阅读说明：本技术 应用于微流控芯片的液体混匀装置以及微流控芯片 (Liquid mixing device applied to micro-fluidic chip and micro-fluidic chip ) 是由 梁品洪 陈亚洪 周昭瑞 汪凯 刘成 于 2021-06-04 设计创作，主要内容包括：本发明公开了应用于微流控的液体混匀装置,包括：本体,所述本体中设置有液体流动系统,所述液体流动系统包括用于装载待混匀液体的溶液腔和与所述溶液腔连通的缓冲腔；和动力机构,用于周期性地为所述液体流动系统产生正向和负向的气压,形成推动待混匀液体流动的动力,使待混匀液体在所述溶液腔和所述缓冲腔之间往复流动。本发明还公开了一种微流控芯片,包括本发明公开的应用于微流控的液体混匀装置。本发明至少解决了传统的混匀工具占用空间大、操作复杂以及容易发生泄漏的技术问题。(The invention discloses a liquid mixing device applied to microfluidics, which comprises: the liquid mixing device comprises a body, wherein a liquid flowing system is arranged in the body and comprises a solution cavity for loading liquid to be mixed uniformly and a buffer cavity communicated with the solution cavity; and the power mechanism is used for periodically generating positive and negative air pressure for the liquid flowing system to form power for pushing the liquid to be uniformly mixed to flow so that the liquid to be uniformly mixed flows between the solution cavity and the buffer cavity in a reciprocating manner. The invention also discloses a micro-fluidic chip which comprises the liquid mixing device applied to micro-fluidic disclosed by the invention. The invention at least solves the technical problems of large occupied space, complex operation and easy leakage of the traditional blending tool.)

1. Be applied to micro-fluidic liquid mixing device, its characterized in that includes:

the liquid mixing device comprises a body, wherein a liquid flowing system is arranged in the body and comprises a solution cavity for loading liquid to be mixed uniformly and a buffer cavity communicated with the solution cavity; and

and the power mechanism is used for periodically generating positive and negative air pressure for the liquid flowing system to form power for pushing the liquid to be uniformly mixed to flow so that the liquid to be uniformly mixed flows between the solution cavity and the buffer cavity in a reciprocating manner.

2. The microfluidic liquid blending device according to claim 1, wherein the liquid flow system is hermetically sealed.

3. The microfluidic liquid blending device according to claim 2, wherein the liquid flow system further comprises:

the cavity channel is communicated with the solution cavity and the buffer cavity;

a carrier component slidably connected in the channel;

a first fluid chamber in communication with the channel;

a second fluid chamber in communication with the channel;

wherein the carrier component has a channel disposed therein;

when the carrier component slides to a first preset position in the cavity channel, the channel communicates the solution cavity with the buffer cavity;

the channel communicates the first fluid chamber with the solution chamber when the carrier component slides in the channel to a second predetermined position,

the channel communicates with the second liquid chamber when the carrier component slides in the channel to a third predetermined position.

4. The microfluidic liquid blending device according to claim 1, wherein the liquid flow system further comprises: an air cavity communicated with the solution cavity;

the power mechanism comprises: a sliding member slidably connected in the air chamber;

wherein the power mechanism is caused to periodically generate positive and negative air pressures as the sliding member reciprocates in the air chamber.

5. The microfluidic liquid mixing device as claimed in claim 4, wherein the outer peripheral wall of the sliding member abuts against the inner side wall of the air chamber on the sliding path.

6. The liquid blending device applied to microfluidics according to claim 4, wherein a flexible sealing member is arranged on the outer peripheral wall of the sliding member on the sliding path, and the flexible sealing member is abutted against the inner side wall of the air cavity.

7. The liquid blending device applied to microfluidics according to claim 4, wherein the power mechanism further comprises:

and the cam component is connected with the sliding component, and when the cam component rotates, the cam component drives the sliding component to do reciprocating motion.

8. The liquid blending device applied to microfluidics according to any one of claims 1 to 7, wherein the body comprises a substrate and a sealing cover;

wherein the liquid flowing system is arranged in the substrate, and the cover covers the substrate and is used for sealing the liquid flowing system.

