阅读说明：本技术 水基分散体系 (Aqueous dispersion ) 是由 全丹毅 杨清林 周亚涵 于 2021-10-13 设计创作，主要内容包括：本发明涉及材料领域,具体涉及一种粘多糖水基分散体系,用于获得该粘多糖水基分散体系的组合物,以及含有该粘多糖水基分散体系的复合高分子膜。所述组合物包括粘多糖组分和分散系组分,其中粘多糖组分包括A类粘多糖和B类粘多糖,所述A类粘多糖的性质包括：分子量为1500KDa-8000KDa；所述B类粘多糖的性质包括：分子量为0.5KDa-800KDa；所述A类粘多糖和所述B类粘多糖的重量比为1：(0.2-20)。本发明的组合物所得的粘多糖水基分散体系更加均匀稳定、粘性更低,能够与高分子膜有更好的相容性,所得的复合高分子膜具有更高的应用价值。(The invention relates to the field of materials, in particular to a mucopolysaccharide water-based dispersion system, a composition for obtaining the mucopolysaccharide water-based dispersion system and a composite polymer film containing the mucopolysaccharide water-based dispersion system. The composition comprises a mucopolysaccharide component and a dispersion component, wherein the mucopolysaccharide component comprises a group A mucopolysaccharide and a group B mucopolysaccharide, and the properties of the group A mucopolysaccharide comprise: the molecular weight is 1500KDa-8000 KDa; the properties of the group B mucopolysaccharides include: the molecular weight is 0.5KDa-800 KDa; the weight ratio of the A-type mucopolysaccharide to the B-type mucopolysaccharide is 1: (0.2-20). The mucopolysaccharide water-based dispersion system obtained by the composition is more uniform and stable, has lower viscosity, can have better compatibility with a polymer film, and the obtained composite polymer film has higher application value.)

1. A composition of an aqueous dispersion of mucopolysaccharides, the composition comprising a mucopolysaccharide component and a dispersion component, wherein the mucopolysaccharide component comprises a class a mucopolysaccharide and a class B mucopolysaccharide, wherein the properties of the class a mucopolysaccharide include: the molecular weight is 1500KDa-8000 KDa; the properties of the group B mucopolysaccharides include: the molecular weight is 0.5KDa-1499 KDa; and the difference between the molecular weight of the mucopolysaccharide A and the molecular weight of the mucopolysaccharide B is not less than 300 KDa; the weight ratio of the A-type mucopolysaccharide to the B-type mucopolysaccharide is 1: (0.2-20).

2. The composition of claim 1, wherein the weight ratio of the group a mucopolysaccharide to the group B mucopolysaccharide is 1: (3-20), preferably 1: (5-12).

3. The composition according to claim 1 or 2, wherein the mucopolysaccharide of group a is a polysaccharide of molecular weight comprising sodium hyaluronate with a molecular weight of 1600KDa-2500KDa and/or heparin with a molecular weight of 4000KDa-7000 KDa;

preferably, the mucopolysaccharide A is prepared from hyaluronic acid with molecular weight of 1600-2500 KDa and heparin with molecular weight of 4000-7000 KDa in a weight ratio of 1: (0.3-0.8).

4. The composition according to claim 1 or 2, wherein the mucopolysaccharide group B is selected from one or more of chondroitin sulfate having a molecular weight of 20KDa-50KDa, sodium hyaluronate having a molecular weight of 100KDa-1400 KDa, and heparin having a molecular weight of 150KDa-550 KDa;

preferably, said mucopolysaccharides of group B comprise at least chondroitin sulfate having a molecular weight ranging from 20kDa to 50 kDa;

preferably, the mucopolysaccharide B is prepared by mixing chondroitin sulfate with the molecular weight of 20-50 KDa and sodium hyaluronate with the molecular weight of 100-1400 KDa and/or heparin with the molecular weight of 150-550 KDa in a weight ratio of 1: (0.1-0.5).

