阅读说明：本技术 一种治疗不孕不育的中药组方 (Traditional Chinese medicine formula for treating infertility ) 是由 雷朝德 雷新宇 于 2021-11-04 设计创作，主要内容包括：一种治疗不孕不育的中药组方,其组方及各组方的重量份数如下：子母鸡肉200-300份；胡颓子根50-65份；山胡椒根38-48份；大乌泡根35-45份；茜草20-30份；土牛膝30-40份；益母草25-40份；女贞子30-40份；紫苏8-12份；食盐4-7份。本方用于不孕不育症的治疗,对女方具有温补肾阳、调理经络、洁净子宫、促进卵泡生成的功效,对男方具有温补肾阳、增强健康精子的活力、增加健康精子数量的功效,具有很好的治疗作用和良好的市场前景,解决了不孕不育症给患者带来的各种痛苦。(A traditional Chinese medicine formula for treating infertility comprises the following components in parts by weight: 200 portions and 300 portions of primary and secondary chicken; 50-65 parts of elaeagnus pungens root; 38-48 parts of mountain pepper root; 35-45 parts of radix aconiti kusnezoffii; 20-30 parts of madder; 30-40 parts of achyranthes aspera; 25-40 parts of motherwort; 30-40 parts of glossy privet fruit; 8-12 parts of purple perilla; 4-7 parts of table salt. The traditional Chinese medicine composition is used for treating infertility, has the effects of warming and invigorating kidney yang, conditioning channels and collaterals, cleaning uterus and promoting follicular formation for female, has the effects of warming and invigorating kidney yang, enhancing the vitality of healthy sperms and increasing the number of healthy sperms for male, has good treatment effect and good market prospect, and solves various pains caused by infertility to patients.)

1. The traditional Chinese medicine formula for treating infertility is characterized by comprising the following components in parts by weight: 200 portions and 300 portions of primary and secondary chicken; 50-65 parts of elaeagnus pungens root; 38-48 parts of mountain pepper root; 35-45 parts of radix aconiti kusnezoffii; 20-30 parts of madder; 30-40 parts of achyranthes aspera; 25-40 parts of motherwort; 30-40 parts of glossy privet fruit; 8-12 parts of purple perilla; 4-7 parts of table salt.

2. The prescription of a Chinese medicine for treating infertility according to claim 1, wherein the primary and secondary chicken are hens which have not laid eggs, and the primary and secondary chicken are used as guiding drugs for harmonizing the efficacy of other Chinese medicines.

3. The traditional Chinese medicine formula for treating infertility according to claim 2, which is characterized by comprising the following components in parts by weight: 300 parts of mother-son chicken; 65 parts of elaeagnus pungens roots; 38 parts of mountain pepper root; 35 parts of radix aconiti kusnezoffii; 20 parts of madder; 30 parts of achyranthes aspera; 25 parts of motherwort; 30 parts of glossy privet fruit; 8 parts of purple perilla; 4 parts of table salt.

4. The traditional Chinese medicine formula for treating infertility according to claim 2, which is characterized by comprising the following components in parts by weight: 200 parts of mother-son chicken; 50 parts of elaeagnus pungens root; 48 parts of mountain pepper roots; 45 parts of radix aconiti kusnezoffii; 30 parts of madder; 40 parts of achyranthes aspera; 40 parts of motherwort; 40 parts of glossy privet fruit; 12 parts of purple perilla; and 7 parts of table salt.

5. The traditional Chinese medicine formula for treating infertility according to claim 2, which is characterized by comprising the following components in parts by weight: 250 parts of mother-son chicken; 57.5 parts of elaeagnus pungens roots; 43 parts of mountain pepper root; 40 parts of radix aconiti kusnezoffii; 25 parts of madder; 35 parts of achyranthes aspera; 32.5 parts of motherwort; 35 parts of glossy privet fruit; 10 parts of purple perilla; 5.5 parts of table salt.

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine formula for treating infertility.

Background

Traditional Chinese medicine holds that kidney is the congenital foundation, stores essence, controls reproduction and is one of the main organs of human body activity, but kidney qi and kidney essence are exhausted, and all organs are affected, especially in the aspect of fertility. With the modern life pressure and the change of dietary habits, more and more patients with infertility are seen, women show irregular menstruation, amenorrhea, deficient cold of uterus cells, tumors and the like, and men show sexual dysfunction including symptoms of impotence, premature ejaculation, oligospermia, weak sperm and the like, which are closely related to kidney essence.

