阅读说明：本技术 一种冻伤膏及其制备方法 (Frostbite ointment and preparation method thereof ) 是由 石鹏飞 于 2021-09-23 设计创作，主要内容包括：本发明提出了一种冻伤膏及其制备方法,涉及冻伤药物技术领域。一种冻伤膏,其包括以下原料：桐油、猪胆汁、中药辅料、植物提取物、分散剂、抗氧化剂和防腐剂。一种冻伤膏的制备方法,包括以下步骤：将猪胆进行预处理,取出猪胆汁备用；将中药辅料进行清洗和水提,收集滤液,浓缩成清膏备用将桐油、猪胆汁和中药清膏混合进行发酵,得到发酵产物；将发酵产物与植物提取物、分散剂、抗氧化剂和防腐剂混合均匀,得到冻伤膏。本发明各种原料进行搭配可以使得冻伤膏不仅具有治愈冻伤的效果,还能对皮肤起到保湿护肤的作用。(The invention provides a frostbite ointment and a preparation method thereof, and relates to the technical field of frostbite medicines. A frostbite cream comprises the following raw materials: tung oil, pig bile, traditional Chinese medicine auxiliary materials, plant extracts, dispersing agents, antioxidants and preservatives. A preparation method of a frostbite cream comprises the following steps: pretreating fel Sus Domestica, and taking out fel Sus Domestica; cleaning and extracting the traditional Chinese medicine auxiliary materials with water, collecting filtrate, concentrating into fluid extract for later use, mixing tung oil, pig bile and the traditional Chinese medicine fluid extract, and fermenting to obtain a fermentation product; and uniformly mixing the fermentation product with the plant extract, the dispersing agent, the antioxidant and the preservative to obtain the frostbite cream. The various raw materials are matched, so that the frostbite cream not only has the effect of curing frostbite, but also has the effects of moisturizing and protecting skin.)

1. The frostbite cream is characterized by comprising the following raw materials: tung oil, pig bile, traditional Chinese medicine auxiliary materials, plant extracts, dispersing agents, antioxidants and preservatives.

2. The frostbite cream according to claim 1, characterized in that the frostbite cream comprises the following raw materials in parts by weight: 45-60 parts of tung oil, 30-50 parts of pig bile, 10-15 parts of traditional Chinese medicine auxiliary materials, 5-10 parts of plant extracts, 1-3 parts of dispersing agents, 2-5 parts of antioxidants and 0.5-2 parts of preservatives.

3. The frostbite cream according to claim 1 or 2, wherein the traditional Chinese medicine auxiliary materials comprise the following traditional Chinese medicinal materials in parts by weight: 4-7 parts of hazelnut flower, 3-5 parts of aloe, 2-4 parts of Chinese ilex leaf and 1-4 parts of Chinese sage herb.

4. The frostbite cream of claim 1 or 2, wherein the plant extract comprises one or more of lettuce extract, chamomile extract and dandelion rhizome extract.

5. The frostbite cream according to claim 1 or 2, wherein the dispersant is one or more of sodium carboxymethyl cellulose, citric acid, ethyl cellulose, sodium tripolyphosphate and calcium carboxymethyl cellulose.

6. The frostbite cream according to claim 1 or 2, wherein the antioxidant is one or more of vitamin E, sodium phytate, carotenoid, ascorbic acid, ascorbyl palmitate, isoascorbic acid, sodium isoascorbate, citric acid and phosphoric acid derivatives.

7. The frostbite cream according to claim 1 or 2, wherein the preservative is one or more of benzyl alcohol, sorbic acid, benzalkonium chloride, parabens, benzoic acid, citric acid, sodium benzoate and sodium propionate.

8. The preparation method of the frostbite cream according to any one of claims 1 to 7, characterized by comprising the following steps:

pretreating fel Sus Domestica, and taking out fel Sus Domestica;

cleaning and extracting the traditional Chinese medicine auxiliary materials with water, collecting filtrate, and concentrating into clear paste for later use;

mixing tung oil, fel Sus Domestica and Chinese medicinal fluid extract, and fermenting to obtain fermented product;

and uniformly mixing the fermentation product with the plant extract, the dispersing agent, the antioxidant and the preservative to obtain the frostbite cream.

