阅读说明：本技术 血浆吸附透析滤过装置和血浆置换系统 (Plasma adsorption dialysis filtering device and plasma replacement system ) 是由 田沂 蒋永芳 李异 周宁 彭锋 于 2021-10-12 设计创作，主要内容包括：本发明公开了一种血浆吸附透析滤过装置和血浆置换系统,血浆吸附透析滤过装置包括：血滤器,和血滤器连通的血浆输送管路,均设置于血浆输送管路的输入泵和吸附器,用于向血滤器输入透析液的透析液输入管路,用于向血滤器输入滤液的滤液输入管路,用于将血滤器内的废液输出的废液输出管路,血浆输出管路和循环透析管路；其中,血浆输出管路用于将血滤器透析滤过的净化血浆输出,循环透析管路用于将血滤器透析滤过的净化血浆返回至血滤器内。血浆吸附透析滤过装置既能实现低速分离血浆进行血浆吸附的安全性,也能实现高速血浆透析滤过清除水溶性毒素的高效率性。血浆吸附透析滤过装置和血浆置换系统既能实现离心式血浆置换,也能实现膜式血液净化。(The invention discloses a plasma adsorption dialysis filter device and a plasma replacement system, wherein the plasma adsorption dialysis filter device comprises: the blood filter, the plasma conveying pipeline communicated with the blood filter, the input pump and the adsorber which are arranged on the plasma conveying pipeline, the dialysate input pipeline used for inputting dialysate into the blood filter, the filtrate input pipeline used for inputting filtrate into the blood filter, the waste liquid output pipeline used for outputting waste liquid in the blood filter, the plasma output pipeline and the circulating dialysis pipeline; the plasma output pipeline is used for outputting purified plasma dialyzed and filtered by the blood filter, and the circulating dialysis pipeline is used for returning the purified plasma dialyzed and filtered by the blood filter to the blood filter. The plasma adsorption dialysis filtering device can realize the safety of plasma adsorption by low-speed plasma separation and can also realize the high efficiency of removing water-soluble toxin by high-speed plasma dialysis filtering. The plasma adsorption dialysis filtering device and the plasma exchange system can realize centrifugal plasma exchange and membrane type blood purification.)

1. A plasma adsorption diafiltration device comprising: a plasma conveying pipeline (21), an input pump (210) and an adsorber which are all arranged on the plasma conveying pipeline (21), a blood filter (213), a dialysate input pipeline (22), a filtrate input pipeline (24), a waste liquid output pipeline (23), a plasma output pipeline (25) and a circulating dialysis pipeline (26);

wherein the plasma delivery line (21) is in communication with the blood filter (213), the blood filter (213) being for diafiltration of plasma;

the dialysate input line (22) is configured to input dialysate to the blood filter (213), the filtrate input line (24) is configured to input filtrate to the blood filter (213), the waste fluid output line (23) is configured to output waste fluid in the blood filter (213), the plasma output line (25) is configured to output purified plasma diafiltered by the blood filter (213), and the circulating dialysis line (26) is configured to return purified plasma diafiltered by the blood filter (213) to the blood filter (213).

2. The plasma adsorption diafiltration device according to claim 1,

the adsorber is located upstream of the input pump (210);

the circulating dialysis line (26) is communicated with the plasma conveying line (21), and the communication position of the circulating dialysis line (26) and the plasma conveying line (21) is positioned between the input pump (210) and the adsorber;

the filtrate input pipeline (24) is communicated with the plasma conveying pipeline (21), and the communication position of the filtrate input pipeline (24) and the plasma conveying pipeline (21) is positioned between the input pump (210) and the adsorber.

3. The plasma adsorption diafiltration device according to claim 1, characterized in that the plasma output line (25) is provided with a first three-way valve (251), the circulating dialysis line (26) communicating with the plasma output line (25) through the first three-way valve (251);

wherein, if the first three-way valve (251) is in a first valve position, only the circulating dialysis line (26) and the blood filter (213) are in communication; if the first three-way valve (251) is in the second valve position, the circulating dialysis line (26) and the plasma output line (25) are both in communication with the blood filter (213).

