阅读说明：本技术 肌肤暗沉抑制剂及肌肤屏障功能维持或改善剂 (Skin dullness inhibitor and agent for maintaining or improving skin barrier function ) 是由 杉本和久 三瓶春代 于 2018-05-15 设计创作，主要内容包括：本发明提供一种具有对肌肤暗沉的效果及对肌肤屏障功能降低的效果的含有源自植物的成分的新型试剂。一种肌肤暗沉抑制剂或肌肤屏障功能维持或改善剂,其含有红辣椒的油溶性提取物。肌肤暗沉抑制剂或肌肤屏障功能维持或改善剂优选为口服剂,油溶性提取物优选含有己烷可溶成分。(The present invention provides a novel agent containing a plant-derived component, which has an effect on skin dullness and an effect on reduction of skin barrier function. A skin dullness inhibitor or a skin barrier function maintaining or improving agent contains an oil-soluble extract of red pepper. The skin dullness inhibitor or the skin barrier function maintaining or improving agent is preferably an oral agent, and the oil-soluble extract preferably contains a hexane-soluble component.)

1. A skin dullness inhibitor contains oil-soluble extract of red pepper.

2. The skin dullness inhibitor according to claim 1, which is an oral agent.

3. The skin dullness inhibitor according to claim 1 or 2, wherein the oil-soluble extract contains a hexane-soluble component.

4. A skin barrier function maintaining or improving agent contains oil-soluble extract of red pepper.

5. The skin barrier function maintaining or improving agent according to claim 4, which is an oral agent.

6. The skin barrier function maintaining or improving agent according to claim 4 or 5, wherein the oil-soluble extract contains a hexane-soluble component.

7. Application of oil soluble extract of Capsici fructus in preparing skin darkness inhibitor is provided.

8. Use of oil-soluble extract of red pepper in the manufacture of a skin barrier function maintaining or improving agent.

Technical Field

The present invention relates to a skin dullness inhibitor and a skin barrier function maintaining or improving agent. More particularly, the present invention relates to a skin dullness inhibitor and a skin barrier function maintaining or improving agent containing a red pepper extract.

Background

The dullness of the skin is a phenomenon that occurs in the skin with age, and is thought to occur due to a complex involvement of main causes such as a shadow or shadow due to thickening of the horny layer, a decrease in redness of the skin, and an increase in yellowing of the skin. A decrease in lightness was observed in the skin that developed dullness.

As a skin color improving agent for improving skin dullness, patent document 1 describes an oral preparation containing crocetin or a pharmacologically acceptable salt thereof as an active ingredient. Crocetin as an active ingredient of the oral preparation can be obtained by extracting dried fruits of gardenia jasminoides with a mixture of ethanol and water, for example.

Further, the decrease in skin barrier function is also a phenomenon that is likely to occur in skin having various skin diseases or aged muscles, and is thought to occur due to, for example, a structural or compositional failure for the stratum corneum to function as a barrier. An increase in the transdermal evaporation of water contained in the bottom layer of the stratum corneum is observed in skin with reduced skin barrier function.

As a skin barrier function-promoting agent, patent document 2 describes an external preparation containing astaxanthin and one or both of tocopherol and a glyceride having a specific structure. The astaxanthin in the external preparation can be obtained in the form of, for example, Haematococcus extract.

As described above, various attempts have been made to utilize natural ingredients derived from plants as active ingredients of cosmetics. On the other hand, cosmetics using components derived from capsicum (capsicum annum L.) are also known.

For example, patent document 3 discloses a fermented composition containing a fermented product of capsicum or a plant containing capsinoid (capsinoid) or an extract thereof. It is described that the fermentation composition is preferably a fermentation product of capsicum annuum of a non-pungent variety such as CH-19 pimento, and is used as an anti-fatigue agent, a physical strength enhancer, an anti-obesity agent, an antioxidant, a skin-beautifying agent, a whitening agent, and a flavor improving agent.

Patent document 4 describes a cosmetic composition containing steam distilled water of 1 or more plants selected from capsicum and the like belonging to solanaceae plants. Specifically, the cosmetic composition is described as improving dry skin and imparting gloss and elasticity to the skin.

