阅读说明：本技术 一种针对口腔溃疡的牙膏 (Toothpaste for dental ulcer ) 是由 陈万金 蔡丽萍 黄强 于 2019-10-12 设计创作，主要内容包括：本发明公开了一种针对口腔溃疡的牙膏,牙膏中成分按照重量配比为：摩擦剂20-40％、山梨糖醇30-60％、表面活性剂2.0-3.0％、薄荷脑0.1-0.3％、薁磺酸钠0.01-1.0％、甘草酸二钾0.2-1.0％、增稠剂0.8-1.3％、蔗糖素0.1-0.4％、食品级香精0.8-2.0％、忍冬花提取物0.5-1.0％、纯净水余量。该针对口腔溃疡的牙膏以薁磺酸钠为关键功效成分,薁磺酸钠,安全无毒,对变异链球菌、金黄色葡萄球菌、白色念珠菌、大肠杆菌的杀灭率达到99.98％以上,对牙龈卟啉单胞菌的杀灭率达到98.14％以上,并具有抑制牙菌斑、减轻牙龈炎、促进复发性口腔溃疡愈合的显著效果。(The invention discloses toothpaste for dental ulcer, which comprises the following components in parts by weight: 20-40% of a rubbing agent, 30-60% of sorbitol, 2.0-3.0% of a surfactant, 0.1-0.3% of menthol, 0.01-1.0% of sodium azulene sulfonate, 0.2-1.0% of dipotassium glycyrrhizinate, 0.8-1.3% of a thickening agent, 0.1-0.4% of sucralose, 0.8-2.0% of food grade essence, 0.5-1.0% of honeysuckle flower extract and the balance of purified water. The toothpaste for dental ulcer takes sodium azulene sulfonate as a key functional component, the sodium azulene sulfonate is safe and non-toxic, the killing rate on streptococcus mutans, staphylococcus aureus, candida albicans and escherichia coli reaches more than 99.98%, the killing rate on porphyromonas gingivalis reaches more than 98.14%, and the toothpaste has the remarkable effects of inhibiting dental plaque, relieving gingivitis and promoting healing of recurrent oral ulcer.)

1. A toothpaste against canker sores, characterized by: the toothpaste comprises two components of sodium azulene sulfonate and dipotassium glycyrrhizinate, and the two components are mixed in the toothpaste according to the weight ratio: 0.01 to 1.0 percent of sodium azulene sulfonate and 0.2 to 1.0 percent of dipotassium glycyrrhizinate.

2. The toothpaste for dental ulcer according to claim 1, wherein: the toothpaste comprises the following components in parts by weight: 20-40% of a rubbing agent, 30-60% of sorbitol, 2.0-3.0% of a surfactant, 0.1-0.3% of menthol, 0.01-1.0% of sodium azulene sulfonate, 0.2-1.0% of dipotassium glycyrrhizinate, 0.8-1.3% of a thickening agent, 0.1-0.4% of sucralose, 0.8-2.0% of food grade essence, 0.5-1.0% of honeysuckle flower extract and the balance of purified water.

3. The toothpaste for dental ulcer according to claim 2, wherein: 34% of an abrasive, 46% of sorbitol, 2.0% of a surfactant, 0.2% of menthol, 0.2% of sodium azulene sulfonate, 0.3% of dipotassium glycyrrhizinate, 1% of a thickening agent, 0.2% of sucralose, 1.2% of food-grade essence, 0.6% of a honeysuckle flower extract and 14.3% of purified water.

4. The toothpaste for dental ulcer according to claim 2, wherein: the toothpaste comprises the following components in parts by weight: 34% of an abrasive, 46% of sorbitol, 2.4% of a surfactant, 0.2% of menthol, 0.6% of sodium azulene sulfonate, 0.6% of dipotassium glycyrrhizinate, 1% of a thickening agent, 0.2% of sucralose, 1.4% of food-grade essence, 0.7% of a honeysuckle flower extract and 12.9% of purified water.

5. The toothpaste for dental ulcer according to claim 2, wherein: the toothpaste comprises the following components in parts by weight: 34% of an abrasive, 46% of sorbitol, 2.8% of a surfactant, 0.3% of menthol, 0.9% of sodium azulene sulfonate, 0.9% of dipotassium glycyrrhizinate, 1.2% of a thickening agent, 0.3% of sucralose, 1.6% of food grade essence, 0.8% of a honeysuckle flower extract and 11.2% of purified water.

6. The toothpaste for dental ulcer according to claim 2, wherein: the purified water is deionized water, the total number of bacteria is less than or equal to 80/g, and the conductivity is less than or equal to 15 mu s/cm.

