阅读说明：本技术 一种缓释型亮肤精华组合物及其制备方法 (Sustained-release skin-brightening essence composition and preparation method thereof ) 是由 薛永红 夏志宽 曲燕 于 2021-01-26 设计创作，主要内容包括：本发明属于护肤品技术领域,更具体的涉及一种缓释型亮肤精华组合物及其制备方法。一种缓释型亮肤精华组合物,制备原料按重量百分比计,包括：皮肤调理剂5～15、助剂1～10％、溶剂补充余量至100％。本发明中的成膜剂可以将促渗透剂和活性成分充分发挥协同作用,形成包覆型渗透结构,通过各种反应物之间的结合,可以保证渗透持续发生,成膜剂选自三甲基戊二醇/己二酸共聚物,其可以保证功效成分的缓释效果；本发明中使用的促渗透剂可以将本体系中的反应物形成脂质体包覆结构,为渗透作用的发生提供基础。(The invention belongs to the technical field of skin care products, and particularly relates to a slow-release skin brightening essence composition and a preparation method thereof. The sustained-release skin-brightening essence composition comprises the following raw materials in percentage by weight: 5-15% of a skin conditioner, 1-10% of an auxiliary agent and the balance of a solvent to 100%. The film forming agent can fully exert the synergistic effect of the penetration enhancer and the active ingredients to form a coating type penetration structure, the continuous penetration can be ensured by the combination of various reactants, and the film forming agent is selected from a trimethyl pentanediol/adipic acid copolymer and can ensure the slow release effect of the effective ingredients; the penetration enhancer used in the invention can form liposome coating structure for the reactants in the system, and provides a foundation for the occurrence of penetration.)

1. The slow-release skin brightening essence composition is characterized by comprising the following preparation raw materials in percentage by weight: 5-15% of a skin conditioner, 1-10% of an auxiliary agent and the balance of a solvent to 100%.

2. The sustained-release skin-lightening essence composition according to claim 1, wherein the solvent comprises water and/or 1, 3-propanediol.

3. The sustained-release skin-brightening essence composition according to claim 2, wherein the 1, 3-propanediol is 0.1-1% by weight.

4. The sustained-release skin-lightening essence composition according to claim 1, wherein the skin conditioner comprises: allantoin, hydrolyzed hyaluronic acid, 1, 2-pentanediol, glutathione, HCl-containing compounds, cyanocobalamin, taurine, asparagine, methionine, cystine, biotin, hydroxyproline, methionine diphosphonate, inositol, plant extracts, an active ingredient A, an active ingredient B and an active ingredient C.

5. The sustained-release skin lightening essence composition according to claim 4, wherein the HCl-containing compound is at least one selected from the group consisting of lysine HCl, arginine HCl, ornithine HCl, pyridoxine HCl, chitosamine HCl, and histidine HCl.

6. The sustained-release skin-lightening essence composition according to claim 4, wherein the plant extract is selected from one or more of neem leaf extract, coral algae extract, solanum solanaceous fruit extract, aloe barbadensis flower extract, and holy basil leaf extract.

7. The sustained-release skin-lightening essence composition according to claim 4, wherein the active ingredient A is an amino acid compound; the active component B is a Chondrus crispus extract; the active component C is a compound containing a bright white component.

8. The sustained-release skin-lightening essence composition according to claim 1, wherein the auxiliary agent is one or more selected from a thickening agent, a film-forming agent, a preservative, and a penetration enhancer.

9. The sustained-release skin-brightening essence composition according to claim 8, wherein the weight percentage of the thickener is 0.3-1%; 2-3% of film-forming agent, 0.1-1% of preservative and 1-5% of penetration enhancer.

10. The preparation method of the sustained-release skin-brightening essence composition according to any one of claims 1 to 9, characterized by comprising the following steps:

1) weighing a solvent, a skin conditioner and an auxiliary agent according to the weight percentage, adding the weighed materials into a vacuum stirring pot, and stirring to obtain a mixture;

2) discharging the mixture obtained in the step 1) through vacuum defoaming;

3) standing and aging to obtain the product.