Patent document 5 describes a whitening cosmetic composition containing at least one of an extract of agaric belonging to the family of agaric, an extract of behenic belonging to the family of cruciferae, an extract of capsicum annuum belonging to the family of solanaceae, and an extract of buckwheat belonging to the family of polygonaceae as an active ingredient. In the cosmetic composition for whitening skin, the extract of Capsici fructus of Solanaceae is obtained from Capsici fructus used in spices, specifically green Capsici fructus.

Disclosure of Invention

Technical problem to be solved by the invention

In the fermented composition of patent document 3, by subjecting the raw material to fermentation treatment, the pungent taste and irritation of capsaicin are reduced, and amino acids and vitamins are enhanced. Furthermore, as described in comparative examples 1 and 2 and the like of patent document 3, the desired effects cannot be obtained with the composition that is not subjected to the fermentation treatment. In addition, patent document 3 shows that CH-19 sweet peppers, which are effective raw materials, are 1 kind of blue non-pungent peppers.

The cosmetic composition of patent document 4 contains steam distilled water of capsicum, and therefore, the active ingredient thereof is a water-soluble ingredient among ingredients derived from capsicum. In addition, in the cosmetic composition, it is not possible to specify which of the pungent pepper and the non-pungent pepper, or which of the red pepper and the blue pepper is the pepper.

In the whitening cosmetic composition of patent document 5, an effective component for the whitening effect is an extract of blue pungent pepper.

As described in patent documents 3 to 5, the effect of a component derived from green pepper, a water-soluble component and/or a component subjected to a fermentation treatment among components derived from pepper on the skin was actually confirmed. The components derived from capsicum vary greatly in composition depending on the kind of capsicum, the extraction solvent, the presence or absence of fermentation treatment, and the like. There is no report that the ingredients other than the above-mentioned ingredients among the ingredients derived from capsicum are cosmetically verified, and the effects on dullness and the skin barrier function as described in patent documents 1 and 2 cannot be inferred for the ingredients other than the above-mentioned ingredients.

Accordingly, a main object of the present invention is to provide a novel agent containing a plant-derived component, which has an effect on skin dullness and an effect on skin barrier function.

Means for solving the problems

The inventors of the present invention have conducted extensive studies and found that: the oil-soluble extract of red pepper has the effects of dullness and barrier function to skin. The present invention has been completed through further repeated studies based on this finding.

That is, the present invention provides the following embodiments.

Item 1. a skin dullness inhibitor, which contains an oil-soluble extract of red pepper.

The skin dullness inhibitor according to item 1, which is an oral agent.

Item 3 the skin dullness inhibitor according to item 1 or 2, wherein the oil-soluble extract contains a hexane-soluble component.

Item 4. a skin barrier function maintaining or improving agent containing an oil-soluble extract of red pepper.

The skin barrier function maintaining or improving agent according to the item 4, which is an oral agent.

Item 6 the skin barrier function maintaining or improving agent according to item 4 or 5, wherein the oil-soluble extract contains a hexane-soluble component.

Item 7. use of oil-soluble extract of red pepper in the manufacture of skin dullness inhibitor.

Item 8. use of an oil-soluble extract of red pepper in the manufacture of a skin barrier function maintaining or improving agent.

Effects of the invention

According to the present invention, there is provided a novel agent containing a plant-derived component, which has an effect on skin dullness and an effect on skin barrier function.

Detailed Description

[1. inhibition of skin darkening ]

In the skin dullness inhibitor of the present invention, skin dullness (hereinafter abbreviated as dullness) is a skin state in which the lightness of skin color is reduced. Dullness is caused by thickening of the horny layer, peeling of the horny layer, reduction of elasticity of the skin, reduction of reddening of the skin color, increase of yellowing of the skin color, and the like, and the mechanism of action thereof is different from pigmentation caused by stimulation of melanocytes.

In the skin with a dull appearance, skin phenomena such as a decrease in skin transparency (cloudiness), a decrease in skin luster (dark shadows), and deposition of dirt such as sweat and sebum are observed. Examples of the cause of the occurrence of darkness include age increase, environmental changes (temperature fluctuation, humidity decrease, and the like), and these causes may affect each other. The effect of suppressing the darkening due to the darkening inhibitor of the present invention is preferably and easily exerted on skin of an aged person (for example, over 40 years) when the environment is changed.