At present, the western medicine method for treating infertility mainly comprises two methods of artificial tube infants and estrogen treatment. However, both of the two methods have great disadvantages, the artificial test tube infant method has great harm to human bodies, low success rate and high cost, and causes great economic pressure on patients, and although the estrogen treatment has low economic cost, endocrine dysfunction and disorder can be caused to a certain extent, so that secondary infertility is easily caused.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine formula for treating infertility. The formula has the effects of warming and invigorating kidney yang, conditioning channels and collaterals, cleaning uterus and promoting follicular formation for female, has the effects of warming and invigorating kidney yang, enhancing the vitality of healthy sperms and increasing the number of healthy sperms for male, has good treatment effect and good market prospect, and solves various pains caused to patients by infertility.

The technical scheme of the invention is as follows: a traditional Chinese medicine formula for treating infertility comprises the following components in parts by weight: 200 portions and 300 portions of primary and secondary chicken; 50-65 parts of elaeagnus pungens root; 38-48 parts of mountain pepper root; 35-45 parts of radix aconiti kusnezoffii; 20-30 parts of madder; 30-40 parts of achyranthes aspera; 25-40 parts of motherwort; 30-40 parts of glossy privet fruit; 8-12 parts of purple perilla; 4-7 parts of table salt.

The further technical scheme of the invention is as follows: the primary and secondary chicken are hens which have not laid eggs, and the primary and secondary chicken are used as guiding drugs for regulating the drug effects of other traditional Chinese medicines.

The invention further adopts the technical scheme that: the formula comprises the following components in parts by weight: 300 parts of mother-son chicken; 65 parts of elaeagnus pungens roots; 38 parts of mountain pepper root; 35 parts of radix aconiti kusnezoffii; 20 parts of madder; 30 parts of achyranthes aspera; 25 parts of motherwort; 30 parts of glossy privet fruit; 8 parts of purple perilla; 4 parts of table salt.

The invention further adopts the technical scheme that: the formula comprises the following components in parts by weight: 200 parts of mother-son chicken; 50 parts of elaeagnus pungens root; 48 parts of mountain pepper roots; 45 parts of radix aconiti kusnezoffii; 30 parts of madder; 40 parts of achyranthes aspera; 40 parts of motherwort; 40 parts of glossy privet fruit; 12 parts of purple perilla; and 7 parts of table salt.

The invention further adopts the technical scheme that: the formula comprises the following components in parts by weight: 250 parts of mother-son chicken; 57.5 parts of elaeagnus pungens roots; 43 parts of mountain pepper root; 40 parts of radix aconiti kusnezoffii; 25 parts of madder; 35 parts of achyranthes aspera; 32.5 parts of motherwort; 35 parts of glossy privet fruit; 10 parts of purple perilla; 5.5 parts of table salt.

Compared with the prior art, the invention has the following advantages:

1. the traditional Chinese medicine composition is used for treating infertility, has the effects of warming and invigorating kidney yang, conditioning channels and collaterals, cleaning uterus and promoting follicular formation for female, has the effects of warming and invigorating kidney yang, enhancing the vitality of healthy sperms and increasing the number of healthy sperms for male, has good treatment effect and good market prospect, and solves various pains caused by infertility to patients.

2. Before the male and female use the prescription, the required examination is relatively less, the male only needs to carry out semen test, and the female only needs to carry out hysteroscopy and/or uterus radiography, thus the prescription can be used as the basis for medication. Compared with the western medicine for treating infertility, the method greatly reduces the examination amount and the money cost.

Detailed Description

Example 1:

a traditional Chinese medicine formula for treating infertility comprises the following components in parts by weight: 250 parts of mother-son chicken; 57.5 parts of elaeagnus pungens roots; 43 parts of mountain pepper root; 40 parts of radix aconiti kusnezoffii; 25 parts of madder; 35 parts of achyranthes aspera; 32.5 parts of motherwort; 35 parts of glossy privet fruit; 10 parts of purple perilla; 5.5 parts of table salt.

