阅读说明：本技术 一种多功能分析仪器 (Multifunctional analysis instrument ) 是由 罗进才 黄江航 于 2019-09-30 设计创作，主要内容包括：本发明涉及分析检测技术领域,尤其公开了一种多功能分析仪器,包括机架,机架设有支撑平台,支撑平台设有容置孔,盛放待测样本的容器件位于容置孔内或者遮盖容置孔；机架或/和支撑平台设置有观测件及光源件,容器件采用透光材料制成,光源件可发射单色光或/和复色光,观测件用于显微成像或/和光强感应；在多功能分析仪器的使用过程中,先将待测样本注入容器件内,然后将容器件装入容置孔内,而后再利用光源件发出的光线照射容器件内的待测样本,之后再利用观测件显微成像或/和光强感应,通过对显微成像所获得的图像,可实现对待测样本中有形成份的自动检测,通过光强感应的检测可实现对待测样本中特定物质浓度的分析。(The invention relates to the technical field of analysis and detection, and particularly discloses a multifunctional analysis instrument which comprises a rack, wherein the rack is provided with a supporting platform, the supporting platform is provided with a containing hole, and a container part for containing a sample to be detected is positioned in the containing hole or covers the containing hole; the rack or/and the supporting platform are/is provided with an observation piece and a light source piece, the container piece is made of a light-transmitting material, the light source piece can emit monochromatic light or/and polychromatic light, and the observation piece is used for microscopic imaging or/and light intensity induction; in the use process of the multifunctional analysis instrument, a sample to be detected is injected into the container part, then the container part is arranged in the accommodating hole, then the light emitted by the light source part is utilized to irradiate the sample to be detected in the container part, then the observation part is utilized to carry out microscopic imaging or/and light intensity induction, the automatic detection of the shape component in the sample to be detected can be realized through the image obtained by the microscopic imaging, and the analysis of the concentration of the specific substance in the sample to be detected can be realized through the detection of the light intensity induction.)

1. A multifunctional analysis instrument is characterized in that: the device comprises a rack, wherein the rack is provided with a supporting platform, the supporting platform is provided with a containing hole penetrating through the supporting platform, and a container piece for containing a sample to be detected is positioned in the containing hole or covers the containing hole; the rack or/and the supporting platform are/is provided with an observation piece and a light source piece, the light source piece and the observation piece are respectively positioned on two sides of the container piece, the container piece is made of a light-transmitting material, the light source piece can emit monochromatic light or/and polychromatic light, light emitted by the light source piece is used for irradiating a sample to be detected in the container piece, and the observation piece is used for microscopic imaging or/and light intensity induction.

2. The multifunctional analysis instrument of claim 1, wherein: the observation piece also comprises a camera unit and a microscope unit, wherein the microscope unit is used for carrying out microscopic camera shooting on tangible components in the sample to be detected irradiated by the light source piece, and the camera unit is used for converting an optical image of the sample to be detected observed by the microscope unit into a digital signal.

3. The multifunctional analysis instrument of claim 1, wherein: the monochromatic light or/and the polychromatic light emitted by the light source component irradiates a sample to be detected in the container component, and the observation component is used for performing photoelectric conversion on an optical signal penetrating through the sample to be detected.

4. The multifunctional analysis instrument of claim 1, wherein: the light source part and the observation part are respectively positioned on the upper side, the lower side, the left side, the right side or the front side and the rear side of the container part, the container part is arranged along a connecting line of the light source part and the observation part, and the container part is arranged in a light-transmitting manner along the connecting line between the light source part and the observation part.

5. The multifunctional analysis instrument of claim 1, wherein: the container piece is provided with a plurality of accommodating cavities, the accommodating cavities are used for accommodating samples to be detected, and the accommodating cavities are arranged in a direction perpendicular to the central axis of the accommodating hole.

6. The multifunctional analysis instrument of claim 1, wherein: the supporting platform is provided with a guide rail above, the guide rail is provided with a sliding block in a sliding mode, the light source piece is arranged on the sliding block, and the light source piece is located above the container piece.

7. The multifunctional analysis instrument of claim 1, wherein: the frame or/and the supporting platform are/is provided with a lifting moving mechanism, the observation piece or the container piece is arranged at the output end of the lifting moving mechanism, and the lifting moving mechanism is used for driving the observation piece or the container piece to approach or leave along the vertical direction.