5. A composition according to any one of claims 1 to 4, wherein the weight of the dispersion component is 40 to 200 times, preferably 60 to 80 times the weight of the mucopolysaccharide component.

6. The composition according to claim 1, wherein the dispersion system component contains a hydrophilic group selected from one or more of a hydroxyl group, a carboxylic acid group, a sulfonic acid group, a sulfuric acid group, a phosphoric acid group and an amino group, and a hydrophobic group selected from one or more of an alkyl group, an aromatic group and an aralkyl group.

7. The composition of claim 1 or 6, wherein the dispersion component comprises glycerin, sorbitol, and glycol in a weight ratio of 1: (0.1-1): (0.05-1), preferably 1: (0.35-0.45): (0.2-0.35).

8. An aqueous mucopolysaccharide dispersion comprising or produced from a composition according to any one of claims 1 to 7.

9. The aqueous mucopolysaccharide dispersion of claim 8, wherein the aqueous mucopolysaccharide dispersion is prepared by a process comprising the steps of:

(1) mixing the A-type mucopolysaccharide with 30-70% of the dispersion system component and 0-100% of water to obtain a first material;

(2) mixing the B-type mucopolysaccharide with the rest of the dispersion system components and the rest of the water to obtain a second material;

(3) the first material is mixed with the second material and a pH adjusting agent is added so that the pH of the liquid is 4-6.

10. A composite polymeric film comprising a polymeric film and a mucopolysaccharide aqueous dispersion spread thereon, said mucopolysaccharide aqueous dispersion being the mucopolysaccharide aqueous dispersion of claim 8 or 9.

Technical Field

The invention relates to the field of materials, in particular to a mucopolysaccharide water-based dispersion system, a composition for obtaining the mucopolysaccharide water-based dispersion system and a composite polymer film containing the mucopolysaccharide water-based dispersion system.

Background

The water-based dispersion system is a dispersed semi-solid multiphase system between a solvent and a gel, and can form a condensed state with certain rheological property. Because of its good biocompatibility, it is used in the medical and health fields.

Mucopolysaccharides are a generic term for the glycan moiety of proteoglycan macromolecules. Consisting of repeating disaccharide units of sugar amines, one of which is usually an amino-containing sugar, the other is often a uronic acid, and the hydroxyl groups of the sugar group are often sulfated. Mucopolysaccharides can be classified into chondroitin sulfate, dermatan sulfate, keratan sulfate, hyaluronic acid, heparin, heparan sulfate, and the like. With the continuous and intensive chemical research and development, it is found that mucopolysaccharide has various functions, participates in various activities of cells in life phenomena, and is a natural biochemical substance existing in human body, thus having good biocompatibility and safety.

An important application of the aqueous mucopolysaccharide dispersion is spreading on the surface of the polymeric membrane as a lubricant and wetting agent or as a drug delivery system, so that the polymeric membrane spread with the aqueous mucopolysaccharide dispersion is more effective and comfortable in life and medical treatment, such as anticoagulant, hypolipidemic, antiviral, antitumor and radioresistant applications.

However, such a polymeric film spread with a mucopolysaccharide aqueous dispersion has some drawbacks due to the influence of the properties of mucopolysaccharide itself, such as: mucopolysaccharides are difficult to disperse uniformly in a dispersion medium and cause a reduction in their properties; the high-viscosity mucopolysaccharide water-based dispersion system is unstable, has poor compatibility with a polymer film and is not easy to disperse, thereby limiting the application of the high-viscosity mucopolysaccharide water-based dispersion system in various fields.

Therefore, it is very important to develop a mucopolysaccharide aqueous dispersion system more suitable for use with a polymeric membrane.

