阅读说明：本技术 一种治疗便秘的中药组合物及制备方法 (Traditional Chinese medicine composition for treating constipation and preparation method thereof ) 是由 许平 于 2021-08-27 设计创作，主要内容包括：本发明公开了一种治疗便秘的中药组合物及制备方法,中药组合物由一定比例的枳实、白术、肉苁蓉、女贞子、当归、海藻组成,步骤是：A、干燥：按比例称取各原料,分别进行干燥；B、粉碎：对各原料分别进行粉碎,每次控制一定时间,过110-130目筛后的各原料再进行粉碎,反复进行；C、混合：将粉碎后的各原料细粉混合均匀,得混合物；D、起母子：将混合物的药粉置于圆竹簸箕中,再用刷子蘸凉开水,洒在药粉上形成小药粉珠；E、药丸：将药粉珠放置到水平面簸箕中摇动簸箕,使药粉珠在簸箕中滚动,继续粘上药粉,干燥后的药丸保存。使用方便,治疗效果高,无毒副作用,便于吞服,又不易吸潮,有利于保管贮存和携带。适用于包括糖尿病在内的所有人群。(The invention discloses a Chinese medicinal composition for treating constipation and a preparation method thereof, wherein the Chinese medicinal composition comprises immature bitter orange, largehead atractylodes rhizome, desertliving cistanche, glossy privet fruit, Chinese angelica and seaweed in a certain proportion, and the steps are as follows: A. and (3) drying: weighing the raw materials in proportion, and respectively drying; B. crushing: respectively crushing the raw materials, controlling the raw materials for a certain time each time, and crushing the raw materials which are sieved by a 110-sand-screen 130-mesh sieve repeatedly; C. mixing: uniformly mixing the crushed raw material fine powder to obtain a mixture; D. starting a mother and a son: placing the powder in a bamboo dustpan, and spraying the powder with a brush in cold boiled water to form small powder beads; E. pill preparation: placing the medicinal powder bead into a horizontal dustpan, shaking the dustpan to make the medicinal powder bead roll in the dustpan, continuously sticking the medicinal powder, and storing the dried pill. Convenient use, high treatment effect, no toxic or side effect, convenient swallowing, difficult moisture absorption and favorable storage and carrying. Is suitable for all people including diabetes.)

1. A traditional Chinese medicine composition for treating constipation comprises the following raw materials in parts by weight:

the preparation method of the traditional Chinese medicine composition comprises the following steps:

A. and (3) drying: weighing immature bitter orange, bighead atractylodes rhizome, cistanche, glossy privet fruit, Chinese angelica and seaweed according to a certain proportion, and respectively drying: controlling the water content within 5 percent in a microwave oven for 2 minutes;

B. crushing: respectively crushing the immature bitter orange, the bighead atractylodes rhizome, the cistanche, the glossy privet fruit, the Chinese angelica and the seaweed, wherein each time is 14-16 minutes, then sieving the crushed immature bitter orange, the white atractylodes rhizome, the cistanche, the glossy privet fruit, the Chinese angelica and the seaweed by a sieve of 110-130 meshes, crushing the raw materials passing through the sieve again, and repeatedly crushing and sieving the raw materials for 3-5 times;

C. mixing: uniformly mixing the pulverized fructus Aurantii Immaturus, Atractylodis rhizoma, Cistanchis herba, fructus Ligustri Lucidi, radix Angelicae sinensis, and Sargassum fine powder to obtain a mixture;

D. starting a mother and a son: putting the medicinal powder of the mixture obtained in the step (C) into a bamboo dustpan, dipping the medicinal powder into fresh boiled cold water by using a brush, and spraying the medicinal powder onto the medicinal powder to form small medicinal powder beads;

E. pill preparation: and (D) placing the medicinal powder beads in the step (D) into a dustpan on a horizontal plane, shaking the dustpan to enable the medicinal powder beads to roll in the dustpan, continuously sticking the medicinal powder to form pills with uniform bean granules, pouring the pills into another dustpan, flatly spreading the pills to dry or sun-drying the pills, and sealing and storing the dried pills.

2. The traditional Chinese medicine composition for treating constipation according to claim 1, which is characterized in that:

3. the traditional Chinese medicine composition for treating constipation according to claim 1, which is characterized in that:

4. the traditional Chinese medicine composition for treating constipation according to claim 1, which is characterized in that:

。

5. the traditional Chinese medicine composition for treating constipation according to claim 1, which is characterized in that:

6. the traditional Chinese medicine composition for treating constipation according to claim 1, which is characterized in that:

7. the traditional Chinese medicine composition for treating constipation according to claim 1, which is characterized in that:

Technical Field

The invention belongs to the technical field of traditional Chinese medicine pills for treating constipation, and particularly relates to a traditional Chinese medicine composition (pill) for treating constipation, and a preparation method of the traditional Chinese medicine composition (pill) for treating constipation, which is suitable for treating adult constipation caused by hemorrhoids, anal fissure, anal injury, chronic constipation, anal sinusitis, constipation after anal operation, postpartum constipation of women, medicines, diabetes and the like.