4. The plasma adsorption diafiltration device according to claim 1, further comprising: a dialysate pump (220) arranged in the dialysate input line (22), a filtrate pump (240) arranged in the filtrate input line (24), and a waste liquid pump (230) arranged in the waste liquid output line (23);

the pump speed of the input pump (210) is 100-200 ml/min, the pump speed of the dialysate pump (220) is 50-60 ml/min, the pump speed of the filtrate pump (240) is 50-60 ml/min, and the pump speed of the waste liquid pump (230) is 100-120 ml/min.

5. The plasma adsorption diafiltration device according to claim 1, further comprising: the filter liquor storage device (241) is communicated with the filtrate input pipeline (24), the dialysate storage device (221) is communicated with the dialysate input pipeline (22), the waste liquor storage device (231) is communicated with the waste liquor output pipeline (23), the first liquor pot (243) and the first heating device (242) are sequentially arranged on the filtrate input pipeline (24), and the second liquor pot (223) and the second heating device (222) are sequentially arranged on the dialysate input pipeline (22).

6. The plasma adsorption diafiltration device according to any of claims 1-5, wherein there are at least two adsorbers, both located upstream of the input pump (210).

7. A plasmapheresis system, comprising: a blood separation device, a return device, and a plasma adsorption diafiltration device according to any one of claims 1 to 6;

wherein, the blood separation device can collect blood and separate out and collect plasma in the blood;

the plasma adsorption diafiltration device is used for adsorbing and dialyzing the plasma separated by the blood separation device;

the back-transfusion device is used for returning the purified plasma discharged by the plasma adsorption dialysis filtering device to the body.

8. The plasmapheresis system according to claim 7,

the blood separation device can also separate blood cells in blood;

the back-infusion device comprises a plasma reservoir (320) for storing fresh plasma, and the back-infusion device is further capable of back-infusing the fresh plasma in the plasma reservoir (320) and the blood cells separated by the blood separation device into the body.

9. The plasmapheresis system of claim 8, wherein the blood separation device comprises: a blood collection pipeline (11), a centrifugal separation device (12), a blood cell output pipeline (14), a plasma output pipeline (13) and a plasma collector (131);

wherein the blood collection pipeline (11) is used for inputting blood to the centrifugal separation device (12), and the blood collection pipeline (11) is provided with a blood collection pump (110);

the blood cell output pipeline (14) is communicated with the centrifugal separation device (12) and the back infusion device;

the plasma output pipeline (13) is communicated with the centrifugal separation device (12) and the plasma collector (131), a plasma collection pump (130) is arranged on the plasma output pipeline (13), the plasma conveying pipeline (21) can be communicated with the plasma output pipeline (13), and the communication position of the plasma conveying pipeline (21) and the plasma output pipeline (13) is positioned at the downstream of the plasma collection pump (130);

the plasma delivery line (21) is communicated with the plasma output line (13) through a second three-way valve (132), and if the second three-way valve (132) is at a first valve position, the plasma output line (13) is communicated with the centrifugal separation device and the plasma collector (131); if the second three-way valve (132) is at the second valve position, the plasma output line (13) is communicated with the plasma conveying line (21).

10. The plasmapheresis system of claim 8, wherein the reinfusion device comprises: a plasma return line (32), a plasma return pump (322) disposed on the plasma return line (32), a blood return line (31), and a blood return pump (310) disposed on the blood return line (31);

wherein the plasma output line (25) and the plasma reservoir (320) are both in communication with the plasma return line (32), and the blood cell output line (14) and the plasma return line (32) of the blood separation device are both in communication with the blood return line (31).

Technical Field

The invention relates to the technical field of blood purification, in particular to a plasma adsorption dialysis filtering device and a plasma replacement system.

Background

Acute liver failure or chronic acute liver failure accompanied by cytokine storm and over-activation of cytotoxic T lymphocytes continuously damages hepatocytes, blood coagulation dysfunction, severe and rapid disease progress, and is easy to cause multiple organ failure, and the life is threatened if the disease progress cannot be prevented in a short period. Since the 21 st century, SARS and people infected with highly pathogenic avian influenza, novel coronavirus pneumonia (COVID-19), sepsis and other new infectious diseases accompanied with high cytokine storm seriously threaten the life safety of human beings.

