阅读说明：本技术 载杆本体、冷冻载杆及载杆本体的制造方法 (Carrier bar body, freezing carrier bar and manufacturing method of carrier bar body ) 是由 王羽 滕晓明 乔卞卞 吴艳雪 于 2021-06-24 设计创作，主要内容包括：本发明提供了一种载杆本体,用于承载配子/胚胎溶液,包括连接段和载片,所述载片位于所述连接段的远端并与所述连接段一体成型,所述连接段的近端区域至少一部分呈管状或柱状。所述载片的承载面为弧面,所述载片旨在承载配子/胚胎溶液,所述载片的承载面为弧面可避免配子/胚胎溶液掉落,所述载片厚度较薄,可大幅提升配子/胚胎溶液冷冻速率。在本发明中,所述载杆本体的连接段和载片为一个结构整体,使得载片不易出现折弯,有利于减少配子/胚胎溶液掉落的概率。相应的,本发明还提供了一种冷冻载杆,具有制造难度更低,有利于降低制造成本的优点。(The invention provides a carrying rod body for carrying gamete/embryo solution, which comprises a connecting section and a slide glass, wherein the slide glass is positioned at the far end of the connecting section and is integrally formed with the connecting section, and at least one part of the near end area of the connecting section is tubular or columnar. The bearing surface of the slide glass is a cambered surface, the slide glass is used for bearing gamete/embryo solution, the gamete/embryo solution can be prevented from falling off due to the fact that the bearing surface of the slide glass is a cambered surface, the slide glass is thin, and the freezing rate of the gamete/embryo solution can be greatly improved. In the invention, the connecting section of the carrying rod body and the carrying sheet are integrated into a whole structure, so that the carrying sheet is not easy to bend, and the probability of dropping gamete/embryo solution is favorably reduced. Correspondingly, the invention also provides a freezing carrying rod which has the advantages of lower manufacturing difficulty and contribution to reducing the manufacturing cost.)

1. A rod carrying body for carrying a gamete or embryo solution, comprising: the slide glass is positioned at the far end of the connecting section and is integrally formed with the connecting section, and at least one part of the near end area of the connecting section is tubular or columnar.

2. The carrier bar body of claim 1 wherein the bearing surface of the carrier sheet is arcuate.

3. The carrier rod body as claimed in claim 1, wherein the slide comprises a tip region, an embryo-carrying region and a transition region connected with each other from a distal end to a proximal end, and a cross-sectional width of the embryo-carrying region in a direction perpendicular to the axis is smaller at the distal end than at the proximal end.

4. The carrier bar body of claim 3 wherein the tip section is triangular or semi-circular in cross-section along the axis, the base of the triangle or semi-circle being connected to the distal end of the embryo-carrying section.

5. The carrier rod body of claim 3 wherein the transition region tapers in cross-sectional height perpendicular to the axis from the proximal end to the distal end.

6. A frozen bar, comprising:

the protection sleeve is closed at the far end and provided with a first opening at the near end;

the sealing unit is used for sealing the first opening so as to enable the protective sleeve to form a closed space; and the number of the first and second groups,

the carrier bar body of any of claims 1-5, the carrier bar body being located within the enclosed space.

7. A freeze carrier bar as claimed in claim 6 wherein the closure unit is a closure member for removable connection with the first opening to close the first opening.

8. The freeze carrier bar of claim 6, wherein the sealing unit is a heat shrink disposed proximate the first opening, the heat shrink being heated to seal the proximate end of the protective sleeve.

9. The freezing bar of claim 6 wherein said closing unit is a handle, and comprises a first connecting portion, a second connecting portion and a handle portion from a distal end to a proximal end, said first connecting portion is configured to extend into said first opening and to be in interference fit with said connecting portion, and said second connecting portion is configured to be detachably connected to said proximal end of said protective sleeve to close said first opening.

10. A freeze carrier bar as set forth in claim 9 wherein said handle further has a boss portion located outside of said protective sleeve and disposed at a proximal end of said second connector portion, said boss portion having an outer diameter greater than said first opening.

11. The frozen carrier bar of claim 9 wherein the distal end of the first connector portion is further provided with a guide portion having a cross-sectional area perpendicular to the axis that is smaller than the cross-sectional area perpendicular to the axis of the distal end of the first connector portion.

12. The frozen carrier bar of claim 11 wherein the guide is a cone-shaped structure or a hemispherical structure, the bottom end of the cone-shaped structure or hemispherical structure being connected to the distal end of the first connector.

13. The freeze bar of claim 9, wherein the handle has two opposing sidewalls, one of which is inwardly concave and the other of which is outwardly convex.

14. The freeze carrier bar of claim 9, wherein the first connection portion has an interference connection section and a flat section connected to each other, the interference connection section having an outer diameter greater than an outer diameter of the flat section.

15. The freeze bar of claim 14, wherein the interference fit segment has a length of 3mm to 5mm and the handle has a length of 45mm to 60 mm.

16. A freeze carrier bar as in claim 6 wherein a counterweight and a desiccant are disposed in the enclosed space from the distal end to the proximal end.

