阅读说明：本技术 一种u型管快速给药系统及控制方法 (U-shaped tube rapid drug delivery system and control method ) 是由 吴杰 于 2021-08-12 设计创作，主要内容包括：本发明公开了一种U型管快速给药系统,包括U型管、给药装置、夹管装置、负压装置,给药装置包括若干给药管,并且若干给药管分别与U型管之间连接有若干输液,夹管装置包括对应若干给药管设置有若干夹管阀,用于分别控制若干输液管的导通、闭合,负压装置与U型管之间通过管道连接,使给药管内的药物在负压装置的作用下填满U型管,U型管的弯曲底面具有出液孔,U型管的出口端具有负压阀门,当负压阀门关闭时,U型管内的药物喷射至培养皿上,当负压阀门打开时,给药管内的清洗液在负压装置的作用下对U型管进行冲洗。通过本发明实现快速给药、清洗及换药的工作,有效节省实验时间,提高实验效率。(The invention discloses a U-shaped tube rapid drug delivery system, which comprises a U-shaped tube, a drug delivery device, a tube clamping device and a negative pressure device, wherein the drug delivery device comprises a plurality of drug delivery tubes, a plurality of transfusions are respectively connected between the drug delivery tubes and the U-shaped tube, the tube clamping device comprises a plurality of tube clamping valves arranged corresponding to the drug delivery tubes and used for respectively controlling the conduction and the closure of a plurality of infusion tubes, the negative pressure device is connected with the U-shaped tube through a pipeline, so that drugs in the drug delivery tubes are filled in the U-shaped tube under the action of the negative pressure device, a liquid outlet hole is formed in the bent bottom surface of the U-shaped tube, a negative pressure valve is arranged at the outlet end of the U-shaped tube, when the negative pressure valve is closed, the drugs in the U-shaped tube are sprayed onto a culture dish, and when the negative pressure valve is opened, cleaning liquid in the drug delivery tubes washes the U-shaped tube under the action of the negative pressure device. The invention realizes the work of quick drug administration, cleaning and drug change, effectively saves the experimental time and improves the experimental efficiency.)

1. A U-tube rapid drug delivery system, comprising:

a U-shaped pipe;

the drug delivery device comprises a plurality of drug delivery tubes, and a plurality of infusion tubes are connected between the drug delivery tubes and the U-shaped tube respectively;

the tube clamping device comprises a plurality of tube clamping valves which are arranged corresponding to the plurality of administration tubes and are used for respectively controlling the conduction and the closure of the plurality of infusion tubes;

the negative pressure device is connected with the U-shaped pipe through a pipeline, so that the U-shaped pipe is filled with the medicine in the administration pipe under the action of the negative pressure device, a liquid outlet hole is formed in the bent bottom surface of the U-shaped pipe, a negative pressure valve is arranged at the outlet end of the U-shaped pipe, when the negative pressure valve is closed, the medicine in the U-shaped pipe is sprayed onto a culture dish, and when the negative pressure valve is opened, the U-shaped pipe is washed by the cleaning liquid in the administration pipe under the action of the negative pressure device.

2. The U-shaped tube rapid drug delivery system according to claim 1, wherein the negative pressure device comprises a drug delivery negative pressure pump, a first lead-in tube is connected between the air inlet end of the drug delivery negative pressure pump and the outlet end of the U-shaped tube, and a first lead-out tube is connected between the waste liquid bottle and the air outlet end of the drug delivery negative pressure pump.

3. The U-tube rapid drug delivery system according to claim 2, further comprising a waste liquid bottle for storing waste liquid in the culture dish, and a rinsing bottle for storing rinsing liquid for rinsing the culture dish.

4. The U-shaped tube rapid drug delivery system according to claim 3, wherein the negative pressure device further comprises a flushing suction pump and a liquid drainage suction pump, a second outlet tube is connected between the air outlet end of the flushing suction pump and the culture dish, a second inlet tube is connected between the flushing bottle and the air inlet end of the flushing suction pump, a third inlet tube is connected between the air inlet end of the liquid drainage suction pump and the culture dish, and a third outlet tube is connected between the waste liquid bottle and the air outlet end of the liquid drainage suction pump.