9. The microfluidic liquid blending device according to claim 7, wherein the body comprises a substrate and a cover; wherein the liquid flow system is arranged in the substrate, and the cover covers the substrate and is used for sealing and arranging the liquid flow system;

the cam member is located outside the base plate, and the cam member is connected with the sliding member through a connecting member.

10. The microfluidic chip is characterized by comprising the liquid mixing device applied to the microfluidic chip in any one of claims 1 to 9.

Technical Field

The invention relates to the technical field of liquid mixing. More specifically, the invention relates to a liquid mixing device applied to microfluidics and a microfluidic chip.

Background

In vitro diagnostic tests, it is necessary to mix a plurality of fluids to accomplish the testing task. The traditional blending method mainly comprises the following steps: 1) adding the liquid sample and the diluent into a beaker, and stirring and uniformly mixing by using a glass rod; 2) inverting back and forth with two beakers to mix the liquid; 3) mix by shaking back and forth with a single beaker. The above blending methods have the following irreparable defects: 1) The blending tool (such as the beaker and the glass rod) occupies a large space; 2) too many blending tools and complex operation process; 3) easily generates leakage phenomenon and causes pollution to the environment.

Disclosure of Invention

It is an object of the present invention to at least solve the above problems and to provide corresponding advantages.

The invention also aims to provide at least one liquid blending device applied to the microfluidic chip, which is provided with a power mechanism, wherein the power mechanism is used for pushing liquid to be blended to reciprocate in the liquid blending device applied to the microfluidic chip so as to achieve the aim of blending the liquid, so that the problems of large occupied space, complex operation and easy leakage of the traditional blending tool can be solved. It should be understood that the "liquid to be mixed" according to the present invention refers to a mixed solution including at least two liquids, for example, a sample liquid and a diluent; the two liquids may be different in concentration or different in composition. On the basis of the above, the invention also provides a corresponding microfluidic chip. Specifically, the invention is realized by the following technical scheme:

< first aspect of the invention >

The first aspect provides a liquid mixing device applied to microfluidics, which comprises:

the liquid mixing device comprises a body, wherein a liquid flowing system is arranged in the body and comprises a solution cavity for loading liquid to be mixed uniformly and a buffer cavity communicated with the solution cavity; and

and the power mechanism is used for periodically generating positive and negative air pressure for the liquid flowing system to form power for pushing the liquid to be uniformly mixed to flow so that the liquid to be uniformly mixed flows between the solution cavity and the buffer cavity in a reciprocating manner. According to the liquid blending device applied to the micro-fluidic system, the liquid flowing system is arranged inside the body and can be integrated with the power mechanism into a whole structure, and as long as liquid to be blended is added into the solution cavity, the liquid to be blended can flow back and forth between the solution cavity and the buffer cavity through the power mechanism, so that the blending effect is achieved.

Therefore, compared with the prior art, the liquid blending device applied to microfluidics provided by the invention can reduce the number of blending tools.

Moreover, with body and power unit integrated structure as an organic whole, can make apparent improvement in the degree that the volume reduces, consequently, can effectually reduce the volume of blending instrument to solve the big technical problem of traditional blending instrument occupation space.

In addition, the liquid mixing device applied to the micro-fluidic system provided by the invention can ensure that the liquid to be mixed can flow back and forth between the solution cavity and the buffer cavity only by periodically pushing the liquid to be mixed to flow through the power mechanism. In the blending process, various blending tools are not required, and the operation flow is simple; the technical problem that the operation of the traditional blending tool is complex is solved, so that the operation process of blending the liquid can be effectively simplified.

In some embodiments, the liquid flow system is hermetically sealed.

Through the technical scheme, the liquid mixing operation can be completed in a closed space, and the phenomenon of liquid leakage in the liquid mixing process is avoided.

In some technical schemes, the liquid flowing system is hermetically arranged inside the liquid mixing device applied to the microfluidic chip.

