阅读说明：本技术 一种唇釉及其制备方法 (Lip glaze and preparation method thereof ) 是由 宫圆圆 贾凯 于钰 丁松 李军 于 2021-09-02 设计创作，主要内容包括：本发明提供了一种唇釉,至少包含了抗氧化剂和基础基质,所述的抗氧化剂包含重量比为1：2：4：10的虾青素、丁羟甲苯、生育酚、乳香树脂提取物,或所述的抗氧化剂包含重量比为1：2：4的虾青素、丁羟甲苯、生育酚。本发明的提供的唇釉组合物能够有效保留虾青素的颜色,使各种抗氧化物质协同作用,更好的发挥其作用,同时给予组合物良好的外观效果；不仅能够增强唇部的保湿效果,也能够促进唇部对活性物质的吸收,维持纳米微针操作后的效果,淡化唇纹,增强唇色,符合唇部修复机理。本发明还提供了一种唇釉的制备方法。(The invention provides a lip glaze, which at least comprises an antioxidant and a base matrix, wherein the antioxidant comprises the following components in a weight ratio of 1: 2: 4: 10 of astaxanthin, butylated hydroxytoluene, tocopherol, boswellia resin extract, or said antioxidant comprises a mixture of 1: 2: 4 astaxanthin, butylated hydroxytoluene and tocopherol. The lip glaze composition provided by the invention can effectively retain the color of astaxanthin, enables various antioxidant substances to act synergistically, better exerts the effect of the astaxanthin, and simultaneously gives a good appearance effect to the composition; the lip moisturizing effect can be enhanced, the lip can be promoted to absorb active substances, the effect of the nano microneedle after operation is maintained, the cheilogramma is lightened, the lip color is enhanced, and the lip repairing mechanism is met. The invention also provides a preparation method of the lip glaze.)

1. A lip glaze comprising:

an antioxidant comprising astaxanthin, butylated hydroxytoluene and tocopherol;

a base matrix.

2. The lip glaze according to claim 1, wherein the mass ratio of the astaxanthin, the butylated hydroxytoluene and the tocopherol is 1: (1-3): (2-5).

3. The lip glaze according to claim 1, wherein the antioxidant further comprises mastic resin extract.

4. The lip glaze according to claim 3, wherein the mass ratio of the astaxanthin to the mastic extract is 1: (8-12).

5. The lip glaze according to claim 1, wherein the base substrate comprises: moisturizers and emollients.

6. The lip glaze according to claim 5, wherein the humectant is selected from one or more of jojoba seed oil, hyaluronic acid, oligopeptide-1, bisabolol, sunflower seed oil and ginger root extract.

7. The lip glaze according to claim 5, wherein the emollient is selected from one or more of octyldodecanol, isostearyl alcohol, ethylene-propylene-styrene copolymer, butylene-ethylene-styrene copolymer, hexyldecanol, cetyl N-palmitoylhydroxyproline ester, and stearic acid.

8. The lip glaze according to claim 5, wherein the mass ratio of the antioxidant to the base matrix is (0.05-0.85): (99.15-99.95).

9. The lip glaze according to claim 5, wherein the mass ratio of the humectant to the emollient is 16: (83.15-83.95).

10. A method of preparing a lip glaze as claimed in claim 1, comprising:

and mixing the antioxidant with the basic matrix to obtain the lip glaze.

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to lip glaze and a preparation method thereof.

Background

As the aging of the human body progresses with age, the aging of the lips is also receiving increasing attention. As aging progresses, the volume of the lips and surrounding tissue decreases, the epithelial lips between the columella and vermilion lips begin to elongate, the corners of the mouth sag downward, the cupular arch flattens, and the medial column loses prominence. With the long-term use of facial muscles, particularly the orbicularis oris muscle, the formation of perioral wrinkles on the vermilion lip is accelerated and the radial shape is presented, and at the same time, the downward trend of the mouth angle is aggravated by the activity of the lowering-angle muscle. Thus, aging of the lips manifests itself as changes in the lip surface and changes in the lip shape. Early aging of the lips, manifested as the appearance of superficial wrinkles on the lips, while the upper lips were still short and non-elongated, and the vermilion color of the lips began to fade gradually.