Wherein, the mother-son chicken and the elaeagnus pungens root are monarch drugs; mountain pepper root and radix linderae are used as ministerial drugs; radix Rubiae, radix Achyranthis, herba Leonuri, fructus Ligustri Lucidi and Perillae herba as adjuvant drugs; salt is used as a messenger drug;

in the traditional Chinese medicine formula, the pharmacological effects of the components are as follows:

mother-son chicken meat: the primary and secondary chicken are hens which have not laid eggs, and the primary and secondary chicken are used as guiding drugs for regulating the drug effects of other traditional Chinese medicines. The chicken meat of mother and son mainly plays the role of warming and tonifying yang qi.

Thorny elaeagnus root: the terms are "half spring", "sweet club head", "Qingming", "milk" and "pansang fruit". The form is characterized by evergreen shrubs with thorns, the height of 1-4 meters and the growth under the mountain slope or in the shrubs on the forest side. The roots are woody, yellow-white, the stems are provided with thorns, and the small branches are densely covered with brown scales. Leaves are intergrown, leathery, with short stems, oval or oblong, pointed or blunt tips, wedge-shaped or rounded stems, and wavy curls all around. The leaf surface is green and glossy, the back surface of the leaf is silvery gray, and the leaf is mixed with brown spots. In autumn and winter, 1-4 flowers are bloomed at the axilla, and the flowers are silvery white, drooping and fragrant. Berries are oblong, initially brown, blotchy, reddish brown at maturity and sour and sweet in taste. Most of the properties of the thorny elaeagnus fruit are concentrated at the root, so the root is used as a medicine to mainly enhance the cell division function of the human body, promote the spermatogenesis of male prescriptions and promote the follicle generation of female prescriptions.

Mountain pepper root: the alias is "chaste tree" and "cowhells tree". Morphological features are deciduous shrubs or small trees, up to 8 meters. The root of the tree is thick, the outer skin is grey white or dark brown, the cross section is fleshy, and fishy smell is generated after the tree is dried in the sun. The bark is smooth, grey or off-white. The outer scales of the winter bud are red. The tender branches are initially covered by brown short hairs and then gradually fall off. Leaf intergrowth or nearly-intergrowth; the petiole is about 2 mm long and has fine hair. The leaves are wide and elliptical to narrow and inverted oval, 4-9 cm long and 2-4 cm wide, the tip is short and sharp, the base is wide and wedge-shaped, the whole edge is dark green, fine hair exists only between the veins, the lower part is pink green, dense gray soft hair exists, and the veins are pinnate. 5-6 strips per side. Parthenocarpy, heterogynic plant; the umbelliform inflorescence, total pedicel is short or not obvious, 3-8 small flowers are clustered in the leaf axils of the first-year branches. The pedicel is 6-8 mm long and has short and soft hair. The flower quilt is 6 pieces, yellow, the male flower has stamen 9, arrange into 3 rounds, the anther 2 rooms, the petal splits inside; the female flowers have small degenerated stamens, oval ovaries and 1 chamber, and the length of the ovaries is about 1.5 mm; the length of the flower column is about 0.3 mm, and the column head is disc-shaped. The drupes are spherical, the diameter is about 7 mm, and the drupes have fragrance; the stem length is 1-1.5 cm, the flowering phase is 3-4 months, and the fruit maturity phase is 7-9 months. The lindera glauca root has the main function of dispersing and promoting the flow of channel qi and blood, and the pharmacological action of the lindera glauca root is complementary to the pharmacological action of the lindera glauca root, so that the drug effect of the lindera glauca root is enhanced.

Root of big dark-red-rooted salvia: the other names are yellow blister, inverted root, non-thorn black blister, sugar blister, rubus bifidus leaf and red clover-root. The form is characterized by shrubs, 2-3 m in height and growing in hillside shrubs. The stem is covered with dark yellow green felt hair without thorns. The single leaf grows alternately, the petiole is densely covered with felt hair, the leaf is nearly round, five-fold and shallow-split, the tip lobe is blunt, three-fold and shallow-split, the outer lobe is ear-shaped, the tooth margin is irregular, the upper surface is provided with short hair and small rough points, and the lower surface is grey white. The panicle or the raceme is terminal or axillary and is closely covered with yellow villus. The polymerized fruit is spherical, and most red berry-shaped drupes grow on the polymerized fruit. The radix Rubi Corchorifolii Immaturus mainly has the effect of promoting the flow of meridian qi downward, and is complementary to the pharmacological action of radix Linderae, so as to enhance the drug effect of radix Linderae.