Technical Field

The invention belongs to the technical field of skin care products, and particularly relates to a slow-release skin brightening essence composition and a preparation method thereof.

Background

With the popularization and application of skin care products, the development of the skin care products presents a rapid development state. Skin care products with different efficacies, such as whitening, moisturizing, freckle removing, wrinkle removing, anti-aging and skin brightening appear on the market, but with the improvement of the requirements of people on the efficacies, skin care products containing harmful components such as hormone, lead and mercury also appear, the skin care products have dependence, and once the skin care products are not used, various problems of the skin can appear.

The improvement of living standard of people inevitably increases the requirements on skin care products, and particularly, the requirements on the skin care products for daily care such as moisturizing, whitening and skin brightening are higher and higher. The improvement of the quality of the skin care product inevitably leads to the increase of the cost, but the cost is improved, and meanwhile, if the quality, the efficacy and even the action time can be greatly improved, the product cost is naturally reduced. In the skin care products at the present stage, the effect of long-acting release cannot be achieved only by adding active ingredients.

In the face of the development of the current skin care products, the production and preparation of the skin care product with lasting skin care time and prolonged active ingredient action time becomes the demand of a new era.

Disclosure of Invention

In order to solve the technical problems, the first aspect of the present invention provides a sustained-release skin-brightening essence composition, which comprises the following raw materials by weight: 5-15% of a skin conditioner, 1-10% of an auxiliary agent and the balance of a solvent to 100%.

As a preferred technical scheme, the solvent comprises water and/or 1, 3-propylene glycol.

As a preferable technical scheme, the weight percentage of the 1, 3-propylene glycol is 0.1-1%.

As a preferred embodiment, the skin conditioner comprises: allantoin, hydrolyzed hyaluronic acid, 1, 2-pentanediol, glutathione, HCl-containing compounds, cyanocobalamin, taurine, asparagine, methionine, cystine, biotin, hydroxyproline, methionine diphosphonate, inositol, plant extracts, an active ingredient A, an active ingredient B and an active ingredient C.

In a preferred embodiment, the HCl-containing compound is at least one selected from the group consisting of lysine HCl, arginine HCl, ornithine HCl, pyridoxine HCl, chitosamine HCl, and histidine HCl.

As a preferable technical scheme, the plant extract is selected from one or more of neem leaf extract, coral grass extract, solanum lyratum fruit extract, aloe barbadensis flower extract and holy basil leaf extract.

As a preferable technical scheme, the active ingredient A is an amino acid compound; the active component B is a Chondrus crispus extract; the active component C is a compound containing a bright white component.

As a preferable technical scheme, the auxiliary agent is selected from one or more of thickening agent, film forming agent, preservative and penetration enhancer.

As a preferred technical scheme, the weight percentage of the thickening agent is 0.3-1%; 2-3% of film-forming agent, 0.1-1% of preservative and 1-5% of penetration enhancer.

The second aspect of the invention provides a preparation method of a sustained-release skin-brightening essence composition, which comprises the following steps:

1) weighing a solvent, a skin conditioner and an auxiliary agent according to the weight percentage, adding the weighed materials into a vacuum stirring pot, and stirring to obtain a mixture;

2) discharging the mixture obtained in the step 1) through vacuum defoaming;

3) standing and aging to obtain the product.

Has the advantages that: the slow-release skin-brightening essence composition prepared by the invention has the following advantages:

1. the film forming agent can fully exert the synergistic effect of the penetration enhancer and the active ingredients to form a coating type penetration structure, the continuous penetration can be ensured by the combination of various reactants, and the film forming agent is selected from a trimethyl pentanediol/adipic acid copolymer and can ensure the slow release effect of the effective ingredients;

2. in the invention, the active ingredient can be directly and continuously input into the cells through the mutual attraction between the active ingredient A of the specific skin conditioner and the skin cell receptor, thereby ensuring that the active ingredient can achieve the excellent skin brightening effect with extremely low dosage;

3. the penetration enhancer used in the invention can form liposome coating structure for the reactants in the system, and provides a foundation for the occurrence of penetration.

Detailed Description

The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.

