阅读说明：本技术 透明防晒剂组合物 (Transparent sunscreen compositions ) 是由 E·马古勇 F·C·孙 于 2020-09-29 设计创作，主要内容包括：本发明题为“透明防晒剂组合物”。本发明提供了一种防晒剂组合物,该防晒剂组合物包含一种或多种油溶性UV过滤剂、至少约20重量％的乙醇、约13.5重量％或更低的粘度为至少20厘沲的低粘度有机硅、以及至少约23重量％的粘度为至多约15厘沲的超低粘度有机硅,其中该组合物是无水的且透明的。(The present invention is entitled "clear sunscreen compositions". The present invention provides a sunscreen composition comprising one or more oil soluble UV filters, at least about 20% by weight ethanol, about 13.5% by weight or less of a low viscosity silicone having a viscosity of at least 20 centistokes, and at least about 23% by weight of an ultra low viscosity silicone having a viscosity of up to about 15 centistokes, wherein the composition is anhydrous and transparent.)

1. A sunscreen composition comprising one or more oil soluble UV filters, at least about 20% by weight ethanol, about 13.5% by weight or less of a low viscosity silicone having a viscosity of at least 20 centistokes, and at least about 23% by weight of an ultra low viscosity silicone having a viscosity of up to about 15 centistokes, wherein the composition is anhydrous and transparent.

2. The composition of claim 1, wherein the UV filter is selected from the group consisting of: homosalate, oxisalate, avobenzone, octocrylene, and mixtures thereof.

3. The composition as claimed in claim 1, wherein the low viscosity silicone is a polydimethylsiloxane having a viscosity of at least 20 centistokes.

4. The composition of claim 1, wherein the ultra-low viscosity silicone is 2 centistokes polydimethylsiloxane (and) trisiloxane.

5. The composition of claim 1, wherein the ultra-low viscosity silicone is an ethyl methicone having a viscosity of 6-15 centistokes.

6. The composition of claim 1, which is substantially free of oxybenzone.

Background

It is well known that prolonged exposure to Ultraviolet (UV) radiation, especially from the sun, can lead to mild skin disease and the formation of erythema and increase the risk of skin cancer, such as melanoma. Exposure to UV radiation also accelerates skin aging, such as loss of skin elasticity and the production of wrinkles. For these reasons, sunscreen compositions are commonly used to provide photoprotection from the sun.

Sunscreen compositions typically include one or more organic sunscreens to provide broad spectrum (UV-a and UV-B) protection. However, the high concentrations of organic sunscreen agents required to provide such protection often impart a greasy feel to the composition. One approach to reduce oiliness is to formulate sunscreen agents using alcohol groups. Alcohol-based sunscreen compositions can provide a pleasant and "clear" visual appearance. On the other hand, if not formulated correctly, alcohol-based sunscreens may have poor phase and viscosity stability, making them cloudy in appearance and unacceptable to consumers.

Silicones are also commonly used in sunscreen compositions to provide a pleasant, non-greasy aesthetic. For example, U.S. patent 8,236,287 relates to an oil-in-water sunscreen composition comprising at least 10% by weight of an organic UV filter, a water insoluble C2-C8 liquid silicone, a branched fatty acid ester of a polycarboxylic acid, and at least 2% by weight of mineral particles having a starch coating applied to their surface. The liquid silicone may be, for example, ethyl methicone, and is used in an amount from about 0.5% to about 10% of the composition.

It has now been found that UV filters, ethanol and high levels of silicone can be used to prepare transparent, aesthetic, alcohol-based sunscreen compositions. This is surprising, since a binary mixture of silicone and ethanol on the one hand and silicone and UV filter on the other hand are usually immiscible. In addition, silicones include a combination of low viscosity and ultra-low viscosity silicones to provide reduced shine on the skin. The composition may additionally be substantially or completely free of oxybenzone while providing surprisingly high SPF.

Disclosure of Invention

The present invention provides a sunscreen composition comprising one or more oil soluble UV filters, at least about 20% by weight ethanol, about 13.5% by weight or less of a low viscosity silicone having a viscosity of at least 20 centistokes, and at least about 23% by weight of an ultra low viscosity silicone having a viscosity of up to about 15 centistokes, wherein the composition is anhydrous and transparent.

Detailed Description

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference.