Madder root: the terms "Xiaohuo", "xueyingcheng", "hongxiao", "Disappan wood" and "honggen grass" are also used herein. The shape is characterized by perennial sprawl herbs which grow in shrub clusters on the field side, roadside and low hillside. Slender root, golden yellow or orange-red. The stem is square, has four edges and is used for dredging fine barbs. 4 leaves are grown in a wheel, and have long handles. The egg-shaped or egg-shaped is needle-shaped, the tip is gradually sharp, the base part is heart-shaped, and the whole edge, the petiole, the leaf edge and the reverse side of the leaf are provided with fine thorns. In autumn, the axilla of the tip leaves are opened with faint yellow flowers which are arranged into a conical cymbidium. Fleshy berries with a nodular texture, which are dark at maturity. Rubia cordifolia has effects of promoting blood circulation, and resolving blood viscosity, and can improve menstruation lumping phenomenon.

Achyranthes aspera: the other names are 'white achyranthes root', 'red achyranthes root', 'para-clover root' and 'red stalk grass root'. The shape is characterized by perennial herbs and the height is about 60 cm. It is born on hillside, roadside, and sunny place beside house. Thick and long root, cylindrical, yellow-white or red. The stem is square, the nodes are swollen like the knee of a cow, and the upper nodes branch oppositely. Leaf-in-leaf, oval, wedge-shaped base, long tip, two faces of the leaf and petiole part are all villi. In summer, light green florets and spike inflorescences are formed at the tops of branches and leaves and axilla. The achyranthes aspera has the effect of relieving swelling from the inside of a body, has good swelling relieving and dredging effects on fallopian tube blockage caused by inflammation, and has good swelling relieving effect on uterine swelling of unknown reasons.

Motherwort: the names of the Chinese characters are , motherwort fruit, motherwort herb, jiuhuang building and mica grass. The shape is characterized in that the stem is upright, the height is usually 30-120 cm, the stem is blunt quadrangular, the stem is slightly grooved, the stem has inverted rough hair, the stem is particularly dense on nodes and edges, the base is sometimes nearly hairless, the stem has multiple branches, or fertile small branches are only arranged above the middle part of the stem. The impeller profile is greatly changed, the impeller profile at the lower part of the stem is oval, the base part is wide and wedge-shaped, the palm is 3-shaped, the lobe is in a shape from long round diamond to oval, the length is usually 2.5-6 cm, the width is 1.5-4 cm, the lobe is split again on the lobe, the upper part is green, rough hair exists, the vein sinks slightly, the lower part is light green, the upper part is sparse and soft, the gland point is located, the vein is protruded, the petiole is slender, the length is 2-3 cm, the upper part is slightly finned due to the downward extension of the base of the lobe, the abdominal surface is provided with a groove, the back surface is circular, and the leaf is rough; the profile of the impeller in the middle of the stem is rhombic and small, and the impeller is usually split into 3 or even a plurality of long round linear splits, the base part is in a narrow wedge shape, and the length of the blade stem is 0.5-2 cm. The bracts on the uppermost part of the inflorescence are nearly sessile, are in a shape of a thread or a thread, are in a needle shape, have the length of 3-12 cm and the width of 2-8 mm, and are full of edges or have rare teeth. The cymbidium floribundum axillary is 8-15 flowers, the outline is spherical, the diameter is 2-2.5 cm, and most of the cymbidium floribundum axillary is far away from the cymbidium floribundum to form a long spike-shaped inflorescence; the bract is thorn-shaped, extends upwards, the base part is slightly bent, is shorter than a calyx cylinder and is about 5 mm long, and attached micro soft hair exists; the flower stalk is not existed. Motherwort mainly has the functions of cleaning uterus (diminishing inflammation) and protecting endometrium.