17. The freeze carrier bar of claim 16, wherein the material of the weight has a density greater than the density of the material of the protective sleeve.

18. The chilled carrier rod of claim 16, wherein the desiccant portion includes at least two vapor barriers, and a desiccant is disposed between adjacent vapor barriers.

19. A frozen carrier bar as recited in claim 18 wherein the gas barrier is made of a non-woven fabric.

20. The freeze bar of claim 6, further comprising a plug, wherein the distal end of the protective sleeve has a second opening, and wherein the plug closes the second opening.

21. The freeze bar of claim 20, wherein the plug is a stainless steel plug.

22. The freeze carrier bar of claim 20, wherein the distal region of the plug is hemispherical and is disposed outside the protective sleeve, and the proximal region of the metal plug is cylindrical and is in interference fit with the distal region within the protective sleeve to close the second opening.

23. A method of manufacturing a carrier bar body, comprising:

providing a pipe, and cutting the pipe to obtain the carrier rod body according to any one of claims 1-5, so that the carrier rod body has a connecting section and a slide, wherein the connecting section is tubular or cylindrical.

24. The method of manufacturing a carrier rod body according to claim 23, wherein the cutting of the tube is performed by cutting the tube along an axial direction of the tube with a profiled blade to obtain the carrier rod body.

Technical Field

The invention relates to the technical field of medical instruments, in particular to a carrying rod body, a freezing carrying rod and a manufacturing method of the carrying rod body.

Background

In recent years, assisted reproduction techniques have been widely used for treating infertility, with the increase of patients with infertility. Assisted reproduction is a short-term assisted reproduction technology for human beings, and refers to a technology for making sterile couples pregnant by adopting medical auxiliary means, and comprises two major technologies of artificial insemination, in vitro fertilization-embryo transplantation and derivation. In the ivf-embryo transfer (also called tube baby) technology, the freezing and recovery work of gametes/embryos is a derivative technology in the assisted reproduction technology.

Gamete/embryo freezing technology is widely used for gamete/embryo preservation in order to make rational use of embryos and reduce maternal-infant risks associated with ovulation induction. Compared with the traditional programmed freezing technology, the vitrification freezing is a new freezing method, the ultra-fast cooling rate greatly inhibits the formation of ice crystals in gametes/embryos, and therefore good survival rate, pregnancy rate and development potential of the gametes/embryos are guaranteed. Cryopreservation of gametes/embryos in the field of assisted reproduction provides a wider choice for patients with infertility, which has become one of the indispensable technologies in assisted reproduction technology. In the process of vitrifying cryopreservation of gametes/embryos, cryopreservation of gametes/embryos is generally performed by using a freezing carrying rod as a carrier.

Slides in the freezing slide bar are used to carry gametes/embryos, however slides that are too thick are not conducive to temperature transfer, directly affecting the efficiency of freezing gametes/embryos and the recovery rate of gametes/embryos. The thin slide can accelerate the heat transfer efficiency, greatly improve the freezing efficiency of gametes/embryos when gametes/embryos are frozen, improve the thawing rate of gametes/embryo solutions when gametes/embryos are thawed, and greatly inhibit the formation of ice crystals in gametes/embryos at a higher cooling rate, so that embryo gametes/embryos are ensured to have good survival rate, pregnancy rate and development potential. However, the thinner carrier sheet also causes the mechanical property of the carrier sheet to be weaker, and the problem of carrier sheet bending is easy to occur in practice.

Disclosure of Invention

The invention aims to provide a carrying rod body, a freezing carrying rod and a manufacturing method of the carrying rod body.

In order to achieve the above object, the present invention provides a rod carrier body for carrying a gamete solution or embryo solution, the rod carrier body comprising: the slide glass is positioned at the far end of the connecting section and is integrally formed with the connecting section, and at least one part of the near end area of the connecting section is tubular or columnar.

Optionally, the carrying surface of the slide is an arc surface.

Optionally, the slide comprises a tip region, an embryo-carrying region and a transition region which are connected with each other from the far end to the near end, and the cross-sectional width of the far end of the embryo-carrying region along the direction perpendicular to the axis is smaller than that of the near end of the embryo-carrying region along the direction perpendicular to the axis.

Optionally, the tip region is triangular or semicircular, and the bottom side of the triangle or the semicircle is connected with the far end of the embryo-carrying region.

Optionally, the transition zone gradually shrinks in cross-sectional width in the axial direction from the proximal end to the distal end.

Correspondingly, the invention also provides a freezing loading rod, which comprises:

the protection sleeve is closed at the far end and provided with a first opening at the near end;

the sealing unit is used for sealing the first opening so as to enable the protective sleeve to form a closed space; and the number of the first and second groups,

the carrying rod body is positioned in the closed space.

Optionally, the sealing unit is a sealing member, and is configured to be detachably connected to the first opening to seal the first opening.

Optionally, the sealing unit is a heat shrink, and is disposed at the proximal end of the first opening, and the proximal end of the protection sleeve is sealed by heating the heat shrink.

