Cosmetic for repairing skin barrier and preparation method thereof
阅读说明：本技术 一种用于修复皮肤屏障的化妆品及其制备方法 (Cosmetic for repairing skin barrier and preparation method thereof ) 是由 黄少华 张碧华 周邦华 于 2021-02-10 设计创作，主要内容包括：本发明公开一种用于修复皮肤屏障的化妆品及其制备方法,包括以下质量份的组份：水,甘油,丁二醇,EDTA二钠份,汉生胶,赤藓糖醇,重均分子量为100万-130万道尔顿的透明质酸钠,重均分子量为180万-200万道尔顿的透明质酸钠,重均分子量为5000-10000道尔顿的透明质酸钠,甜菜碱,烟酰胺；C14-22醇、C12-20烷基葡糖苷的混合物,甘油硬脂酸酯、PEG-100硬脂酸酯的混合物,牛油果树果脂油,鲸蜡硬脂醇,棕榈酸乙基己酯,白池花籽油、植物鞘氨醇、神经酰胺3、氢化卵磷脂的混合物,聚二甲基硅氧烷,氢化聚癸烯,异壬酸异壬酯；碳酸二辛酯,1,2-己二醇,对羟基苯乙酮；精氨酸的水溶液；糖类同分异构体,纤连蛋白,新疆筋骨草提取物,香精；纤连蛋白的重均分子量为40-80KDA。它能改善皮肤新陈代谢功能,促进人体天然屏障(皮脂膜)的形成,修复受损皮肤屏障,同时为加快人体皮脂膜形成,模拟人体自身皮脂对于肌肤的保湿作用保护作用和交换作用,赋予额外一层保护膜。(The invention discloses a cosmetic for repairing skin barriers and a preparation method thereof, wherein the cosmetic comprises the following components in parts by mass: water, glycerol, butanediol, EDTA disodium, xanthan gum, erythritol, sodium hyaluronate with the weight average molecular weight of 100-130 ten thousand daltons, sodium hyaluronate with the weight average molecular weight of 180-200 ten thousand daltons, sodium hyaluronate with the weight average molecular weight of 5000-10000 daltons, betaine and nicotinamide; a mixture of C14-22 alcohols, C12-20 alkyl glucosides, glyceryl stearate, a mixture of PEG-100 stearate, shea butter, cetostearyl alcohol, ethylhexyl palmitate, meadowfoam seed oil, phytosphingosine, ceramide 3, a mixture of hydrogenated lecithins, polydimethylsiloxane, hydrogenated polydecene, isononyl isononanoate; dioctyl carbonate, 1, 2-hexanediol, p-hydroxyacetophenone; an aqueous solution of arginine; saccharide isomerate, fibronectin, an extract of Ajuga Xinjiang, and essence; the weight average molecular weight of fibronectin is 40-80 KDA. The skin care product can improve the metabolism function of skin, promote the formation of a natural barrier (sebum membrane) of a human body, repair a damaged skin barrier, and endow an additional layer of protective membrane for accelerating the formation of the sebum membrane of the human body and simulating the moisturizing effect and the exchange effect of the sebum of the human body on the skin.)
1. The cosmetic for repairing the skin barrier is characterized by comprising the following components in parts by mass:
46.988-70.313 parts of water, 5.600-10.000 parts of glycerol, 2.100-3.750 parts of butanediol, 0.021-0.038 part of EDTA disodium, 0.070-0.125 part of xanthan gum, 0.350-0.625 part of erythritol, 0.021-0.038 part of sodium hyaluronate with the weight average molecular weight of 100-130 ten thousand daltons, 0.021-0.038 part of sodium hyaluronate with the weight average molecular weight of 180-200 ten thousand daltons, 0.035-0.063 part of sodium hyaluronate with the weight average molecular weight of 5000-10000 daltons, 0.350-0.625 part of betaine and 0.700-1.250 parts of nicotinamide;
0.700-1.250 parts of a mixture of C14-22 alcohol and C12-20 alkyl glucoside, 0.350-0.625 part of a mixture of glyceryl stearate and PEG-100 stearate, 0.700-1.250 parts of shea butter, 0.280-0.500 part of cetostearyl alcohol, 1.400-2.500 parts of ethylhexyl palmitate, 2.800-5.000 parts of a mixture of white meadowfoam seed oil, phytosphingosine, ceramide 3 and hydrogenated lecithin, 0.700-1.250 parts of polydimethylsiloxane, 2.100-3.750 parts of hydrogenated polydecene and 2.100-3.750 parts of isononyl isononanoate;
1.400-2.500 parts of dioctyl carbonate, 0.350-0.625 part of 1, 2-hexanediol and 0.350-0.625 part of p-hydroxyacetophenone;
1.400-2.500 parts of water and 0.070-0.125 part of arginine;
0.105-0.188 parts of saccharide isomerate, 2.100-3.750 parts of fibronectin, 3.500-6.250 parts of Xinjiang carpet bugle extract and 0.014-0.025 parts of essence;
wherein the weight average molecular weight of fibronectin is 40-80 KDA.