Disclosure of Invention

The present invention has been made to overcome the above problems occurring in the prior art, and an object of the present invention is to provide a mucopolysaccharide aqueous dispersion, a composition for obtaining the mucopolysaccharide aqueous dispersion, and a composite polymeric film comprising the mucopolysaccharide aqueous dispersion. The mucopolysaccharide water-based dispersion system obtained by the composition is more uniform and stable, has lower viscosity, can have better compatibility with a polymer film, and the obtained composite polymer film has higher application value.

In order to achieve the above object, the present invention provides in a first aspect a composition for an aqueous dispersion of mucopolysaccharides, the composition comprising a mucopolysaccharide component and a dispersion component, wherein the mucopolysaccharide component comprises a class a mucopolysaccharide and a class B mucopolysaccharide, the properties of said class a mucopolysaccharide including: the molecular weight is 1500KDa-8000 KDa; the properties of the group B mucopolysaccharides include: the molecular weight is 0.5KDa-1499 KDa; and the difference between the molecular weight of the mucopolysaccharide A and the molecular weight of the mucopolysaccharide B is not less than 300 KDa; the weight ratio of the A-type mucopolysaccharide to the B-type mucopolysaccharide is 1: (0.2-20).

The present inventors have also found that the choice of mucopolysaccharide is also very important in forming aqueous mucopolysaccharide dispersions with good dispersibility, stability and compatibility with polymeric membranes. The inventors of the present invention have conducted extensive studies and found that the above-mentioned three properties can be effectively improved by blending different specific mucopolysaccharides in a specific ratio.

Preferably, the weight ratio of said group a mucopolysaccharide to said group B mucopolysaccharide is 1: (3-20), more preferably 1: (5-12).

Preferably, the difference between the molecular weight of said group a mucopolysaccharide and said group B mucopolysaccharide is not less than 400 KDa.

In the present invention, the compounds of said group a mucopolysaccharides and said group B mucopolysaccharides may be the same or different. In other words, the mucopolysaccharides of group a and the mucopolysaccharides of group B are not classified by kind, but by the above-described properties, for example, sodium hyaluronate with different molecular weights.

Preferably, said mucopolysaccharide group a and said mucopolysaccharide group B are each independently selected from one or more of sodium hyaluronate, chondroitin sulfate, chondroitin, heparin and keratan sulfate.

Preferably, the mucopolysaccharide A is sodium hyaluronate with molecular weight of 1600-2500 KDa and/or heparin with molecular weight of 4000-7000 KDa.

According to a preferred embodiment, the mucopolysaccharide a is prepared from hyaluronic acid with a molecular weight of 1600KDa to 2500KDa and heparin with a molecular weight of 4000KDa to 7000 KDa, in a weight ratio of 1: (0.3-0.8).

Preferably, the mucopolysaccharide B is selected from one or more of chondroitin sulfate having a molecular weight of 20kDa to 50kDa, sodium hyaluronate having a molecular weight of 100kDa to 1400 kDa (more preferably 600kDa to 1350kDa), and heparin having a molecular weight of 150kDa to 550kDa (more preferably 200kDa to 350 kDa).

More preferably, said mucopolysaccharides of group B comprise at least chondroitin sulfate having a molecular weight ranging from 20kDa to 50 kDa.

According to a preferred embodiment, said mucopolysaccharide B is prepared from chondroitin sulfate having a molecular weight of between 20KDa and 50KDa and sodium hyaluronate having a molecular weight of between 100KDa and 1400 KDa (more preferably between 600KDa and 1350KDa) and/or heparin having a molecular weight of between 150KDa and 550KDa (more preferably between 200KDa and 350KDa) in a weight ratio of 1: (0.1-0.5).

The weight ratio of the mucopolysaccharide component and the dispersion component may be adjusted as desired, for example, the weight of the dispersion component is 40 to 200 times, preferably 50 to 100 times, and more preferably 60 to 80 times the weight of the mucopolysaccharide component.

The dispersion component may be an aqueous based system as is conventional in the art for dispersing mucopolysaccharides.

