阅读说明：本技术 一种基于低能量冲击波的休眠血管激活方法 (Dormant blood vessel activation method based on low-energy shock wave ) 是由 于庆君 于 2021-08-05 设计创作，主要内容包括：本发明涉及低能量冲击波治疗的技术领域,且公开了一种基于低能量冲击波的休眠血管激活方法,通过低能量冲击波治疗急性心肌梗死,梗死心肌局部血管内皮生长因子mRNA表达水平上升,血管内皮细胞数量和毛细血管密度明显增加,促进侧支循环的发育,提示ESW可有效诱导缺血区血管新生,重建局部心肌微循环,改善心梗后心室重塑,同时低能量冲击波在治疗后血浆中一氧化氮水平明显升高,成纤维细胞生长因子、胰岛素样生长因子明显升高,而转化生长因子一p1、可溶性细胞间粘附因子、可溶性血管细胞粘附因子一1均降低-121,说明低能量冲击波的局部治疗可明显升高血浆NO水平,起到抗炎作用,使病变区域的新陈代谢得到改善,促进微血管生成。(The invention relates to the technical field of low-energy shock wave treatment, and discloses a dormant blood vessel activation method based on low-energy shock waves, acute myocardial infarction is treated by the low-energy shock waves, the mRNA expression level of local vascular endothelial growth factor of infarcted myocardium is increased, the number of vascular endothelial cells and the density of capillaries are obviously increased, the development of collateral circulation is promoted, ESW is prompted to effectively induce angiogenesis of an ischemic area, local myocardial microcirculation is reconstructed, ventricular remodeling after the myocardial infarction is improved, meanwhile, the nitric oxide level in plasma is obviously increased after the low-energy shock waves are treated, the fibroblast growth factor and the insulin-like growth factor are obviously increased, the transforming growth factor p1, the soluble intercellular adhesion factor and the soluble vascular cell adhesion factor 1 are all reduced to 121, which shows that the local treatment of the low-energy shock waves can obviously increase the NO level of the plasma, has anti-inflammatory effect, and can improve metabolism of pathological change region and promote generation of capillary vessel.)

1. A dormant blood vessel activation method based on low-energy shock waves comprises the following steps:

(a) the low-energy shock wave therapeutic apparatus is adopted to treat the blood vessel of the patient needing to be activated, and the low-energy shock wave therapeutic apparatus is transmitted in a three-dimensional space by transmitting the frequency of sound waves, wherein the transmission speed is increased along with the increase of pressure;

(b) when the low-energy shock wave is used for treating a patient, a mechanical stress effect can be generated, and a biomechanical effect is generated by mechanical stimulation, so that the device has the functions of promoting cell proliferation and metabolism, stimulating the regeneration of microvessels and enhancing the tissue repair capacity;

(c) the stress piezoelectric effect is that when low-energy shock waves are propagated in a heterogeneous object, a tension gradient is formed due to the difference of acoustic characteristics and mechanical characteristics of a medium, shearing force is generated inside the object, stress action is generated on tissues and cells, and the potential of a lesion position is changed;

(d) the high-energy shock wave enables small bubbles contained in the medium to expand rapidly, promotes the repair and regeneration of the microvasculature in the myocardium, and can promote the regeneration of the blood vessel to form a new capillary vessel on the basis of the original microvasculature;

(e) the low-energy shock wave causes a metabolism activation effect, possibly caused by a direct mechanical effect, on one hand, the pressure wave can change an ion channel to change the polarity of a neural membrane and generate an analgesic effect by inhibiting depolarization, and on the other hand, the pressure wave can activate the ion exchange process inside and outside cells to accelerate the removal and absorption of end products of metabolic decomposition;

(f) the irradiation energy of the shock wave is 0.03-0.12 mJ/mm 2, which is about 1/10 of the energy used by common gravels, after the organism is treated by the low-energy shock wave, the tissue damage caused by the shock wave can not occur, and the apoptosis of tissue cells and the infiltration quantity of inflammatory cells can not be influenced, so the tissue damage can not be induced by the low-energy shock wave treatment.

2. The method for activating dormant blood vessels based on low-energy shock waves according to claim 1, wherein: in the process of conducting the low-energy shock wave, reflection and refraction are formed between material interfaces with different acoustic impedances, energy attenuation is formed inside the material, the absorption energy is more when the impedance is large, the absorption energy is less when the impedance is small, and different effects are formed.