2. The cosmetic for repairing a skin barrier according to claim 1, wherein the mixture of C14-22 alcohol and C12-20 alkyl glucoside has a C14-22 alcohol content of 25% and a C12-20 alkyl glucoside content of 75% in terms of the total mass percentage of the mixture of C14-22 alcohol and C12-20 alkyl glucoside.
3. The cosmetic for repairing skin barrier according to claim 1, wherein the mixture of glyceryl stearate and PEG-100 stearate comprises 50% of glyceryl stearate and 50% of PEG-100 stearate, based on the total mass percentage of the mixture of glyceryl stearate and PEG-100 stearate.
4. The cosmetic for repairing skin barrier according to claim 1, wherein the mixture of meadowfoam seed oil, phytosphingosine, ceramide 3 and hydrogenated lecithin comprises, in terms of the total mass percentage of the mixture of meadowfoam seed oil, phytosphingosine, ceramide 3 and hydrogenated lecithin, 20% of meadowfoam seed oil, 4% of phytosphingosine, 5% of ceramide 3, 2% of hydrogenated lecithin and 69% of glycerin.
5. A process for preparing a cosmetic preparation for use in repairing skin barriers according to any one of claims 1 to 4, comprising the steps of:
1) sequentially adding water, glycerol, butanediol, EDTA disodium, xanthan gum, erythritol, sodium hyaluronate with the weight average molecular weight of 100-130 ten thousand daltons, sodium hyaluronate with the weight average molecular weight of 180-200 ten thousand daltons, sodium hyaluronate with the weight average molecular weight of 5000-10000 daltons, betaine and nicotinamide into a water phase pot according to the amount; stirring and heating to 80-90 ℃, homogenizing for 2-3 minutes until the mixture is completely dissolved, and obtaining a first solution;
2) sequentially adding a mixture of C14-22 alcohol, C12-20 alkyl glucoside, a mixture of glyceryl stearate and PEG-100 stearate, shea butter, cetostearyl alcohol, ethylhexyl palmitate, meadowfoam seed oil, phytosphingosine, ceramide 3, a mixture of hydrogenated lecithin, polydimethylsiloxane, hydrogenated polydecene, isononyl isononanoate, dioctyl carbonate, 1, 2-hexanediol and p-hydroxyacetophenone into an oil phase pot according to the amount, and stirring until the mixture is completely dissolved to obtain a second solution;
3) mixing water and arginine together according to a certain amount to obtain an arginine water solution, and heating the arginine water solution to 65-70 ℃ to completely dissolve the arginine water solution until the arginine water solution is transparent;
4) heating an emulsifying pot to 50-60 ℃, and then sequentially adding a first solution and a second solution under a vacuum condition;
5) heating an emulsifying pot to 70-80 ℃, starting stirring, homogenizing for 5-10 minutes, preserving heat for 20-30 minutes, sterilizing and cooling;
6) cooling the emulsifying pot to 50-60 ℃, and adding the heated arginine aqueous solution in the step 3);
7) continuously cooling the emulsifying pot to 40-50 ℃, and sequentially adding the saccharide isomerate, fibronectin, the Xinjiang carpet bugle extract and the essence according to the amount; stirring uniformly, and then inspecting;
8) discharging after the detection is qualified.