9. The preparation method of the frostbite cream according to claim 8, wherein the pretreatment process of the pig gall is as follows: the pig gall is cleaned by clear water and then dried to be surface-dried at the temperature of 20-25 ℃.

10. The preparation method of the frostbite cream according to claim 8, wherein the fermentation step specifically comprises: adding 1-2% by mass of red yeast rice into a mixture of the tung oil, the pig bile and the Chinese medicinal clear paste, and fermenting for 10-20 days at the temperature of 20-30 ℃.

Technical Field

The invention relates to the technical field of frostbite medicines, and particularly relates to frostbite cream and a preparation method thereof.

Background

The frostbite is the tissue damage of local or whole body caused by the cold acting on the human body under certain conditions, and the severity of the frostbite is changed into a three-degree classification method from 70 years in China. The clinical manifestations are as follows: once, the lesions are in the epidermis. Localized skin redness, swelling, and major symptoms of stinging and burning, which generally heals in a short period of time. Sometimes, the sequela of local hyperhidrosis and cold feeling still exist for weeks or months. Second, damage to the dermis with local congestion and edema, and formation of fluid blisters occurs 12-24 hours after rewarming. Most of the bleb liquid is clear yellow and transparent, the bleb bottom becomes bright red, the local pain is severe, but the feeling is slow, and the acupuncture and cold-heat feeling disappear. And thirdly, the injury reaches the full layer of the skin, subcutaneous tissues and even muscles and bones. The blister liquid is mostly bloody, bright red or coffee, and the blister bottom is grey white or dirty. The skin is bluish purple, off-white, pale, or even purplish-black. For the treatment of cold injury, western medicine adopts the means of antibiosis and antiphlogosis, liquid collection, aseptic bandaging or closed treatment and the like. The traditional Chinese medicine is usually treated by a method of externally applying a single or multiple traditional Chinese medicine preparations. However, in parts of northern and southern areas of China, the frostbite generally existing in people is mostly a first-degree frostbite or a second-degree frostbite and mostly occurs at four limbs, and due to mild frostbite, even though certain pain is brought to patients, because the treatment needs a long time, most people are unwilling to receive regular system treatment in hospitals, and more hopefully, the treatment medicine has the advantages of low price, convenience in use, definite curative effect and no toxic or side effect.

At present, many drugs for treating or preventing chilblain are on the market, such as: the ointment of heparin sore limited in anticoagulation and antiphlogosis, the chilblain ointment limited in skin care and cold protection and the like are not sufficient, and the medicines have different curative effects on treating and preventing chilblain, but the medicine content is low in concentration and general in effect due to imperfect formula.

Disclosure of Invention

The invention aims to provide a frostbite cream which can effectively treat frostbite symptoms and has a long quality guarantee effect.

The invention also aims to provide a preparation method of the frostbite cream, which can be used for simply and conveniently preparing the frostbite cream.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the embodiment of the application provides a frostbite cream, which comprises the following raw materials: tung oil, pig bile, traditional Chinese medicine auxiliary materials, plant extracts, dispersing agents, antioxidants and preservatives.

On the other hand, the embodiment of the application provides a preparation method of the frostbite cream, which comprises the following steps:

pretreating fel Sus Domestica, and taking out fel Sus Domestica;

cleaning and extracting the traditional Chinese medicine auxiliary materials with water, collecting filtrate, and concentrating into clear paste for later use;

mixing tung oil, fel Sus Domestica and Chinese medicinal fluid extract, and fermenting to obtain fermented product;

and uniformly mixing the fermentation product with the plant extract, the dispersing agent, the antioxidant and the preservative to obtain the frostbite cream.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