Currently, artificial liver is a blood purification method for treating liver failure and also can be cleared against cytokine storm. The existing blood purification methods are all used for purifying blood plasma, and focus on improving the efficiency of blood plasma purification. Aiming at protein-bound toxin, plasma exchange and plasma adsorption are mainly adopted, the requirement on the plasma separation speed is low, and the treatment requirement can be met by 25-30 ml/min. Aiming at water-soluble toxins, hemodialysis and hemofiltration exist, the requirement on the flow rate of blood plasma is high, under the existing condition, the treatment requirement is often met by improving the flow rate of blood passing through a filter, so that deep vein catheterization or arteriovenous fistulization is required to ensure the smooth proceeding of treatment, and the risks of bleeding and infection at the position of catheterization are increased. Limits the clinical popularization and application of the traditional Chinese medicine composition in patients with blood coagulation dysfunction.

In summary, how to effectively integrate the plasma purification method to improve the plasma purification efficiency is an urgent problem to be solved by those skilled in the art.

Disclosure of Invention

The invention aims to provide a plasma adsorption dialysis filtering device to improve the efficiency of plasma purification. Another object of the present invention is to provide a plasmapheresis system comprising the above plasmapheresis diafiltration device.

In order to achieve the above purpose, the invention provides the following technical scheme:

a plasma adsorption diafiltration device comprising: the plasma conveying pipeline is arranged on an input pump and an absorber of the plasma conveying pipeline, and comprises a blood filter, a dialysate input pipeline, a filtrate input pipeline, a waste liquid output pipeline, a plasma output pipeline and a circulating dialysis pipeline;

wherein the plasma conveying pipeline is communicated with the blood filter, and the blood filter is used for performing dialysis filtration on plasma;

the dialysate input pipeline is used for inputting dialysate into the blood filter, the filtrate input pipeline is used for inputting filtrate into the blood filter, the waste liquid output pipeline is used for outputting waste liquid in the blood filter, the plasma output pipeline is used for outputting purified plasma dialyzed and filtered by the blood filter, and the circulating dialysis pipeline is used for returning the purified plasma dialyzed and filtered by the blood filter to the blood filter.

Optionally, the adsorber is located upstream of the input pump;

the circulating dialysis pipeline is communicated with the plasma conveying pipeline, and the communication position of the circulating dialysis pipeline and the plasma conveying pipeline is positioned between the input pump and the adsorber;

the filtrate input pipeline is communicated with the plasma conveying pipeline, and the communication position of the filtrate input pipeline and the plasma conveying pipeline is positioned between the input pump and the adsorber.

Optionally, the plasma output line is provided with a first three-way valve, and the circulating dialysis line is communicated with the plasma output line through the first three-way valve;

wherein, if the first three-way valve is in the first valve position, only the circulating dialysis line is communicated with the blood filter; if the first three-way valve is in the second valve position, the circulating dialysis pipeline and the plasma output pipeline are both communicated with the blood filter.

Optionally, the plasma adsorption diafiltration device further comprises: the dialysate pump is arranged on the dialysate input pipeline, the filtrate pump is arranged on the filtrate input pipeline, and the waste liquid pump is arranged on the waste liquid output pipeline;

the pump speed of the input pump is 100-200 ml/min, the pump speed of the dialysate pump is 50-60 ml/min, the pump speed of the filtrate pump is 50-60 ml/min, and the pump speed of the waste liquid pump is 100-120 ml/min.

Optionally, the plasma adsorption diafiltration device further comprises: the filter comprises a filtrate storage device communicated with a filtrate input pipeline, a dialysate storage device communicated with a dialysate input pipeline, a waste liquid storage device communicated with a waste liquid output pipeline, a first liquid pot and a first heating device which are sequentially arranged on the filtrate input pipeline, and a second liquid pot and a second heating device which are sequentially arranged on the dialysate input pipeline.

Optionally, the number of adsorbers is at least two and each is located upstream of the input pump.

The plasma adsorption dialysis filtering device provided by the invention has the advantages that the plasma discharged by the blood filter is returned to the blood filter for secondary dialysis filtering by arranging the circulating dialysis pipeline, the requirement of high-speed dialysis filtering on the plasma flow rate can be met, and high-speed dialysis filtering in the blood filter can be realized under the condition of low-speed adsorption in the adsorber. Therefore, the plasma adsorption dialysis filtering device not only realizes the safety of plasma adsorption by low-speed plasma separation, but also realizes the high efficiency of removing water-soluble toxin by high-speed plasma dialysis filtering, and fully exerts the treatment advantages of various plasma purification means, thereby improving the efficiency of plasma purification.

