阅读说明：本技术 用于导管的高压发生电路及消融工具 (High voltage generating circuit for catheter and ablation tool ) 是由 赵成刚 于 2021-08-10 设计创作，主要内容包括：本发明公开了一种用于导管的高压发生电路及消融工具,其中,高压发生电路包括：N个电压变换单元、N个储能单元、电压反馈单元、第一控制单元和第二控制单元,N个电压变换单元的输入端并联后与高压发生电路的总输入端相连,N个电压变换单元的输出端串联后与高压发生电路的总输出端相连,N个储能单元与N个电压变换单元一一对应；电压反馈单元的检测端与总输出端相连；第一控制单元与电压反馈单元的调整端相连；第二控制单元用于获取高压发生电路的目标电压,并调整总输出端的输出电压得到目标电压。由此,通过多个电压变换单元以及电压反馈单元能够实现输出电压快速切换至目标电压,提高了脉冲电场消融技术在心律失常治疗上的应用前景。(The invention discloses a high voltage generating circuit and an ablation tool for a catheter, wherein the high voltage generating circuit comprises: the input ends of the N voltage conversion units are connected in parallel and then connected with the total input end of the high-voltage generating circuit, the output ends of the N voltage conversion units are connected in series and then connected with the total output end of the high-voltage generating circuit, and the N energy storage units correspond to the N voltage conversion units one to one; the detection end of the voltage feedback unit is connected with the total output end; the first control unit is connected with the adjusting end of the voltage feedback unit; the second control unit is used for obtaining the target voltage of the high-voltage generating circuit and adjusting the output voltage of the total output end to obtain the target voltage. Therefore, the output voltage can be rapidly switched to the target voltage through the plurality of voltage conversion units and the voltage feedback unit, and the application prospect of the pulsed electric field ablation technology on arrhythmia treatment is improved.)

1. A high voltage generating circuit for a catheter, comprising:

the input ends of the N voltage conversion units are connected with the total input end of the high-voltage generating circuit after being connected in parallel, the output ends of the N voltage conversion units are connected with the total output end of the high-voltage generating circuit after being connected in series, the N energy storage units correspond to the N voltage conversion units one to one, each energy storage unit is connected between the output ends of the corresponding voltage conversion units, each voltage conversion unit in the N voltage conversion units is used for performing voltage conversion on the input voltage of the total input end and charging the corresponding energy storage unit, and N is an integer greater than 1;

the detection end of the voltage feedback unit is connected with the total output end and is used for detecting the output voltage of the total output end to obtain a feedback voltage and adjusting the feedback voltage;

the first control unit is connected with the adjusting end of the voltage feedback unit and is used for controlling the voltage feedback unit to adjust the feedback voltage;

and the second control unit is connected with the output ends of the N voltage conversion units and the voltage feedback unit and is used for acquiring the target voltage of the high-voltage generating circuit and controlling the N voltage conversion units according to the target voltage and the adjusted feedback voltage so as to adjust the output voltage of the total output end to obtain the target voltage.

2. The high voltage generating circuit for a catheter according to claim 1, wherein the voltage feedback unit comprises:

one end of the voltage sampling subunit is connected with the total output end;

and one end of the voltage adjusting subunit is connected with the other end of the voltage sampling subunit to form a first node, the first node is connected with the second control unit, and the other end of the voltage adjusting subunit is connected with the first control unit.

3. The high voltage generating circuit for a conduit of claim 2,

the voltage sampling sub-unit includes: one end of the sampling resistor is connected with the total output end;

the voltage adjustment subunit includes: the sampling resistor comprises a resistance adjustable chip, wherein the first end of the resistance adjustable chip is connected with the other end of the sampling resistor, the second end of the resistance adjustable chip is grounded, and the control end of the resistance adjustable chip is connected with the first control unit.

4. The high voltage generating circuit for a catheter according to claim 3, wherein the first control unit is specifically configured to send a feedback voltage adjustment instruction to the resistance-adjustable chip, so that the resistance-adjustable chip obtains a resistance adjustment amount according to the feedback voltage adjustment instruction, and adjusts the resistance of the resistance-adjustable chip according to the resistance adjustment amount.

5. The high voltage generating circuit for a catheter according to any one of claims 1-4, further comprising:

the input end of the voltage adjusting unit is connected with the output end of each voltage conversion unit, and the output end of the voltage adjusting unit is connected with the total output end and used for controlling the on-off between the output end of each voltage conversion unit and the total output end;

the second control unit is further configured to control the N voltage conversion units and the voltage adjustment unit according to the target voltage and the adjusted feedback voltage to adjust the output voltage of the total output terminal to obtain the target voltage.

6. The high voltage generating circuit for a catheter according to claim 5, wherein the N voltage transforming units cooperate with the N energy storage units to form N voltage intervals, the second control unit being specifically configured to: and acquiring a voltage interval corresponding to the target voltage, and controlling the N voltage conversion units and the voltage adjustment unit according to the voltage interval corresponding to the target voltage and the adjusted feedback voltage.

7. The high voltage generating circuit for a conduit of claim 5, further comprising:

the input end of the current adjusting unit is connected with the output end of the voltage adjusting unit, and the output end of the current adjusting unit is connected with the total output end and used for adjusting the output current of the total output end;

the second control unit is further configured to obtain a target power of the high-voltage generation circuit, and control the N voltage conversion units, the voltage adjustment unit, and the current adjustment unit according to the target power and the adjusted feedback voltage, so as to adjust the output voltage and the output current of the total output terminal to obtain the target power.

