一种苯并哌啶类衍生物的盐、其晶型及盐、其晶型的制备方法

文档序号:1776362 发布日期:2019-12-03 浏览:25次 >En<

阅读说明:本技术 一种苯并哌啶类衍生物的盐、其晶型及盐、其晶型的制备方法 (A kind of preparation method of the salt of benzo piperidine derivatives, its crystal form and salt, its crystal form ) 是由 尤凌峰 邵成 冯君 于 2018-06-19 设计创作,主要内容包括:公开了一种苯并哌啶类衍生物的盐、其晶型及盐、其晶型的制备方法。具体地,公开了(E)-3-(4-((1R,3R)-2-(4-环丙基苯基)-6-(1-乙基-1H-吡唑-4-基)-3-甲基-1,2,3,4-四氢异喹啉-1-基)苯基)丙烯酸的L-赖氨酸盐、其I晶型及其制备方法。式(I)化合物、其I晶型具备良好的稳定性、工艺简单易于操作,可更好地用于临床治疗。&lt;Image he="340" wi="557" file="DDA0002240959120000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"&gt;&lt;/Image&gt;(Disclose a kind of salt of benzo piperidine derivatives, the preparation method of its crystal form and salt, its crystal form.Specifically, disclose (E) -3- (4- ((1R, 3R) -2- (4- cyclopropyl phenyl) -6- (1- ethyl -1H- pyrazoles -4- base) -3- methyl-1,2,3,4- tetrahydroisoquinoline -1- bases) phenyl) the L-lysine salt of acrylic acid, its I crystal and preparation method thereof.It is easily operated that formula (I) compound, its I crystal have good stability, a simple process, can be preferably applied to clinical treatment.)

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