Technical Field

The invention relates to the technical field of toothpaste research, in particular to toothpaste for dental ulcer.

Background

Recurrent oral ulcer, also called recurrent aphtha, recurrent aphthous stomatitis and recurrent aphtha, is the highest incidence of oral mucosa diseases, common cold, dyspepsia, mental stress, depression and the like can all occasionally cause the diseases, the diseases are better developed at lips, cheeks, tongue margin and the like, the diseases can all appear at any part of mucosa, the onset age is generally between 10 and 30 years old, and most women can all occur all the year round. The recurrent oral ulcer is self-limiting and can be self-healed in about 10 days. The incidence rate of the wound healing ointment in normal people is 10% -30%, no specific radical treatment method exists at present, and the clinical treatment mainly aims at promoting local wound healing.

Clinical treatment of recurrent oral ulcer mainly takes the modes of diminishing inflammation, relieving pain, preventing corrosion, promoting wound healing and the like. Many studies have evaluated the symptomatic treatment of various topical applications. During the ulcer attack, it is important to keep the oral cavity clean, related medicinal ingredients are added into the toothpaste to develop the special toothpaste for the oral ulcer, the toothpaste is used for brushing teeth twice every day, and the toothpaste is smeared on the ulcer part when the ulcer part is serious, so that the average ulcer period of a patient is shortened, and the pain index is reduced.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides toothpaste aiming at dental ulcer, which solves the problem that the existing dental ulcer can not be cured radically with special effect, and the toothpaste has the effects of inhibiting dental plaque, relieving gingivitis and promoting healing of recurrent oral ulcer.

In order to achieve the purpose, the invention provides the following technical scheme: the toothpaste for dental ulcer comprises sodium azulene sulfonate and dipotassium glycyrrhizinate, and the two components are prepared from the following raw materials in parts by weight: 0.01 to 1.0 percent of sodium azulene sulfonate and 0.2 to 1.0 percent of dipotassium glycyrrhizinate.

Preferably, the toothpaste comprises the following components in parts by weight: 20-40% of a rubbing agent, 30-60% of sorbitol, 2.0-3.0% of a surfactant, 0.1-0.3% of menthol, 0.01-1.0% of sodium azulene sulfonate, 0.2-1.0% of dipotassium glycyrrhizinate, 0.8-1.3% of a thickening agent, 0.1-0.4% of sucralose, 0.8-2.0% of food grade essence, 0.5-1.0% of honeysuckle flower extract and the balance of purified water.

Preferably, the abrasive agent is 34%, sorbitol 46%, surfactant 2.0%, menthol 0.2%, sodium azulene sulfonate 0.2%, dipotassium glycyrrhizinate 0.3%, thickening agent 1%, sucralose 0.2%, food grade essence 1.2%, honeysuckle flower extract 0.6%, and purified water 14.3%.

Preferably, the toothpaste comprises the following components in parts by weight: 34% of an abrasive, 46% of sorbitol, 2.4% of a surfactant, 0.2% of menthol, 0.6% of sodium azulene sulfonate, 0.6% of dipotassium glycyrrhizinate, 1% of a thickening agent, 0.2% of sucralose, 1.4% of food-grade essence, 0.7% of a honeysuckle flower extract and 12.9% of purified water.

Preferably, the toothpaste comprises the following components in parts by weight: 34% of an abrasive, 46% of sorbitol, 2.8% of a surfactant, 0.3% of menthol, 0.9% of sodium azulene sulfonate, 0.9% of dipotassium glycyrrhizinate, 1.2% of a thickening agent, 0.3% of sucralose, 1.6% of food grade essence, 0.8% of a honeysuckle flower extract and 11.2% of purified water.

Preferably, the purified water is deionized water, the total number of bacteria is less than or equal to 80/g, and the conductivity is less than or equal to 15 mu s/cm.

The beneficial effects are as follows:

the toothpaste for dental ulcer takes sodium azulene sulfonate as a key functional component, the sodium azulene sulfonate is safe and non-toxic, the killing rate on streptococcus mutans, staphylococcus aureus, candida albicans and escherichia coli reaches more than 99.98%, the killing rate on porphyromonas gingivalis reaches more than 98.14%, and the toothpaste has the remarkable effects of inhibiting dental plaque, relieving gingivitis and promoting healing of recurrent oral ulcer.

