阅读说明：本技术 用于导管的高压发生电路及消融工具 (High voltage generating circuit for catheter and ablation tool ) 是由 赵成刚 于 2021-08-10 设计创作，主要内容包括：本发明公开了一种用于导管的高压发生电路及消融工具,其中,高压发生电路包括：N个电压变换单元、N个储能单元、电压调整单元和控制单元。N个电压变换单元的输入端并联后与总输入端相连,N个电压变换单元的输出端串联后与总输出端相连,N个储能单元与N个电压变换单元一一对应；电压调整单元的输入端与每个电压变换单元的输出端相连,电压调整单元的输出端与总输出端相连；控制单元与N个电压变换单元和电压调整单元相连,以调整总输出端的输出电压为目标电压。由此,通过多个输入并联输出串联的电压变换单元能够实现输出电压快速切换至目标电压,同时扩宽了电压的输出范围,从而提高了脉冲电场消融技术在心律失常治疗上的应用前景。(The invention discloses a high voltage generating circuit and an ablation tool for a catheter, wherein the high voltage generating circuit comprises: the device comprises N voltage conversion units, N energy storage units, a voltage adjusting unit and a control unit. The input ends of the N voltage conversion units are connected in parallel and then connected with the main input end, the output ends of the N voltage conversion units are connected in series and then connected with the main output end, and the N energy storage units correspond to the N voltage conversion units one to one; the input end of the voltage adjusting unit is connected with the output end of each voltage conversion unit, and the output end of the voltage adjusting unit is connected with the total output end; the control unit is connected with the N voltage conversion units and the voltage adjusting unit to adjust the output voltage of the total output end to be the target voltage. Therefore, the voltage conversion units with the input connected in parallel and the output connected in series can realize the quick switching of the output voltage to the target voltage, and simultaneously widen the output range of the voltage, thereby improving the application prospect of the pulsed electric field ablation technology in the treatment of arrhythmia.)

1. A high voltage generating circuit for a catheter, comprising:

the input ends of the N voltage conversion units are connected with the total input end of the high-voltage generating circuit after being connected in parallel, the output ends of the N voltage conversion units are connected with the total output end of the high-voltage generating circuit after being connected in series, the N energy storage units correspond to the N voltage conversion units one to one, each energy storage unit is connected between the output ends of the corresponding voltage conversion units, each voltage conversion unit in the N voltage conversion units is used for performing voltage conversion on the input voltage of the total input end and charging the corresponding energy storage unit, and N is an integer greater than 1;

the input end of the voltage adjusting unit is connected with the output end of each voltage conversion unit, and the output end of the voltage adjusting unit is connected with the total output end and used for controlling the on-off between the output end of each voltage conversion unit and the total output end;

and the control unit is connected with the N voltage conversion units and the voltage adjustment unit and is used for acquiring a target voltage of the high-voltage generation circuit and controlling the N voltage conversion units and the voltage adjustment unit according to the target voltage so as to adjust the output voltage of the total output end to be the target voltage.

2. The high voltage generating circuit for a catheter according to claim 1, wherein the N voltage transforming units cooperate with the N energy storage units to form N voltage intervals, the control unit being specifically configured to: and acquiring a voltage interval corresponding to the target voltage, and controlling the N voltage conversion units and the voltage adjustment unit according to the voltage interval corresponding to the target voltage.

3. The high voltage generating circuit for a conduit of claim 1, further comprising:

the input end of the current adjusting unit is connected with the output end of the voltage adjusting unit, and the output end of the current adjusting unit is connected with the total output end and used for adjusting the output current of the total output end;

the control unit is further connected with the current adjusting unit and used for obtaining target power of the high-voltage generating circuit and controlling the N voltage converting units, the voltage adjusting unit and the current adjusting unit according to the target power so as to adjust output voltage and output current of the total output end to obtain the target power.

4. The high voltage generating circuit for a catheter according to any one of claims 1-3, wherein the N energy storage units are identical in structure and each comprises an energy storage capacitor connected in parallel between the output terminals of the respective voltage transforming units.

5. The high voltage generating circuit for a catheter according to any one of claims 1-3, wherein the voltage adjusting unit comprises: the N first switches are in one-to-one correspondence with the N voltage conversion units, and each first switch is connected in series between the output end of the corresponding voltage conversion unit and the total output end.

6. The high voltage generating circuit for a conduit of claim 5, wherein the N first switches are identical in structure and each first switch comprises:

one end of a switch of the relay is connected with the output end of the corresponding voltage conversion unit, and one end of a coil of the relay is connected with a preset power supply;

the anode of the voltage-stabilizing tube is connected with the other end of the coil of the relay, and the cathode of the voltage-stabilizing tube is connected with one end of the coil of the relay;

the anode of the second diode is connected with the other end of the switch of the relay, and the cathode of the second diode is connected with the total output end;

and the first end of the second switch tube is connected with the other end of the coil of the relay, the second end of the second switch tube is grounded, and the control end of the second switch tube is connected with the control unit.

7. The high voltage generating circuit for a catheter according to claim 3, wherein the current regulating unit comprises M current regulating branches connected in parallel, M being an integer greater than 1, and each current regulating branch comprises:

one end of the current-limiting resistor is connected with the output end of the voltage adjusting unit;

and one end of the current limiting switch is connected with the other end of the current limiting resistor, and the other end of the current limiting switch is connected with the main output end.

8. The high voltage generating circuit for a catheter according to any one of claims 1-3, wherein the N voltage transforming units have the same structure and each voltage transforming unit comprises a switch tube for voltage conversion, and part or all of the N voltage transforming units share the switch tube.

9. The high voltage generating circuit for a conduit of claim 8, wherein each voltage conversion unit is a flyback conversion circuit, a forward conversion circuit, an LLC resonant circuit, a boost circuit, or a bridge circuit.