8. The multifunctional analysis instrument of claim 1, wherein: the rack or/and the supporting platform are/is provided with a horizontal moving mechanism, the observation piece or the container piece is arranged at the output end of the horizontal moving mechanism, and the horizontal moving mechanism is used for driving the observation piece or the container piece to move along the horizontal direction.

9. The multifunctional analysis instrument of claim 1, wherein: the supporting platform is provided with a sliding groove, a supporting plate is arranged in the sliding groove in a sliding mode, the rack or/and the supporting platform are/is provided with a driving mechanism, the driving mechanism is used for driving the supporting plate to move back and forth along the length direction of the sliding groove, and the containing holes are formed in the supporting plate.

10. The multifunctional analysis instrument of claim 9, wherein: the supporting plate is provided with two abdicating grooves which are concavely arranged from the top surface of the supporting plate, and the two abdicating grooves are respectively positioned at two sides of the accommodating hole; the container member is provided with an accommodating part and a base part connected with the accommodating part, the outer diameter of the base part is larger than that of the accommodating part, the accommodating part is accommodated in the accommodating hole, and the top surface of the supporting plate is used for abutting against and stopping one end of the base part close to the accommodating part.

Technical Field

The invention relates to the technical field of analysis and detection, and particularly discloses a multifunctional analysis instrument.

background

The analysis and detection of the concentration of a tangible component and a content in a sample such as blood or body fluid of a human or an animal is a medically very important and routine examination item. The detection of the visible components in the blood includes the detection of parameters such as the number, size and shape of red blood cells, white blood cells and platelets in the blood. The detection of the content in blood includes the detection of hemoglobin concentration, C-reactive protein concentration, and the like. The body fluid comprises urine, cerebrospinal fluid, hydrothorax, ascites, feces and the like, the visible components in the body fluid comprise red blood cells, white blood cells, casts, crystals, microorganisms and the like, and the detection of the contents in the body fluid comprises protein concentration, chloride content and the like.

In the field of detection of visible components in blood, a Boehringer's counter method, a Coulter resistance method, a centrifugation method, a microfluidic method and the like are used traditionally. The Bowden counting plate method is extremely complicated in operation, extremely low in working efficiency, few in parameters, poor in performance, and needs to be operated by professional personnel, and is basically eliminated. The coulter method is the mainstream method, has accurate result and high working efficiency, but has the defects of large instrument volume, high price, large reagent package, 24-hour startup and inapplicability to primary hospitals with small sample size. The centrifugal cell analysis instrument is convenient to carry, does not need liquid reagents, is convenient to use in the field, but has inaccurate results, is only used for preliminary screening of war and disaster sites, and cannot meet the requirements of clinical diagnosis. The microfluidic method integrates a liquid path and an analysis circuit required by a cell counter based on the Coulter principle on a microchip, so as to achieve the purpose of simplifying the structure of the instrument, but the technology has complex process and high cost. In the field of detection of body fluid visible components, currently, an artificial microscopic method is mostly adopted, professional personnel need to observe and judge under a microscope, the efficiency is low, and an analysis instrument capable of simultaneously detecting body fluid visible components and contents is absent at present.

However, in the vast primary medical institutions (rural health centers, private clinics, primary communities, hospital bedside, emergency treatment sites, animal clinics, etc.), due to the fact that many medical examiners are non-professional, the number of detected samples is small, the site and the cost are limited, and the like, a multifunctional analyzer which is small in size, easy and convenient to operate, and fast in reporting, and can meet the detection requirements of contents such as blood and body fluid visible components and hemoglobin concentration is urgently needed.

Disclosure of Invention

In order to overcome the defects and shortcomings in the prior art, the invention aims to provide a multifunctional analysis instrument which can detect and analyze visible components and contents in samples such as blood or body fluid.