the invention adopts the tung oil and the pig bile as the main raw materials of the frostbite plaster, the tung oil has the efficacy of treating scabies, ecthyma, hot water and fire injuries and chilblain chap by external application, and has the functions of corrosion prevention and lubrication, the pig bile has better bacteriostasis and healing effects, the two are matched to play the roles of bacteriostasis, diminishing inflammation and promoting healing, and can play a very good role in sterilizing and healing frostbite; the traditional Chinese medicine auxiliary materials are added into the frostbite ointment, so that the effects of stopping bleeding and removing blood stasis are improved, the plant extract is added, the moisturizing effect is improved, and the dispersing agent and the antioxidant are added, so that the phenomena of non-uniform medicine effect and fading caused by layering of the frostbite ointment after long-term standing can be prevented; the preservative is added, so that the shelf life of the frostbite cream can be effectively prolonged. The various raw materials are matched, so that the frostbite cream not only has the effect of curing frostbite, but also has the effects of moisturizing and protecting skin.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

A frostbite cream comprises the following raw materials: tung oil, pig bile, traditional Chinese medicine auxiliary materials, plant extracts, dispersing agents, antioxidants and preservatives.

In some embodiments of the invention, the frostbite cream comprises the following raw materials in parts by weight: 45-60 parts of tung oil, 30-50 parts of pig bile, 10-15 parts of traditional Chinese medicine auxiliary materials, 5-10 parts of plant extracts, 1-3 parts of dispersing agents, 2-5 parts of antioxidants and 0.5-2 parts of preservatives.

In some embodiments of the present invention, the traditional Chinese medicine auxiliary materials comprise the following traditional Chinese medicinal materials in parts by weight: 4-7 parts of hazelnut flower, 3-5 parts of aloe, 2-4 parts of Chinese ilex leaf and 1-4 parts of Chinese sage herb.

Hazelnut flower: sweet in taste and neutral in nature; entering lung and kidney meridians; has hemostatic, repercussive, and sore healing effects.

Aloe vera: bitter taste and cold nature; clearing away heat, relieving constipation, and killing bacteria. It is used to treat constipation due to heat accumulation, amenorrhea, infantile convulsion, infantile malnutrition, fever, insect accumulation, tinea, hemorrhoid and fistula, atrophic rhinitis, and lymphoid tuberculosis.

Leaf of Chinese ilex: bitter and astringent taste and cold nature; it can be used for treating scald, ulcer, obliterative angiitis, acute and chronic bronchitis, pneumonia, urinary tract infection, bacillary dysentery, traumatic hemorrhage, cold injury chilblain, and rhagadia.

Chinese sage herb: bitter and pungent taste, mild in nature; it is indicated for dysphagia, phlegm dyspnea, hepatitis, red and white leucorrhea, carbuncle and scrofula.

The invention adopts hazelnut flower to stop bleeding and relieve swelling, then aloe is sterilized, Chinese ilex leaf and Chinese sage herb promote healing, and tung oil and pig bile are comprehensively assisted to play a role in treating frostbite.

In some embodiments of the present invention, the plant extract comprises one or more of lettuce extract, chamomile extract, and dandelion rhizome extract.

The lettuce is sweet in taste and cold in nature; entering intestines and stomach meridians; has effects in benefiting five internal organs, dredging channels and collaterals, clearing stomach heat, and promoting urination; can be used for treating dysuria, hematuria, and galactostasis. The lettuce extract can relieve the skin sensitivity by external application, quickly supplement the skin nutrition and moisture and play a role in moisturizing.

The chamomile flower can well relieve skin and resist skin sensitivity, and has the effects of resisting inflammation, bacteria and oxidation.

The herba Taraxaci is rich in microorganism A, vitamin C and minerals, and has effect of relieving dermatitis.

The lettuce extract, the chamomile extract and the dandelion extract are adopted to relieve the stimulation of other raw materials to the frostbite part, and have the effects of diminishing inflammation and preserving moisture on the frostbite part.

In some embodiments of the present invention, the dispersant is one or more of sodium carboxymethyl cellulose, citric acid, ethyl cellulose, sodium tripolyphosphate, and calcium carboxymethyl cellulose.

In some embodiments of the present invention, the antioxidant is one or more of vitamin E, sodium phytate, carotenoid, ascorbic acid, ascorbyl palmitate, erythorbic acid, sodium erythorbate, citric acid and phosphoric acid derivative.