The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.

The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.

When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.

The singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. "optional" or "any" means that the subsequently described event or events may or may not occur, and that the description includes instances where the event occurs and instances where it does not.

Approximating language, as used herein throughout the specification and claims, is intended to modify a quantity, such that the invention is not limited to the specific quantity, but includes portions that are literally received for modification without substantial change in the basic function to which the invention is related. Accordingly, the use of "about" to modify a numerical value means that the invention is not limited to the precise value. In some instances, the approximating language may correspond to the precision of an instrument for measuring the value. In the present description and claims, range limitations may be combined and/or interchanged, including all sub-ranges contained therein if not otherwise stated.

In addition, the indefinite articles "a" and "an" preceding an element or component of the invention are not intended to limit the number requirement (i.e., the number of occurrences) of the element or component. Thus, "a" or "an" should be read to include one or at least one, and the singular form of an element or component also includes the plural unless the stated number clearly indicates that the singular form is intended.

In order to solve the above problems, a first aspect of the present invention provides a sustained-release skin-lightening essence composition, which comprises the following raw materials by weight: 5-15% of a skin conditioner, 1-10% of an auxiliary agent and the balance of a solvent to 100%.

In some preferred embodiments, the solvent comprises water and/or 1, 3-propanediol.

In some preferred embodiments, the 1, 3-propanediol is present in an amount of 0.1 to 1% by weight.

In some preferred embodiments, the 1, 3-propanediol is present at 0.5% by weight.

In some preferred embodiments, the skin conditioning agent comprises: allantoin, hydrolyzed hyaluronic acid, 1, 2-pentanediol, glutathione, HCl-containing compounds, cyanocobalamin, taurine, asparagine, methionine, cystine, biotin, hydroxyproline, methionine diphosphonate, inositol, plant extracts, an active ingredient A, an active ingredient B and an active ingredient C.

In some preferred embodiments, the weight ratio of active ingredient a, active ingredient B, active ingredient C is 1: 1.5-2.5: 2 to 3.

In some preferred embodiments, the weight ratio of active ingredient a, active ingredient B, active ingredient C is 1: 2: 2.5.

in the experimental process, the applicant finds that the active ingredients A, B and C are in the weight range, so that the effective ingredients can be fully released, and the release speed is guaranteed. The applicant speculates that possible reasons are: the active component A contains a plurality of amino acids, and micro-crosslinking state can be formed between the amino acids and the active components in the active component C, so that the active component B and other active components in the system can be embedded into the active component A, reaction conditions are provided for the active components, and the formation of a coating structure in the whole system is promoted; the applicant unexpectedly finds that the interaction of the three substances also improves the whitening effect of the skin-brightening essence, and the applicant believes that the whitening effect is achieved by inhibiting the generation of melanin by the neuraminidase due to the capability of inhibiting the neuraminidase mechanism in the active ingredients.

In some preferred embodiments, the HCl-containing compound is selected from at least one of lysine HCl, arginine HCl, ornithine HCl, pyridoxine HCl, chitosamine HCl, histidine HCl.

In some preferred embodiments, the HCl-containing compound comprises, in weight percent: lysine HCl 0.000006-0.000008%, arginine HCl 0.000006-0.000008%, ornithine HCl0.000003-0.000005%, pyridoxine HCl 0.000002-0.000004%, chitosamine HCl0.000001-0.000003%, histidine HCl 0.000001-0.000003%.

In some preferred embodiments, the plant extract is selected from one or more of neem leaf extract, coral algae extract, solanum berry extract, aloe barbadensis flower extract, and holy basil leaf extract.

In some preferred embodiments, the weight percentage of the plant extract is: 0.015-0.025% of neem leaf extract, 0.01-0.02% of coral algae extract, 0.005-0.012% of solanum lyratum fruit extract, 0.0045-0.006% of aloe barbadensis flower extract, and 0.003-0.005% of holy basil leaf extract.

Neem leaf extract

Neem leaf extract, INCI: AZADIRACHTA INDICA LEAF EXTRACT.

Coral algae extract

Coral algae extract, INCI: CORALLINA OFFICINALIS EXTRACT.