Background

Constipation is a common disease with an incidence rate of 35-45%, even up to more than 50% in middle-aged and elderly people. Constipation causes anal diseases (hemorrhoids, anal fissure, anal injury, anal sinusitis, etc.), aggravates cardiovascular and cerebrovascular diseases, forms abdominal hernia, impairs beauty, causes decreased libido, and brings psychological and mental stress hazards. Seriously affecting the life quality of people. Solves the problem of constipation and has great significance for improving the quality of life.

The traditional medicines for treating constipation are generally purgative medicines and gastrointestinal motility medicines. Especially, the original Chinese patent medicine compound or single medicine which takes catharsis as the main function has more or less side effects, or contains toxic components, or causes the defects and the defects of abdominal pain, diarrhea, water diarrhea, incontinence, constipation after diarrhea and the like.

The main defects and deficiency problems are analyzed as follows:

the single medicine for treating constipation and the compound name containing the corresponding single medicine are as follows:

1. the single medicine or compound medicine containing rhubarb or rhubarb components is easy to cause abdominal pain and diarrhea and constipation after diarrhea: radix et rhizoma Rhei, folium sennae, Polygoni Multiflori radix, Aloe (sic), caulis Polygoni Multiflori, radix Rumicis Japonici, and rhizoma Polygoni Cuspidati. Fructus Cannabis pill, fructus Cannabis capsule, toxin expelling and skin caring capsule, etc.

2. Contains sulfur: and BAISHI pill (rhizoma Pinelliae and Sulfur).

3. Laxatives containing salts: magnesium sulfate and sodium salt (Natrii sulfas ) are prone to diarrhea, incontinence, water electrolyte balance disorder, and sodium and magnesium poisoning.

4. Contains toxic protein: castor kernel (oil) contains ricin.

5. Containing hydrocyanic acid species: peach kernel, almond, bunge cherry seed, etc.

6. Contains arecoline: areca seed, Simo drink (ginseng, areca seed, eaglewood, lindera root), arecoline can cause severe abdominal pain.

7. Contains a large amount of tannic acid: rhubarb, etc. aggravate constipation after diarrhea.

8. Contains muscarine and choline: fructus Cannabis.

9. Dose-dependent, easily developing resistance: a medicine contains effective components of radix et rhizoma Rhei.

Secondly, common traditional Chinese medicine composition for treating constipation:

1. qirong Runchang oral liquid (Beijing Beiwei pharmaceutical industry)

Consists of the following components: astragalus membranaceus, cistanche deserticola, bighead atractylodes rhizome, radix pseudostellariae, rehmannia glutinosa, radix scrophulariae, radix ophiopogonis, angelica sinensis, rhizoma polygonati, mulberry, black sesame, fructus aurantii, bunge cherry seed, fructus cannabis and honey.

2. Fructus Cannabis pill (honeyed pill, Tongrentang)

Consists of the following components: fructus cannabis, bitter apricot seed, rhubarb, immature bitter orange, officinal magnolia bark, white paeony root and honey.

3. The soft capsule of edestan comprises: fructus Cannabis, semen Armeniacae amarum, radix et rhizoma Rhei, fructus Aurantii Immaturus, cortex Magnolia officinalis, and radix Paeoniae alba.

In the three common compositions, 1 and 2 contain honey which is used as a binding agent or a flavoring agent, and the honey has the effect of relaxing bowel, but is not suitable for people with diabetes. All three compositions contain fructus Cannabis, which contains hydrocyanic acid as a toxic component, like semen Pruni, semen Armeniacae amarum, and semen Persicae. 2. 3, the rhubarb is the most common traditional cathartic, which is easy to cause abdominal pain and diarrhea, and the rhubarb contains a large amount of tannic acid, so that constipation is easy to occur after the cathartic action is generated, and the constipation is aggravated. Rhubarb belongs to an irritant laxative, long-term irritation can cause the enteric wall nerve to lose sensitivity, the phenomenon that the dosage is increased to achieve the effect of relaxing the bowels is often seen clinically, but more tannic acid components enter the body at the same time, the side effect of constipation is more obvious, and the vicious circle is formed.

In the preparation method, 1 and 3 are crude drug extracts, do not contain drug residues, are convenient to take, but cannot increase the volume and weight of excrement. In comparison, the composition 2 (fructus cannabis pill) directly takes the medicinal materials as pills, the medicinal material residues are reserved, and the volume of excrement can be directly increased after the composition is taken into the gastrointestinal tract of a human body, so that the composition is beneficial to defecation.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition (pill) for treating constipation, which has the advantages of reasonable formula, convenient use, high treatment effect and no toxic or side effect, and is suitable for all people including diabetes.