5. The U-tube rapid drug delivery system according to claim 1, wherein a catheter is fixedly arranged on the inlet end of the U-tube, and the infusion tube is inserted into the catheter.

6. The U-tube rapid drug delivery system according to any one of claims 1 to 5, further comprising a control module electrically connected to the pinch valve, the negative pressure drug delivery pump, the irrigation suction pump, and the drainage suction pump, respectively.

7. The U-shaped tube rapid drug delivery system according to claim 6, wherein the control module is provided with a plurality of buttons, and the plurality of buttons are electrically connected with the control module and used for controlling the operation of the pinch valve, the drug delivery negative pressure pump, the irrigation suction pump and the drainage suction pump.

8. The method for controlling a rapid U-tube administration system according to claim 7, comprising the steps of:

step one, inputting the medicine and the cleaning fluid into corresponding administration tubes respectively to finish preparation work;

step two, pressing the button No. 1, and then opening a pinch valve and a dosing negative pressure pump corresponding to the drug delivery tube No. 1 by the control module, so that the drug in the drug delivery tube No. 1 is fed into the U-shaped tube through the infusion tube under the action of the dosing negative pressure pump;

step three, closing a negative pressure valve on the U-shaped pipe to enable the medicine in the U-shaped pipe to be sprayed into the culture dish from the liquid outlet hole;

step four, after the dosing is finished, pressing a button No. 2, controlling a valve to open a pinch valve corresponding to the dosing tube No. 2, simultaneously opening a negative pressure valve on the U-shaped tube, enabling cleaning liquid in the dosing tube No. 2 to enter the U-shaped tube through a liquid conveying tube under the action of a dosing negative pressure pump, enabling the cleaning liquid in the dosing tube No. 2 to clean the U-shaped tube, and discharging the cleaning liquid into a waste liquid bottle through a first lead-in tube and a second lead-out tube;

and step five, pressing a No. 5 button, controlling the administration negative pressure pump to stop working by the control module, starting the irrigation suction pump and the liquid drainage suction pump, flushing the culture dish by flushing liquid in the irrigation bottle through the second guide pipe under the action of the irrigation suction pump, and inputting the waste liquid in the culture dish into a waste liquid bottle through the third guide pipe under the action of the liquid drainage suction pump when the waste liquid in the culture dish is higher than the third guide pipe of the liquid drainage suction pump.

9. The method as claimed in claim 8, wherein the time for flushing the U-shaped tube in the fourth step is not less than 10 seconds.

Technical Field

The invention relates to the technical field of medical equipment, in particular to a U-shaped tube rapid drug delivery system and a control method.

Background

In the cell recording system of the patch clamp, including one is placed on the cell of the experiment operation panel, the culture dish is to offer and maintain the living cell to survive for a long time and drive the place that the extracellular fluid exchanges, this kind of exchange is injected into the living cell or slice in the culture dish by the charge device and accords with different requirements, extracellular fluid saturated by oxygen, or inject the extracellular fluid mixed with pharmaceutical composition of different solubility, after fully acting on the cell, carry on the patch clamp experiment to the cell or slice by the experimenter, because the extracellular fluid of different pharmaceutical compositions need to be injected into in the experiment of the patch clamp, therefore need wash the charge device when changing the liquid in every experimental process, and the existing liquid changing effect is general, can't reach and change the liquid and wash fast, thus greatly increased experimental time and efficiency.

Disclosure of Invention

The technical problem to be solved by the embodiment of the invention is to provide a U-shaped tube rapid drug delivery system and a control method, so that the rapid drug delivery, cleaning and dressing change work is realized, the experiment time is effectively saved, and the experiment efficiency is improved.

In order to achieve the above object, the present invention discloses a rapid drug delivery system with a U-tube, comprising:

a U-shaped pipe;

the drug delivery device comprises a plurality of drug delivery tubes, and a plurality of infusion tubes are connected between the drug delivery tubes and the U-shaped tube respectively;

the tube clamping device comprises a plurality of tube clamping valves which are arranged corresponding to the plurality of administration tubes and are used for respectively controlling the conduction and the closure of the plurality of infusion tubes;

the negative pressure device is connected with the U-shaped pipe through a pipeline, so that the U-shaped pipe is filled with the medicine in the administration pipe under the action of the negative pressure device, a liquid outlet hole is formed in the bent bottom surface of the U-shaped pipe, a negative pressure valve is arranged at the outlet end of the U-shaped pipe, when the negative pressure valve is closed, the medicine in the U-shaped pipe is sprayed onto a culture dish, and when the negative pressure valve is opened, the U-shaped pipe is washed by the cleaning liquid in the administration pipe under the action of the negative pressure device.