Where applicable, chemicals are specified according to their INCI names. Additional information, including definitions, suppliers, and trade names, may be found in the appropriate INCI monograph in the 16 th edition of "International cosmetics information dictionary and handbook", published by the Washington Personal Care Products Association (Washington D.C.), or by the Personal Care Products Association's online information base (http:// online.

As used herein, "topical application" means spraying, wiping, applying, or spreading directly on the outer skin or scalp, e.g., with the hand or an applicator (e.g., a wipe, roller, or sprayer).

As used herein, "cosmetic" refers to a beautification substance or article that retains, restores, imparts, stimulates, or enhances the appearance of a body beauty or appears to enhance the appearance or youthful appearance, especially when referring to the appearance of tissue or skin.

As used herein, "sunscreen composition" refers to a formulation (e.g., lotion, spray, gel, or other topical product) that absorbs and/or reflects some of the Ultraviolet (UV) radiation of the sun and thus helps prevent the negative effects of sun exposure (e.g., sunburn, premature aging, etc.).

As used herein, "cosmetically effective amount" means an amount of a physiologically active compound or composition sufficient to treat one or more conditions, but sufficiently low to avoid serious side effects. The cosmetically effective amount of the compound or composition will vary depending on the following factors: the condition being treated, the age and physical condition of the end user, the severity of the condition being treated/prevented, the duration of the treatment, the nature of the other treatment, the particular compound or product/composition employed, the cosmetically acceptable carrier utilized, and the like.

As used herein, "cosmetically acceptable" means that the ingredients described by the term are suitable for use in contact with tissue (e.g., skin) without undue toxicity, incompatibility, instability, irritation, allergic response, and the like.

As used herein, a "cosmetically acceptable active agent" is a compound (synthetic or natural) that has a cosmetic or therapeutic effect on the skin.

As used herein, "treating or treating" refers to reducing, preventing, ameliorating, or eliminating the presence or signs of a condition or disorder.

As used herein, "phase stability" means maintaining interfacial stability or suspension stability or both at each of 25 ℃, 40 ℃ and 50 ℃ temperatures for at least 2 weeks. "interfacial stability" refers to the stability against coalescence and coarsening of discontinuous phases in a composition having two or more phases. By "suspension stability" is meant stability against creaming and/or settling of a discontinuous phase (e.g., solids) suspended in a continuous phase.

By "transparent" is meant free of undissolved particles and clear as determined by visual inspection using a 20mL glass scintillation vial.

As used herein, "substantially free" means that the referenced ingredients are not added directly and intentionally to the formulation. Preferably, "substantially free" means containing less than about 1% of the ingredient. More preferably, "substantially free" means containing less than about 0.5% of the ingredient. Even more preferably, "substantially free" means containing less than about 0.1% by weight of the ingredient. The composition may be completely free of ingredients, i.e. free of any ingredients.

Unless otherwise indicated, percentages or concentrations refer to weight percentages or weight concentrations (i.e., (weight/weight)). Unless otherwise stated, all ranges are inclusive, e.g., "4 to 9" includes the endpoints 4 and 9.

UV filter

The composition comprises one or more oil soluble UV filters.

As used herein, "organic UV filter" means an organic molecule capable of absorbing UV light, including: (i) an aromatic compound conjugated with a carbonyl moiety substituted ortho or para to the aromatic ring, and (ii) a polymer made from organic chromophores attached to polymer chains, either of which blocks or absorbs Ultraviolet (UV) light.

Conventional organic UV filters are small aromatic molecules with molecular weight values<900 g/mol. Examples of organic non-polymeric UV filters include, but are not limited to: methoxycinnamate derivatives such as octyl methoxycinnamate and isoamyl methoxycinnamate; camphor derivatives such as 4-methylbenzylidene camphor, camphorbenzalkonium methyl sulfate and p-xylylene dicamphor sulfonic acid; salicylate derivatives such as octyl salicylate, ethylhexyl salicylate, and homosalate; benzoin derivatives such as dioxybenzone and oxybenzone; benzoic acid derivatives such as aminobenzoic acid and octyldimethyl-p-aminobenzoic acid; octocrylene and other beta, beta-diphenylacrylates; dioctyl butamido triazone; octyl triazone; avobenzone (butyl methoxydibenzoylmethane); menthyl anthranilate; triazinone derivatives, such as ethylhexyl triazinone (A), (B), (C)T150); diethylhexyl butamido triazone(s) ((R))HEB); bis (ethylhexyloxyphenol methoxyphenyl) triazine (S), benzoate derivatives such as diethylaminohydroxybenzoylbenzoic acid hexyl ester (S) ((R)APlus), benzotriazole derivatives such as cresoltrazol trisiloxane (C: (C)XL), methylenebis-benzotriazolyl tetramethylbutylphenol (b)M); a terphenyl triazine; (2- {4- [2- (4-diethylamino-2-hydroxybenzoyl) -benzoyl]-piperazine-1-carbonyl } -phenyl) - (4-diethylamino-2-hydroxy-phenyl) -methanone; a merocyanine derivative; bis (butylbenzoate) diaminotriazine aminopropyl siloxane; and bis-ethylhexyloxyphenol methoxyphenyl triazine, which are encapsulated in a polymer matrix.

