阅读说明：本技术 一种用于治疗黑眼圈的组合物和发热眼罩 (Composition for treating dark circles and heating eye patch ) 是由 郭静 庞尧斌 赵谊佳 姚业静 雷静 于 2021-07-27 设计创作，主要内容包括：本发明中医药领域,具体涉及一种用于治疗黑眼圈的组合物和发热眼罩。本发明提供一种用于预防和/或治疗黑眼圈的组合物,它包括如下重量份的组份：薏苡仁10-14份；珍珠4-8份；诃子8-12份；白及6-10份；芦荟10-14份；白芷2-6份。本发明还提供上述组合物的提取物以及它们制成的药物。本发明的发热眼罩中装入有上述组合物、提取物或药物。本发明的技术方案对黑眼圈的预防和/或治疗效果好,具有很好的应用前景。(The invention belongs to the field of medicines, and particularly relates to a composition for treating dark circles and a heating eye patch. The invention provides a composition for preventing and/or treating dark circles, which comprises the following components in parts by weight: 10-14 parts of coix seeds; 4-8 parts of pearl; 8-12 parts of myrobalan; 6-10 parts of bletilla striata; 10-14 parts of aloe; 2-6 parts of radix angelicae. The invention also provides the extract of the composition and a medicament prepared from the extract. The heating eye patch of the invention is filled with the composition, the extract or the medicine. The technical scheme of the invention has good effect of preventing and/or treating the dark circles and has good application prospect.)

1. The composition or the extract thereof for preventing and/or treating the dark eye circles is characterized by comprising the following components in parts by weight:

10-14 parts of coix seeds;

4-8 parts of pearl;

8-12 parts of myrobalan;

6-10 parts of bletilla striata;

10-14 parts of aloe;

2-6 parts of radix angelicae.

2. The composition or extract thereof according to claim 1, wherein the composition is composed of the following components in parts by weight:

12 parts of coix seeds;

6 parts of pearl;

10 parts of myrobalan;

8 parts of bletilla striata;

12 parts of aloe;

4 parts of radix angelicae.

3. The composition or extract thereof according to claim 1, wherein the extract is obtained by extracting the composition with a solvent.

4. A composition or extract thereof according to claim 3, wherein: the solvent is water.

5. A medicament for preventing and/or treating dark under-eye circles, characterized in that: the composition is prepared by taking the composition or the extract thereof as an active ingredient according to any one of claims 1 to 4 and adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients.

6. The medicament of claim 5, wherein: it is a hot compress external application medicine.

7. Use of the composition of any one of claims 1 to 4 or an extract thereof for the manufacture of a medicament for the prevention and/or treatment of dark under-eye circles.

8. A traditional Chinese medicine fever eye patch for preventing and/or treating dark circles is characterized in that: the eyeshade comprises an eyeshade body (5), wherein the eyeshade body (5) is provided with a structure for charging medicine;

the structure for charging is loaded with: a composition or extract thereof according to any one of claims 1 to 4, or a medicament according to claim 5 or 6.

9. The eye shield of claim 8, wherein: the structure for charging comprises a medicine bag interlayer (8), the medicine bag interlayer (8) comprises a medicine bag inner interlayer (3) and a medicine bag outer interlayer (4), the medicine bag inner interlayer (3) is used for filling the composition or the medicine, and the medicine bag outer interlayer (4) is used for filling a heating medium.

10. The eye shield of claim 8 or 9, wherein: the structure for containing a medicine is filled with the composition, the extract or the medicine in an amount of 6-10 g.

Technical Field

The invention belongs to the field of medicines, and particularly relates to a composition for treating dark circles and a heating eye patch.

Background

The black eye circles are formed by the fact that blood flow speed of blood vessels of skin at eyes is too slow to form stagnant flow due to night stay, large emotion fluctuation, eye fatigue and aging; or insufficient oxygen supply to the tissues, excessive accumulation of metabolic waste in blood vessels, and pigmentation of the eye. The older the person, the thinner the subcutaneous fat around the eye becomes, so the more visible the dark circles. The black eye includes the following types: one is the cyan and black eye circle, which is the blood retention of the microvasculature; the other is dark brown eye, and is deficient in melanin production or metabolism. The dark and green eyes are often seen in people with irregular work and rest, and are often seen in young people. The black eye circles of tea are often related to the aging, and the long-term solarization and the like cause pigment deposition around the eyes to form black eye circles over time.