Solanum melongena extract

Solanum melongena extract, INCI: SOLANUM MELONGENNA (EGGPLANT) FRUIT EXTRACT.

Aloe barbadensis flower extract

Aloe barbadensis flower extract, INCI: ALOE BARBADENSIS FLOWER EXTRACT.

Extract of holy basil leaves

Holy basil leaf extract, INCI: OCIMUM SANCTUM LEAF EXTRACT.

In some preferred embodiments, the active ingredient a is an amino acid complex; the active component B is a Chondrus crispus extract; the active component C is a compound containing a bright white component.

In some preferred embodiments, the amino acid-based complex described in active ingredient a comprises: serine, alanine, aspartic acid, glutamine, isoleucine, leucine, arginine, glutamic acid, glycine, histidine, lysine, phenylalanine, proline, tryptophan, tyrosine, valine.

In some preferred embodiments, the active ingredient C comprises alpha-arbutin, polysorbate-80 and resveratrol.

Active ingredient a, model X50, available from Infinitec, spain; active ingredient B was oligiogel PF, available from sibirak corporation; active ingredient C was SalSphere Light, available from SALVONA, usa.

In some preferred embodiments, the auxiliary agent is selected from one or more of thickening agent, film forming agent, preservative and penetration enhancer.

In some preferred embodiments, the thickener is at least one selected from the group consisting of sodium carboxymethylcellulose, chitosan, sodium alginate, and sodium polyacrylate.

In some preferred embodiments, the thickener is selected from sodium polyacrylate (CAS: 9003-04-7).

In some preferred embodiments, the film former is selected from at least one of polyvinylpyrrolidone/hexadecene copolymer, trimethylsiloxysilicate, acrylic resin and dimethylsiloxane copolymer, acrylate/octylacrylamide copolymer, polyvinyl alcohol, trimethylpentanediol/adipic acid copolymer.

In some preferred embodiments, the film former is selected from trimethylpentanediol/adipic acid copolymer (CAS: 26139-53-7).

In some preferred embodiments, the preservative comprises caprylhydroxamic acid, ethylhexylglycerin, methylpropanediol, caprylhydroxamic acid.

The preservative was Serasafe H, available from GANA biopharmaceutical corporation, korea.

In some preferred embodiments, the penetration enhancer comprises: lecithin, tocopherol, sunflower seed oil.

The penetration enhancer used in this application was Pro-Lipo Neo, available from Lucas Meyer cosmetics.

In some preferred embodiments, the weight percentage of the thickener is 0.3-1%; 2-3% of film-forming agent, 0.1-1% of preservative and 1-5% of penetration enhancer.

In some preferred embodiments, the weight ratio of the film-forming agent to the penetration enhancer is 1: 1 to 2.

In some preferred embodiments, the weight ratio of the film-forming agent to the penetration enhancer is 1: 1.2.

in the course of the experiments the applicant found that the skin conditioning agents and adjuvants selected in the present invention were based on achieving a sustained release effect. The applicant proves that the penetration enhancer selected by the invention can form a liposome coating structure through a large amount of creative experimental researches, and the weight ratio of the film-forming agent trimethylpentanediol/adipic acid copolymer to the penetration enhancer is 1: 1-2, skin conditioner components in the system can be integrated into a coating structure formed by a penetration enhancer through a synergistic effect, and the formed coating structure can be ensured to slowly permeate and act on skin cells through the penetration effect under the promotion of an active component C; on the other hand, due to the slow release and lasting effect of the active ingredients, the action time of the active ingredients on the skin is prolonged, the skin is further protected and moistened, and the skin brightening effect is achieved.

In the experimental test process, the applicant finds that the sustained-release skin-brightening essence composition prepared by the method has a skin-brightening effect on skin, can protect the skin from the influence of pollution particles in the environment, forms a protective physical barrier on the surface of the skin, prevents harmful substances from adhering to the surface of the skin, and further improves the skin-brightening effect.

