阅读说明：本技术 用于肽纯化的无痕还原性可裂解接头分子 (Traceless reductively cleavable linker molecules for peptide purification ) 是由 罗伯特·齐特巴特 奥利弗·赖曼 于 2019-08-27 设计创作，主要内容包括：本发明涉及式(1)：X-T-b-V-a-U-Y-Z(1)的接头分子以及使用所述接头分子纯化肽的方法。接头分子可以经由部分X偶联至纯化树脂并且在释放离去基团Z下经由部分Y偶联至肽。T是任选的间隔基部分并且V是任选的吸电子部分。U是结合至至少一个吸电子部分V、W或E的芳基或5元或6元杂芳基部分。接头在酸性条件下是稳定的并且经添加还原剂释放肽。(The invention relates to a compound of formula (1): X-T b ‑V a -U-Y-Z (1) and a method for purifying a peptide using said linker molecule. The linker molecule may be coupled to the purification resin via moiety X and to the peptide via moiety Y upon release of the leaving group Z. T is an optional spacer moiety and V is an optional electron withdrawing moiety. U is bound to at least oneAn aryl or 5-or 6-membered heteroaryl moiety of the electron-withdrawing moiety V, W or E. The linker is stable under acidic conditions and releases the peptide upon addition of a reducing agent.)