There are various reasons for the dark circles, including: 1. genetic constitution and physiological structure: the skin around part of human eye orbit is extremely thin, the subcutaneous tissue is extremely few, and when blood flows through the great veins, blue-black areola can conveniently appear under the skin surface layer, and black eye circles are shown; 2. insufficient sleep: when the eyelids cannot rest due to staying up overnight, the capillaries continuously contract and increase blood flow for a long time, blood vessels of subcutaneous tissues of the eye circles are stagnated and edema, and dark shadows are remained. 3. Weak body after long-term illness or early recovery from a big illness: due to the weak subcutaneous tissue around the eye, pigmentation easily occurs, and a layer of black circles appears on the upper and lower eyelids. 4. Inflammation: atopic allergy or allergic contact dermatitis can involve dark circles around the eye sockets. 5. And others: cosmetic overuse, smoking, aging, irregular menstruation, late pregnancy, excessive sexual intercourse, and certain liver and kidney diseases may cause dark circles.

At present, the main treatment means of the black eye can be divided into non-invasive and invasive treatment methods. Wherein the non-invasive treatment method comprises using covering agent or cosmetics, external medicine, chemical skin replacement and some non-invasive laser treatment; invasive treatment methods often include soft tissue augmentation, sclerosant injection and other surgical procedures. These methods are costly and difficult for most patients to adhere to.

The Chinese invention patent application 'CN201410684984. X preparation method of eye patch for eliminating black eye circles' provides an eye patch for eliminating black eye circles, which is prepared from the following raw materials: 20-30 parts of angelica, 15-20 parts of motherwort, 20-30 parts of cassia seed, 20-30 parts of astragalus, 20-30 parts of coix seed, 10-15 parts of salvia miltiorrhiza, 5-10 parts of safflower, 5-10 parts of peach seed, 5-10 parts of white poria, 5-10 parts of angelica dahurica and 15-20 parts of pearl powder. The black eye patch is applied to eyelids, and has the advantages of simple and convenient application, no wound and low cost. However, the therapeutic effect of the black eye patch is still unsatisfactory, and thus there is a need to develop new and more effective drugs to provide more options for treating black eyes.

Disclosure of Invention

In view of the problems of the prior art, the present invention provides a composition for treating dark circles and a heat-generating eye patch, which aims to: provides a novel composition for treating black eye circles and improves the treatment effect of the black eye circles.

A composition or extract thereof for preventing and/or treating dark circles under the eyes, wherein the composition comprises the following components in parts by weight:

10-14 parts of coix seeds;

4-8 parts of pearl;

8-12 parts of myrobalan;

6-10 parts of bletilla striata;

10-14 parts of aloe;

2-6 parts of radix angelicae.

Preferably, the composition consists of the following components in parts by weight:

12 parts of coix seeds;

6 parts of pearl;

10 parts of myrobalan;

8 parts of bletilla striata;

12 parts of aloe;

4 parts of radix angelicae.

Preferably, the extract is obtained by extracting the above composition with a solvent.

Preferably, the solvent is water.

The invention also provides a medicament for preventing and/or treating dark circles, which is prepared by taking any one of the composition and the extract as an active ingredient and adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients.

Preferably, it is a topical hot compress.

The invention also provides application of any one of the composition and the extract in preparing a medicament for preventing and/or treating black eye circles.

The invention also provides a traditional Chinese medicine heating eye patch for preventing and/or treating black eye circles, which comprises an eye patch body, wherein the eye patch body is provided with a structure for charging medicine;

the structure for charging is loaded with: the above composition, extract or medicament.

The invention also provides the structure for charging, which comprises a medicine bag interlayer, wherein the medicine bag interlayer comprises a medicine bag inner interlayer and a medicine bag outer interlayer, the medicine bag inner interlayer is used for filling the composition or the medicine, and the medicine bag outer interlayer is used for filling the heating medium.

Preferably, the structure for containing a medicament is filled with the composition, extract or drug in an amount of 6-10 g.

The traditional Chinese medicine formula provided by the invention comprises six medicines: coix seed, pearl, aloe, bletilla, myrobalan and angelica dahurica. The six medicines are recorded in Chinese pharmacopoeia.

Coix seed: induce diuresis and drain dampness, invigorate spleen to arrest diarrhea, remove arthralgia, expel pus, remove toxicity and dissipate nodulation. Can be used for treating edema, loempe, dysuria, spleen deficiency, diarrhea, damp arthralgia, spasm, pulmonary abscess, intestinal abscess, wart, and cancer.

Pearl: tranquilization and arresting convulsion, improving eyesight and removing nebula, detoxifying and promoting granulation, moistening skin and removing spots. Can be used for treating pavor, insomnia, infantile convulsion, epilepsy, conjunctival congestion, nebula, unhealing sore and ulcer, and skin mottle.