The existing treatment schemes aiming at lip aging are divided into surgical treatment and non-surgical treatment, much attention is paid to the surgical treatment, but the lip aging surgery is still in a development stage, and particularly, various postoperative complications limit the development, so the non-surgical treatment plays a considerable role in the lip aging. Especially for early aging of lips, the effect of non-surgical treatment is more prominent.

When the nano micro needle shapeless array acts on the skin, the nano micro needle shapeless array only penetrates through the cuticle layer of the epidermis without piercing the corium layer, greatly improves the penetration of active substances into the skin, is safe, painless and noninvasive, and is greatly popular with consumers. However, the nano-micro-needle still has a small area of wound after being used, so that the corresponding product is required to be used, the complications such as inflammation and the like are prevented, and the active substances can be promoted to permeate into the skin. However, most of the operations of the nano microneedle cosmetic are applied to facial skin, and are matched with products for whitening, resisting wrinkles, removing scars and the like, and lip glaze composition products applied after the nano microneedle cosmetic are used can promote healing of lip wound surfaces, prevent inflammation and promote effective utilization of active substances.

Disclosure of Invention

In view of the above, the present invention provides a lip glaze and a preparation method thereof, wherein the lip glaze provided by the present invention can effectively retain the color of astaxanthin, and enables various antioxidant substances to act synergistically, thereby exerting a better effect and providing a good appearance effect.

The invention provides a lip glaze, which comprises:

an antioxidant comprising astaxanthin, butylated hydroxytoluene and tocopherol;

a base matrix.

Preferably, the mass ratio of the astaxanthin to the butylated hydroxytoluene to the tocopherol is 1: (1-3): (2-5).

Preferably, the antioxidant further comprises mastic resin extract.

Preferably, the mass ratio of the astaxanthin to the boswellia resin extract is 1: (8-12).

Preferably, the base matrix comprises: moisturizers and emollients.

Preferably, the humectant is selected from one or more of jojoba seed oil, hyaluronic acid, oligopeptide-1, bisabolol, sunflower seed oil and ginger root extract.

Preferably, the emollient is one or more selected from octyldodecanol, isostearyl alcohol, ethylene-propylene-styrene copolymer, butylene-ethylene-styrene copolymer, hexyldecanol, cetyl N-palmitoyl hydroxyproline ester and stearic acid.

Preferably, the mass ratio of the antioxidant to the basic matrix is (0.05-0.85): (99.15-99.95).

Preferably, the mass ratio of the humectant to the emollient is 16: (83.15-83.95).

The invention provides a preparation method of lip glaze in the technical scheme, which comprises the following steps:

and mixing the antioxidant with the basic matrix to obtain the lip glaze.

According to the invention, the butylated hydroxytoluene, the boswellia resin extract and the tocopherol are simultaneously added into the lip glaze, so that the color of the astaxanthin is well maintained, the color stability of the composition is further maintained, and a good visual effect is achieved; meanwhile, the color of the astaxanthin is stably maintained, namely the antioxidant effect of the lip glaze is well maintained, and the astaxanthin and other components act together to achieve the effects of removing lip wrinkles and eliminating lip darkness. The nanometer micro-needle dressing can promote wound recovery after micro-needle operation, can promote effective components in lip glaze to permeate into lip skin through micro-needle operation, enhances bioavailability of active components in the lip glaze, and achieves the effects of removing lip wrinkles, eliminating lip darkness and moisturizing under combined action.

The aging of lips is mainly characterized in that the upper and lower vermilion lips tend to be flat, the color of the lips is gradually dull, the lips are easy to dry, vertical fine lines appear, and the outline of the lips is unclear. The lip glaze provided by the invention can relieve the lip aging tendency from two aspects, and can be used after the operation of the nano micro-needle by utilizing the antioxidant active substance composition. The lip glaze provided by the invention can effectively retain the color of astaxanthin, enables various antioxidant substances to act synergistically, better plays a role and simultaneously gives a good appearance effect; the lip nanometer microneedle is used after operation, so that the moisturizing effect of lips can be enhanced, the lip can be promoted to absorb active substances, the effect of the nanometer microneedle after operation is maintained, lip wrinkles are reduced, lip color is enhanced, and the lip repairing mechanism is met.