10. The high voltage generating circuit for a catheter according to any one of claims 1-3, wherein the control unit comprises one or more control chips, wherein when the control unit comprises one control chip, the N voltage converting units share the control chip; when the control unit comprises a plurality of control chips, part of the N voltage conversion units share one control chip or each voltage conversion unit corresponds to one control chip.

11. An ablation instrument comprising a catheter and the high voltage generation circuit for a catheter of any one of claims 1-10.

Technical Field

The invention relates to the technical field of pulsed electric field ablation, in particular to a high-voltage generating circuit for a catheter and an ablation tool.

Background

The ablation energy in the catheter ablation technology adopted for treating arrhythmia at present is mainly radio frequency energy and is assisted by freezing energy, and the two ablation modes have certain superiority in treating arrhythmia and have corresponding limitations, for example, the ablation energy has no selectivity for damaging tissues in an ablation area, and certain damage can be caused to adjacent esophagus, coronary artery, phrenic nerve and the like depending on the adhesion force of a catheter, so that the related technology of finding a quick, safe and efficient ablation energy to complete and achieve persistent pulmonary vein isolation without damaging adjacent tissues becomes a hotspot of research.

Pulsed electric field ablation is a new type of ablation using pulsed electric field as energy, and is gaining attention as a non-thermal ablation technique in clinical application. The pulsed electric field ablation technology is mainly characterized in that a high-voltage pulsed electric field with the pulse width of millisecond, microsecond or even nanosecond is generated, extremely high energy is released in a short time, and a cell membrane, even intracellular organelles such as endoplasmic reticulum, mitochondria, cell nucleus and the like can generate a large number of irreversible micropores, so that apoptosis of pathological cells is caused, and the expected treatment purpose is achieved. However, as a new energy ablation technology, the pulsed electric field ablation technology faces the defect that the output voltage of the high voltage generating circuit cannot be rapidly switched to the target voltage, thereby limiting the clinical application of the pulsed electric field ablation technology.

Disclosure of Invention

The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, a first object of the present invention is to provide a high voltage generating circuit for a catheter, which can realize fast switching of an output voltage to a target voltage through a plurality of voltage converting units connected in series with input and output in parallel, and simultaneously widen an output range of the voltage, thereby improving application prospects of pulsed electric field ablation technology in arrhythmia treatment.

A second object of the invention is to propose an ablation instrument.

In order to achieve the above object, a first embodiment of the present invention provides a high voltage generating circuit for a catheter, including: the input ends of the N voltage conversion units are connected with the total input end of the high-voltage generating circuit after being connected in parallel, the output ends of the N voltage conversion units are connected with the total output end of the high-voltage generating circuit after being connected in series, the N energy storage units correspond to the N voltage conversion units one by one, each energy storage unit is connected between the output ends of the corresponding voltage conversion units, each voltage conversion unit in the N voltage conversion units is used for performing voltage conversion on the input voltage of the total input end and charging the corresponding energy storage unit, and N is an integer greater than 1; the input end of the voltage adjusting unit is connected with the output end of each voltage conversion unit, and the output end of the voltage adjusting unit is connected with the total output end and used for controlling the on-off between the output end of each voltage conversion unit and the total output end; and the control unit is connected with the N voltage conversion units and the voltage adjustment unit and is used for acquiring the target voltage of the high-voltage generation circuit and controlling the N voltage conversion units and the voltage adjustment unit according to the target voltage so as to adjust the output voltage of the total output end to be the target voltage.

According to the high-voltage generating circuit for the catheter, the input ends of the voltage conversion units are connected in parallel and then connected with the total input end of the high-voltage generating circuit, the output ends of the voltage conversion units are connected in series and then connected with the total output end of the high-voltage generating circuit, the voltage adjusting unit is connected between the output end and the total output end of each voltage conversion unit and used for controlling the on-off of the output end and the total output end of each voltage conversion unit, and the control unit is connected with each voltage conversion unit and the voltage adjusting unit and used for controlling the voltage conversion units and the voltage adjusting unit to adjust the output voltage of the total output end to be the target voltage. Therefore, the voltage conversion units with the input connected in parallel and the output connected in series can realize the quick switching of the output voltage to the target voltage, and simultaneously widen the output range of the voltage, thereby improving the application prospect of the pulsed electric field ablation technology in the treatment of arrhythmia.

According to an embodiment of the present invention, the N voltage conversion units cooperate with the N energy storage units to form N voltage intervals, and the control unit is specifically configured to: and acquiring a voltage interval corresponding to the target voltage, and controlling the N voltage conversion units and the voltage adjustment unit according to the voltage interval corresponding to the target voltage.

According to an embodiment of the present invention, the high voltage generating circuit for a catheter further comprises: the input end of the current adjusting unit is connected with the output end of the voltage adjusting unit, and the output end of the current adjusting unit is connected with the total output end and used for adjusting the output current of the total output end; the control unit is also connected with the current adjusting unit and used for obtaining the target power of the high-voltage generating circuit and controlling the N voltage converting units, the voltage adjusting unit and the current adjusting unit according to the target power so as to adjust the output voltage and the output current of the total output end to obtain the target power.

According to one embodiment of the invention, the N energy storage units have the same structure, and each energy storage unit comprises an energy storage capacitor, and the energy storage capacitors are connected in parallel between the output ends of the corresponding voltage conversion units.

According to an embodiment of the present invention, a voltage adjusting unit includes: the N first switches correspond to the N voltage conversion units one by one, and each first switch is connected between the output end of the corresponding voltage conversion unit and the total output end in series.