8. The high voltage generating circuit for a catheter according to claim 5, wherein the voltage adjusting unit comprises: the N first switches are in one-to-one correspondence with the N voltage conversion units, and each first switch is connected in series between the output end of the corresponding voltage conversion unit and the total output end.

9. The high voltage generating circuit for a catheter according to claim 7, wherein the current adjusting unit comprises M current adjusting branches connected in parallel, M being an integer greater than 1, and each current adjusting branch comprises:

one end of the current-limiting resistor is connected with the output end of the voltage adjusting unit;

and one end of the current limiting switch is connected with the other end of the current limiting resistor, and the other end of the current limiting switch is connected with the main output end.

10. The high voltage generating circuit for a conduit of claim 1, wherein each voltage conversion unit is a flyback conversion circuit, a forward conversion circuit, an LLC resonant circuit, a boost circuit, or a bridge circuit.

11. An ablation instrument comprising a catheter and the high voltage generation circuit for a catheter of any one of claims 1-10.

Technical Field

The invention relates to the technical field of pulsed electric field ablation, in particular to a high-voltage generating circuit for a catheter and an ablation tool.

Background

The ablation energy in the catheter ablation technology adopted for treating arrhythmia at present is mainly radio frequency energy and is assisted by freezing energy, and the two ablation modes have certain superiority in treating arrhythmia and have corresponding limitations, for example, the ablation energy has no selectivity for damaging tissues in an ablation area, and certain damage can be caused to adjacent esophagus, coronary artery, phrenic nerve and the like depending on the adhesion force of a catheter, so that the related technology of finding a quick, safe and efficient ablation energy to complete and achieve persistent pulmonary vein isolation without damaging adjacent tissues becomes a hotspot of research.

Pulsed electric field ablation is a new type of ablation using pulsed electric field as energy, and is gaining attention as a non-thermal ablation technique in clinical application. The pulsed electric field ablation technology is mainly characterized in that a high-voltage pulsed electric field with the pulse width of millisecond, microsecond or even nanosecond is generated, extremely high energy is released in a short time, and a cell membrane, even intracellular organelles such as endoplasmic reticulum, mitochondria, cell nucleus and the like can generate a large number of irreversible micropores, so that apoptosis of pathological cells is caused, and the expected treatment purpose is achieved. However, as a new energy ablation technology, the pulsed electric field ablation technology faces the defect that the output voltage of the high-voltage generating circuit cannot be rapidly switched, so that the clinical application of the pulsed electric field ablation technology is limited.

Disclosure of Invention

The present invention is directed to solving, at least to some extent, one of the technical problems in the related art. Therefore, a first object of the present invention is to provide a high voltage generating circuit for a catheter, which can realize fast switching of an output voltage to a target voltage through a plurality of voltage converting units and a voltage feedback unit, thereby improving the application prospect of the pulsed electric field ablation technology in arrhythmia treatment.

A second object of the invention is to propose an ablation instrument.

In order to achieve the above object, a first embodiment of the present invention provides a high voltage generating circuit for a catheter, including: the input ends of the N voltage conversion units are connected with the total input end of the high-voltage generating circuit after being connected in parallel, the output ends of the N voltage conversion units are connected with the total output end of the high-voltage generating circuit after being connected in series, the N energy storage units correspond to the N voltage conversion units one by one, each energy storage unit is connected between the output ends of the corresponding voltage conversion units, each voltage conversion unit in the N voltage conversion units is used for performing voltage conversion on the input voltage of the total input end and charging the corresponding energy storage unit, and N is an integer greater than 1; the detection end of the voltage feedback unit is connected with the total output end and is used for detecting the output voltage of the total output end to obtain a feedback voltage and adjusting the feedback voltage; the first control unit is connected with the adjusting end of the voltage feedback unit and is used for controlling the voltage feedback unit to adjust the feedback voltage; and the second control unit is connected with the output ends of the N voltage conversion units and the voltage feedback unit and is used for acquiring the target voltage of the high-voltage generating circuit and controlling the N voltage conversion units according to the target voltage and the adjusted feedback voltage so as to adjust the output voltage of the total output end to obtain the target voltage.

According to the high-voltage generating circuit for the catheter, the input end of the voltage conversion unit is connected with the total input end of the high-voltage generating circuit after being connected in parallel, the output end of the voltage conversion unit is connected with the total output end of the high-voltage generating circuit after being connected in series, the detection end of the voltage feedback unit is connected with the total output end and used for detecting the output voltage of the total output end to obtain the feedback voltage and the adjustment feedback voltage, the first control unit is connected with the adjustment end of the voltage feedback unit and used for controlling the voltage feedback unit to adjust the feedback voltage, the second control unit is used for obtaining the target voltage of the high-voltage generating circuit, and the N voltage conversion units are controlled according to the target voltage and the adjusted feedback voltage to adjust the output voltage of the total output end to obtain the target voltage. Therefore, the output voltage can be rapidly switched to the target voltage through the plurality of voltage conversion units and the voltage feedback unit, and the application prospect of the pulsed electric field ablation technology on arrhythmia treatment is improved.