In some embodiments, the fluid flow system is in communication with the motive mechanism via an airway.

In some aspects, the liquid flow system further comprises: an air cavity communicated with the solution cavity;

the power mechanism comprises: a sliding member slidably connected in the air chamber;

wherein the power mechanism is caused to periodically generate positive and negative air pressures as the sliding member reciprocates in the air chamber.

Through the technical scheme, power can be provided for the flowing of the liquid so as to realize the reciprocating motion of the liquid.

In some embodiments, the outer peripheral wall of the slide member abuts against an inner side wall of the air chamber in the slide path.

In some technical solutions, a flexible sealing member is disposed on the outer circumferential wall of the sliding member, and the flexible sealing member is made of silicone, rubber, or the like.

Through the technical scheme, the closed air obtaining cavity can be formed, so that the sliding component can periodically slide in the air cavity to generate positive or negative air obtaining pressure.

In some embodiments, the sliding member is a glue stick.

In some embodiments, the power mechanism further comprises:

and the cam component is connected with the sliding component, and when the cam component rotates, the cam component drives the sliding component to do reciprocating motion.

Through the technical scheme, the power of movement can be provided for the liquid to be uniformly mixed.

In some embodiments, the power mechanism further comprises:

and a connecting member having one end connected to the sliding member and the other end connected to the cam member.

In some aspects, the liquid flow system further comprises:

the cavity channel is communicated with the solution cavity and the buffer cavity;

a carrier component slidably connected in the channel;

a first fluid chamber in communication with the channel;

a second fluid chamber in communication with the channel;

wherein the carrier component has a channel disposed therein;

when the carrier component slides to a first preset position in the cavity channel, the channel communicates the solution cavity with the buffer cavity;

the channel communicates the first fluid chamber with the solution chamber when the carrier component slides in the channel to a second predetermined position,

the channel communicates with the second liquid chamber when the carrier component slides in the channel to a third predetermined position.

Further, the buffer cavity is communicated with the cavity channel through a first flow channel, and the solution cavity is communicated with the cavity channel through a second flow channel, wherein when the carrier liquid component slides to a first preset position in the cavity channel, the first flow channel is communicated with the second flow channel through the channel, and a first flow path is formed.

Further, the solution chamber is communicated with the channel through a third flow channel, and the first liquid chamber is communicated with the channel through a fourth flow channel, wherein when the carrier liquid component slides to a second preset position in the channel, the channel is communicated with the third flow channel and the fourth flow channel to form a second flow path.

Further, the second liquid cavity is communicated with the cavity channel through a fifth flow channel.

In some technical schemes, the liquid mixing device further comprises:

a base for housing the fluid flow system and the power mechanism; and the number of the first and second groups,

and the sealing cover covers the base body and is used for sealing and arranging the liquid blending device.

< second aspect of the invention >

The second aspect provides a microfluidic chip, which comprises the liquid mixing device applied to the microfluidic chip in the first aspect.

The technical effects of the embodiment of the invention at least comprise:

according to the liquid blending device applied to the microfluidic chip, the liquid to be blended is pushed to reciprocate in the liquid blending device applied to the microfluidic chip through the power mechanism, so that the technical problems that the traditional blending tool occupies a large space, is complex to operate and is easy to leak are solved. Therefore, the beneficial effects of the invention at least comprise: 1) the volume of the blending tool is effectively reduced; 2) the operation process of uniformly mixing the liquid is effectively simplified; 3) the liquid mixing operation can be completed in a closed space, and the phenomenon of liquid leakage in the liquid mixing process is avoided; 4) the power can be provided for the flowing of the liquid so as to realize the reciprocating motion of the liquid; 5) a closed air obtaining cavity can be formed, so that the sliding component can periodically slide in the air cavity to generate positive or negative air obtaining pressure; 6) can provide the power of movement for the liquid to be mixed.

Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the description of the embodiments of the present application will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained according to these drawings without inventive exercise.

