阅读说明：本技术 使用rf的皮肤治疗设备 (Skin treatment device using RF ) 是由 姜栋丸 沈旼廷 金熹永 金亨门 于 2019-10-07 设计创作，主要内容包括：本发明提供一种使用RF的皮肤治疗设备,包括：用于产生RF输出的RF发生器、包括施予器主体及设置于所述施予器主体的前面以插入至治疗对象的皮肤真皮层,并电连接于所述RF发生器以传递所述RF输出的多个针的双极型施予器,当所述施予器开启(on)时,所述施予器向所述治疗对象传递对应所述RF输出的单个或多个RF脉冲,其中所述RF输出为5W以上且13W以下,所述RF输出的频率大于1MHz且小于3MHz,由所述RF输出产生的所述RF脉冲的持续时间为50ms以上且100ms以下。(The present invention provides a skin treatment device using RF, including: an RF generator for generating an RF output, a bipolar applicator including an applicator body and a plurality of needles disposed in front of the applicator body for insertion into the dermal layer of the skin of a subject and electrically connected to the RF generator for delivering the RF output, the applicator delivering a single or a plurality of RF pulses corresponding to the RF output to the subject when the applicator is turned on (on), wherein the RF output is 5W or more and 13W or less, the frequency of the RF output is greater than 1MHz and less than 3MHz, and the duration of the RF pulses generated by the RF output is 50ms or more and 100ms or less.)

1. A skin treatment device using RF, comprising:

an RF generator for generating an RF output;

a bipolar applicator including an applicator body and a plurality of needles disposed in front of the applicator body for insertion into a dermal layer of a subject's skin and electrically connected to the RF generator for delivering the RF output,

when the applicator is turned on (on), the applicator delivers to the subject a single or multiple RF pulses corresponding to the RF output,

to reduce the pigmentation of the skin caused by the RF output,

the frequency of the RF output is greater than 1MHz and less than 3MHz,

the RF output is 5W or more to increase the reduction amount of melamine and 13W or less to prevent the decrease in the survival rate of melamine cells,

the RF output generates the RF pulses with a duration of 50ms or more to increase the reduction of melamine and 100ms or less to prevent the decrease of the survival rate of melamine cells.

2. The skin treatment device of claim 1,

the number of the needles is more than 16 and less than 49,

the depth of the needle penetrating into the skin is more than 0mm and less than 1 mm.

3. The skin treatment device using RF according to claim 1,

the RF output frequency is 2 MHz.

4. A skin treatment device using RF, comprising:

an RF generator for generating an RF output;

a bipolar applicator including an applicator body and a plurality of needles disposed in front of the applicator body for insertion into a dermal layer of a subject's skin and electrically connected to the RF generator for delivering the RF output,

when the applicator is turned on (on), the applicator delivers to the subject a single or multiple RF pulses corresponding to the RF output,

the RF output is 5W or more and 13W or less,

the frequency of the RF output is greater than 1MHz and less than 3MHz,

the RF pulse generated by the RF output has a duration of 50ms or more and 100ms or less.

5. The use skin treatment device of claim 4,

the number of the needles is more than 16 and less than 49,

the depth of the needle penetrating into the skin is more than 0mm and less than 1 mm.

6. The skin treatment device using RF according to claim 4,

the RF output frequency is 2 MHz.

Technical Field

The present invention relates to a skin treatment apparatus using RF that can effectively treat skin pigmentation.

Background

Various methods have been used in order to improve Pigmentation (Pigmentation). Methods of using Energy based devices (Energy based devices) include Intense Pulsed Light (IPL) and lasers. The method for using the medicine comprises vitamin C, Tretinoin, hydroquinone, etc. In addition, Glycolic Acid Peeling (Glycolic Acid Peeling), TCA Peeling, Phenol Peeling (Phenol Peeling) have been used as chemical Peeling.

Among them, the most widely used is laser, and there are various kinds thereof, that is, Nd: YAG skin cleaning laser (laser), lattice laser (lattice laser), Dye/yellow laser (Dye/yellow laser), Long pulse (Long Pulsed) Nd: YAG. However, the use of laser light to treat pigmentation has the fatal disadvantage of causing many problems.

First, Post-Inflammatory Pigmentation (PIH) and Hyperpigmentation (Hyperpigmentation). When the skin is inflamed, excessive melanin is produced in order to protect the skin, resulting in brown or deep red pigmentation at the site of operation. This is caused by excessive laser energy, and is caused by excessive phagocytosis activity causing melanocytes (melanophores) to stay in the deep layer of the skin due to thermal damage (thermoaging) to the surrounding tissue and the deeper region of the skin layer where the colorimetric elements are located, since photon (photon) energy is 1 to 3 eV.