According to one embodiment of the present invention, the N first switches are identical in structure and each of the first switches includes: one end of a switch of the relay is connected with the output end of the corresponding voltage conversion unit, and one end of a coil of the relay is connected with a preset power supply; the anode of the voltage-stabilizing tube is connected with the other end of the coil of the relay, and the cathode of the voltage-stabilizing tube is connected with one end of the coil of the relay; the anode of the second diode is connected with the other end of the switch of the relay, and the cathode of the second diode is connected with the total output end; and the first end of the second switch tube is connected with the other end of the coil of the relay, the second end of the second switch tube is grounded, and the control end of the second switch tube is connected with the control unit.

According to an embodiment of the present invention, the current adjusting unit includes M current adjusting branches connected in parallel, M is an integer greater than 1, and each current adjusting branch includes: one end of the current-limiting resistor is connected with the output end of the voltage adjusting unit; and one end of the current limiting switch is connected with the other end of the current limiting resistor, and the other end of the current limiting switch is connected with the main output end.

According to an embodiment of the invention, the N voltage conversion units have the same structure, and each voltage conversion unit includes a switch tube for voltage conversion, and part or all of the N voltage conversion units share the switch tube.

According to an embodiment of the present invention, each voltage conversion unit is a flyback conversion circuit, a forward conversion circuit, an LLC resonant circuit, a boost circuit, or a bridge circuit.

According to one embodiment of the present invention, the control unit includes one or more control chips, wherein, when the control unit includes one control chip, the N voltage converting units share the control chip; when the control unit comprises a plurality of control chips, part of the N voltage conversion units share one control chip or each voltage conversion unit corresponds to one control chip.

In order to achieve the above object, a second aspect of the present invention provides an ablation instrument, including a high voltage generation circuit for a catheter as in the first aspect.

According to the ablation tool provided by the embodiment of the invention, through the high-voltage generating circuit for the catheter, the output voltage can be rapidly switched to the target voltage through the voltage conversion units with the input connected in parallel and the output connected in series, and the output range of the voltage is widened, so that the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved.

Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.

Drawings

FIG. 1 is a schematic diagram of a high voltage generation circuit for a catheter according to one embodiment of the present invention;

FIG. 2 is a schematic diagram of a high voltage generation circuit for a catheter according to another embodiment of the present invention;

FIG. 3 is a schematic diagram of a high voltage generation circuit for a catheter according to yet another embodiment of the present invention;

FIG. 4 is a schematic diagram of a first switch of a high voltage transmit circuit for a conduit according to one embodiment of the present invention;

FIG. 5 is a schematic diagram of a high voltage generation circuit for a catheter according to yet another embodiment of the present invention;

fig. 6 is a schematic structural view of an ablation instrument in accordance with an embodiment of the invention.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.

The high voltage generating circuit for a catheter and an ablation instrument according to embodiments of the present invention will be described with reference to the accompanying drawings.

Fig. 1 is a schematic structural diagram of a high voltage generating circuit for a catheter according to an embodiment of the present invention, and referring to fig. 1, the high voltage generating circuit may include: n voltage conversion units (N is an integer greater than 1), N energy storage units, a voltage adjustment unit 200, and a control unit 300.

The input ends of the N voltage conversion units are connected in parallel and then connected with the total input end of the high-voltage generating circuit, the output ends of the N voltage conversion units are connected in series and then connected with the total output end of the high-voltage generating circuit, the N energy storage units correspond to the N voltage conversion units one to one, each energy storage unit is connected between the output ends of the corresponding voltage conversion units, and each voltage conversion unit in the N voltage conversion units is used for performing voltage conversion on the input voltage of the total input end and charging the corresponding energy storage unit; the input end of the voltage adjusting unit 200 is connected with the output end of each voltage conversion unit, and the output end of the voltage adjusting unit 200 is connected with the total output end for controlling the on-off between the output end of each voltage conversion unit and the total output end; the control unit 300 is connected to the N voltage converting units and the voltage adjusting unit 200, and is configured to obtain a target voltage of the high voltage generating circuit, and control the N voltage converting units and the voltage adjusting unit 200 according to the target voltage, so as to adjust an output voltage of the total output terminal to be the target voltage.

Specifically, the voltage conversion unit and the energy storage unit may include a plurality of units, and the specific number may be selected according to actual use requirements. As a specific example, referring to fig. 1, the high voltage generation circuit may include four voltage transformation units (voltage transformation units 111, 121, 131, and 141, respectively) and four energy storage units (energy storage units 112, 122, 132, and 142, respectively). First input ends of the voltage conversion units 111, 121, 131 and 141 are connected and then connected with a total input positive terminal Vin of the high-voltage generation circuit; second input ends of the voltage conversion units 111, 121, 131 and 141 are connected and then connected with a total input negative end GND of the high voltage generation circuit; a first output end of the voltage conversion unit 111 is connected with one end of the corresponding energy storage unit 112 and a first input end of the voltage adjustment unit 200, and a second output end of the voltage conversion unit 111 is connected with the other end of the corresponding energy storage unit 112; a first output end of the voltage conversion unit 121 is connected to one end of the corresponding energy storage unit 122, a second input end of the voltage adjustment unit 200, and the other end of the energy storage unit 112, and a second output end of the voltage conversion unit 121 is connected to the other end of the corresponding energy storage unit 122; a first output end of the voltage conversion unit 131 is connected to one end of the corresponding energy storage unit 132, a third input end of the voltage adjustment unit 200, and the other end of the energy storage unit 122, and a second output end of the voltage conversion unit 131 is connected to the other end of the corresponding energy storage unit 132; a first output end of the voltage conversion unit 141 is connected to one end of the corresponding energy storage unit 142, a fourth input end of the voltage adjustment unit 200, and the other end of the energy storage unit 132, and a second output end of the voltage conversion unit 141 is connected to the other end of the corresponding energy storage unit 142 and a total output negative end GND of the high voltage generation circuit; the output terminal of the voltage regulation unit 200 is connected to the total output positive terminal Vout of the high voltage generation circuit. The voltage conversion units 111, 121, 131 and 141 respectively perform voltage conversion on the input voltage of the overall input terminal to charge the corresponding energy storage units 112, 122, 132 and 142. When the high voltage generating circuit operates, although the input terminals of the voltage converting units 111, 121, 131 and 141 are connected in parallel, the same operating voltage can be obtained, but since the output terminals of the voltage converting units 111, 121, 131 and 141 are connected in series, the voltages at the output terminals of the voltage converting units 141, 131, 121 and 111 will increase step by step, that is, the voltages at one ends of the energy storing units 142, 132, 122 and 112 increase step by step, that is, the voltages at D, C, B and a point in fig. 1 increase sequentially, for example, the voltage at a point D is the voltage of the energy storing unit 142, the voltage at a point C is the sum of the voltages of the energy storing units 142 and 132, and 122, the voltage at a point B is the sum of the voltages of the energy storing units 142, 132, 122 and 112.

