine material (such as polyethylene, polypropylene), polyester, polyurethane and/ Or their blend or combination.

In some embodiments, blood vessel plugging system 100, elongated shaft 110, cable release 120, the second cable release 122, solid Determine component 126, multiple closure medical instruments 130, fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, Three attachment mechanisms 190, microtubular 200 etc. may include textile material and/or be made of textile material.Suitable textile material Some examples may include synthetic thread, these synthetic threads can be it is straight, at certain character, torsion, it is textured, It is preshrunk or not contracting.Being suitable for the invention synthesising biological compatibility silk thread includes but is not limited to: polyesters, including poly- pair Ethylene terephthalate (PET) polyesters, polyethylene kind, polyurethane, polyolefins, polyvinyls, are gathered PP type Methyl Acetates, polyamide-based, naphthalene dicarboxylic acids derivative, silk and polytetrafluoroethyl-ne alkenes.In addition, in synthetic thread at least One kind can be tinsel or glass or ceramic silk thread or fiber.Useful tinsel include by stainless steel, platinum, gold, Made by titanium, tantalum or Ni-Co-Cr based alloy or contain their silk thread.Silk thread also may include carbon fiber, glass fibre or pottery Porcelain fiber.It is desirable that silk thread is made of thermoplastic material, including but not limited to: polyesters, polyethylene kind, are gathered PP type Urethane, poly- naphthalenes, polytetrafluoroethyl-ne alkenes etc..Silk thread can belong to multifilament, monofilament or spinning type.The type and denier of selected silk thread Neil can be selected in a manner of constituting biocompatibility and implantable prosthesis, more specifically with the blood vessel of ideal performance Structure.

In some embodiments, blood vessel plugging system 100, elongated shaft 110, cable release 120, the second cable release 122, solid Determine component 126, multiple closure medical instruments 130, fixing component 140, the first attachment mechanism 170, the second attachment mechanism 180, Three attachment mechanisms 190, microtubular 200 etc. may include and/or handled with suitable therapeutic agent.The one of suitable therapeutic agent A little examples may include antithrombotic agent (such as aspirin, aspirin derivatives, urokinase and PPack (dextroamphetamine Proline acid arginine chloromethyl ketone))；(such as Enoxaparin, can prevent smooth muscle cell proliferation at angiopeptin to antiproliferative Monoclonal antibody, hirudin and acetylsalicylic acid)；Anti-inflammatory agent (such as dexamethasone, prednisolone, cortisone, budesonide, Estrogen, salicylazosulfapyridine and mesalazine)；(such as taxol, 5- fluorine urine is phonetic for antitumor/anti-proliferative/antimitotic agent Pyridine, cis-platinum, vinblastine, vincristine, Epothilones class, endostatin, angiostatin and thymidine kinase inhibit Agent)；Anesthetic (such as lidocaine, Bupivacaine and Ropivacaine)；Anticoagulant (such as D-Phe-Pro-Arg chloromethyl ketone (a kind of compound of RGD-containg peptide), aspirin, antithrombase compound, platelet receptor antagonists, antithrombase antibody, Antiplatelet receptor antibody, aspirin, prostaglandin inhibitor, platelet suppressant drug and tick antiplatelet peptides)；Blood vessel Growth promoter (such as growth factor receptor inhibitors, growth factor receptor antagonist, transcription activation factor and translation promoter)； Vascular cell growth inhibitors (such as growth factor receptor inhibitors, growth factor receptor antagonist, Transcription inhibition are sub, Translational repression is sub, Replication inhibitors, inhibiting antibody, for the antibody of growth factor, difunctional point as composed by growth factor and cytotoxin Son, the bifunctional molecule as composed by antibody and cytotoxin)；Cholesterol-lowering agent；Vasodilator；It lives with endogenous blood vessel Property mechanism interaction drug.

It should be understood that the disclosure is merely exemplary in many aspects.In the premise without departing from the scope of the present invention Under, change can be especially made in terms of the arrangement of shape, size and step in details.This may include, in suitable model In enclosing, the use of any feature of an exemplary embodiment for other embodiments.Certainly, the scope of the present invention is Term by wherein stating appended claims is limited.