Okra and turmeric orally disintegrating tablet and preparation method thereof

文档序号：665656 发布日期：2021-04-30 浏览：6次中文

阅读说明：本技术 一种黄秋葵姜黄口崩片及其制备方法 (Okra and turmeric orally disintegrating tablet and preparation method thereof ) 是由植飞田欢华艮闫淇雨杨紫微魏昌华余晓丽徐峰于 2020-12-25 设计创作，主要内容包括：本发明公开一种黄秋葵姜黄口崩片及其制备方法,涉及保健药物技术领域。所述黄秋葵姜黄口崩片包括以下质量分数的组分：黄秋葵姜黄粉、硅化微晶纤维素、抹茶粉、甘露醇、甜菊糖、清凉醇；其中,所述黄秋葵姜黄粉包括黄秋葵粉和姜黄粉。本发明提供的黄秋葵姜黄口崩片,通过上述组分的共同作用,得到了入口即化、清凉可口、口感较好的黄秋葵姜黄口崩片,适合各种人群食用。(The invention discloses an okra and turmeric orally disintegrating tablet and a preparation method thereof, and relates to the technical field of health-care medicines. The okra and turmeric orally disintegrating tablet comprises the following components in percentage by mass: okra and turmeric powder, silicified microcrystalline cellulose, matcha powder, mannitol, stevioside and cooling alcohol; wherein the okra and turmeric powder comprises okra powder and turmeric powder. The okra and turmeric orally disintegrating tablet provided by the invention is instantly melt in the mouth, is cool and delicious, has good mouthfeel and is suitable for various people to eat under the combined action of the components.)

1. The okra and turmeric orally disintegrating tablet is characterized by comprising the following components:

okra and turmeric powder, silicified microcrystalline cellulose, matcha powder, mannitol, stevioside and cooling alcohol; wherein the okra and turmeric powder comprises okra powder and turmeric powder.

2. The okra and turmeric orally disintegrating tablet according to claim 1, wherein the okra and turmeric orally disintegrating tablet comprises the following components in parts by weight:

3. The okra and turmeric orally disintegrating tablet according to claim 2, wherein the okra and turmeric orally disintegrating tablet comprises the following components in parts by weight:

15 parts of okra and turmeric powder, 25 parts of silicified microcrystalline cellulose, 5 parts of matcha powder, 53.5 parts of mannitol, 0.5 part of stevioside and 1 part of cooling alcohol.

4. The okra and turmeric orally disintegrating tablet according to any one of claims 1 to 3, wherein the weight ratio of okra to turmeric in the okra and turmeric powder is (70-80): 5.

5. The okra and turmeric orally disintegrating tablet of claim 1, wherein the particle size of okra and turmeric powder is 60 mesh; and/or the presence of a gas in the gas,

the grain size of the silicified microcrystalline cellulose is 60 meshes; and/or the presence of a gas in the gas,

the particle size of the green tea powder is 60 meshes; and/or the presence of a gas in the gas,

the grain size of the mannitol is 60 meshes; and/or the presence of a gas in the gas,

the grain size of the stevioside is 60 meshes; and/or the presence of a gas in the gas,

the particle size of the cooling alcohol is 60 meshes.

6. A method for preparing the okra and turmeric orally disintegrating tablet according to any one of claims 1 to 5, comprising the steps of:

s10, respectively sieving okra turmeric, stevioside, silicified microcrystalline cellulose, mannitol, matcha powder and menthol, and uniformly mixing to obtain a mixture;

s20, tabletting the mixture to obtain the okra and turmeric orally disintegrating tablet.

7. The method for preparing an okra and turmeric orally disintegrating tablet according to claim 6, wherein in step S10, the sieving is 60 mesh sieving.

8. The method for preparing an okra and turmeric orally disintegrating tablet according to claim 6, wherein in step S10, the mixing method is an equal incremental method.

9. The method for preparing an okra and turmeric orally disintegrating tablet according to claim 6, wherein in step S20, the temperature during tabletting is 25 to 30 ℃.

Technical Field

The invention relates to the technical field of health-care medicines, and in particular relates to an okra and turmeric orally disintegrating tablet and a preparation method thereof.