Based on the plasma adsorption diafiltration device provided above, the present invention also provides a plasma exchange system, which includes: a blood separation device, a return device, and any one of the above plasma adsorption diafiltration devices;

wherein, the blood separation device can collect blood and separate out and collect plasma in the blood;

the plasma adsorption diafiltration device is used for adsorbing and dialyzing the plasma separated by the blood separation device;

the back-transfusion device is used for returning the purified plasma discharged by the plasma adsorption dialysis filtering device to the body.

The blood separation device can separate blood cells in blood;

the back-infusion device comprises a plasma storage for storing fresh plasma, and the back-infusion device can also back-infuse the fresh plasma in the plasma storage and the blood cells separated by the blood separation device into the body.

Optionally, the blood separation device comprises: the blood collection device comprises a blood collection pipeline, a centrifugal separation device, a blood cell output pipeline, a plasma output pipeline and a plasma collector;

the blood collection pipeline is used for inputting blood to the centrifugal separation device and is provided with a blood collection pump;

the blood cell output pipeline is communicated with the centrifugal separation device and the feedback device;

the plasma output pipeline is communicated with the centrifugal separation device and the plasma collector, a plasma collection pump is arranged on the plasma output pipeline, the plasma conveying pipeline can be communicated with the plasma output pipeline, and the communication position of the plasma conveying pipeline and the plasma output pipeline is positioned at the downstream of the plasma collection pump;

the plasma conveying pipeline is communicated with the plasma output pipeline through a second three-way valve, and if the second three-way valve is positioned at a first valve position, the plasma output pipeline is communicated with the centrifugal separation device and the plasma collector; if the second three-way valve is in a second valve position, the plasma output pipeline is communicated with the plasma conveying pipeline.

Optionally, the feedback device comprises: the blood plasma feedback device comprises a blood plasma feedback pipeline, a blood plasma feedback pump arranged on the blood plasma feedback pipeline, a blood feedback pipeline and a blood feedback pump arranged on the blood feedback pipeline;

the blood cell output pipeline and the blood plasma return pipeline of the blood separation device are communicated with the blood return pipeline.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a plasma adsorption diafiltration device and a plasma exchange system according to an embodiment of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

As shown in fig. 1, a plasma adsorption diafiltration device provided by an embodiment of the present invention includes: the plasma transfer line 21 is provided with an input pump 210 and an adsorber of the plasma transfer line 21, a blood filter 213, a dialysate input line 22, a filtrate input line 24, a waste liquid output line 23, a plasma output line 25, and a circulating dialysis line 26.

The input pump 210 and the adsorbers are both arranged on the plasma conveying pipeline 21, and the adsorbers can be selected to be located at the upstream of the input pump 210, so that plasma firstly passes through the adsorbers and then passes through the input pump 210, and therefore, the adsorption efficiency can be improved, and the influence of impurities in the plasma on the input pump 210 can be avoided. Of course, the input pump 210 may alternatively be located upstream of the adsorber, and is not limited to the above limitations.

The plasma transfer line 21 communicates with a blood filter 213, and the blood filter 213 is used for hemodiafiltration of plasma; the dialysate input line 22 is used to input dialysate to the blood filter 213, the filtrate input line 24 is used to input filtrate to the blood filter 213, the waste liquid output line 23 is used to output waste liquid in the blood filter 213, the plasma output line 25 is used to output purified plasma dialyzed by the blood filter 213, and the circulating dialysis line 26 is used to return the purified plasma dialyzed by the blood filter 213 to the blood filter 213.

The working process of the plasma adsorption diafiltration device provided by the above embodiment is as follows: under the action of the input pump 210, the plasma reaches the adsorber through the plasma conveying pipeline 21, the adsorber adsorbs bilirubin and other impurities in the plasma, the plasma passing through the adsorber enters the blood filter 213, meanwhile, the filtrate also enters the blood filter 213, the blood filter 213 carries out ultrafiltration on the plasma, and the purified plasma discharged by the blood filter 213 returns to the blood filter 213 through the circulating dialysis pipeline 26; after the completion of the diafiltration, the purified plasma discharged from the blood filter 213 is discharged through the plasma output line 25.