The control unit 300 obtains a target voltage of the high voltage generating circuit, and controls the voltage converting units 111, 121, 131, 141 and the voltage adjusting unit 200 according to the target voltage, so as to quickly adjust the output voltage of the total output terminal as the target voltage. For example, assuming that the maximum voltage corresponding to each energy storage unit is 500V, the voltage adjustable range is 0-2000V, and when a target voltage of 2000V needs to be obtained, four voltage conversion voltages can be controlled to simultaneously work to charge the corresponding energy storage units until the target voltage of 2000V is reached, compared with the case that only one voltage conversion unit is adopted, the speed of obtaining the output voltage is effectively improved. When the target voltage is switched from 2000V to 500V, the four energy storage units can be discharged simultaneously, and compared with the situation that only one energy storage unit is adopted, the discharging time is shorter, so that the rapid switching of the output voltage can be realized; or, the control unit 300 directly controls the voltage adjustment unit 200, and controls the on/off between the first output terminals of the voltage conversion units 111, 121, 131, and 141 and the total output positive terminal Vout to realize the fast switching of the output voltage of the total output terminal, for example, the control unit 300 directly controls the output terminal of the voltage conversion unit 141 to communicate with the total output positive terminal Vout, so that the output voltage of the output terminal directly reaches the target voltage 500V, and discharge is not needed, thereby realizing the fast switching of the output voltage and saving electric energy. Moreover, a wide voltage range of 0-2000V can be realized, and only one voltage conversion unit is adopted, so that the voltage range of 0-2000V cannot be realized, or even the voltage conversion can be realized by a transformer and a high-power transistor which need large volume, and the voltage conversion unit not only can realize wide-range voltage output, but also can adopt smaller components because the output voltage is divided into N parts, which is equivalent to low-voltage control.

Therefore, the voltage conversion units with the input connected in parallel and the output connected in series can realize the rapid switching of the output voltage, and widen the output range of the voltage, thereby improving the application prospect of the pulsed electric field ablation technology in the treatment of arrhythmia.

In some embodiments, the N voltage transforming units cooperate with the N energy storage units to form N voltage intervals, and the control unit 300 is specifically configured to: and acquiring a voltage interval corresponding to the target voltage, and controlling the N voltage conversion units and the voltage adjustment unit 200 according to the voltage interval corresponding to the target voltage.

Specifically, as shown in fig. 1, the four voltage transforming units and the four energy storing units cooperate to form four voltage intervals, and assuming that the highest voltages of the points A, B, C and D are 2000V, 1500V, 1000V and 500V, the four voltage intervals are [0V,500V ], [500V,1000V ], [1000V,1500V ] and [1500V,2000V ].

If the target voltage is switched from 2000V to 500V, the target voltage obtained by the control unit 300 is 500V, and the corresponding voltage interval is [0V,500V ], at this time, the control unit 300 can directly control the voltage adjustment unit 200 to connect the output terminal of the voltage conversion unit 141 with the total output terminal Vout, and the output terminals of the other voltage conversion units and the total output positive terminal Vout are in a disconnected state, at this time, the voltage of 500V can be obtained at the total output terminal, compared with a scheme with only one voltage conversion unit and one energy storage unit, the voltage is not required to be output after 500V is reduced from 2000V, and the switching speed of the output voltage is greatly improved.

For another example, if the target voltage is switched from 2000V to 700V, the target voltage obtained by the control unit 300 is 700V, and the corresponding voltage interval is [500V,1000V ], at this time, the control unit 300 may control the voltage converting units 141 and 131 to charge the corresponding energy storage units, so that the voltage at the point C reaches 700V, and then control the voltage adjusting unit 200 to connect the output terminal of the voltage converting unit 131 with the total output terminal Vout, and disconnect the output terminals of the other voltage converting units from the total output positive terminal Vout, at this time, the voltage at 700V may be obtained at the total output terminal; or, the control unit 300 controls the voltage converting units 141 and 131 to charge the corresponding energy storing units, so that the voltage at the point C reaches 1000V, then the energy storing unit 132 discharges 300V until the voltage at the point C is 700V, and finally the voltage adjusting unit 200 is controlled to connect the output terminal of the voltage converting unit 131 with the total output terminal Vout, and the output terminals of the other voltage converting units and the total output positive terminal Vout are in a disconnected state, so that the voltage of 700V can be obtained at the total output terminal.

It should be noted that, this is merely an exemplary illustration, and other switching manners may also be adopted in practical applications, and may be specifically determined according to the voltage of each energy storage unit before switching, the target voltage after switching, and the voltage interval in which the target voltage is located.