6. The method for preparing a cosmetic for repairing a skin barrier as claimed in claim 5, wherein the stirring speed in the step 1) is 30-40r/min, and the stirring speed in the homogenization is 2500-3000 r/min.
7. The method for preparing a cosmetic for repairing a skin barrier according to claim 5, wherein the stirring speed in the step 2) is 20 to 30 r/min.
8. The method for preparing a cosmetic for repairing a skin barrier as claimed in claim 5, wherein the stirring speed in the step 5) is 20-30r/min, and the stirring speed in the homogenization is 2500-3000 r/min.
9. The method for preparing a cosmetic for repairing a skin barrier according to claim 5, wherein the stirring speed in the step 7) is 15 to 20 r/min.
Technical Field
The invention relates to the technical field of cosmetics, in particular to a cosmetic for repairing a skin barrier and a preparation method thereof.
Background
The sebum membrane is the outermost layer of the skin, protecting the body from the environment. The sebaceous membrane is a protective membrane formed on the skin surface by emulsifying the grease secreted from sebaceous glands, the lipid produced by keratinocytes, the sweat secreted from sweat glands and the exfoliated keratinocytes at low temperature. The skin lipid film is the most important layer for water locking of the skin, can effectively lock water, prevent the excessive evaporation of the skin water and prevent the external water and certain substances from penetrating in a large amount, and as a result, the water content of the skin is kept in a normal state. The skin lipid membrane is an immune layer on the surface of the skin, and free fatty acids in the skin lipid membrane can inhibit the growth of certain pathogenic microorganisms and have a self-purification effect on the skin.
When the skin cell structure has problems, the oil secretion is abnormal or the keratinocyte differentiation has problems; physiological functions are affected by aging, skin damage or lesions cause problems in the formation of sebum membranes, which damage the natural barrier of the skin, resulting in excessive rapid loss of water from the skin and the easy entry of external irritants.
How to solve the problem that the skin barrier is damaged and the natural barrier of the damaged skin recovers the functions of moisture preservation, protection and exchange becomes the problem to be solved.
Disclosure of Invention
The invention aims to provide a cosmetic for repairing skin barrier and a preparation method thereof.
The invention adopts the following technical scheme:
a cosmetic for repairing skin barrier comprises the following components in parts by mass:
46.988-70.313 parts of water, 5.600-10.000 parts of glycerol, 2.100-3.750 parts of butanediol, 0.021-0.038 part of EDTA disodium, 0.070-0.125 part of xanthan gum, 0.350-0.625 part of erythritol, 0.021-0.038 part of sodium hyaluronate with the weight average molecular weight of 100-130 ten thousand daltons, 0.021-0.038 part of sodium hyaluronate with the weight average molecular weight of 180-200 ten thousand daltons, 0.035-0.063 part of sodium hyaluronate with the weight average molecular weight of 5000-10000 daltons, 0.350-0.625 part of betaine and 0.700-1.250 parts of nicotinamide;
0.700-1.250 parts of a mixture of C14-22 alcohol and C12-20 alkyl glucoside, 0.350-0.625 part of a mixture of glyceryl stearate and PEG-100 stearate, 0.700-1.250 parts of shea butter, 0.280-0.500 part of cetostearyl alcohol, 1.400-2.500 parts of ethylhexyl palmitate, 2.800-5.000 parts of a mixture of white meadowfoam seed oil, phytosphingosine, ceramide 3 and hydrogenated lecithin, 0.700-1.250 parts of polydimethylsiloxane, 2.100-3.750 parts of hydrogenated polydecene and 2.100-3.750 parts of isononyl isononanoate;
1.400-2.500 parts of dioctyl carbonate, 0.350-0.625 part of 1, 2-hexanediol and 0.350-0.625 part of p-hydroxyacetophenone;
1.400-2.500 parts of water and 0.070-0.125 part of arginine;
0.105-0.188 parts of saccharide isomerate, 2.100-3.750 parts of fibronectin, 3.500-6.250 parts of Xinjiang carpet bugle extract and 0.014-0.025 parts of essence;
wherein the weight average molecular weight of fibronectin is 40-80 KDA.
In the mixture of the C14-22 alcohol and the C12-20 alkyl glucoside, the content of the C14-22 alcohol is 25 percent and the content of the C12-20 alkyl glucoside is 75 percent in terms of the total mass percent of the mixture of the C14-22 alcohol and the C12-20 alkyl glucoside.
