阅读说明：本技术 一种可护眼与提高记忆的蓝莓粉复方固体制剂及其制备方法和应用 (Blueberry powder compound solid preparation capable of protecting eyes and improving memory and preparation method and application thereof ) 是由 杨雪峰 于 2020-12-10 设计创作，主要内容包括：本发明公开一种可护眼与提高记忆的蓝莓粉复方固体制剂及其制备方法和应用,一种可护眼与提高记忆的蓝莓粉复方固体制剂,包括重量比例为10～90份的蓝莓粉、5～30份的叶黄素酯、10～70份的N-乙酰神经氨酸、10～90份的茶叶茶氨酸、0.1～5份的姜黄素以及10～60份的白果粉,一种可护眼与提高记忆的蓝莓粉复方固体制剂的制备方法包括a)混合、b)造粒、c)粉碎和d)后处理,本发明所制备的蓝莓粉复方固体制剂的所有成分均为普通食品、药食同源物品、新食品原料、新食品原料终止审查物品以及食品添加剂等法规允许食用的物品,同时适宜于青少年以及中老年人群,对于护眼及提高记忆力同时具有显著效果。(The invention discloses a blueberry powder compound solid preparation capable of protecting eyes and improving memory and a preparation method and application thereof, the blueberry powder compound solid preparation capable of protecting eyes and improving memory comprises 10-90 parts by weight of blueberry powder, 5-30 parts by weight of lutein ester, 10-70 parts by weight of N-acetylneuraminic acid, 10-90 parts by weight of tea theanine, 0.1-5 parts by weight of curcumin and 10-60 parts by weight of white fruit powder, and the preparation method of the blueberry powder compound solid preparation capable of protecting eyes and improving memory comprises a) mixing, b) granulating, c) crushing and d) post-treatment, all components of the blueberry powder compound solid preparation prepared by the invention are common food, medicinal and edible materials, new food raw material censorship stopping articles, food additives and other articles allowed to eat by laws and regulations, and are suitable for teenagers and middle-aged people, has obvious effects of protecting eyes and improving memory.)

1. A blueberry powder compound solid preparation capable of protecting eyes and improving memory is characterized in that: the blueberry and tea leaf tea beverage comprises, by weight, 10-90 parts of blueberry powder, 5-30 parts of lutein ester, 10-70 parts of N-acetylneuraminic acid, 10-90 parts of tea theanine, 0.1-5 parts of curcumin and 10-60 parts of white fruit powder.

2. The compound solid preparation of blueberry powder capable of protecting eyes and improving memory as claimed in claim 1, wherein: the blueberry and tea leaf tea beverage comprises, by weight, 40-90 parts of blueberry powder, 10-25 parts of lutein ester, 50-70 parts of N-acetylneuraminic acid, 40-80 parts of tea theanine, 0.25-5 parts of curcumin and 30-60 parts of white fruit powder.

3. The compound solid preparation of blueberry powder capable of protecting eyes and improving memory as claimed in claim 2, wherein: comprises 40 parts of blueberry powder, 15 parts of lutein ester, 50 parts of N-acetylneuraminic acid, 40 parts of tea theanine, 0.25 part of curcumin and 35 parts of ginkgo powder in parts by weight.

4. The compound solid preparation of blueberry powder capable of protecting eyes and improving memory as claimed in claim 2, wherein: comprises 80 parts of blueberry powder, 25 parts of lutein ester, 70 parts of N-acetylneuraminic acid, 70 parts of tea theanine, 2 parts of curcumin and 60 parts of white fruit powder.

5. The compound solid preparation of blueberry powder capable of protecting eyes and improving memory as claimed in claim 2, wherein: comprises 90 parts of blueberry powder, 15 parts of lutein ester, 50 parts of N-acetylneuraminic acid, 80 parts of tea theanine, 5 parts of curcumin and 30 parts of white fruit powder.

6. A preparation method of a blueberry powder compound solid preparation capable of protecting eyes and improving memory is characterized by comprising the following steps:

a) mixing: weighing 10-90 parts of blueberry powder, 5-30 parts of lutein ester, 10-70 parts of N-acetylneuraminic acid, 10-90 parts of theanine, 0.1-5 parts of curcumin and 10-60 parts of white fruit powder in parts by weight, and putting into a mixing container to be uniformly mixed to obtain mixed powder;

b) and (3) granulation: carrying out wet granulation or dry granulation and size stabilization on the mixed powder obtained in the step a) to obtain mixed particles;

c) crushing: drying, crushing and sieving the mixed particles obtained in the step b) at low temperature to obtain screened powder;

d) and (3) post-treatment: removing metal foreign matters in the screened powder obtained in the step c), carrying out metal detection inspection after internal packaging, then sterilizing, and carrying out external packaging to obtain a finished product.