Preferably, the negative pressure device comprises a dosing negative pressure pump, a first lead-in pipe is connected between the air inlet end of the dosing negative pressure pump and the outlet end of the U-shaped catheter, and a first lead-out pipe is connected between the waste liquid bottle and the air outlet end of the dosing negative pressure pump.

Preferably, the culture dish washing device further comprises a waste liquid bottle and a washing bottle, wherein the waste liquid bottle is used for storing waste liquid in the culture dish, and the washing bottle is used for storing washing liquid for washing the culture dish.

Preferably, the negative pressure device further comprises a flushing suction pump and a liquid drainage suction pump, a second guide pipe is connected between the air outlet end of the flushing suction pump and the culture dish, a second guide pipe is connected between the flushing bottle and the air inlet end of the flushing suction pump, a third guide pipe is connected between the air inlet end of the liquid drainage suction pump and the culture dish, and a third guide pipe is connected between the waste liquid bottle and the air outlet end of the liquid drainage suction pump.

Preferably, a guide tube is fixedly arranged at the inlet end of the U-shaped tube, and the infusion tubes are all inserted into the guide tube.

Preferably, the device further comprises a control module, and the control module is respectively electrically connected with the pinch valve, the administration negative pressure pump, the irrigation negative pressure pump and the recovery negative pressure pump.

Preferably, the control module is provided with a plurality of buttons, and the buttons are respectively electrically connected with the control module and are used for controlling the operation of the pinch valve, the administration negative pressure pump, the irrigation suction pump and the liquid drainage suction pump.

Preferably, the invention also provides a control method of the U-shaped tube rapid drug delivery system, which comprises the following steps:

step one, inputting the medicine and the cleaning fluid into corresponding administration tubes respectively to finish preparation work;

step two, pressing the button No. 1, and then opening a pinch valve and a dosing negative pressure pump corresponding to the drug delivery tube No. 1 by the control module, so that the drug in the drug delivery tube No. 1 is fed into the U-shaped tube through the infusion tube under the action of the dosing negative pressure pump;

step three, closing a negative pressure valve on the U-shaped pipe to enable the medicine in the U-shaped pipe to be sprayed into the culture dish from the liquid outlet hole;

step four, after the dosing is finished, pressing a button No. 2, controlling a valve to open a pinch valve corresponding to the dosing tube No. 2, simultaneously opening a negative pressure valve on the U-shaped tube, enabling cleaning liquid in the dosing tube No. 2 to enter the U-shaped tube through a liquid conveying tube under the action of a dosing negative pressure pump, enabling the cleaning liquid in the dosing tube No. 2 to clean the U-shaped tube, and discharging the cleaning liquid into a waste liquid bottle through a first lead-in tube and a second lead-out tube;

and step five, pressing a No. 5 button, controlling the administration negative pressure pump to stop working by the control module, starting the irrigation suction pump and the liquid drainage suction pump, flushing the culture dish by flushing liquid in the irrigation bottle through the second guide pipe under the action of the irrigation suction pump, and inputting the waste liquid in the culture dish into a waste liquid bottle through the third guide pipe under the action of the liquid drainage suction pump when the waste liquid in the culture dish is higher than the third guide pipe of the liquid drainage suction pump.

Preferably, the time for flushing the U-shaped pipe in the fourth step is not less than 10 seconds.

Compared with the prior art, the invention has the beneficial effects that:

according to the U-shaped pipe, the liquid outlet hole is formed in the bent bottom surface of the U-shaped pipe, the administration pipe can be used for administering the medicine to the U-shaped pipe and washing the U-shaped pipe by being connected with the negative pressure pump, the medicine is sprayed out through the liquid outlet hole of the U-shaped pipe during administration, and the medicine is discharged into a waste liquid bottle through the outlet end of the U-shaped pipe during washing, so that the U-shaped pipe is quickly administered and washed;

when the U type pipe in the flushing process, can wash it in injecting the flush fluid into the culture dish through the washing suction pump, still be provided with the flowing back suction pump simultaneously, get rid of the waste liquid in the culture dish through the flowing back suction pump to realize washing, the flowing back of culture dish, effectively save the experimental time, improve the experimental efficiency.