Aloe vera: purgation, purging liver-fire, killing parasites and curing malnutrition. Can be used for treating constipation due to heat accumulation, infantile malnutrition, and convulsive epilepsy; it is used externally to treat tinea and sore.

And (3) common bletilla pseudobulb: astringe to stop bleeding, resolve swelling and promote tissue regeneration. Can be used for treating hemoptysis, hematemesis, traumatic hemorrhage, pyocutaneous disease, toxic swelling, and chapped skin.

Myrobalan fruit: astringe intestines to check diarrhea, astringe lung to stop cough, lower fire and relieve sore throat. Can be used for treating chronic diarrhea, dysentery, proctoptosis due to hematochezia, cough and asthma due to lung deficiency, chronic cough, pharyngalgia, and hoarseness.

Radix angelicae: relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, and relieving swelling, and can be used for treating common cold, headache, supercilium pain, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, toothache, leukorrhagia, and pyocutaneous disease with swelling and pain.

The formula strictly follows the compatibility principle of the traditional Chinese medicine prescription and is reasonable, and the formula is as follows: in the formula, aloe is a monarch drug, has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, dredging channels and collaterals around eyes, and preventing new blood from generating; the coix seed has the effects of tonifying spleen, removing dampness, inducing diuresis to alleviate edema, inducing diuresis to alleviate stasis, and the myrobalan has the effects of astringing and arresting discharge, preventing healthy energy consumption, dispelling wind by angelica dahurica, eliminating dampness, relieving swelling and pain, is used as a ministerial drug, and the pearl has the effects of clearing heat, nourishing yin, improving eyesight, detoxifying, promoting blood circulation by rhizoma bletillae and removing blood stasis and is used as an adjuvant drug for assisting the monarch drug. The whole formula has a rigorous compatible type, the medicines are precise and appropriate, and the effects of clearing heat and promoting diuresis, promoting blood circulation and removing blood stasis, and whitening and removing freckles are achieved together.

The traditional Chinese medicines in the traditional Chinese medicine coating layer provided by the invention act synergistically under the compatibility principle of the traditional Chinese medicine theory and prescriptions, and achieve the effects of relieving dark eye circles and reducing pigmentation. The invention has the following beneficial effects:

1. provides a new traditional Chinese medicine formula, and has good prevention and treatment effects on dark circles when the traditional Chinese medicine formula is used as an external application medicine in thermal therapy.

2. The traditional Chinese medicine heating eye patch provided by the invention is convenient and quick to use, enables the medicine to directly reach the focus through thermal therapy and external application, is simple and convenient to take effect, and is relatively easy to accept in price.

3. The traditional Chinese medicine provided by the invention is composed of clinical common Chinese herbal medicines recorded in 'Chinese pharmacopoeia' (first edition) of 2015 edition, is nontoxic and can be safely used.

Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.

The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.

Drawings

FIG. 1 is a front view of the traditional Chinese medicine fever eye patch of example 1;

FIG. 2 is a rear view of the traditional Chinese medicine fever eye patch of example 1;

FIG. 3 is a schematic structural view of the sandwich layer of the drug pack in example 1;

FIG. 4 shows tyrosinase inhibition rates of the respective experimental groups in Experimental example 1.

Wherein, 1-magic plaster, 2-connecting line, 3-medicine bag inner interlayer, 4-medicine bag outer interlayer, 5-eyeshade body, 6-treatment area, 7-medicine bag layer, 8-medicine bag interlayer, 9-inner and outer junction, 10-outer layer, 11-inner layer, and 12-opening.

Detailed Description

Example 1

The present embodiment provides a traditional Chinese medicine fever eye patch, as shown in fig. 1-3, which has the following structure:

including eye-shade body 5, eye-shade body 5 both ends are connected with connecting wire 2, set up magic subsides 1 on the connecting wire 2 in order to make things convenient for wearing of eye-shade. The eyecup body 5 includes an outer layer 10 and an inner layer 11. The edges of the outer layer 10 and the inner layer 11 are provided with inner and outer joints 9, and the upper part is provided with an opening 12, thereby forming a bag shape. A medicine coating layer 7 is arranged between the outer layer 10 and the inner layer 11, and the medicine coating layer 7 can be taken out and replaced, thereby realizing the reutilization of the eyepatch. The drug bag layer 7 is provided with a drug bag interlayer 8, and the drug bag interlayer 8 comprises a drug bag outer interlayer 4 and a drug bag inner interlayer 3. The outer interlayer 4 of the medicine bag is close to the outer layer 10 and is used for filling a heating medium, and the heating medium can be an iron powder heating device or a carbon powder bag (both can be used as heating media). The interlayer 3 of the medicine bag is close to the layer 11 and is used for filling medicines for treating black eye circles. The position on the inner layer 11 corresponding to the medicine bag interlayer 8 is a treatment area 6, and the treatment area is attached to the lower eyelid when in treatment. The inner layer 11 is made of acupuncture cotton, so that the heat insulation with the skin is achieved, the friction damage is reduced, and the effect of uniformly exerting the drug effect is guaranteed.