Optionally, the sealing unit is a handle, and is a first connecting portion, a second connecting portion and a handheld portion from a far end to a near end, the first connecting portion is used for extending into the first opening and is in interference fit with the connecting section, and the second connecting portion is detachably connected with the near end of the protective sleeve to close the first opening.

Optionally, the handle further has a boss portion, the boss portion is located outside the protective sleeve barrel and is disposed at the proximal end of the second connecting portion, and an outer diameter of the boss portion is greater than the first opening.

Optionally, a guide portion is further disposed at a distal end of the first connection portion, and a cross-sectional area of the distal end of the guide portion along a direction perpendicular to the axis is smaller than a cross-sectional area of the distal end of the first connection portion along the direction perpendicular to the axis.

Optionally, the guiding portion is a cone-shaped structure or a hemispherical structure, and a bottom end of the cone-shaped structure or the hemispherical structure is connected to a distal end of the first connecting portion.

Optionally, the handle portion has two opposing side walls, one of which is inwardly concave and the other of which is outwardly convex.

Optionally, the first connecting portion has an interference connecting section and a straight section, a proximal end of the interference connecting section is connected with a distal end of the straight section, and an outer diameter of the interference connecting section is greater than an outer diameter of the straight section.

Optionally, the length of the interference connection section is 3 mm-5 mm, and the length of the handheld portion is 45 mm-60 mm.

Optionally, a counterweight part and a drying part are respectively arranged in the closed space from the far end to the near end.

Optionally, the density of the material of the weight portion is greater than the density of the material of the protective sleeve.

Optionally, the drying portion includes at least two air-blocking layers, and a drying agent is disposed between the adjacent air-blocking layers.

Optionally, the gas barrier layer is made of non-woven fabric.

Optionally, the protective sleeve further comprises a plug, a distal end of the protective sleeve has a second opening, and the plug plugs the second opening.

Optionally, the plug is a stainless steel plug.

Optionally, the distal end region of the plug is hemispherical and is located outside the protective sleeve, and the proximal end region of the metal plug is cylindrical and is in interference fit with the distal end region in the protective sleeve to close the second opening.

Correspondingly, the invention also provides a manufacturing method of the carrying rod body, which comprises the following steps:

providing a pipe, and cutting the pipe to obtain a carrying rod body, so that the carrying rod body is provided with a connecting section and a carrying sheet, wherein the connecting section is tubular or cylindrical.

Optionally, when the pipe is cut, the pipe is cut along the axial direction of the pipe by the special-shaped blade, so that the carrier bar body is obtained.

The slide glass is positioned at the far end of the connecting section and is integrally formed with the connecting section, and at least one part of the near end area of the connecting section is tubular or columnar. The connecting section of the carrying rod body and the carrying sheet are integrated into a whole, so that the carrying sheet is not easy to bend.

In addition, the bearing surface of slide glass is the cambered surface, and the cambered surface can avoid gamete/embryo solution to drop. The bearing surface with the arc-shaped surface provides a larger contact area for liquid drops of the gamete/embryo solution and liquid nitrogen, so that the heat transfer efficiency can be accelerated, and the gamete/embryo has higher freezing efficiency.

The freezing carrier bar comprises a protective sleeve and a carrier bar body, wherein the distal end of the protective sleeve is closed, the proximal end of the protective sleeve is provided with a first opening, the sealing unit is used for closing the first opening so that the protective sleeve forms a closed space, and the carrier bar body is positioned in the protective sleeve.

In addition, the sealing unit is a sealing piece and is used for being detachably connected with the first opening so as to seal the first opening.

In addition, the sealing unit is a thermal contraction opening which is arranged at the proximal end of the first opening and is used for sealing the proximal end of the protection sleeve by heating the thermal contraction opening.

In addition, seal the unit and be the handle, by distal end to near-end be first connecting portion, second connecting portion and handheld portion respectively, first connecting portion be used for stretching into in the first opening with linkage segment interference fit, the second connecting portion with the proximal end of protective sleeve can be dismantled and be connected, in order to seal first opening. The first connecting part is in interference fit with the connecting section to be fixedly connected, and the freezing carrying rod is fixed relative to the handle and the carrying sheet in a dispensing or welding mode.

In addition, first connecting portion with linkage segment interference fit is with fixed connection for carry the pole body and can dismantle with the handle and link to each other, the doctor can select the handle of different length according to self use habit, with the length of adjustment freezing year pole.

Correspondingly, the invention also provides a manufacturing method of the carrying rod body, which comprises the following steps: providing a pipe, and cutting the pipe to obtain a carrying rod body, so that the carrying rod body is provided with a connecting section and a carrying sheet, wherein the connecting section is tubular or cylindrical. The method has the advantages of lower manufacturing difficulty and contribution to reducing the manufacturing cost.