In order to achieve the purpose, the multifunctional analysis instrument comprises a rack, wherein the rack is provided with a supporting platform, the supporting platform is provided with a containing hole penetrating through the supporting platform, and a container part for containing a sample to be detected is positioned in the containing hole or covers the containing hole; the rack or/and the supporting platform are/is provided with an observation piece and a light source piece, the light source piece and the observation piece are respectively positioned on two sides of the container piece, the container piece is made of a light-transmitting material, the light source piece can emit monochromatic light or/and polychromatic light, light emitted by the light source piece is used for irradiating a sample to be detected in the container piece, and the observation piece is used for microscopic imaging or/and light intensity induction.

Preferably, the monochromatic light or/and the polychromatic light emitted by the light source device illuminates a sample to be measured in the container device, the observation device further comprises a camera unit and a microscope unit, the microscope unit is used for performing microscopic camera shooting on tangible components in the sample to be measured illuminated by the light source device, and the camera unit is used for converting an optical image of the sample to be measured observed by the microscope unit into a digital signal.

preferably, the monochromatic light or/and the polychromatic light emitted by the light source device irradiates the sample to be measured in the container device, and the observation device is used for performing photoelectric conversion on the optical signal after penetrating through the sample to be measured.

Preferably, the light source part and the observation part are respectively positioned at the upper side, the lower side, the left side, the right side or the front side and the rear side of the container part, the container part is arranged along a connecting line of the light source part and the observation part, and the container part is arranged in a light-transmitting way along the connecting line between the light source part and the observation part.

Preferably, the container member is provided with a plurality of accommodating cavities, the accommodating cavities are used for accommodating samples to be tested, and the accommodating cavities are arranged in a direction perpendicular to the central axis of the accommodating hole.

Preferably, a guide rail is arranged above the supporting platform, a sliding block is arranged on the guide rail in a sliding manner, the light source part is arranged on the sliding block, and the light source part is positioned above the container part.

Preferably, the rack or/and the supporting platform is/are provided with a lifting and moving mechanism, the observation piece or the container piece is/are arranged at the output end of the lifting and moving mechanism, and the lifting and moving mechanism is used for driving the observation piece or the container piece to approach or move away from the observation piece or the container piece in the vertical direction.

Preferably, the rack or/and the supporting platform is/are provided with a horizontal moving mechanism, the observation piece or the container piece is/are arranged at the output end of the horizontal moving mechanism, and the horizontal moving mechanism is used for driving the observation piece or the container piece to move along the horizontal direction.

Preferably, the supporting platform is provided with a sliding groove, a supporting plate is slidably arranged in the sliding groove, the rack or/and the supporting platform is/are provided with a driving mechanism, the driving mechanism is used for driving the supporting plate to move back and forth along the length direction of the sliding groove, and the accommodating hole is formed in the supporting plate.

Preferably, the supporting plate is provided with two abdicating grooves which are concavely arranged from the top surface of the supporting plate, and the two abdicating grooves are respectively positioned at two sides of the accommodating hole; the container member is provided with an accommodating part and a base part connected with the accommodating part, the outer diameter of the base part is larger than that of the accommodating part, the accommodating part is accommodated in the accommodating hole, and the top surface of the supporting plate is used for abutting against and stopping one end of the base part close to the accommodating part.

The invention has the beneficial effects that: during the use of the multifunctional analysis instrument, a sample to be detected is injected into the container part, then the container part is arranged in the accommodating hole, then the light emitted by the light source part is utilized to irradiate the sample to be detected in the container part, and then the observation part is utilized to carry out microscopic imaging or/and light intensity induction, so that the analysis and detection of the sample to be detected are realized; according to different analysis requirements, a user can change the frequency of the light emitted by the light source part to meet different analysis requirements.

Drawings

FIG. 1 is a schematic perspective view of the present invention;

FIG. 2 is an exploded view of the present invention;

FIG. 3 is a schematic structural view of a first embodiment of a containment member of the present invention;

Fig. 4 is a schematic structural view of a second embodiment of the containment member of the present invention.

The reference numerals include:

1-frame 2-supporting platform 3-containing hole

4-container 5-light source 6-observation unit

7-microscope unit 8-camera unit 9-guide

11-slide block 12-lifting moving mechanism 13-horizontal moving mechanism

14-chute 15-supporting plate 16-abdicating groove

17-housing 18-base 19-drive mechanism.

Detailed Description

for the understanding of those skilled in the art, the present invention will be further described with reference to the following examples and drawings, which are not intended to limit the present invention.