In the experimental process, the applicant finds that the dosage of the film forming agent is larger than the range of the application, so that the prepared composition has sticky feeling and slight irritation to the skin; when the dosage of the penetration enhancer is too large, the time for the effective components to act on the face is shortened, and the slow release effect is reduced.

The second aspect of the invention provides a preparation method of a sustained-release skin-brightening essence composition, which comprises the following steps:

1) weighing a solvent, a skin conditioner and an auxiliary agent according to the weight percentage, adding the weighed materials into a vacuum stirring pot, and stirring to obtain a mixture;

2) discharging the mixture obtained in the step 1) through vacuum defoaming;

3) standing and aging to obtain the product.

The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.

In addition, the starting materials used are all commercially available, unless otherwise specified.

Examples

Example 1

The sustained-release skin-brightening essence composition comprises the following raw materials in percentage by weight: allantoin 0.15%, hydrolyzed hyaluronic acid 0.1%, sodium polyacrylate 0.6%, trimethylpentanediol/adipic acid copolymer 2.5%, 1, 2-pentanediol 3%, preservative 0.5%, 1, 3-propanediol 0.5%, active ingredient A1%, permeation enhancer 3%, active ingredient B2%, active ingredient C2.5%, glutathione 0.000008%, cyanocobalamin 0.000005%, taurine 0.000005%, asparagine 0.000005%, methionine 0.000004%, cystine 0.000003%, biotin 0.000003%, hydroxyproline 0.000003%, methionine diphosphonate 0.000002%, inositol 0.000001%, lysine HCl 0.000007%, arginine HCl 0.000007%, ornithine HCl 0.000004%, pyridoxine HCl 0.000003%, chitosamine HCl 0.000002%, histidine HCl 0.000002%, Azadirachta indica leaf extract 0.013%, Solanum algae extract 0.008%, Aloe vera flower extract 0.0050.5%, Aloe flower extract 0.00005%, Hu sugar amine HCl 0.000002%, histidine HCl 0.000002%, and so on, The extract of the holy basil leaf is 0.0035 percent, and the balance is water to 100 percent.

The active component A is an amino acid compound, and the amino acid compound comprises: serine, alanine, aspartic acid, glutamine, isoleucine, leucine, arginine, glutamic acid, glycine, histidine, lysine, phenylalanine, proline, tryptophan, tyrosine, valine.

The active component B is Chondrus crispus extract.

The active ingredient C is a compound containing a brightening component, and comprises alpha-arbutin, polysorbate-80 and resveratrol.

Active ingredient a, model X50, available from Infinitec, spain; active ingredient B was oligiogel PF, available from sibirak corporation; active ingredient C was SalSphere Light, available from SALVONA, usa; sodium polyacrylate (CAS: 9003-04-7); trimethylpentanediol/adipic acid copolymer (CAS: 26139-53-7); the preservative was Serasafe H, available from GANA biopharmaceutical corporation, korea; the penetration enhancer is Pro-Lipo Neo, purchased from Lucas Meyer cosmetics company; neem leaf extract, available from calipo cosmetics, singapore; corallinum japonicum extract, purchased from calipo cosmetics, singapore; solanum melongena extract, available from Campo cosmetics, Inc; aloe barbadensis flower extract, available from Campo cosmetics, Inc. of Singapore; ocimum sanctum leaf extract, available from Campo cosmetics, California, Singapore.

A preparation method of a sustained-release skin-brightening essence composition comprises the following steps:

1) weighing a solvent, a skin conditioner and an auxiliary agent according to the weight percentage, adding the weighed materials into a vacuum stirring pot, and stirring to obtain a mixture;

2) discharging the mixture obtained in the step 1) through vacuum defoaming;

3) standing and aging to obtain the product.