For example, if the target voltage is switched from 2000V to 300V, the target voltage obtained by the control unit 300 is 300V, and the corresponding voltage interval is [0V,500V ], at this time, the control unit 300 controls the energy storage unit 142 to discharge, so as to discharge the voltages at the two ends from 500V to 300V, and then controls the voltage adjustment unit 200 to connect the output end of the voltage conversion unit 141 to the total output positive terminal Vout, and the output ends of the other voltage conversion units and the total output positive terminal Vout are in the disconnected state, so that the voltage of 300V can be obtained at the total output end, compared with a scheme with only one voltage conversion unit and one energy storage unit, the voltage does not need to be reduced by 300V from 2000V before being output, thereby greatly improving the switching speed of the output voltage.

Further, assuming that the target voltage is switched from 300V to 700V, the target voltage obtained by the control unit 300 is 700V, the corresponding voltage interval is [500V,1000V ], at this time, since the 500V stored in the energy storage unit 132 is not discharged, therefore, the voltage at point C is 800V, and the energy storage unit 142 and/or the energy storage unit 132 can be discharged at this time, so that the voltage at point C is 700V, the control unit 300 then controls the voltage regulating unit 200 such that the output terminal of the voltage converting unit 131 is connected to the total output plus terminal Vout, and the output ends of other voltage conversion units and the total output end Vout are in a disconnected state, and at the moment, 700V voltage can be obtained at the total output end, compared with a scheme with only one voltage conversion unit and one energy storage unit, the voltage conversion unit does not need to be charged from 300V to 700V, so that the output voltage switching speed is higher, and energy can be saved.

Further, assuming that the target voltage is switched from 700V to 1300V, the target voltage obtained by the control unit 300 is 1300V, and the corresponding voltage interval is [1000V,1500V ], at this time, since 500V stored in the energy storage unit 122 is not discharged, the voltage at the point B is 1200V, and at this time, the voltage conversion unit 141 and/or 131 is controlled to recharge 100V, so that the voltage at the point B can obtain 1300V. For other situations, the voltage of each energy storage unit before the target voltage is switched is obtained, the plurality of voltage conversion units are controlled according to the voltage of each energy storage unit and the target voltage, and the voltage adjustment unit is controlled according to the voltage interval corresponding to the target voltage, so that the output voltage can be switched quickly.

In some embodiments, as shown in fig. 2, the high voltage generation circuit for a catheter further comprises: the input end of the current adjusting unit 400 is connected with the output end of the voltage adjusting unit 200, and the output end of the current adjusting unit 400 is connected with the total output positive terminal Vout and used for adjusting the output current of the total output positive terminal Vout; the control unit 300 is further connected to the current adjusting unit 400, and is configured to obtain a target power of the high voltage generating circuit, and control the N voltage converting units, the voltage adjusting unit 200, and the current adjusting unit 400 according to the target power, so as to adjust the output voltage and the output current of the total output positive terminal Vout to obtain the target power.

Specifically, the control unit 300 may control the current adjusting unit 400, and change the output current of the total output terminal by changing the size of the resistor built in the current adjusting unit 400, for example, the current adjusting unit 400 may be a variable resistor with steplessly adjustable resistance, and the output current may be directly adjusted to the required current by changing the resistance value of the variable resistor, so as to implement fast switching of different output currents. Further, the control unit 300 may implement flexible adjustment of the output voltage, the output current, and the output power by controlling the N voltage converting units, the voltage adjusting unit 200, and the current adjusting unit 400. Specifically, when only the target power is required, the output voltage and/or the output current of the total output terminal can be adjusted in the manner described above, so that the output power reaches the target power; when both the target power and the target voltage are required, the output voltage of the total output terminal can be adjusted in the above manner to reach the target voltage, and then the output current is changed by adjusting the internal resistance of the current adjusting unit 400, so that the output power reaches the target power.

It should be noted that the control unit 300 may also control the N voltage converting units, the voltage adjusting unit 200, and the current adjusting unit 400 to achieve fast switching of the target power. For example, when only the target power is required, assuming that the target power is 1000w and the target voltage before switching is 800V, if the output current can reach 1.25A, the target power can be quickly adjusted by adjusting the output current, and compared with the scheme that only one voltage conversion unit and corresponding energy storage unit are provided, the process of adjusting the output voltage is omitted, and the adjustment of the output voltage involves a charge and discharge process, so that the adjustment speed of the target power with the current adjustment unit 400 is faster and more energy-saving. In the case that both the target power and the target voltage are required, the embodiment can realize the output of any target voltage and any target power within the range, and the output of any target voltage and any target power may not have a constraint relationship between the target power and the target power, for example, only one voltage conversion unit and a corresponding energy storage unit are provided, and the target power and the target voltage are in a corresponding relationship, so that flexible adjustment cannot be realized.

Therefore, the fast and flexible switching among different output voltages, output currents and output power can be realized through the voltage conversion units, the voltage adjustment units and the current adjustment units, meanwhile, as the output voltages are divided into N parts, which is equivalent to low-voltage control, each voltage conversion unit can be realized by adopting smaller components, and the application prospect of the pulse electric field ablation technology on arrhythmia treatment is improved.

In some embodiments, the control unit 300 includes one or more control chips, wherein, when the control unit 300 includes one control chip, the N voltage converting units share the control chip; when the control unit 300 includes a plurality of control chips, a part of the N voltage conversion units shares one control chip or each voltage conversion unit corresponds to one control chip.