Background

Okra (Abelmmoschusus esculentus) is also called okra and coffee okra, commonly called cavel and egglena, and is called as 'hot pepper' in Pingxiang province of China in Pingxiang province. The nature is warm, the origin is near the Russian in Africa today and in the tropical zone of Asia, and China has few cultivations. The American is called it 'plant gold okra', which is a good medicine for reducing blood sugar. The okra can be further processed into scented tea, beverage, capsule, dried vegetable, oil, etc. Each part of okra contains hemicellulose, cellulose and lignin. The tender fruit contains abundant proteins, free amino acids, VC, VA, VE, mineral elements such as phosphorus, iron, potassium, calcium, zinc, manganese and the like, and viscous substances such as pectin and polysaccharide. Every 100g of tender fruit contains 2.5g of protein, 0.1g of fat, 2.7g of carbohydrate, 3.9g of crude fiber, 10.2mg of vitamin A, 20.06mg of vitamin B, 44mg of vitamin C, 1.03mg of vitamin E, 0mg of vitamin PPl, 660 International units of vitamin A, 95mg of mineral nutrition potassium, 45mg of calcium, 65mg of phosphorus and 29mg of magnesium.

Turmeric (Latin's name: Curcuma longa L.) also known as Curcuma longa: turmeric root-tuber, Baodingxiang, Chinese ephedra, ginger, etc. The plant height of a perennial herb plant of Curcuma of Zingiberaceae of order Curcuma, which belongs to the order Curcuma, is 1-1.5 m, the rhizome is developed, the root is thick and strong, and the tail end is expanded to form a root tuber; the blades are long round or oval, and the top ends of the blades are short and tapered; the bract is oval or oblong, light green, blunt at the top end, and the corolla is light yellow; the flowering period is 8 months. Turmeric root tuber can promote qi circulation, remove blood stasis, dredge meridians and alleviate pain. It is mainly used for treating chest and abdomen distending pain, shoulder and arm pain, heart pain, postpartum blood pain, initial onset of sore and tinea, irregular menstruation, amenorrhea and traumatic injury, and can extract yellow edible dye with pungent and bitter taste.

However, since okra contains a large amount of vegetable pectin, is difficult to dissolve in water and is sticky and lumpy when meeting water, and turmeric has weak bitter taste, the edible flavor is not good, and many people cannot accept the okra, so that further development and application are limited.

Disclosure of Invention

The invention mainly aims to provide an okra and turmeric orally disintegrating tablet and a preparation method thereof, and aims to solve the problem that the existing okra and turmeric product is poor in taste.

In order to achieve the purpose, the invention provides an okra and turmeric orally disintegrating tablet, which comprises the following components:

Optionally, the okra and turmeric orally disintegrating tablet comprises the following components in parts by mass:

15 parts of okra and turmeric powder, 25 parts of silicified microcrystalline cellulose, 5 parts of matcha powder, 53.5 parts of mannitol, 0.5 part of stevioside and 1 part of cooling alcohol.

Optionally, in the okra and turmeric powder, the mass ratio of okra to turmeric is (70-80): 5.

Optionally, the particle size of the okra and turmeric powder is 60 meshes; and/or the presence of a gas in the gas,

the grain size of the silicified microcrystalline cellulose is 60 meshes; and/or the presence of a gas in the gas,

the particle size of the green tea powder is 60 meshes; and/or the presence of a gas in the gas,

the grain size of the mannitol is 60 meshes; and/or the presence of a gas in the gas,

the grain size of the stevioside is 60 meshes; and/or the presence of a gas in the gas,

the particle size of the cooling alcohol is 60 meshes.

The invention further provides a preparation method of the okra and turmeric orally disintegrating tablet, which comprises the following steps:

s10, respectively sieving okra turmeric, stevioside, silicified microcrystalline cellulose, mannitol, matcha powder and menthol, and uniformly mixing to obtain a mixture;

s20, tabletting the mixture to obtain the okra and turmeric orally disintegrating tablet.

Optionally, in step S10, the sieving is 60 mesh sieving.

Optionally, in step S10, the mixing method is an equal increment method.

Optionally, in step S20, the temperature during tabletting is 25-30 ℃.