In some embodiments of the present invention, the preservative is one or more of benzyl alcohol, sorbic acid, benzalkonium chloride, p-hydroxybenzoate, benzoic acid, citric acid, sodium benzoate, and sodium propionate.

A preparation method of a frostbite cream comprises the following steps:

pretreating fel Sus Domestica, and taking out fel Sus Domestica;

cleaning and extracting the traditional Chinese medicine auxiliary materials with water, collecting filtrate, and concentrating into clear paste for later use;

mixing tung oil, fel Sus Domestica and Chinese medicinal fluid extract, and fermenting to obtain fermented product;

and uniformly mixing the fermentation product with the plant extract, the dispersing agent, the antioxidant and the preservative to obtain the frostbite cream.

In some embodiments of the present invention, the pretreatment process of the pig gall comprises: the pig gall is cleaned by clear water and then dried to be surface-dried at the temperature of 20-25 ℃.

In some embodiments of the present invention, the fermentation step is specifically: adding 1-2% by mass of red yeast rice into a mixture of the tung oil, the pig bile and the Chinese medicinal clear paste, and fermenting for 10-20 days at the temperature of 20-30 ℃.

The application method of the frostbite cream comprises the following steps: cleaning the affected part with saline water, smearing the frostbite ointment on the affected part, and then uniformly smearing the ointment on the affected part, and then wearing disposable gloves or winding the ointment with a preservative film.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

A frostbite ointment comprises the following preparation method:

cleaning fresh fel Sus Domestica with clear water for 2 times, sun drying the epidermis, and taking out the internal fel Sus Domestica bile;

weighing 20g of hazelnut flower, 20g of aloe, 20g of Chinese ilex leaf and 20g of Chinese sage herb, cleaning for 2 times by using clear water, adding 10 times of water by mass, boiling with big fire, then decocting with soft fire for 3 hours, filtering to obtain filtrate, and concentrating the filtrate into clear paste with the proportion of 1.1 for later use;

mixing 500g of tung oil, 400g of pig bile and 100g of Chinese medicinal fluid extract uniformly, adding 15g of red yeast rice, stirring uniformly, and placing in an environment of 25 ℃ for sealed fermentation for 15 days to obtain a fermentation product;

the fermented product was mixed uniformly with 50g of lettuce extract, 20g of citric acid, 30g of ascorbic acid and 10g of sorbic acid to obtain the cream for frostbite of this example.

The frostbite cream of this embodiment is oily yellow thick lotion, washs frostbite department with salt solution during the use earlier, paints frostbite cream in the affected part after drying, then wraps up with disposable gloves or plastic wrap. The frostbite cream is preferably used at night, and the intervention on the wound is reduced. The cold injury paste after unsealing is placed carefully to prevent children from eating the paste.

Example 2

A frostbite ointment comprises the following preparation method:

cleaning fresh fel Sus Domestica with clear water for 2 times, sun drying the epidermis, and taking out the internal fel Sus Domestica bile;

weighing 70g of hazelnut flower, 30g of aloe, 40g of Chinese ilex leaf and 10g of Chinese sage herb, cleaning for 2 times by using clear water, adding 12 times of water by mass, boiling with big fire, then decocting with small fire for 2.5 hours, filtering to obtain filtrate, and concentrating the filtrate into clear paste with the proportion of 1.15 for later use;

mixing 600g of tung oil, 500g of pig bile and 150g of Chinese medicinal fluid extract, adding 18g of red yeast rice, stirring, and sealing and fermenting at 30 deg.C for 12 days to obtain fermented product;

the fermented product was mixed with 80g of chamomile flower extract, 10g of sodium tripolyphosphate, 20g of carboxymethylcellulose calcium, 20g of carotenoid, 10g of benzyl alcohol and 10g of paraben uniformly to obtain the cream for frostbite of the present example.

