阅读说明：本技术 一种去除老人味的组合物及其制剂的制备与应用 (Composition for removing old people smell and preparation and application of preparation thereof ) 是由 金青 陈永根 郝小惠 刘兴华 李微微 赵文英 谭心舜 彭佳 于 2021-10-21 设计创作，主要内容包括：本发明提供一种去除老人味的组合物、制剂及其应用,利用药用辅料结构基团吸附原理,制成针对中老年人散发气味2-壬烯醛的专用吸附制剂,借助空气净化器的过滤网,在空气置换时间内将夜间老人散发味道快速简便清除,从而达到清除空气中老年味的目的。(The invention provides a composition for removing old people odor, a preparation and application thereof, wherein a special adsorption preparation for 2-nonenal emitting odor of middle-aged and old people is prepared by utilizing a principle of medicinal auxiliary material structure group adsorption, and the odor emitted by the old people at night is quickly and simply removed in air replacement time by virtue of a filter screen of an air purifier, so that the aim of removing the old people in the air is fulfilled.)

1. a preparation method and application of a combined preparation for removing old people smell are characterized in that a harmless degradable medicinal material composition preparation is used for adsorbing 2-nonenal peculiar smell emitted by old people, and a preparation method and a use method thereof are provided.

2. The method for preparing the composition preparation for removing the old odor according to claim 1, wherein the preparation is in the form of solution, and comprises the following steps:

(1) the materials used for preparing the adsorption preparation are combined into pharmaceutic adjuvants which mainly comprise chitosan, beta-cyclodextrin and sodium glutamate.

(2) Preparing the pharmaceutical adjuvant of claim 2(1) into an adsorption preparation.

3. The preparation method of the adsorption preparation according to claim 2, wherein the formula material composition comprises pharmaceutical adjuvants of chitosan, beta-cyclodextrin and sodium glutamate, the dosage ranges of the pharmaceutical adjuvants are 1% -5%, 1% -4% and 2% -8%, and the solvent is deionized water.

4. The method of claim 2, wherein the chitosan is swollen in deionized water to form a chitosan solution; dissolving beta-cyclodextrin in deionized water at 100 ℃, and adding the dissolved beta-cyclodextrin into a chitosan solution to form a uniform and stable colloidal solution; adding sodium glutamate, stirring to dissolve completely, standing to remove air bubbles to obtain solution adsorption preparation.

5. The method of using the adsorbent preparation according to claim 1, wherein the adsorbent preparation is filled in a container with a liquid brush, and the solution is brushed to 12-15cm²The distributed dosage of the medicine/ml can be rapidly adjusted to 20-30m in 10-15min (wind speed of 1-1.5m/s)²The air in the room is replaced once, and the filter screen can be washed by tap water and dried for recycling.

Technical Field

The invention belongs to the field of public health, and particularly relates to a preparation method and an application mode of a solution preparation capable of adsorbing the old taste of which the main component is 2-nonenal. Most of the active carbon in the market is used for adsorbing odor, formaldehyde, smoke smell and other peculiar smells in the air, and the effect of removing the odor of old people is not obvious. The product of the invention adsorbs specific group structure of 2-nonenal, and can conveniently and simply remove old people smell in the air.

Background

The old taste refers to the peculiar body odor of the middle-aged and the elderly people, which is also called "old-aged odor". The earth teacher xinyilang at the research center of japan senecio found that 2-nonenal is a major cause of body odor in elderly people. With the increase of age, especially in people over 40 years old, the content of palmitoleic acid and peroxide diene in the body is increased more, and 2-nonenal is formed after oxidation. 2-nonenal has both green odor (similar to odor generated by stirring grass and vegetables) and fat odor (similar to odor generated by oxidation of fats), which causes body odor of middle-aged and elderly people. This odor is spread throughout the home, and the odor produced every night is particularly strong. The phenomenon is more obvious in a nursing home, and certain discomfort is caused to people. Most families in daily life use a purifier with activated carbon to adsorb odor, formaldehyde, smoke and the like in the air, but the removal effect is not obvious when the purifier is used for removing the odor of old people. A small number of families use bathing soaps containing polyphenol compounds to suppress the production of 2-nonenal in the middle aged and elderly people, thereby reducing the emission of odor, but this method requires the middle aged and elderly people to take a bath frequently, and is not suitable for the case of reducing the number of times of taking a bath with less secretion of oil in winter. Therefore, a simple method for reducing the bathing frequency of the old in winter and removing the odor of the old is urgently needed to be found.

The invention utilizes the principle that starch dialdehyde in a medicinal preparation can absorb free ammonia in vivo, utilizes the characteristic that 2-nonenal has carbonyl electrophilicity and is easy to form hydrogen bond in water, and utilizes harmless and easily degradable medicinal materials containing amino and hydroxyl to prepare the absorption preparation with intermolecular attraction of 2-nonenal.