The invention also aims to provide a preparation method of the traditional Chinese medicine composition (pill) for treating constipation, which is easy to implement and simple and convenient to operate, and all the medicinal material fine powder is prepared into pills and pills, so that the pill is small in volume, compact and smooth in surface, convenient to swallow, not easy to absorb moisture, and favorable for storage, storage and carrying.

In order to achieve the purpose, the invention adopts the following technical measures:

a traditional Chinese medicine composition (pill) for treating constipation comprises the following raw materials in parts by weight:

a traditional Chinese medicine composition (pill) for treating constipation comprises the following raw materials in parts by weight:

a traditional Chinese medicine composition (pill) for treating constipation comprises the following raw materials in parts by weight:

a traditional Chinese medicine composition (pill) for treating constipation comprises the following raw materials in parts by weight:

a traditional Chinese medicine composition (pill) for treating constipation comprises the following raw materials in parts by weight:

the six raw materials are the most critical: the composition comprises three components of glossy privet fruit, desertliving cistanche and seaweed, so the composition accounts for two thirds of the weight ratio, and the composition accounts for only one third of the weight ratio because the composition is prepared from immature bitter orange, largehead atractylodes rhizome and Chinese angelica. The invention relates to a traditional Chinese medicine theory basis which is 'liquid increasing boat moving', constipation and dry excrement are visually regarded as that the boat moving is difficult to carry on in a dry river bed, when the river bed is filled with water (the water in an intestinal tract is increased), the boat can sail easily, and the modern medical theory is that the liquid amount of the intestinal tract is recovered, the excrement volume is increased, and the excrement is easy to discharge. The rhubarb drugs and the composition are not used for simply stimulating the nerve cells on the intestinal wall to play a role in defecation, so that the phenomenon that the nerve on the intestinal wall depends on drug property after long-term use is avoided, the stimulating laxative defecation mainly increases the intestinal peristalsis, shortens the stay time of the excrement in the intestinal tract, absorbs less water, overcomes the defect of dry excrement, but has the problems or side effects of too fast and hyperfunction of the intestinal peristalsis, influence on the absorption of nutrient components, thin defecation, easy abdominal pain and easy diarrhea and the like.

The effective components of the three medicines, namely the glossy privet fruit, the cistanche and the seaweed, are D-mannitol and D-mannitol which can not be absorbed basically when being taken orally, and form a relatively hypertonic environment in an intestinal tract, so that moisture outside the intestine can enter the intestinal tract, the volume and the water content of excrement are increased, the excrement is softened, the defecation intention and the intestinal peristalsis are triggered, and the excrement is promoted and conveniently discharged out of the body.

The main medical indication of the mannitol which is accepted and related to the invention is intestinal tract cleaning preparation, the conventional usage is that 250 ml (containing 50 g of mannitol) of 20% mannitol liquid medicine is mixed with 1000 ml of water for oral administration, and the main purpose is to completely discharge intestinal tract excrement and hydrops, facilitate examination or operation and often discharge multiple times of excrement and watery discharge. Because the mannitol is taken at one time in an amount of 50 g, the large dose is not suitable for treating patients with constipation, and long-term large defecation and watery diarrhea can cause water electrolyte balance disorder and even endanger life.

To solve the above problem, the applicant experimented with the observation of the doses of oral mannitol, given separately: 0.5 g, 1.0 g, 2.0 g and 5.0 g, and the effect of softening the stool and recovering normal defecation can be observed when 0.5-1.0 g is observed. More than 1.0 g of the oral liquid is easy to cause abdominal pain and diarrhea, and has obvious side effect, which indicates that the mannitol is clinically taken orally to achieve the effect of relaxing bowels and treat constipation without abdominal pain and diarrhea, and the dosage is controlled within 1.0 g per day. And the dosage of more than 1.0 g produces the effect of cleaning the intestinal tract, can cause a plurality of times of diarrhea and water defecation, and can only be temporarily prepared for the intestinal tract before the enteroscopy or the intestinal tract operation. Doses above 1.0 gram per day cannot be routinely administered, thus avoiding side effects. Meanwhile, the following glossy privet fruit, cistanche and seaweed containing mannitol components can be selected, and the mannitol content of the three medicaments per day is within 1.0 g.

The mannitol content of the glossy privet fruit, the cistanche and the seaweed is 3.6%, 2.5% and 7.6% respectively, 20 g of the traditional Chinese medicine composition is orally taken every day, the dosage of the traditional Chinese medicine composition, the cistanche and the seaweed is about 14 g, the content of an effective component D-mannitol is about 0.6 g, and the stool softening effect is obvious. The difficult problem of watery diarrhea is solved because the dosage of D-mannitol every day is controlled and the dosage is small.