FIG. 1 is a schematic structural view of a base and a closure of the present invention in some embodiments;

FIG. 2 is a schematic diagram of a fluid blending apparatus of the present invention in some embodiments;

FIG. 3 is a schematic diagram of a fluid blending apparatus according to another embodiment of the present invention;

FIG. 4 is a schematic view of the fluid blending apparatus of the present invention in some embodiments moved to a third predetermined position;

FIG. 5 is a schematic view of the fluid blending apparatus of the present invention in some embodiments moved to a second predetermined position;

FIG. 6 is a schematic view of the fluid blending apparatus of the present invention in some embodiments moved to a first predetermined position;

FIG. 7 is a schematic diagram of a fluid blending device according to still another embodiment of the present invention;

description of reference numerals:

1. a liquid blending device; 10. a body; 110. a liquid flow system; 111. a solution chamber; 112. a buffer chamber; 113. an air cavity; 114. a carrier liquid component; 1141. a channel; 115. a lumen; 116. a first fluid chamber; 117. a second fluid chamber; 120. a substrate; 130. sealing the cover; 30. an airway; 40. a first flow passage; 50. a second flow passage; 60. a third flow path 70, a fourth flow path; 80. A fifth flow channel; 20. a power mechanism; 210. a sliding member; 220. a cam member; 221. a wheel; 222. a protruding portion of the wheel; 230. a connecting member; 231. a connecting surface; p1, first predetermined position; p2, second predetermined position; p3, third predetermined position.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more clearly and completely apparent, the technical solutions in the embodiments of the present application will be described below in conjunction with the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

The terms "first", "second", and "third" and the like in the description of the embodiments of the present application are used for distinguishing different objects, and are not used for describing a particular order of the objects. For example, the first and second fluid chambers are used to distinguish between different fluid chambers, rather than to describe a particular order of fluid chambers; as another example, the first flow channel, the second flow channel, the third flow channel, the fourth flow channel, and the fifth flow channel are used to distinguish different flow channels, and are not used to describe a specific order of flow channels. Further, the orientations and positional relationships indicated by the terms "upper", "lower", "top", "bottom", "inner", "outer", and the like are based on the orientations and positional relationships shown in the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or apparatus referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the embodiments of the present application, words such as "exemplary" or "for example" are used to mean serving as an example, instance, or illustration. Any embodiment or design described herein as "exemplary" or "e.g.," is not necessarily to be construed as preferred or advantageous over other embodiments or designs. Rather, use of the word "exemplary" or "such as" is intended to present concepts related in a concrete fashion.

It should be noted that, in this document, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements explicitly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

< liquid mixing device for microfluidics >

In a first aspect of the present invention, a liquid blending device 1 applied to microfluidics is provided, as shown in fig. 1 and fig. 2, the liquid blending device 1 includes a body 10 and a power mechanism 20. Wherein a liquid flow system 110 is provided in the body 10. The fluid flowing system 110 is connected to the actuating mechanism 20 by power, and in fig. 2, is mainly connected by pneumatic power.

The power mechanism 20 can periodically generate positive and negative air pressures for the liquid flowing system 110, and periodically form positive and negative air pressure powers, so as to push the liquid to be mixed to flow back and forth in the liquid flowing system 110, thereby mixing the liquid to be mixed.

The body 10 is a physical/mechanical structure in the field of microfluidics, and is mainly used to construct the fluid flow system 110 and to establish a power connection with the power mechanism 20. Thus, the shape of the body 10 is not required in this application, as long as a liquid flow system can be constructed (e.g., machined, etched) therein. In addition, in terms of manufacturing materials, the body 10 may be made of materials used in the microfluidic field for manufacturing conventional devices, such as microfluidic chips or devices; the material used for preparing the body 10 may be any of those used for preparing the aforementioned conventional devices, such as a silicon material (further, may be crystalline silicon), glass, or a high molecular polymer material. Wherein, the high molecular polymer material can be selected from one or more than two of thermoplastic polymer, solidified polymer and solvent volatile polymer; the thermoplastic polymer may be Polyamide (PI), Polymethylmethacrylate (PMMA), Polycarbonate (PC), polyethylene terephthalate (PET), etc., the curable polymer may be Polydimethylsiloxane (PDMS), epoxy resin, polyurethane, etc., and the solvent-volatile polymer may be acrylic, rubber, fluoroplastic, etc.