3. The method for activating dormant blood vessels based on low-energy shock waves according to claim 1, wherein: the low-energy shock wave is used for treating acute myocardial infarction, the mRNA expression level of local vascular endothelial growth factor of infarcted myocardium is increased, the number of vascular endothelial cells and the density of capillary vessels are obviously increased, the development of collateral circulation is promoted, ESW is prompted to effectively induce angiogenesis in an ischemic area, local myocardial microcirculation is reconstructed, ventricular remodeling after myocardial infarction is improved, meanwhile, the nitric oxide level in plasma is obviously increased after the low-energy shock wave is treated, fibroblast growth factor and insulin-like growth factor are obviously increased, and transforming growth factor p1, soluble intercellular adhesion factor and soluble vascular cell adhesion factor 1 are all reduced by _121, so that the plasma NO level can be obviously increased through local treatment of the low-energy shock wave, the anti-inflammatory effect is achieved, the metabolism of a lesion area is improved, and the generation of the capillary vessels is promoted.

4. The method of claim 3, wherein the activation of the dormant vessel is based on a low energy shock wave: the low-energy shock wave treatment promotes vascular proliferation of an ischemic area, relieves the injury caused by inflammatory reaction and oxidative stress, and can effectively improve ischemic left ventricular dysfunction and left ventricular remodeling.

5. The method for activating dormant blood vessels based on low-energy shock waves according to claim 1, wherein: the heart disease treatment has evidence of myocardial ischemia for patients and is not suitable for percutaneous coronary intervention and coronary artery bypass surgery, the Canadian cardiovascular society angina severity grades are II-IV, low energy shock wave treatment can be considered, the low energy shock wave treatment can improve the symptoms of the patients and reduce the use of nitroglycerin, dipyridamole load myocardial nuclide scanning shows that the ischemia is improved, part of cases can see the enhancement of wall motion, the effectiveness can last for at least 12 months, compared with before treatment, after 6 months of treatment, the cardiac function grading is obviously reduced, the symptoms are obviously relieved, the angina stable condition of the patients and the satisfaction degree of the treatment method are obviously improved, nuclide myocardial imaging shows that the myocardial regional blood perfusion after 6 months of treatment is obviously increased, the ischemic segments are reduced, low energy shock wave therapy is a safe, viable option for treating patients with advanced coronary heart disease, diffuse vasculopathy, and unsuitability for traditional myocardial revascularization therapy.

6. The method for activating dormant blood vessels based on low-energy shock waves according to claim 1, wherein: compared with the treatment before, the low-energy shock wave treatment for treating the heart failure patients caused by the ischemic cardiomyopathy has the advantages that the cardiac function grading of the new york cardiology is obviously reduced after 6 months of treatment, the left ventricular ejection fraction is obviously increased, the myocardial perfusion in the diastole and the end systole of the treatment section is obviously increased, the wall motion of the treatment section is enhanced, no adverse event occurs during the treatment, and the low-energy shock wave treatment has potential application value in the aspect of improving the heart function of the heart failure patients with the ischemic cardiomyopathy.

7. The method for activating dormant blood vessels based on low-energy shock waves according to claim 1, wherein: the vascular wall stenosis degree is obviously reduced after the low-energy shock wave treatment, so that the treatment process of PAD is promoted, a refractory lower limb ulcer caused by unsmooth venous return can be successfully cured by the low-energy shock wave, lymphatic return can be promoted by the application of the low-energy shock wave, and the low-energy shock wave treatment is a safe and effective physical treatment method for treating the refractory ulcer.

Technical Field

The invention relates to the technical field of low-energy shock wave treatment, in particular to a dormant blood vessel activation method based on low-energy shock waves.

Background

In recent years, the incidence rate of ischemic heart disease is gradually increased, the treatment of ischemic heart disease is greatly developed, the current drug therapy and percutaneous coronary intervention are three main methods of clinical treatment, but the prognosis of various treatments is poor for some patients with ischemic heart disease without the treatment indications. On one hand, the symptoms of angina pectoris are difficult to control, and on the other hand, due to low cardiac function and enlarged heart caused by myocardial ischemia, the extracorporeal shock wave is a safe, economic and reliable treatment method superior to other minimally invasive non-invasive human-based treatment technologies and widely applied to treatment of diseases such as urology surgery, andrology, orthopedics and the like, so that a treatment method for activating blood vessels by low-energy shock waves is urgently needed.

Disclosure of Invention

Technical problem to be solved

Aiming at the defects of the prior art, the invention provides a dormant blood vessel activation method based on low-energy shock waves, and solves the problem.