Drawings

FIG. 1 is a graph of astaxanthin standard curve;

FIG. 2 shows the retention rate test results of lip glaze prepared in example 1 of the present invention;

FIG. 3 shows the retention rate test results of lip glaze prepared in example 2 of the present invention;

FIG. 4 shows the retention rate test results of lip glaze prepared in example 3 of the present invention;

FIG. 5 shows the retention rate test results of lip glaze prepared in example 4 of the present invention;

FIG. 6 shows the retention rate test results of lip glaze prepared in example 5 of the present invention;

FIG. 7 shows the retention rate test results of lip glaze prepared in example 6 of the present invention;

FIG. 8 shows the retention rate test results of lip glaze prepared in example 7 of the present invention;

FIG. 9 shows the retention rate test results of lip glaze prepared in example 8 of the present invention;

FIG. 10 shows the retention rate test results of lip glaze prepared in example 9 of the present invention;

FIG. 11 shows the retention rate test results of lip glaze prepared in example 10 of the present invention;

FIG. 12 shows the retention rate test results of lip glaze prepared in example 11 of the present invention;

FIG. 13 shows the retention rate test results of lip glaze prepared in example 12 of the present invention;

FIG. 14 shows the retention rate test results of lip glaze prepared in example 13 of the present invention;

FIG. 15 shows the retention rate test results of lip glaze prepared in example 14 of the present invention;

FIG. 16 shows the retention rate test results of lip glaze prepared in example 15 of the present invention;

fig. 17 is an operational view of nano-microneedles;

fig. 18 is a lip wrinkle measurement result using the lip glaze prepared in example 5 after nano-microneedle treatment;

fig. 19 is a lip color measurement result of lip gloss using the lip glaze prepared in example 5 after nano microneedle treatment.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other examples, which may be modified or appreciated by those of ordinary skill in the art based on the examples given herein, are intended to be within the scope of the present invention. It should be understood that the embodiments of the present invention are only for illustrating the technical effects of the present invention, and are not intended to limit the scope of the present invention. In the examples, the methods used were all conventional methods unless otherwise specified.

The invention provides a lip glaze, which comprises:

an antioxidant comprising astaxanthin, butylated hydroxytoluene and tocopherol;

a base matrix.

In the present invention, the mass ratio of the astaxanthin, the butylated hydroxytoluene and the tocopherol is preferably 1: (1-3): (2-5), more preferably 1: (1.5-2.5): (3.5 to 4.5), most preferably 1: 2: 4.

in the present invention, the antioxidant preferably further comprises mastic resin extract.

In the present invention, the mass ratio of the astaxanthin to the mastic resin extract is preferably 1: (8-12), more preferably 1: (9-11), most preferably 1: 10.

in the present invention, the base matrix preferably comprises: moisturizers and emollients.

In the present invention, the humectant is preferably a penetration-promoting humectant, and more preferably one or more selected from jojoba seed oil, hyaluronic acid, oligopeptide-1, bisabolol, sunflower seed oil and ginger root extract.

In the present invention, the emollient is preferably one or more selected from octyldodecanol, isostearyl alcohol, ethylene-propylene-styrene copolymer, butylene-ethylene-styrene copolymer, hexyldecanol, cetyl N-palmitoyl hydroxyproline ester, and stearic acid.

In the invention, the mass ratio of the humectant to the emollient is preferably (0.05-0.85): (99.15 to 99.95), more preferably (0.1 to 0.8): (99.2 to 99.9), more preferably (0.2 to 0.7): (99.3 to 99.8), more preferably (0.3 to 0.6): (99.4 to 99.7), most preferably (0.4 to 0.5): (99.5-99.6).

In the present invention, the mass ratio of the antioxidant to the base matrix is preferably 16: (83.15-83.95), more preferably 16: (83.2 to 83.9), more preferably 16: (83.3 to 83.8), more preferably 16: (83.4 to 83.6), most preferably 16: 83.5.

the invention provides a preparation method of lip glaze in the technical scheme, which comprises the following steps:

and mixing the antioxidant with the basic matrix to obtain the lip glaze.