Detailed Description

All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The first embodiment is as follows:

a toothpaste for dental ulcer, the abrasive agent is 34%, sorbitol 46%, surfactant 2.0%, menthol 0.2%, sodium azulene sulfonate 0.2%, dipotassium glycyrrhizinate 0.3%, thickener 1%, sucralose 0.2%, food grade essence 1.2%, honeysuckle flower extract 0.6%, and purified water 14.3%;

example two:

the toothpaste for dental ulcer comprises the following components in parts by weight: 34% of an abrasive, 46% of sorbitol, 2.4% of a surfactant, 0.2% of menthol, 0.6% of sodium azulene sulfonate, 0.6% of dipotassium glycyrrhizinate, 1% of a thickening agent, 0.2% of sucralose, 1.4% of food-grade essence, 0.7% of a honeysuckle flower extract and 12.9% of purified water;

example three:

the toothpaste for dental ulcer comprises the following components in parts by weight: 34% of an abrasive, 46% of sorbitol, 2.8% of a surfactant, 0.3% of menthol, 0.9% of sodium azulene sulfonate, 0.9% of dipotassium glycyrrhizinate, 1.2% of a thickening agent, 0.3% of sucralose, 1.6% of food grade essence, 0.8% of a honeysuckle flower extract and 11.2% of purified water.

The toothpaste of the above embodiment is used for checking the use condition of the toothpaste with different proportions, each embodiment is checked in batches, the number of the checked persons in each embodiment is 20 patients suffering from the dental ulcer, and the use time is three days;

the effective calculation result is that the effect is not obvious + the effect is obvious + the cure can be completely realized;

wherein the ineffective rate is 0 point, the effect is not obvious 1 point, the effect is obvious 4 points, and the cure rate can be completely 5 points;

effective rate is { number of people with unobvious effect (1 point) X number + number of people with obvious effect (4 points) X number + number of people with complete cure (5 points) X } X100% } effective rate;

the table shows that the treatment effect of the toothpaste on the dental ulcer can be remarkably improved due to the increase of the contents of the sodium azulene sulfonate, the dipotassium glycyrrhizinate, the honeysuckle flower extract and other components.

The preparation method of the toothpaste for dental ulcer comprises the following operation steps:

the preparation method comprises the following steps of (1) adopting a paste making machine, wherein the paste making machine has stirring and homogenizing functions, and can work in a vacuum environment, starting a main machine, and conveying sorbitol and purified water into the main machine through a pump body;

starting a vacuum pump on the host machine, starting homogenizing equipment inside the host machine, sucking the friction agent and the thickening agent into the host machine by the vacuum pump, stirring and mixing the materials, and homogenizing the materials;

pumping Mentholum, sodium azulene sulfonate, dipotassium glycyrrhizinate, sucralose and flos Lonicerae extract into a host machine by a vacuum pump, and stirring and mixing;

then absorbing surfactant, stirring, mixing and homogenizing;

and finally, sucking food-grade essence, stirring and homogenizing for several minutes, then closing the homogenizing equipment, stirring the paste for several minutes, and then closing the main machine to finish the paste preparation operation.

Wherein, the main function of the abrasive is to remove dirt and colored substances attached to the surface of teeth; the function of the sorbitol as the humectant is to prevent the water in the paste from evaporating, even absorb the water in the air, prevent the paste from being dried and hardened, prevent the paste from being difficult to be placed and cannot reduce the freezing point of the toothpaste; the surfactant has the functions of generating foam, quickly diffusing in the oral cavity and easily inducing the fragrance of the essence; the thickener mainly has the functions of preventing the separation of powder components and liquid components of the toothpaste and improving the viscoelasticity and the shape of the toothpaste; the sodium azulene sulfonate is safe and non-toxic, has the killing rate on streptococcus mutans, staphylococcus aureus, candida albicans and escherichia coli of more than 99.98 percent, has the killing rate on porphyromonas gingivalis of more than 98.14 percent, and has the obvious effects of inhibiting dental plaque, relieving gingivitis and promoting healing of recurrent oral ulcer; the dipotassium glycyrrhizinate has the purity of 98 percent, has special sweet taste, good water solubility and pure mouthfeel, and has various effects of bacteriostasis, inflammation diminishing, detoxification, anti-allergy, deodorization and the like; the honeysuckle flower extract has the effects of resisting bacteria and enhancing the immune function, and experiments show that the honeysuckle flower extract has the inhibiting effect on typhoid bacillus, paratyphoid bacillus, escherichia coli, proteus, pseudomonas aeruginosa, bordetella pertussis, vibrio cholerae, staphylococcus, streptococcus, diplococcus pneumoniae, meningococcus and the like.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.