7. The preparation method of the blueberry powder compound solid preparation capable of protecting eyes and improving memory as claimed in claim 6, wherein the preparation method comprises the following steps: in the step b), the number of the whole grains is 10-30 meshes.

8. The preparation method of the blueberry powder compound solid preparation capable of protecting eyes and improving memory as claimed in claim 6, wherein the preparation method comprises the following steps: in the step c), the screening mesh number is 80-120 meshes, and the drying temperature is lower than 50 ℃.

9. The preparation method of the blueberry powder compound solid preparation capable of protecting eyes and improving memory as claimed in claim 6, wherein the preparation method comprises the following steps: in the step d), the sterilization mode adopts ultrahigh pressure sterilization, pasteurization or irradiation sterilization.

10. The application of the blueberry powder compound solid preparation capable of protecting eyes and improving memory is characterized in that: the blueberry powder compound solid preparation capable of protecting eyes and improving memory as claimed in claim 1 is added into common food, health food or medicines as a main raw material or an auxiliary material.

[ technical field ] A method for producing a semiconductor device

The invention relates to the technical field of compound solid preparations, in particular to a blueberry powder compound solid preparation capable of protecting eyes and improving memory, and a preparation method and application thereof.

[ background of the invention ]

Asthenopia refers to eye fatigue caused by excessive use of eyes while working or learning at close distances. This condition is often prone to people engaged in close-range precision work or computer work, people who learn or work in environments with poor lighting conditions (over-bright/over-dark light), people with refractive errors such as myopia, hyperopia, and presbyopia, and people with physical weakness. The symptoms of asthenopia include blurred vision after a long time, inability to write or read, dry eyes, dizziness and pain, and nausea in severe cases. Excessive visual cell depletion can lead to increased metabolic waste, accumulation of oxygen radicals, and inadequate supply of ocular nutrients, thus exacerbating asthenopia symptoms.

Visual fatigue is too severe and memory loss occurs. Memory impairment is a common symptom in the elderly, and if there is a lack of effective prevention and treatment, a significant portion of them will develop senile dementia. Through certain intervention means, such as health education, memory training, nutritional health food supplement and the like, the memory capacity of teenagers and middle-aged and elderly people can be improved, so that the learning achievement of the teenagers is improved, and the life quality of the elderly people is improved.

With the improvement of health consciousness of the national people in China, self-care mainly based on prevention, health care, healthy living style, healthy living environment and the like is taken as a core, and the idea of taking disease treatment as an auxiliary is continuously strengthened. The trend of nutrition and health care towards food is a future development trend, and the market demand is huge. The nutritional health-care safe food which is required by different people and is prepared by adopting common food, medicinal and edible food, new food raw materials, food additives and the like as raw and auxiliary materials has become necessary requirements of consumers.

Chinese patent publication No. CN108619399A discloses a compound preparation for protecting eyes and improving eyesight and a preparation method thereof, wherein the compound preparation is prepared by mixing glossy privet fruit, fennel fruit, ginger processed pinellia tuber, celandine, acanthopanax root, tall gastrodia tuber, Indian buead, dittany bark, pennycress, arisaema tuber, Chinese pine nodular branch, lutein and blueberry according to a certain proportion. The patent adopts a large amount of Chinese herbal medicine compound components, can not be eaten as common food, and has unclear toxic and side effects after long-term eating.

Chinese patent publication No. CN107410633A discloses a production technology of a tabletting hard candy with eye-protecting and brain-strengthening effects, which is prepared by mixing defatted perilla powder, inulin, xylitol, lutein and blueberry extract according to a certain proportion and tabletting. The patent is prepared from food raw and auxiliary materials, has a certain eye protection effect, but has a very slight brain strengthening effect, and can not give consideration to the eye protection and brain strengthening nutrition differentiation requirements of teenagers and old people.

Chinese patent with publication number CN106581204A discloses a Chinese herbal compound extract for assisting in improving memory, which is prepared by mixing maca, polygala root and spina date seed according to a certain proportion. The patent adopts special compound components for health-care food, can not be eaten as common food, and has no obvious effect on assisting in improving memory.