The medicinal material chitosan contains polyamino, beta-cyclodextrin contains polyhydroxy, and micromolecular sodium glutamate contains amino. In weakly acidic deionized water, chitosan and beta-cyclodextrin can form a colloidal solution with high intermolecular force activity and large molecular skeleton, and the water solubility of sodium glutamate further activates surface amino, so that a large amount of active amino and hydroxyl in the system can be specifically and actively combined and adsorbed with aldehyde group part of 2-nonenal in the form of intermolecular force. In the application mode, the air purifier is uniformly coated on a filter screen of an air purifier with certain power, air flow value and air speed, so that old people smell air contained in a room with a certain area can be filtered once at fixed time. After use, the filter screen can be cleaned by tap water, and the method is simple, convenient and reliable.

The invention is used on the filter screen of the air purifier, is applied to the living environment of middle-aged and elderly people, and adsorbs the old odor, thereby overcoming the inconvenience of the old people in daily bath and specifically and effectively removing the old odor.

Disclosure of Invention

The invention aims to remove the smell of the old in the air and solve the smell problem when the old is in the place.

The invention provides a preparation system for removing the taste of old people, which is a preparation formed by taking chitosan, beta-cyclodextrin and sodium glutamate as prescription materials to adsorb the taste of old people.

The invention also provides a preparation method of the preparation system for removing the old people smell, which comprises the following process steps:

(1) weighing a proper amount of chitosan, and dissolving the chitosan in weak acid cold water to form a chitosan solution for later use.

(2) Weighing a proper amount of beta-cyclodextrin, dissolving the beta-cyclodextrin in hot water at 100 ℃, adding a chitosan solution, and stirring to form a colloidal solution for later use.

(3) Weighing a proper amount of sodium glutamate, dissolving in cold water, uniformly adding into the colloidal solution, standing to remove bubbles, and thus obtaining the adsorption preparation.

The method has the advantages that: the solution preparation has simple and convenient preparation process, strong pertinence, safety and reliability.

The use of claim 1, wherein the adsorbent is loaded into a container with a liquid brush and is uniformly applied to the filter screen of an air purifier at a dose of 12-15cm²And/ml. Under the action of wind speed of 1-1.5m/s, 20-3 can be rapidly changed within 10-15min0m²The air in the room is replaced once, so that the old people with 2-nonenal as the main component can be removed quantitatively at regular time, and the filter screen can be repeatedly used after being washed and dried by tap water, so that the method is simple, convenient and feasible.

The invention has the advantages that:

(1) the adsorption preparation can be uniformly coated on the filter screen of the air purifier, does not influence the air flow, and is convenient and simple.

(2) The adsorption preparation can remove 2-nonenal in a room with a fixed area at fixed time and quantity according to the area of a filter screen.

Drawings

FIG. 1 is a graph showing the change of the adsorption amount with the change of the adsorption time in the stationary method;

FIG. 2 is a graph showing the change of the adsorption amount with the change of the adsorption time in the kinetic method;

the above embodiments are intended to illustrate that the present invention may be implemented or used by those skilled in the art, and therefore the present invention includes, but is not limited to, the above embodiments, any methods, processes, products, etc., which are consistent with the principles and novel and inventive features disclosed herein, and which are within the scope of the present invention.

Reference documents:

[1]Keita Kimura,Yoshika Sekine,Shota Furukawa,Minami Takahashi,Daisuke Oikawa,Measurement of 2-nonenal and diacetyl emanating from human skin surface employing passive flux sampler—GCMS system,Journal of Chromatography B,Volume 1028，2016,Pages 181-185,ISSN 1570-0232。

Detailed Description

Terms used in the present invention have generally meanings as commonly understood by one of ordinary skill in the art, unless otherwise specified.

The present invention will be described in further detail with reference to the following data in conjunction with specific examples. The following examples are intended to illustrate the invention, but not to limit the scope of the invention in any way.

Two old people living in a 20 square meter room are designed, the average amount of 2-nonenal emitted by each male old people per night (8h) is 8.12ug, and the average amount of 2-nonenal emitted by each female old people per night (8h) is 7.23 ug. Two old people are in the evening (20 m)²) The odor of 2-nonenal is released at 14.47 ug-16.24 ug, and the concentration is 0.29ug/cm³—0.32ug/cm^3[1]。

The starting materials, reagents and equipment of the invention are commercially available without specific recitation, wherein:

chitosan (biochemical reagent BR, national drug group chemical agents ltd);

sodium L-glutamate, water (Biochemical reagent BR, national pharmaceutical group chemical Co., Ltd.);

beta-cyclodextrin (biotech grade BT, national drug group chemical agents limited);

2-nonenal (chromatographically pure GC, tianjin schinsen opropyco technologies ltd.);

SM830 air purifier, filter screen area 646cm²(27.4cm 23.6cm) (Siemens Co.).