According to an embodiment of the present invention, a voltage feedback unit includes: one end of the voltage sampling subunit is connected with the total output end; and one end of the voltage adjusting subunit is connected with the other end of the voltage sampling subunit to form a first node, the first node is connected with the second control unit, and the other end of the voltage adjusting subunit is connected with the first control unit.

According to one embodiment of the present invention, a voltage sampling subunit includes: one end of the sampling resistor is connected with the total output end; the voltage adjustment subunit includes: and the first end of the resistance adjustable chip is connected with the other end of the sampling resistor, the second end of the resistance adjustable chip is grounded, and the control end of the resistance adjustable chip is connected with the first control unit.

According to an embodiment of the present invention, the first control unit is specifically configured to send a feedback voltage adjustment instruction to the resistance adjustable chip, so that the resistance adjustable chip obtains a resistance adjustment amount according to the feedback voltage adjustment instruction, and adjusts the self resistance according to the resistance adjustment amount.

According to an embodiment of the present invention, the high voltage generating circuit for a catheter further comprises: the input end of the voltage adjusting unit is connected with the output end of each voltage conversion unit, and the output end of the voltage adjusting unit is connected with the total output end and used for controlling the on-off between the output end of each voltage conversion unit and the total output end; and the second control unit is also used for controlling the N voltage conversion units and the voltage regulation unit according to the target voltage and the regulated feedback voltage so as to regulate the output voltage of the total output end to obtain the target voltage.

According to an embodiment of the present invention, the N voltage conversion units cooperate with the N energy storage units to form N voltage intervals, and the second control unit is specifically configured to: and acquiring a voltage interval corresponding to the target voltage, and controlling the N voltage conversion units and the voltage adjustment unit according to the voltage interval corresponding to the target voltage and the adjusted feedback voltage.

According to an embodiment of the present invention, the high voltage generating circuit for a catheter further comprises: the input end of the current adjusting unit is connected with the output end of the voltage adjusting unit, and the output end of the current adjusting unit is connected with the total output end and used for adjusting the output current of the total output end; and the second control unit is also used for acquiring the target power of the high-voltage generating circuit and controlling the N voltage conversion units, the voltage adjusting unit and the current adjusting unit according to the target power and the adjusted feedback voltage so as to adjust the output voltage and the output current of the total output end to obtain the target power.

According to an embodiment of the present invention, a voltage adjusting unit includes: the N first switches correspond to the N voltage conversion units one by one, and each first switch is connected between the output end of the corresponding voltage conversion unit and the total output end in series.

According to an embodiment of the present invention, the current adjusting unit includes M current adjusting branches connected in parallel, and each current adjusting branch includes: one end of the current-limiting resistor is connected with the output end of the voltage adjusting unit; and one end of the current limiting switch is connected with the other end of the current limiting resistor, and the other end of the current limiting switch is connected with the main output end.

According to an embodiment of the present invention, each voltage conversion unit is a flyback conversion circuit, a forward conversion circuit, an LLC resonant circuit, a boost circuit, or a bridge circuit.

In order to achieve the above object, a second aspect of the present invention provides an ablation instrument, including a high voltage generation circuit for a catheter as in the first aspect.

According to the ablation tool provided by the embodiment of the invention, through the high-voltage generating circuit for the catheter, the output voltage can be rapidly switched to the target voltage through the plurality of voltage conversion units and the voltage feedback unit, and the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved.

Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.

Drawings

FIG. 1 is a schematic diagram of a high voltage generating circuit for a catheter according to a first embodiment of the present invention;

FIG. 2 is a schematic diagram of a high voltage generating circuit for a catheter according to a second embodiment of the present invention;

FIG. 3 is a schematic diagram of a high voltage generating circuit for a catheter according to a third embodiment of the present invention;

FIG. 4 is a schematic diagram of a high voltage generating circuit for a catheter according to a fourth embodiment of the present invention;

FIG. 5 is a schematic diagram of a first switch of a high voltage transmitting circuit for a catheter according to a fifth embodiment of the present invention;

fig. 6 is a schematic structural view of an ablation instrument in accordance with an embodiment of the invention.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are illustrative and intended to be illustrative of the invention and are not to be construed as limiting the invention.

The high voltage generating circuit for a catheter and an ablation instrument according to embodiments of the present invention will be described with reference to the accompanying drawings.

Fig. 1 is a schematic structural diagram of a high voltage generating circuit for a catheter according to a first embodiment of the present invention, and referring to fig. 1, the high voltage generating circuit may include: the circuit comprises N voltage conversion units (N is an integer larger than 1), N energy storage units, a voltage feedback unit 200, a first control unit 300 and a second control unit 400.

The input ends of the N voltage conversion units are connected in parallel and then connected with the total input end of the high-voltage generating circuit, the output ends of the N voltage conversion units are connected in series and then connected with the total output end of the high-voltage generating circuit, the N energy storage units correspond to the N voltage conversion units one to one, each energy storage unit is connected between the output ends of the corresponding voltage conversion units, and each voltage conversion unit in the N voltage conversion units is used for performing voltage conversion on the input voltage of the total input end and charging the corresponding energy storage unit; the detection end of the voltage feedback unit 200 is connected with the total output end and is used for detecting the output voltage of the total output end to obtain a feedback voltage and adjusting the feedback voltage; the first control unit 300 is connected to the adjustment end of the voltage feedback unit 200, and is configured to control the voltage feedback unit 200 to adjust the feedback voltage; the second control unit 400 is connected to the output terminals of the N voltage conversion units and the voltage feedback unit 200, and is configured to obtain a target voltage of the high voltage generation circuit, and control the N voltage conversion units according to the target voltage and the adjusted feedback voltage to adjust the output voltage of the total output terminal to obtain the target voltage.