In the mixture of the glyceryl stearate and the PEG-100 stearate, the content of the glyceryl stearate is 50 percent and the content of the PEG-100 stearate is 50 percent according to the total mass percentage of the mixture of the glyceryl stearate and the PEG-100 stearate.
In the mixture of the meadowfoam seed oil, the phytosphingosine, the ceramide 3 and the hydrogenated lecithin, the content of the meadowfoam seed oil is 20 percent, the content of the phytosphingosine is 4 percent, the content of the ceramide 3 is 5 percent, the content of the hydrogenated lecithin is 2 percent and the content of the glycerol is 69 percent according to the total mass percentage of the mixture of the meadowfoam seed oil, the phytosphingosine, the ceramide 3 and the hydrogenated lecithin.
A method for preparing the cosmetic for repairing skin barrier comprises the following steps:
1) sequentially adding water, glycerol, butanediol, EDTA disodium, xanthan gum, erythritol, sodium hyaluronate with the weight average molecular weight of 100-130 ten thousand daltons, sodium hyaluronate with the weight average molecular weight of 180-200 ten thousand daltons, sodium hyaluronate with the weight average molecular weight of 5000-10000 daltons, betaine and nicotinamide into a water phase pot according to the amount; stirring and heating to 80-90 ℃, homogenizing for 2-3 minutes until the mixture is completely dissolved, and obtaining a first solution;
2) sequentially adding a mixture of C14-22 alcohol, C12-20 alkyl glucoside, a mixture of glyceryl stearate and PEG-100 stearate, shea butter, cetostearyl alcohol, ethylhexyl palmitate, meadowfoam seed oil, phytosphingosine, ceramide 3, a mixture of hydrogenated lecithin, polydimethylsiloxane, hydrogenated polydecene, isononyl isononanoate, dioctyl carbonate, 1, 2-hexanediol and p-hydroxyacetophenone into an oil phase pot according to the amount, and stirring until the mixture is completely dissolved to obtain a second solution;
3) mixing water and arginine together according to a certain amount to obtain an arginine water solution, and heating the arginine water solution to 65-70 ℃ to completely dissolve the arginine water solution until the arginine water solution is transparent;
4) heating an emulsifying pot to 50-60 ℃, and then sequentially adding a first solution and a second solution under a vacuum condition;
5) heating an emulsifying pot to 70-80 ℃, starting stirring, homogenizing for 5-10 minutes, preserving heat for 20-30 minutes, sterilizing and cooling;
6) cooling the emulsifying pot to 50-60 ℃, and adding the heated arginine aqueous solution in the step 3);
7) continuously cooling the emulsifying pot to 40-50 ℃, and sequentially adding the saccharide isomerate, fibronectin, the Xinjiang carpet bugle extract and the essence according to the amount; stirring uniformly, and then inspecting;
8) discharging after the detection is qualified.
In the step 1), the stirring speed is 30-40r/min, and the stirring speed during homogenizing is 2500-3000 r/min.
In the step 2), the stirring speed is 20-30 r/min.
In the step 5), the stirring speed is 20-30r/min, and the stirring speed during homogenizing is 2500-3000 r/min.
In the step 7), the stirring speed is 15-20 r/min.
The invention has the beneficial effects that:
the invention uses 40-80KDA small molecule fibronectin to cooperate with ceramide 3, the small molecule fibronectin has good permeability and is easy to be absorbed by skin cells, the fibronectin can delete different structural units with cell tissues, the core function of the skin cell tissues is kept, the small molecule fibronectin which is the same as the human skin cells is obtained, the fiber covering is formed by coagulation, the degradation of intercellular matrix ECM is promoted to release anchor cells, simultaneously, the cell factors are released to induce the cells to secrete new ECM, the skin cell structure is adjusted, the intercellular substance is better filled through the cooperation of the ceramide 3, the cells are amplified and differentiated, the cells are reconstructed, the skin metabolism function is improved, the formation of the natural barrier (sebaceous membrane) of the human body is promoted, the damaged skin barrier is repaired, and simultaneously, in order to accelerate the formation of the sebaceous membrane of the human body, the cholesterol with the same components of the sebaceous membrane is, the moisturizing effect and the exchange effect of the sebum of the human body on the skin are simulated, and an additional layer of protective film is endowed.