Polymeric organic UV filters are polymers made of organic chromophores bonded to a polymer chain, e.g. having e.g. an average molecular weight>A polysiloxane chain of 6000 daltons. Examples of such polysiloxane UV filters include, but are not limited toSLX and polyorganosiloxane-15. UVB (. lamda.) of the absorption spectra of these polysiloxanes_max312nm) and is typically combined with UVA filters to achieve broad spectrum protection.

The following table lists various commercially available organic UV filters.

The sunscreen composition may comprise at least about 10% by weight of one or more oil-soluble UV filters, based on the total weight of the composition. The composition may comprise from about 15 wt% to about 35 wt% of one or more oil-soluble UV filters, based on the total weight of the composition. The composition may comprise at least about 21% by weight, based on the total weight of the composition, of one or more oil-soluble filters, particularly when a clear composition is desired.

The oil soluble UV filter can be selected from one or more of homosalate, oxisal, avobenzone, and octocrylene.

The oil soluble UV filter can be mixture of homosalate, oxisal, avobenzone, and octocrylene. For example, a sunscreen composition may comprise homosalate in an amount of from about 8 to about 15% by weight, oxisalate in an amount of from about 4 to about 5% by weight, avobenzone in an amount of from about 2 to about 3% by weight, and octocrylene in an amount of from about 7 to about 10% by weight, based on the total weight of the composition.

The sunscreen composition may be substantially free of oxybenzone. The sunscreen composition may be completely free of oxybenzone.

The composition may optionally contain one or more UV blockers, which are compounds that reflect, absorb or scatter UV radiation. When present in sunscreen compositions, they reflect ultraviolet, visible, and infrared light to enhance sunscreen. UV blockers are typically inorganic metal oxides including titanium dioxide, zinc oxide, and certain other transition metal oxides. Such UV blockers are typically solid particles in micronized or nanosized form having a diameter of about 0.01 microns to about 10 microns.

Examples include zinc oxide, titanium dioxide, doped zinc oxide, doped titanium dioxide, and other transition metal oxides. Doped metal oxides contain dopants which are trace elements of other metal atoms incorporated into the primary metal oxide lattice to alter its electrical or optical properties, and may contain aluminum, manganese and iron.

In another embodiment, the metal oxide comprises coated particles. The coating may comprise, for example, a hydrophobic material such as an alkyl siloxane (e.g., triethoxyoctylsilane), a silicone, or a metal salt of a fatty acid.

In one embodiment, the metal oxide comprises particles having a diameter of about 0.01 microns to about 10 microns.

In one embodiment, the inorganic sunscreen agent may also comprise particulate doped zinc oxide, as described in US9144535, US9144536 and WO2008117017, which are incorporated herein by reference in their entirety. Such particulate zinc oxide contains low levels of certain dopants at specific ratios and provides improved performance in terms of absorption in the UVA portion of the electromagnetic spectrum. The particulate zinc oxide comprises a cationic portion which in turn comprises about 99% or more by weight of zinc moieties. The cationic moiety also includes a first dopant moiety and a second dopant moiety, which comprise metals such as manganese, iron, aluminum, and copper. The first dopant moiety and the second dopant moiety may be present in an amount of about 0.1% to about 0.75% by weight of the cationic moiety. The particulate doped zinc oxide may also contain low concentrations of additional metal cations, such as cations of alkali metals, alkaline earth metals, other transition metals, and cations of metals such as gallium, germanium, gallium, indium, tin, antimony, thallium, lead, bismuth, and poloxamer.