[ summary of the invention ]

The invention aims to solve the problems in the prior art, provides a blueberry powder compound solid preparation capable of protecting eyes and improving memory, and a preparation method and application thereof, is suitable for teenagers and middle-aged and elderly people, and has obvious effects of protecting eyes and improving memory.

In order to achieve the purpose, the invention is realized by the following technical scheme:

a blueberry powder compound solid preparation capable of protecting eyes and improving memory comprises, by weight, 10-90 parts of blueberry powder, 5-30 parts of lutein ester, 10-70 parts of N-acetylneuraminic acid, 10-90 parts of tea theanine, 0.1-5 parts of curcumin and 10-60 parts of white fruit powder.

Preferably, the blueberry powder comprises, by weight, 40-90 parts of blueberry powder, 10-25 parts of lutein ester, 50-70 parts of N-acetylneuraminic acid, 40-80 parts of theanine, 0.25-5 parts of curcumin and 30-60 parts of white fruit powder.

Preferably, the ginkgo biloba extract comprises 40 parts by weight of blueberry powder, 15 parts by weight of lutein ester, 50 parts by weight of N-acetylneuraminic acid, 40 parts by weight of tea theanine, 0.25 part by weight of curcumin and 35 parts by weight of ginkgo biloba powder.

Preferably, the blueberry powder comprises 80 parts by weight of blueberry powder, 25 parts by weight of lutein ester, 70 parts by weight of N-acetylneuraminic acid, 70 parts by weight of tea theanine, 2 parts by weight of curcumin and 60 parts by weight of white fruit powder.

Preferably, the blueberry powder comprises 90 parts by weight of blueberry powder, 15 parts by weight of lutein ester, 50 parts by weight of N-acetylneuraminic acid, 80 parts by weight of tea theanine, 5 parts by weight of curcumin and 30 parts by weight of white fruit powder.

A preparation method of a blueberry powder compound solid preparation capable of protecting eyes and improving memory comprises the following steps:

a) mixing: weighing 10-90 parts of blueberry powder, 5-30 parts of lutein ester, 10-70 parts of N-acetylneuraminic acid, 10-90 parts of theanine, 0.1-5 parts of curcumin and 10-60 parts of white fruit powder in parts by weight, and putting into a mixing container to be uniformly mixed to obtain mixed powder;

b) and (3) granulation: carrying out wet granulation or dry granulation and size stabilization on the mixed powder obtained in the step a) to obtain mixed particles;

c) crushing: drying, crushing and sieving the mixed particles obtained in the step b) at low temperature to obtain screened powder;

d) and (3) post-treatment: removing metal foreign matters in the screened powder obtained in the step c), carrying out metal detection inspection after internal packaging, then sterilizing, and carrying out external packaging to obtain a finished product.

Preferably, in the step b), the number of the whole grains is 10 to 30.

Preferably, in the step c), the screening mesh number is 80-120 meshes, and the drying temperature is lower than 50 ℃.

Preferably, in the step d), the sterilization mode adopts ultra-high pressure sterilization, pasteurization or irradiation sterilization.

An application of a blueberry powder compound solid preparation capable of protecting eyes and improving memory is characterized in that the blueberry powder compound solid preparation capable of protecting eyes and improving memory is used as a main raw material or an auxiliary material and is added into common food, health food or medicines.

The general food, health food or medicine includes, but is not limited to, tablets, capsules, granules, oral liquid, hard candy, gel candy, solid beverage, liquid beverage, jelly, baked food, cake, etc.

The anthocyanin contained in the blueberry powder can effectively improve the activity of superoxide dismutase, glutathione peroxidase and the like of photodamaged retinal cells and the total protein content, and obviously reduce the content of malondialdehyde. In addition, by observation of histopathology, blueberry anthocyanin can protect cells of each layer of retina completely, improve damaged cells and increase the thickness of an outer nucleus layer of retina. Therefore, the blueberry anthocyanin has a remarkable protective effect on retinal photodamage.

Anthocyanin contained in the blueberry powder can obviously improve learning and memory disorder and influence NF-kB signal transduction pathway, thereby inhibiting oxidative stress and inflammatory reaction, reducing lipofuscin accumulation in brain tissue, improving antioxidant function and regulating and controlling the expression of cognition related protein in nervous system.

