阅读说明：本技术 适用于银屑病患者皮肤护理的聚桂醇洗发水及其制备方法 (Polycinnamic alcohol shampoo suitable for skin care of psoriasis patients and preparation method thereof ) 是由 杨军营 于 2020-12-21 设计创作，主要内容包括：本发明涉及适用于银屑病患者皮肤护理的聚桂醇洗发水及其制备方法,所述洗发水包含以下重量份的组分：泛醇0.1份-1.5份；甘油1份-5份；聚桂醇1份-3份；氯咪巴唑0.1份-1.5份。本发明的洗发水作为非离子型表面活性剂起到乳化、分散、清洁、润湿的作用,能解决银屑病患者的日常头皮护理问题,起到保湿、去屑、止痒的作用,配方中特别包含聚桂醇,具有轻微麻醉作用,作为外用头皮护理制剂不但能促进头皮角质软化,且能迅速止痒、去屑。(The invention relates to a poiyguyl shampoo suitable for skin care of patients with psoriasis and a preparation method thereof, wherein the shampoo comprises the following components in parts by weight: 0.1 to 1.5 portions of panthenol; 1-5 parts of glycerol; 1-3 parts of lauromacrogol; 0.1 to 1.5 portions of climbazole. The shampoo disclosed by the invention has the effects of emulsifying, dispersing, cleaning and moistening as a nonionic surfactant, can solve the daily scalp care problem of patients with psoriasis, and has the effects of moisturizing, removing dandruff and relieving itching.)

1. Polycinnamic alcohol shampoo suitable for skin care of patients with psoriasis is characterized in that:

the shampoo comprises the following components in parts by weight:

0.1 to 1.5 portions of panthenol;

1-5 parts of glycerol;

1-3 parts of lauromacrogol;

0.1 to 1.5 portions of climbazole.

2. The poiyurenol shampoo for the skin care of patients with psoriasis according to claim 1 wherein:

the shampoo also comprises the following components in parts by weight:

100.1 to 2.5 portions of polyquaternium;

15-30 parts of sodium laureth sulfate;

coco glucoside and glyceryl oleate 3-8 parts.

3. The poiyurenol shampoo for the skin care of patients with psoriasis according to claim 2, wherein:

the shampoo also comprises the following components in parts by weight:

0.1 to 1.5 portions of DMDM hydantoin;

1-3 parts of sodium dilinoleidopropyl PG-dimethyl ammonium chloride phosphate;

0.1 to 1.5 portions of EDTA-disodium;

0.1 to 0.5 portion of ethylene glycol distearate;

1-5 parts of acrylic acid (ester) crosslinked polymer.

4. The poiyurenol shampoo for the skin care of patients with psoriasis according to claim 3 wherein:

the shampoo also comprises the following components in parts by weight:

1-5 parts of potassium hydroxide;

1-5 parts of cocamidopropyl betaine.

5. The poiyurenol shampoo for the skin care of patients with psoriasis according to claim 4, wherein:

the shampoo is prepared from 100 parts by weight of water at constant volume.

6. The method of preparing a poiyurenol shampoo suitable for scalp care of patients with psoriasis according to claim 5 wherein:

the method comprises the following steps:

the method comprises the following steps: adding the phase A into an emulsifying pot, and uniformly stirring; the phase A comprises: water;

step two: adding the phase B into a main boiler, heating and uniformly stirring; the phase B comprises: polyquaternium-10, sodium laureth sulfate, coco glucoside, glyceryl oleate, EDTA-disodium, ethylene glycol distearate;

step three: dissolving phase C, adding into a main pot, stirring uniformly, heating, adding phase D, and stirring; the phase C comprises: acrylic crosslinked polymers; phase D comprises: potassium hydroxide;

step four: cooling, adding the phase E, and uniformly stirring; phase E comprises: panthenol;

step five: cooling, sequentially adding F, G, H, I, J phases, stirring uniformly, and discharging after the inspection is qualified; the phase F comprises: glycerol, DMDM hydantoin; G. h, I, J phases are: dilinoleidopropyl PG-dimethyl ammonium chloride sodium phosphate, lauromacrogol, climbazole and cocamidopropyl betaine.

7. The method for preparing a poiyurenol shampoo suitable for scalp care of patients with psoriasis according to claim 6 wherein:

in the second step, the temperature is raised to 80 ℃, and the mixture is dissolved and stirred uniformly.

8. The method for preparing a poiyurenol shampoo suitable for scalp care of patients with psoriasis according to claim 7 wherein:

in the third step, stirring is carried out for 20 minutes, the homogenizing rotation speed is 2800 revolutions per minute, and the temperature is increased to 75 ℃.