Example 3

A frostbite ointment comprises the following preparation method:

cleaning fresh fel Sus Domestica with clear water for 3 times, sun drying the epidermis, and taking out the internal fel Sus Domestica bile;

weighing 40g of hazelnut flower, 50g of aloe, 20g of Chinese ilex leaf and 40g of Chinese sage herb, cleaning for 3 times by using clear water, adding 11 times of water by mass to boil with big fire, then boiling for 2 hours with small fire, pouring out the filtrate, adding 9 times of water by mass to the filter residue, boiling for 2 hours with big fire, pouring out the filtrate, combining the two filtrates, and concentrating to obtain a clear paste with a ratio of 1.2 for later use;

taking 450g of tung oil, 400g of pig bile and 120g of Chinese medicinal extract, mixing uniformly, adding 11g of red yeast rice, stirring uniformly, and placing in an environment of 20 ℃ for sealed fermentation for 15 days to obtain a fermentation product;

the fermentation product was uniformly mixed with 50g of dandelion rhizome extract, 50g of lettuce extract, 10g of carboxymethylcellulose calcium, 10g of ethylcellulose, 10g of ascorbic acid, 10g of ascorbyl palmitate, and 5g of benzalkonium chloride to obtain the cold injury cream of the present example.

Example 4

A frostbite ointment comprises the following preparation method:

cleaning fresh fel Sus Domestica with clear water for 2 times, sun drying the epidermis, and taking out the internal fel Sus Domestica bile;

weighing 50g of hazelnut flower, 50g of aloe, 30g of Chinese ilex leaf and 20g of Chinese sage herb, cleaning for 3 times by using clear water, adding 12 times of water by mass to boil with big fire, then boiling for 2 hours with small fire, pouring out the filtrate, adding 9 times of water by mass to the filter residue, boiling with big fire for 1 hour, pouring out the filtrate, combining the two filtrates, and concentrating to obtain a clear paste with a ratio of 1.18 for later use;

taking 550g of tung oil, 300g of pig bile and 100g of Chinese medicinal fluid extract, mixing uniformly, adding 17g of red yeast rice, stirring uniformly, and placing in an environment of 20 ℃ for sealed fermentation for 10 days to obtain a fermentation product;

the fermentation product was mixed uniformly with 50g of dandelion rhizome extract, 30g of lettuce extract, 10g of carboxymethylcellulose calcium, 10g of ethylcellulose, 10g of ascorbic acid, 10g of ascorbyl palmitate and 5g of benzoic acid to obtain the cream for cold injury of the present example.

Example 5

A frostbite ointment comprises the following preparation method:

cleaning fresh fel Sus Domestica with clear water for 2 times, sun drying the epidermis, and taking out the internal fel Sus Domestica bile;

weighing 70g of hazelnut flower, 30g of aloe, 30g of Chinese ilex leaf and 20g of Chinese sage herb, cleaning for 3 times by using clear water, adding 11 times of water by mass to boil with big fire, then boiling for 2 hours with small fire, pouring out the filtrate, adding 9 times of water by mass to the filter residue, boiling for 1 hour with big fire, pouring out the filtrate, combining the two filtrates, and concentrating to obtain a clear paste with a ratio of 1.2 for later use;

mixing 600g of tung oil, 400g of pig bile and 100g of Chinese medicinal fluid extract, adding 18g of red rice, stirring, and sealing and fermenting at 20 deg.C for 10 days to obtain fermented product;

the fermentation product was mixed uniformly with 70g of dandelion rhizome extract, 30g of lettuce extract, 10g of carboxymethylcellulose calcium, 10g of ethylcellulose, 15g of ascorbic acid, 10g of ascorbyl palmitate and 5g of benzoic acid to obtain the cream for cold injury of the present example.

Example 6

A frostbite ointment comprises the following preparation method:

cleaning fresh fel Sus Domestica with clear water for 3 times, sun drying the epidermis, and taking out the internal fel Sus Domestica bile;

weighing 40g of hazelnut flower, 20g of aloe, 20g of Chinese ilex leaf and 30g of Chinese sage herb, cleaning for 2 times by using clear water, adding 10 times of water by mass, boiling with big fire, then decocting with soft fire for 3 hours, filtering to obtain filtrate, and concentrating the filtrate into clear paste with the proportion of 1.1 for later use;

mixing 500g of tung oil, 400g of pig bile and 100g of Chinese medicinal fluid extract, adding 18g of red yeast rice, stirring, and sealing and fermenting at 27 deg.C for 12 days to obtain fermented product;

the fermented product was mixed uniformly with 50g of lettuce extract, 20g of citric acid, 30g of ascorbic acid and 10g of sorbic acid to obtain the cream for frostbite of this example.