In this embodiment, the medicine for treating dark circles consists of the following components: 12g of coix seeds, 6g of pearls, 10g of myrobalan, 8g of rhizoma bletillae, 12g of aloe and 4g of angelica dahurica. The medicines are ground and screened by No. 5 of 'Chinese pharmacopoeia' (one part) of 2015 edition to obtain powder, and the powder is filled into an interlayer 3 in a medicine bag.

The using method of the embodiment is as follows:

the medicine bag layer 7 is sealed and stored, and when in use, the medicine bag layer is taken out from the sealed package and is placed into the eyeshade body 5, and the medicine in the interlayer 3 in the medicine bag transfers the efficacy of volatile components in the formula to eyes through heat generated by a heating medium. When the volatile smell of the medicine package is weakened and the temperature is reduced, the medicine package layer 7 is replaced. A new medicine coating layer 7 is taken for thermal therapy and external application each time, and the wearing time is not less than 30 minutes each time.

Example 2

This example is substantially the same as example 1, except that: the medicine for treating the dark eye circles is obtained by preparing the following components into an aqueous extract: 12g of coix seeds, 6g of pearls, 10g of myrobalan, 8g of rhizoma bletillae, 12g of aloe and 4g of angelica dahurica.

Experimental example 1 clinical observation experiment for treating dark circles under the eyes

General data

Patient gender and age range: 130 patients aged 15-60 years, 70 women and 60 men all had black eyes of different degrees. The clinical doctor evaluates that the eye mask has obvious pigmentary black eye circles, including simple pigmentary black eye circles and mixed type black eye circles mainly comprising pigmentary black eye circles, and VISIA facial skin imager is adopted to detect the visible obvious pigmentation of the upper eyelid and the lower eyelid.

(II) Black eye administration method

The traditional Chinese medicine fever eye patch of example 1 was dispensed.

(III) therapeutic efficacy judgment criteria

Mechanical measurement: the skin was examined for erythema and melanin index using a Mexameter MX18(Courage and Khazaka, Germany). The patient's lower eyelid near the center point was selected to measure E and N values by Mexameter MX18 successively 5 times, and the average value was obtained.

Self-evaluation: self-scoring is carried out by the doctor aiming at the self black eye improvement condition from the color depth, the black eye range and the overall improvement satisfaction degree, and the scoring range is 0-10 min:

no improvement on 0 point;

1-4 are slightly improved;

5-7 for moderate improvement;

the improvement is obvious in 8-10 points.

(IV) evaluation of tolerance and adverse reaction

At follow-up visit the product was asked if discomfort occurred after use and recorded, such as: erythema, swelling, stinging, itching, burning, exudation, etc. The evaluation value is 0-3 points. 0 is absent, 1 is mild, 2 is moderate, and 3 is severe.

(V) treatment outcome

And (3) judging the curative effect: the results are as follows

TABLE 1130 patients after treatment

Therapeutic results	Number of cases (example)	Effective rate (%)
			Obviously improve	28	21.5
Improvement in moderate degree	42	32.3
			Slightly improved	36	27.7
Without improvement	24	-
			Total of	130	81.5

Adverse reactions: adverse reactions are not seen during the administration period, and the skin redness at the later period of treatment of part of patients is occasionally seen.

Experimental example 2 typical cases

Typical case 1:

zhangyi, women, who stay overnight, cause severe dark circles and discomfort such as dryness and fever of eyes, and after the eye patch manufactured in example 1 is applied every night, the dark circles fade away gradually, symptoms such as dryness and fever of eyes are improved, and the normal skin color is basically recovered after the eyes stay for about 5 weeks.

Typical case 2:

ruan is, men stay on duty for a long time, and black eyes are aggravated with eye bags, symptoms such as soreness of waist, backache, weakness of limbs and the like are often caused, eyes are dry, and skin is dry and desquamation is often caused. The eye patch made in example 1 was applied every night, and with regular rest, sleep was increased and dark circles subsided around 2 weeks.

EXAMPLE 3 tyrosinase inhibition assay

1. Experimental methods

1.1 extracting the whitening components of the traditional Chinese medicine: extracting effective whitening components from coix seeds, pearls, bletilla striata, myrobalan, aloes and angelica dahurica according to a water reflux method.