These doped zinc oxides can be prepared by various methods, such as by reducing the oxide ore using, for example, carbon or other suitable reducing agents, followed by reoxidation. Other suitable methods include wet chemical methods. One example of a wet chemical process includes mixing alkaline salt solutions of various cations and precipitating ZnO by lowering the pH using an acid such as oxalic acid or formic acid. A particularly suitable wet-chemical process is the so-called "sol-gel" process.

SPF

Sun Protection Factor (SPF) can be tested using the following in vitro SPF test method. Baseline transmittance of PMMA plate (substrate, available from Helioscience, Marseille, France) calibrated usingUV-10005UV transmission analyzer orUV-2000S Transmission analysisThe UV absorbance was measured by an instrument (Labsphere, North Sutton, N.H., USA). Then rubbed into a uniform thin layer by the operator's finger, using about 1.3mg/cm²The test sample is applied to a PMMA plate. The sample was allowed to dry for 15 minutes and then the UV absorbance was measured in the same manner. Using absorbance measurements known in the art, SPF was calculated using the following formula:

wherein:

e (lambda) ═ erythema action Spectrum

I (λ) ═ spectral irradiance received from a UV source

A₀(λ) ═ average monochromatic absorbance of the test product layers prior to UV exposure; and is

d (λ) ═ wavelength stepping (1 nm).

In one embodiment, the composition has an SPF of at least about 15 as measured by the in vitro SPF test method. In another embodiment, the composition has an SPF of at least about 25 as measured by the in vitro SPF test method.

The composition may comprise one or more SPF boosters, such as styrene/acrylate copolymers. A commercially available styrene/acrylate copolymer is sunphases Powder from Dow Chemical.

Film forming agent

Film formers are typically polymers that: when dissolved in the composition, allows for the formation of a continuous or semi-continuous film when the composition is spread onto, for example, a smooth glass and the liquid carrier is allowed to evaporate. Thus, the polymer should dry on the glass in a predominantly continuous manner, rather than forming a plurality of discrete island structures. Generally, the average thickness of the film formed by applying the sunscreen composition to the skin according to the present invention is less than about 100 microns, such as less than about 50 microns.

Suitable film-forming polymers include natural polymers such as polysaccharides or proteins, and synthetic polymers such as polyesters, polyacrylates, polyurethanes, vinyl polymers, polysulfonates, polyureas, polyoxazolines, and the like. Specific examples of film-forming polymers include, for example, acrylic homopolymers or copolymers having hydrophobic groups, such as acrylate/octylacrylamide copolymers, including DERMACRYL 79 available from Akzo Chemical (Bridgewater, n.j.); acrylate/polydimethylsiloxane acrylate copolymers available as X-22-8247D from Shin-Etsu (Japan); hydrogenated dimer gum/dimethyl carbonate copolymer, available as X-22-8247D from BASF Corp.; copolymers of vinyl pyrrolidone and long chain alpha-olefins, such as those commercially available as GANEX V220 from Ashland Specialty additives; vinylpyrrolidone/myricyl (tricontanyl) copolymer, also available from Ashland as GANEX WP 660; water dispersible polyesters, including sulfopolyesters, such as those commercially available as EASTMAN AQ 38S from Eastman Chemical. In certain embodiments, the film-forming polymer is water-insoluble, but becomes soluble upon exposure to an alkaline substance so as to facilitate removal from the skin upon washing with soap.

The total amount of film former in the composition may range from about 0.25% to about 15% by weight of the composition, based on the total weight of the composition. The total amount of film former in the composition may range from about 0.5% to about 10% by weight of the composition, based on the total weight of the composition. The total amount of film former in the composition may range from about 1% to about 5% by weight of the composition, based on the total weight of the composition.

Low viscosity silicones

The composition contains one or more low viscosity silicones. Silicones, also known as polysiloxanes, are polymers made from repeating units of siloxanes, alternating chains of silicon and oxygen atoms combined with carbon, hydrogen and sometimes other elements.

The low viscosity silicone should have a minimum viscosity that does not evaporate in an open system. The low viscosity silicone may have a viscosity of at least 20 centistokes. The low viscosity silicone may have a viscosity of at least 50 centistokes. The low viscosity silicone may have a viscosity of at least 100 centistokes.