Drawings

FIG. 1 is a top view of a freezing bar according to a first embodiment of the present invention;

FIG. 2 is a top view of a carrier bar body according to a first embodiment of the present invention;

FIG. 3 is a front view of a carrier bar body according to a first embodiment of the present invention;

FIG. 4 is a top view of a handle according to a first embodiment of the present invention;

fig. 5 is a top view of a protective sleeve according to a first embodiment of the present invention;

FIG. 6 is a flow chart of a method of manufacturing a frozen bar according to a first embodiment of the present invention;

FIG. 7 is a top view of a handle according to a second embodiment of the present invention;

FIG. 8 is a top view of a handle according to a third embodiment of the present invention;

FIG. 9 is a top view of a freeze carrier bar according to a fourth embodiment of the present invention;

FIG. 10 is a top view of a carriage body according to a fourth embodiment of the present invention;

fig. 11 is a top view of a protective sleeve according to a fourth embodiment of the present invention;

FIG. 12 is a top view of a freeze carrier bar according to a fifth embodiment of the present invention;

wherein the reference numbers are as follows:

100-a protective sleeve; 110-a weight; 120-drying the pressed powder; 121-gas barrier layer; 122-a desiccant; 130-a second opening; 140-a first opening; 150-plug; 160-a cannula;

200-a carrier bar body; 210-a slide; 211-tip region; 212-an embryo-bearing region; 213-a transition region; 220-a connecting segment;

300-a handle; 310-a first connection; 311-straight section; 312-an interference connection section; 320-a second connection; 330-a hand-held part; 340-a guide; 350-a boss portion; the closure 400.

Detailed Description

The following describes in more detail embodiments of the present invention with reference to the schematic drawings. The advantages and features of the present invention will become more apparent from the following description. It is to be noted that the drawings are in a very simplified form and are not to precise scale, which is merely for the purpose of facilitating and distinctly claiming the embodiments of the present invention.

The definitions of "distal" and "proximal" herein are: "distal" generally refers to the end of the medical device that is distal from the operator during normal operation, while "proximal" generally refers to the end of the medical device that is proximal to the operator during normal operation.

Example one

Fig. 1 is a top view of a freezing bar according to the present embodiment, and fig. 2 is a top view of a bar body according to the first embodiment of the present invention. As shown in fig. 1, 2 and 5, the freezing slide includes a protection sleeve 100, a capping unit and a slide body 200. Wherein the distal end of the protection sleeve 100 is closed and the proximal end of the protection sleeve 100 has a first opening 140. The sealing unit is used for sealing the first opening 140, so that the protection sleeve 100 forms a closed space. In this embodiment, the sealing unit is a handle 300. The rod carrier body 200 is located in the enclosed space inside the protection sleeve 100.

Further, the slide bar body 200 is used for carrying gamete/embryo solution, the slide bar body 200 comprises a connecting section 220 and a slide 210, the slide 210 is located at the distal end of the connecting section 220 and is integrally formed with the connecting section 220, and at least one part of the proximal end area of the connecting section 220 is tubular or cylindrical.

In particular implementations, slide 210 is used to carry a gamete/embryo solution. Preferably, the bearing surface of the slide 210 is an arc surface, and when the liquid drop of the gamete/embryo solution is dropped on the slide 210, the arc of the bearing surface can be matched with the surface arc of the liquid drop of the gamete/embryo solution under the natural weight bearing condition, so that the contact surface between the liquid drop of the gamete/embryo solution and the bearing surface of the slide 210 is larger, the adsorption force of the slide 210 on the liquid drop of the gamete/embryo solution is stronger, and the gamete/embryo solution can be prevented from dropping.

In addition, the connecting section 220 of the slide bar body 200 and the slide 210 are an integral structure, so that the slide 210 is not easy to bend, and the gamete/embryo solution can be further prevented from falling. In addition, the connecting section 220 of the slide bar body 200 and the slide 210 are an integral structure, so that the thickness of the slide 210 can be conveniently made thinner, and it should be understood that the slide 210 with too thick thickness is not beneficial to temperature transmission, and directly influences the freezing efficiency of gamete/embryo solution and the recovery rate of gamete/embryo. The thinner slide 210 can accelerate the heat transfer efficiency, greatly improve the freezing efficiency of the gamete/embryo solution when the gamete/embryo solution is frozen, improve the thawing rate of the gamete/embryo solution when the gamete/embryo is thawed, and greatly inhibit the formation of ice crystals in the gamete/embryo at a faster cooling rate, thereby ensuring that the embryo gamete/embryo has good survival rate, pregnancy rate and development potential. In this embodiment, the thickness of the carrier sheet 210 can be made 0.02mm to 0.1mm, or even thinner.

It will be appreciated that the curved surface can act as a light-focusing feature, which makes gametes/embryos on the carrying surface of slide 210 more easily observable. In addition, the gamete/embryo solution drops on the arc surface, the sliding direction of the gamete/embryo solution is limited, and therefore, the freezing carrying rod of the invention is beneficial for a user to operate the gamete/embryo on the slide 210.

Fig. 3 is a front view of the carrier rod body 200 according to the first embodiment of the invention. As shown in fig. 2 and 3, the slide sheet 210 has a tip region 211, an embryo-carrying region 212 and a transition region 213 from a distal end to a proximal end, and the cross-sectional width of the embryo-carrying region 212 in the direction perpendicular to the axis is smaller at the distal end than at the proximal end of the embryo-carrying region 212 in the direction perpendicular to the axis. Further, the tip section 211 is a semicircle, and the bottom of the semicircle is connected to the distal end of the embryo-carrying section 212.