According to the okra and turmeric orally disintegrating tablet provided by the invention, the taste of okra and turmeric powder is covered by silicified microcrystalline cellulose, stevioside, matcha powder, mannitol, cooling alcohol and the like, and the silicified microcrystalline cellulose and the mannitol are favorable for forming the orally disintegrating tablet, so that the prepared okra and turmeric product has good mouthfeel, is cool and delicious, and is instantly melt in the mouth. The research finds that the taste of the green tea is similar to that of okra and turmeric powder, and the green tea powder can be added to correct the taste and improve the mouthfeel of okra and turmeric orally disintegrating tablets; mannitol is a kind of hexitol, and has sweet taste due to heat absorption when dissolved, and has comfortable feeling to oral cavity, and cool alcohol can mask bitter taste of medicinal materials; in addition, the mannitol can be mixed with stevioside to greatly improve the flavor of the okra and curcuma longa orally disintegrating tablet; the silicified microcrystalline cellulose has the unique properties of good fluidity and compressibility, good moisture absorption resistance, high load capacity brought by large specific surface area, high disintegration property and the like, so that the silicified microcrystalline cellulose can be used as a functional diluent for direct tabletting; the stevioside has high sweetness and low calorific value, meets the requirement of common people on sweetness, is suitable for patients with diabetes and obesity, and better solves the problem of limited use of special groups such as patients with diabetes and obesity. According to the invention, the dissolution of okra is promoted by silicified microcrystalline cellulose and mannitol, the taste is improved by stevioside, matcha powder, mannitol and cooling alcohol, and the okra and turmeric orally disintegrating tablet which is instantly melt in the mouth, cool and delicious and has good taste is obtained under the combined action of the components, so that the okra and turmeric orally disintegrating tablet is suitable for various crowds to eat.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other related drawings can be obtained according to the drawings without creative efforts.

Fig. 1 is a schematic flow chart of an embodiment of a preparation method of an okra and turmeric orally disintegrating tablet provided by the invention.

The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that those whose specific conditions are not specified in the examples were performed according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially. In addition, the meaning of "and/or" appearing throughout includes three juxtapositions, exemplified by "A and/or B" including either A or B or both A and B. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The okra contains a large amount of plant pectin, is difficult to dissolve in water and is sticky and conglobated after meeting water, and the turmeric has weak bitter taste, so that the okra has poor edible flavor and is difficult to accept by many people, and further development and application are limited.

In view of this, the invention provides an okra and turmeric orally disintegrating tablet, and aims to provide an okra and turmeric product with good mouthfeel.

The okra and turmeric orally disintegrating tablet provided by the invention comprises the following components:

The research finds that the taste of the green tea is similar to that of okra and turmeric powder, and the green tea powder can be added to correct the taste and improve the mouthfeel of okra and turmeric orally disintegrating tablets; mannitol is a kind of hexitol, and has sweet taste due to heat absorption when dissolved, and has comfortable feeling to oral cavity, and cool alcohol can mask bitter taste of medicinal materials; in addition, the mannitol can be mixed with stevioside to greatly improve the flavor of the okra and curcuma longa orally disintegrating tablet; silicified microcrystalline cellulose is a novel pharmaceutic adjuvant obtained by spray drying microcrystalline cellulose and superfine silica gel powder in a ratio of 98: 2, and has the unique properties of good fluidity and compressibility, good moisture absorption resistance, high load capacity brought by large specific surface area, high disintegration property and the like, so that the silicified microcrystalline cellulose can be used as a functional diluent for direct tabletting; the stevioside has the sweetness 200-300 times that of the cane sugar, and the heat value of the stevioside is only 1/300 of the cane sugar, so that the stevioside not only meets the requirement of common people on the sweetness, but also is suitable for patients with diabetes and obesity to take, and better solves the problem of limited use of special people such as the patients with diabetes and obesity. According to the invention, the dissolution of okra is promoted by silicified microcrystalline cellulose and mannitol, the taste is improved by stevioside, matcha powder, mannitol and cooling alcohol, and the okra and turmeric orally disintegrating tablet which is instantly melt in the mouth, cool and delicious and has good taste is obtained under the combined action of the components, so that the okra and turmeric orally disintegrating tablet is suitable for various crowds to eat.