The liquid flowing system 110 includes a solution chamber 111 and a buffer chamber 112, and the solution chamber 111 and the buffer chamber 112 may be rectangular, but may be tapered, spherical or other shapes in other embodiments.

In addition, in some embodiments, the volume of the solution chamber 111 may be larger than the volume of the buffer chamber 112. The design aims to save structural materials under the condition of not influencing the liquid mixing effect, thereby reducing the liquid mixing cost. The specific principle is as follows: the liquid to be mixed is influenced by the forward air pressure, flows out of the solution cavity 111 and flows into the buffer cavity 112, however, when the power formed by the forward air pressure is not enough to push all the liquid in the whole solution cavity 111 to completely flow out of the solution cavity 111, or when the power formed by the forward air pressure is not enough to push all the liquid flowing out of the solution cavity 111 to completely flow into the buffer cavity 112, the whole capacity of the buffer cavity 112 at this time may be smaller than the capacity of the solution cavity 111, and accordingly, the whole structure of the buffer cavity 112 may be smaller than the structure of the solution cavity 111, so as to save structural materials and reduce the liquid mixing cost. (ii) a Of course, in other embodiments, the volume of the solution chamber 111 and the buffer chamber 112 may be configured otherwise, and is not limited to the above-mentioned volume relationship.

In addition, the solution cavity 111 is communicated with the buffer cavity 112 through a first circulation path, and when the power mechanism 20 periodically generates positive and negative air pressures, the liquid to be mixed periodically flows out of the solution cavity 111, flows into the buffer cavity 112 through the first circulation path, flows out of the buffer cavity 112, and flows into the solution cavity 111 through the first circulation path. The liquid to be mixed flows back and forth in the solution cavity 111 and the buffer cavity 112 periodically, so that the liquid to be mixed can be mixed quickly.

It should be noted that, herein, the "positive direction" and the "negative direction" represent the flowing direction of the air pressure, so as to visually describe the transmission direction of the air pressure power formed by the air pressure, and therefore, cannot be considered as a limitation to the present application. For example, if the transmission direction of the pneumatic power formed according to the positive air pressure may be from the air chamber 113 toward the solution chamber 111; then, the transmission direction of the pneumatic power according to the negative air pressure may be from the solution chamber 111 toward the air chamber 113.

As described above, it can be understood that the liquid blending device applied to microfluidics provided by the present invention arranges the liquid flow system 110 inside the body 10, and can be integrated with the power mechanism into an integrated structure, and as long as the liquid to be blended is added into the solution chamber 111, the liquid to be blended can be made to flow back and forth between the solution chamber 111 and the buffer chamber 112 through the power mechanism, so as to achieve the effect of blending.

Therefore, compared with the prior art, the liquid blending device applied to microfluidics provided by the invention can reduce the number of blending tools.

Moreover, with body 10 and power unit integrated structure, can make apparent improvement in the degree that the volume reduces, consequently, can effectually reduce the volume of blending instrument to solve the big technical problem of traditional blending instrument occupation space.

In addition, the liquid mixing device applied to the micro-fluidic system provided by the invention can ensure that the liquid to be mixed can flow back and forth between the solution cavity and the buffer cavity only by periodically pushing the liquid to be mixed to flow through the power mechanism. In the blending process, various blending tools are not required, and the operation flow is simple; the technical problem that the operation of the traditional blending tool is complex is solved, so that the operation process of blending the liquid can be effectively simplified.

In at least one embodiment, the liquid flow system 110 is hermetically disposed. It will be appreciated that the liquid flow system 110 may be sealingly disposed within the interior of the body. Accordingly, the power mechanism 20 is hermetically connected to the fluid flow system 110.