The specific method comprises collecting 5g of Chinese medicinal materials, adding 12 times of distilled water, soaking at room temperature for 0.5h, heating under reflux for 2h, filtering, collecting filtrate, centrifuging at 10000r/min for 10min, collecting supernatant, concentrating under reduced pressure, and vacuum drying to obtain water extract.

1.2 preparation of the solution

Preparation of tyrosinase solution comprises weighing peeled and cut rhizoma Solani Tuber osi 20g, adding phosphate buffer (pH6.8)20mL at a ratio of 1:1(m/v), homogenizing at high speed for 1min, centrifuging at 3000r/min for 15min, and decanting the supernatant. The supernatant (10 mL) was pipetted into a brown bottle (25 mL) and added with PBS (pH6.8) to the volume, and the solution was kept in ice water bath for use and used up within 2 h.

The preparation of sample solution comprises extracting the above 6 Chinese medicinal materials with water with PBS (pH6.8) to obtain 10mg/mL solutions, and filtering.

1.3 determination of tyrosinase Activity inhibition

Before measurement, precisely transferring an A1 test sample of 2mL PBS and 1mL L-tyrosine solution; a2 test sample, 3mL PBS solution; a3 test sample, 1mL L-tyrosine solution +1mL PBS solution; a4 test sample was 2mL PBS solution, and each group was run in parallel at 3 copies. Preserving the temperature in a 37 ℃ water bath for 10min, immediately adding 1mL of potato tyrosinase solution, respectively, adding 1mL of sample solution into A3 and A4, respectively

Mixing, reacting in water bath at 37 deg.C for 2min, measuring absorbance at 475nm, and recording data.

TABLE 1 reaction solution composition (unit: mL)

Tyrosinase activity inhibition rate I (%) [ (a 1-a 2) - (A3-a 4) ]/(a 1-a 2) prepared from

100 percent. A1 is enzyme-added mixture without Chinese medicinal materials; a2 is the mixture of Chinese medicinal materials and enzyme; a3 is the mixture of Chinese medicinal materials and enzyme; a4 adding Chinese medicinal materials and enzyme.

2. Results of the experiment

The results of measuring the tyrosinase activity inhibition rate of 6 kinds of medicinal materials alone are shown in the following table.

TABLE 2 determination of the inhibition ratio of Chinese medicinal extracts on tyrosinase activity (I%)

Name of the drug	Inhibition rate of water extraction
		Coix seed	60
Pearl and its preparation method	30
		Rhizoma bletillae	40
Aloe vera	70
		Root of Dahurian Angelica	20
Medicine terminalia fruit	51

Wherein, the water extracts of aloe, coix seed and myrobalan have stronger inhibiting effect on the activity of tyrosinase.

The inhibition effect of the drug formulas with different proportions on the tyrosinase activity is tested, wherein each experimental group solution is obtained by mixing 6 sample solutions with different proportions, and the mixing proportion is shown in table 2.

TABLE 2 medicine proportioning, concentration and proportioning table (g/L)

Name of the drug	Coix seed	Pearl and its preparation method	Medicine terminalia fruit	Rhizoma bletillae	Aloe vera	Root of Dahurian Angelica
							Experimental group 1	0.76	2.30	1.15	1.95	1.54	2.30
Experimental group 2	2.30	1.15	1.95	1.54	2.30	0.76
							Experimental group 3	1.15	1.95	1.54	2.30	0.76	2.30
Experimental group 4	1.95	1.54	2.30	0.76	2.30	1.15
							Experimental group 5	1.54	2.30	0.76	2.30	1.15	1.95
Experimental group 6	2.30	0.76	2.30	1.15	1.95	1.54

The tyrosinase inhibition results for each experimental group are shown in fig. 4. Tyrosinase is an oxidase and is the rate-limiting enzyme in the regulation of melanin production. The black eye is generated due to melanin generation or metabolism insufficiency, pigmentation is caused around the eyes along with age, long-term solarization and the like, and the black eye is formed in a long-term way, so that the tyrosinase is important for the generation of the black eye. As can be seen from the figure, the formula of the experimental group 2 has the tyrosinase inhibition rate of 80 percent, and the inhibition rate is higher than that of any one of the 6 raw medicinal materials when the raw medicinal materials are used independently. From the above experimental results, it can be concluded that the formulation of experimental group 2 (corresponding to the drug ratio of example 1) has the best black eye prevention and treatment effects.

The composition and the heating eye patch provided by the invention have good prevention and treatment effects on black eyes and good application prospects.