Specifically, the control chip in the control unit 300 may include one or more control chips, each control chip may control one voltage conversion unit, and may also control a plurality of voltage conversion units, and the specific number of the control chips and the number of the voltage conversion units controlled by each control chip may be selected according to actual use requirements. As a specific example, referring to fig. 3, the control unit 300 of the high voltage generating circuit includes two control chips, which are a control chip IC Controller-1 and a control chip IC Controller-2, respectively, each control chip controls two voltage converting units at the same time, and the same control chip has the same switching period, so that the voltage converting units under the control of the same control chip can output converted voltage more flexibly, and the staggered on-off of different control chips can be realized by controlling the on-off time of different control chips, thereby realizing the input of the minimum current ripple and the minimum voltage ripple, and further inputting the minimum capacitor.

In some embodiments, the N voltage converting units have the same structure, and each voltage converting unit includes a switching tube for performing voltage conversion, and some or all of the N voltage converting units share the switching tube.

That is to say, N voltage conversion units may share one or more switching tubes to perform voltage conversion through one or more switching tubes, and the specific number of switching tubes and the number of voltage conversion units controlled by each switching tube may be selected according to actual use requirements. As a specific example, with reference to fig. 3, the high voltage generating circuit includes two switching tubes, and each switching tube simultaneously controls two voltage converting units, and when the control unit 300 controls on/off of the switching tube, the voltage converting units corresponding to the switching tubes can be controlled to be turned on/off, so that cost and board layout size can be saved.

In some embodiments, each voltage conversion unit is a flyback conversion circuit, a forward conversion circuit, an LLC resonant circuit, a boost circuit, or a bridge circuit. That is to say, the voltage conversion unit in this application can be flyback conversion circuit, forward conversion circuit, LLC resonant circuit, exempt from circuit or bridge circuit etc. and guarantee that the type of voltage conversion unit is unanimous in the use, specifically adopt which kind of mode can select to set up according to actual demand.

In some embodiments, as shown in fig. 3, a flyback converter circuit includes: the circuit comprises a transformer (such as T1), a first switching tube (such as Q1), a first diode (such as D1) and a filter capacitor (such as C1), wherein one end of a primary winding of the transformer (such as T1) is connected with a total input positive terminal Vin; a first end of a first switch tube (for example, Q1) is connected to the other end of the primary winding of the transformer (for example, T1), a second end of the first switch tube (for example, Q1) is grounded GND, and a control end of the first switch tube (for example, Q1) is connected to the control unit 300; the anode of the first diode (e.g., D1) is connected to one end of the secondary winding of the transformer (e.g., T1); a filter capacitor (e.g., C1) is connected in parallel between the output terminals of the corresponding voltage conversion units, one end of the filter capacitor (e.g., C1) is connected to the cathode of the first diode (e.g., D1), and the other end of the filter capacitor (e.g., C1) is connected to the other end of the secondary winding of the transformer (e.g., T1).

Optionally, a first resistor (e.g., R1) is further connected in series between the second end of the first switch tube (e.g., Q1) and ground, and a connection point between the first resistor (e.g., R1) and the second end of the first switch tube (e.g., Q1) is connected to the control unit 300.

Optionally, the N energy storage units have the same structure, and each energy storage unit includes an energy storage capacitor, and the energy storage capacitors (e.g., C5) are connected in parallel between the output ends of the corresponding voltage conversion units.

The following description will be given taking as an example that each of the voltage conversion circuits shown in fig. 3 is a flyback conversion circuit. In fig. 3, the control unit 300 includes two control chips, each of which simultaneously controls two flyback converters, and each of the two flyback converters shares a switch tube.

Specifically, referring to fig. 3, the first flyback conversion circuit includes a transformer T1, a first switch Q1, a first diode D1 and a filter capacitor C1, the second flyback conversion circuit includes a transformer T2, a first switch Q2, a first diode D2 and a filter capacitor C2, the third flyback conversion circuit includes a transformer T3, a first switch Q3, a first diode D3 and a filter capacitor C3, and the fourth flyback conversion circuit includes a transformer T4, a first switch Q4, a first diode D4 and a filter capacitor C4. One end of primary windings of the transformers T1, T2, T3 and T4 is connected with a total input positive terminal Vin, a first end of a first switching tube Q1 is connected with the other ends of the primary windings of the transformers T1 and T2, and a first end of a first switching tube Q2 is connected with the other ends of the primary windings of the transformers T3 and T4; the second ends of the first switching tube Q1 and the first switching tube Q2 are grounded, the control end of the first switching tube Q1 is connected with the control chip IC Controller-1, and the control end of the first switching tube Q2 is connected with the control chip IC Controller-2; anodes of the first diodes D1, D2, D3 and D4 are connected to one end of the secondary windings of the transformers T1, T2, T3 and T4, respectively; filter capacitors C1, C2, C3 and C4 are connected in parallel between output terminals of the corresponding voltage converting units, one ends of the filter capacitors C1, C2, C3 and C4 are respectively connected to cathodes of the first diodes D1, D2, D3 and D4, the other ends of the filter capacitors C1, C2, C3 and C4 are respectively connected to the other ends of secondary windings of the transformers T1, T2, T3 and T4, and a secondary winding of the transformer T1 is grounded. A first resistor R1 is further connected in series between the second end of the first switch tube Q1 and the ground, a connection point between the first resistor R1 and the second end of the first switch tube Q1 is connected with the control chip ICController-1, a first resistor R2 is further connected in series between the second end of the first switch tube Q2 and the ground, and a connection point between the first resistor R2 and the second end of the first switch tube Q2 is connected with the control chip IC Controller-2. Each energy storage unit comprises an energy storage capacitor, and the energy storage capacitors C5, C6, C7 and C8 are respectively connected in parallel between the output ends of the corresponding flyback conversion circuits.

