阅读说明：本技术 一种缓释抗氧剂容器的材料及其制备方法 (Material of slow-release antioxidant container and preparation method thereof ) 是由 许燕 林帅 于 2021-08-27 设计创作，主要内容包括：本发明提供的一种缓释抗氧剂容器的材料,材料配方为主材料聚烯烃树脂,重量占比大于99.8％；助剂材料和氮气；其中助剂材料包括抗氧剂,重量占比不大于0.1％；合成水滑石,重量占比0.01-0.05％；着色剂,重量占比不大于0.1％；脂肪酸酯,重量比不大于0.1％。本发明提供的一种缓释抗氧剂容器的材料及其制备方法,通过在容器主材料中增加助剂,将其中的抗氧剂在药剂溶液中进行缓释,从而使药剂溶液内的抗氧剂达标,不仅保证了药剂的保质期,而且防止制药过程中增加抗氧剂而造成的药剂失效和变化,提高药剂保存质量。(The material formula of the slow-release antioxidant container provided by the invention is polyolefin resin which is a main material, and the weight ratio is more than 99.8%; an auxiliary material and nitrogen; wherein the auxiliary material comprises an antioxidant, and the weight ratio is not more than 0.1%; synthetic hydrotalcite, the weight percentage is 0.01-0.05%; a colorant in an amount of not more than 0.1% by weight; fatty acid ester, the weight ratio is not more than 0.1%. According to the material of the slow-release antioxidant container and the preparation method thereof, the auxiliary agent is added into the main material of the container, and the antioxidant in the container is slowly released in the medicament solution, so that the antioxidant in the medicament solution reaches the standard, the quality guarantee period of the medicament is ensured, the medicament failure and change caused by the addition of the antioxidant in the pharmaceutical process are prevented, and the medicament storage quality is improved.)

1. The material of the slow-release antioxidant container is characterized in that the material formula is polyolefin resin which is a main material, and the weight ratio is more than 99.8 percent; an auxiliary material and nitrogen; wherein the auxiliary material comprises an antioxidant, and the weight ratio is not more than 0.1%; synthetic hydrotalcite, the weight percentage is 0.01-0.05%; a colorant in an amount of not more than 0.1% by weight; fatty acid ester, the weight ratio is not more than 0.1%.

2. The material for the slow-release antioxidant container as in claim 1, wherein the antioxidant is 2, 6-di-tert-butyl-4-methylphenol.

3. The material for a container for slow-release antioxidants of claim 1, wherein said synthetic hydrotalcite is basic aluminum iron carbonate.

4. The material for the slow-release antioxidant container as claimed in claim 1, wherein the preparation method comprises the steps of firstly melting the polyolefin resin at a high temperature, secondly adding the auxiliary material into the main material, mixing and stirring, continuously introducing nitrogen, and finally shaping and cooling to complete the preparation.

5. The material for sustained-release antioxidant containers as claimed in claim 4, wherein the high temperature melting temperature is 155-210 ℃.

6. The slow-release antioxidant container material as claimed in claim 4, wherein the nitrogen flow rate is 0.2M³/H。

Technical Field

The invention relates to a material of a slow-release antioxidant container and a preparation method thereof.

Background

The medical medicament needs to utilize an antioxidant to improve the storage time of the medicament, but chemical components in the medicament are different, the antioxidant can be quickly volatilized in the medicament and cannot reach the required proportion, so that the finished medicament cannot have a determined quality guarantee period, and the use of a user is influenced.

The conventional food antioxidant employs 2, 6-di-tert-butyl-4-methylphenol (BHT) as an antioxidant, which reacts with chain-propagating radicals in autoxidation to destroy the radicals, thereby interrupting the chain reaction. 2, 6-di-tert-butyl-4-methylphenol (BHT) can be used as a hydrogen donor and a free radical trapping agent in an antioxidation process. 2, 6-di-tert-butyl-4-methylphenol (BHT) has a strong antioxidant effect because 2 strong electron-donating groups are arranged on 2,6 positions.

However, in the preparation process of the medicament, a plurality of compounds are required to be mixed, the internal composition is complex, the overall dispensing ratio is affected once the antioxidant is added, and the medicament is seriously deteriorated, so that a plurality of medicaments can be only temporarily dispensed or used for a short time, the storage and the transportation of the medicaments are inconvenient, and the use of the medicaments is affected.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: the material of the slow-release antioxidant container and the preparation method thereof are provided, aiming at increasing the antioxidant in the traditional medicament bottle material, realizing the dose balance in the medicament by slowly releasing the antioxidant into the medicament by utilizing the slow-release characteristic and providing a guarantee for the antioxidant preservation of the medicament.

In order to solve the technical problems, the technical scheme of the invention is as follows: the material formula of the slow-release antioxidant container is polyolefin resin which is a main material, and the weight ratio is more than 99.8 percent; an auxiliary material and nitrogen; wherein the auxiliary material comprises an antioxidant, and the weight ratio is not more than 0.1%; synthetic hydrotalcite, the weight percentage is 0.01-0.05%; a colorant in an amount of not more than 0.1% by weight; fatty acid ester, the weight ratio is not more than 0.1%.

Further, the antioxidant is 2, 6-di-tert-butyl-4-methylphenol.

Further, the synthetic hydrotalcite is basic aluminum iron carbonate.

Further, a preparation method of the slow-release antioxidant container comprises the steps of firstly melting the polyolefin resin at high temperature, secondly adding the auxiliary material into the main material, mixing and stirring, continuously inputting nitrogen, and finally shaping and cooling to finish the preparation.

Further, the high temperature melting temperature is 155-.

Further, the nitrogen flow rate is 0.2M³/H。

Compared with the prior art, the material of the slow-release antioxidant container and the preparation method thereof provided by the invention have the advantages that the auxiliary agent is added into the main material of the container, and the antioxidant in the container is slowly released in the medicament solution, so that the antioxidant in the medicament solution reaches the standard, the quality guarantee period of the medicament is ensured, the medicament failure and change caused by the addition of the antioxidant in the pharmaceutical process are prevented, and the medicament storage quality is improved.

Detailed Description

The material formula of the slow-release antioxidant container is polyolefin resin which is a main material, and the weight ratio is more than 99.8 percent; an auxiliary material and nitrogen; wherein the auxiliary material comprises an antioxidant, and the weight ratio is not more than 0.1%; synthetic hydrotalcite, the weight percentage is 0.01-0.05%; a colorant in an amount of not more than 0.1% by weight; fatty acid ester, the weight ratio is not more than 0.1%.

Further, the antioxidant is 2, 6-di-tert-butyl-4-methylphenol.

Further, the synthetic hydrotalcite is basic aluminum iron carbonate.

Further, a preparation method of the slow-release antioxidant container comprises the steps of firstly melting the polyolefin resin at high temperature, secondly adding the auxiliary material into the main material, mixing and stirring, continuously inputting nitrogen, and finally shaping and cooling to finish the preparation.

Further, the high temperature melting temperature is 155-.

Further, the nitrogen flow rate is 0.2M³/H。。

Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the technical solutions, and those skilled in the art should understand that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions, and all the modifications and equivalent substitutions should be covered by the claims of the present invention.