阅读说明：本技术 一种氮杂芳基衍生物、其制备方法和在药学上的应用 (Azaaryl derivative, preparation method and pharmaceutical application thereof ) 是由 赵保卫 张鸣鸣 喻红平 陈椎 徐耀昌 于 2018-05-22 设计创作，主要内容包括：一种具有式(Ⅰ)结构的氮杂芳基衍生物、其制备方法和在药学上的应用。本发明系列化合物可广泛应用于制备治疗癌症、肿瘤、自身免疫性疾病、代谢性疾病或转移性疾病的药物,特别是治疗卵巢癌、胰腺癌、前列腺癌、乳腺癌、宫颈癌、成胶质细胞瘤、多发性骨髓瘤、代谢性疾病、神经变性疾病、原发性肿瘤位点的转移或骨转移性癌症的药物,有望开发成新一代CSF1R抑制剂药物。<Image he="308" wi="700" file="DDA0002217080820000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>(An azaaryl derivative with a structure shown as a formula (I), a preparation method and application thereof in pharmacy. The series of compounds can be widely applied to preparing medicines for treating cancers, tumors, autoimmune diseases, metabolic diseases or metastatic diseases, in particular to medicines for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic diseases, neurodegenerative diseases, primary tumor site metastasis or bone metastatic cancer, and are expected to be developed into new generation CSF1R inhibitor medicines.)