It should be appreciated that tip region 211 is semi-circular, and tip region 211 acts as a guide for slide 210 as slide 210 enters protective sleeve 100, thus further avoiding handling protective sleeve 100 to hit slide 210 to prevent gamete/embryo solution on slide 210 from falling off.

In addition, the embryo-carrying region 212 of the slide 210 has a cross-sectional width perpendicular to the axial direction at the distal end thereof smaller than that at the proximal end of the embryo-carrying region 212. I.e., the tip region 211 to the transition region 213, the width of the slide 210 gradually increases. Stress concentration caused by sudden change of the width of the slide sheet 210 can be avoided, and high mechanical property is provided. Moreover, the design that the width of the slide 210 gradually shrinks from the proximal end to the distal end can further prevent the protective sleeve 100 from colliding with the slide 210 when the protective sleeve 100 is sleeved by an operator, so as to prevent gamete/embryo solution on the slide 210 from falling off. In one embodiment of this example, the width of the distal end of the embryo carrying region 212 is 1.35mm, and the width of the proximal end of the embryo carrying region 212 is 1.70 mm.

Alternatively, from the proximal end to the distal end of the transition region 213, the transition region 213 has a cross-sectional height that decreases in a direction perpendicular to the axis. As can be seen from FIG. 3, the transition region 213 is designed to have a circular arc transition, and when the user sleeves the slide rod body 200 into the protective sleeve 100, the transition region 213 serves as a guide to prevent the protective sleeve 100 from colliding with the slide 210, so as to prevent the gamete/embryo solution on the slide 210 from falling off.

Fig. 4 is a plan view of the handle in this embodiment. As shown in fig. 4, from the distal end to the proximal end of the handle 300, there are a first connecting portion 310, a second connecting portion 320 and a handle portion 330, respectively, the first connecting portion 310 is used for extending into the first opening 140 to be in interference fit with the connecting segment 220, and the second connecting portion 320 is detachably connected to the proximal end of the protection sleeve 100 to close the first opening 140.

In detail, the connecting section 220 of the carrier bar body 200 is inserted into the first connecting portion 310 of the handle 300, the first connecting portion 310 is in interference fit with the connecting section 220 of the carrier bar body 200, the interference magnitude (i.e., the difference between the inner diameter of the connecting section 220 and the outer diameter of the first connecting portion 310) is 0.07-0.15mm, and the length of the interference fit (i.e., the length of the connecting section 220 coinciding with the first connecting portion 310) is 3 mm-5 mm. Therefore, the first connecting part 310 can be tightly matched with the connecting section 220, so that the connecting rod body 200 and the handle 300 are very firmly connected and are not easy to fall off in the using process.

Optionally, a guide portion 340 is further disposed at a distal end of the first connection portion 310, the guide portion 340 and the first connection portion 310 may be separated or integrally formed, as shown in fig. 4, the first connection portion 310 and the guide portion 340 are integrally formed, and a cross-sectional area of the distal end of the guide portion 340 along a direction perpendicular to the axis is smaller than a cross-sectional area of the distal end of the first connection portion 310 along a direction perpendicular to the axis. In this way, when the first connection portion 310 is plugged into the connection segment 220, the guiding portion 340 plays a guiding role.

Further, the guiding portion 340 is a cone-shaped structure or a semi-spherical structure, and the bottom end of the cone-shaped structure or the semi-spherical structure is connected to the distal end of the first connecting portion 310. It should be appreciated that the profile of the guide 340 may also be adapted based on experience of one skilled in the art.

Optionally, the handle 300 further has a boss portion 350, the boss portion 350 is located outside the protection sleeve 100 and is disposed at the proximal end of the second connecting portion 320, and the outer diameter of the boss portion 350 is larger than the first opening 140. It will be appreciated that the boss portion 350 can function as a stop, while the boss portion 350 also serves to identify the nesting position of the protective sleeve 100.

Optionally, the handle 330 has two opposing sidewalls, one of which is inwardly concave and the other of which is outwardly convex. It is understood that the handle 300 has a shape of approximately a rectangular parallelepiped, one side of which is convex and the other side of which is concave. The handle 300 thus constructed has an advantage of being convenient to hold.

In addition, the length of the handle 300 is adjustable, the preferred range is 45-60 mm, and a user can mark patient information through the handles 300 with different lengths.

Further, the handle 300 has a plurality of colors, and the color of the handle 300 is used as the marking information.

Gamete/embryo solutions are usually loaded onto freezing bars and placed in freezing aluminum baskets for cryopreservation, since multiple freezing bars are stored in one freezing aluminum basket, if the freezing bars are not physically isolated from each other, there is a possibility that the freezing bars in the freezing aluminum baskets will be contaminated with each other. Based on this, the slide 210 is placed in the protective sleeve 100 to provide physical separation between the freezing slide bars.