Comparative example 1

This comparative example differs from example 1 in that no plant extract was added.

The preparation method comprises the following steps: cleaning fresh fel Sus Domestica with clear water for 2 times, sun drying the epidermis, and taking out the internal fel Sus Domestica bile;

weighing 20g of hazelnut flower, 20g of aloe, 20g of Chinese ilex leaf and 20g of Chinese sage herb, cleaning for 2 times by using clear water, adding 10 times of water by mass, boiling with big fire, then decocting with soft fire for 3 hours, filtering to obtain filtrate, and concentrating the filtrate into clear paste with the proportion of 1.1 for later use;

mixing 500g of tung oil, 400g of pig bile and 100g of Chinese medicinal fluid extract uniformly, adding 15g of red yeast rice, stirring uniformly, and placing in an environment of 25 ℃ for sealed fermentation for 15 days to obtain a fermentation product;

the fermented product was uniformly mixed with 20g of citric acid, 30g of ascorbic acid and 10g of sorbic acid to obtain a cream for cold injury of this example.

Comparative example 2

This comparative example differs from example 1 in that no dispersant and no antioxidant were added.

The preparation method comprises the following steps: cleaning fresh fel Sus Domestica with clear water for 2 times, sun drying the epidermis, and taking out the internal fel Sus Domestica bile;

weighing 20g of hazelnut flower, 20g of aloe, 20g of Chinese ilex leaf and 20g of Chinese sage herb, cleaning for 2 times by using clear water, adding 10 times of water by mass, boiling with big fire, then decocting with soft fire for 3 hours, filtering to obtain filtrate, and concentrating the filtrate into clear paste with the proportion of 1.1 for later use;

mixing 500g of tung oil, 400g of pig bile and 100g of Chinese medicinal fluid extract uniformly, adding 15g of red yeast rice, stirring uniformly, and placing in an environment of 25 ℃ for sealed fermentation for 15 days to obtain a fermentation product;

the fermented product was mixed uniformly with 50g of lettuce extract and 10g of sorbic acid to give the cream for cold injury of this example.

Comparative example 3

The difference between the comparative example and the example 1 is that no traditional Chinese medicine auxiliary materials are added in the comparative example.

A frostbite ointment comprises the following preparation method:

cleaning fresh fel Sus Domestica with clear water for 2 times, sun drying the epidermis, and taking out the internal fel Sus Domestica bile;

uniformly mixing 500g of tung oil and 400g of pig bile, adding 15g of red yeast rice, uniformly stirring, and placing in an environment of 25 ℃ for sealed fermentation for 15 days to obtain a fermentation product;

the fermented product was mixed uniformly with 50g of lettuce extract, 20g of citric acid, 30g of ascorbic acid and 10g of sorbic acid to obtain the cream for frostbite of this example.

Comparative example 4

The comparative example differs from example 1 in that no pig bile was added.

A frostbite ointment comprises the following preparation method:

weighing 20g of hazelnut flower, 20g of aloe, 20g of Chinese ilex leaf and 20g of Chinese sage herb, cleaning for 2 times by using clear water, adding 10 times of water by mass, boiling with big fire, then decocting with soft fire for 3 hours, filtering to obtain filtrate, and concentrating the filtrate into clear paste with the proportion of 1.1 for later use;

mixing 500g of tung oil and 100g of Chinese medicinal fluid extract uniformly, adding 15g of red rice, stirring uniformly, and placing in an environment of 25 ℃ for sealed fermentation for 15 days to obtain a fermentation product;

the fermented product was mixed uniformly with 50g of lettuce extract, 20g of citric acid, 30g of ascorbic acid and 10g of sorbic acid to obtain the cream for frostbite of this example.

