阅读说明：本技术 用于哺乳动物中的去免疫化志贺毒素a亚基效应子多肽 (Deimmunized Shiga toxin subunit A effector polypeptides for use in mammals ) 是由 埃里克·波马 埃林·威勒特 加勒特·李·鲁滨逊 桑吉萨·拉贾戈帕兰 布丽吉特·布里斯克 于 2015-01-26 设计创作，主要内容包括：本发明涉及具有减少的抗原性和/或免疫原性潜力的志贺毒素效应子多肽。免疫原性可能是向哺乳动物反复施用志贺毒素来源的蛋白和多肽的限制。本发明的志贺毒素效应子多肽具有作为治疗剂、诊断剂和免疫物质的成分的用途。本发明的细胞毒性蛋白具有选择性杀伤特定细胞类似和作为治疗多种疾病的治疗剂的用途,所述疾病包括癌症、免疫病症和微生物感染。本发明的蛋白还具有用于检测特定细胞类型、收集诊断信息和监测多种疾病的治疗的用途,所述疾病诸如例如癌症、免疫病症和微生物感染。(The present invention relates to shiga toxin effector polypeptides having reduced antigenic and/or immunogenic potential. Immunogenicity may be a limitation of repeated administration of shiga toxin-derived proteins and polypeptides to mammals. The shiga toxin effector polypeptides of the present invention have utility as components of therapeutic agents, diagnostic agents, and immunological substances. The cytotoxic proteins of the invention have similar and similar uses as selective killers of specific cells and as therapeutic agents for the treatment of a variety of diseases, including cancer, immune disorders and microbial infections. The proteins of the invention also have uses for detecting specific cell types, collecting diagnostic information, and monitoring treatment of a variety of diseases, such as, for example, cancer, immune disorders, and microbial infections.)