As used herein, "viscosity" means kinematic viscosity, which is a measure of the volumetric flow of a liquid, defined as stroke (St). A centistokes, cSt 0.01St 1mm²And/sec. "ASTM name: D4283-98-Standard Test Method for Viscosity of Silicone Fluids "can be used to determine Viscosity. In this test method, it is recommended to use an Ostwald viscometer (up to 5,000cst), an Ubbelohde viscometer (up to 100,000cst), or a Cannon Fenski viscometer (up to 5,000cst) in the determination of the kinematic viscosity.

The low viscosity silicone may be a polydimethyl silicone having a viscosity of at least 20 centistokes. The low viscosity silicone may be a polydimethyl silicone having a viscosity of at least 50 centistokes. The low viscosity silicone may be a polydimethyl silicone having a viscosity of at least 100 centistokes.

Polydimethylsiloxanes with viscosities of 20 or 50 or 100 centistokes are commercially available, for example, from the Dow Chemical Company (Midland, MI).

The amount of low viscosity silicone in the composition can range up to about 13.5 weight percent of the total weight of the composition. The amount of the low viscosity silicone in the composition can range from about 1 wt.% to about 13.5 wt.% based on the total weight of the composition.

Ultra-low viscosity silicones

Ultra-low viscosity silicones are characterized by their rapid evaporation rate. Also silicone or polysiloxane, having a viscosity of up to about 15 centistokes. The ultra-low viscosity silicone may have a viscosity of up to about 6 centistokes. The ultra-low viscosity silicone may have a viscosity of up to about 2 centistokes. The viscosity is kinematic viscosity and can be measured as described above.

The ultra-low viscosity silicone may be linear rather than cyclic.

The ultra-low viscosity silicone may be 2 centistokes polydimethylsiloxane (and) trisiloxane. The two centistoke polydimethylsiloxanes (and) trisiloxanes are commercially available from the Dow Chemical Company (Midland, Mich.).

The ultra-low viscosity silicone may be an ethyl methicone having a viscosity of from 6 centistokes to 15 centistokes. Such ethyl methicones are commercially available from Siltech Corp (Toronto, Canada).

The amount of ultra-low viscosity silicone in the composition can be at least about 23 weight percent of the total weight of the composition. The amount of the ultra-low viscosity silicone in the composition can range from about 23 wt% to about 58 wt%, based on the total weight of the composition.

Ethanol

The sunscreen composition is anhydrous. The composition may be substantially free of water. The composition may be completely free of water.

The sunscreen composition comprises ethanol.

The composition may comprise at least about 20% by weight ethanol. The composition may comprise at least about 25% by weight ethanol. The composition may comprise at least about 30% by weight ethanol.

Topical compositions

The compositions may be prepared using mixing and blending methods well known in the sunscreen and cosmetic arts.

The composition may be combined with a "cosmetically acceptable topical carrier", i.e., a topical carrier capable of containing other ingredients dispersed or dissolved therein and having acceptable properties that render it safe for topical use.

The cosmetically acceptable topical carrier may optionally contain a wide variety of additional oil-soluble and/or oil-dispersible materials commonly used in compositions for application to the skin at levels established in the art. For example, surfactants, emulsifiers, pearlizing or opacifying agents, thickeners, emollients, conditioning agents, humectants, chelating agents, exfoliants, preservatives, pH adjusters, and additives that enhance the appearance, feel, or smell of the composition, such as colorants, fragrances, tactile modifiers, and the like, may be included.

The composition may optionally contain additional film forming agents such as natural polymers, such as polysaccharides or proteins, and synthetic polymers, such as other polyesters, polyacrylates, polyurethanes, vinyl polymers, polysulfonates, polyureas, polyoxazolines, and the like. Specific examples include acrylate/polydimethylsiloxane acrylate copolymers (commercially available as X-22-8247D from Shin-Etsu (Japan)); hydrogenated dimer diliylene-dimethyl carbonate copolymer (commercially available as COSMEDIADC from BASF corp.); copolymers of vinyl pyrrolidone and long chain alpha-olefins, such as those commercially available as GANEX V220 from Ashland Specialty additives; vinylpyrrolidone/myricyl (tricontanyl) copolymer, also commercially available from Ashland as GANEX WP 660.

Suitable emollients include mineral oil, petrolatum, vegetable oils (e.g., triglycerides such as caprylic/capric triglyceride), waxes, other mixtures of fatty esters including, but not limited to, esters (e.g., isopropyl palmitate, isopropyl myristate, diisopropyl adipate, dibutyl adipate, dioctyl carbonate, C12-15 alkyl benzoates)), silicone oils (such as polydimethylsiloxane), and alkanes (such as isohexadecane).