(II) technical scheme

In order to improve the metabolism of the lesion area and promote the generation of the micro-blood vessels. The invention provides the following technical scheme: a dormant blood vessel activation method based on low-energy shock waves comprises the following steps: a dormant blood vessel activation method based on low-energy shock waves comprises the following steps:

(a) the low-energy shock wave therapeutic apparatus is adopted to treat the blood vessel of the patient needing to be activated, and the low-energy shock wave therapeutic apparatus is transmitted in a three-dimensional space by transmitting the frequency of sound waves, wherein the transmission speed is increased along with the increase of pressure;

(b) when the low-energy shock wave is used for treating a patient, a mechanical stress effect can be generated, and a biomechanical effect is generated by mechanical stimulation, so that the device has the functions of promoting cell proliferation and metabolism, stimulating the regeneration of microvessels and enhancing the tissue repair capacity;

(c) the stress piezoelectric effect is that when low-energy shock waves are propagated in a heterogeneous object, a tension gradient is formed due to the difference of acoustic characteristics and mechanical characteristics of a medium, shearing force is generated inside the object, stress action is generated on tissues and cells, and the potential of a lesion position is changed;

(d) the high-energy shock wave enables small bubbles contained in the medium to expand rapidly, promotes the repair and regeneration of the microvasculature in the myocardium, and can promote the regeneration of the blood vessel to form a new capillary vessel on the basis of the original microvasculature;

(e) the low-energy shock wave causes a metabolism activation effect, possibly caused by a direct mechanical effect, on one hand, the pressure wave can change an ion channel to change the polarity of a neural membrane and generate an analgesic effect by inhibiting depolarization, and on the other hand, the pressure wave can activate the ion exchange process inside and outside cells to accelerate the removal and absorption of end products of metabolic decomposition;

(f) the irradiation energy of the shock wave is 0.03-0.12 mJ/mm 2, which is about 1/10 of the energy used by common gravels, after the organism is treated by the low-energy shock wave, the tissue damage caused by the shock wave can not occur, and the apoptosis of tissue cells and the infiltration quantity of inflammatory cells can not be influenced, so the tissue damage can not be induced by the low-energy shock wave treatment.

Preferably, in the process of conducting the low-energy shock wave, reflection and refraction are formed between material interfaces with different acoustic impedances, energy attenuation is formed inside the material, the absorption energy with high impedance is more, the absorption energy with low impedance is less, and different effects are formed.

Preferably, the low-energy shock wave is used for treating acute myocardial infarction, the mRNA expression level of local vascular endothelial growth factor of infarcted myocardium is increased, the number of vascular endothelial cells and the density of capillaries are obviously increased, the development of collateral circulation is promoted, ESW is prompted to effectively induce angiogenesis in an ischemic area, local myocardial microcirculation is reconstructed, ventricular remodeling after myocardial infarction is improved, meanwhile, the nitric oxide level in plasma is obviously increased after the low-energy shock wave is treated, the fibroblast growth factor and the insulin-like growth factor are obviously increased, and the transforming growth factor p1, the soluble intercellular adhesion factor and the soluble vascular cell adhesion factor 1 are all reduced to _121, so that the plasma NO level can be obviously increased through local treatment of the low-energy shock wave, the anti-inflammatory effect is achieved, the metabolism of a diseased region is improved, and the generation of capillaries is promoted.

Preferably, the low-energy shock wave treatment promotes vascular proliferation in the ischemic region, reduces inflammatory reactions and injuries caused by oxidative stress, and can effectively improve ischemic left ventricular dysfunction and left ventricular remodeling.

Preferably, the treatment of the heart disease has evidence of myocardial ischemia for a patient and is not suitable for percutaneous coronary intervention and coronary artery bypass surgery, the Canadian society of cardiovascular society has angina severity grade II-IV, low energy shock wave treatment can be considered, the low energy shock wave treatment can improve the symptoms of the patient, the use of nitroglycerin is reduced, the dipyridamole load myocardial nuclide scanning shows that ischemia is improved, the enhancement of wall motion can be seen in some cases, the effectiveness can last for at least 12 months, after 6 months of treatment, the cardiac function grading is obviously reduced compared with before treatment, the symptoms are obviously relieved, the stable condition of the angina of the patient is obviously improved, the satisfaction degree of the treatment method is obviously improved, nuclide myocardial imaging shows that the blood perfusion in the myocardial area after 6 months of treatment is obviously increased, the ischemic segments are reduced, low energy shock wave therapy is a safe, viable option for treating patients with advanced coronary heart disease, diffuse vasculopathy, and unsuitability for traditional myocardial revascularization therapy.