Drawings

FIG. 1 is a schematic view of the overall structure of the present invention;

fig. 2 is a schematic view showing a structure of a portion a in fig. 1.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings.

Referring to fig. 1, the U-shaped tube rapid drug delivery system comprises a U-shaped tube 1, a drug delivery device 2, a tube clamping device 3 and a negative pressure device 4.

The administration device 2 comprises a plurality of administration tubes, in the embodiment, four groups of administration tubes 21, 22, 23 and 24 are preferably adopted, and a plurality of infusion tubes 20 are respectively connected between the administration tubes 21, 22, 23 and 24 and the U-shaped tube 1, wherein two groups of administration tubes in 4 groups in the embodiment are used for containing medicines, and the other two groups are used for containing cleaning liquid, so that administration and cleaning of the U-shaped tube are facilitated.

The invention also comprises a base 101, an upright rod 102 and a vertical plate 103, wherein the upright rod 102 is fixedly arranged on the base 101, the vertical plate 103 is fixedly inserted at the upper part of the upright rod 102, a pair of flat plates 104 and 105 is arranged at the upper part and the lower part of the front side surface of the vertical plate 103, and a plurality of jacks matched with the administration tubes 21, 22, 23 and 24 are coaxially arranged between the flat plates 104 and 105, thereby facilitating the administration tubes to be hung on the vertical plate.

The tube clamping device 3 comprises a tube clamping box 31 and a plurality of tube clamping valves 32, the tube clamping box 31 is fixedly arranged in the middle of the vertical rod 102, the tube clamping valves 32 are respectively and fixedly arranged in the tube clamping box 31, and the infusion tubes 20 between the administration tubes 21, 22, 23 and 24 and the U-shaped tube 1 all penetrate through the tube clamping valves 32, so that the tube clamping valves 32 respectively control the conduction or the closing of the infusion tubes 20.

Referring to fig. 1-2, the present embodiment further includes a waste liquid bottle 5 and a washing bottle 6, wherein the waste liquid bottle 5 is used for storing waste liquid in the culture dish 7, and the washing bottle 6 is used for storing washing liquid for washing the culture dish 7.

The negative pressure device 4 includes a negative pressure pump 41 for drug administration, a suction irrigation pump 42, a suction drainage pump 43, and a mounting box 44, and the negative pressure pump 41 for drug administration, the suction irrigation pump 42, and the suction drainage pump 43 are fixedly mounted in the mounting box 44.

A first lead-in pipe 411 is connected between the air inlet end of the administration negative pressure pump 41 and the outlet end of the U-shaped conduit 1, a first lead-out pipe 412 is connected between the waste liquid bottle 5 and the air outlet end of the administration negative pressure pump 41, the curved bottom surface of the U-shaped conduit 1 is provided with a liquid outlet hole 11, the inlet end of the U-shaped conduit 1 is fixedly provided with a conduit 12, the liquid conduit 20 is inserted into the conduit 12, the outlet end of the U-shaped conduit 1 is provided with a negative pressure valve, the medicine of the administration conduit is enabled to enter the U-shaped conduit through the liquid conduit 20 under the action of the administration negative pressure pump 41 by opening the negative pressure valve and a corresponding pinch valve of the administration conduit, when the negative pressure valve is closed, the medicine in the U-shaped conduit is ejected into the culture dish 7 from the liquid outlet hole, after the administration of the U-shaped conduit is finished, the negative pressure valve and the pinch valve of the administration conduit correspondingly stored with the cleaning liquid are opened, the cleaning liquid in the administration conduit is enabled to enter the U-shaped conduit 1 through the liquid conduit 20 under the action of the administration negative pressure pump 41, the interior of the bottle is cleaned and discharged into the waste liquid bottle 6 through the first introduction tube 411 and the first discharge tube 412, thereby completing cleaning of the administration tube.