Implementation example:

1. the preparation steps of the adsorption preparation are as follows:

(1) weighing 1.25g of chitosan, adding the chitosan into 25mL of 2% glacial acetic acid aqueous solution, and completely dissolving for later use.

(2) Weighing 1g of beta-cyclodextrin, adding the beta-cyclodextrin into 25mL of 100 ℃ deionized water, adding the beta-cyclodextrin into the chitosan solution after complete dissolution, and cooling to form uniform colloidal solution for later use;

(3) 2g of sodium glutamate is weighed and added into the transparent colloidal solution, and the mixture is stirred until the sodium glutamate is fully dissolved. Standing to remove bubbles to obtain 50mL of the adsorption preparation for later use.

(4) Determination of maximum adsorption by the stationary method: preparing 650mL of adsorbent according to the above formula, respectively and uniformly coating on 2-nonenal with concentration of 1.5ug/cm³Thirteen sealed bottles of the same specification (bottom radius R:4cm, volume V:460 cm)³) The amount of 2-nonenal adsorbed by the adsorbent preparation in each sealed bottle was measured at different times. The detection result shows that (see the table one below), the saturated adsorption capacity of 50mL of the adsorption preparation to the 2-nonenal is 253ug-260ug, namely the concentration is 5 ug-5.2 ug/mL, which is the saturated adsorption concentration.

(5) The maximum adsorption capacity is measured by a dynamic method: 300mL of the adsorption formulation was prepared according to the above recipe. Six closed boxes are selected and are respectively formed into 1.5ug/cm by 2-nonenal³The prepared adsorbent was uniformly coated on an air cleaner filter screen having an area of 27.4 × 23.6cm, using 50mL each time, and having a thickness of about 2 mm. An air cleaner was placed in the enclosure (enclosure size: 500 x 400 x 600mm, air cleaner size: 350 x 180 x 580 mm). At an air flow rate of 280m³And/hr, under the condition of wind speed of 1.2m/s, taking different adsorption time as independent variable, and carrying out six times of experiments to detect the content of 2-nonenal adsorbed on the filter screen. The detection result shows that (see the second table below), the saturated adsorption capacity of 50mL of the adsorption preparation to the 2-nonenal is 258ug-266ug, namely the concentration is 5.16-5.32 ug/mL.

The results of the two experiments show that the saturated adsorption capacity of 50mL of the adsorption preparation to the 2-nonenal is 255.5ug-263ug on average. According to the air replacement rate of the air purifier and the 2-nonenal content (14.47 ug-16.24 ug) emitted by the old at night, the total benefit of the economic cost and the adsorption efficiency is the best after the air purifier is used for 15 minutes.

Table one: determination of maximum adsorption by stationary method

Adsorption time (h)	0	0.5	2	8	12	24	36	48	60	72	84	96	108	120
															Adsorption capacity (ug)	0	3	15	70	100	150	180	205	222	235	242	253	256	260

Table two: determination of maximum adsorption capacity by kinetic method

Adsorption time (min)	0	5	15	30	45	60	75
								Adsorption capacity (ug)	0	50	154	220	244	258	266

(6) According to the preparation result of the adsorption preparation, 200ml of the adsorption preparation is prepared according to the same prescription for standby.

2. Mode of application

Selecting 20m²Sealing the room, and forming the room with 2-nonenal at a concentration of 0.289ug/m according to the concentration of 2 nonenal released by the elderly every night³、0.307ug/m³、0.325ug/m³The spatial concentration of (a) was uniformly coated on an air cleaner filter net having an area of 27.4 × 23.6cm, 50mL per use and a thickness of about 2mm, respectively, with the prepared adsorption preparation as in example 1, 2, and 3. At an air flow rate of 280m³Respectively adsorbing for 15 minutes in rooms with different concentrations under the wind speed condition of/hr and 1.2m/s, detecting the content of 2-nonenal on a filter screen, and calculating the purification efficiency, wherein the result is shown in a table below.

Adsorption efficiency table for adsorbent

Examples of the embodiments	Amount put (ug)	Adsorption capacity of filter screen (ug)	Purification efficiency (%)
				Examples 1	14.47	10.45	72.21
EXAMPLES example 2	15.35	10.93	71.20
				EXAMPLE 3	16.24	11.48	70.68

And (4) conclusion: in the examples, by replacing air with the air cleaner coated with the present invention, the cleaning efficiency after 15 minutes was 71.36% on average, and the residual 2-nonenal concentration in the room was 0.095ug/m³The concentration is relatively dilute, and no obvious peculiar smell exists.