Drawings
Fig. 1 is a schematic view of a red-out effect before using the cosmetic for repairing skin barrier according to example 2 of the present invention.
Fig. 2 is a graph illustrating the de-reddening effect just after using the cosmetic for skin barrier repair of example 2 of the present invention.
Fig. 3 is a graph showing the red-out effect at one week using the cosmetic for repairing skin barrier according to example 2 of the present invention.
Fig. 4 is a graph showing the de-reddening effect before the cosmetic for repairing skin barrier according to example 1 of the present invention is used.
Fig. 5 is a graph illustrating the de-reddening effect just after using the cosmetic for skin barrier repair of example 1 of the present invention.
Fig. 6 is a graph showing the red-out effect at one week time using the cosmetic for repairing skin barrier according to example 1 of the present invention.
Fig. 7 is a graph showing the de-reddening effect before using the cosmetic for repairing skin barrier according to example 3 of the present invention.
Fig. 8 is a graph illustrating the de-reddening effect just after using the cosmetic for repairing skin barrier according to example 3 of the present invention.
Fig. 9 is a graph showing the red-out effect at one week time when the cosmetic for repairing skin barrier according to example 3 of the present invention was used.
Detailed Description
The following examples are given to illustrate the present invention and it is necessary to point out here that the following examples are given only for the purpose of further illustration of the invention and are not to be construed as limiting the scope of the invention.
The invention provides a cosmetic for repairing skin barriers, which comprises the components in parts by mass as shown in table 1. Wherein the weight average molecular weight of fibronectin is 40-80 KDA; the arginine water solution comprises the following components in parts by mass: 1.400-2.500 parts of water and 0.070-0.125 part of arginine.
Table 1 examples of cosmetic products for repairing the skin barrier provided by the invention
In the invention, the molecular weight of the sodium hyaluronate is weight average molecular weight, and can be obtained by adopting a gel chromatograph test.
In some embodiments, the mixture of C14-22 alcohol and C12-20 alkyl glucoside has a C14-22 alcohol content and a C12-20 alkyl glucoside content of 75% by weight of the total mixture of C14-22 alcohol and C12-20 alkyl glucoside.
In some embodiments, the mixture of glyceryl stearate and PEG-100 stearate contains 50% of glyceryl stearate and 50% of PEG-100 stearate, based on the total weight percentage of the mixture of glyceryl stearate and PEG-100 stearate.
In some embodiments, the mixture of meadowfoam seed oil, phytosphingosine, ceramide 3, and hydrogenated lecithin contains, as a percentage by mass of the total mixture of meadowfoam seed oil, phytosphingosine, ceramide 3, and hydrogenated lecithin, 20% of meadowfoam seed oil, 4% of phytosphingosine, 5% of ceramide 3, 2% of hydrogenated lecithin, and 69% of glycerol.
The method for preparing cosmetics for repairing skin barrier of examples 1 to 3, comprising the steps of:
1) sequentially adding water, glycerol, butanediol, EDTA disodium, xanthan gum, erythritol, sodium hyaluronate with the weight average molecular weight of 100-130 ten thousand daltons, sodium hyaluronate with the weight average molecular weight of 180-200 ten thousand daltons, sodium hyaluronate with the weight average molecular weight of 5000-10000 daltons, betaine and nicotinamide into a water phase pot according to the amount; stirring and heating to 80-90 ℃, homogenizing for 2-3 minutes until the mixture is completely dissolved, and obtaining a first solution;
2) sequentially adding a mixture of C14-22 alcohol, C12-20 alkyl glucoside, a mixture of glyceryl stearate and PEG-100 stearate, shea butter, cetostearyl alcohol, ethylhexyl palmitate, meadowfoam seed oil, phytosphingosine, ceramide 3, a mixture of hydrogenated lecithin, polydimethylsiloxane, hydrogenated polydecene, isononyl isononanoate, dioctyl carbonate, 1, 2-hexanediol and p-hydroxyacetophenone into an oil phase pot according to the amount, and stirring until the mixture is completely dissolved to obtain a second solution;
3) mixing water and arginine together according to a certain amount to obtain an arginine water solution, and heating the arginine water solution to 65-70 ℃ to completely dissolve the arginine water solution until the arginine water solution is transparent;
4) heating an emulsifying pot to 50-60 ℃, and then sequentially adding a first solution and a second solution under a vacuum condition;
5) heating an emulsifying pot to 70-80 ℃, starting stirring, homogenizing for 5-10 minutes, preserving heat for 20-30 minutes, sterilizing and cooling;
6) cooling the emulsifying pot to 50-60 ℃, and adding the heated arginine aqueous solution in the step 3);
7) continuously cooling the emulsifying pot to 40-50 ℃, and sequentially adding the saccharide isomerate, fibronectin, the Xinjiang carpet bugle extract and the essence according to the amount; stirring uniformly, and then inspecting;
8) discharging after the detection is qualified.