D-mannitol can be used as food additive and has anti-adhesion effect, which can explain that the discharged excrement does not stick to anus skin and a closestool and is easy to wipe and wash after the traditional Chinese medicine composition related to the invention is orally taken.

The seaweed also contains abundant cellulose, and has effects of absorbing water, expanding volume, increasing volume and quantity of feces, and recovering normal volume and humidity of feces. The seaweed is selected because the common natural raw material for extracting and producing the mannitol in China is the kelp, namely one of the seaweeds, and the seaweeds not only are pregnant with the mannitol, but also have the cellulose content of 27 percent.

The less important medicaments of the invention, namely the immature bitter orange and the white atractylodes rhizome, mainly have a two-way regulating effect on gastrointestinal tracts, solve the problem of gastrointestinal motility weakening, recover the gastrointestinal motility and simultaneously relieve the outlet obstruction type constipation caused by anal sphincter achalasia and reverse contraction. The bidirectional regulating function is obviously improved compared with the prior composition. The theory of traditional Chinese medicine is to strengthen spleen and stomach, eliminate food retention, recover the digestion and absorption function, not to influence the normal absorption of nutrient components, and solve the problem that the absorption of nutrient substances is influenced by irritant laxatives.

The integration effect solves the technical problems of less water, low humidity, dryness, small volume, difficulty in causing defecation, difficult discharge, gastrointestinal hypomotility, dyspepsia, diarrhea and the like.

The invention relates to a traditional Chinese medicine composition which is prepared from the following components in parts by weight: immature bitter orange, largehead atractylodes rhizome, desertliving cistanche, glossy privet fruit, Chinese angelica, seaweed, fresh cool boiled water and the like, and the prepared medicine has the following functions and effects.

The theory of traditional Chinese medicine considers that kidney is affected by long-term disease, deficiency is caused by long-term disease, collateral is caused by long-term disease, and stasis is caused by long-term disease. Therefore, the problem of chronic constipation is solved, the problem of kidney deficiency is considered to be solved, the traditional Chinese patent medicine 'Erzhi pill' (composed of glossy privet fruit and eclipta alba) is found to have the function of relaxing the bowels when being used for treating the white hair, and the eclipta alba contains a large amount of tannic acid and cannot be an effective medicine for relaxing the bowels. The glossy privet fruit has the effects of nourishing liver and kidney, mainly tonifying kidney yin, contains D-mannitol, is an effective medicament for relaxing bowels, focuses on yin-yang balance and kidney yang balance according to the theory of treatment based on syndrome differentiation of traditional Chinese medicine, and has the function of relaxing bowels. The raw material for industrially producing mannitol is seaweed, kelp, so that seaweed is selected. The angelica is selected, contains rich vitamins and trace elements, and has the functions of promoting blood circulation to remove blood stasis, improving microcirculation, nourishing nerves, removing blood stasis and dredging collaterals according to the traditional Chinese medicine theory. The immature bitter orange and the white atractylodes rhizome have the effects of strengthening the spleen and the stomach, regulating the gastrointestinal function and recovering the intestinal power and the digestion and absorption function, so that the difficult problem of relaxing the bowels is solved, the function of the digestive tract is recovered, and the difficult problem is solved fundamentally.

The traditional Chinese medicine formula theoretically requires monarch, minister, assistant and guide, and the balance is essential. In the composition, the monarch drug is glossy privet fruit and seaweed, the ministerial drug is cistanche, the adjuvant drug is immature bitter orange and bighead atractylodes rhizome, and the conductant drug is angelica. Can be used for balancing yin and yang.

1. Immature bitter orange: the traditional Chinese medicines for regulating qi and promoting qi circulation have bidirectional regulating effect on gastrointestinal and anal sphincters, restore normal gastrointestinal motility, drain smoothly and reduce reflux. Can restore the function of the anal sphincter to normal relaxation and contraction, overcome the abnormal contraction of the anal sphincter during defecation and treat outlet obstruction type functional constipation.

2. White atractylodes rhizome: the spleen-tonifying and yang-invigorating functions, the gastrointestinal function power recovery, the normal digestion and absorption functions, the diuresis promoting, the moderate water content and the shaping of the excrement, and the prevention of the thin excrement and the watery excrement.

3. Cistanche deserticola: warm kidney yang, moisten intestine to relieve constipation, improve physique.

4. Glossy privet fruit: nourishing spleen and kidney yin, ensuring sufficient intestinal juice, changing stool quality from hard dry particles into soft stool with easy molding and smooth surface, and being capable of being smoothly discharged out of the body through the tubular cavity of intestinal tract and anus.

5. Chinese angelica: has effects of nourishing blood, promoting blood circulation, rich folic acid, vitamins, trace elements, and cellulose, improving blood circulation of human body and intestinal wall, and restoring gastrointestinal motility. Maintain the volume of excrement and urine, stimulate the peristalsis of the intestine and start the defecation.