9. The method for preparing a poiyurenol shampoo suitable for scalp care of patients with psoriasis according to claim 8, wherein the method comprises the following steps:

in step four, the mixture was cooled to 45 ℃ and stirred for 5 minutes.

10. The method for preparing a poiyurenol shampoo suitable for scalp care of patients with psoriasis according to claim 9, wherein the method comprises the following steps:

and step five, cooling to 30 ℃, stirring for 5 minutes, and discharging.

Technical Field

The invention relates to a skin cleaning product, and particularly relates to a polycinnamic alcohol shampoo suitable for skin care of patients with psoriasis and a preparation method thereof.

Background

According to statistics of relevant data, the total disease rate of psoriasis in China is 0.25%, namely about 325 thousands of people suffer from psoriasis with different degrees. The biggest symptoms of psoriasis patients are dry, flaky and itchy skin of the whole body including skin, but 60% of psoriasis patients have repeated disease conditions due to improper daily care, so the daily care is very important while treating.

Common cosmetics and body washing and bathing products are suitable for normal skin, but patients with skin diseases can suffer from repeated illness state after using the common products, so that the patients suffer from pain. Common cosmetics are abundant in the market, and the daily nursing requirement of skin patients cannot be met.

Disclosure of Invention

The invention aims to provide a polycinnamic alcohol shampoo suitable for skin care of patients with psoriasis and a preparation method thereof, which solve the problem of daily skin care of the patients with psoriasis and have the effects of removing dandruff and relieving itching.

The technical scheme adopted by the invention is as follows:

polycinnamic alcohol shampoo suitable for skin care of patients with psoriasis is characterized in that:

the shampoo comprises the following components in parts by weight:

0.1 to 1.5 portions of panthenol;

1-5 parts of glycerol;

1-3 parts of lauromacrogol;

0.1 to 1.5 portions of climbazole.

The shampoo also comprises the following components in parts by weight:

100.1 to 2.5 portions of polyquaternium;

15-30 parts of sodium laureth sulfate;

coco glucoside and glyceryl oleate 3-8 parts.

The shampoo also comprises the following components in parts by weight:

0.1 to 1.5 portions of DMDM hydantoin;

1-3 parts of sodium dilinoleidopropyl PG-dimethyl ammonium chloride phosphate;

0.1 to 1.5 portions of EDTA-disodium;

0.1 to 0.5 portion of ethylene glycol distearate;

1-5 parts of acrylic acid (ester) crosslinked polymer.

The shampoo also comprises the following components in parts by weight:

1-5 parts of potassium hydroxide;

1-5 parts of cocamidopropyl betaine.

The shampoo is prepared from 100 parts by weight of water at constant volume.

The preparation method of the lauromacrogol shampoo suitable for scalp care of patients with psoriasis is characterized by comprising the following steps:

the method comprises the following steps:

the method comprises the following steps: adding the phase A into an emulsifying pot, and uniformly stirring; the phase A comprises: water;

step two: adding the phase B into a main boiler, heating and uniformly stirring; the phase B comprises: polyquaternium-10, sodium laureth sulfate, coco glucoside, glyceryl oleate, EDTA-disodium, ethylene glycol distearate;

step three: dissolving phase C, adding into a main pot, stirring uniformly, heating, adding phase D, and stirring; the phase C comprises: acrylic crosslinked polymers; phase D comprises: potassium hydroxide;

step four: cooling, adding the phase E, and uniformly stirring; phase E comprises: panthenol;

step five: cooling, sequentially adding F, G, H, I, J phases, stirring uniformly, and discharging after the inspection is qualified; the phase F comprises: glycerol, DMDM hydantoin; G. h, I, J phases are: dilinoleidopropyl PG-dimethyl ammonium chloride sodium phosphate, lauromacrogol, climbazole and cocamidopropyl betaine.

In the second step, the temperature is raised to 80 ℃, and the mixture is dissolved and stirred uniformly.

In the third step, stirring is carried out for 20 minutes, the homogenizing rotation speed is 2800 revolutions per minute, and the temperature is increased to 75 ℃.

In step four, the mixture was cooled to 45 ℃ and stirred for 5 minutes.

And step five, cooling to 30 ℃, stirring for 5 minutes, and discharging.

The invention has the following advantages:

1. the shampoo disclosed by the invention can solve the daily skin care problem of patients with psoriasis, has the effects of moisturizing, repairing and relieving itching, particularly contains lauromacrogol in the formula, has a slight anesthetic effect, and can be used as an external skin care preparation to mildly clean skin, soften skin cutin and repair and maintain skin.