When the high-voltage generating circuit works, the primary windings of the transformers T1, T2, T3 and T4 obtain the same working voltage from the total input positive terminal Vin, when the control unit 300 controls the first switching tubes Q1 and Q2 to be conducted, the currents in the primary windings of the transformers T1, T2, T3 and T4 and the magnetic field in the magnetic core are increased, energy is stored in the magnetic core, because the voltages generated in the secondary windings of the transformers T1, T2, T3 and T4 are opposite, the first diodes D1, D2, D3 and D4 are in a reverse bias state and cannot be conducted, and at the moment, the voltages and currents are provided to the load by the energy storage capacitors C5, C6, C7 and C8; when the control unit 300 controls the first switching tubes Q1 and Q2 to be switched off, the current in the primary winding is 0, and at the same time, the magnetic field in the magnetic core begins to drop, a forward voltage is induced on the secondary winding, at this time, the first diodes D1, D2, D3 and D4 are in a forward bias state, the switched-on current flows into the energy storage capacitors C5, C6, C7, C8 and the load, and the energy stored in the magnetic core is transferred to the energy storage capacitors C5, C6, C7, C8 and the load. Because the secondary winding of the transformer T1 is grounded, the output voltage of the first flyback conversion circuit is an absolute voltage VO, and so on, the output voltage of the second flyback conversion circuit is 2VO, the output voltage of the third flyback conversion circuit is 3VO, and the output voltage of the fourth flyback conversion circuit is 4VO, thereby realizing the gradual increase of the output voltage.

In some embodiments, the voltage adjusting unit 200 includes: the N first switches correspond to the N voltage conversion units one by one, and each first switch is connected between the output end of the corresponding voltage conversion unit and the total output positive end Vout in series.

Specifically, as shown with continued reference to fig. 3, the voltage adjusting unit 200 includes four first switches, i.e., first switches S1, S2, S3 and S4, respectively, and the first switches S1, S2, S3 and S4 are respectively connected in series between the output terminal of the corresponding voltage transforming unit and the current adjusting unit 400. The voltage output of the corresponding voltage conversion unit is realized by controlling the on and off of the first switches S1, S2, S3 and S4, and then the fast switching of the output voltage is realized, for example, the first switch S4 is closed, the rest of the first switches are open, the output voltage is VO, and if the first switch S1 is closed and the rest of the first switches are open, the output voltage is 4VO, so that the fast switching of the output voltage from VO to 4VO is realized, and the output voltage range is expanded.

Further, as shown in fig. 4, the N first switches have the same structure, and each first switch includes: the voltage regulator comprises a relay (such as K1), a voltage regulator tube (such as D5), a second diode (such as D9) and a second switch tube (such as Q3), wherein one end of a switch of the relay (such as K1) is connected with the output end of a corresponding voltage conversion unit, and one end of a coil of the relay (such as K1) is connected with a preset power supply V1; the anode of a voltage regulator tube (such as D5) is connected with the other end of the coil of the relay (such as K1), and the cathode of the voltage regulator tube (such as D5) is connected with one end of the coil of the relay (such as K1); an anode of the second diode (e.g., D9) is connected to the other end of the switch of the relay (e.g., K1), and a cathode of the second diode (e.g., D9) is connected to the current adjusting unit 400; a first terminal of a second switching tube (e.g., Q3) is connected to the other terminal of the coil of the relay (e.g., K1), a second terminal of the second switching tube (e.g., Q3) is grounded, and a control terminal of the second switching tube (e.g., Q3) is connected to the control unit 300.

Specifically, the following description will be given taking four first switches corresponding to four voltage conversion units as an example, and as shown in fig. 4, the first switch S1 includes a relay K1, a voltage regulator D5, a second diode D9, and a second switch Q3, the first switch S2 includes a relay K2, a voltage regulator D6, a second diode D10, and a second switch Q4, the first switch S3 includes a relay K3, a voltage regulator D7, a second diode D11, and a second switch Q5, and the first switch S4 includes a relay K4, a voltage regulator D8, a second diode D12, and a second switch Q6. One end of the switch of the relays K1, K2, K3 and K4 is connected with the output end of the corresponding voltage conversion unit respectively; one ends of coils of the relays K1, K2, K3 and K4 are connected with a preset power supply V1, anodes of voltage-stabilizing tubes D5, D6, D7 and D8 are connected with the other ends of the coils of the relays K1, K2, K3 and K4 respectively, and cathodes of the voltage-stabilizing tubes D5, D6, D7 and D8 are connected with one ends of the coils of the relays K1, K2, K3 and K4 respectively; anodes of the second diodes D9, D10, D11, and D12 are connected to the other ends of the switches of the relays K1, K2, K3, and K4, respectively, and cathodes of the second diodes D9, D10, D11, and D12 are connected to the current adjustment unit 400; first ends of the second switching tubes Q3, Q4, Q5 and Q6 are connected to the other ends of the coils of the relays K1, K2, K3 and K4, respectively, second ends of the second switching tubes Q3, Q4, Q5 and Q6 are all grounded, and control ends of the second switching tubes Q3, Q4, Q5 and Q6 are connected to the control unit 300, respectively.

When the high-voltage generating circuit works, the final output voltage of the total output positive terminal Vout can be controlled by controlling the on/off of the relays K1, K2, K3 and K4, for example, when the control unit 300 controls the second switching tube Q3 to be turned on and controls the other second switching tubes to be turned off, that is, the relay K1 is controlled to be turned on, and when the other relays are turned off, the output voltage of the total output positive terminal Vout is VO; when the control unit 300 controls the second switch tube Q4 to be turned on and controls the other second switch tubes to be turned off, namely the relay K2 is controlled to be closed, and when the other relays are turned off, the output voltage of the total output positive end Vout is 2 VO.