Dullness can be evaluated from skin lightness (L value). When the darkness is improved, the skin brightness tends to be increased. The term "suppression of dullness" means an effect of counteracting the progress of dullness, and includes, for example, not only an effect of increasing skin brightness but also an effect of reducing the degree of decrease in skin brightness caused by the occurrence of dullness and an effect of maintaining skin brightness.

[2. maintenance or improvement of skin barrier function ]

In the skin barrier function maintaining or improving agent of the present invention, the skin barrier function refers to a function caused by, for example, the adhesion state of keratinocytes in the stratum corneum to lipids between the keratinocytes. The skin phenomenon in which the skin barrier function is reduced is caused by disorder in arrangement of keratinocytes due to poor adhesion of the keratinocytes to intercellular lipids of the keratinocytes, and the like, and the action mechanism thereof is different from reduction in proliferation function of fibroblasts and also different from temporary inflammation caused by sunburn.

In the skin having a decreased skin barrier function, the water content from the bottom layer of the stratum corneum is lost, and sensitivity to external irritation is increased, and skin phenomena such as rough skin, rash, and itching are observed. The factors that cause the reduction in skin barrier function include age increase, environmental changes (temperature fluctuation, humidity reduction, etc.), mental stress, environmental pollutants, and the like, and these factors may affect each other. The skin barrier function maintaining or improving effect of the skin barrier function maintaining or improving agent of the present invention is preferable and easily effective for the skin which is a main cause of the reduction of the skin barrier function, particularly, the sensitive skin of the middle aged (for example, 30 to 40 years old).

Skin barrier function can be evaluated according to the amount of percutaneous water loss (TEWL). When the skin barrier function is lowered, the amount of percutaneous water loss tends to increase, and when the skin barrier function is improved, the amount of percutaneous water loss tends to decrease. The maintenance or improvement of the skin barrier function means an effect of not lowering the skin barrier function, and includes, for example, not only an effect of reducing the amount of the percutaneous water loss but also an effect of reducing the degree of increase in the amount of the percutaneous water loss due to a factor causing the lowering of the skin barrier function and an effect of maintaining the amount of the percutaneous water loss.

[3. Red pepper extract ]

The darkness inhibitor and the skin barrier function maintaining or improving agent of the present invention contain an oil-soluble extract of red pepper as an active ingredient. The red pepper extract is an extract obtained by subjecting red pepper to an extraction treatment.

[3-1. raw materials ]

The red pepper is a plant of Capsicum (Capsicum) of Solanaceae (Solanaceae). Specifically, there may be mentioned Capsicum annuum, more specifically, there may be mentioned Capsicum annuum l, and still more specifically, there may be mentioned Capsicum annuum l. Furthermore, red pepper is red peppery-free pepper among the above plants. The variety and the producing area of red pepper are not particularly limited. Examples thereof include bell-type peppers, Ramyro (ラ ミ ュ ー ロ) type peppers, and wedge-type peppers (e.g., Barlem). In view of the production efficiency of the extract, a variety having a small water content (e.g., capsicum sphenoides such as Barlem) is preferable.

The part from which the red pepper is extracted is not particularly limited as long as it contains at least the flesh. Examples of other sites allowable for the extraction site include seeds, flowers, stems, leaves, and rhizomes. From the viewpoint of preferably obtaining the darkness-suppressing ability and the skin barrier function maintaining or improving ability, the extraction site is preferably a site substantially only of the flesh. In the production of the extract, the extracted part of the red pepper may be used as it is, or may be used in a state of being subjected to a pretreatment such as pulverization or fine cutting in advance, or pulverization or fine cutting after drying.

[3-2. extraction ]

The extraction method is not particularly limited, except that an organic solvent is used as the extraction solvent. The organic solvent may be an apolar solvent, a polar aprotic solvent, or a polar protic solvent. Examples of the nonpolar solvent include: hydrocarbon solvents such as hexane (n-hexane, cyclohexane, etc.), toluene, preferably hexane (n-hexane, cyclohexane, etc.), particularly preferably n-hexane; ether solvents such as dimethyl ether and diethyl ether; halogenated hydrocarbon solvents such as chloroform, dichloromethane, and trichloroethylene; and ester solvents such as ethyl acetate. Examples of the polar aprotic solvent include ketone solvents such as acetone. Examples of the polar protic solvent include: alcohol solvents such as methanol, ethanol, n-propanol, isopropanol, and preferably ethanol.