In the present invention, the preparation method of the lip glaze more preferably comprises:

carrying out first mixing on octyldodecanol, isostearyl alcohol, jojoba seed oil, an ethylene-propylene-styrene copolymer, a butylene-ethylene-styrene copolymer, hexyldecanol, cetyl N-palmitoyl hydroxyproline and stearic acid to obtain a mixture;

and secondly, mixing the mixture with oligopeptide-1, hyaluronic acid, ginger root extract, sunflower seed oil, astaxanthin, butylated hydroxytoluene, mastic extract, tocopherol and bisabolol to obtain lip glaze.

In the present invention, the first mixing is preferably performed under stirring; the heating temperature of the first mixing is preferably 80-85 ℃, more preferably 81-84 ℃, and most preferably 82-83 ℃; the heat preservation time of the first mixing is preferably 10-20 min, more preferably 12-18 min, more preferably 14-16 min, and most preferably 15 min.

In the invention, the mixture is preferably cooled to room temperature and then subjected to second mixing, wherein the temperature of the second mixing is preferably room temperature, and the temperature of the room temperature is preferably 20-30 ℃, more preferably 22-28 ℃, more preferably 24-26 ℃, and most preferably 25 ℃; the second mixing is preferably carried out under stirring, preferably uniformly.

According to the invention, the butylated hydroxytoluene, the boswellia resin extract and the tocopherol are simultaneously added into the lip glaze, so that the color of the astaxanthin is well maintained, the color stability of the composition is further maintained, and a good visual effect is achieved; meanwhile, the color of the astaxanthin is stably maintained, namely the antioxidant effect of the lip glaze is well maintained, and the astaxanthin and other components act together to achieve the effects of removing lip wrinkles and eliminating lip darkness. The nanometer micro-needle dressing can promote wound recovery after micro-needle operation, can promote effective components in lip glaze to permeate into lip skin through micro-needle operation, enhances bioavailability of active components in the lip glaze, and achieves the effects of removing lip wrinkles, eliminating lip darkness and moisturizing under combined action.

Examples 1 to 8

Accurately weighing the materials according to the components and the dosage in the table 1, firstly heating and stirring octyldodecanol, isostearyl alcohol, jojoba seed oil, ethylene-propylene-styrene copolymer, butylene-ethylene-styrene copolymer, hexyldecanol, cetyl palmitate hydroxyproline and stearic acid to 80-85 ℃, completely mixing uniformly, and then preserving heat for 15min to obtain a mixture;

cooling to room temperature, adding oligopeptide-1, hyaluronic acid, ginger root extract, sunflower seed oil, astaxanthin, butylated hydroxytoluene, boswellia resin extract, tocopherol and bisabolol into the mixture, and stirring and mixing uniformly to obtain lip glaze.

TABLE 1 ingredient formula for preparing lip gloss in examples 1-8

Examples 9 to 16

Accurately weighing the materials according to the dosage of the components in the table 2, firstly heating and stirring octyldodecanol, isostearyl alcohol, jojoba seed oil, ethylene-propylene-styrene copolymer, butylene-ethylene-styrene copolymer, hexyldecanol, cetyl N-palmitoyl hydroxyproline and stearic acid to 80-85 ℃, completely mixing uniformly, and then preserving heat for 15min to obtain a mixture.

Cooling to room temperature, adding oligopeptide-1, hyaluronic acid, ginger root extract, sunflower seed oil, astaxanthin, butylated hydroxytoluene, boswellia resin extract, tocopherol and bisabolol into the mixture, and stirring and mixing uniformly to obtain lip glaze.

