阅读说明：本技术 一种全降解的医用包装袋及其制备方法 (Fully-degradable medical packaging bag and preparation method thereof ) 是由 张新苗 谢永磊 陈惠� 王保华 朱辉 梁华飞 阿力木江斯迪克 刘坤 曾舒翀 于 2020-12-24 设计创作，主要内容包括：本发明公开了一种全降解的医用包装袋,包括以下各组分原料：聚羟基丁酸酯/海藻纤维复合粒子、淀粉/聚己内酯复合粒子、聚乳酸粒子、亚麻纤维、纳米二氧化钛、蔗糖硬脂酸酯、甘氨酸、酪氨酸以及填充剂。本发明的优点在于：本发明的全降解的医用包装袋可降解性好,在自然界土壤的环境下不需要太长时间即可达到全降解,且包装袋的物理性能也能达到正常医用包装袋的使用要求,适合推广使用。(The invention discloses a fully-degradable medical packaging bag which comprises the following raw materials: polyhydroxybutyrate/alginate fiber composite particles, starch/polycaprolactone composite particles, polylactic acid particles, flax fibers, nano titanium dioxide, sucrose stearate, glycine, tyrosine and a filler. The invention has the advantages that: the fully degradable medical packaging bag has good degradability, can be fully degraded in the natural soil environment without long time, has physical properties meeting the use requirements of normal medical packaging bags, and is suitable for popularization and use.)

1. A fully-degradable medical packaging bag is characterized by comprising the following raw materials in parts by weight:

30-50 parts of polyhydroxybutyrate/alginate fiber composite particles

40-60 parts of starch/polycaprolactone composite particles

20-25 parts of polylactic acid particles

10-15 parts of flax fiber

1-2 parts of nano titanium dioxide

1.2 to 1.6 portions of sucrose stearate

0.2 to 0.4 portion of glycine

Tyrosine 0.2-0.4 part

3-8 parts of a filling agent;

the preparation method of the polyhydroxybutyrate/alginate fiber composite particle comprises the following steps: polyhydroxybutyrate and alginate fibers treated by a silane coupling agent are mixed according to a mass ratio of 60: (30-40) preparing a mixture, and carrying out melt blending and extrusion granulation to obtain polyhydroxybutyrate/alginate fiber composite particles; the preparation method of the starch/polycaprolactone composite particle comprises the following steps: mixing starch and polycaprolactone, adding maleic anhydride, melting, blending, extruding and granulating to obtain the starch/polycaprolactone composite particles.

2. The fully degradable medical packaging bag according to claim 1, which is characterized by comprising the following raw materials in parts by weight:

40 parts of polyhydroxybutyrate/alginate fiber composite particles

50 parts of starch/polycaprolactone composite particle

Polylactic acid particle 22 parts

Flax fiber 12 parts

1.5 parts of nano titanium dioxide

Sucrose stearate 1.4 parts

0.3 part of glycine

Tyrosine 0.3 part

And 5 parts of a filling agent.

3. The fully degradable medical packaging bag according to claim 1, wherein the mass ratio of the starch, the polycaprolactone and the maleic anhydride in the preparation method of the starch/polycaprolactone composite particle is 50: 40: (0.4-1.1).

4. The fully degradable medical packaging bag as claimed in claim 1, wherein the flax fiber has a diameter of 0.2-0.3 μm, a length of 600-800 μm, a dry breaking strength of 1.6cN/dtex, and a defect content of 25mg/100g or less.

5. The fully degradable medical packaging bag as claimed in claim 1, wherein the weight average molecular weight of the polylactic acid particles is 80000-200000.

6. The fully degradable medical packaging bag as claimed in claim 1 or 2, wherein the filler is calcium carbonate powder and/or talcum powder, and the particle size is 4000-6000 mesh.

7. The fully degradable medical packaging bag according to claim 1, wherein the nano titanium dioxide is rutile type nano titanium dioxide with a particle size of 20-50 nm.

8. The method for preparing a fully degradable medical packaging bag according to claim 1, which is characterized by comprising the following steps:

s1, drying the starch/polycaprolactone composite particles, the polyhydroxybutyrate/alginate fiber composite particles and the polylactic acid particles in parts by weight in vacuum for 1-1.5h at the temperature of 40-45 ℃ and the vacuum degree of 0.12-0.15MPa to obtain dried granules;

s2, putting the dried granules in the S1, the flax fibers, the nano titanium dioxide and the filler in parts by weight into a high-speed mixer, mixing for 1.5-2h, then adding the sucrose stearate, the glycine and the tyrosine in parts by weight, mixing and stirring for 0.5-1h to obtain a primary mixture;

s3, carrying out vacuum drying on the primary mixture in the S2 again for 0.5-0.6h at the temperature of 35-45 ℃ and the vacuum degree of 0.08-0.12MPa to obtain a dried primary mixture;

s4, putting the dried primary mixture in the S3 into a double-screw extruder for extrusion treatment, melting and blending, extruding and granulating;

and S5, performing film blowing molding on the raw materials extruded and granulated in the S4 through a single-screw extruder, and making bags after the film blowing molding, thus obtaining the fully-degradable medical packaging bag.