In some embodiments, the stirring speed in step 1) is 30-40r/min, and the stirring speed during homogenization is 2500-3000 r/min.
In some embodiments, the speed of stirring in step 2) is 20 to 30 r/min.
In some embodiments, in step 5), the stirring speed is 20-30r/min, and the stirring speed during homogenization is 2500-3000 r/min.
In some embodiments, the stirring speed in step 7) is 15-20 r/min.
The cosmetic of the comparative example provided by the present invention comprises the components in parts by mass as shown in table 2.
Table 2 cosmetic of comparative examples provided by the invention
Component name
Comparative example 1
Comparative example 2
Comparative example 3
Water (W)
78.769
69.670
62.088
Glycerol
5.600
8.000
10.000
Butanediol
2.100
3.000
3.750
EDTA disodium salt
0.021
0.030
0.038
Chinese gum
0.070
0.100
0.125
Erythritol and its preparation method
0.350
0.500
0.625
Sodium hyaluronate (130 ten thousand daltons)
0.021
0.030
0.038
Betaine
0.350
0.500
0.625
Nicotinamide
0.700
1.000
1.250
C14-22 alcohol, C12-20 alkyl glucoside
0.700
1.000
1.250
Glyceryl stearate, PEG-100 stearate
0.350
0.500
0.625
Butyrospermum PARKII (Butyrupium PARKII) pomace oil
0.700
1.000
1.250
Cetostearyl alcohol
0.280
0.400
0.500
Ethyl hexyl palmitate
1.400
2.000
2.500
Polydimethylsiloxane
0.700
1.000
1.250
Hydrogenated polydecene
2.100
3.000
3.750
Isononyl isononanoate
2.100
3.000
3.750
Carbonic acid dioctyl ester
1.400
2.000
2.500
1, 2-hexanediol
0.350
0.500
0.625
P-hydroxyacetophenone
0.350
0.500
0.625
Water (W)
1.400
2.000
2.500
Arginine
0.070
0.100
0.125
Saccharide isomerate
0.105
0.150
0.188
Essence
0.014
0.020
0.025
To better demonstrate the effect of the cosmetic for repairing skin barrier of the present invention, it was divided into two parts, first by a skin moisturizing type test, giving the effect of stimulating intercellular substance by giving a reddish effect, and then, giving a test of the cosmetic for repairing skin barrier of the present invention.
Testing the tool: the german CK company multi-probe skin test system MPA 10.
Testing a probe: corneometer CM825 (moisture test probe).
The test principle is as follows: the measurement of skin moisture is based on the internationally recognized Corneometer method, the capacitance method. The test is based on the completely different dielectric constants of water (81) and other substances (< 7). The change in capacitance exhibited by the capacitor was measured based on the moisture content of the sample. A glass plate separates the metal track (gold) at the top of the probe from the skin to prevent conduction of current in the sample. An electromagnetic field is gradually generated which is mutually attracted between the tracks. One orbital establishes an electron excess (-) and the other lacks electrons (+). During the measurement, the scattered field penetrates the first layer of the skin and determines the capacitance. Unlike impedance measurements, there is no galvanic relationship or polarization effect between the device and the measurement object.
Interpretation of the measurement results:
the following values are very effective on healthy skin and normal room conditions (20 ℃ and 40-60% air humidity).