Referring to fig. 1 and 2, the multifunctional analyzer of the present invention includes a frame 1, the frame 1 is made of a metal material, a supporting platform 2 is installed at a top end of the frame 1, the supporting platform 2 is substantially in a rectangular flat plate shape, a containing hole 3 penetrating through the supporting platform 2 is formed in the supporting platform 2, the containing hole 3 penetrates through the supporting platform 2 in a vertical direction, and a container member 4 containing a sample to be detected is located in the containing hole 3 or the container member 4 containing the sample to be detected covers the containing hole 3.

An observation piece 6 and a light source piece 5 are arranged on the frame 1 or/and the supporting platform 2, the light source piece 5 and the observation piece 6 are respectively positioned at two sides of the container piece 4, the container piece 4 is made of a light-transmitting material, the light source piece 5 can emit monochromatic light or/and polychromatic light, the monochromatic light or/and polychromatic light emitted by the light source piece 5 is used for illuminating a sample to be detected in the container piece 4, and the observation piece 6 is used for microscopic imaging or/and light intensity induction, so that the sample to be detected can be analyzed.

When observation piece 6 is used for the light intensity to respond to, observation piece 6 is used for receiving the light intensity after penetrating the sample that awaits measuring, and observation piece 6 is used for carrying out photoelectric conversion to the light signal after seeing through the sample that awaits measuring, and the control system analysis light intensity that light source 5 sent and the light intensity that observation piece 6 received via multi-functional analytical instrument, and then carries out detection and analysis to specific material concentration in the sample that awaits measuring.

When the observation piece 6 is used for microscopic imaging, a sample to be detected is injected into the container piece 4, then the container piece 4 is loaded into the containing hole 3 or covered on the containing hole 3, then the sample to be detected in the container piece 4 is irradiated by light rays emitted by the light source piece 5, then the sample to be detected irradiated by the light source piece 5 is observed by the observation piece 6, and the observation piece 6 carries out microscopic imaging on visible components in the sample to be detected after the light source piece 5 illuminates, so that the analysis and detection of the visible components in the sample to be detected are realized.

For example, after a sample to be tested containing red blood cells is injected into the container member 4, the red blood cells are settled on the inner wall of the cavity bottom of the container member 4 through natural settling or centrifugal treatment, the horizontal moving mechanism 13 drives the observation member 6 to move horizontally, the driving mechanism 19 drives the supporting plate 15 to drive the container member 4 to move along the length direction of the sliding chute 14, so that the container member 4 is positioned on a connecting line between the light source member 5 and the observation member 6, the light source member 5 emits monochromatic light and/or polychromatic light to illuminate the red blood cells in the container member 4, the lifting moving mechanism 12 drives the microscope unit 7 of the container member 4 or the observation member 6 to move to realize the approaching or separating of the microscope unit 7 and the container member 4 along the vertical direction, thus, the micro focusing is completed, and the imaging unit 8 of the observation piece 6 converts the observed optical image of the sample to be measured into a digital signal after the focusing is completed. The microscope unit 7 repeats the above operations for different areas of the inner wall of the cavity bottom of the container member 4, and the control system of the analyzer splices and identifies the obtained images, thereby realizing the analysis of the characteristics of the number, the shape, the size and the like of the red blood cells in the container member 4.

When detecting the visible components such as white blood cells, platelets, casts, crystals, microorganisms and the like in the sample to be detected, different diluents or treatment methods can be adopted to settle the visible components on the inner wall of the cavity bottom of the container 4, and the multifunctional analyzer completes the detection and analysis of the visible components by adopting the method for detecting red blood cells.

When the hemoglobin concentration in blood (sample to be detected) needs to be detected, the blood sample to be detected is injected into the container member 4, hemolysin is injected into the container member 4 in advance, and the blood sample to be detected reacts with the hemolysin to crack red blood cells in the blood to form a hemoglobin solution. The driving mechanism 19 drives the supporting plate 15 to drive the container part 4 to move along the length direction of the sliding chute 14, so that the container part 4 is positioned on a connecting line between the light source part 5 and the observation part 6, at the moment, the light source part 5 emits monochromatic light and/or polychromatic light to illuminate the hemoglobin solution in the container part 4, and the observation part 6 performs photoelectric conversion on a light signal which penetrates through the hemoglobin solution.