Second, Hypopigmentation (Hypopigmentation). Is a symptom that occurs when melanin at the site of operation is relatively deficient compared to the surrounding skin, and the site of operation becomes excessively white compared to the surrounding tissue. This occurs because the high energy of the laser causes destruction of melanocytes, which produce melanin pigment, during the transmission of excessive energy into the skin. This has fatal problems that it is difficult to recover, and it often occurs when the number of laser operations is large.

In addition, IPLs have a wide wavelength range and have a high total energy, but the specific energy Intensity (Intensity) required to treat black spots is relatively low, and thus black spot treatment is limited. In addition, there is a problem of damaging surrounding cells by applying a relatively large amount of energy.

Disclosure of Invention

Technical problem

An object of the present invention is to provide a skin treatment apparatus using RF that can effectively treat pigmentation of the skin.

Technical scheme

According to an aspect of the present invention, there is provided a skin treatment device using RF, including: an RF generator for generating an RF output, a bipolar applicator including an applicator body and a plurality of needles disposed in front of the applicator body for insertion into the dermal layer of the skin of a subject and electrically connected to the RF generator for delivering the RF output, the applicator delivering a single or a plurality of RF pulses corresponding to the RF output to the subject when the applicator is turned on (on), wherein the RF output is 5W or more and 13W or less, the frequency of the RF output is greater than 1MHz and less than 3MHz, and the duration of the RF pulses generated by the RF output is 50ms or more and 100ms or less.

In the present invention, the number of the needles may be 16 or more and 49 or less.

Also, in the present invention, the frequency of the RF output may be 2 MHz.

Technical effects

According to the skin treatment apparatus using RF of the present invention, the pigmentation of the skin is greatly reduced by using the RF output.

Drawings

Fig. 1 is a constitutional view of a skin treatment apparatus using RF according to an embodiment of the present invention;

FIG. 2 is one embodiment of the RF output delivered to the skin of the skin treatment device of FIG. 1 using RF;

fig. 3 to 4 are graphs of experimental results of cell viability (cell viability) using the skin treatment apparatus using RF of fig. 1;

FIG. 5 is a graph of experimental results for HRM2 cell death animals;

fig. 6 to 8 are graphs of experimental results for measuring the reduction in the amount of melamine using the skin treatment apparatus using RF of fig. 1;

fig. 9 is an experimental result photograph showing the result of UV irradiation every two days during 28 days after RF pulses of the skin treatment apparatus using RF of fig. 1 were applied to a pigmented mouse once;

fig. 10 is a result of observing the level of inhibition of proliferation of melanocytes by chemical staining called cell proliferation assay (PCNA) in a mouse animal experiment (HRM 2).

Detailed Description

Hereinafter, embodiments of the present invention will be described below with reference to the drawings.

Referring to fig. 1, a skin treatment device 100 using Radio Frequency (RF) according to one embodiment of the present invention is shown. The skin treatment device using RF 100 includes an RF generator 110 and an applicator 120. The RF generator 110 performs the function of generating an RF output. As the RF generator, various known devices that generate outputs required in the present embodiment can be applied.

The applicator 120 includes an applicator body 121 and a plurality of needles 125. The applicator 120 is formed to be able to be held by a user (doctor or the like), and includes various operation devices (not shown) such as an on/off switch (not shown), RF output settings, and the like. The applicator 120 is bipolar.

The needle 125 is disposed in front of the applicator body 121. The pin 125 is formed of a conductive material and is electrically connected to the RF generator 110 to deliver the RF output. The RF output is delivered to the skin of the subject as RF pulses having a variety of shapes, such as a rectangular shape.

The applicator 120 is inserted into the dermal layer of the skin of the subject prior to operation (on). For this purpose, the needle 125 is inserted approximately to a depth of 1mm or less (i.e., 0 < penetration depth. ltoreq.1 mm). However, the present invention is not limited thereto. In addition, the number of the needles 125 is 16 to 49, but the present invention is not limited thereto.

When the applicator 120 is on (on), the applicator 120 delivers a single or multiple RF pulses corresponding to the RF output to the subject, and then the applicator is automatically off (off). Fig. 2 shows an embodiment of the RF pulses.

Referring to fig. 2, when the applicator is operated once (one RF pulse or two RF pulses are generated and delivered to the skin of the subject between on and off, the duration of the RF pulses in the present invention is the duration of the pulses applied to the skin during one operation of the applicator (the duration of a single pulse in the case of a single pulse; the sum of the durations (first and second durations) in the case of a plurality of pulses)). however, the present invention is not limited thereto, and more than 3 RF pulses can be generated and delivered to the skin of the subject when the applicator is operated once.

In order to optimize the skin pigmentation effect of the treatment subject, the condition of the RF output of the skin treatment apparatus using RF was set by the following experiment and analysis.

Fig. 3 to 4 are graphs showing results of a Human primary melanocyte death experiment (HEMn) cell viability) experiment performed once using the skin treatment apparatus using RF.