In certain embodiments, the composition comprises a pigment suitable for providing color or hiding power. The pigment may be a pigment suitable for use in a coloured cosmetic product, including a composition for application to hair, nails and/or skin, especially the face. Color cosmetic compositions include, but are not limited to, foundations, concealers, primers, blushes, mascaras, eye shadows, eyeliners, lipsticks, nail polish, and toning moisturizers. Pigments suitable for providing color or hiding power may be comprised of iron oxides (including red and yellow iron oxides), titanium dioxide, ultramarine pigments, and chromium or chromium hydroxide color particles, and mixtures thereof. The pigment may be a lake pigment, for example, an organic dye such as azo, indigo, triphenylmethane, anthraquinone, and xanthine dyes designated as D & C and FD & C blue, brown, green, orange, red, yellow, and the like, precipitated onto an inert binder such as an insoluble salt. Examples of lake pigments include Red #6, Red #7, Yellow #5, Violet #2, and Blue # 1. The pigment may be an interference pigment. Examples of interference pigments include those comprising a mica substrate, a bismuth oxychloride substrate, and a silica substrate, such as mica/bismuth oxychloride/iron oxide pigments commercially available as CHROMALITE pigments (BASF); titanium dioxide and/or iron oxide coated on mica, such as the commercially available FLAMENCO pigment (BASF); mica/titanium dioxide/iron oxide pigments including commercially available KTZ pigments (Kobo products), CELLINI pearl pigment (BASF); and borosilicate containing pigments such as REFLECKS pigments (BASF).

In one embodiment, the composition comprises a humectant, such as butylene glycol or glycerin. The composition may comprise, for example, at least about 1.0 wt% humectant.

The composition may also contain one or more other cosmetically acceptable active agents including, for example, anti-acne agents, shine control agents, antimicrobial agents, anti-inflammatory agents, antifungal agents, antiparasitic agents, external analgesics, antioxidants, keratolytic agents, moisturizers, nutrients, vitamins, energizers, antiperspirants, astringents, deodorants, solidifying agents, anti-stiffness agents, and agents for skin conditioning.

Amounts of other cosmetically active agents may range from about 0.001% to about 20% by weight of the composition, for example, from about 0.005% to about 10% by weight of the composition, such as from about 0.01% to about 5% by weight of the composition.

Cosmetically acceptable active agents may be selected from, for example, D-panthenol carotenoids, ceramides, polyunsaturated fatty acids, essential fatty acids, enzymes such as laccase, enzyme inhibitors, minerals, steroids such as hydrocortisone, 2-dimethylaminoethanol, copper salts such as copper chloride, polypeptides such as hexapeptides, trispeptides, and those containing copper, coenzyme Q10, amino acids such as proline, vitamins, lactobionic acid, acetyl-coa, niacin, riboflavin, thiamine, ribose, electron transport proteins such as NADH and FADH2, natural extracts such as from aloe, feverfew, oatmeal, dill, blackberry, paulownia, pichia pastoris (pichia anomala), and chicory, resorcinols such as 4-hexylresorcinol, curcuminoids, sugar amines such as N-acetyl glucosamine, and derivatives and mixtures thereof.

Examples of vitamins include, but are not limited to, vitamin a, vitamin B groups (such as vitamin B3, vitamin B5, and vitamin B12), vitamin C, vitamin K, and different forms of vitamin E (like alpha, beta, gamma, and delta tocopherols or mixtures thereof), and derivatives thereof.

Examples of antioxidants include, but are not limited to, water-soluble antioxidants such as sulfhydryl compounds and derivatives thereof (e.g., sodium metabisulfite and N-acetyl-cysteine), lipoic acid and dihydrolipoic acid, resveratrol, lactoferrin, and ascorbic acid derivatives (e.g., ascorbyl palmitate and ascorbyl polypeptide). Oil-soluble antioxidants suitable for use in the compositions of the present invention include, but are not limited to, butylated hydroxytoluene, retinoids (e.g., retinol and retinyl palmitate), tocopherols (e.g., tocopheryl acetate), tocotrienols, and ubiquinone. Natural extracts containing antioxidants suitable for use in the compositions of the present invention include, but are not limited to: extracts containing flavonoids and isoflavones and their derivatives (e.g., genistein and lignoisonol (diadzein)), extracts containing resveratrol, and the like. Examples of such natural extracts include grape seed, green tea, pine bark, and propolis.