The second switching tubes Q3, Q4, Q5 and Q6 have a function of preventing voltage backflow generated by the mistaken opening of the upper-level relay, and even if the relays K1, K2, K3 and K4 are all opened, the high voltage 4VO correspondingly output by the relay K1 cannot flow back to other low voltage circuits to cause element burnout; and if the latter stage does not work, for example, relative to the relay K2, the relay K1 does not work, the relay K1 is equivalent to no load, and the rear end of the relay K1 is equivalent to suspension, so that the problem of voltage difference is avoided, that is, the relay with low voltage can be continuously used.

In some embodiments, as shown in fig. 5, the current adjusting unit 400 includes M current adjusting branches connected in parallel, and each current adjusting branch includes: a current limiting resistor (e.g., R11), one end of the current limiting resistor (e.g., R11) being connected to the output terminal of the voltage adjusting unit 200; and a current limiting switch (such as S11), wherein one end of the current limiting switch (such as S11) is connected with the other end of the current limiting resistor (such as R11), and the other end of the current limiting switch (such as S11) is connected with the positive end Vout of the total output.

Specifically, four current regulation branches are taken as an example for explanation, the first current regulation branch includes a current limiting resistor R11 and a current limiting switch S11, one end of the current limiting resistor R11 is connected to the output terminal of the voltage regulation unit 200, one end of the current limiting switch S11 is connected to the other end of the current limiting resistor R11, and the other end of the current limiting switch S11 is connected to the total output positive terminal Vout; the second current adjusting branch comprises a current-limiting resistor R22 and a current-limiting switch S22, one end of the current-limiting resistor R22 is connected with the output end of the voltage adjusting unit 200, one end of the current-limiting switch S22 is connected with the other end of the current-limiting resistor R22, and the other end of the current-limiting switch S22 is connected with the positive end Vout of the total output; the third current adjusting branch comprises a current-limiting resistor R33 and a current-limiting switch S33, one end of the current-limiting resistor R33 is connected with the output end of the voltage adjusting unit 200, one end of the current-limiting switch S33 is connected with the other end of the current-limiting resistor R33, and the other end of the current-limiting switch S33 is connected with the positive end Vout of the total output; the fourth current adjusting branch comprises a current limiting resistor R44 and a current limiting switch S44, one end of the current limiting resistor R44 is connected to the output terminal of the voltage adjusting unit 200, one end of the current limiting switch S44 is connected to the other end of the current limiting resistor R44, and the other end of the current limiting switch S44 is connected to the positive output terminal Vout. It should be noted that the resistances of the current limiting resistors R11, R22, R33, and R44 may be the same or different.

When the high-voltage generating circuit works, as shown in fig. 5, the first to fourth current adjusting branches are connected in parallel, the voltage obtained by each current adjusting branch is HV _ OUT, and the on-off states of different current adjusting branches are controlled by controlling the on-off of the current limiting switches in the current adjusting branches, so as to adjust the output current of the total output positive terminal Vout according to the current limiting resistors of the turned-on current adjusting branches. For example, when the voltage HV _ OUT input to the current adjusting unit 400 is unchanged, the current limiting switch S11 is closed, the remaining current limiting switches are opened, the output current is the ratio of the input voltage HV _ OUT to the current limiting resistor R11, the current limiting switches S11 and S22 are closed, the remaining current limiting switches are opened, and the output current is the ratio of the input voltage HV _ OUT in parallel with the current limiting resistors R11 and R22, so that the output current can be switched quickly, that is, the current limiting resistors with different resistance values are selected, or the current limiting resistors with different numbers are selected to play a role in adjusting the output current of the total output positive terminal Vout.

In summary, according to the high voltage generating circuit for a catheter of the embodiment of the present invention, the input ends of the voltage converting units are connected in parallel and then connected to the total input end of the high voltage generating circuit, the output ends of the voltage converting units are connected in series and then connected to the total output end of the high voltage generating circuit, the voltage adjusting unit is connected between the output end and the total output end of each voltage converting unit for controlling the on/off between the output end and the total output end of each voltage converting unit, and the control unit is connected to each voltage converting unit and the voltage adjusting unit for controlling the voltage converting units and the voltage adjusting unit to adjust the output voltage of the total output end as the target voltage. Therefore, the voltage conversion units with the input connected in parallel and the output connected in series can realize the rapid switching of the output voltage to the target voltage, and widen the output range of the voltage, thereby improving the application prospect of the pulsed electric field ablation technology in the treatment of arrhythmia.

Fig. 6 is a schematic structural diagram of an ablation instrument according to an embodiment of the present invention, and referring to fig. 6, the ablation instrument 1000 includes the high voltage generation circuit 100 for a catheter described above.

According to the ablation tool provided by the embodiment of the invention, through the high-voltage generating circuit for the catheter, the output voltage can be rapidly switched to the target voltage through the voltage conversion units with the input connected in parallel and the output connected in series, and the output range of the voltage is widened, so that the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved.

It should be noted that the logic and/or steps represented in the flowcharts or otherwise described herein, such as an ordered listing of executable instructions that can be considered to implement logical functions, can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device, such as a computer-based system, processor-containing system, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions. For the purposes of this description, a "computer-readable medium" can be any means that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of the computer-readable medium would include the following: an electrical connection (electronic device) having one or more wires, a portable computer diskette (magnetic device), a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium could even be paper or another suitable medium upon which the program is printed, as the program can be electronically captured, via for instance optical scanning of the paper or other medium, then compiled, interpreted or otherwise processed in a suitable manner if necessary, and then stored in a computer memory.

It should be understood that portions of the present invention may be implemented in hardware, software, firmware, or a combination thereof. In the above embodiments, the various steps or methods may be implemented in software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, any one or combination of the following techniques, which are known in the art, may be used: a discrete logic circuit having a logic gate circuit for implementing a logic function on a data signal, an application specific integrated circuit having an appropriate combinational logic gate circuit, a Programmable Gate Array (PGA), a Field Programmable Gate Array (FPGA), or the like.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.