It will be appreciated that since the protective sleeve 100 is typically made of medical grade plastic, the plastic is light in weight and tends to float when placed in liquid nitrogen, which in turn causes the protective sleeve 100 to fall off the handle 300, which in turn causes the gametes/embryos on the slide 210 to come into direct contact with the liquid nitrogen in the frozen aluminum basket. Gametes/embryos that are in direct contact with liquid nitrogen have the problem of being contaminated and polluting the liquid nitrogen by the liquid nitrogen. In order to solve the above problems, the present invention provides a protective sleeve 100.

Fig. 5 is a plan view of the protective sleeve in this embodiment. As shown in fig. 5, a weight portion 110 and a dry portion 120 are provided in the protection sleeve 100 from the distal end to the proximal end, respectively.

Further, the density of the material of the weight portion 110 is greater than that of the material of the protection sleeve 100. I.e., the density of the material of the weight 110 should be greater than the density of the medical grade plastic. Preferably, the material of the weight portion 110 is metal, and more preferably, the material of the weight portion 110 is stainless steel. The stainless steel has more stable chemical properties, and cannot generate chemical reaction with liquid nitrogen, so that the liquid nitrogen is polluted.

In this embodiment, the weight portion 110 is a metal ring made of stainless steel. The metal ring is arranged in the protective sleeve 100, and the periphery of the metal ring is attached to the inner wall of the protective sleeve 100. Because the effect of becket self gravity for protective sleeve 100's in the liquid nitrogen distal end is down, has avoided protective sleeve 100 to appear showy phenomenon in freezing aluminium hand-basket, simultaneously because slide 210 of this application has good heat transfer efficiency, and gamete embryo solution that adsorbs on slide 210 cools off fast promptly putting into the liquid nitrogen container, is favorable to reducing gamete embryo because of protective sleeve 100 drops and the pollution risk that causes with the liquid nitrogen contact.

Referring to fig. 5, the drying portion 120 includes at least two air barriers 121, and a drying agent 122 is disposed between adjacent air barriers 121.

Further, the gas barrier layer 121 is made of a non-woven fabric.

In this embodiment, the outer walls of the dry portions 120 are all attached to the inner wall of the protection sleeve 100. The drying part 120 is composed of two pie-shaped gas barriers 121 made of non-woven fabric, and the gas barrier 121 made of non-woven fabric, which has a porous structure inside, can be used for absorbing moisture. A cake-like desiccant 122 is sandwiched between the gas barrier layers 121. The water absorbing capacity of the drying part 120 can be further improved. So that the dry portion 120 can absorb moisture possibly remaining in the protection sleeve 100 as much as possible.

It should be noted that the materials of the protection sleeve 100, the carrier rod body 200 and the handle 300 in the present embodiment are medical plastics, specifically at least one of PET, PS, SBS, SBC and K-Resin. It should be understood that PET, PS, SBS, SBC, and K-Resin are currently common medical plastics, and can meet the performance requirements of the carrier rod body 200 in terms of strength, transparency, and temperature resistance, and meanwhile, are convenient to obtain. Thus, the fabrication of the slides 210 using PET and/or PS and/or SBS and/or SBC and/or K-Resin may reduce the cost of manufacturing the frozen slide bars.

Further, the protection sleeve 100 has a plurality of colors, and the color of the protection sleeve 100 is used as a marking information. In an alternative embodiment of this embodiment, the handle 300 and the protection sleeve 100 are provided with a plurality of colors, and the combination of the colors of the handle 300 and the protection sleeve 100 is used as the marking information.

Correspondingly, the invention also provides a manufacturing method of the carrying rod body. When the slide bar body is manufactured, a pipe is provided, and the pipe is cut to obtain the slide bar body 200, so that the slide bar body 200 is provided with a connecting section 220 and a slide 210, and the connecting section is tubular or cylindrical.

Correspondingly, the invention also provides a manufacturing method of the freezing carrying rod.

Fig. 6 is a flowchart of a method of manufacturing the freezing bar in this embodiment. As shown in fig. 6, the method for manufacturing the freezing carrier bar comprises the following steps:

step S101: providing a pipe, cutting the pipe to obtain a carrying rod body 200, wherein the carrying rod body 200 is provided with a connecting section 220 and a carrying sheet 210, the carrying surface of the carrying sheet 210 is an arc-shaped surface, and the connecting section 220 is tubular.

Step S102: a protective sleeve 100 is provided, which has a first opening 140 at its proximal end, and the slide bar body 200 is placed inside the protective sleeve 100 through the first opening 140.

Further, after laser cutting the tube to obtain a rod carrier body 200, before placing the rod carrier body 200 into the protection sleeve 100 through the first opening 140, the method further comprises the following steps:

providing a handle 300, which is a first connecting portion 310, a second connecting portion 320 and a handheld portion 330 from the distal end to the proximal end, and fixedly connecting the first connecting portion 310 and the connecting section 220 in an interference fit manner.

The cutting method of the carrier bar body 200 may be that the cutting tool is fed radially from the outer edge of the pipe and the cutting direction of the cutting tool is continuously changed, or that the cutting tool is used to cut the pipe along the axial direction of the pipe by using a special-shaped blade, one end of the special-shaped blade has an arc-shaped edge part for cutting the nearer end of the pipe, the nearer end is the transition region 213 obtained by cutting, and the shape of the edge part is matched with the shape of the transition region 213.