The inventor of the present invention finds that the control of the types and the proportions of the hydrophilic groups and the hydrophobic groups in the water-based dispersion system is very important for improving the dispersibility, the stability and the compatibility of the high molecular weight polysaccharide. The proportion can realize better dispersibility, stability and compatibility of the polymer film.

The dispersion component contains a hydrophilic group and a hydrophobic group, and the hydrophilic group and the hydrophobic group may be provided by the same compound or different compounds.

Preferably, the hydrophilic group is selected from one or more of a hydroxyl group, a carboxylic acid group, a sulfonic acid group, a sulfuric acid group, a phosphoric acid group and an amino group.

Preferably, the hydrophobic group is selected from one or more of alkyl, aryl and aralkyl groups.

The present invention preferably uses compounds capable of providing both hydrophilic and hydrophobic groups to constitute the dispersion component, for example selected from polyols. Preferably, the dispersion component is selected from one or more of glycerol, sorbitol, mannitol, propylene glycol, dipropylene glycol, diglycerol, ethylene glycol, butylene glycol, isoprene glycol, pentylene glycol and hexylene glycol.

The inventors of the present invention further investigated and found that a combination of substances which produces a better synergistic effect, preferably the dispersion components comprise glycerol, sorbitol and glycol in a weight ratio of 1: (0.1-1): (0.05-1), more preferably 1: (0.25-0.6): (0.1-0.5), more preferably 1: (0.35-0.45): (0.2-0.35). The dihydric alcohol is selected from one or more of ethylene glycol, propylene glycol, butanediol, isoprene glycol, pentanediol and hexanediol.

The preferable combination mode of the invention can realize that the types and the proportions of the hydrophilic group and the hydrophobic group are in the preferable range, thereby being more suitable for being used in the matching with the polymer membrane, having better affinity with the polymer membrane and more uniform and stable spreading.

The invention claimed in a first aspect is a composition in which the individual components may be stored individually or in a mixture of several components. It will be appreciated that water may not be included in the composition for convenience of storage, transport and sale. The purchaser adds water to the mucopolysaccharide aqueous dispersion by himself.

According to a particular embodiment, the composition further comprises water. Preferably, the mucopolysaccharide component is present in an amount of from 0.05 to 5 wt%, the dispersion component is present in an amount of from 30 to 75 wt%, and the water is present in an amount of from 20 to 69.95 wt%, based on the total weight of the composition; more preferably, the mucopolysaccharide component is present in an amount of from 0.1 to 2 wt%, the dispersion component is present in an amount of from 40 to 65 wt%, and the water is present in an amount of from 33 to 59.9 wt%, based on the total weight of the composition; further preferably, the mucopolysaccharide component is present in an amount of 0.5 to 1 wt%, the dispersion component is present in an amount of 45 to 55 wt%, and the water is present in an amount of 44 to 54.5 wt%, based on the total weight of the composition.

The water is preferably deionized water.

The composition may also contain conventional adjuvants in the art, such as one or more of pH regulator, dispersant, emulsifier, silicone oil and modified silicone oil, essential oil, antioxidant, metal chelating agent, etc.

According to one embodiment, the composition further comprises a pH adjusting agent in an amount such that the aqueous mucopolysaccharide dispersion produced has a pH within a certain range (see description of the second aspect of the invention).

The pH adjusting agent may be selected from one or more of lactic acid, acetic acid and citric acid, for example.

The composition may also contain a drug, as required. The choice and amount of drug is selected according to the specific needs.

In a second aspect, the present invention provides an aqueous mucopolysaccharide dispersion comprising or produced from a composition according to the first aspect of the invention.

The aqueous mucopolysaccharide dispersion of the second aspect of the invention may be obtained by simply mixing the composition of the first aspect (with the exception of water when no water is present in the composition).