Example 2

The sustained-release skin-brightening essence composition comprises the following raw materials in percentage by weight: allantoin 0.15%, hydrolyzed hyaluronic acid 0.1%, sodium polyacrylate 0.6%, trimethylpentanediol/adipic acid copolymer 2.5%, 1, 2-pentanediol 3%, preservative 0.5%, 1, 3-propanediol 0.5%, active ingredient A1%, permeation enhancer 3%, active ingredient B2%, active ingredient C2.5%, glutathione 0.000008%, cyanocobalamin 0.000005%, taurine 0.000005%, asparagine 0.000005%, methionine 0.000004%, cystine 0.000003%, biotin 0.000003%, hydroxyproline 0.000003%, methionine diphosphonate 0.000002%, inositol 0.000001%, lysine HCl 0.000006%, arginine HCl 0.000006%, ornithine HCl 0.000003%, pyridoxine HCl 0.000002%, chitosamine HCl 0.000001%, histidine HCl 0.000001%, Azadirachta indica leaf extract 0.015%, Solanum algae extract 0.01%, Solanum extract 0.005%, Aloe vera flower extract 0.5%, Glycine, The extract of the holy basil leaves is 0.003 percent, and the balance is water to 100 percent.

The active component A is an amino acid compound, and the amino acid compound comprises: serine, alanine, aspartic acid, glutamine, isoleucine, leucine, arginine, glutamic acid, glycine, histidine, lysine, phenylalanine, proline, tryptophan, tyrosine, valine.

The active component B is Chondrus crispus extract.

The active ingredient C is a compound containing a brightening component, and comprises alpha-arbutin, polysorbate-80 and resveratrol.

Active ingredient a, model X50, available from Infinitec, spain; active ingredient B was oligiogel PF, available from sibirak corporation; active ingredient C was SalSphere Light, available from SALVONA, usa; sodium polyacrylate (CAS: 9003-04-7); trimethylpentanediol/adipic acid copolymer (CAS: 26139-53-7); the preservative was Serasafe H, available from GANA biopharmaceutical corporation, korea; the penetration enhancer is Pro-Lipo Neo, purchased from Lucas Meyer cosmetics company; neem leaf extract, available from calipo cosmetics, singapore; corallinum japonicum extract, purchased from calipo cosmetics, singapore; solanum melongena extract, available from Campo cosmetics, Inc; aloe barbadensis flower extract, available from Campo cosmetics, Inc. of Singapore; ocimum sanctum leaf extract, available from Campo cosmetics, California, Singapore.

A method for preparing a sustained-release skin-brightening essence composition according to example 1.

Example 3

The sustained-release skin-brightening essence composition comprises the following raw materials in percentage by weight: allantoin 0.15%, hydrolyzed hyaluronic acid 0.1%, sodium polyacrylate 0.6%, trimethylpentanediol/adipic acid copolymer 2.5%, 1, 2-pentanediol 3%, preservative 0.5%, 1, 3-propanediol 0.5%, active ingredient A1%, permeation enhancer 3%, active ingredient B2%, active ingredient C2.5%, glutathione 0.000008%, cyanocobalamin 0.000005%, taurine 0.000005%, asparagine 0.000005%, methionine 0.000004%, cystine 0.000003%, biotin 0.000003%, hydroxyproline 0.000003%, methionine diphosphonate 0.000002%, inositol 0.000001%, lysine HCl 0.000008%, arginine HCl 0.000008%, ornithine HCl 0.000005%, pyridoxine HCl 0.000004%, chitosamine HCl 0.000003%, histidine HCl 0.000003%, Azadirachta indica leaf extract 0.025%, Solanum algae extract 0.02%, Solanum extract 0.012%, Aloe flower extract 0.006%, Huo-Guo-Miao extract 0.006%, (S-K), The extract of the holy basil leaves is 0.005%, and the balance is water to 100%.

The active component A is an amino acid compound, and the amino acid compound comprises: serine, alanine, aspartic acid, glutamine, isoleucine, leucine, arginine, glutamic acid, glycine, histidine, lysine, phenylalanine, proline, tryptophan, tyrosine, valine.

The active component B is Chondrus crispus extract.

The active ingredient C is a compound containing a brightening component, and comprises alpha-arbutin, polysorbate-80 and resveratrol.