It should be appreciated that the slide 210 may be held to the handle 300 by a conventional freezing slide bar, such as by glue or welding the slide 210. However, the glue tends to fail during liquid nitrogen storage of the cryoslide bar, and thus, there is a risk that the slide 210 will fall off. In addition, the handle 300 is usually made of polymer material, and the slide 210 is connected to the handle 300 in a welding manner, which wastes energy, consumes labor hours, and has high cost. In addition, the high temperature associated with welding can damage the polymer material, resulting in a lower structural strength at the connection between the handle 300 and the slide 210. In addition, the handle 300 and the slide glass 210 are integrally connected through dispensing or welding, so that the handle is difficult to detach, and a user cannot adjust the length of the slide glass according to own use habits. The handle 300 of the present invention is tightly fitted with the rod carrier body 200 to achieve a fixed connection, so as to solve the above-mentioned problems.

After the slide bar body 200 is placed in the protection sleeve 100 through the first opening 140, the method further comprises the following steps:

the protection sleeve 100 is detachably sleeved on the second connecting portion 320 to close the first opening 140.

Optionally, when the rod carrier body 200 is manufactured, the tube is cut by a laser cutting process or a mechanical cutting process to obtain the rod carrier body 200.

The laser cutting process is to irradiate the pipe with focused high power density laser beam to melt, vaporize and ablate the irradiated part fast or reach burning point, and blow off the molten matter with the help of high speed airflow coaxial with the beam to cut the pipe. Because the laser cutting has no cutter processing cost, the laser cutting process is used for producing small-batch products and has high cost performance. In addition, laser cutting also has the advantages of high cutting speed and high quality.

Optionally, when the rod carrier body 200 is manufactured, the tube is cut by a mechanical cutting process, and the tube is cut by a special-shaped blade along the axial direction of the tube.

Example two

The same portions of the freezing bar provided in this embodiment as those in the first embodiment will not be described here, and only different points will be described below.

Fig. 7 is a plan view of the handle in this embodiment. As shown in fig. 7, the present embodiment is different from the first embodiment in that: the handle 330 is cylindrical.

It should be noted that, in contrast to the first embodiment, the handle 300 is approximately rectangular in shape, with one side surface being convex and the opposite side surface being concave. The handheld portion 330 of the present embodiment is cylindrical, has a more compact shape, can be conveniently manufactured, and is beneficial to reducing the cost of the handle 300.

Optionally, the handle 300 is manufactured by an injection molding process, which facilitates mass production and is beneficial to further reduce the manufacturing cost of the handle 300.

EXAMPLE III

The same portions of the freezing bar provided in this embodiment as those in the first and second embodiments will not be described here, and only different points will be described below.

Fig. 8 is a plan view of the handle in this embodiment. As shown in fig. 8, the present embodiment is different from the first embodiment in that: the first connection portion 310 of the handle 300 has an interference connection section 312 and a straight section 311, the interference connection section 312 is connected to the straight section 311, and the outer diameter of the interference connection section 312 is larger than the outer diameter of the straight section 311.

Specifically, as shown in fig. 8, the interference connection section 312 is located in the middle of the flat section 311, so that the first connection portion 310 has a three-segment discontinuous cylindrical structure, wherein the first flat section is located at the distal end of the interference connection section 312, and the second flat section is located at the proximal end of the interference connection section 312. Further, the length of the interference connection section 312 is 3mm to 8 mm. The interference of the interference connection section 312 (i.e. the difference between the inner diameter of the interference connection section 312 and the outer diameter of the first connection part 310) is 0.07-0.15 mm. Thus, the first connecting portion 310 is tightly matched with the connecting section 220 of the carrying rod body 200, so that the carrying rod body 200 is firmly connected with the handle 300 and is not easy to fall off in the using process. In addition, the first connection portion 310 is designed to have the interference connection section 312 and the flat section 311, which is more convenient when the first connection portion 310 is plugged with the connection section 220.

Furthermore, in another embodiment of the present embodiment, the interference connection section 312 is located at the distal end of the straight section 311. The first connection portion 310 with such a structure can also facilitate the insertion of the first connection portion 310 with the connection section 220.

Example four

The same portions of the freezing bar provided in this embodiment as those in the first, second and third embodiments are not described here, and only different points will be described below.

Fig. 9 is a plan view of a freezing bar according to a fourth embodiment of the present invention, and fig. 10 is a plan view of a body of the freezing bar according to the fourth embodiment of the present invention. As shown in fig. 9 and 10, the present embodiment is different from the third embodiment in that: the section of the tip region 211 of the rod carrier body 200 from the distal end to the proximal end is triangular, and the bottom side of the triangle is connected with the distal end of the embryo carrying region 212. The tip region 211 is triangular and can guide the slide 210, so that the protective sleeve 100 can be further prevented from colliding with the slide 210 to prevent the gamete/embryo solution on the slide 210 from falling off. Fig. 11 is a top view of a protective sleeve according to a fourth embodiment of the present invention. As shown in fig. 9 and 11, the freezing bar further comprises a plug 150, the distal end of the protecting sleeve 100 has a second opening 130, and the plug 150 closes the second opening 130.