The plasma adsorption diafiltration apparatus according to the above-described embodiment realizes return of the purified plasma discharged from the blood filter 213 to the blood filter 213 for further diafiltration by providing the circulating dialysis line 26, and can satisfy the demand for the plasma flow rate in the high-speed diafiltration, and can realize high-speed diafiltration in the blood filter 213 by low-speed adsorption in the adsorber. Therefore, the plasma adsorption dialysis filtering device not only realizes the safety of plasma adsorption by low-speed plasma separation, but also realizes the high efficiency of removing water-soluble toxin by high-speed plasma dialysis filtering, and fully exerts the treatment advantages of various plasma purification means, thereby improving the efficiency of plasma purification, reducing the adverse reaction and the worry of stem cell transplantation, and effectively popularizing the stem cell transplantation.

In the plasma adsorption diafiltration apparatus, the circulating dialysis line 26 is used to return the purified plasma dialyzed and filtered by the blood filter 213 to the blood filter 213. In order to control the diafiltration effect, the circulating dialysis line 26 is connected to the plasma delivery line 21, and the position of the circulating dialysis line 26 connected to the plasma delivery line 21 is located between the input pump 210 and the adsorber.

Accordingly, the filtrate inlet line 24 is in communication with the plasma delivery line 21, and the location of the communication between the filtrate inlet line 24 and the plasma delivery line 21 is between the inlet pump 210 and the adsorber.

Specifically, the communication position between the circulating dialysis line 26 and the plasma transport line 21 and the communication position between the filtrate input line 24 and the plasma transport line 21 may be the same position on the plasma transport line 21 or different positions on the plasma transport line 21, and may be selected according to actual needs.

In the operation of the plasma adsorption diafiltration apparatus, the connection state between the circulating dialysis line 26 and the blood filter 213 and the connection state between the plasma discharge line 25 and the blood filter 213 are changed. In order to meet the required connection condition, the plasma discharge line 25 is provided with a first three-way valve 251, and the circulating dialysis line 26 is communicated with the plasma discharge line 25 through the first three-way valve 251. If the first three-way valve 251 is in the first valve position, only the circulating dialysis line 26 and the blood filter 213 are communicated; if the first three-way valve 251 is in the second valve position, the circulating dialysis line 26 and the plasma output line 25 are both in communication with the blood filter 213.

Of course, the first three-way valve 251 may be provided in the circulating dialysis line 26 by directly connecting the circulating dialysis line 26 to the blood filter 213; alternatively, the plasma discharge line 25 may be provided with an on-off valve, and the circulating dialysis line 26 may be provided with an on-off valve, but the present invention is not limited to the above embodiment.

In order to facilitate the control of the diafiltration of the plasma, the plasma adsorption diafiltration device further comprises: a dialysate pump 220 provided in the dialysate input line 22, a filtrate pump 240 provided in the filtrate input line 24, and a waste liquid pump 230 provided in the waste liquid output line 23.

No ultrafiltration occurs when the pump speed of the waste pump 230 equals the sum of the pump speeds of the filtrate pump 240 and the dialysate pump 220; when the pump speed of the waste liquid pump 230 exceeds the sum of the pump speeds of the filtrate pump 240 and the dialysate pump 220, the ultrafiltration is performed, and the difference between the pump speed of the waste liquid pump 230 and the sum of the pump speeds of the filtrate pump 240 and the dialysate pump 220 is the ultrafiltration speed, which is generally not more than 5 ml/min.

In practical application, the pump speed of the input pump 210 is selected to be 100-200 ml/min, the pump speed of the dialysate pump 220 is selected to be 50-60 ml/min, the pump speed of the filtrate pump 240 is selected to be 50-60 ml/min, and the pump speed of the waste liquid pump 230 is selected to be 100-120 ml/min. Further, the pumping speed of the input pump 210 is 150 to 200 ml/min. Of course, the pump speed of the input pump 210, the pump speed of the dialysate pump 220, the pump speed of the filtrate pump 240, and the pump speed of the waste liquid pump 230 may be selected from other types, and are not limited to the above.

In order to facilitate the supply of the filtrate, the plasma adsorption diafiltration device further comprises a filtrate storage device 241 in communication with the filtrate input line 24.