When the concentration of substances such as C-reactive protein, blood sugar and the like in blood needs to be detected, corresponding reaction reagents or treatment liquid are embedded in the container part 4 in advance, and the multifunctional analysis instrument adopts the method for detecting the concentration of hemoglobin to complete the detection and analysis of the concentration of the substances.

Preferably, the observation member 6 includes a photocell installed on the frame 1, the photocell is a semiconductor element generating electromotive force under the irradiation of light, the light emitted from the light source member 5 penetrates through the sample to be measured and irradiates on the photocell, and the photocell performs photoelectric conversion, thereby realizing the concentration detection of the sample to be measured.

In this embodiment, the observation device 6 further includes a microscope unit 7 and an image capturing unit 8 (e.g., an industrial camera, etc.), and preferably, the light source device 5 is located above the container device 4, the observation device 6 is located below the container device 4, the image capturing unit 8 is configured to capture an image of the sample to be measured amplified by the microscope unit 7, and the image capturing unit 8 is configured to convert an optical image of the sample to be measured observed by the microscope unit 7 into a digital signal. After the microscope unit 7 observes the sample to be measured irradiated by the light source device 5, the image pickup unit 8 picks up an image of the sample to be measured amplified by the microscope unit 7, transmits the picked-up image to a control system of an analyzer for splicing and identification, and finally displays the image through an external display unit (such as a display screen) so as to be convenient for a user to recognize and watch the image.

The container part 4 is arranged in a light-transmitting mode along the central axis direction of the containing hole 3, the light source part 5 and the observation part 6 are respectively positioned on the upper side, the lower side, the left side, the right side or the front side and the rear side of the container part 4, the container part 4 is arranged along a connecting line of the light source part 5 and the observation part 6, the container part 4, the light source part 5 and the observation part 6 are arranged in a collinear mode, and the container part 4 is arranged in a light-transmitting mode along the connecting line between the light source part 5 and.

The container piece 4 is provided with a plurality of holding cavities, the holding cavities are respectively used for holding samples to be tested, and the holding cavities are arranged in the direction perpendicular to the central axis of the holding hole 3, namely the holding cavities are arranged in sequence in the horizontal direction. During actual use, the samples to be detected in the accommodating cavities are respectively used for analyzing different parameters of the samples to be detected.

The upper portion of the supporting platform 2 is provided with a guide rail 9, the guide rail 9 is approximately in a straight strip shape, a sliding block 11 is arranged on the guide rail 9 in a sliding mode, the light source part 5 is arranged on the sliding block 11, and the light source part 5 is located above the container part 4. During the use of the multifunctional analysis instrument, a user can move the light source piece 5 by moving the sliding block 11, so as to change the relative position between the light source piece 5 and the accommodating cavity.

The slide block 11 may further be provided with a rotating carrier plate, a rotation axis between the carrier plate and the slide block 11 is parallel to the guide rail 9, in this embodiment, the carrier plate may be pivotally connected to the slide block 11 via a pivot, the rotation axis between the carrier plate and the slide block 11 is parallel to a horizontal plane, and the light source device 5 is mounted on the carrier block 22. In practice, the user can rotate the light source 5 by rotating the carrier plate.

The lifting and moving mechanism 12 is installed on the frame 1 or/and the supporting platform 2, the lifting and moving mechanism 12 is the prior art, and is not described herein any more, the observation piece 6 or the container piece 4 is arranged at the output end of the lifting and moving mechanism 12, the lifting and moving mechanism 12 is used for driving the observation piece 6 and the container piece 4 to be close to or far away from each other, and the lifting and moving mechanism 12 is used for driving the observation piece 6 and the container piece 4 to be close to or far away from each other along the vertical direction. According to actual needs, the observation piece 6 is driven to be close to or far away from the container piece 4 through the lifting and moving mechanism 12, and then the observation piece 6 can observe a high-definition image of the sample to be detected.