Preferably, the surface tension of the aqueous mucopolysaccharide dispersion is from 35 to 120 mN.m^-1More preferably 40 to 70mN · m^-1。

According to a preferred embodiment, the aqueous mucopolysaccharide dispersion of the second aspect of the invention is prepared by a process comprising the steps of:

(1) mixing the A-type mucopolysaccharide with 30-70% of a dispersion system component and water to obtain a first material;

(2) mixing the B-type mucopolysaccharide with the rest of the dispersion system components to obtain a second material;

(3) the first material is mixed with the second material and a pH adjusting agent is added so that the pH of the liquid is 4-6.

And (3) mixing in the steps (1) to (3) by adopting a conventional stirring mode until the materials are fully and uniformly dispersed. For example, in the step (1), mixing and stirring are carried out for 1-3 h; mixing and stirring for 0.5-2h in the step (2).

In step (3), preferably, until the pH is 4.8-5.8.

In the present invention, preferably, after the pH is adjusted, a step of standing to remove bubbles is further included. The standing time is, for example, 1 to 4 hours.

The aqueous mucopolysaccharide dispersion of the second aspect of the invention is obtained by the above process.

In a third aspect, the present invention provides a composite polymeric film comprising a polymeric film and a mucopolysaccharide aqueous dispersion spread thereon, said mucopolysaccharide aqueous dispersion being the mucopolysaccharide aqueous dispersion of the second aspect.

Preferably, the polymeric membrane is selected from one or more of an ion exchange membrane, a microfiltration membrane, an ultrafiltration membrane, a reverse osmosis membrane, a nanofiltration membrane, an emulsion membrane, a drug release sustained release membrane and a segmentation effect protective membrane.

The mucopolysaccharide water-based dispersion system disclosed by the invention can have good compatibility with a polymer film, can be used for spreading a uniform and stable liquid film layer on the polymer film, and has a good application effect.

Through the technical scheme, compared with the prior art, the invention at least has the following advantages:

(1) the aqueous mucopolysaccharide dispersion of the present invention enables the viscosity to be at a low level;

(2) the dispersion of the mucopolysaccharide in the mucopolysaccharide water-based dispersion system is more uniform and more stable;

(3) the mucopolysaccharide water-based dispersion system has better compatibility with a polymer film, is easier to spread on the surface of the polymer film, is uniformly wetted and is not easy to permeate the polymer film;

(4) the composite polymer film can keep a moist state within not less than 20min when acting on human skin or mucosa.

The endpoints of the ranges and any values disclosed herein are not limited to the precise range or value, and such ranges or values should be understood to encompass values close to those ranges or values. For ranges of values, between the endpoints of each of the ranges and the individual points, and between the individual points may be combined with each other to give one or more new ranges of values, and these ranges of values should be considered as specifically disclosed herein.

Detailed Description

The present invention will be described in detail below by way of examples. The described embodiments of the invention are only some, but not all embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the following examples, the components used are all commercially available analytical grades, unless otherwise specified. 1 part by weight represents 1 mg.

Example 1

(1) Preparing the composition

1-a mucopolysaccharide component, comprising, in total, 1 part by weight:

mucopolysaccharide group a: 0.07 part by weight of sodium hyaluronate (weight average molecular weight of 1800kDa) and 0.03 part by weight of heparin (weight average molecular weight of 5000 kDa);

type B mucopolysaccharides: 0.70 parts by weight of chondroitin sulfate (weight-average molecular weight of 250kDa) and 0.20 parts by weight of heparin (weight-average molecular weight of 320 kDa);

2-a dispersion component, comprising, in total, 70 parts by weight:

glycerol: 42 parts by weight;

sorbitol: 17 parts by weight;

a dihydric alcohol: 12 parts by weight of hexanediol;

3-deionized water in an amount such that the mucopolysaccharide content is 0.7% by weight of the resulting mucopolysaccharide water-based dispersion product;

4-pH regulator, lactic acid.

