阅读说明：本技术 用于个体化治疗管理的疾病活动性表征方法 (Disease activity characterization method for personalized therapy management ) 是由 S·辛格 N·霍 S·洛克腾 S·豪恩施泰因 L·奥尔穆德 于 2012-05-10 设计创作，主要内容包括：本发明提供了用于个体化治疗管理疾病,从而优化疗法和/或监控疗效的方法。特别的是,本发明包括在用治疗剂的治疗过程的多个时间点,测量一个或多个生物标志物的阵列,确定用于选择疗法、优化疗法、降低毒性和/或监控治疗性治疗的功效的粘膜愈合指数。在某些情况下,治疗剂是用于治疗TNFα-介导的疾病或病症的TNFα抑制剂。(the present invention provides methods for personalized treatment management of diseases, thereby optimizing therapy and/or monitoring efficacy. In particular, the invention includes measuring an array of one or more biomarkers at multiple time points during a treatment with a therapeutic agent to determine a mucosal healing index for selecting a therapy, optimizing the therapy, reducing toxicity, and/or monitoring the efficacy of the therapeutic treatment. In certain instances, the therapeutic agent is a TNF α inhibitor for treating a TNF α -mediated disease or disorder.)