Specifically, the voltage conversion unit and the energy storage unit may include a plurality of units, and the specific number may be selected according to actual use requirements. As a specific example, referring to fig. 1, the high voltage generation circuit may include four voltage transformation units (voltage transformation units 111, 121, 131, and 141, respectively) and four energy storage units (energy storage units 112, 122, 132, and 142, respectively). First input ends of the voltage conversion units 111, 121, 131 and 141 are connected and then connected with a total input positive terminal Vin of the high-voltage generation circuit; second input ends of the voltage conversion units 111, 121, 131 and 141 are connected and then connected with a total input negative end GND of the high voltage generation circuit; a first output end of the voltage conversion unit 111 is connected with one end of the corresponding energy storage unit 112, and a second output end of the voltage conversion unit 111 is connected with the other end of the corresponding energy storage unit 112; a first output end of the voltage conversion unit 121 is connected to one end of the corresponding energy storage unit 122 and the other end of the energy storage unit 112, and a second output end of the voltage conversion unit 121 is connected to the other end of the corresponding energy storage unit 122; a first output end of the voltage conversion unit 131 is connected to one end of the corresponding energy storage unit 132 and the other end of the energy storage unit 122, and a second output end of the voltage conversion unit 131 is connected to the other end of the corresponding energy storage unit 132; a first output terminal of the voltage conversion unit 141 is connected to one end of the corresponding energy storage unit 142, the input terminal of the current adjustment unit 600, and the other end of the energy storage unit 132, and a second output terminal of the voltage conversion unit 141 is connected to the other end of the corresponding energy storage unit 142 and the negative total output terminal GND of the high voltage generation circuit. When the high voltage generating circuit operates, the input terminals of the voltage converting units 111, 121, 131 and 141 are connected in parallel, and the same operating voltage can be obtained, but since the output terminals of the voltage converting units 111, 121, 131 and 141 are connected in series, the voltage at the output terminals of the voltage converting units 141, 131, 121 and 111 will increase step by step, that is, the voltage at one end of the energy storing units 142, 132, 122 and 112 increases step by step, that is, the voltage at D, C, B and the voltage at a point a in fig. 1 increase sequentially, for example, the voltage at a point D is the voltage of the energy storing unit 142, the voltage at a point C is the sum of the voltages of the energy storing units 142 and 132, and 122, the voltage at a point B is the sum of the voltages of the energy storing units 142, 132, 122 and 112.

The detection end of the voltage feedback unit 200 is connected with the total output positive end Vout for detecting the output voltage of the total output end to obtain the feedback voltage, the first control unit 300 is connected with the adjustment end of the voltage feedback unit 200, and the adjustment of the feedback voltage can be realized by controlling the voltage feedback unit 200, so that the speed of adjusting the output voltage to reach the target voltage can be further adjusted, and the stepless adjustment can be realized under the ideal condition. For example, when the output voltage needs to be rapidly adjusted to the target voltage, the first control unit 300 may control the voltage feedback unit 200 to adjust the feedback voltage, so that a larger difference exists between the output voltage corresponding to the adjusted feedback voltage and the target voltage, and the voltage closed-loop adjustment is performed based on the larger difference, so as to achieve rapid adjustment of the output voltage; on the contrary, the first control unit 300 may control the voltage feedback unit 200 to adjust the feedback voltage, so that the output voltage corresponding to the adjusted feedback voltage has a smaller difference with the target voltage, and the voltage closed-loop adjustment may be performed based on the smaller difference, so as to achieve the slow adjustment of the output voltage.

The second control unit 400 can control the plurality of voltage conversion units to realize fast switching of the output voltage of the total output end to the target voltage, for example, if the maximum voltage corresponding to each energy storage unit is 500V, the voltage adjustable range is 0-2000V, when the target voltage of 2000V needs to be obtained, four voltage conversion voltages can be controlled to simultaneously work to charge the corresponding energy storage units until the target voltage of 2000V is reached, and compared with the case of only adopting one voltage conversion unit, the speed of obtaining the output voltage is effectively improved. When the target voltage is switched from 2000V to 500V, the four energy storage units can be discharged simultaneously, and compared with the case that only one energy storage unit is adopted, the discharge time is shorter, so that the rapid switching of the output voltage can be realized. Meanwhile, a wide voltage range of 0-2000V can be achieved, only one voltage conversion unit is provided, the voltage range of 0-2000V cannot be achieved, or a transformer and a high-power transistor which need large volume can be achieved, and the voltage conversion device can achieve wide-range voltage output, and each voltage conversion unit can be achieved by small components due to the fact that output voltage is divided into N parts which are equivalent to low-voltage control.