The above organic solvents may be used singly or in combination of plural kinds. The organic solvent may contain at least a nonpolar solvent, preferably a hydrocarbon solvent, and more preferably n-hexane, in an amount of, for example, 1 to 100 vol%, preferably 30 to 100 vol%, based on the organic solvent, from the viewpoint of preferably obtaining the darkness-suppressing ability and the skin barrier function maintaining or improving ability.

In view of the concentration efficiency, the boiling point of the organic solvent may be 80 ℃ or lower, preferably 70 ℃ or lower.

As the extraction operation, for example, the red pepper can be immersed in an organic solvent by cold immersion, warm immersion, or the like, and stirred or homogenized as necessary to dissolve the active ingredient in the organic solvent. Examples of the organic solvent include hexane, acetone, and ethanol, but it is preferable to use at least hexane from the viewpoint of exerting extraction efficiency, and the ability to suppress dullness and maintain or improve the skin barrier function. The conditions for elution are not particularly limited, and examples thereof include an amount of the organic solvent of 1 to 20 times by weight, preferably 2 to 10 times by weight based on the dry weight of the extracted part, a temperature of, for example, 10 to 50 ℃, preferably 20 to 30 ℃, and a time of 1 to 72 hours, preferably 4 to 48 hours.

The organic solvent component can be separated by solid-liquid separation. The separation method is not particularly limited, and a column separation method, a filtration method, a centrifugation method, and the like are appropriately selected. The separated organic solvent component can be concentrated by removing a part or all of the organic solvent, and a concentrate as a concentrated solution or a dried product can be obtained as the red pepper extract. The dried product can be obtained by drying treatment such as concentration drying, spray drying, freeze drying, etc. The red pepper extract may be obtained by further purification treatment or separation treatment of a high-activity component, if necessary. Examples of the purification treatment include a treatment by filtration or adsorption (an ion exchange resin column, an activated carbon column, or the like). In addition, as the separation treatment of the highly active component, there can be mentioned: gel filtration, adsorption treatment, silica gel column chromatography, HPLC and other treatments.

From the viewpoint of exerting the dullness-suppressing ability and the ability to maintain or improve the skin barrier function, the extract is not subjected to a decomposition treatment such as fermentation. Further, it is preferable that the extract is not subjected to a treatment involving a chemical change other than the decomposition treatment.

[3-3. component ]

Since the raw material of the extract in the present invention is red pepper belonging to non-pungent pepper, the extract does not contain a pungent component in a substantial amount (an amount that generates a pungent taste or irritation as in the case of a pungent pepper component). The pungent component includes capsaicin contained in pungent pepper, and more specifically includes: capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, homodihydrocapsaicin, etc.

Furthermore, the red pepper extract is oil soluble. Oil-soluble means insoluble in water. The oil-soluble extract may contain a component soluble in an organic solvent. The organic solvent is exemplified as the above-mentioned extraction solvent. Therefore, as the component soluble in an organic solvent, examples of the nonpolar solvent-soluble component include: a hydrocarbon solvent-soluble component such as hexane (e.g., n-hexane, cyclohexane, etc.), toluene, preferably hexane (e.g., n-hexane, cyclohexane, etc.), particularly preferably n-hexane; ether solvent-soluble components such as dimethyl ether and diethyl ether; halogenated hydrocarbon solvent-soluble components such as chloroform, dichloromethane, and trichloroethylene; an ester solvent soluble component such as ethyl acetate, and examples of the polar aprotic solvent soluble component include ketone solvent soluble components such as acetone, and examples of the polar protic solvent soluble component include alcohol solvent soluble components such as methanol, ethanol, n-propanol, isopropanol, and preferably ethanol.

The oil-soluble extract may contain one or a combination of a plurality of the above-mentioned soluble components alone. The above-mentioned soluble component preferably contains at least a nonpolar solvent soluble component, preferably a hydrocarbon solvent soluble component, more preferably a hexane soluble component, and particularly preferably a n-hexane soluble component, from the viewpoint of preferably obtaining a dullness-suppressing ability and a skin barrier function-maintaining or-improving ability.

