阅读说明：本技术 一种医用止血多糖敷芯 (Medical hemostatic polysaccharide applying core ) 是由 倪凯 于 2021-10-22 设计创作，主要内容包括：本发明涉及一种医用止血多糖敷芯,包括基底层、敷芯层、粘贴层、油光面脱纸层；所述敷芯层包括层叠复合在一起的第一敷料层、第二敷料层和第三敷料层；基底层中央设置有环形凹槽,第一敷料层设置于环形凹槽内；第一敷料层中间部位设置有方型凹槽,第二敷料层设置于方型凹槽内,第二敷料层上设置有多个孔洞,各孔洞内均填充有第三敷料层；粘贴层设置于基底层边沿与凹槽之间,油光面脱纸层通过粘贴层粘合在基底层的面上,并覆盖住敷芯层；第一辅料层为壳聚糖纤维膜层,由壳聚糖和甘油以重量份比为10:2电纺而成。本发明解决了现有的伤口敷料透气性不好、吸收分泌物的能力不强,进而降低了伤口愈合效率的问题。(The invention relates to a medical hemostatic polysaccharide dressing core, which comprises a substrate layer, a dressing layer, an adhesive layer and a glossy surface paper removing layer; the dressing layer comprises a first dressing layer, a second dressing layer and a third dressing layer which are laminated and compounded together; an annular groove is formed in the center of the substrate layer, and the first dressing layer is arranged in the annular groove; a square groove is arranged in the middle of the first dressing layer, the second dressing layer is arranged in the square groove, a plurality of holes are formed in the second dressing layer, and a third dressing layer is filled in each hole; the oil-polished surface paper removing layer is adhered to the surface of the substrate layer through the adhesive layer and covers the compress core layer; the first auxiliary material layer is a chitosan fiber film layer and is formed by electrospinning chitosan and glycerol according to the weight part ratio of 10: 2. The invention solves the problems that the existing wound dressing has poor air permeability and weak secretion absorption capability, thereby reducing the wound healing efficiency.)

1. A medical hemostatic polysaccharide dressing core is characterized by comprising a substrate layer, a dressing core layer, a sticking layer and a glossy surface paper removing layer; the dressing layer comprises a first dressing layer, a second dressing layer and a third dressing layer which are laminated and compounded together; an annular groove is formed in the center of the substrate layer, and the first dressing layer is arranged in the annular groove; a square groove is formed in the middle of the first dressing layer, the second dressing layer is arranged in the square groove, a plurality of holes are formed in the second dressing layer, and the third dressing layer is filled in each hole; the adhesive layer is arranged between the edge of the substrate layer and the groove, and the glossy surface paper release layer is adhered to the surface of the substrate layer through the adhesive layer and covers the compress core layer; the first auxiliary material layer is a chitosan fiber film layer and is formed by electrospinning chitosan and glycerol according to the weight part ratio of 10: 2; the second dressing layer is a hyaluronic acid fiber membrane layer and is composed of hyaluronic acid fibers, and the hyaluronic acid fiber membrane layer is prepared by an electrostatic spinning technology; the third dressing layer is an alginate dressing layer.

2. The medical dressing of claim 1, wherein the antibacterial and antiseptic nanofiber dressing comprises: the alginate dressing layer is prepared by soaking alginate fiber non-woven fabrics in a functional soaking solution; the functional soak solution is prepared from the following raw materials in parts by weight: 8-11 parts of carboxymethyl chitosan, 1-3 parts of hyaluronic acid-like chitosan, 0.1-0.15 part of antibacterial agent, 0.5-6 parts of sodium carboxymethyl cellulose, 0.3-0.5 part of epidermal cell growth factor, 0.3-0.5 part of collagen and 52-72 parts of water.

3. The medical dressing of claim 2, wherein the antibacterial and antiseptic nanofiber dressing comprises: the antibacterial agent is antibacterial peptide; the mass part ratio of the alginate fiber non-woven fabric to the functional soak solution is 1:12-1: 32.

4. The medical dressing of claim 2, wherein the antibacterial and antiseptic nanofiber dressing comprises: the preparation method of the alginate dressing layer comprises the following operation steps: (1) adding carboxymethyl chitosan, chitosan of chitosan hyaluronic acid, antibacterial agent, sodium carboxymethylcellulose, epidermal growth factor and collagen into water, and mixing to obtain functional soaking solution; (2) and (2) soaking the alginate fiber non-woven fabric into the soaking solution prepared in the step (1) for 7 hours, taking out the alginate fiber non-woven fabric, freeze-drying and irradiating to obtain the alginate dressing layer.