Further, when the second control unit 400 controls the plurality of voltage conversion units according to the feedback voltage and the target voltage, the charging and discharging speeds of the voltage conversion unit that needs to operate, the energy storage unit that needs to be charged and discharged, and the energy storage unit that needs to be charged and discharged may be determined according to the difference between the feedback voltage and the target voltage, so as to realize the fast switching from the output voltage to the target voltage. For example, when the output voltage needs to be quickly adjusted to the target voltage, the first control unit 300 may control the voltage feedback unit 200 to adjust the feedback voltage, so that a larger difference exists between the output voltage corresponding to the adjusted feedback voltage and the target voltage, the second control unit 400 may determine the current voltage transformation unit that needs to operate or the energy storage unit that needs to be charged and discharged according to the target voltage, assuming that the current target voltage is 2000V, it is necessary that all four voltage transformation units operate to charge the corresponding energy storage unit, and meanwhile, the second control unit 400 controls the four voltage transformation units to charge the energy storage unit according to the larger difference, and adjusts the charging speed of the energy storage unit, thereby realizing quick adjustment of the output voltage to the target voltage. On the contrary, when the output voltage needs to be slowly adjusted to the target voltage of 2000V, the first control unit 300 may control the voltage feedback unit 200 to adjust the feedback voltage, so that the output voltage corresponding to the adjusted feedback voltage has a smaller difference with the target voltage, and the second control unit 400 may control the four voltage conversion units to charge the energy storage unit simultaneously or one by one according to the smaller difference, and adjust the charging speed of the energy storage unit, so as to realize the slow adjustment of the output voltage to the target voltage.

Therefore, the output voltage can be rapidly switched to the target voltage through the plurality of voltage conversion units and the voltage feedback unit, and the application prospect of the pulsed electric field ablation technology on arrhythmia treatment is improved.

In some embodiments, as shown in fig. 2, the voltage feedback unit 200 includes: a voltage sampling subunit 210 and a voltage adjusting subunit 220, wherein one end of the voltage sampling subunit 210 is connected to the total output positive terminal Vout; one end of the voltage adjusting subunit 220 is connected to the other end of the voltage sampling subunit 210 and forms a first node P, the first node P is connected to the second control unit 400, and the other end of the voltage adjusting subunit 220 is connected to the first control unit 300.

Optionally, as shown in fig. 3, the voltage sampling subunit 210 includes: one end of the sampling resistor R is connected with the total output positive end Vout; the voltage adjustment subunit 220 includes: and a first end of the resistance adjustable chip RIC is connected with the other end of the sampling resistor R, a second end of the resistance adjustable chip RIC is grounded, and a control end of the resistance adjustable chip RIC is connected with the first control unit 300. Further, the first control unit 300 is specifically configured to send a feedback voltage adjustment instruction to the resistance adjustable chip RIC, so that the resistance adjustable chip RIC obtains a resistance adjustment amount according to the feedback voltage adjustment instruction, and adjusts the self resistance according to the resistance adjustment amount.

Specifically, the sampling resistor R and the adjustable resistance chip RIC are connected in series to form a voltage sampling circuit to acquire the output voltage of the total output end to obtain a feedback voltage and send the feedback voltage to the second control unit 400, the first control unit 300 can generate a feedback voltage adjustment instruction according to an adjustment requirement and send the feedback voltage adjustment instruction to the adjustable resistance chip RIC, the adjustable resistance chip RIC changes the resistance value thereof according to the instruction to change the feedback voltage, and the second control unit 400 can rapidly adjust the output voltage of the total output positive terminal Vout to be the target voltage according to the target voltage and the adjusted feedback voltage.

For example, assuming that the output voltage of the total output positive terminal Vout is U1, the sampling resistor R is a fixed value Rx, the initial resistance of the resistance adjustable chip RIC is Rx, if the voltage of the total output positive terminal Vout needs to be reduced from U1 to U2, the feedback voltage is U1/2 without changing the resistance of the resistance adjustable chip RIC, the second control unit 400 can obtain the difference between the output voltage and the target voltage as U2-U1 according to the feedback voltage, and then perform voltage adjustment according to the voltage difference U2-U1. If the resistance value of the resistance adjustable chip RIC is adjusted to Rx/2, the feedback voltage is U1/3, the second control unit 400 obtains the difference between the output voltage and the target voltage according to the feedback voltage as U2-U1 × 2/3, and then performs voltage adjustment according to the voltage difference U2-U1 × 2/3. It can be understood that U2-U1 × 2/3 is increased compared to U2-U1, i.e., the voltage difference is increased, so that the adjustment according to the increased voltage difference can realize the fast adjustment of the output voltage. Therefore, the output voltage of the total output end can be quickly adjusted to be the target voltage by changing the resistance value of the resistance adjustable chip RIC.

On the contrary, if the output voltage of the total output terminal needs to be slowly adjusted to the target voltage, the resistance value of the resistance-adjustable chip RIC may be increased, for example, the resistance value of the resistance-adjustable chip RIC is adjusted to 2Rx, the feedback voltage is U1 × 2/3, the second control unit 400 may obtain the difference between the output voltage and the target voltage according to the feedback voltage as U2-U1 × 1/3, and at this time, perform voltage adjustment according to the voltage difference U2-U1 × 4/3. It can be understood that U2-U1 × 4/3 is reduced compared to U2-U1, i.e., the voltage difference becomes smaller, so that the adjustment according to the reduced voltage difference can realize the fast adjustment of the output voltage.