Preferably, the low-energy shock wave treatment for the heart failure patients caused by the ischemic cardiomyopathy has the advantages that the cardiac function grading of the new york cardiology is obviously reduced after 6 months of treatment, the left ventricular ejection fraction is obviously increased, the diastolic and end-systolic myocardial perfusion of the treatment segment is obviously increased, the wall motion of the treatment segment is enhanced, no adverse event occurs during the treatment, and the low-energy shock wave treatment has potential application value in improving the heart function of the ischemic cardiomyopathy heart failure patients.

Preferably, the vascular wall stenosis degree is obviously reduced after the low-energy shock wave treatment, so that the treatment process of PAD is promoted, the low-energy shock wave successfully cures intractable lower limb ulcer caused by unsmooth venous return, lymphatic return can be promoted by the application of the low-energy shock wave, and the low-energy shock wave treatment is a safe and effective physical treatment method for treating intractable ulcer.

(III) advantageous effects

Compared with the prior art, the invention provides a dormant blood vessel activation method based on low-energy shock waves, which has the following beneficial effects:

1. the dormant blood vessel activation method based on the low-energy shock wave treats acute myocardial infarction through the low-energy shock wave, the mRNA expression level of local vascular endothelial growth factor of infarcted myocardium is increased, the number of vascular endothelial cells and the density of capillary vessels are obviously increased, the development of collateral circulation is promoted, ESW is prompted to effectively induce angiogenesis in an ischemic area, local myocardial microcirculation is rebuilt, ventricular remodeling after myocardial infarction is improved, meanwhile, the nitric oxide level in plasma is obviously increased after the low-energy shock wave is treated, the fibroblast growth factor and the insulin-like growth factor are obviously increased, a transforming growth factor p1, a soluble intercellular adhesion factor and a soluble vascular cell adhesion factor 1 are all reduced to 121, the partial treatment of the low-energy shock wave can obviously increase the NO level of the plasma, the anti-inflammatory effect is achieved, and the metabolism of a lesion area is improved, promoting the generation of micro-blood vessels.

2. According to the dormant blood vessel activation method based on the low-energy shock wave, reflection and refraction are formed between material interfaces with different acoustic impedances in the conduction process of the low-energy shock wave, energy attenuation is formed inside the material, the absorption energy is more when the impedance is large, the absorption energy is less when the impedance is small, and different effects are formed.

3. The dormant blood vessel activation method based on the low-energy shock wave promotes vascular proliferation of an ischemic region through low-energy shock wave treatment, relieves injury caused by inflammatory reaction and oxidative stress, and can effectively improve ischemic left ventricular dysfunction and left ventricular remodeling.

4. The dormant blood vessel activating method based on the low-energy shock wave can improve the symptoms of patients through the low-energy shock wave treatment, reduce the use of nitroglycerin, improve ischemia as shown by dipyridamole loading myocardial nuclide scanning, enhance the wall motion in some cases, and the effectiveness can last for at least 12 months, compared with before-treatment, after 6 months of treatment, the cardiac function grading is obviously reduced, the symptom is obviously relieved, the angina pectoris of the patient is stable, the satisfaction degree of the treatment method is obviously improved, nuclide myocardial imaging shows that the blood perfusion of the myocardial area after 6 months of treatment is obviously increased, the ischemic segment is reduced, and the low-energy shock wave treatment is safe and feasible for patients who are treated in the late coronary heart disease and the diffuse angiopathy and are not suitable for the traditional myocardial revascularization treatment.

5. According to the low-energy shock wave based dormant blood vessel activation method, a heart failure patient caused by ischemic cardiomyopathy is treated by the low-energy shock wave, compared with the treatment before, the cardiac function grading of New York cardiology is obviously reduced after 6 months of treatment, the left ventricular ejection fraction is obviously increased, the myocardial perfusion of a treatment section in diastole and systole end is obviously increased, the wall motion of the treatment section is enhanced, no adverse event occurs during the treatment, and the low-energy shock wave treatment has potential application value in the aspect of improving the heart function of the ischemic cardiomyopathy heart failure patient.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

A dormant blood vessel activation method based on low-energy shock waves comprises the following steps: a dormant blood vessel activation method based on low-energy shock waves comprises the following steps: a dormant blood vessel activation method based on low-energy shock waves comprises the following steps:

(a) the low-energy shock wave therapeutic apparatus is used for treating the blood vessel of a patient needing to be activated, the shock wave is transmitted in a three-dimensional space by transmitting sound wave frequency, the transmission speed is increased along with the increase of pressure, the low-energy shock wave forms reflection and refraction between material interfaces with different acoustic impedances in the transmission process, energy attenuation is formed in the material, the absorption energy with large impedance is more, the absorption energy with small impedance is less, and different effects are formed;