In addition, the oral disintegrating tablet of okra and turmeric provided by the embodiment of the invention has good taste, so that the utilization rate of okra and turmeric is improved, the oral disintegrating tablet of okra and turmeric is convenient to carry and eat, does not need to be taken with water, does not have residue in a cup, and well solves the problems of inconvenience in eating and easiness in waste of the original okra and turmeric powder; okra is also rich in trace elements such as zinc and selenium, and can prevent and resist cancers.

The invention is not limited by the ratio of each component in the okra and turmeric orally disintegrating tablet, and preferably, the okra and turmeric orally disintegrating tablet comprises the following components in parts by weight:

5-15 parts of okra and turmeric powder, 25-35 parts of silicified microcrystalline cellulose, 3-7 parts of green tea powder, 50-60 parts of mannitol, 0.3-1 part of stevioside and 0.5-2 parts of cooling alcohol. Experiments show that the obtained okra and turmeric orally disintegrating tablet has good taste within the above proportioning range.

Further, as the best embodiment of the invention, the okra and turmeric oral disintegrating tablet comprises the following components in parts by weight:

15 parts of okra and turmeric powder, 25 parts of silicified microcrystalline cellulose, 5 parts of matcha powder, 53.5 parts of mannitol, 0.5 part of stevioside and 1 part of cooling alcohol.

In addition, in the embodiment of the invention, the okra and turmeric powder is a mixture of okra powder and turmeric powder, so that all the beneficial effects of okra and turmeric are achieved, the invention is not limited to the proportion of the okra powder and the turmeric powder in the okra and turmeric powder, and in the embodiment of the invention, the weight ratio of the okra to the turmeric is (70-80): 5, so that the obtained okra and turmeric orally disintegrating tablet has balanced nutrition and good mouthfeel.

Further, the particle size of the okra and turmeric powder is 60 meshes; the grain size of the silicified microcrystalline cellulose is 60 meshes; the particle size of the green tea powder is 60 meshes; the grain size of the mannitol is 60 meshes; the grain size of the stevioside is 60 meshes; the particle size of the cooling alcohol is 60 meshes. With the particle size, the obtained okra and turmeric orally disintegrating tablet has good taste. In addition, the particle size conditions of the components can be met simultaneously or only one or more of the above components can be met, and as a preferred embodiment of the invention, the particle sizes of all the components are 60 meshes, so that the compatibility of the components is better.

The invention further provides a preparation method of the okra and turmeric orally disintegrating tablet, which comprises the following steps:

s10, respectively sieving okra turmeric, stevioside, silicified microcrystalline cellulose, mannitol, matcha powder and menthol, and uniformly mixing to obtain a mixture;

in this step, the sieving is preferably a 60 mesh sieve. The obtained orally disintegrating tablet has uniform fineness and good taste after entering the mouth.

In addition, the mixing method is preferably an equivalent addition method, namely grinding a small amount of medicament, adding other fine powder with the same volume, uniformly mixing, increasing the mixing amount by times until the mixture is completely mixed, sieving and mixing. In the formulation, the ingredients are thoroughly mixed and homogenized.

S20, tabletting the mixture to obtain the okra and turmeric orally disintegrating tablet.

Preferably, in the step, the temperature during tabletting is 25-30 ℃. The obtained okra and turmeric orally disintegrating tablet has the advantages of complete and smooth surface, proper hardness, good taste and good flavor.

The following provides an example of a method for preparing the okra and turmeric orally disintegrating tablet of the present invention:

(1) mixing: weighing the raw materials according to the formula, and uniformly mixing okra and turmeric powder, stevioside, silicified microcrystalline cellulose, mannitol, matcha powder and cooling alcohol by sieving with a 60-mesh sieve; wherein the mixing method is an equivalent progressive mixing method.

(2) Tabletting: tabletting the mixture prepared in the step (1) in a single-punch tablet press to obtain okra and turmeric orally disintegrating tablets with complete and smooth surfaces, proper hardness, good taste and good flavor; wherein the tabletting is carried out at 25-30 ℃.

The technical solutions of the present invention are further described in detail below with reference to specific examples and drawings, it should be understood that the following examples are merely illustrative of the present invention and are not intended to limit the present invention.