6. Seaweed: the traditional habit of softening and resolving hard mass is commonly used for treating body surface nodules, is rarely used for treating constipation, is rich in cellulose, has smooth property, can increase the weight and volume of excrement, increase the humidity of the excrement, avoid the formation of dry and hard excrement blocks, stimulate the intestinal tract to wriggle and recover the defecation consciousness. Promoting defecation.

In order to retain medicinal material residues, increase the volume of excrement and facilitate taking, the invention adopts the preparation technology of water pills. The finished pill contains medicinal material residues, and has small volume and convenient administration.

A watered pill, also called watered pill, is a small round spherical solid pill prepared from Chinese medicinal materials fine powder with cold boiled water or medicinal liquid or other liquid as binder. The pill is prepared by preparing all the medicinal material fine powder in the prescription into pills by a preparation method, has small volume and compact and smooth surface, is convenient to swallow, is not easy to absorb moisture, and is favorable for storage and carrying.

Common adhesives include water, wine, vinegar, rice paste, medicinal liquid, etc. The adhesive used by the traditional Chinese medicine composition is cold boiled water after being boiled fresh.

The water has no viscosity, but can moisten and dissolve mucilage, starch, colloid and the like in the medicinal materials, and generate viscosity after moistening, so that pills can be prepared, and the mechanism is the same as that of the common water used as an adhesive for glue balls, steamed buns and noodles. The adhesive is water-soluble, and the solid pill is easy to disintegrate and absorb after being taken, and has quick action.

In order to make the surface of the prepared pill fine and smooth and easy to swallow, the crushing fineness of all the medicinal materials should be 120 meshes. Avoid the stimulation of the fiber hair on the surface of the prepared pill to the throat due to the thick medicinal powder.

The pills prepared by the composition are plain pills, namely without coatings, and the appearance is the mixed color of the raw medicinal materials. The size is the size of mung bean grains, and each 10 g of mung bean grains is 210-230 grains.

The preparation of water pill is that people firstly get inspiration (actually the surface tension of water bead) in the natural phenomenon of 'rain drops fall into dust and naturally form bead-shaped dust ball', when the water pill is manually prepared, a proper amount of medicinal powder is firstly placed in a bamboo dustpan, then a clean brush is used for dipping cold boiled water, the medicinal powder is sprinkled on the medicinal powder to form small medicinal powder beads (commonly called 'nut') which are shaken on a horizontal plane to shake the dustpan, so that the medicinal powder beads (nut) roll in the dustpan, and the medicinal powder is continuously adhered to the dustpan, the pills with bean particle size and uniform particles are formed like the snow ball, then the pills are poured into another dustpan, and the dustpan is tiled, dried or dried in the sun, and can not be piled up and adhered. Because the water content of the mother and the son is small, the powder which can be adhered is limited, and only small bean pills can be naturally formed, which just meets the size requirement and is convenient to take.

A preparation method of a traditional Chinese medicine composition (pill) for treating constipation comprises the following steps:

A. and (3) drying: weighing fructus Aurantii Immaturus, Atractylodis rhizoma, Cistanchis herba, fructus Ligustri Lucidi, radix Angelicae sinensis, and Sargassum at a certain ratio, respectively drying (microwave oven for about 2 minutes) to control water content within 5%.

B. Crushing: the immature bitter orange, the largehead atractylodes rhizome, the desertliving cistanche, the glossy privet fruit, the Chinese angelica and the seaweed are respectively crushed for 14 to 16 minutes each time and then sieved by a sieve with 110 meshes and 130 meshes. And crushing the raw materials passing through the sieve once again, sieving the crushed raw materials with a 110-plus-130-mesh sieve again, crushing the raw materials passing through the sieve once again, sieving the crushed raw materials with the 110-plus-130-mesh sieve again, and repeating the steps for 3-5 times, wherein the crushing and sieving of the raw materials can be basically achieved.

C. Mixing: mixing the pulverized fructus Aurantii Immaturus, Atractylodis rhizoma, Cistanchis herba, fructus Ligustri Lucidi, radix Angelicae sinensis, and Sargassum fine powder (120 mesh) uniformly to obtain mixture;

D. starting a mother and a son: and D, putting the medicinal powder of the mixture obtained in the step C into a bamboo dustpan, dipping the medicinal powder into fresh boiled cold water by using a clean brush, and spraying the medicinal powder onto the medicinal powder to form small medicinal powder beads.

E. Pill preparation: and D, placing the medicinal powder beads in the step D into a dustpan on a horizontal plane (next to the dustpan) and shaking the dustpan to enable the medicinal powder beads (mother and son) to roll in the dustpan and continuously stick medicinal powder, so that the pills with uniform bean particle size (common pills) and uniform particles are formed. Pouring the pills into another dustpan, spreading and drying or sun-drying, wherein the pills cannot be stacked and adhered, and storing the dried pills in a sealed manner.