Researches show that blue light in nature and on a display screen is a main cause of damage to a macular area of a retina of a human eye. Blue light has higher energy and can induce the mass generation of reactive oxygen species, thereby directly damaging retinal nerve cells. The lutein ester is a main component forming the macular pigment of the human eye, mainly plays a role in filtering blue light, and simultaneously can quench singlet oxygen, control the generation of active oxygen clusters, and reduce the oxidation caused by illumination. The intake of the food rich in lutein ester can increase the content of lutein in tissues, and plays an important role in preventing and protecting age-related macular degeneration.

N-acetylneuraminic acid plays an important role in the growth and development of the nervous system and brain, is an important component of ganglioside, and is also involved in synaptic transmission. The exogenous supply of N-acetylneuraminic acid can increase the concentration of ganglioside in brain, and improve learning ability, especially cognitive level.

There is a correlation between the composition of N-acetylneuraminic acid in the brain and the growth of nerve cells and the extension of processes. In the blood or brain of some patients with neurological diseases such as senile dementia, incipient wetness and schizophrenia, the content of N-acetylneuraminic acid is obviously reduced, but the content is gradually normal along with the development of rehabilitation therapy. The N-acetylneuraminic acid ganglioside has obvious effects on treating cerebral ischemia, Parkinson's disease, senile dementia and nerve trauma.

Theanine can pass through brain barrier and has certain protection effect on neuronal damage caused by transient ischemia of brain. The structural similarity of theanine, which is a neurotransmitter related to memory, determines its specific role in the nervous system. Theanine can strongly act on glutamine transporters, thereby inhibiting the concerted transport of glutamine outside cells to neurons, and finally inhibiting the conversion of glutamine into glutamic acid.

Theanine not only reverses cognitive impairment due to chronic stress, alleviates oxidative damage due to chronic stress, but also restores abnormal levels of corticosterone and catecholamine in the plasma and brain. Therefore, theanine also has a good protective effect on cognitive impairment caused by chronic restraint stress.

The sleep has the functions of promoting growth and development, maintaining individual survival, forming memory and the like. Sleep deprivation refers to a series of changes in learning, memory, mood, and immune functions caused by failure to satisfy normal sleep due to its own or environmental causes, accompanied by changes in mind, physiology, and even behavior caused by increased fatigue. Curcumin can protect the sleep-deprived cardiac muscle tissue by improving the oxidation resistance of the cardiac muscle tissue, reducing the level of inflammatory factors, relieving oxidative stress injury and other mechanisms, and plays a role in inhibiting inflammatory reaction through a TLR 4/NF-KB signal channel, thereby effectively improving the cognitive function of sleep deprivation.

The bilobalide can promote neuron autophagy, inhibit neuron apoptosis, relieve acute phase tissue lesion and nerve dysfunction caused by ischemic brain injury, improve ischemic brain injury, convalescent phase nerve motor function, promote convalescent phase tissue repair, and promote proliferation and differentiation of neural stem cells, thereby promoting recovery phase function improvement of ischemic brain injury and endogenous nerve regeneration level.

The invention has the beneficial effects that:

1) all components of the blueberry powder compound solid preparation prepared by the invention are common food, medicinal and edible substances, new food raw materials, new food raw material censorship stopping substances, food additives and other substances which are allowed to be eaten by laws and regulations;

2) the mechanisms of eyesight and memory deterioration of the teenagers and the middle-aged and the elderly are common and different, the blueberry powder compound solid preparation prepared by the invention is suitable for the teenagers and the elderly, and has obvious effects on protecting eyes and improving memory;

3) the blueberry powder compound solid preparation prepared by the invention has no toxic or side effect, is not suitable for infants and pregnant women, and is suitable for various people of different age groups, different physiques and different health conditions;

4) the blueberry powder compound solid preparation prepared by the invention can be used as a raw material or an auxiliary material, and can be prepared into various foods, health-care foods and medicines such as tablets, capsules, granules, oral liquid, hard candies, gel candies, solid beverages, liquid beverages, jellies, baked foods, cakes and the like.

The features and advantages of the present invention will be described in detail by embodiments in conjunction with the accompanying drawings.

[ description of the drawings ]

Fig. 1 is a flow chart of preparation and application of a blueberry powder compound solid preparation.