In order to prevent air bubbles in the filtrate from entering the blood filter 213 and to ensure the temperature of the filtrate, the plasma adsorption diafiltration device further includes a first solution pot 243 and a first heating device 242 sequentially disposed on the filtrate input line 24. Wherein the first pot 243 is close to the filtrate storage device 241, and the first heating device 242 is close to the filtrate pump 240.

The types of the filtrate storage device 241, the first kettle 243 and the first heating device 242 are selected according to actual needs, and this embodiment is not limited thereto.

Accordingly, in order to facilitate collection of the waste liquid and supply of the dialysate, the plasma adsorption diafiltration device further comprises a waste liquid storage device 231 in communication with the waste liquid output line 23, and a dialysate storage device 221 in communication with the dialysate input line 22.

In order to prevent air bubbles in the dialysate from entering the blood filter 213 and to ensure the temperature of the dialysate, the plasma adsorption diafiltration apparatus further includes a second liquid bottle 223 and a second heating device 222 which are sequentially disposed on the dialysate input line 22. Wherein the second fluid jug 223 is proximate to the dialysate storage device 221 and the second heating device 222 is proximate to the dialysate pump 220.

The types of the waste liquid storage device 231, the dialysate storage device 221, the second liquid pot 223 and the second heating device 222 are selected according to actual needs, and the present embodiment is not limited thereto.

For convenience of use, the filtrate storage device 241 is a filtrate bag, the dialysate storage device 221 is a dialysate bag, the waste liquid storage device 231 is a waste liquid bag, and the filtrate bag, the dialysate bag and the waste liquid bag are all hung on a scale hook to monitor the weight. The scale hook is not shown in fig. 1.

In the plasma adsorption diafiltration device, the specific type of the blood filter 213 is selected according to actual needs, but this embodiment is not limited thereto.

Specifically, the blood filter 213 has a plasma inlet, a dialysate inlet, a waste liquid outlet, and a plasma outlet. For the convenience of diafiltration, the plasma inlet is located at the top of the blood filter 213, the waste outlet is higher than the dialysate inlet, and the plasma outlet is located at the bottom of the blood filter 213.

It will be appreciated that the plasma delivery line 21 communicates with the plasma inlet, the dialysate inlet line 22 communicates with the dialysate inlet, the waste fluid outlet line 23 communicates with the waste fluid outlet, and the plasma outlet line 25 and the circulating dialysis line 26 communicate with the plasma outlet. Along the height direction of the blood filter 213, a plasma inlet, a waste liquid outlet, a dialysate inlet, and a plasma outlet are sequentially distributed.

In the plasma adsorption diafiltration apparatus, in order to prevent plasma coagulation, the plasma transfer line 21 is provided with a first heparin pump 214, and the first heparin pump 214 is located upstream of the adsorber.

The number of adsorbers is selected according to actual needs. Specifically, the number of the adsorbers may be one, or two or more. In order to achieve multiple adsorbtions to improve the adsorption effect, at least two adsorbers are provided and are located upstream of the input pump 210.

The type of adsorber is chosen according to the actual need. For example, at least one of the adsorbers is a bilirubin adsorber, and at least one of the adsorbers 212 is a neutral resin adsorber or an activated carbon adsorber, but the present embodiment is not limited thereto.

Specifically, there are two adsorbers, namely a first adsorber 211 and a second adsorber 212; the first adsorber 211 is a bilirubin adsorber, and the second adsorber 212 is a neutral resin adsorber or an activated carbon adsorber. The first heparin pump 214, the first adsorber 211, the second adsorber 212 and the feed pump 210 are distributed in this order.

Based on the plasma adsorption diafiltration device provided in the above embodiment, the present embodiment further provides a plasmapheresis system, as shown in fig. 1, the plasmapheresis system includes a blood separation device, a feedback device, and the plasma adsorption diafiltration device described in the above embodiment.

The blood separation device can collect blood and separate and collect plasma in the blood; the plasma adsorption dialysis filtering device is used for adsorbing and dialyzing the plasma separated by the blood separating device, namely the plasma conveying pipeline 21 is communicated with the plasma separating device; the feedback device is used for feeding back the purified plasma discharged by the plasma adsorption dialysis filtering device into the body, namely the plasma output pipeline 25 is communicated with the feedback device.