Through the technical measures of the five steps: the most critical is B, D two steps:

step B emphasizes that the grinding fineness must pass through a sieve of 110-130 meshes, so that the prepared finished pills are fine, compact and smooth, do not irritate throats and are easy to take.

And D, starting the mother and the son, actually controlling the water content of the medicinal beads (mother and son), wherein the large water content is difficult to form a round bead shape, wastes raw materials, has large pill volume, is difficult to dry and is inconvenient to take. The special feature of pill preparation is lost. And C, dipping water in the brush until no water drops, and then spraying the mixture powder formed in the step C on the brush until small medicine beads are formed, and continuously horizontally rolling the medicine beads to continuously stick the medicine powder until no medicine powder sticks any more, so that the small medicine beads are formed.

Mainly solves the problems of rough surface, large granules, difficult taking and throat irritation of the pills. And (5) experimental observation. The common pills in the market are 6-9 g per pill, the taking is inconvenient, the extracted liquid dosage form is convenient, but the pill has the advantage that the volume and the weight of the excrement can be directly increased without medicine residues. The composition pill has 210-230 pills per 10 g, small volume, convenient taking and easy swallowing.

Because the medicine has small volume and takes water as an adhesive, the medicine is easy to disintegrate in the gastrointestinal tract, is fast to digest and absorb and has fast effect. Overcomes the problems of inconvenient swallowing of large-particle medicine, slow disintegration, difficult digestion and absorption and slow effect. Has relatively obvious technical progress and achieves the technical effects of convenient taking, easy swallowing and quick response.

Compared with the prior art, the invention has the following advantages and effects:

the traditional Chinese medicine composition (pill) for treating constipation has novel component selection, breaks through the traditional medication habit and thinking, does not contain rhubarb, fructus cannabis, bitter apricot seed, bunge cherry seed, betel nut and the like in terms of components, and avoids the toxic and side effects, drug resistance and dependence of the traditional medicine. It contains no honey, and is suitable for all people including diabetes.

The traditional Chinese medicine composition (compound) is the characteristics and advantages of traditional Chinese medicines in hundreds of years, can integrate multiple effects into a whole and plays the greatest role. The discovery and use of single or compound traditional Chinese medicines usually pay attention to the effect, focus on the clinic and indeed form a plurality of famous prescriptions and famous medicines. However, due to the limitations of the technological level and ability of the modern times, the chemical components contained in the medicinal materials cannot be known, some unsafe factors and toxic and side effects are often ignored, and the toxic and side effects of the composition containing single medicines such as rhubarb, bitter apricot seed, fructus cannabis, bunge cherry seed, betel nut, mirabilite and the like and the corresponding single medicines are analyzed.

The composition can recover gastrointestinal motility, improve the phenomenon that gastrointestinal motility is weak and inconvenient for people with slow-transit constipation, contains medicinal material residues, is rich in cellulose, can improve the feces, has proper weight, volume and humidity, can smoothly discharge formed soft feces without water discharge, and avoids iatrogenic (medicinal) anal stenosis caused by losing the expansion function of anus due to unformed feces. The soft excrement formed is easy to be discharged, does not stick to the anus skin and is easy to be wiped clean. Avoid pruritus ani peripheral skin caused by tiny skin injury caused by repeated wiping. Follow-up patients, feedback information is obtained: the excrement is easy to defecate, the notes are formed, the side effects of abdominal pain and diarrhea are avoided, and the excrement does not stick to a closestool and is easy to wash.

Because the traditional Chinese medicine composition does not contain the rhubarb in the first section, contains active ingredients of the rhubarb, does not contain mirabilite, almond, castor kernel, fructus cannabis, bunge cherry seed, betel nut and other medicines, avoids toxic and side effects, does not contain a large amount of tannic acid, does not cause constipation after diarrhea, and does not have the phenomenon of getting constipation after diarrhea. Has no side effect of abdominal pain and diarrhea, and has obvious advantages.

Detailed Description

Example 1:

a traditional Chinese medicine composition (watered pill) for treating constipation comprises the following raw materials in parts by weight:

a preparation method of a traditional Chinese medicine composition (pill) for treating constipation comprises the following steps:

A. and (3) drying: weighing 50 g of immature bitter orange, 25 g of largehead atractylodes rhizome, 50 g of desertliving cistanche, 50 g of glossy privet fruit, 25 g of Chinese angelica and 50 g of seaweed, respectively drying the materials, and controlling the water content within 5 percent in a microwave oven for 2 minutes.