A second guide pipe 421 is connected between the air outlet end of the washing suction pump 42 and the culture dish 7, a second lead-in pipe 422 is connected between the washing bottle 6 and the air inlet end of the washing suction pump 42, and when the culture dish 7 needs to be cleaned, the washing liquid in the washing bottle 6 is injected into the culture dish 7 through the second lead-in pipe 422 and the second guide pipe 421 under the action of the washing suction pump 42, so that the inside of the culture dish 7 is washed.

A third lead-in pipe 431 is connected between the air inlet end of the liquid discharge suction pump 43 and the culture dish 7, a third lead-out pipe 432 is connected between the waste liquid bottle 5 and the air outlet end of the liquid discharge suction pump 43, and when the waste liquid in the culture dish 7 is higher than the third lead-in pipe 431, the waste liquid in the culture dish 7 is discharged into the waste liquid bottle 5 through the third lead-in pipe 431 and the third lead-out pipe 432 under the action of the liquid discharge suction pump 43, so that the waste liquid in the culture dish is discharged.

The present embodiment further includes a control module, the control module is electrically connected to the pinch valve 20, the administration negative pressure pump 41, the irrigation suction pump 42, and the drainage suction pump 43, and the control module has a plurality of buttons, and the plurality of buttons are electrically connected to the control module, in the present embodiment, preferably, five groups of buttons are adopted to control the work of the pinch valve 32, the administration negative pressure pump 41, the irrigation suction pump 42, and the drainage suction pump 43.

Referring to fig. 1-2, in particular, the invention also provides a control method of the U-shaped tube rapid drug delivery system, which comprises the following steps:

step one, respectively inputting the medicine and the flushing fluid into corresponding administration tubes 21, 22, 23 and 24 to finish preparation work;

step two, pressing the button No. 1, the control module opens the pinch valve 32 corresponding to the drug delivery tube No. 1 21 and the drug delivery negative pressure pump 41, so that the drug in the drug delivery tube No. 1 21 is fed into the U-shaped tube 1 through the infusion tube 20 under the action of the drug delivery negative pressure pump 41;

step three, closing a negative pressure valve on the U-shaped pipe 1 to enable the medicine in the U-shaped pipe 1 to be sprayed into the culture dish 7 from the liquid outlet hole 11;

step four, after the dosing is finished, pressing the button No. 2, the control module opens the pinch valve 32 corresponding to the dosing tube No. 2 22, and simultaneously opens the negative pressure valve on the U-shaped tube 1, so that the cleaning liquid in the dosing tube No. 2 22 enters the U-shaped tube 1 through the infusion tube 20 under the action of the dosing negative pressure pump 41, the cleaning liquid in the dosing tube No. 2 21 cleans the inside of the U-shaped tube 1, and is discharged into the waste liquid bottle 5 through the first lead-in tube 411 and the second lead-out tube 412;

and step five, pressing a No. 5 button, controlling the administration negative pressure pump 41 to stop working by the control module, starting the flushing suction pump 42 and the liquid drainage suction pump 43, flushing the culture dish 7 by the flushing liquid in the flushing bottle 6 through the second guide pipe 421 under the action of the flushing suction pump 42, and discharging the waste liquid in the culture dish 7 into the waste liquid bottle 5 through the third guide pipe 432 under the action of the liquid drainage suction pump 43 when the waste liquid in the culture dish 7 is higher than the third guide pipe 431 of the liquid drainage suction pump 43.

Wherein the time for flushing the U-shaped pipe in the fourth step is not less than 10 seconds.

In this embodiment, No. 3 administers the pipe 23 and stores the medicine of the different composition with No. 1 administers the pipe, No. 4 administers the pipe 24 and stores the washing liquid, its working process is the same with the above-mentioned working process, after the U type pipe washs, make No. 3 administers pipe 23 and doses to U type pipe 1 by No. 3 button messenger control module, after the administration finishes, make No. 4 administers pipe 24 and washs U type pipe 1 by No. 4 button messenger control module, make the quick of the medicine of different compositions dose, and guarantee that the medicine of this experiment does not mix with the residual medicine of the last experiment.

It should be understood that the above-mentioned embodiments are merely illustrative of the technical concept and features of the present invention, and are not intended to limit the scope of the present invention, which is defined by the following claims.