Experimental example 1

The frostbite creams prepared in examples 1 to 4 and comparative examples 1 to 4 were allowed to stand at 5 ℃, 20 ℃ and 35 ℃ respectively, and the morphology was observed after 10 days, and the results are shown in table 1.

TABLE 1

As can be seen from Table 1, the dispersant and the antioxidant were added to the mixture, and the mixture was not separated even when it was left at a low temperature (5 ℃ C.), a normal temperature (20 ℃ C.) or a high temperature (35 ℃ C.) for 10 days, indicating that the mixture had stable properties.

Experimental example 2

396 patients with frostbite are collected, wherein 262 patients with mild frostbite and 134 patients with moderate or severe frostbite are randomly divided into 10 experimental groups, and the data of the patients with mild frostbite and the data of the patients with moderate or severe frostbite of each experimental group are basically balanced, wherein the experimental groups 1-8 respectively adopt the chilblain creams prepared in the embodiments 1-4 and the comparative examples 1-4, the experimental group 9 adopts vaseline frostbite cream, and the experimental group 10 is a blank experimental group and is smeared with normal saline; the smearing method comprises the following steps: saline water cleaning is carried out on the frostbite part before sleeping at night every day, plaster smearing is carried out after air drying, disposable gloves or preservative films are used for wrapping after smearing, the treatment effect is counted after 1 month, and the result is shown in table 2.

TABLE 2

It can be seen from table 2 that the effective rate of the frostbite cream prepared by embodiments 1-4 is 97% or more, the effective rate of the experimental group 5 is high, but the cure rate is obviously lower than that of the experimental groups 1-4, and the affected part of the patient is dry, so that the healing effect is slow, the frostbite cream of the experimental group 6 has obvious layering after being placed for 5 days, thereby the drug effect is reduced, the effective rates of the experimental group 7 and the experimental group 8 are obviously lower than that of the experimental group 1, and the pig bile and the traditional Chinese medicine auxiliary materials are used for treating frostbite.

Typical case 1, a forest, a woman and a 18 year old, finger and toe frostbite occurs in 2014, chilblain is grown in winter every year, skin is red, swollen and congested, the warm place feels hot and itchy, the cold place feels pain and can crack when the pain is severe, 2017, the frostbite ointment prepared in example 1 is introduced into the place, a layer of the frostbite ointment is smeared on the frostbite before sleeping at night, the frostbite ointment is wrapped by a preservative film, symptoms are obviously relieved after one week, the feeling of itching and pain basically disappears, the red and swollen part is reduced in swelling after 1 month of continuous use, the cracked part is scabbed, the frostbite part is healed after 2 months, and the frostbite is not relapsed again after years of winter.

Typical case 2, a certain grandfather, a man, a 58 year old, a person who is on business in the winter of 2019 is frostbitten, the face is red and swollen, the face cannot touch, the body is locally soaked, the body is cold, the frostbite disease is diagnosed, and the frostbite ointment prepared by the embodiment 1 is used once before sleeping every night and is recovered after visiting 15 days.

In summary, the frostbite cream and the preparation method thereof provided by the embodiments of the invention are provided. The invention adopts the tung oil and the pig bile as the main raw materials of the frostbite plaster, the tung oil has the efficacy of treating scabies, ecthyma, hot water injury and chilblain chap by external application, the pig bile has better bacteriostasis and healing effects, and the matching of the tung oil and the pig bile can have very good treatment effect on frostbite; the traditional Chinese medicine auxiliary materials are added into the frostbite ointment, so that the effects of stopping bleeding and removing blood stasis are improved, the plant extract is added, the moisturizing effect is improved, and the dispersing agent and the antioxidant are added, so that the phenomena of non-uniform medicine effect and fading caused by layering of the frostbite ointment after long-term standing can be prevented; the preservative is added, so that the shelf life of the frostbite cream can be effectively prolonged. The various raw materials are matched, so that the frostbite cream not only has the effect of curing frostbite, but also has the effects of moisturizing and protecting skin.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.