TABLE 3 Germany CK company MPA10 test reference comparison table for multi-probe skin test system
Inner side of forearm
Is very dry
<30
Dry matter
30-40
Extremely moist
>40
In table 3, it is noted that the explanations for the moisture values "very dry", "dry" and "extremely moist" are chosen according to the manufacturer's experience, but only in a rough range, which values differ from the above-mentioned ranges due to environmental influences (temperature, relative humidity, geographical location and season). The values in table 3 are percentages, e.g., "< 30" means "< 30%", and so on.
Skin moisture test of trial subjects after using the cosmetics of example 2 and comparative example 2: and selecting 20 volunteers as trial objects, wherein the skin of the test subjects is healthy and meets the enrollment standard. The first 10 subjects applied the cosmetic of example 2 uniformly to the inner side of the forearm, the second 10 subjects applied the cosmetic of comparative example 2 uniformly to the inner side of the forearm, and the moisture content of the skin before application of the cosmetic, 10min, 30min, 1h, 1.5h and 2h was measured using the multi-probe skin test system MPA10 and the moisture test probe Corneometer CM825 of the german CK company, respectively, and repeated 3 times to obtain average values, and the average value of the moisture content of the skin was calculated. During the experiment, the subject was not able to apply any other cosmetic product at the experimental site. The specific test results are shown in table 4.
Table 4 skin moisture content test results of trial subjects after using the cosmetics of example 2 and comparative example 2
Skin moisture test of trial subjects after using the cosmetics of example 1 and comparative example 1: and selecting 20 volunteers as trial objects, wherein the skin of the test subjects is healthy and meets the enrollment standard. The first 10 subjects applied the cosmetic of example 1 uniformly to the inner side of the forearm, the second 10 subjects applied the cosmetic of comparative example 1 uniformly to the inner side of the forearm, and the moisture content of the skin before application of the cosmetic, 10min, 30min, 1h, 1.5h and 2h was measured using the multi-probe skin test system MPA10 and the moisture test probe Corneometer CM825 of the german CK company, respectively, and repeated 3 times to obtain average values, and the average value of the moisture content of the skin was calculated. During the experiment, the subject was not able to apply any other cosmetic product at the experimental site. The specific test results are shown in table 5.
Table 5 skin moisture content test results of trial subjects after using the cosmetics of example 1 and comparative example 1
Skin moisture test of trial subjects after using the cosmetics of example 3 and comparative example 3: and selecting 20 volunteers as trial objects, wherein the skin of the test subjects is healthy and meets the enrollment standard. The first 10 subjects applied the cosmetic of example 3 uniformly to the inner side of the forearm, the second 10 subjects applied the cosmetic of comparative example 3 uniformly to the inner side of the forearm, and the moisture content of the skin before application of the cosmetic, 10min, 30min, 1h, 1.5h and 2h was measured using the multi-probe skin test system MPA10 and the moisture test probe Corneometer CM825 of the german CK company, respectively, and repeated 3 times to obtain average values, and the average value of the moisture content of the skin was calculated. During the experiment, the subject was not able to apply any other cosmetic product at the experimental site. The specific test results are shown in table 6.
Table 6 skin moisture content test results of trial subjects after using the cosmetics of example 3 and comparative example 3
The values in tables 4, 5 and 6 are percentages, for example, "35.05" means "35.05%", and so on.
As can be seen from table 4, the results of the experiment comparing the values of example 2 and comparative example 2 show that: when the cosmetic of the comparative example is used for 10min, the average value of the skin moisture content is about 45%; when the cosmetic of the comparative example is used for 30min, the average value of the skin moisture content is about 40%, and when the cosmetic of the comparative example is used for 2H, the average value of the skin moisture content is almost equivalent to that before the use, which indicates that the moisturizing and water locking effects of the cosmetic of the comparative example are poor; when the cosmetic for repairing the skin barrier is used for 10min, the average value of the skin moisture content is 53.53-67.69%, which is obviously higher than 40%, and then the average value of the skin moisture content of the trial objects is gradually reduced until the average value of the skin moisture content of the trial objects is more than 40% when the cosmetic for repairing the skin barrier is used for 2h, which shows that the cosmetic for repairing the skin barrier has better moisturizing effect on the skin and can achieve the long-acting water-locking and moisturizing effect.