A horizontal moving mechanism 13 is installed on the frame 1 or/and the supporting platform 2, the horizontal moving mechanism 13 is a prior art, and is not described herein again, the lifting moving mechanism 12 is disposed at an output end of the horizontal moving mechanism 13, and the horizontal moving mechanism 13 drives the microscope unit 7 to move parallel to the container member 4 via the lifting moving mechanism 12. The horizontal moving mechanism 13 drives the lifting moving mechanism 12 to move horizontally, the lifting moving mechanism 12 which moves horizontally drives the microscope unit 7 to move horizontally, and then the position of the microscope unit 7 relative to the container 4 is finely adjusted, so that the microscope unit 7 observes images of different areas in the container 4.

Of course, according to actual needs, the observation member 6 or/and the container member 4 may be disposed on the horizontal moving mechanism 13, and the horizontal moving mechanism 13 is used for driving the observation member 6 or/and the container member 4 to move along the horizontal direction, so as to ensure that the observation member 6 can accurately observe images of different areas in the container member 4. Of course, according to actual needs, the light source device 5 mounted on the rack 1 may be a monochromatic LED, and the observation device 6 mounted on the rack 1 may be a photocell, preferably, the light source device 5 and the observation device 6 are respectively located at the left and right sides of the container device 4, light emitted by the light source device 5 penetrates through a sample to be measured in the container device 4 and then irradiates the photocell, and when the device is used, the light source device 5 emits monochromatic light which irradiates the sample to be measured in the container device 4 and penetrates through the container device 4 and then irradiates the photocell.

Supporting platform 2 is last to be provided with spout 14, and spout 14 is established from supporting platform 2's top surface is concave to form, and spout 14 runs through supporting platform 2, and the slip is held in spout 14 and is equipped with layer board 15, and the installation is equipped with actuating mechanism 19 on frame 1 or/and supporting platform 2, and actuating mechanism 19 is prior art, and no longer gives unnecessary details here, and actuating mechanism 19 is used for driving layer board 15 along the length direction round trip movement of spout 14, holds the setting of hole 3 on layer board 15. The driving mechanism 19 drives the supporting plate 15 to move back and forth along the length direction of the sliding chute 14, and the horizontal moving mechanism 13 drives the observation member 6 to move along the horizontal direction, so that the microscope unit 7 of the observation member 6 can observe all regions of the container member 4 to be observed.

In the use of multi-functional analytical instrument, according to actual need, can drive the relative supporting platform 2 of layer board 15 through actuating mechanism 19 and remove, and layer board 15 moves together along with container spare 4 when removing, and then adjusts the position of container spare 4, ensures that the light that light source spare 5 sent can accurately shine the sample that awaits measuring in the container spare 4.

The supporting plate 15 is provided with two abdicating grooves 16, the abdicating grooves 16 are concavely formed from the top surface of the supporting plate 15, and the two abdicating grooves 16 are respectively positioned at the left side and the right side of the accommodating hole 3; when in use, a user holds the container part 4 with the forefinger and the thumb, and then puts the container part 4 communicated with a sample to be measured into the containing hole 3. When the container part 4 needs to be removed, the forefinger and the thumb respectively enter the two abdicating grooves 16, then the container part 4 is pinched by the forefinger and the thumb, then the container part 4 is pulled out of the containing hole 3, and then the container part 4 which is subjected to analysis detection in the containing hole 3 can be removed.

The container member 4 is provided with an accommodating part 17 and a base part 18 connected with the accommodating part 17, the outer diameter of the base part 18 is larger than that of the accommodating part 17, the accommodating part 17 is accommodated in the accommodating hole 3, the inner hole wall of the accommodating hole 3 is abutted against and stops the accommodating part 17, and the container member 4 is prevented from shaking back and forth in the accommodating hole 3; of course, the user may replace different pallets 15 according to the outer diameter of the accommodating portion 17 of different container members 4, so that different pallets 15 may restrain container members 4 of various sizes. After the accommodating portion 17 is received in the accommodating hole 3, the top surface of the supporting plate 15 is used to stop the end of the base portion 18 close to the accommodating portion 17, so as to prevent the container 4 from falling through the accommodating hole 3, and ensure that the container 4 is stably positioned on the supporting platform 2.

The above description is only a preferred embodiment of the present invention, and for those skilled in the art, the present invention should not be limited by the description of the present invention, which should be interpreted as a limitation.