TABLE 2 ingredient formula for lip glaze preparation in examples 9-16

Performance detection

Drawing an astaxanthin standard curve: preparing an absolute ethyl alcohol solution of astaxanthin to make the concentrations of the absolute ethyl alcohol solution of the astaxanthin respectively be 0 mug/mL, 200 mug/mL, 400 mug/mL, 600 mug/mL, 800 mug/mL and 1000 mug/mL; astaxanthin is prepared separately for each concentration, and a dilution method cannot be adopted to prepare an absolute ethanol solution of astaxanthin. And determining the linear relation between the concentration of the astaxanthin absolute ethyl alcohol solution and light absorption by taking the absolute ethyl alcohol of the astaxanthin with different concentrations as the abscissa and the light absorption value as the ordinate, and calculating a linear equation.

As shown in fig. 1, the standard curve of astaxanthin is y ═ 0.001x +0.010 (R)²＝0.999)

Measurement of astaxanthin retention: 1mL of lip glaze prepared in example was added with 3mL of absolute ethanol at 2000rpm/min, centrifuged for 5min, and the supernatant was collected and measured for absorbance at 492 nm.

According to the standard curve of the astaxanthin in the figure 1, respectively calculating the retention amount of the astaxanthin in the lip glaze and the retention rate of the astaxanthin in the lip glaze; the following formula:

astaxanthin retention (RR%) ═ A_n/A₀×100％

In the formula, A_nRepresents the amount of astaxanthin retained on day n, A₀The retention of astaxanthin on the first day of the initiation is shown.

The lip glaze prepared in example 1 was examined to find that the retention of astaxanthin by the combination of butylated hydroxytoluene and astaxanthin is as shown in fig. 2, and by day 30, the retention of astaxanthin was 5.34 ± 0.34%.

The results of the examination of example 2 show that the retention of astaxanthin by the combination of the mastic resin extract and astaxanthin is 69.56. + -. 2.33% on day 30 and 37.45. + -. 5.22% on day 60, as shown in FIG. 3.

The results of the examination of example 3 show that the retention of astaxanthin is 35.93. + -. 6.46% on day 30 and almost 0 on day 60, as shown in FIG. 4, when tocopherol and astaxanthin are combined.

The results of the measurement in example 4 show that the retention of astaxanthin is 75.50 + -7.01% on day 30 and 45.76 + -8.97% on day 60, as shown in fig. 5, when butylated hydroxytoluene, mastic resin extract and astaxanthin were combined.

The results of the measurement of example 5 show that the retention of astaxanthin is 87.99. + -. 4.33% on day 30 and 77.67. + -. 4.29% on day 60, when butylated hydroxytoluene, tocopherol and astaxanthin are combined, as shown in FIG. 6.

The results of the test of example 6 show that the retention of astaxanthin by the combination of the mastic extract, tocopherol and astaxanthin is 75.09 + -2.33% on day 30 and 44.67 + -5.22% on day 60, as shown in fig. 7.

The results of the test of example 7 show that the retention of astaxanthin is 91.09. + -. 8.46% on day 30 and 80.53. + -. 8.70% on day 60, when butylated hydroxytoluene, boswellia resin extract, tocopherol and astaxanthin were combined, as shown in FIG. 8.

The detection result of example 8 shows that the retention rate of astaxanthin in the composition alone is as shown in fig. 9, and the retention rate of astaxanthin at day 15 is 15.78 ± 6.02%; at day 30, the retention of astaxanthin was almost 0.