According to the plasma replacement system, the blood is collected and separated through the blood separation device, plasma is obtained after separation, the plasma is adsorbed and dialyzed and filtered through the plasma adsorption and dialysis and filtration device, and the plasma after adsorption and dialysis and filtration is returned to the body through the return device, so that the purification and replacement of the plasma are realized.

Since the plasma adsorption diafiltration device provided by the above embodiment has the above technical effects, and the plasma exchange system includes the above plasma adsorption diafiltration device, the plasma exchange system also has corresponding technical effects, and details are not described herein.

In order to optimize the plasmapheresis system, the blood separation device can separate blood cells in blood; the feedback device comprises a plasma storage 320 for storing fresh plasma, and the feedback device can also feed back the fresh plasma in the plasma storage 320 and the blood cells separated by the blood separation device into the body. The fresh plasma refers to thawed fresh frozen plasma containing normal amount of all blood coagulation factors, i.e., FFP, and if necessary, the plasma replacement may be performed by partially replacing FFP with 4% to 5% albumin, wherein the amount of albumin does not exceed half of the total amount of plasma replacement.

Specifically, when plasma replacement is required, the blood cell separated by the blood separation device and the fresh plasma in the plasma reservoir 320 are returned to the body by the return device, and the separated waste plasma enters the plasma collector 131; when the fresh plasma in the plasma storage 320 is used up and plasma adsorption diafiltration is required sequentially, the separated waste plasma does not enter the plasma collector 131 any more, but enters the plasma adsorption diafiltration device to adsorb and diafilter the plasma, and the purified plasma discharged from the blood filter 213 is returned to the body by the return device.

In addition, the plasma purification system can be divided into two relatively independent systems of centrifugal plasma replacement and membrane type blood purification, and can be used for simultaneously carrying out artificial liver treatment of different modes on two patients, so that the application of the plasma purification system has flexibility and versatility. The membrane blood purification includes various treatment methods such as membrane plasmapheresis, plasma adsorption, and hemodiafiltration.

In the plasmapheresis system, the specific structure of the blood separation device is designed and selected according to actual needs, and for example, the blood separation device may be selected as a blood centrifugal separation device. Specifically, the blood separation apparatus includes: a blood collection line 11, a centrifugal separation device 12, a blood cell output line 14, a plasma output line 13, and a plasma collector 131.

Wherein, the blood collecting pipeline 11 is used for inputting blood to the centrifugal separation device 12, and the blood collecting pipeline 11 is provided with a blood collecting pump 110; the blood cell output pipeline 14 is communicated with the centrifugal separation device 12 and the feedback device; the plasma output pipeline 13 is communicated with the centrifugal separation device 12 and the waste plasma collecting device 131, a plasma collecting pump 130 is arranged on the plasma output pipeline 13, the plasma conveying pipeline 21 can be communicated with the plasma output pipeline 13, and the communication position of the plasma conveying pipeline 21 and the plasma output pipeline 13 is positioned at the downstream of the plasma collecting pump 130.

The type of the centrifugal separation device 12 is selected according to actual needs, for example, the centrifugal separation device 12 is a belt-type blood centrifugal separation device, which is not limited in this embodiment.

In order to avoid plasma coagulation, the blood collection line 11 is provided with a second heparin pump 112. In order to prevent the gas from entering the subsequent flow path, the blood collection tube 11 is provided with a third liquid container 111.

In order to prevent air bubbles from entering the centrifugal separation device 12, the blood collection tube 11 is provided with a third solution pot 111, and a second heparin pump 112 is connected to the blood collection tube 11 through the third solution pot 111.

The plasma delivery line 21 can communicate with the plasma output line 13, and for convenience of adjustment, the plasma output line 13 and the plasma delivery line 21 can be selected to communicate with each other through a second three-way valve 132. Specifically, the second three-way valve 132 is connected in series to the plasma delivery line 21, and the plasma output line 13 is communicated with the plasma delivery line 21 through the second three-way valve 132; alternatively, the second three-way valve 132 is connected in series to the plasma discharge line 13, and the plasma transport line 21 communicates with the plasma discharge line 13 via the second three-way valve 132.

If the second three-way valve 132 is at the first valve position, the plasma output line 13 connects the plasma collector 131 and the centrifugal separator 12; if the second three-way valve 132 is at the second valve position, the plasma outlet line 13 and the plasma delivery line 21 are connected.