In some embodiments, as shown in fig. 4, the high voltage generating circuit for a catheter further includes a voltage adjusting unit 500, an input terminal of the voltage adjusting unit 500 is connected to an output terminal of each voltage converting unit, and an output terminal of the voltage adjusting unit 500 is connected to the total output positive terminal Vout, so as to control on/off between the output terminal of each voltage converting unit and the total output positive terminal Vout; the second control unit 400 is further configured to control the N voltage conversion units and the voltage adjustment unit 500 according to the target voltage and the adjusted feedback voltage to adjust the output voltage of the total output positive terminal Vout to obtain the target voltage.

Specifically, a first input terminal of the voltage adjusting unit 500 is connected to the first output terminal of the voltage converting unit 111 and one terminal of the corresponding energy storing unit 112, a second input terminal of the voltage adjusting unit 500 is connected to the first output terminal of the voltage converting unit 121, the other terminal of the energy storing unit 112 and one terminal of the energy storing unit 122, a third input terminal of the voltage adjusting unit 500 is connected to the first output terminal of the voltage converting unit 131, the other terminal of the energy storing unit 122 and one terminal of the energy storing unit 132, and a fourth input terminal of the voltage adjusting unit 500 is connected to the first output terminal of the voltage converting unit 141, the other terminal of the energy storing unit 132 and one terminal of the energy storing unit 142.

The second control unit 400 obtains the target voltage of the high voltage generating circuit and the adjusted feedback voltage, and controls the voltage converting units 111, 121, 131, 141 and the voltage adjusting unit 500 according to the target voltage and the adjusted feedback voltage, so as to quickly adjust the output voltage of the total output terminal to the target voltage. For example, when the output voltage needs to be quickly adjusted to the target voltage, the first control unit 300 may control the voltage feedback unit 200 to adjust the feedback voltage, so that a larger difference exists between the output voltage corresponding to the adjusted feedback voltage and the target voltage, the second control unit 400 may determine, according to the target voltage, a voltage conversion unit that needs to be operated currently or an energy storage unit that needs to be charged and discharged, and a voltage conversion unit that needs to be communicated with the total output positive terminal Vout, and if the current target voltage is 2000V, the voltage conversion unit 111 needs to be communicated with the total output terminal Vout, and at the same time, the four voltage conversion units are controlled to charge the energy storage unit according to the larger difference, and the charging speed of the energy storage unit is adjusted, thereby realizing quick adjustment of the output voltage to the target voltage. On the contrary, when the output voltage needs to be slowly adjusted to the target voltage of 2000V, the first control unit 300 may control the voltage feedback unit 200 to adjust the feedback voltage, so that the output voltage corresponding to the adjusted feedback voltage has a smaller difference with the target voltage, and the second control unit 400 may control the four voltage conversion units to charge the energy storage unit simultaneously or one by one according to the smaller difference, and adjust the charging speed of the energy storage unit, so as to realize the slow adjustment of the output voltage to the target voltage.

For another example, when the output voltage needs to be rapidly adjusted to the target voltage 300V, the first control unit 300 may control the voltage feedback unit 200 to adjust the feedback voltage, so that a larger difference exists between the output voltage corresponding to the adjusted feedback voltage and the target voltage, the second control unit 400 determines that the required voltage conversion unit 141 is communicated with the total output terminal Vout according to the target voltage, and controls the voltage conversion unit to charge the energy storage unit according to the larger difference, and adjusts the charging speed of the energy storage unit, thereby achieving rapid adjustment of the output voltage to the target voltage. On the contrary, when the output voltage needs to be slowly adjusted to the target voltage 300V, the first control unit 300 may control the voltage feedback unit 200 to adjust the feedback voltage, so that the output voltage corresponding to the adjusted feedback voltage has a smaller difference with the target voltage, and the second control unit 400 may control the voltage conversion unit to charge the energy storage unit according to the smaller difference, and adjust the charging speed of the energy storage unit, so as to realize the slow adjustment of the output voltage to the target voltage.

Therefore, the output voltage can be rapidly switched to the target voltage through the plurality of voltage conversion units, the voltage feedback unit and the voltage adjusting unit, and the application prospect of the pulsed electric field ablation technology on arrhythmia treatment is improved.

Further, N voltage conversion units cooperate with N energy storage units to form N voltage intervals, and the second control unit 400 is specifically configured to: and acquiring a voltage interval corresponding to the target voltage, and controlling the N voltage conversion units and the voltage adjustment unit 500 according to the voltage interval corresponding to the target voltage and the adjusted feedback voltage.

Specifically, as shown in fig. 4, the four voltage transformation units and the four energy storage units cooperate to form four voltage intervals, and assuming that the highest voltages of the points A, B, C and D are 2000V, 1500V, 1000V and 500V, the four voltage intervals are [0V,500V ], [500V,1000V ], [1000V,1500V ] and [1500V,2000V ].