As shown in FIG. 9, the results of the tests of examples 1 to 8 were analyzed, and the retention of astaxanthin was 15.78. + -. 0.59% on day 15 and almost 0 on day 30 in the presence of astaxanthin alone. As shown in fig. 2 to 4, when the astaxanthin is added with butylated hydroxytoluene, the boswellia resin extract and the tocopherol respectively, the degradation rate of the astaxanthin can be slowed down by all three active substances, the retention rates of the astaxanthin after the addition are respectively 50.56 ± 4.12%, 83.67 ± 2.11% and 70.63 ± 3.68% at day 15, and the retention rates of the astaxanthin are respectively 5.34 ± 0.34%, 69.56 ± 2.33% and 35.93 ± 8.46% at day 30, so that the retention effects of the three active ingredients on the astaxanthin on the mammary gland resin extract are the best, the tocopherol is the second best and the butylated hydroxytoluene is the worst. The three active ingredients are compounded in pairs, as shown in figure 5, the butylated hydroxytoluene and the boswellia resin extract are compounded for use, the retention rate of the astaxanthin is 75.50 +/-7.01% on day 30, and the retention rate of the astaxanthin is 45.76 +/-8.97% on day 60; as shown in figure 6, when butylated hydroxytoluene and tocopherol are compounded for use, the retention rate of astaxanthin is 87.99 +/-4.33% on day 30, and the retention rate of astaxanthin is 77.67 +/-4.29% on day 60; as shown in FIG. 7, when the boswellia resin extract and tocopherol were used in combination, the retention of astaxanthin was 75.09. + -. 2.33% on day 30 and 44.67. + -. 5.22% on day 60. As can be seen from fig. 5 to 7, the effect of the active ingredients compounded in pairs to relieve the degradation of astaxanthin is remarkably enhanced, and the active ingredients have a remarkable effect on relieving the degradation of astaxanthin when being used alone, but the most remarkable effect is a composition of butylated hydroxytoluene and tocopherol, and the effect of lip glaze in examples 4 and 6 on relieving the degradation of astaxanthin is not significantly different. The effect of the three active ingredients of butylated hydroxytoluene, the boswellia serrata extract and the tocopherol on the astaxanthin degradation alleviation is shown in fig. 8, the retention rate of the astaxanthin is 91.09 +/-8.46% at the 30 th day, the retention rate of the astaxanthin is 80.53 +/-8.70% at the 60 th day, and experimental data show that the effect of the three active ingredients in combination on the astaxanthin degradation rate alleviation is most remarkable. However, the retention rate of astaxanthin in the three active ingredient combinations of example 7 is only about 3% higher than that in the two compositions of butylated hydroxytoluene and tocopherol of example 5, and the difference is not significant, and the two compositions of butylated hydroxytoluene and tocopherol of example 5 are better in terms of experimental results and cost saving.

The measurement result of example 9 was that 0.05g of butylated hydroxytoluene and astaxanthin were combined, the retention rate of astaxanthin was as shown in fig. 10, and by day 15, the retention rate of astaxanthin was 31.63 ± 4.64%; at day 30, the retention of astaxanthin was almost 0.

The results of the examination of example 10 show that the retention of astaxanthin by the combination of the mastic resin extract and astaxanthin is 59.94. + -. 2.84% on day 30 and 20.39. + -. 3.72% on day 60, as shown in FIG. 11.

The results of the examination of example 11 show that the retention of astaxanthin is 25.74. + -. 2.3 on day 30 and almost 0 on day 45, as shown in FIG. 12, in the combination of tocopherol and astaxanthin.

The results of the examination of example 12 show that the retention of astaxanthin is 62.51 + -3.16% on day 30 and 26.53 + -3.60% on day 60, as shown in FIG. 13, when butylated hydroxytoluene, mastic resin extract and astaxanthin were combined.

The results of the examination of example 13 show that the retention of astaxanthin is 79.82 + -4.29% on day 30 and 57.54 + -4.82% on day 60, as shown in fig. 14 for the combination of butylated hydroxytoluene, tocopherol and astaxanthin.

The results of the examination of example 14 show that the retention of astaxanthin by the combination of the mastic resin extract, tocopherol and astaxanthin is 63.58. + -. 4.18% on day 30 and 27.01. + -. 3.35% on day 60, as shown in FIG. 15.

The results of the examination of example 15 show that the retention of astaxanthin by the combination of the mastic extract, tocopherol and astaxanthin is 81.52 + -4.84% on day 30 and 60.39 + -5.31% on day 60, as shown in fig. 16.

Selecting 30 volunteers, wherein the selection criteria of the volunteers are as follows: all patients had no serious cardiovascular and cerebrovascular diseases and psychological disorders; no nano microneedle sensitivity; no history of insolation before operation; the lips have no skin diseases which influence the observation of curative effect, such as dermatitis, eczema, psoriasis and the like; eliminating lip color change caused by physical diseases; excluding women in lactation and gestation; according to informed consent, the patient is willing to accept nano microneedle treatment and obey the treatment scheme, and can be subjected to double diagnosis.