In the plasma exchange system, the pumping speed of the blood collection pump 110 is selected to be 40-60 ml/min, the pumping speed of the plasma collection pump 130 and the plasma return pump 322 in the return device is selected to be 25-30 ml/min. During ultrafiltration, the plasma collection pump 130 of the blood separation device pumps at a pump speed that is the sum of the pump speed of the plasma return pump 322 and the ultrafiltration speed.

In practical applications, the pump speeds of the blood collection pump 110, the plasma collection pump 130, and the plasma return pump 322 may be selected to be other, and are not limited to the above embodiments.

In the plasma exchange system, the specific structure of the back-infusion device is selected according to actual needs. Specifically, the feedback device includes: a plasma return line 32, a plasma return pump 322 disposed on the plasma return line 32, a blood return line 31, and a blood return pump 310 disposed on the blood return line 31. The plasma output line 25 and the plasma reservoir 320 are both communicated with the plasma return line 32, and the blood cell output line 14 and the plasma return line 32 of the blood separation device are both communicated with the blood return line 31.

In order to ensure that the temperature of the plasma is within a predetermined range, a third heating device 321 is disposed on the plasma return line 32. In order to prevent air bubbles from entering the human body, the blood return line 31 is provided with a fourth fluid pot 311, and the plasma return line 32 and the blood cell output line 14 are both communicated with the blood return line 31 through the fourth fluid pot 311.

In the blood processing system, the first pot 243, the second pot 223, the third pot 111 and the fourth pot 311 are collectively referred to as a pot, and each of the pots has a liquid level detection sensor provided to monitor a liquid level in the pot.

To more specifically explain the plasmapheresis device and the plasmapheresis system provided in this embodiment, the operation of the plasmapheresis system will be explained with reference to fig. 1.

As shown in fig. 1, the present embodiment provides a plasma purification system including: a blood separation device, a feedback device and a plasma adsorption dialysis filtering device.

When the plasma purifying system carries out plasma replacement, the blood separating device and the feedback device work, and at the moment, the plasma replacement system forms a centrifugal separation plasma replacement system; when plasma adsorption and rapid diafiltration are required, the blood separation device, the plasma adsorption diafiltration device and the feedback device work, and at the moment, the plasma purification system forms a plasma adsorption diafiltration system. In addition, the plasma purification system can form two independent systems of a centrifugal separation plasma exchange system and a membrane type plasma purification system.

The use method of the plasma purification system provided by the above embodiment is as follows:

before treatment, heparin normal saline is used for respectively pre-filling the blood separation device, the plasma absorption dialysis filtering device and the return device by pipelines; plasma is centrifugally separated by the blood separation device, citric acid or low-molecular heparin is used for anticoagulation in the separation process, the second three-way valve 132 is adjusted to the first valve position, centrifugal plasma replacement can be carried out, specifically, the separated plasma enters the plasma collector 131 from the plasma output pipeline 13 under the driving of the plasma collecting pump 130, meanwhile, fresh plasma in the plasma storage 320 enters the plasma return pipeline 32 under the driving of the plasma return pipeline 322, and is returned to the body from the blood return pipeline 31 after being converged with blood cells conveyed by the blood cell output pipeline 14; after the plasma replacement is completed, the second three-way valve 132 is adjusted to the second valve position, so that the plasma output pipeline 13 is communicated with the plasma conveying pipeline 21, and the centrifugal separation device 12 is not communicated with the plasma collector 131 any more; the plasma is driven by the input pump 210 to sequentially pass through the first adsorber 211, the second adsorber 212 and the blood filter 213, and plasma double adsorption and dialysis filtration treatment is carried out; part of the purified plasma returns to the plasma return line 32 through the plasma output line 25 to be merged with blood cells and then returned to the body, and the other part of the plasma merges with the adsorbed purified plasma through the circulating dialysis line 26 and then enters the blood filter 213 again for circulating dialysis filtration.

When plasma dialysis filtration is performed, the pump speed of the input pump 21 is controlled to be 200ml/min at 150-; when ultrafiltration is performed in the membrane section, the pump speed of the plasma collection pump 130 in the centrifuge section is set to be the sum of the pump speed of the plasma return pump 322 and the ultrafiltration speed.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.