Sprayability

The compositions of the present invention are sprayable. As used herein, "sprayable" means that the composition produces an evenly distributed and reproducible spray pattern over an area of defined shape (e.g., circular, annular) and size when manually actuated or released by pressurization from a dispensing mechanism such as a bottle or aerosol can having a pump spray nozzle. The composition may be sprayable without the use of a propellant, i.e., in a non-aerosol form.

The following non-limiting examples further illustrate the invention.

Example 1

A series of compositions were prepared using 30 wt% ethanol, polydimethylsiloxane (20cst), polydimethylsiloxane (and) trisiloxane, and the other ingredients shown in table 1. Compositions 1-6 are compositions according to the invention and compositions a and B are comparative compositions.

TABLE 1

Another series of compositions was prepared using 30 wt% ethanol, polydimethylsiloxane (20cst), ethyl methicone, and other ingredients shown in table 2. Compositions 7-9 are compositions according to the invention and compositions C-G are comparative compositions.

TABLE 2

The composition was prepared as follows.

Main phase: ethanol, otisalate, homosalate and octocrylene were added to the main vessel and mixing was started at 300 rpm. While mixing, the acrylate/octylacrylamide copolymer and avobenzone were added and stirred until homogeneous. Once homogeneous, polydimethylsiloxane was added; acrylate/dimethicone copolymer, dimethicone (and) trisiloxane or ethylmethicone (if appropriate), diisopropyl adipate, and tocopheryl acetate (if appropriate), and mixing continued. Once clear, polydimethylsiloxane (20cst) was added with continuous mixing.

The compositions were tested for clarity. Clarity was determined by visual observation using a 20mL glass scintillation vial. The composition according to the invention is free of insoluble particles and is clear. The comparative composition was cloudy and unstable.

The results are shown in Table 3.

TABLE 3

Compositions 1-6 according to the invention containing a combination of at most 13.5% by weight of polydimethylsiloxane (20cst) and at least 23.3% by weight of polydimethylsiloxane (and) trisiloxane according to the invention are clear. However, comparative compositions a and B containing more than 13.5 wt% polydimethylsiloxane (20cst) were unstable and turbid.

Similarly, compositions 7-9 according to the invention containing a combination of at most 4% by weight of polydimethylsiloxane (20cst) and at least 32% by weight of ethylmethicone are also clear. However, when the concentration of polydimethylsiloxane (20cst) exceeded 4%, the composition became cloudy as shown by comparative compositions C-G.

Example 2

A series of compositions were prepared using 30 wt% ethanol, polydimethylsiloxane (50cst), polydimethylsiloxane (and) trisiloxane or ethylmethicone, and the other ingredients shown in table 4. Compositions 10-14 are compositions according to the invention and compositions H-J are comparative compositions.

TABLE 4

The composition was prepared as follows.

Main phase: ethanol, otisalate, homosalate and octocrylene were added to the main vessel and mixing was started at 300 rpm. While mixing, the acrylate/octylacrylamide copolymer and avobenzone were added and stirred until homogeneous. Once homogeneous, polydimethylsiloxane was added; acrylate/polydimethylsiloxane copolymer, polydimethylsiloxane (and) trisiloxane or ethylmethicone (if appropriate), diisopropyl adipate, and mixing was continued. Once clear, polydimethylsiloxane (50cst) was added with continuous mixing.

The compositions were tested for clarity as described in example 1.

The results are shown in Table 5.

TABLE 5

Compositions 10-13 according to the invention containing a combination of up to 9% by weight of polydimethylsiloxane (50cst) and at least 31% by weight of polydimethylsiloxane (and) trisiloxane according to the invention are clear.

Similarly, a composition 14 according to the invention containing a combination of 2.5% by weight of polydimethylsiloxane (50cst) and 31% by weight of ethylmethicone is also clear.

However, comparative composition H, which contained 10 wt% polydimethylsiloxane (50cst), 31 wt% polydimethylsiloxane (and) trisiloxane, was cloudy. Comparative composition HH-J (50cst) containing 31 wt.% ethyl methicone with 3 wt.%, 4 wt.% and 5 wt.% dimethicone was also cloudy.