Therefore, the liquid blending device 1 applied to microfluidics provided by the first aspect can simplify the operation process of liquid blending through the liquid flowing system 110 and the power mechanism 20; meanwhile, the liquid flowing system 110 is arranged in a sealing manner, so that the mixing process of the liquid to be mixed can be realized in a closed space, the phenomenon of liquid leakage is avoided, and environmental pollution is avoided; in addition, the liquid mixing device 1 is applied to the microfluidic chip, so that the volume of a liquid mixing tool is reduced, and the occupied space of the liquid mixing device 1 is effectively reduced.

Further, as shown in fig. 3, in some embodiments, the liquid flow system further comprises an air chamber 113 in communication with the solution chamber 111; the power mechanism 20 includes a sliding member 210, and the sliding member 210 is slidably coupled in the air chamber 113. In the sliding path, the outer circumferential wall of the sliding member 210 is in interference contact with the inner side wall of the air chamber 113. Specifically, the air cavity 113 is communicated with the solution cavity 111, and further, the air cavity 113 may be communicated with the solution cavity 111 through an air passage 30, so that the pneumatic power generated by the power mechanism 20 can be continuously released through the air passage 30.

In some embodiments, the sliding member 210 is provided with a flexible sealing member on the outer circumferential wall, which connects the sliding member 210 and the air chamber 113 and enables the air chamber 113 to form a closed air chamber. The flexible sealing member may be made of silicone, rubber, or the like. Further, the sliding member 210 is integrally formed with the flexible sealing member.

In some embodiments, the sliding member 210 may be a suction glue.

Further, as shown in fig. 3, in some embodiments, the power mechanism 20 further includes a cam member 220. The cam member 220 is connected to the slide member 210. When the cam member 220 rotates, the sliding member 210 is driven to reciprocate. Specifically, the cam member 220 includes a wheel 221 and a wheel protrusion 222, and during the rotation of the cam member 220, when the wheel protrusion 222 abuts against the sliding member 210, the sliding member 210 is pushed to slide in the air cavity 113, so that a positive air pressure is generated in the air cavity 113; when the wheel protrusion 222 disengages the slide member 210, negative air pressure is generated by the slide member 210.

In some embodiments, as shown in fig. 3, the power mechanism 20 further includes a connecting member 230, one end of the connecting member 230 is connected to the sliding member 210, and the other end is used for connecting to the cam member 220 and receiving the power transmitted by the cam member 220. In some embodiments, the connecting member 230 may be a connecting rod.

Further, in some embodiments, the other end of the connecting member 230 extends to the periphery to form a connecting surface 231, the connecting surface 231 is connected to the cam member 220, and the connecting surface 231 is used to increase the contact area when being connected to the cam member 220.

Regarding the operation of the power mechanism 20, it can be realized in the following exemplary manner:

the cam member 220 is continuously rotated at a constant or non-constant speed, and when the protrusion 222 of the wheel in the cam member 220 contacts the connection member 230, the sliding member 210 is pushed to slide in the direction opposite to the cam member 220, so that the air chamber 113 generates positive air pressure, which is continuously released from the air passage 30, thereby enabling to push the liquid in the solution chamber 111 communicating with the air passage 30 to flow. When the protruding portion 222 of the wheel of the cam member 220 is gradually separated from the connecting member 230, the air chamber 113 generates negative air pressure, i.e., the air in the solution chamber 111 gradually flows into the air chamber 113, and the liquid flowing out of the solution chamber 111 is driven to flow back to the solution chamber 111, and in the process, the sliding member 210 and the connecting member 230 gradually return to the original positions.

Based on the foregoing, and as further shown in fig. 3, 4 and 5, the liquid flow system 110 further includes a carrier fluid component 114, a channel 115, a first fluid chamber 116 and a second fluid chamber 117. Wherein the carrier component 114 is slidably connected in the channel 115; the channel 115 is communicated with the solution cavity 111 and the buffer cavity 112; the first liquid cavity 116 is communicated with the cavity channel 115 and is used for loading a first liquid; the second liquid chamber 117 communicates with the channel 115 for carrying a second liquid.