B. Crushing: pulverizing fructus Aurantii Immaturus, Atractylodis rhizoma, Cistanchis herba, fructus Ligustri Lucidi, radix Angelicae sinensis, and Sargassum respectively for 14 or 15 or 16 minutes (grinding with small steel mill), and sieving with 110 or 120 or 130 mesh sieve. And (3) crushing the raw materials passing through the sieve once again, sieving the crushed raw materials by using a 110-120-130-mesh sieve, crushing the raw materials passing through the sieve once again, sieving the crushed raw materials by using the 110-120-130-mesh sieve again, and repeating the steps for 3, 4 or 5 times, so that the crushed and sieved raw materials can be basically completely obtained.

C. Mixing: mixing the pulverized fructus Aurantii Immaturus, Atractylodis rhizoma, Cistanchis herba, fructus Ligustri Lucidi, radix Angelicae sinensis, and Sargassum fine powder (120 mesh) uniformly to obtain mixture;

D. starting a mother and a son: and D, putting the medicinal powder of the mixture obtained in the step C into a bamboo dustpan, dipping the medicinal powder into fresh boiled cold water by using a clean brush, and spraying the medicinal powder onto the medicinal powder to form small medicinal powder beads.

E. Pill (composition): and D, placing the medicinal powder beads in the step D into a dustpan on a horizontal plane (next to the dustpan) and shaking the dustpan to enable the medicinal powder beads (starting up the mother and the son) to roll in the dustpan and continuously stick medicinal powder, so that the pills with uniform bean particle size (common pills) and uniform particles are formed. Pouring the pills into another dustpan, spreading and drying or sun-drying, wherein the pills cannot be stacked and adhered, and storing the dried pills in a sealed manner. Taking out the rest medicinal powder, rolling to obtain bean-sized pill, and sealing and storing the dried pill in food bag. Respectively weighing 10 g of pills, bagging with small sealed food bags, and storing in a refrigerator.

Mr. Yining is 83 years old, has a history of diabetes of 42 years, is accompanied by constipation and dry stool of 16 years, has little stool effect, and can relieve constipation by enema at ordinary times. The doctor visits the doctor in 6-month and 10-day 2020. By taking the following pills, the following effects are obtained. 10 g of pills (a small bag) are taken each time and taken twice a day with warm water. Taken in the morning and evening.

And returning to visit, discharging the head and the tail of the patient to form soft excrement in the evening on the next day after the patient takes the medicine, discharging the soft excrement to form soft excrement on the third day, and forming the soft excrement once every day later. Is easy to be discharged, and each time of defecation takes less than 5 minutes. No abdominal pain and diarrhea, easy cleaning of anus, no sticking of feces to toilet and easy cleaning. Ten days later, twice more amount of the above solution was taken for consolidation treatment.

Clinical observation in recent 10 years shows that strip-shaped cylindrical soft feces can be smoothly discharged on the next day or 3 days after administration, the defecation is easy, the defecation time is short, anus skin and a closestool are not pasted, and anus is easy to wipe and clean. No water sample, thin paste stool, granular dry hard stool, no abdominal pain and diarrhea. We randomly draw 46 parts of outpatient data between 5 months from 2019 to 2021: wherein 20 men and 26 women; the age is 18 years minimum, 83 years maximum, and 30-75 years maximum. More females than males. Of the 46 cases, 20 cases of simple chronic constipation (11 cases of slow transit constipation, 6 cases of outlet obstruction, and 3 cases of mixed type). IBS constipation type 2 cases. The medicine is accompanied by 3 cases of anal sinusitis, 10 cases of anal fissure, 3 cases of hemorrhoids, 2 cases of postpartum women, 3 cases of anus postoperation, 2 cases of diabetes and 1 case of constipation caused by side effect of the medicine.

The curative effect standard is as follows: defecation was maintained as "effective" within 24 hours of administration. The medicine is used for defecation within 36 hours, and the defecation is kept to be effective every day. Defecation is ineffective after more than 36 hours of administration.

In this set of data 46, 31 cases are valid, 12 cases are valid, and 3 cases are invalid. The total effective rate is 93.4%.

Example 2:

a traditional Chinese medicine composition (pill) for treating constipation comprises the following raw materials in parts by weight:

the procedure was the same as in example 1.

Wangning, male, 24 years old, pain in anus defecation, hematochezia, dry stool and unsmooth defecation for half a year, and the doctor can see the disease 9, 13 days in 2020. The diagnosis is anal fissure and constipation. The following effects are achieved after the medicine is taken: the pill is taken twice a day, in the morning and evening, 10 g each time. Defecation in 15 am (within 24 hours after pill taking) is finished, the soft stool is formed, the dryness is avoided, the pain is obviously relieved during defecation, and the bloody stool is avoided. After 20 days, the examination is repeated, the pain of the anus disappears, and the anal fissure ulcer surface is healed. Defecation is carried out once a day, the defecation time is less than 3 minutes, and no excrement blood exists.

Example 3:

a traditional Chinese medicine composition (pill) for treating constipation comprises the following raw materials in parts by weight:

the procedure was the same as in example 1.