In this experiment, the setting parameters of the RF output were RF output (watts, W), RF frequency (hertz, MHz) and duration of RF pulse. The subject of the experiment was 1X10^4 cells, and the experiment was performed in order to confirm the conditions for cell death. Here, HEMN Cell Viability (%) refers to Cell Viability.

In addition, in fig. 3 to 4, cell survival rates at 1MHz and 2MHz of RF output for a specific pulse duration are shown. The RF pulse is applied to the subject once a day, the RF output is performed in 1W units from 1W to 15W, and the duration of the RF pulse is 20ms, 50ms, 70ms, 100ms, 120ms, 150ms, 170ms, 200 ms. The number of needles is 16.

It can be seen from the experimental results that, regardless of the RF output, the survival rate of the cells is greatly reduced when the duration of the RF pulse is 120ms or more (see fig. 4). In addition, when the duration of the RF pulse is 50ms and 70ms and the RF output is 15W or more, the survival rate of the cells is greatly reduced, and when the duration of the RF pulse is 100ms and the RF output is 14W or more, the survival rate of the cells is greatly reduced (see fig. 3).

From the experimental results, it is found that in the range where the frequency of the RF output is more than 1MHz and less than 3MHz, the duration of the RF pulse is preferably 100ms or less, and the RF output is selected to be 13W or less.

Fig. 5 shows the results of the HRM2 cell death animal experiment, and it can be seen that when the duration of the RF pulse is 150ms or more or the RF output is 15W or more, the cell death rate is significantly increased (excluding the case where the RF duration is 20ms and the RF output is 15W).

Referring to fig. 6 to 8, the experiment for measuring the decrease in the amount of melamine is a Melanin amount measurement (Melanin assay) experiment. As for HEMN, the experimental subjects were 1x10^4 cells. Here, the melamine amount ratio (malamin amount ratio) refers to a ratio of the melamine amount.

Fig. 6 to 8 are results of applying RF pulses to the subject once a day. The RF output is performed in 1W units from 1W to 15W, and the duration of the RF pulse is 20ms, 50ms, 70ms, 100ms, 120ms, 150ms, 170ms, 200 ms. The number of needles is 16.

From the experimental results, it was confirmed that the amount of melamine was significantly reduced when the RF output was 5W or more and the duration of RF was 50ms or more, and the RF frequency was more than 1 MHz.

In this way, it was found that skin pigmentation can be effectively treated by a single melamine apoptosis test and a melamine amount reduction test in a human body, wherein the RF output is 5W to 13W, the frequency of the RF output is more than 1MHz to less than 3MHz, and the duration of the RF pulse output by the RF output is 50ms to 100 ms.

Fig. 9 is an experimental result photograph showing the results of UV irradiation every two days during 28 days after RF pulse was applied to the pigmented mice. In fig. 9, the second photograph from the left shows a state where UV is irradiated without applying RF, and the third and fourth photographs show states where RF of 10W is applied for 50ms and 100ms, respectively. The experimental results show a state where melamine is greatly reduced when RF is applied, and the reduction is greater at 100 ms.

Fig. 10 is a result of observing the level of inhibition of proliferation of melanocytes by chemical staining called cell proliferation assay (PCNA) in a mouse animal experiment (HRM 2).

Referring to the tissue photograph of fig. 10 (a), it can be seen that the tissue corresponding to the RF output of 5W or more and less than 15W, RF pulse duration of 50ms to 100ms has a lighter brown color at the intersection of the skin surface and the melanocyte than the comparative example, as compared with the uppermost tissue photograph on the right (comparative example). This means that the proliferation of melanocytes is inhibited. As long as the tissue is under at least one condition of the RF output of 15W or the RF duration of 150ms, the cell proliferation is suppressed to such an extent that the tissue hardly turns brown, but falls within a range where cell death occurs, and thus is not considered to be effective.

Fig. 10 (B) is data quantifying the result of fig. 10 (a). The black bar labeled "0" on the horizontal axis represents the same group as UVB tissue pictures of PCNA tissue. As described above, it was shown that cell proliferation was inhibited when the RF output was 5W or more and less than 15W and the RF pulse duration was 50-100ms, compared to the black bar graph. However, as long as cell proliferation is further inhibited in a group belonging to at least one condition of RF output 15W or RF duration 150ms, this is not considered to be effective since it is a condition under which cell death occurs.

The present invention has been described with reference to the embodiments shown in the drawings, which are intended to be illustrative only, and various modifications and equivalent other embodiments will be apparent to those of ordinary skill in the art. Therefore, the true technical scope of the present invention should be determined by the technical spirit of the scope of the appended claims.

Industrial availability

With the present invention, a skin treatment apparatus using RF capable of effectively treating pigmentation can be manufactured.