(2) Preparation of aqueous mucopolysaccharide dispersions

1-premixing the A-type mucopolysaccharide and glycerol, uniformly stirring, adding deionized water, and stirring for 2 hours;

2-after the solution is transparent, adding sorbitol and dihydric alcohol and stirring for 1 h;

3-adding a pH regulator lactic acid after stirring is finished, and regulating the pH to 5.5;

4-standing to remove bubbles;

obtaining clear and transparent liquid, namely the mucopolysaccharide water-based dispersion system product.

Example 2

(1) Preparing the composition

1-a mucopolysaccharide component, comprising, in total, 1 part by weight:

mucopolysaccharide group a: 0.1 part by weight of sodium hyaluronate (weight average molecular weight of 2000KDa) and 0.07 part by weight of heparin (weight average molecular weight of 6500 KDa);

type B mucopolysaccharides: 0.83 parts by weight of chondroitin sulfate (weight-average molecular weight of 50 kDa);

2-a dispersion component comprising, in total 60 parts by weight:

glycerol: 35 parts by weight;

sorbitol: 12 parts by weight;

a dihydric alcohol: 12 parts of butanediol;

3-deionized water in an amount such that the mucopolysaccharide content is 1% by weight of the resulting mucopolysaccharide water-based dispersion product;

4-pH regulator, lactic acid.

(2) Preparation of aqueous mucopolysaccharide dispersions

Reference was made to the procedure of example 1.

Obtaining the mucopolysaccharide water-based dispersion system product.

Example 3

(1) Preparing the composition

1-a mucopolysaccharide component, comprising, in total, 1 part by weight:

mucopolysaccharide group a: 0.08 part by weight of sodium hyaluronate (weight average molecular weight of 2500 kDa);

type B mucopolysaccharides: 0.8 part by weight of chondroitin sulfate (weight-average molecular weight of 25kDa) and 0.12 part by weight of sodium hyaluronate (weight-average molecular weight of 1300 kDa);

2-a dispersion component, comprising, in total 80 parts by weight:

glycerol: 48 parts by weight;

sorbitol: 22 parts by weight;

a dihydric alcohol: 10 parts of pentanediol;

3-deionized water in an amount such that the mucopolysaccharide content is 0.5% by weight of the resulting mucopolysaccharide water-based dispersion product;

4-pH regulator, lactic acid.

(2) Preparation of aqueous mucopolysaccharide dispersions

Reference was made to the procedure of example 1.

Obtaining the mucopolysaccharide water-based dispersion system product.

EXAMPLE 4 group

This set of examples serves to illustrate the effect of the mucopolysaccharide component.

This set of examples was conducted according to the compositions and methods of example 1, except that the components and/or amounts of the mucopolysaccharide component were varied separately. Specifically, the method comprises the following steps:

example 4 a: changing the ratio of two kinds of mucopolysaccharide and keeping the components unchanged, specifically, 0.5 weight part of A kind of mucopolysaccharide and 0.5 weight part of B kind of mucopolysaccharide;

example 4 b: mucopolysaccharide group a: 0.1 part by weight of sodium hyaluronate (weight average molecular weight of 6000 KDa); type B mucopolysaccharides: 0.90 parts by weight of heparin (weight-average molecular weight 750 kDa).

Respectively obtaining the final mucopolysaccharide water-based dispersion system products.

EXAMPLE 5 group

This set of examples serves to illustrate the effect of the dispersion components.

This set of examples was conducted according to the compositions and methods of example 1, except that the ingredients and/or the contents of the dispersion components were changed separately. Specifically, the method comprises the following steps:

example 5 a: changing the proportion of the three components, specifically, 24 parts by weight of glycerin, 23 parts by weight of sorbitol and 23 parts by weight of hexanediol;

example 5 b: changing into binary components and keeping the total weight unchanged, specifically, 35 parts by weight of glycerin and 35 parts by weight of hexanediol;

example 5 c: the specific selection of the three components was changed while keeping the total weight unchanged, specifically, 24 parts by weight of triglyceride, 23 parts by weight of maltitol, and 23 parts by weight of ethylene glycol.