Glossy privet fruit: the alias is privet fruit, Chinese ilex seed, flea, Chinese ash tree seed and catalpa seed. The form is characterized by evergreen big shrubs or small trees with more than 10 meters. The bark is gray to light gray brown, the branch is smooth and has a bark hole. The leaves are opposite, the leaf stalks are 1-2 cm long, and grooves are formed in the leaves; the leaf is leathery, is in a shape of a needle from an oval to an egg, is 5-14 cm long, 3.5-6 cm wide, gradually tapers to a sharp tip at the tip, is wide and wedge-shaped at the base, is full-edged, is dark green on the upper surface, is glossy, is light green on the lower surface, is densely covered with tiny transparent glandular spots, and has obvious main pulse. Growing the cone inflorescence at the top, wherein the growth is 10-15 cm, and the diameter is 8-17 cm; total pedicel length about 4 cm, or none; the shape of the bract is leaf-shaped, the shape of the wire is needle-shaped, the stalk is not present, the early fall is realized, and the shape of the small bract is oval-shaped and triangular; the small pedicel is extremely short or almost none; calyx is bell-shaped, about 1.5 mm long and 4 shallowly fissured; the corolla tube is about as long as the lobe, the lobe 4 is of a rectangular oval shape, the length is about 2 mm, and the corolla tube is white; stamen 2, which grows in the throat of the corolla tube, has thin filaments and extends out of the corolla; pistil 1, upper ovary, sphere, 2 chambers, columniform style, with shallow stigma 2. Berry-shaped stone fruits which are oblong and 6-12 mm long are green when young and blue-black when ripe. 1-2 seeds with oblong shape. The flowering period is 6-7 months. The fruit period is 8-12 months. The glossy privet fruit is used for nourishing kidney yang, has the effects of increasing the number of healthy sperms and repairing teratospermia on male prescriptions, and has the effect of promoting follicular growth on female prescriptions. In addition, the medicine has the efficacy of strengthening the medicinal effect of the elaeagnus pungens.

Purple perilla: labiatae, Perilla genus annual herbaceous plant. The stem is 0.3-2 m high, green or purple, blunt quadrangular, with four grooves, dense, long and soft. The leaves are wide, oval or round, 7-13 cm long, 4.5-10 cm wide, short or sharp at the tip, and 7-8 pairs of side veins, which are slightly close to the lower part and rise obliquely; the petiole is 3-5 cm long, the back and abdomen are flat, the quilt is dense and the hair is soft. The cymbidium floribundum inflorescence 2 flowers consist of a terminal and axillary general inflorescences with the length of 1.5-15 cm, thick quilts, soft hairs and deviation to one side; the bract is oval or nearly round in width, the length and the width are about 4 mm, the tip is short and sharp, and the outer skin is reddish brown, has no hair and has membranous edge; the pedicel is 1.5 mm long and is dense and soft. The calyx is bell-shaped, 10 pulses, about 3 mm long, straight and stretched, and the lower part is hairy and has yellow gland points. The front ends of the flower columns are equal to 2 shallow cracks. The front of the flower disc is expanded in finger shape. The small nuts are approximately spherical, grayish brown, about 1.5 mm in diameter, and have reticulate patterns. The flowering period is 8-11 months, and the fruit period is 8-12 months. The purple perilla has divergent drug properties, has the efficacy of dissolving leucorrhea, indirectly plays a role of cleaning uterine cavity, and has the efficacy of strengthening the drug effects of achyranthes aspera, motherwort herb and glossy privet fruit.

Salt: has effects of penetration, anti-inflammatory and flavoring, and is helpful for other Chinese medicinal materials to penetrate into kidney meridian.

Example 2:

a traditional Chinese medicine formula for treating infertility comprises the following components in parts by weight: 300 parts of mother-son chicken; 65 parts of elaeagnus pungens roots; 38 parts of mountain pepper root; 35 parts of radix aconiti kusnezoffii; 20 parts of madder; 30 parts of achyranthes aspera; 25 parts of motherwort; 30 parts of glossy privet fruit; 8 parts of purple perilla; 4 parts of table salt.

Example 3:

a traditional Chinese medicine formula for treating infertility comprises the following components in parts by weight: 200 parts of mother-son chicken; 50 parts of elaeagnus pungens root; 48 parts of mountain pepper roots; 45 parts of radix aconiti kusnezoffii; 30 parts of madder; 40 parts of achyranthes aspera; 40 parts of motherwort; 40 parts of glossy privet fruit; 12 parts of purple perilla; and 7 parts of table salt.