When the output voltage needs to be rapidly adjusted to the target voltage, the first control unit 300 can control the voltage feedback unit 200 to adjust the feedback voltage, so that the output voltage corresponding to the adjusted feedback voltage has a larger difference value with the target voltage, the second control unit 400 can determine a corresponding voltage interval according to the target voltage, and further determine a voltage conversion unit which needs to work currently or an energy storage unit which needs to be charged and discharged, and a voltage conversion unit which needs to be communicated with the total output positive terminal Vout according to the voltage interval. Assuming that the current target voltage is 2000V and the corresponding voltage interval is [1500V,2000V ], the voltage conversion unit 111 needs to be communicated with the total output terminal Vout, and meanwhile, the four voltage conversion units are controlled to charge the energy storage unit according to a larger difference value, and the charging speed of the energy storage unit is adjusted, so as to realize the rapid adjustment of the output voltage to the target voltage. On the contrary, when the output voltage needs to be slowly adjusted to the target voltage of 2000V, the first control unit 300 may control the voltage feedback unit 200 to adjust the feedback voltage, so that the output voltage corresponding to the adjusted feedback voltage has a smaller difference with the target voltage, and the second control unit 400 may control the four voltage conversion units to charge the energy storage unit simultaneously or one by one according to the smaller difference, and adjust the charging speed of the energy storage unit, so as to realize the slow adjustment of the output voltage to the target voltage. Therefore, the rapid adjustment of the output voltage to the target voltage can be realized.

In some embodiments, as shown in fig. 4, the high voltage generation circuit for a catheter further comprises: the input end of the current adjusting unit 600 is connected with the output end of the voltage adjusting unit 500, and the output end of the current adjusting unit 600 is connected with the total output positive terminal Vout and used for adjusting the output current of the total output positive terminal Vout; the second control unit 400 is further configured to obtain a target power of the high-voltage generating circuit, and control the N voltage converting units, the voltage adjusting unit 500, and the current adjusting unit 600 according to the target power and the adjusted feedback voltage, so as to adjust the output voltage and the output current of the total output positive terminal Vout to obtain the target power.

Specifically, the second control unit 400 may control the current adjustment unit 600 to change the output current of the total output terminal by changing the size of the resistor built in the current adjustment unit 600, for example, the current adjustment unit 600 may be a variable resistor with steplessly adjustable resistance, and the output current may be directly adjusted to the required current by changing the resistance value of the variable resistor, so as to realize fast switching of different output currents. Further, the second control unit 400 may implement flexible adjustment of the output voltage, the output current, and the output power by controlling the N voltage converting units, the voltage adjusting unit 500, and the current adjusting unit 600. Specifically, when only the target power is required, the output voltage and/or the output current of the total output terminal can be adjusted in the manner described above, so that the output power reaches the target power; when both the target power and the target voltage are required, the output voltage of the total output terminal can be adjusted in the above manner to reach the target voltage, and then the output current is changed by adjusting the internal resistance of the current adjusting unit 600, so that the output power reaches the target power.

It should be noted that the second control unit 400 may also control the N voltage converting units, the voltage adjusting unit 500, and the current adjusting unit 600 to achieve fast switching of the target power. For example, when only the target power is required, assuming that the target power is 1000w and the target voltage before switching is 800V, if the output current can reach 1.25A, the target power can be quickly adjusted by adjusting the output current, and compared with the scheme that only one voltage conversion unit and corresponding energy storage unit are provided, the process of adjusting the output voltage is omitted, and the adjustment of the output voltage involves a charging and discharging process, so that the adjustment speed of the target power with the current adjustment unit 600 is faster and more energy-saving. In the case that both the target power and the target voltage are required, the embodiment can realize the output of any target voltage and any target power within the range, and the output of any target voltage and any target power may not have a constraint relationship between the target power and the target power, for example, only one voltage conversion unit and a corresponding energy storage unit are provided, and the target power and the target voltage are in a corresponding relationship, so that flexible adjustment cannot be realized.

Therefore, the fast and flexible switching among different output voltages, output currents and output powers can be realized through the plurality of voltage conversion units, the voltage feedback unit, the voltage adjusting unit and the current adjusting unit.

In some embodiments, as shown in fig. 5, the voltage adjusting unit 500 includes: the N first switches correspond to the N voltage conversion units one by one, and each first switch is connected between the output end of the corresponding voltage conversion unit and the total output positive end Vout in series.

Specifically, the voltage adjusting unit 500 includes four first switches, i.e., first switches S1, S2, S3 and S4, respectively, and the first switches S1, S2, S3 and S4 are respectively connected in series between the output terminal of the corresponding voltage converting unit and the positive total output terminal Vout. The voltage output of the corresponding voltage conversion unit is realized by controlling the on and off of the first switches S1, S2, S3 and S4, and then the fast switching of the output voltage is realized, for example, the first switch S4 is closed, the rest of the first switches are open, the output voltage is VO, and if the first switch S1 is closed and the rest of the first switches are open, the output voltage is 4VO, so that the fast switching of the output voltage from VO to 4VO is realized, and the output voltage range is expanded.

In some embodiments, as shown in fig. 5, the current adjusting unit 600 includes M current adjusting branches connected in parallel, M is an integer greater than 1, and each current adjusting branch includes: a current limiting resistor (e.g., R11), one end of the current limiting resistor (e.g., R11) being connected to the output terminal of the voltage adjusting unit 500; and a current limiting switch (such as S11), wherein one end of the current limiting switch (such as S11) is connected with the other end of the current limiting resistor (such as R11), and the other end of the current limiting switch (such as S11) is connected with the positive end Vout of the total output.