In particular, the carrier liquid component 114 may be configured as a rectangular parallelepiped, but may be non-rectangular, such as cylindrical, in certain other embodiments. Further, a channel 1141 is disposed in the carrier liquid component 114, and the channel 1141 is used for transporting liquid. The channels 1141 may be configured as linear channels 1141, and in some other embodiments, may be configured in other shapes, such as curved; moreover, the size of the channel 1141 can be designed by those skilled in the art according to actual needs; furthermore, for design convenience, the flow direction of the channels 1141 may be perpendicular to the length direction of the carrier liquid component 114, but may be non-perpendicular in some other embodiments; in addition, both ends of the channel 1141 communicate with the outside of the carrier liquid component 114, respectively.

The shape of the channel 115 and the size of the inner space are matched with the carrier component 114, and after the carrier component 114 is slidably connected in the channel 115, the outer wall of the carrier component 114 is in interference connection with the inner wall of the channel 115. This design increases the seal between the channel 115 and the carrier component 114, preventing the liquid in the channel 1141 from flowing out of any gap that may be formed between the outer wall of the carrier component 114 and the inner wall of the channel 115.

Further, as shown in fig. 6, the channel 115 communicates with the buffer cavity 112 through the first flow channel 40; the channel 115 communicates with the solution chamber 111 through the second flow channel 50 and the third flow channel 60, respectively. Wherein the chamber 115 is disposed at the right of the first flow channel 40, the buffer chamber 112 is disposed at the left of the first flow channel 40, the chamber 115 is disposed at the left of the second flow channel 50 and the third flow channel 60, the solution chamber 111 is disposed at the right of the second flow channel 50 and the third flow channel 60, and the third flow channel 60 is disposed above the second flow channel. In the present application, the buffer chamber 112 and the solution chamber 111 may be respectively disposed at two sides of the channel 115, as shown in fig. 6. In addition, the first flow channel 40 and the second flow channel 50 may be configured as a straight flow channel, and the third flow channel 60 may be configured as a curved flow channel, and in some other embodiments, may be configured as other shapes; meanwhile, the first flow channel 40 and the second flow channel 50 may be symmetrically disposed, but may be designed to be asymmetrically disposed in some other embodiments.

As shown in fig. 5, the first fluid chamber 116 is configured to have a rectangular parallelepiped shape, and in some other embodiments, may be configured to have other non-rectangular parallelepiped shapes. The size of the inner space of the first liquid chamber 116 is smaller than that of the solution chamber 111. The purpose of this design is to avoid that when all the liquid in the first liquid chamber and the liquid in the channel 1141 flow into the solution chamber 111, the solution chamber 111 has insufficient space to accommodate the liquid in the first liquid chamber 116 and the liquid in the channel 1141. In some other embodiments, the size of the inner space of the first liquid chamber 116 may be larger than or equal to the size of the inner space of the solution chamber 111, and one skilled in the art can design the inner space according to the actual requirement. In addition, the first liquid chamber 116 is communicated with the channel 115 through a fourth flow channel 70, wherein the first liquid chamber 116 is arranged at the left of the fourth flow channel 70, and the channel 115 is arranged at the right of the fourth flow channel 70; the fourth flow channel 70 is configured as a straight flow channel, and in some other embodiments, may be designed as another shape, such as a curve. In the present application, the first fluid chamber 116 and the buffer chamber 112 may be on the same side of the channel 115.

The volume of the second chamber 117 is greater than the volume of the channel 1141. The purpose of this design is to avoid that no liquid can be transported through the channel 1141 during the sliding of the carrier component 114. When the volume of the second liquid chamber 117 is smaller than the volume of the channel 1141, the liquid in the second liquid chamber 117 is forced to flow toward the channel 1141, and all the liquid may flow through the channel 1141, so that no liquid can be transported through the channel 1141. In some other embodiments, it may be designed to be less than or equal to the capacity of the channel 1141. The second liquid chamber 117 is communicated with the chamber channel 115 through a fifth flow channel 80, and the second liquid chamber 117 is disposed at the left of the fifth flow channel 80. In the present application, the second fluid chamber 117 is on the same side of the channel 115 as the first fluid chamber 116 and the buffer chamber 112.