The amounts of the respective raw materials added in examples 1 to 7 were weighed in the following table 1.

TABLE 1 amounts (parts) of components added

Example 1

(1) Mixing: weighing the raw materials according to the formula, and uniformly mixing okra and turmeric powder, stevioside, silicified microcrystalline cellulose, mannitol, matcha powder and cooling alcohol by sieving with a 60-mesh sieve; wherein the mixing method is an equivalent progressive mixing method, and the mass ratio of the okra to the turmeric in the okra and turmeric powder is 75: 5.

(2) Tabletting: tabletting the mixture prepared in the step (1) in a single-punch tablet press to obtain okra and turmeric orally disintegrating tablets with complete and smooth surfaces and proper hardness; wherein the tabletting is carried out at 25 ℃.

Example 2

(2) Tabletting: tabletting the mixture prepared in the step (1) in a single-punch tablet press to obtain okra and turmeric orally disintegrating tablets with complete and smooth surfaces and proper hardness; wherein the tabletting is carried out at 30 ℃.

Example 3

(2) Tabletting: tabletting the mixture prepared in the step (1) in a single-punch tablet press to obtain okra and turmeric orally disintegrating tablets with complete and smooth surfaces and proper hardness; wherein the tabletting is carried out at 30 ℃.

Example 4

(2) Tabletting: tabletting the mixture prepared in the step (1) in a single-punch tablet press to obtain okra and turmeric orally disintegrating tablets with complete and smooth surfaces and proper hardness; wherein the tabletting is carried out at 28 ℃.

Example 5

(2) Tabletting: tabletting the mixture prepared in the step (1) in a single-punch tablet press to obtain okra and turmeric orally disintegrating tablets with complete and smooth surfaces and proper hardness; wherein the tabletting is carried out at 25 ℃.

Example 6

(2) Tabletting: tabletting the mixture prepared in the step (1) in a single-punch tablet press to obtain okra and turmeric orally disintegrating tablets with complete and smooth surfaces and proper hardness; wherein the tabletting is carried out at 30 ℃.

Example 7

(2) Tabletting: tabletting the mixture prepared in the step (1) in a single-punch tablet press to obtain okra and turmeric orally disintegrating tablets with complete and smooth surfaces and proper hardness; wherein the tabletting is carried out at 28 ℃.

Comparative example 1

The procedure was the same as in example 1 except that the formulation of each component was the same as in comparative example 1 in Table 1.

Comparative example 2

The procedure was the same as in example 1 except that the formulation of each component was the same as that of comparative example 2 in Table 1.

The okra and turmeric orally disintegrating tablets obtained in examples 1 to 7 and comparative examples 1 to 2 were evaluated for satisfaction according to the satisfaction rating table shown in table 1 below.

TABLE 1 evaluation criteria for satisfaction of oral disintegration of okra and turmeric tablets

According to the satisfaction rating table shown in table 1, 90 volunteers of different genders and ages were randomly divided into 9 groups, and the evaluation results of the okra and turmeric orally disintegrating tablets prepared in examples 1 to 7 and comparative examples 1 to 2 were averaged, corresponding to examples 1 to 7 and comparative examples 1 to 2, respectively, and are shown in table 2.

TABLE 2 evaluation results (points) of satisfaction of okra and turmeric orally disintegrating tablets of examples and comparative examples

As can be seen from table 2, the total satisfaction score is 20 points, the scores of the okra and curcuma longa orally disintegrating tablets prepared in examples 1 to 7 are all more than 18 points, silicified microcrystalline cellulose is not added in comparative example 1, mannitol is not added in comparative example 2, and the scores of the silicified microcrystalline cellulose and the mannitol are obviously lower than those of the examples of the present invention, which indicates that the addition of the silicified microcrystalline cellulose and the mannitol is important for the taste of the okra and curcuma longa orally disintegrating tablets, and indicates that the okra and curcuma longa orally disintegrating tablets provided by the present invention have good taste, are suitable for various crowds to eat, and have obvious market competitiveness.

The above is only a preferred embodiment of the present invention, and it is not intended to limit the scope of the invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention shall be included in the scope of the present invention.

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Okra and turmeric orally disintegrating tablet and preparation method thereof

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