Further, the plug 150 is a metal plug, and more preferably, the plug 150 is a stainless steel plug.

Further, the distal end region of the plug 150 is hemispherical and is located outside the protective sleeve 100, and the proximal end region of the plug 150 is cylindrical and is in interference fit with the distal end region inside the protective sleeve 100 to close the second opening 130.

It should be appreciated that the proximal end of the protection sleeve 100 has a first opening 140 and the distal end of the protection sleeve 100 has a second opening 130. it is to be understood that the protection sleeve 100 is formed by a sleeve 160 and a plug 150 for plugging the distal end of the sleeve 160. As such, the protection sleeve 100 is simpler in structure and simpler to manufacture. Meanwhile, the plug 150 can be reused, which is also beneficial to reducing the cost of the protective sleeve 100. In addition, the sleeve 160 may have a plurality of colors, the color of the sleeve 160 may serve as marking information, and the plug 150 and the sleeve 160 may have physical marks such as colors or marks for marking information.

Accordingly, in the method for manufacturing the freezing slide rod, the distal end of the protection sleeve 100 is provided with the second opening 130, and before the slide rod body 200 is placed in the protection sleeve 100 through the first opening 140, the method further comprises the following steps:

a plug 150 is provided for plugging the second opening 130.

EXAMPLE five

The same portions of the freezing bar provided in this embodiment as those in the first, second, third and fourth embodiments will not be described here, and only different points will be described below.

Fig. 12 is a plan view of the freezing bar in this embodiment. As shown in fig. 12, the present embodiment is different from the fourth embodiment in that: the sealing unit is a sealing member 400, and the sealing member 400 is detachably connected to the first opening 140 and is used for sealing the first opening 140.

It will be appreciated that the closure has a smaller volume and a lower cost. By replacing the handle 300 with a closure to close the first opening 140, the cost of the freeze bar may be reduced.

Accordingly, in the method for manufacturing the freezing slide bar, after the slide bar body 200 is placed in the protection sleeve 100 through the first opening 140, the method further comprises the following steps:

a closure is provided with which the first opening 140 is closed.

EXAMPLE six

The same portions of the freezing bar provided in this embodiment as those in the first, second, third, fourth and fifth embodiments will not be described here, and only different points will be described below.

The present embodiment is different from the fifth embodiment in that: the sealing unit is a thermal shrinkage port disposed at the proximal end of the first opening 140, and the proximal end of the protection sleeve 100 is closed by heating the thermal shrinkage port.

Accordingly, in the method for manufacturing the freezing slide bar, as shown in fig. 6, after the slide bar body 200 is placed in the protection sleeve 100 through the first opening 140, the method further comprises the following steps:

the first opening 140 is closed by heating the heat shrink.

In summary, embodiments of the present invention provide a freeze carrier bar that includes a protective sleeve and a carrier bar body. Wherein the proximal end of the protection sleeve has a first opening. The slide glass slide rod is characterized in that the slide glass rod body is positioned in the protective sleeve and is provided with a connecting section and a slide glass, the slide glass is positioned at the far end of the connecting section, the bearing surface of the slide glass is an arc surface, the connecting section is a tubular slide glass rod body and is provided with the connecting section and the slide glass, the bearing surface of the slide glass is an arc surface, and the connecting section is tubular.

In the invention, the connecting section of the carrying rod body and the carrying sheet are integrated into a whole structure, so that the carrying sheet is not easy to bend. In addition, the freezing pole that carries still includes the handle, the handle is first connecting portion, second connecting portion and handheld portion respectively from the distal end to the near-end. The first connecting part is in interference fit with the connecting section to be fixedly connected, and the freezing carrying rod is fixed relative to the handle and the carrying sheet in a dispensing or welding mode. In addition, the bearing surface which is in an arc-shaped surface provides a larger contact area for liquid drops of the gamete solution or the embryo solution and liquid nitrogen, so that the heat transfer efficiency can be accelerated, and the gamete/embryo has higher freezing efficiency. In addition, first connecting portion with linkage segment interference fit is with fixed connection for carry the pole body and can dismantle with the handle and link to each other, the doctor can select the handle of different length according to self use habit, with the length of adjustment freezing year pole.

Correspondingly, the invention also provides a manufacturing method of the freezing carrying rod, which comprises the following steps: providing a pipe, and cutting the pipe to obtain a carrying rod body, wherein the carrying rod body is provided with a connecting section and a carrying sheet, the carrying surface of the carrying sheet is an arc-shaped surface, and the connecting section is tubular; providing a protective sleeve, wherein the proximal end of the protective sleeve is provided with a first opening, and placing the carrier rod body in the protective sleeve through the first opening. The method has the advantages of lower manufacturing difficulty and contribution to reducing the manufacturing cost.

The above description is only a preferred embodiment of the present invention, and does not limit the present invention in any way. It will be understood by those skilled in the art that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.