Example 3

A series of compositions were prepared using 30 wt% ethanol, dimethicone (100cst), dimethicone (and) trisiloxane or ethyl methicone, and other ingredients shown in table 6. Composition 15 is a composition according to the invention and compositions K-S are comparative compositions.

TABLE 6

The composition was prepared as follows.

Main phase: ethanol, otisalate, homosalate and octocrylene were added to the main vessel and mixing was started at 300 rpm. While mixing, the acrylate/octylacrylamide copolymer and avobenzone were added and stirred until homogeneous. Once homogeneous, polydimethylsiloxane was added; acrylate/dimethicone copolymer, dimethicone (and) trisiloxane or ethylmethicone (if appropriate), diisopropyl adipate, and tocopheryl acetate (if appropriate), and mixing continued. Once clear, polydimethylsiloxane (100cst) was added with continuous mixing.

The compositions were tested for clarity as described in example 1.

The results are shown in Table 7.

TABLE 7

The composition 15 according to the invention, containing only 31% by weight of polydimethylsiloxane (and) trisiloxane and polydimethylsiloxane (100cst), is clear.

Example 4

A series of compositions were prepared using 25 wt% ethanol, polydimethylsiloxane (20cst), polydimethylsiloxane (and) trisiloxane or ethylmethicone, and the other ingredients shown in table 8. Compositions 16-18 are compositions according to the invention and compositions T-W are comparative compositions.

TABLE 8

The composition was prepared as follows.

Main phase: ethanol, otisalate, homosalate and octocrylene were added to the main vessel and mixing was started at 300 rpm. While mixing, the acrylate/octylacrylamide copolymer and avobenzone were added and stirred until homogeneous. Once homogeneous, polydimethylsiloxane was added; acrylate/dimethicone copolymer, dimethicone (and) trisiloxane or ethylmethicone (if appropriate), diisopropyl adipate, and tocopheryl acetate (if appropriate), and mixing continued. Once clear, polydimethylsiloxane (20cst) was added with continuous mixing.

The compositions were tested for clarity as described in example 1.

The results are shown in Table 9.

TABLE 9

As shown in table 9, the combination of 25% ethanol and dimethicone (and) trisiloxane can dissolve up to 7% by weight of dimethicone (20cst), so the sunscreen composition remains clear and exhibits good aesthetic feel, as shown by compositions 16-18. When the concentration of polydimethylsiloxane (20cst) exceeded 7%, the sunscreen formulation was unstable and became cloudy as shown by composition T-V. The combination of 25% ethanol and ethyl methicone was unable to dissolve 5% by weight of dimethicone (20cst), as shown in composition W.

Example 5

A series of compositions were prepared using 20 or 25 wt% ethanol, dimethicone (20cst or 50cst or 100cst), dimethicone (and) trisiloxane, and other ingredients shown in table 10. Compositions 19-21 are compositions according to the invention and compositions X-ZZ are comparative compositions.

Watch 10

The composition was prepared as follows.

Main phase: ethanol, otisalate, homosalate and octocrylene were added to the main vessel and mixing was started at 300 rpm. While mixing, the acrylate/octylacrylamide copolymer and avobenzone were added and stirred until homogeneous. Once homogeneous, polydimethylsiloxane was added; acrylate/dimethicone copolymer, dimethicone (and) trisiloxane, diisopropyl adipate, and tocopherol acetate (if appropriate), and mixing continued. Once clear, the appropriate polydimethylsiloxane (20cst, 50cst, or 100cst) was added with continuous mixing.

The compositions were tested for clarity as described in example 1.

The results are shown in Table 11.

TABLE 11

As shown in table 11, the combination of 25% ethanol and dimethicone (and) trisiloxane can dissolve up to 5% by weight of dimethicone (50cst) and up to 4% by weight of dimethicone (100cst), such that the sunscreen composition remains clear and exhibits good aesthetic feel, as shown by compositions 19-21. When the concentration of polydimethylsiloxane (50cst) exceeds 6% or the concentration of polydimethylsiloxane (100cst) exceeds 5%, the sunscreen formulation is unstable and becomes cloudy as shown by compositions X and Y. Furthermore, the combination of 20% ethanol and polydimethylsiloxane (and) trisiloxane did not dissolve 1% by weight of polydimethylsiloxane (20cst), as shown by composition Z-ZZ.