(b) when the low-energy shock wave is used for treating a patient, a mechanical stress effect is generated, a biomechanical effect is generated by mechanical stimulation, the low-energy shock wave has the effects of promoting cell proliferation and metabolism, stimulating the regeneration of capillaries and enhancing the tissue repair capacity, the low-energy shock wave is used for treating acute myocardial infarction, the mRNA expression level of local vascular endothelial growth factor of infarcted myocardium is increased, the number of vascular endothelial cells and the density of capillary vessels are obviously increased, the development of collateral circulation is promoted, ESW is prompted to effectively induce angiogenesis in an ischemic area, local myocardial microcirculation is reconstructed, ventricular remodeling after myocardial infarction is improved, the nitric oxide level of the low-energy shock wave in blood plasma is obviously increased after treatment, the fibroblast growth factor and the insulin-like growth factor are obviously increased, and the transforming growth factor-p 1, the intercellular soluble adhesion factor and the soluble vascular cell adhesion factor-1 are all reduced to-121, the local treatment of the low-energy shock wave can obviously increase the NO level of blood plasma, has the anti-inflammatory effect, improves the metabolism of a lesion area and promotes the generation of micro-blood vessels;

(c) the stress piezoelectric effect, the low energy shock wave forms a tension gradient due to the difference of acoustic characteristics and mechanical characteristics of a medium when propagating in a heterogeneous object, the shear force is generated in the object, the stress effect is generated on tissues and cells, the potential of a lesion is changed, the low energy shock wave treatment promotes the vascular proliferation of an ischemic area, the injury caused by inflammatory reaction and oxidative stress is relieved, ischemic left ventricular dysfunction and left ventricular remodeling can be effectively improved, the heart disease treatment has evidence of myocardial ischemia on a patient and is not suitable for percutaneous coronary artery intervention and coronary artery bypass surgery, the severity of angina pectoris of Canadian cardiovascular society is classified into II-IV grade, the low energy shock wave treatment can be considered and applied, the low energy shock wave treatment can improve the symptoms of the patient, the use of nitroglycerin is reduced, and the dipyridamole load myocardial nuclide scanning shows that the ischemia is improved, in some cases, the enhancement of wall motion can be seen, the effectiveness can last for at least 12 months, after the low-energy shock wave treatment, compared with before the treatment, the classification of cardiac function is obviously reduced after 6 months of treatment, the symptoms are obviously relieved, the stable situation of angina pectoris of a patient is obviously improved, the satisfaction degree of the treatment method is obviously improved, the imaging of nuclide myocardium shows that the blood perfusion of a myocardial area after 6 months of treatment is obviously increased, the ischemic segment is reduced, and the low-energy shock wave treatment is safe and feasible for patients who treat late coronary heart disease, diffuse angiopathy and are not suitable for the traditional myocardial revascularization treatment;

(d) the high-energy shock wave enables small bubbles in a medium to expand rapidly, promotes the restoration and regeneration of cardiac microvasculature, and can promote the regeneration of blood vessels to form new capillary vessels on the basis of the original microvasculature, the low-energy shock wave treats a heart failure patient caused by ischemic cardiomyopathy, compared with the treatment before, the cardiac function grading of New York cardiology after 6 months of treatment is obviously reduced, the left ventricular ejection fraction is obviously increased, the myocardial perfusion in the diastole and the systole of a treatment section is obviously increased, the wall motion of the treatment section is enhanced, no adverse event occurs in the treatment period, the low-energy shock wave treatment has potential application value in the aspect of improving the cardiac function of the heart failure patient with ischemic cardiomyopathy, the stenosis degree of the blood vessel wall after the low-energy shock wave treatment is obviously reduced, so that the treatment process of PAD is promoted, and the low-energy shock wave successfully cures a refractory lower limb ulcer caused by unsmooth venous return, the application of low-energy shock waves can promote lymphatic return, and the low-energy shock wave treatment is a safe and effective physical treatment method for treating intractable ulcer;

(e) the low-energy shock wave causes a metabolism activation effect, on one hand, the pressure wave can change an ion channel to change the polarity of a neural membrane and generate an analgesic effect by inhibiting the depolarization effect, and on the other hand, the pressure wave can activate the ion exchange process inside and outside cells to accelerate the removal and absorption of the final products of metabolic decomposition;

(f) the irradiation energy of the shock wave is 0.03-0.12 mJ/mm 2, which is about 1/10 of the energy used by common gravels, after the organism is treated by the low-energy shock wave, the tissue damage caused by the shock wave can not occur, and the apoptosis of tissue cells and the infiltration quantity of inflammatory cells can not be influenced, so the tissue damage can not be induced by the low-energy shock wave treatment.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.