Active ingredient a, model X50, available from Infinitec, spain; active ingredient B was oligiogel PF, available from sibirak corporation; active ingredient C was SalSphere Light, available from SALVONA, usa; sodium polyacrylate (CAS: 9003-04-7); trimethylpentanediol/adipic acid copolymer (CAS: 26139-53-7); the preservative was Serasafe H, available from GANA biopharmaceutical corporation, korea; the penetration enhancer is Pro-Lipo Neo, purchased from Lucas Meyer cosmetics company; neem leaf extract, available from calipo cosmetics, singapore; corallinum japonicum extract, purchased from calipo cosmetics, singapore; solanum melongena extract, available from Campo cosmetics, Inc; aloe barbadensis flower extract, available from Campo cosmetics, Inc. of Singapore; ocimum sanctum leaf extract, available from Campo cosmetics, California, Singapore.

A method for preparing a sustained-release skin-brightening essence composition according to example 1.

Example 4

The sustained-release skin-brightening essence composition comprises the following raw materials in percentage by weight: allantoin 0.15%, hydrolyzed hyaluronic acid 0.1%, sodium polyacrylate 0.6%, trimethylpentanediol/adipic acid copolymer 2.5%, 1, 2-pentanediol 3%, preservative 0.5%, 1, 3-propanediol 0.5%, active ingredient A1%, penetration enhancer 0.25%, active ingredient B2%, active ingredient C2.5%, glutathione 0.000008%, cyanocobalamin 0.000005%, taurine 0.0000048%, asparagine 0.0000046%, methionine 0.0000036%, cystine 0.0000032%, biotin 0.0000028%, hydroxyproline 0.0000025%, methionine diphosphonate 0.0000016%, inositol 0.0000011%, lysine HCl 0.000008%, arginine HCl 0.0000075%, ornithine HCl 0.000004%, pyridoxine HCl 0.000003%, chitosamine HCl 0.0000025%, histidine HCl 0.0000024%, neem leaf extract 0.025%, sarcandra glabra extract 0.02%, solanum fruit extract 0.012%, aloe barbadensis extract 0.006%, flower extract 0.006%, and the like, The extract of the holy basil leaves is 0.005%, and the balance is water to 100%.

The active component A is an amino acid compound, and the amino acid compound comprises: serine, alanine, aspartic acid, glutamine, isoleucine, leucine, arginine, glutamic acid, glycine, histidine, lysine, phenylalanine, proline, tryptophan, tyrosine, valine.

The active component B is Chondrus crispus extract.

The active ingredient C is a compound containing a brightening component, and comprises alpha-arbutin, polysorbate-80 and resveratrol.

Active ingredient a, model X50, available from Infinitec, spain; active ingredient B was oligiogel PF, available from sibirak corporation; active ingredient C was SalSphere Light, available from SALVONA, usa; sodium polyacrylate (CAS: 9003-04-7); trimethylpentanediol/adipic acid copolymer (CAS: 26139-53-7); the preservative was Serasafe H, available from GANA biopharmaceutical corporation, korea; the penetration enhancer is Pro-Lipo Neo, purchased from Lucas Meyer cosmetics company; neem leaf extract, available from calipo cosmetics, singapore; corallinum japonicum extract, purchased from calipo cosmetics, singapore; solanum melongena extract, available from Campo cosmetics, Inc; aloe barbadensis flower extract, available from Campo cosmetics, Inc. of Singapore; ocimum sanctum leaf extract, available from Campo cosmetics, California, Singapore.

A method for preparing a sustained-release skin-brightening essence composition according to example 1.

Example 5

The sustained-release skin-brightening essence composition comprises the following raw materials in percentage by weight: allantoin 0.15%, hydrolyzed hyaluronic acid 0.1%, sodium polyacrylate 0.6%, trimethylpentanediol/adipic acid copolymer 2.5%, 1, 2-pentanediol 3%, preservative 0.5%, 1, 3-propanediol 0.5%, active ingredient A1%, permeation enhancer 12.5%, active ingredient B2%, active ingredient C2.5%, glutathione 0.000008%, cyanocobalamin 0.000005%, taurine 0.0000048%, asparagine 0.0000046%, methionine 0.0000036%, cystine 0.0000032%, biotin 0.0000028%, hydroxyproline 0.0000025%, methionine diphosphonate 0.0000016%, inositol 0.0000011%, lysine HCl 0.0000073%, arginine HCl 0.000007%, ornithine HCl 0.0000039%, pyridoxine HCl 0.0000026%, shell HCl 0.0000022%, histidine HCl 0.000002%, neem leaf extract 0.02%, sargassum glabrum extract 0.013%, solanum fruit extract 0.008%, aloe vera flower extract 0.0055%, sodium hyaluronate extract, The extract of the holy basil leaf is 0.0035 percent, and the balance is water to 100 percent.