[ detailed description ] embodiments

The first embodiment is as follows:

weighing 40 parts of blueberry powder, 15 parts of lutein ester, 50 parts of N-acetylneuraminic acid, 40 parts of tea theanine, 0.25 part of curcumin and 35 parts of white fruit powder according to the weight ratio, putting into a mixing container, and uniformly mixing to obtain mixed powder. Subsequently, the obtained mixed powder was subjected to wet granulation or dry granulation and size adjustment to obtain a mixed granule with a mesh size of 10 meshes. Subsequently, the obtained mixed granules were subjected to low-temperature drying at less than 50 ℃, pulverization and sieving, and the mesh number was 120 to obtain a sieved powder. And finally, removing metal foreign matters in the obtained screened powder by an iron remover, carrying out metal detection and inspection after carrying out inner packaging by adopting a food-grade or medicinal-grade PE bag, then carrying out sterilization by adopting an ultrahigh pressure sterilization mode, and carrying out outer packaging to obtain a finished product.

The blueberry powder is prepared by using wild or artificially-planted Ericaceae (Eri-caceae) and Vaccinium spp (Vaccinium spp) blueberry fruits as raw materials, performing pretreatment, extracting (optionally skipping the extraction step), filtering to remove residues, separating and concentrating the filtrate by column chromatography (optionally skipping the separation and concentration step by column chromatography), adding maltodextrin (optionally adding maltodextrin), drying and the like.

The finished product obtained in the steps can be used as a raw material, and can be prepared into common food, health food or medicines after adding a proper amount of auxiliary materials such as food additives, auxiliary agents and the like.

For example, 60 parts of energy-free sweetener and 50 parts of microcrystalline cellulose are added into a blueberry powder compound solid preparation finished product, uniformly mixed and directly filled to prepare hard capsules, granules, powder or solid beverages and the like; ② adding 60 parts of non-energy sweetener, 50 parts of microcrystalline cellulose and 50 parts of magnesium stearate in weight proportion into the finished blueberry powder compound solid preparation, mixing uniformly, and pressing into tablets, tabletting candies, hard candies and the like.

Example two:

weighing 80 parts of blueberry powder, 25 parts of lutein ester, 70 parts of N-acetylneuraminic acid, 70 parts of tea theanine, 2 parts of curcumin and 60 parts of white fruit powder.

The number of the screened meshes is 100 meshes, the sterilization mode is hot water pasteurization, and the other steps are the same as the first embodiment.

The finished product obtained in the steps can be used as a raw material, and can be prepared into common food, health food or medicines after adding a proper amount of auxiliary materials such as food additives, auxiliary agents and the like.

For example, 20 parts by weight of purified water is added into a hot water heating jacket stirring tank and heated to 50 ℃, 34 parts by weight of glycerin fatty acid ester and 250 parts by weight of corn oil are added into a blueberry powder compound solid preparation finished product, after the mixture is uniformly mixed, the mixture is put into the tank and continuously stirred, 168 parts by weight of gelatin is added, after the gelatin is completely dissolved, the mixture is continuously added with 62 parts by weight of glycerin and finally uniformly stirred to serve as a gelatin sandwich material, and a soft capsule, a sugar-free gel candy, a sugar-free jelly, a sugar-free sandwich gel candy, a jam, a baking sauce and the like are prepared on a machine.

Example three:

weighing 90 parts of blueberry powder, 15 parts of lutein ester, 50 parts of N-acetylneuraminic acid, 80 parts of tea theanine, 5 parts of curcumin and 30 parts of white fruit powder.

The number of the screening meshes is 80, and the other steps are the same as those of the first embodiment.

The finished product obtained in the steps can be used as a raw material, and can be prepared into common food, health food or medicines after adding a proper amount of auxiliary materials such as food additives, auxiliary agents and the like.

For example, 1100 parts by weight of purified water is added into a hot water heating jacket stirring tank and heated to 38 ℃, 30 parts by weight of modified soybean lecithin, 15 parts by weight of potassium alginate and 15 parts by weight of magnesium carbonate are added into a blueberry powder compound solid preparation finished product, after the mixture is uniformly mixed, the mixture is added into the tank and is continuously stirred, then 120 parts by weight of non-energetic sweetener, 50 parts by weight of citric acid and 50 parts by weight of L-malic acid are weighed, and are dissolved by 500 parts by weight of purified water and then are added into the tank, the mixture is uniformly stirred, and finally the mixture is filled to prepare oral liquid, liquid beverage and the like.

The above embodiments are illustrative of the present invention, and are not intended to limit the present invention, and any simple modifications of the present invention are within the scope of the present invention.