2. The formula of the invention particularly comprises sodium hyaluronate, the main effect is moisture retention, the invention belongs to a moisture retention factor with strongest moisture retention at present, and the sodium hyaluronate can repair skin injury, promote proliferation and differentiation of epidermal cells, clear oxygen free radicals, delay skin aging and remove wrinkles, so the sodium hyaluronate is widely applied to skin care products and medical cosmetic plastic at present.

Clinically used sodium hyaluronate is divided into macromolecules, middle molecules and small molecules, and the effect of the sodium hyaluronate is different according to different molecular weights. The macromolecular sodium hyaluronate has the function of crosslinking and is mainly used for playing the role of supporting filling, such as filling of nasolabial sulcus, filling of lacrimal sulcus and micro-plastic of the nose. Small-molecule sodium hyaluronate is often used for moisturizing, wrinkle resistance, aging resistance, skin quality improvement and skin glossiness improvement, for example, a clinically used water needle is mainly composed of sodium hyaluronate.

3. The formula of the invention particularly comprises glycerin, and the glycerin has strong water absorption. Can absorb moisture in the air to moisturize the skin, and can lock the moisture in the skin to prevent the moisture from losing. Glycerol can help skin heal, reduce the incidence of related dermatitis, and restore normal barrier function to the skin. In addition, glycerol absorbed into the intercellular layer may help the dermal lipids to perform better; glycerol also has a certain protective effect against external stimuli and can promote the self-repairing function of damaged cells.

Detailed Description

The present invention will be described in detail with reference to specific embodiments.

The invention relates to a polycinnamic alcohol shampoo suitable for skin care of patients with psoriasis, which comprises the following components in parts by weight:

0.1 to 1.5 portions of panthenol;

1-5 parts of glycerol;

1-3 parts of lauromacrogol;

0.1 to 1.5 portions of climbazole;

100.1 to 2.5 portions of polyquaternium;

15-30 parts of sodium laureth sulfate;

coco glucoside and glyceryl oleate 3-8 parts (mixed in equal amount);

0.1 to 1.5 portions of DMDM hydantoin;

1-3 parts of sodium dilinoleidopropyl PG-dimethyl ammonium chloride phosphate;

0.1 to 1.5 portions of EDTA-disodium;

0.1 to 0.5 portion of ethylene glycol distearate;

1-5 parts of acrylic acid (ester) crosslinked polymer;

1-5 parts of potassium hydroxide;

1-5 parts of cocamidopropyl betaine;

the shampoo is prepared from 100 parts by weight of water at constant volume.

The preparation method of the lauromacrogol shampoo suitable for nursing the scalp of a patient with psoriasis comprises the following steps:

the method comprises the following steps: adding the phase A into an emulsifying pot, and uniformly stirring; the phase A comprises: water;

step two: adding the phase B into a main boiler, heating and uniformly stirring; the phase B comprises: polyquaternium-10, sodium laureth sulfate, coco glucoside, glyceryl oleate, EDTA-disodium, ethylene glycol distearate;

step three: dissolving phase C, adding into a main pot, stirring uniformly, heating, adding phase D, and stirring; the phase C comprises: acrylic crosslinked polymers; phase D comprises: potassium hydroxide;

step four: cooling, adding the phase E, and uniformly stirring; phase E comprises: panthenol;

step five: cooling, sequentially adding F, G, H, I, J phases, stirring uniformly, and discharging after the inspection is qualified; the phase F comprises: glycerol, DMDM hydantoin; G. h, I, J phases are: dilinoleidopropyl PG-dimethyl ammonium chloride sodium phosphate, lauromacrogol, climbazole and cocamidopropyl betaine.

In the second step, the temperature is raised to 80 ℃, and the mixture is dissolved and stirred uniformly.

In the third step, stirring is carried out for 20 minutes, the homogenizing rotation speed is 2800 revolutions per minute, and the temperature is increased to 75 ℃.

In step four, the mixture was cooled to 45 ℃ and stirred for 5 minutes.

And step five, cooling to 30 ℃, stirring for 5 minutes, and discharging.

The shampoo formula provided by the invention comprises the following components:

1. the lauromacrogol is an ether compound, is also named as laureth-9, is ethoprosterol and polidocanol, is the hardening drug which is the most widely used in European and American countries at present in clinical application, is mainly applied to hardening treatment of varicosity, venous malformation, hemangioma, internal hemorrhoid, cystic diseases and the like, is introduced into Germany for the first time in 1936 to be used as an anesthetic, and in 1963, Henschel finds that intravascular injection of high-concentration lauromacrogol has a vascular wall stimulation effect, and carries out deep research on the lauromacrogol on the market, and reports the hardening treatment effect of the lauromacrogol for the first time. Polycinnamic alcohol was used as a hardener since 1967. In addition, the lauromacrogol also has a mild anesthetic effect, so the lauromacrogol serving as an external preparation not only can promote the rapid scabbing and healing of wounds, but also has the effects of quickly relieving itching, relieving pain and the like.