As can be seen from tables 5 and 6, the skin moisture content test results of the cosmetics of examples 1 and 3 are similar to those of example 2, and the obtained results also demonstrate that the water-retaining moisturizing cosmetic of the present invention can replenish and lock the moisture in the skin more effectively, and will not be described again here.
As can be seen from tables 4, 5, and 6, the effect of supplementing and locking the moisture in the skin of the cosmetic of example 2 is superior to the effect of supplementing and locking the moisture in the skin of the cosmetic of examples 1 and 3, and the effect of supplementing and locking the moisture in the skin of the cosmetic of example 3 is slightly inferior to the effect of supplementing and locking the moisture in the skin of the cosmetic of example 1.
In order to better demonstrate the effect of the cosmetic for repairing skin barrier of the present invention, the effect of biomimetic intercellular substance was given by the red-removing effect, and the test of the cosmetic for repairing skin barrier of the present invention was given later.
Testing the tool: VISIA-CR, Canfield, USA
Whether the sebaceous membrane is repaired is judged through the red removing effect, and the red blood streak is mainly caused by the fact that the position of a capillary vessel is easy to contact and sense the change of an external environment due to the fact that the stratum corneum of the face is weak, so that the phenomenon of the face caused by the expansion of the capillary vessel is caused. Red blood filaments are mainly manifested by telangiectasia of skin, which is caused by low skin immunity. The common formation reason of the red blood filaments is that cutin is damaged, and capillary vessels lose the natural protection of the cutin layer, so that the red blood filaments are stimulated by the external environment for a long time to cause the blood vessels to expand, block and damage; the congenital capillary blood vessel on the face is shallow, so that the face phenomenon is caused, the skin is thin and sensitive, and the face is redder when the face is too cold, too hot and emotional agitation occurs, so that the red blood streak phenomenon is formed.
As can be seen from fig. 1-3: before the cosmetic for repairing skin barrier of embodiment 2 of the present invention is used, the left front cheek of the user has a large area of red color blocks; immediately after using the cosmetic for repairing skin barrier of example 2 of the present invention, the user's left front cheek red patches were significantly reduced; when the cosmetic for repairing skin barrier of example 2 of the present invention was used for one week, the user's facial red patches were significantly reduced. This indicates that the cosmetic for repairing skin barrier according to example 2 of the present invention has a very good red-removing repair effect.
As can be seen from fig. 4-6: before using the cosmetic for repairing skin barrier of example 1 of the present invention, the user's left and right anterior buccal pouch large area red blood streak; immediately after using the cosmetic for repairing skin barrier according to example 1 of the present invention, the red blood filaments at the pouch region of the user were significantly reduced; when the cosmetic for repairing skin barrier of example 1 of the present invention was used for one week, the red blood filaments of the user's pouch region were changed to some extent. This shows that the cosmetic for repairing skin barrier of example 1 of the present invention has a very good red-removing repair effect, but the red-removing repair effect is slightly slower than that of example 2.
As can be seen from fig. 7-9: before using the cosmetic for repairing skin barrier according to example 1 of the present invention, the forehead and the left and right front cheeks of the user had mild red blood streaks; immediately after using the cosmetic for repairing skin barrier according to example 1 of the present invention, the forehead and left and right front cheeks of the user did not have an obvious red removal repairing effect; when the cosmetic for repairing skin barrier of example 1 of the present invention was used for one week, the forehead and the left and right front cheeks of the user had a slight red-removing repairing effect. This shows that the cosmetic for repairing skin barrier of example 1 of the present invention has a good red-removing repair effect, but the red-removing repair effect is not significant compared to example 2.
In conclusion, the cosmetic for repairing skin barrier of example 2 has a remarkable red-removing and repairing effect, and has a good skin barrier improving and repairing effect when continuously used.
It should be noted that the various features described in the foregoing embodiments may be combined in any suitable manner without departing from the scope of the invention. The invention is not described in any further detail in order to avoid unnecessary repetition.
The present invention has been described in detail with reference to the embodiments, which are illustrative rather than restrictive, and variations and modifications thereof are possible within the scope of the present invention without departing from the general inventive concept.