5. The medical dressing of claim 1, wherein the antibacterial and antiseptic nanofiber dressing comprises: the hyaluronic acid fiber is obtained by the following steps: adding surfactant cocoamido propyl betaine, glycerol and hyaluronic acid into solvent water, stirring and mixing for 1 hour to uniformly mix, and electrospinning to obtain hyaluronic acid fiber.

6. The medical dressing of claim 5, wherein the antibacterial and antiseptic nanofiber dressing comprises: the weight ratio of the hyaluronic acid to the water to the glycerin to the cocamidopropyl betaine is 30:60:20: 1.

7. The medical dressing of claim 1, wherein the antibacterial and antiseptic nanofiber dressing comprises: the adhesive layer is a medical pressure-sensitive adhesive layer with low allergenicity; the oil-glazed paper supporting layer is glassine silicone oil paper.

8. The medical dressing of claim 1, wherein the antibacterial and antiseptic nanofiber dressing comprises: the base layer is one of a waterproof breathable film, a spun-bonded non-woven fabric and a spunlace non-woven fabric.

9. The medical dressing of claim 1, wherein the antibacterial and antiseptic nanofiber dressing comprises: the basal layer is rectangular, butterfly-shaped, circular, oval, triangular or special-shaped.

10. The medical dressing of claim 1, wherein the antibacterial and antiseptic nanofiber dressing comprises: the edge of the oil polished surface paper removing layer is provided with an opening for tearing.

Technical Field

The invention relates to the technical field of medical dressing materials, in particular to a medical hemostatic polysaccharide dressing core.

Background

The skin is an important organ of the human body and consists of epidermis, dermis and subcutaneous tissue parts, and the basic functions of the skin have five aspects: protection function, body temperature regulation function, feeling function, perspiration function and absorption function. And has important physical, chemical and biological barrier functions. As a first barrier of a human body, the skin is extremely vulnerable in daily life, and acute skin trauma can be caused by improper use of cutters, falling injuries, traffic accidents, fighting and the like; skin ulcers, especially chronic skin ulcers, as a common disease, are long in course, difficult to cure and easy to recur, seriously affecting the life and working quality of patients. Various damages caused after skin trauma such as increased metabolism, decreased body temperature, excessive loss of moisture, blood and protein, and disturbance of endocrine and immune systems are associated with the loss of skin barrier function. If the wound surface is not properly protected, the wound surface is easy to be infected with bacteria, deep transformation can be deepened once the wound surface cannot be effectively controlled by infection, and sepsis can be caused subsequently when the infected flora enters the body.

Chitosan has good biocompatibility and antiviral property, refined chitosan fine powder can obviously promote wound healing, a film made of chitosan or non-woven fabrics made of chitosan and other fibers such as cotton, cellulose and the like can be used as a good wound dressing for wound surface protection, various medical dressings made of chitosan fibers are used for clinical application of scald, scratch, skin laceration and the like, the curative effect is obvious, the chitosan dressing mainly shows no reaction on the wound, has the effects of sterilizing, diminishing inflammation and promoting tissue growth, the curative effect period is shortened, the healed wound surface is similar to normal tissue, no scar is formed, the existing wound dressing has poor air permeability and weak capability of absorbing secretion, and further the wound healing efficiency is reduced.

In view of the above problems, it is desirable to provide a medical hemostatic polysaccharide dressing core.

Disclosure of Invention

The invention aims to provide a medical hemostatic polysaccharide dressing core which has the advantage of higher absorptivity and solves the problems that the existing wound dressing is poor in air permeability and weak in secretion absorption capacity, and further the wound healing efficiency is reduced.

In order to achieve the aim of the invention, the medical hemostatic polysaccharide dressing core comprises a substrate layer, a dressing layer, a sticking layer and a glossy surface paper removing layer; the dressing layer comprises a first dressing layer, a second dressing layer and a third dressing layer which are laminated and compounded together; an annular groove is formed in the center of the substrate layer, and the first dressing layer is arranged in the annular groove; a square groove is formed in the middle of the first dressing layer, the second dressing layer is arranged in the square groove, a plurality of holes are formed in the second dressing layer, and the third dressing layer is filled in each hole; the adhesive layer is arranged between the edge of the substrate layer and the groove, and the glossy surface paper release layer is adhered to the surface of the substrate layer through the adhesive layer and covers the compress core layer; the first auxiliary material layer is a chitosan fiber film layer and is formed by electrospinning chitosan and glycerol according to the weight part ratio of 10: 2; the second dressing layer is a hyaluronic acid fiber membrane layer and is composed of hyaluronic acid fibers, and the hyaluronic acid fiber membrane layer is prepared by an electrostatic spinning technology; the third dressing layer is an alginate dressing layer.