Specifically, four current regulation branches are taken as an example for explanation, the first current regulation branch includes a current limiting resistor R11 and a current limiting switch S11, one end of the current limiting resistor R11 is connected to the output terminal of the voltage regulation unit 500, one end of the current limiting switch S11 is connected to the other end of the current limiting resistor R11, and the other end of the current limiting switch S11 is connected to the total output positive terminal Vout; the second current adjusting branch comprises a current-limiting resistor R22 and a current-limiting switch S22, one end of the current-limiting resistor R22 is connected with the output end of the voltage adjusting unit 500, one end of the current-limiting switch S22 is connected with the other end of the current-limiting resistor R22, and the other end of the current-limiting switch S22 is connected with the positive end Vout of the total output; the third current adjusting branch comprises a current-limiting resistor R33 and a current-limiting switch S33, one end of the current-limiting resistor R33 is connected with the output end of the voltage adjusting unit 500, one end of the current-limiting switch S33 is connected with the other end of the current-limiting resistor R33, and the other end of the current-limiting switch S33 is connected with the positive end Vout of the total output; the fourth current adjusting branch comprises a current limiting resistor R44 and a current limiting switch S44, one end of the current limiting resistor R44 is connected to the output terminal of the voltage adjusting unit 500, one end of the current limiting switch S44 is connected to the other end of the current limiting resistor R44, and the other end of the current limiting switch S44 is connected to the positive output terminal Vout. It should be noted that the resistances of the current limiting resistors R11, R22, R33, and R44 may be the same or different.

When the high-voltage generating circuit works, as shown in fig. 5, the first to fourth current adjusting branches are connected in parallel, the voltage obtained by each current adjusting branch is HV _ OUT, and the on-off states of different current adjusting branches are controlled by controlling the on-off of the current limiting switches in the current adjusting branches, so as to adjust the output current of the total output positive terminal Vout according to the current limiting resistors of the turned-on current adjusting branches. For example, when the voltage HV _ OUT input to the current adjusting unit 600 is unchanged, the current limiting switch S11 is closed, the remaining current limiting switches are opened, the output current is the ratio of the input voltage HV _ OUT to the current limiting resistor R11, the current limiting switches S11 and S22 are closed, the remaining current limiting switches are opened, and the output current is the ratio of the input voltage HV _ OUT to the current limiting resistors R11 and R22 connected in parallel, so that the output current can be switched quickly, that is, the current limiting resistors with different resistance values are selected, or the current limiting resistors with different numbers are selected to adjust the output current of the total output positive terminal Vout.

In some embodiments, each voltage conversion unit is a flyback conversion circuit, a forward conversion circuit, an LLC resonant circuit, a boost circuit, or a bridge circuit. That is to say, the voltage conversion unit in this application can be flyback conversion circuit, forward conversion circuit, LLC resonant circuit, exempt from circuit or bridge circuit etc. and guarantee that the type of voltage conversion unit is unanimous in the use, specifically adopt which kind of mode can select to set up according to actual demand.

In summary, according to the high voltage generating circuit for a catheter of the embodiment of the present invention, the input terminals of the voltage converting units are connected in parallel and then connected to the total input terminal of the high voltage generating circuit, the output terminals of the voltage converting units are connected in series and then connected to the total output terminal of the high voltage generating circuit, the detection terminals of the voltage feedback units are connected to the total output terminal for detecting the output voltage of the total output terminal to obtain the feedback voltage and adjust the feedback voltage, the first control unit is connected to the adjustment terminal of the voltage feedback unit for controlling the voltage feedback units to adjust the feedback voltage, the second control unit is used for obtaining the target voltage of the high voltage generating circuit, and the N voltage converting units are controlled according to the target voltage and the adjusted feedback voltage to adjust the output voltage of the total output terminal to obtain the target voltage. Therefore, the output voltage can be rapidly switched to the target voltage through the plurality of voltage conversion units and the voltage feedback unit, and the application prospect of the pulsed electric field ablation technology on arrhythmia treatment is improved.

Fig. 6 is a schematic structural diagram of an ablation instrument according to an embodiment of the present invention, and referring to fig. 6, the ablation instrument 1000 includes the high voltage generation circuit 100 for a catheter described above.

According to the ablation tool provided by the embodiment of the invention, through the high-voltage generating circuit for the catheter, the output voltage can be rapidly switched to the target voltage through the plurality of voltage conversion units and the voltage feedback unit, and the application prospect of the pulsed electric field ablation technology in arrhythmia treatment is improved.

It should be noted that the logic and/or steps represented in the flowcharts or otherwise described herein, such as an ordered listing of executable instructions that can be considered to implement logical functions, can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device, such as a computer-based system, processor-containing system, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions. For the purposes of this description, a "computer-readable medium" can be any means that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of the computer-readable medium would include the following: an electrical connection (electronic device) having one or more wires, a portable computer diskette (magnetic device), a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium could even be paper or another suitable medium upon which the program is printed, as the program can be electronically captured, via for instance optical scanning of the paper or other medium, then compiled, interpreted or otherwise processed in a suitable manner if necessary, and then stored in a computer memory.

It should be understood that portions of the present invention may be implemented in hardware, software, firmware, or a combination thereof. In the above embodiments, the various steps or methods may be implemented in software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, any one or combination of the following techniques, which are known in the art, may be used: a discrete logic circuit having a logic gate circuit for implementing a logic function on a data signal, an application specific integrated circuit having an appropriate combinational logic gate circuit, a Programmable Gate Array (PGA), a Field Programmable Gate Array (FPGA), or the like.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.