The practical cases for proving the curative effect of the present invention are as follows:

the first example:

the female prescription is as follows: liu Zhi, 29 years old, Hainan Hening. Bilateral blockage of fallopian tube, irregular menstruation, dark red color, white eyeball with marks, thick and white tongue coating, and delayed pulse condition. For more than 7 years, the patient never has pregnant, and in order to solve the problem of infertility, the patient has to take four times of water and take a large amount of traditional Chinese medicines and western medicines, and the effect is not achieved.

Male part: semen examination is normal and body is healthy.

Diagnosis and treatment: the blockage of the fallopian tubes at both sides is an appearance, and the excess belongs to the disease caused by imbalance of yin and yang, deficiency of qi and blood, stagnation of qi and blood stasis and serious internal dampness. The blockage of the fallopian tube is general inflammation, and the pre-adjustment before pregnancy is not needed, so the medicine is directly taken. The medicine is used as follows: 48g of mountain pepper root, 45g of big radix linderae, 30g of madder, 40g of achyranthes aspera, 65g of elaeagnus pungens root, one primary and secondary chicken and 5g of salt. This is the dose for a couple. One dose is taken every day, one dose is decocted for two times, and three doses are taken continuously. Both men and women need to take the medicine in the same period, and women need to take the medicine after the menstruation is clear. After the day 2, yellow viscous fluid is discharged from the vagina, indicating that the oviduct is unblocked. After both men and women use the three doses of the medicine, the two parties have the same room and become pregnant successfully in the current month.

The second example is as follows:

male part: ma Chi, 33 years old, Changsha. The number of healthy sperm was only 5% in seminal fluid examination.

The female prescription is as follows: lie, 30 years old, Changsha. Through the examination of radiography, the uterine orifice has mild inflammation, less menstrual flow and excessive leucorrhea.

Diagnosis and treatment: some diseases of plum are mild symptoms and can not be preset. The treatment scheme comprises the following steps: the sexual intercourse with wife is forbidden during the period of taking the pre-prepared medicine by Ma, which is beneficial to nourishing essence, qi and spirit and quickly recovering the body. The Ma Chi takes the pre-prepared medicine until the Li Chi has a menstruation and the prescription of stopping the menstruation can stop. Pre-mixing the medicines: 9g of American ginseng, 8g of rhizoma polygonati, 8g of angelica, 7g of eucommia bark, 8g of radix ophiopogonis, 7g of dried orange peel, 7g of semen cuscutae, 7g of semen plantaginis and 15g of medlar (not decocted, eaten twice without raw eating). The medicine is taken by a single person, one dose is taken every day, each dose is decocted twice, and the plum is used for menstruation continuously, and the medicine is stopped after the menstruation stops.

The first course of treatment of both men and women is as follows: 40g of mountain pepper root, 30g of radix linderae, 20g of madder, 30g of achyranthes aspera, 50g of elaeagnus pungens root, one mother-son chicken and 6g of salt. This is the dose for a couple. One dose is taken every day, one dose is decocted for two times, and three doses are taken continuously. Both men and women need to take the medicine in the same period, and women need to take the medicine after the menstruation is clear. After both male and female use three doses of the medicine, both parties have the same room, and the first course of treatment is not pregnant.

The first reason is that the number of healthy sperms of a horse is not up to the standard, and the second reason is that the drug potency of the core formula is not enough. Therefore, during the second treatment course, the pre-prepared medicine is repeatedly used for the male, so as to increase the healthy sperm count of the male. After the number of healthy sperms of the male and female is up to the standard, the treatment medicines of the male and female are adjusted, the medicine taste is increased, the medicine amount is increased, and the number of days for taking medicine is increased.

The treatment medication of the male and the female in the second course is as follows: 48g of lindera glauca root, 40g of radix linderae, 30g of madder, 60g of elaeagnus pungens root, 40g of achyranthes aspera, 35g of motherwort, 35g of glossy privet fruit, 12g of perilla, primary and secondary chicken and 5g of salt. The medicine is taken by two persons (couples) once a dose, one dose is taken every day, two times of decoction are carried out, and the couples take five consecutive days, wherein 3 primary and secondary chickens are respectively distributed in 5 doses. After the couple uses the medicine for 5 days, the woman in the month is pregnant.