A woman 43 years old in a week has no defecation at ordinary times, and has stools for 1-2 times per week for more than 5 years. Normal mental state and appetite, no abdominal distension and pain. Constipation was diagnosed as slow transit constipation. Enteroscopy and abdominal CT examination were performed to remove tumors.

The pill is taken twice a day, in the morning and evening, 10 g each time. The pill can be used for treating constipation in the morning 3 days, with urgent defecation, and soft stool with no dryness. And rechecking after 20 days. Defecation is performed once every day with the defecation requirement, and the defecation time is less than 3 minutes.

Example 4:

a traditional Chinese medicine composition (pill) for treating constipation comprises the following raw materials in parts by weight:

the procedure was the same as in example 1.

Mr. Yining, 56 years old, surgeon. The defecation feeling is weak at ordinary times, and the patient often cannot defecate in time when defecation is happier due to taking part in the operation. Defecating is not smooth, and the defecation is incomplete and the feeling of falling and swelling is caused. Enteroscopy excluded tumors. Prostate normal size. It is chronic habitual constipation.

The pill is taken twice a day, in the morning and evening, 10 g each time. The pill can be used for defecation at night next day, and has the advantages of soft and dry anus, easy cleaning of anus, and no feeling of fullness and distention in anus. And rechecking after 20 days. Defecation is performed once every day with the defecation requirement, and the defecation time is less than 3 minutes. The pill is prepared according to the amount of 2 times of the original traditional Chinese medicine composition, is still taken twice a day, 10 g for one time, and is taken with warm boiled water for consolidation treatment.

Example 5:

a traditional Chinese medicine composition (pill) for treating constipation comprises the following raw materials in parts by weight:

the procedure was the same as in example 1.

Mr. 57, constipation and diarrhea alternate for more than 20 years, abdominal pain occurs during diarrhea, abdominal pain disappears after defecation, dry stool occurs during constipation, the defecation is not smooth, mucus is attached to the surface of the stool, the stool is not completely defecated and falls and expands, hemorrhoids are sometimes separated, manual manipulation is required to be carried, the anus is not easy to wipe clean, the feces are sticky to the toilet, the obvious wall hanging phenomenon occurs, and the toilet is not easy to wash clean. Enteroscopy excluded tumors, diagnosed as: irritable bowel syndrome "IBS". The pill is taken twice a day, in the morning and evening, 10 g each time. The pill is used for defecation at night next day, is soft to form, is not dry, has defecation time less than 1 minute, is easy to clean, and has no swelling due to falling. Defecation is carried out once every morning, and the examination is carried out after 20 days, so that the defecation time is short, and no hemorrhoid is released. The anus is easy to wipe, and the excrement does not stick to the closestool and is easy to wash. Continuously preparing pills with twice of the traditional Chinese medicine composition for consolidation treatment.

The invention relates to a traditional Chinese medicine composition (pill) for treating constipation, which has novel component selection, breaks through the traditional medication habit and thinking, and comprises immature bitter orange, largehead atractylodes rhizome, desertliving cistanche, glossy privet fruit, Chinese angelica, seaweed and drinking water. Free (not selected): fructus cannabis, bitter apricot seed, bunge cherry seed, castor bean, sulfur, betel nut, mirabilite, rhubarb (medicinal materials with similar components to rhubarb: folium sennae, polygonum multiflorum, aloe, tuber fleeceflower stem, rumex japonicus (rumex japonicus), polygonum cuspidatum, sauropus, snakegourd fruit and the like), so that the toxic and side effects, such as abdominal pain and diarrhea, as well as drug resistance and dependence of the traditional medicines are avoided.

The preparation method adopts a generic preparation method, uses the original medicinal materials for direct processing, has no additive or extraction process, retains medicinal material residues and cellulose, and has small volume, smoothness, compactness and convenient taking of finished pills. Can directly increase the volume of the excrement, start the defecation and is beneficial to defecation.

The binder used in the preparation is common drinking water, contains no honey, and is suitable for all people including diabetes.

In a word, the invention belongs to the technical field of traditional Chinese medicine pills for treating constipation, and more particularly relates to a traditional Chinese medicine composition (pill) for treating constipation, and a preparation method of the traditional Chinese medicine composition (pill) for treating constipation, wherein the traditional Chinese medicine composition (pill) has obvious technical effect superiority, and the clinical treatment effect reaches more than 90%. The traditional Chinese medicine composition has obvious effects of improving constipation, preventing cardiovascular events caused by constipation, treating hemorrhoids, anal fissure, anal sinusitis, anal injury, habitual constipation, inguinal hernia, puerperal constipation, postoperative constipation, constipation of long-term bedridden patients and the like related to constipation, can effectively relieve psychological and mental pressure caused by difficult defecation, and obviously improves the life quality.