The active component A is an amino acid compound, and the amino acid compound comprises: serine, alanine, aspartic acid, glutamine, isoleucine, leucine, arginine, glutamic acid, glycine, histidine, lysine, phenylalanine, proline, tryptophan, tyrosine, valine.

The active component B is Chondrus crispus extract.

The active ingredient C is a compound containing a brightening component, and comprises alpha-arbutin, polysorbate-80 and resveratrol.

Active ingredient a, model X50, available from Infinitec, spain; active ingredient B was oligiogel PF, available from sibirak corporation; active ingredient C was SalSphere Light, available from SALVONA, usa; sodium polyacrylate (CAS: 9003-04-7); trimethylpentanediol/adipic acid copolymer (CAS: 26139-53-7); the preservative was Serasafe H, available from GANA biopharmaceutical corporation, korea; the penetration enhancer is Pro-Lipo Neo, purchased from Lucas Meyer cosmetics company; neem leaf extract, available from calipo cosmetics, singapore; corallinum japonicum extract, purchased from calipo cosmetics, singapore; solanum melongena extract, available from Campo cosmetics, Inc; aloe barbadensis flower extract, available from Campo cosmetics, Inc. of Singapore; ocimum sanctum leaf extract, available from Campo cosmetics, California, Singapore.

A method for preparing a sustained-release skin-brightening essence composition according to example 1.

EXAMPLE 6

The embodiment of the sustained-release skin brightening essence composition is the same as that of example 1, and is different from example 1 in that 1, 3-propanediol is not contained.

Example 7

The embodiment of the sustained-release skin-brightening essence composition is the same as that of example 1, and is different from example 1 in that the composition does not contain the active ingredient A.

Example 8

The embodiment of the sustained-release skin brightening essence composition is the same as that of example 1, and is different from example 1 in that the composition does not contain an active ingredient C.

Example 9

The embodiment of the slow-release skin brightening essence composition is the same as that in example 1, and is different from example 1 in that the weight ratio of an active ingredient A to an active ingredient B to an active ingredient C is 1: 1: 1.

example 10

The specific implementation mode of the sustained-release skin-brightening essence composition is the same as that in example 1, and the difference from example 1 is that a film-forming agent is polyvinyl alcohol which is purchased from Shanghai Aladdin Biochemical reagent company Limited.

Example 11

The embodiment of the slow-release type skin brightening essence composition is the same as that of example 1, and is different from example 1 in that the composition does not contain a penetration enhancer.

And (3) performance testing:

1. and (3) testing the slow release effect: the sustained-release effect test is carried out on the sustained-release type skin brightening essence composition prepared in the example 1 and the common commercially available skin brightening and purifying composition, 20 female volunteers aged 25-40 years are randomly selected and randomly divided into two groups, so that the volunteers score the skin brightening and purifying composition under different trial conditions, and the score of the skin brightening and purifying composition with the obvious skin color brightening effect is 9-10; slightly improving the skin color and marking the result as 5-9 points; the effect of lightening the skin color is not found and is marked as 1-5 points, and the results are counted in the following table 1.

Table 1:

2. and (3) testing the melanin content: the skin melanin content of the skin of the volunteers after the use of the sustained-release type skin lightening essence compositions prepared in examples 1 to 11 was tested by a Mexameter MX18 instrument, and the test results were counted in the following table 2.

90 female volunteers aged 25-40 years were randomly selected, randomly divided into nine groups, and the change in the melanin content in the face of the volunteer before use and after 7 days and 30 days was tested.

Note: the data are the average of melanin in each group of volunteers.

Table 2:

the above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.