Respectively obtaining the final mucopolysaccharide water-based dispersion system products.

Example 6

This set of examples was conducted according to the composition and method of example 1, except that the amount of deionized water was changed so that the mucopolysaccharide content was 3% by weight of the resulting aqueous mucopolysaccharide dispersion product.

Finally obtaining the mucopolysaccharide water-based dispersion system product.

Comparative example 1

The procedure is as in example 1, except that a single component of mucopolysaccharide, 1 part by weight, sodium hyaluronate, weight average molecular weight 1800kDa, is used.

Finally obtaining the mucopolysaccharide water-based dispersion system product.

Comparative example 2

The procedure is as in example 1, except that the properties of the mucopolysaccharide are modified, in particular:

the mucopolysaccharide is composed of 0.10 weight part of sodium hyaluronate (weight average molecular weight of 600kDa) and 0.90 weight part of heparin (weight average molecular weight of 5000 kDa).

Finally obtaining the mucopolysaccharide water-based dispersion system product.

Test example

The reagents obtained in the examples and comparative examples were subjected to the following tests, respectively:

(1) viscosity and stickiness

And (3) viscosity testing: adopting a rotary viscometer to detect viscosity, detecting at room temperature, recording the viscosity value (CPS) in table 1 at the rotating speed of 30rpm, wherein the viscosity is generally higher when the viscosity value of a formula with similar components is higher;

and (3) viscosity test: placing a reagent with the same solid content (free moisture in a sample is not calculated) on a clean stainless steel liquid plane, drying until the free moisture is removed, placing the stainless steel plane at 90 degrees vertically, observing the descending distance (mm) of the lower end of the sample after 24 hours, and recording the descending distance (mm) in table 1, wherein the larger the descending distance is, the smaller the viscosity is;

for aqueous mucopolysaccharide dispersions, the viscosity is less desirable when the viscosity is satisfactory (both the above examples and comparative examples achieve suitable viscosities).

2) Compatibility of polymer film

The test process comprises the following steps: taking a latex film with a certain area, placing weighing paper with the same area below the latex film, flatly paving the latex film on a smooth table top, dropwise adding a reagent into the middle of a polymer film, and placing the polymer film in a sealed environment; each example was repeated 6 times in parallel, the wetted area of the material was observed after 7 days, the average wetted area was calculated and reported in table 1, the larger the wetted area, the better the spreadability of the product on the polymeric membrane; the weight change before and after the paper test was weighed, the difference in weight was divided by the weight of the dripped sample to obtain the percent transmittance, and the calculated average transmittance (%) is shown in table 1, with smaller transmittances indicating better compatibility of the product with the polymer film.

The latex membrane was replaced with an ion exchange membrane, a microfiltration membrane, an ultrafiltration membrane, a reverse osmosis membrane, a nanofiltration membrane, a latex membrane, a drug release sustained-release membrane, and a segmentation protective membrane, and the above tests were repeated, and the magnitude relationship between each example and the comparative example in the test results of these polymeric membranes showed substantially the same rule as in table 1, and the data are not listed one by one here.

3) Retention property:

the test process comprises the following steps: in a constant temperature and humidity environment, a certain amount of sample is applied to human skin, and after 20min, whether the sample still has a wet state after friction is observed, and yes (still having a wet state) or no (no wet state) is shown in table 1.

4) The reagents of the examples are respectively filled (the liquid level height is 10cm), sealed and placed at room temperature, and no obvious layering phenomenon is observed after the reagents are placed for 6 months.

TABLE 1

As can be seen from Table 1, the mucopolysaccharide water-based dispersion system obtained by the composition of the invention has lower viscosity, is more uniform and stable, has good compatibility with a polymer film and lower transmittance, and thus has higher application value.

The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.