More specifically, the components mainly contained in the oil-soluble extract include lutein, β -carotene, and the like. Examples of xanthophylls include: capsanthin, carotenoid yellow A, beta-cryptoxanthin, zeaxanthin, 3, 6-epoxy capsanthin, capsorubin, cryptocapsanthin, derivatives thereof and the like. Examples of the derivative include fatty acid esters. Specific examples of the fatty acid ester include: esters of saturated or saturated fatty acids having 12 to 22 carbon atoms such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, and the like.

The oil-soluble extract may have a color value (E10% 1cm) of, for example, 300 to 3500, preferably 1000 to 3500, from the viewpoint of exerting the ability to suppress dullness and the ability to maintain or improve the skin barrier function. In the present invention, the color number (E10% 1cm) is a value obtained by measuring the absorbance at the maximum absorption wavelength (460nm) in the visible region of an acetone solution containing the target oil-soluble extract and converting the absorbance into the absorbance of a 10 w/v% acetone solution.

[4. dullness inhibitor and agent for maintaining or improving skin barrier function ]

The darkening inhibitor and the skin barrier function maintaining or improving agent may contain at least the above oil-soluble extract. The darkening inhibitor and the skin barrier function maintaining or improving agent may be prepared as a composition further containing additives corresponding to the manner of application to the living body.

[4-1. modes of application ]

Examples of the application of the darkening inhibitor and the skin barrier function maintaining or improving agent include: skin external preparation, oral preparation, intravenous injection, arterial injection, subcutaneous injection, and muscle preparation. Among these application forms, skin external preparations and oral preparations are preferable, and oral preparations are more preferable, in terms of convenience and efficiency in obtaining the darkness-suppressing property or the skin barrier function maintaining or improving property.

[4-2. application objects ]

Examples of the target to which the darkness-suppressing agent of the present invention is applied include a target for recognizing darkness and for the purpose of suppressing or improving darkness, a target for the purpose of preventing darkness. Further, the target of the use of the darkness-suppressing agent is preferably a person of a higher age group, and specifically, a person of 40 years or older is mentioned.

Examples of the application of the skin barrier function maintaining or improving agent of the present invention include an object for which reduction in skin barrier function is recognized and for which reduction in skin barrier function is suppressed or improved, an object for which reduction in skin barrier function is prevented, and the like. Furthermore, the target of application of the agent for maintaining or improving the skin barrier function is preferably a person in the middle aged and young years who is particularly sensitive to the cause of the reduction in the skin barrier function, and specifically, a person in the age range of 30 years to 40 years may be mentioned.

[4-3. Properties ]

The properties of the darkness-suppressing agent and the skin barrier function-maintaining or-improving agent include: solid (for example, powder, granule, tablet, etc.), liquid (for example, dissolved or dispersed in oil, water, or other solvent), semisolid (for example, dispersed in oil, water, or other base, and in the form of gel, paste, or paste), and the like.

[4-4. external preparation for skin ]

The composition for external application to the skin may contain pharmacologically, cosmetically or pharmaceutically acceptable additives. Such additives include excipients, thickeners, tonicity agents, pH adjusters, stabilizers, preservatives, dispersants, emulsifiers, gelling agents, pigments, perfumes, and the like, depending on the form of the vehicle and preparation. Examples of the shaping include: oil-based, emulsion-based, powder dispersion-based, gel-based, ointment-based, aerosol-based, water-oil dual-layer, or water-oil-powder three-layer. The formulation of the composition for external application to the skin is not particularly limited as long as it can be applied transdermally, and examples thereof include pharmaceuticals for external application to the skin, quasi drugs for external application to the skin, cosmetics, skin detergents, and the like. More specific formulation modes include: skin external medicinal products such as cream, lotion, gel, lotion, liquid, patch, aerosol, ointment, and facial mask; cream, lotion, gel, lotion, liquid, patch, aerosol, ointment, and pellicle; cosmetic materials such as cream, lotion, gel, emulsion, liquid, ointment, and facial mask; skin cleansing agents such as bath lotion, shampoo, and hair conditioner. Of these formulation forms, preferred are skin external pharmaceuticals, and more preferred are creams, lotions, gels, emulsions, and masks.