Using a nano-crystal pen, as shown in fig. 17, performing point-to-point operation according to the numbers 1-5, continuously performing operation in the direction of the numbers 1-5, repeating the operation 5 times, immediately applying lip glaze (lip glaze prepared in example 5) after the operation, applying the lip glaze once every morning and evening every day for 2-7 days, and detecting the color and the lip line of the lip before, after, and after the nano-crystal pen operation.

(1) Lip streak measurement

Photographs were taken with a professional digital camera Nikon MH-31CH and analyzed by the software Photoshop7.0(Adobe System Incorporated, USA). The subject washed his lips with water, sat still for 30min, entered a standard imaging room, and photographed at a fixed position at the eye-closing right position and 45 ° left and right side positions. The obtained pictures were cut by Photoshop tool to obtain the upper and lower lip pictures as the study objects. The intermediate values of the histogram were recorded by analysis with Photoshop software.

Lip wrinkle detection result:

the intermediate value obtained in the Photoshop histogram is the gray value, i.e., the median, corresponding to the pixel point in the image in which 256 pixels are arranged. It reflects how many wrinkles, the larger the value the fewer the wrinkles. Through the analysis of Photoshop7.0 software, compared with data before and after the 7 th day after the operation of the nano microneedle, as shown in FIG. 18, the median of the histogram of the lip veins of the upper lip before the operation is 81.89 + -3.52, the median of the histogram of the lip veins of the upper lip after the operation is 115.78 + -2.64, the median before the operation is improved by about 41%, and the median after the 7 th day after the operation of continuously coating the lip glaze is 110.62 + -4.28, the median before the operation is improved by about 35%; the median of the histogram of the lip veins of the lower lip before operation is 89.23 +/-5.16, the median after operation is 121.68 +/-6.38, which is improved by about 36 percent compared with the median before operation, and the median is 118.43 +/-2.49 after 7 days of continuous lip glaze coating after operation, which is improved by about 32 percent compared with the median before operation. It can be seen that the upper and lower lips were significantly different after the operation from the median of the histogram before the operation, and were still significantly different even though slightly decreased by day seven.

(2) Measurement of lip color

30 subjects washed their lips with clean water, stood still for 30min, entered the test room to start testing, measured at 2 points on each of the left and right sides of the upper and lower lips using a spectrocolorimeter (CM-2600d), and averaged for each of the upper and lower lips.

Lip color detection results:

as shown in fig. 19, after the lip portion was subjected to nano-microneedle operation, the color of both the upper lip and the lower lip was significantly changed, the a value of the upper lip was increased from 15.14 ± 1.03 to 20.45 ± 1.08, which was increased by about 35% compared to the a value before operation, and the a value of the upper lip was 18.86 ± 0.56 after 7 days of using lip glaze after operation, which was increased by about 24% compared to the a value before operation; the lower lip rises from 20.29 plus or minus 0.45 to 24.89 plus or minus 1.29, the a value of the comparative pre-operation is raised by about 22%, and the a value of the lower lip is 23.14 plus or minus 2.12 after 7 days of using the lip glaze composition after the operation, and the a value of the comparative pre-operation is raised by about 14%. It can be seen that the upper and lower lips were significantly different after the operation compared to the a-value before the operation, and the difference was still significant although slightly decreased by the seventh day.

According to the invention, the butylated hydroxytoluene, the boswellia resin extract and the tocopherol are simultaneously added into the lip glaze, so that the color of the astaxanthin is well maintained, the color stability of the composition is further maintained, and a good visual effect is achieved; meanwhile, the color of the astaxanthin is stably maintained, namely the antioxidant effect of the lip glaze is well maintained, and the astaxanthin and other components act together to achieve the effects of removing lip wrinkles and eliminating lip darkness. The nanometer micro-needle dressing can promote wound recovery after micro-needle operation, can promote effective components in lip glaze to permeate into lip skin through micro-needle operation, enhances bioavailability of active components in the lip glaze, and achieves the effects of removing lip wrinkles, eliminating lip darkness and moisturizing under combined action.

While only the preferred embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention.