阅读说明：本技术 固体酶清洗剂及其制备方法 (Solid enzyme cleaning agent and preparation method thereof ) 是由 勾长磊 刘明明 李鹏章 庞元金 韩堃 魏希庆 于 2021-06-25 设计创作，主要内容包括：本发明属于医疗器械用助剂技术领域,具体涉及一种固体酶清洗剂及其制备方法。所述的固体酶清洗剂,由以下重量百分含量的原料组成：固体生物酶25-35％,固体表面活性剂50-60％,固体缓蚀剂5-10％,造粒助剂1-5％。本发明所述的固体酶清洗剂方便储运,手工清洗和机洗通用,原材料安全环保,易于降解；本发明同时提供了简单易行的制备方法。(The invention belongs to the technical field of auxiliary agents for medical instruments, and particularly relates to a solid enzyme cleaning agent and a preparation method thereof. The solid enzyme cleaning agent is composed of the following raw materials in percentage by weight: 25-35% of solid biological enzyme, 50-60% of solid surfactant, 5-10% of solid corrosion inhibitor and 1-5% of granulation auxiliary agent. The solid enzyme cleaning agent is convenient to store and transport, is universal in manual cleaning and machine cleaning, is safe and environment-friendly in raw materials, and is easy to degrade; the invention also provides a simple and feasible preparation method.)

1. A solid enzyme cleaning agent, which is characterized in that: the composite material consists of the following raw materials in percentage by weight:

2. the solid enzyme cleaner according to claim 1, wherein: the composite material consists of the following raw materials in percentage by weight:

3. the solid enzyme cleaner according to claim 1, wherein: the composite material consists of the following raw materials in percentage by weight:

4. the solid enzyme cleaner according to claim 1, wherein: the solid biological enzyme is two or more of solid protease, solid lipase, solid amylase or solid cellulase.

5. The solid enzyme cleaner according to claim 1, wherein: the solid surfactant is one or more of modified polycarboxylate, fatty alcohol-polyoxyethylene ether or fatty acid methyl ester ethoxylate.

6. The solid enzyme cleaner according to claim 1, wherein: the solid corrosion inhibitor is one or two of polycarboxylate or benzotriazole.

7. The solid enzyme cleaner according to claim 1, wherein: the granulation auxiliary agent is one or more of propylene glycol, glycerol or alcohol.

8. A method for preparing a solid enzyme cleaning agent according to any one of claims 1 to 7, which is characterized in that: and crushing and uniformly mixing the solid surfactant and the solid corrosion inhibitor, then adding a granulation auxiliary agent for granulation and shot blasting, drying to obtain a granule mixture, adding the solid biological enzyme into the granule mixture, and uniformly mixing to obtain the solid enzyme cleaning agent.

9. The method for preparing a solid enzyme cleaning agent according to claim 8, wherein the method comprises the following steps: the particle size of the mixture of particles is 0.5-1 mm.

10. The method for preparing a solid enzyme cleaning agent according to claim 8, wherein the method comprises the following steps: adding solid biological enzyme into the granule mixture, and mixing for 40-80 min.

Technical Field

The invention belongs to the technical field of auxiliary agents for medical instruments, and particularly relates to a solid enzyme cleaning agent and a preparation method thereof.

Background

Along with the popularization of the overall supply concept of the hospital disinfection supply center, the CSSD standard is stronger and stronger, and the cleaning quality of medical instruments is more and more emphasized. The cleaning quality of the instruments is a precondition for successful disinfection and sterilization of the instruments. In actual clinical use, common pollutants (such as blood, body fluid, secretion and the like) on the surface of the medical instrument can be cleaned by the multienzyme cleaning agent.

At present, multienzyme cleaning agents used for medical use are all liquid cleaning agents, and the liquid cleaning agents have the advantages of rapid and uniform diffusion, but generally have the defects of unstable enzyme activity and large filling amount, and the problems of high storage, transportation and use costs.

Based on the situation, the solid enzyme cleaning agent for the medical apparatus is developed, and has the advantages of stable enzyme activity, low storage and transportation cost and convenience in use.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: the solid enzyme cleaning agent overcomes the defects of the prior art, is environment-friendly and easily available in raw materials, has a good effect of removing common pollutants of medical instruments, and is convenient to store and transport; the invention also provides a simple and feasible preparation method.

The solid enzyme cleaning agent provided by the invention comprises the following raw materials in percentage by weight:

preferably, the solid enzyme cleaning agent is composed of the following raw materials in percentage by weight:

preferably, the solid enzyme cleaning agent is composed of the following raw materials in percentage by weight:

preferably, the solid biological enzyme is two or more of a solid protease, a solid lipase, a solid amylase or a solid cellulase.

Preferably, the solid surfactant is one or more of modified polycarboxylate, fatty alcohol-polyoxyethylene ether or fatty acid methyl ester ethoxylate.

Preferably, the solid corrosion inhibitor is one or two of polycarboxylate or benzotriazole.

Preferably, the granulation aid is one or more of propylene glycol, glycerol or alcohol.

The preparation method of the solid enzyme cleaning agent comprises the steps of crushing and uniformly mixing the solid surfactant and the solid corrosion inhibitor, then adding the granulation auxiliary agent for granulation and shot blasting, drying to obtain a particle mixture with the particle size of 0.5-1mm, adding the solid biological enzyme into the particle mixture, and mixing for 40-80min to obtain the solid enzyme cleaning agent.