The first flow channel 40 is disposed below the fourth flow channel 70, and the fourth flow channel 70 is disposed below the fifth flow channel 80.

When the liquid blending device 1 is actually used, the carrier liquid component 114 is pushed to slide from the inlet of the channel 115 to the bottom direction (that is, slide from top to bottom in the drawing), when the channel 1141 slides to the third predetermined position P3 along with the carrier liquid component 114, as shown in fig. 4, the channel 1141 is communicated with the fifth flow channel 80, and at this time, the second liquid in the second liquid cavity 117 can flow into the channel 1141; on this basis, the carrier liquid component 114 is pushed continuously until the channel 1141 slides to a second predetermined position P2, as shown in fig. 5, the channel 1141 connects the third flow channel 60 and the fourth flow channel 70 to form a second flow path, in which case, the first liquid of the first liquid chamber 116 and the second liquid of the channel 1141 can flow into the solution chamber 111 through the second flow path to form the liquid to be mixed. Further, the carrier liquid component 114 is continuously pushed until the channel 1141 slides to the first predetermined position P1, as shown in fig. 6, the channel 1141 connects the first flow channel 40 and the second flow channel 50 to form a first flow path, at this time, the liquid to be mixed in the solution cavity 111 may flow into the buffer cavity 112 through the first flow path, or after the above process, the liquid to be mixed in the buffer cavity 112 may flow back into the solution cavity 111 through the first flow path.

It should be noted that the first liquid chamber 116 and the second liquid chamber 117 may be sealed; in particular, may be sealingly arranged inside the body.

Further, as shown in fig. 1, in some embodiments, the body 10 further includes a substrate 120 and a cover 130; the liquid flow system is disposed in the substrate 120, and the cover 130 covers the substrate 120 for sealing the liquid flow system. In the present application, the fluid flowing system 110 is disposed inside the substrate 120, and the actuating mechanism 20 extends from the inside of the substrate 120 to the outside of the substrate 120. Specifically, the sliding member 210 of the power mechanism 20 is slidably connected to the air cavity 113 inside the base plate 120, the sliding member 210 extends from the inside of the base plate 120 to the outside of the base plate 120, the sliding member 210 is connected to the connecting member 230 of the power mechanism 20 outside the base plate 120, and the connecting member 230 is connected to the cam member 220 of the power mechanism 20.

Based on the foregoing, in some embodiments, the liquid flowing system 110 may include a plurality of solution chambers, a plurality of buffer chambers, and a plurality of first liquid chambers, and the number of corresponding flow channels communicating with the above chambers is adapted to the number of each chamber; the power mechanism can comprise a plurality of air cavities and a plurality of sliding components, and the number of the air passages communicated with the air cavities is matched with that of the air cavities. Specifically, in fig. 7, the number of the plurality of solution cavities is 2, correspondingly, the number of the plurality of buffer cavities is 2, the number of the plurality of first liquid cavities is 2, the number of the plurality of air cavities is 2, the number of the plurality of sliding members is 2, 4 flow channels are added to the flow channels compared with the above flow channels, and 1 air channel is added to the above flow channels compared with the above flow channels, so that 2 sets of units capable of uniformly mixing the liquid to be uniformly mixed are integrated in the liquid uniformly mixing device.

< microfluidic chip >

A second aspect of the present invention provides a microfluidic chip, including:

the invention relates to a liquid mixing device applied to a micro-fluidic chip in a first aspect. In the microfluidic chip provided by the invention, the liquid to be mixed can be quickly and uniformly mixed only by installing the liquid mixing device applied to the microfluidic chip in the first aspect.

While embodiments of the invention have been described above, it is not limited to the applications set forth in the description and the embodiments, which are fully applicable to various fields of endeavor for which the invention may be embodied with additional modifications as would be readily apparent to those skilled in the art, and the invention is therefore not limited to the details shown and described herein without departing from the general concept defined by the claims and their equivalents.