Preferably, the alginate dressing layer is prepared by soaking alginate fiber non-woven fabrics in a functional soaking solution; the functional soak solution is prepared from the following raw materials in parts by weight: 8-11 parts of carboxymethyl chitosan, 1-3 parts of hyaluronic acid-like chitosan, 0.1-0.15 part of antibacterial agent, 0.5-6 parts of sodium carboxymethyl cellulose, 0.3-0.5 part of epidermal cell growth factor, 0.3-0.5 part of collagen and 52-72 parts of water.

Preferably, the antibacterial agent is an antibacterial peptide; the mass part ratio of the alginate fiber non-woven fabric to the functional soak solution is 1:12-1: 32.

Preferably, the preparation method of the alginate dressing layer comprises the following operation steps: (1) adding carboxymethyl chitosan, chitosan of chitosan hyaluronic acid, antibacterial agent, sodium carboxymethylcellulose, epidermal growth factor and collagen into water, and mixing to obtain functional soaking solution; (2) and (2) soaking the alginate fiber non-woven fabric into the soaking solution prepared in the step (1) for 7 hours, taking out the alginate fiber non-woven fabric, freeze-drying and irradiating to obtain the alginate dressing layer.

Preferably, the hyaluronic acid fiber is obtained by the following steps: adding surfactant cocoamido propyl betaine, glycerol and hyaluronic acid into solvent water, stirring and mixing for 1 hour to uniformly mix, and electrospinning to obtain hyaluronic acid fiber.

Preferably, the weight ratio of hyaluronic acid, water, glycerol, cocamidopropyl betaine is 30:60:20: 1.

Preferably, the adhesive layer is a medical pressure-sensitive adhesive layer with low sensitization; the oil-glazed paper supporting layer is glassine silicone oil paper.

Preferably, the substrate layer is one of a waterproof breathable film, a spun-bonded non-woven fabric and a spunlace non-woven fabric.

Preferably, the base layer is rectangular, butterfly, circular, oval, triangular or profiled.

Preferably, the edge of the glossy surface paper release layer is provided with an opening for tearing.

Compared with the prior art, the medical hemostatic polysaccharide dressing core has the following advantages:

(1) the wound healing promoting ointment has the advantages of being capable of accelerating wound healing, lasting in drug effect, free of toxic and side effects, capable of promoting wound healing, having a hemostatic effect, and having super-strong absorption capacity, and capable of rapidly absorbing a large amount of seepage to avoid the skin from being in a humid environment;

(2) the chitosan has the characteristics of antibiosis, antiphlogosis, hemostasis and the like; hyaluronic acid contributes to cell repair, keeps skin moist, heals wounds faster, has higher quality of tissue repair, also contributes to cell migration and cell proliferation, thereby promoting tissue growth and angiogenesis, and can regulate phagocytosis by regulating macrophage movement; the fibrous component of alginate fibres is from seaweed, absorbing large amounts of fluid and therefore are commonly used for significant exuding wounds; the application range is wide, and the dressing is suitable for wet wound surfaces with more exudates and dry wound surfaces needing dressing to moisturize the wound surfaces;

(3) the antibacterial and disinfectant nanofiber medical dressing combines multiple layers of auxiliary materials with different effects together to form a formed product which can be directly used without adding medicines. When the wound dressing is used, the glossy surface paper removing layer can be directly torn off and is pasted on a wound through the pasting layer, and the chitosan fiber film layer, the hyaluronic acid fiber film layer and the alginate dressing layer are mutually matched to efficiently perform antibacterial disinfection, so that the wound healing is promoted, the use is convenient, and the antibacterial and antivirus effects are obvious.

Drawings

FIG. 1 is a schematic cross-sectional view of a hemostatic polysaccharide core according to this embodiment;

wherein, 1-a substrate layer; 2-a first dressing layer; 3-a second dressing layer; 4-a third dressing layer; 5-a sticking layer; 6-oil polished surface paper removing layer.

Detailed Description

The invention is further described below with reference to the following figures and specific examples.

Example 1

The preparation operation steps of the alginate dressing layer are as follows: (1) adding 8 parts of carboxymethyl chitosan, 1 part of shell hyaluronic acid chitosan, 0.1 part of antibacterial peptide, 0.5 part of sodium carboxymethyl cellulose, 0.3 part of epidermal cell growth factor and 0.3 part of collagen into 52 parts of water, and uniformly mixing to obtain a functional soaking solution; (2) and (2) soaking 6 parts of alginate fiber non-woven fabric into the soaking solution prepared in the step (1) for 6 hours, taking out the alginate fiber non-woven fabric, freeze-drying and irradiating to obtain the alginate dressing layer.

A medical hemostatic polysaccharide dressing core comprises a laminated composite waterproof breathable film, a chitosan fiber film layer, a hyaluronic acid fiber film layer, an alginate dressing layer, an adhesive layer and an oil-polished surface paper release layer; the center of the waterproof breathable film is provided with a structure with an annular groove, and the chitosan fiber film layer is arranged in the annular groove; a square groove is formed in the middle of the chitosan fiber film layer, the hyaluronic acid fiber film layer is arranged in the square groove, a hole is formed in the hyaluronic acid fiber film layer, and an alginate dressing layer is filled in the hole; the pasting layer is arranged between the edge of the waterproof breathable film and the groove, and the oil-polished surface paper removing layer is adhered to the surface of the waterproof breathable film through the pasting layer and covers the chitosan fiber film layer, the hyaluronic acid fiber film layer and the alginate dressing layer.

Example 2: the preparation operation steps of the alginate dressing layer are as follows: (1) adding 10 parts of carboxymethyl chitosan, 2 parts of shell hyaluronic acid chitosan, 0.13 part of antibacterial peptide, 3 parts of sodium carboxymethyl cellulose, 0.4 part of epidermal cell growth factor and 0.3 part of collagen into 60 parts of water, and uniformly mixing to obtain a functional soaking solution; (2) and (2) soaking 4 parts of alginate fiber non-woven fabric into the soaking solution prepared in the step (1) for 6 hours, taking out the alginate fiber non-woven fabric, freeze-drying and irradiating to obtain the alginate dressing layer.

A medical hemostatic polysaccharide dressing core comprises a laminated composite waterproof breathable film, a chitosan fiber film layer, a hyaluronic acid fiber film layer, an alginate dressing layer, an adhesive layer and an oil-polished surface paper release layer; the center of the waterproof breathable film is provided with a structure with an annular groove, and the chitosan fiber film layer is arranged in the annular groove; a square groove is formed in the middle of the chitosan fiber film layer, the hyaluronic acid fiber film layer is arranged in the square groove, a hole is formed in the hyaluronic acid fiber film layer, and an alginate dressing layer is filled in the hole; the pasting layer is arranged between the edge of the waterproof breathable film and the groove, and the oil-polished surface paper removing layer is adhered to the surface of the waterproof breathable film through the pasting layer and covers the chitosan fiber film layer, the hyaluronic acid fiber film layer and the alginate dressing layer.

Example 3: the preparation operation steps of the alginate dressing layer are as follows: (1) adding 11 parts of carboxymethyl chitosan, 3 parts of shell hyaluronic acid chitosan, 0.15 part of antibacterial peptide, 6 parts of sodium carboxymethyl cellulose, 0.5 part of epidermal cell growth factor and 0.5 part of collagen into 72 parts of water, and uniformly mixing to obtain a functional soaking solution; (2) and (2) soaking 3 parts of alginate fiber non-woven fabric into the soaking solution prepared in the step (1) for 6 hours, taking out the alginate fiber non-woven fabric, freeze-drying and irradiating to obtain the alginate dressing layer.

A medical hemostatic polysaccharide dressing core comprises a laminated composite waterproof breathable film, a chitosan fiber film layer, a hyaluronic acid fiber film layer, an alginate dressing layer, an adhesive layer and an oil-polished surface paper release layer; the center of the waterproof breathable film is provided with a structure with an annular groove, and the chitosan fiber film layer is arranged in the annular groove; a square groove is formed in the middle of the chitosan fiber film layer, the hyaluronic acid fiber film layer is arranged in the square groove, a hole is formed in the hyaluronic acid fiber film layer, and an alginate dressing layer is filled in the hole; the pasting layer is arranged between the edge of the waterproof breathable film and the groove, and the oil-polished surface paper removing layer is adhered to the surface of the waterproof breathable film through the pasting layer and covers the chitosan fiber film layer, the hyaluronic acid fiber film layer and the alginate dressing layer.

The core dressing performance test is as follows: (1) and (3) moisture absorption detection: the dressing prepared in the example of 5cm × 5cm was soaked in deionized water for 10min, and the water absorption of the dressing was obtained by measuring the weight of the dressing before and after soaking. (2) Antibacterial property: the determination of the antibacterial property under the antibacterial moist condition was carried out according to YY/T0471.5 contact wound dressing test method part 5. The test data are as follows:

as can be seen from the above table, the water absorbability and the antibacterial property of examples 1 to 3 of the present invention are excellent.

Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.