The use method of the solid enzyme cleaning agent comprises the following steps: cleaning water with conventional dosage is put into a cleaning tank of the supply chamber, then the solid enzyme cleaning agent is added according to the proportion of the product specification, and the cleaning agent is slightly stirred, uniformly mixed and dissolved and then put into a polluted apparatus for soaking and manual cleaning. Meanwhile, the solid enzyme cleaning agent can also be matched with special injection equipment to be automatically injected into the full-automatic cleaning sterilizer, and the operation is convenient and simple.

Compared with the prior art, the invention has the following beneficial effects:

(1) the solid enzyme cleaning agent is environment-friendly in raw materials, free of irritation, environment-friendly and easy to degrade.

(2) The solid enzyme cleaning agent is convenient to store and transport, rapid in dissolution and stable in enzyme activity.

(3) The solid enzyme cleaning agent is simple and convenient to operate, and can be used for manual cleaning and machine cleaning in a supply room.

(4) The solid enzyme cleaning agent is used for removing organic pollutants such as protein, fat, starch and the like on the surface of an apparatus, and has good effects of reducing microbial load and removing dirt.

(5) The invention also provides a simple and feasible preparation method of the solid enzyme cleaning agent.

Detailed Description

The present invention is further illustrated by the following examples, which are not intended to limit the practice of the invention.

Example 1

The solid enzyme cleaning agent comprises the following components in percentage by mass:

the solid biological enzyme comprises protease (20%), lipase (5%), amylase (3%) and cellulase (2%), the solid surfactant comprises modified carboxylate (35%), fatty alcohol-polyoxyethylene ether (20%), the solid corrosion inhibitor comprises polycarboxylate (7%), benzotriazole (3%), and the granulation auxiliary agent is propylene glycol (5%).

And crushing and uniformly mixing the solid surfactant and the solid corrosion inhibitor, then adding the auxiliary agent for granulation and shot blasting, and drying to obtain particles with the diameter of 0.5-1 mm. And finally, sequentially adding the solid biological enzyme according to the sequence of protease, lipase, amylase and cellulase, and fully and uniformly mixing for 60min to obtain the solid enzyme cleaning agent.

Example 2

The solid enzyme cleaning agent comprises the following components in percentage by mass:

the solid biological enzyme comprises protease (15%), lipase (5%), amylase (3%) and cellulase (2%), the solid surfactant comprises modified carboxylate (35%), fatty acid methyl ester ethoxylate (25%), the solid corrosion inhibitor comprises polycarboxylate (7%), benzotriazole (3%), and the granulation auxiliary agent is glycerol (5%).

And crushing and uniformly mixing the solid surfactant and the solid corrosion inhibitor, then adding the auxiliary agent for granulation and shot blasting, and drying to obtain particles with the diameter of 0.5-1 mm. And finally, sequentially adding the solid biological enzyme according to the sequence of protease, lipase, amylase and cellulase, and fully and uniformly mixing for 60min to obtain the solid enzyme cleaning agent.

Example 3

The solid enzyme cleaning agent comprises the following components in percentage by mass:

the solid biological enzyme comprises protease (25%), lipase (5%), amylase (3%) and cellulase (2%), the solid surfactant comprises modified carboxylate (25%), fatty acid methyl ester ethoxylate (25%), the solid corrosion inhibitor comprises polycarboxylate (8%), benzotriazole (3%), and the granulation auxiliary agent is alcohol (4%).

And crushing and uniformly mixing the solid surfactant and the solid corrosion inhibitor, then adding the auxiliary agent for granulation and shot blasting, and drying to obtain particles with the diameter of 0.5-1 mm. And finally, sequentially adding the solid biological enzyme according to the sequence of protease, lipase, amylase and cellulase, and fully and uniformly mixing for 60min to obtain the solid enzyme cleaning agent.

Example 4

The solid enzyme cleaning agent comprises the following components in percentage by mass:

the solid biological enzyme comprises protease (15%), lipase (5%), amylase (3%) and cellulase (2%), the solid surfactant comprises modified carboxylate (60%), the solid corrosion inhibitor comprises polycarboxylate (8%), benzotriazole (2%) and the auxiliary agent comprises alcohol (5%).

And crushing and uniformly mixing the solid surfactant and the solid corrosion inhibitor, then adding the auxiliary agent for granulation and shot blasting, and drying to obtain particles with the diameter of 0.5-1 mm. And finally, sequentially adding the solid biological enzyme according to the sequence of protease, lipase, amylase and cellulase, and fully and uniformly mixing for 60min to obtain the solid enzyme cleaning agent.

Example 5

The solid enzyme cleaning agent comprises the following components in percentage by mass:

the solid biological enzyme is protease (20%), lipase (5%), amylase (5%), solid surfactant is modified carboxylate (55%), solid corrosion inhibitor is polycarboxylate (8%), benzotriazole (2%), and assistant is glycerol (5%).

And crushing and uniformly mixing the solid surfactant and the solid corrosion inhibitor, then adding the auxiliary agent for granulation and shot blasting, and drying to obtain particles with the diameter of 0.5-1 mm. And finally, sequentially adding the solid biological enzyme according to the sequence of the protease, the lipase and the amylase according to a specified proportion, and fully and uniformly mixing for 60min to obtain the solid enzyme cleaning agent.

Of course, the foregoing is only a preferred embodiment of the invention and should not be taken as limiting the scope of the embodiments of the invention. The present invention is not limited to the above examples, and equivalent changes and modifications made by those skilled in the art within the spirit and scope of the present invention should be construed as being included in the scope of the present invention.