The amount (in terms of dry weight) of the oil-soluble extract contained in 100% by mass of the skin-function maintaining or improving agent and the dullness inhibitor of the composition for external application to the skin (external preparation) may be, for example, 0.005% by mass to 100% by mass, and preferably 0.02% by mass to 100% by mass. In the present invention, the dry weight equivalent value is a value obtained by converting the amount of the oil-soluble extract of red pepper to a dry weight (amount of dry solid content), and when other components such as a solvent and an additive are contained in the composition, the dry weight equivalent value is a value corresponding to a weight excluding the other components.

Alternatively, the amount of the oil-soluble extract contained in the skin external composition (external preparation) as a dullness inhibitor and a skin barrier function maintaining or improving agent may be such that the color value (E10% 1cm) of the composition itself becomes 0.1 to 3500, preferably 0.5 to 3500.

The amounts of the skin darkening inhibitor and the skin barrier function maintaining or improving agent to be used as the composition for external application to the skin (external preparation) may be appropriately set according to the excipient, the preparation method, the degree of the skin symptom to be applied, and the like. Specific examples of the amount of the oil-soluble extract include about 1 to several times per 1 day of 1cm2 skin, and about 0.1 to 6. mu.g/1 time, preferably 0.4 to 3. mu.g/1 time, in terms of the amount of the oil-soluble extract (dry weight equivalent).

Alternatively, as examples of the amount of the skin external composition (external preparation) used as a darkening inhibitor and a skin barrier function maintaining or improving agent, there may be mentioned, for example, about 1 to several times per 1 day of 1cm2 of skin, about 0.0004 to 0.02/1, preferably 0.001 to 0.008/1, in terms of the total color number (E10% 1cm) × weight (g)).

[4-5. oral preparations ]

Examples of the composition for oral administration include: health food, functional food, nutritional supplementary food, and specific health food. In the composition for oral administration, additives allowable in food hygiene may be incorporated. Examples of such additives include sweeteners such as glucose, sucrose, fructose, isomerized liquid sugar, aspartame, and stevia; sour materials such as citric acid, malic acid, tartaric acid, etc.; dextrin, starch and other excipients; a diluent such as a binder and oil, a perfume, a coloring material, a buffer, a thickener, a gelling agent, a stabilizer, a preservative, an emulsifier, a dispersant, a suspending agent, a preservative, and the like. Examples of the darkening inhibitor and the skin barrier function maintaining or improving agent of the composition for oral administration include: supplements such as tablets, hard capsules and soft capsules, various beverages (refreshing beverages, carbonated beverages, beauty beverages, nutritional beverages, fruit beverages, milk beverages, and the like), concentrated stock solutions and powders for conditioning of the beverages, oils and fats, processed foods of oils and fats, seasonings, and the like.

The amount (in terms of dry weight) of the oil-soluble extract contained in 100% by mass of the sunless tanning inhibitor and skin barrier function maintaining or improving agent as an oral composition (oral agent) may be, for example, 0.005% by mass to 100% by mass, preferably 0.01% by mass to 100% by mass.

Alternatively, the amount of the oil-soluble extract contained in the sunless tanning inhibitor and the skin barrier function maintaining or improving agent as the composition for oral administration (oral preparation) may be such that the color value (E10% 1cm) of the composition itself becomes 0.1 to 3500, preferably 0.2 to 3500.

The amounts of the suntan inhibitor and the skin barrier function maintaining or improving agent to be used as the composition for oral administration (oral preparation) may be appropriately set according to the excipient, the preparation method, the degree of the applied skin symptom, and the like. Specific examples of the amount of the oil-soluble extract include an amount of 10mg to 400mg/1 day, preferably 50mg to 200mg/1 day, which is taken 1 to several times a day, for example, in terms of the amount of the oil-soluble extract (dry weight equivalent).

Alternatively, the amount of the darkening inhibitor and the skin barrier function maintaining or improving agent to be used in the composition for oral administration (oral preparation) may be, for example, about 1 to several times per 1 day for 30 to 1000/1 days, preferably 200 to 500/1 days, in terms of the total color value (E10% 1cm) × weight (g)).