The orally taken rat LD50 of the lauromacrogol is 1000mg/kg, and the orally taken mouse LD50 of the lauromacrogol is 1170mg/kg, so the lauromacrogol has very small side effect and is often used in a cosmetic formula.

The application of the lauromacrogol in cosmetics is very wide, and the lauromacrogol is generally used as a nonionic surfactant for an oil-in-water emulsifier of cream cosmetics and shampoo cosmetics and can also be used as a detergent of the shampoo cosmetics. Has excellent emulsifying, dispersing, foaming, cleaning and washing performances and unique wetting performance.

The panthenol and vitamin B6 absorbed by skin can increase hyaluronic acid content in skin, and promote metabolism of protein, saccharide and fat. The panthenol has small molecular weight, so the panthenol can effectively permeate into the horny layer, moistens the horny layer on the surface of the skin and plays a role in effectively moisturizing. Panthenol is effective in improving rough skin and softening skin. The panthenol can enter hair, and has effects of improving hair luster, reducing hair bifurcation, repairing damaged hair, and keeping moisture of hair.

Climbazole has broad-spectrum bactericidal property, has effects of relieving itching and removing dandruff, and can be used in conditioning shampoo, hair care shampoo, antibacterial soap, bath lotion, medicated toothpaste, mouthwash, etc.

The water absorption of the glycerol is strong. Can absorb moisture in the air to moisturize the skin, and can lock the moisture in the skin to prevent the moisture from losing. Glycerol can help skin heal, reduce the incidence of related dermatitis, and restore normal barrier function to the skin. In addition, glycerol absorbed into the intercellular layer may help the dermal lipids to perform better; glycerol also has a certain protective effect against external stimuli and can promote the self-repairing function of damaged cells.

Example 1:

example 2:

experience 1: after a certain horse is aged 28 years old and the scalp is dry, has no dandruff and is itchy, the scalp is daily nursed by the poly-cinnamic alcohol shampoo disclosed by the embodiment 1 of the invention, allergic stimulation reaction is avoided, the dry scalp and the scalp pruritus are relieved, and the scalp condition is good.

Case 2: when a certain woman in 31 years old has dry and itchy scalp, the scalp is daily nursed by the poly-cinnamic alcohol shampoo disclosed by the embodiment 1 of the invention, and the scalp itching disappears after one week by combining drug treatment, so that the problem of dandruff falling is greatly improved within 2 months after the poly-cinnamic alcohol shampoo is continuously used for daily nursing.

Case 3: people who are 53 years old, have dry, itchy and dandruff-removing scalp, the lauromacrogol shampoo disclosed by the invention is used for daily scalp care, and combined with drug treatment, allergic stimulation reaction is avoided, the dry scalp and scalp itching conditions are relieved, and the scalp condition is good.

Case 4: after a certain woman is aged 37 years old and the scalp is dry, itchy and dandruff-removing, the situation that the scalp is dried and itchy is obviously relieved when the lauromacrogol shampoo disclosed by the invention is used for daily scalp nursing, the scalp state is good within 6 months, and the scalp state is greatly improved compared with the original scalp state.

Case 5: for a certain woman in age of 45, scalp allergy and scalp itching occur, the lauromacrogol shampoo disclosed by the invention is used for daily scalp care, the allergy is relieved within two days, and the scalp returns to normal.

Case 6: when a certain welfare is male and is 25 years old, the scalp is dry, itchy and dandruff-removing, the scalp is nursed daily by using the lauromacrogol shampoo disclosed by the invention example 2, the dry scalp and the itching condition of the scalp are obviously relieved, the scalp state is good within 6 months, and the scalp does not relapse.

The continuous tracking of the use of the product of the invention for six months by 53 psoriasis patients was tested in terms of the absorption, mildness, dryness relief, itching relief, no irritative and allergic symptoms of the product, etc. And (3) result feedback: 95% of the test subjects felt better absorbency, 97% felt milder product and better tolerance, 94% felt dry-off, the skin moisturized for a longer time, 96% felt itching relieved and 96% not irritated and allergic symptoms.

The invention is not limited to the examples, and any equivalent changes to the technical solution of the invention by a person skilled in the art after reading the description of the invention are covered by the claims of the invention.