9. The method for preparing a fully degradable medical packaging bag as claimed in claim 8, wherein the head temperature of the single-screw extruder is 190-200 ℃ during the film blowing molding process; the temperature of the machine barrel is divided into three regions, namely a region 150-.

10. The use of the fully degradable medical packaging bag of claim 1 as a medical CT film bag, a medical color ultrasound film bag, a medical B ultrasound film bag and a medical MR film bag.

Technical Field

The invention relates to the technical field of medical packaging bags, in particular to a fully-degradable medical packaging bag and a preparation method thereof.

Background

The existing medical packaging bags are often not degradable or have poor degradability, and if the degradable materials are prepared by modifying components with strong degradability, the physical properties of the materials often cannot meet the requirements.

Disclosure of Invention

In view of the above, the present invention is directed to a fully degradable medical packaging bag, which has good degradation performance and physical properties meeting the requirements.

In order to achieve the purpose, the technical scheme of the invention is realized by comprising the following raw materials in parts by weight:

30-50 parts of polyhydroxybutyrate/alginate fiber composite particles

40-60 parts of starch/polycaprolactone composite particles

20-25 parts of polylactic acid particles

10-15 parts of flax fiber

1-2 parts of nano titanium dioxide

1.2 to 1.6 portions of sucrose stearate

0.2 to 0.4 portion of glycine

Tyrosine 0.2-0.4 part

3-8 parts of a filling agent;

the preparation method of the polyhydroxybutyrate/alginate fiber composite particle comprises the following steps: polyhydroxybutyrate and alginate fibers treated by a silane coupling agent are mixed according to a mass ratio of 60: (30-40) preparing a mixture, and carrying out melt blending and extrusion granulation to obtain polyhydroxybutyrate/alginate fiber composite particles; the preparation method of the starch/polycaprolactone composite particle comprises the following steps: mixing starch and polycaprolactone, adding maleic anhydride, melting, blending, extruding and granulating to obtain the starch/polycaprolactone composite particles.

The paint comprises the following raw materials in parts by weight:

40 parts of polyhydroxybutyrate/alginate fiber composite particles

50 parts of starch/polycaprolactone composite particle

Polylactic acid particle 22 parts

Flax fiber 12 parts

1.5 parts of nano titanium dioxide

Sucrose stearate 1.4 parts

0.3 part of glycine

Tyrosine 0.3 part

And 5 parts of a filling agent.

In the preparation method of the starch/polycaprolactone composite particle, the mass ratio of starch to polycaprolactone to maleic anhydride is 50: 40: (0.4-1.1).

The diameter of the flax fiber is 0.2-0.3 mu m, the length is 600-800 mu m, the dry fracture strength is more than or equal to 1.6cN/dtex, and the defect content is less than or equal to 25mg/100 g.

The weight average molecular weight of the polylactic acid particles is 80000-200000.

The filler is calcium carbonate powder and/or talcum powder, and the particle size of the filler is 4000-6000 meshes.

The nano titanium dioxide is rutile type nano titanium dioxide with the particle size of 20-50 nm.

A preparation method of a fully degradable medical packaging bag comprises the following steps:

s1, drying the starch/polycaprolactone composite particles, the polyhydroxybutyrate/alginate fiber composite particles and the polylactic acid particles in parts by weight in vacuum for 1-1.5h at the temperature of 40-45 ℃ and the vacuum degree of 0.12-0.15MPa to obtain dried granules;

s2, putting the dried granules in the S1, the flax fibers, the nano titanium dioxide and the filler in parts by weight into a high-speed mixer, mixing for 1.5-2h, then adding the sucrose stearate, the glycine and the tyrosine in parts by weight, mixing and stirring for 0.5-1h to obtain a primary mixture;

s3, carrying out vacuum drying on the primary mixture in the S2 again for 0.5-0.6h at the temperature of 35-45 ℃ and the vacuum degree of 0.08-0.12MPa to obtain a dried primary mixture;

s4, putting the dried primary mixture in the S3 into a double-screw extruder for extrusion treatment, melting and blending, extruding and granulating;

and S5, performing film blowing molding on the raw materials extruded and granulated in the S4 through a single-screw extruder, and making bags after the film blowing molding, thus obtaining the fully-degradable medical packaging bag.

In the process of film blowing and forming, the temperature of the head of a single-screw extruder is 190-200 ℃; the temperature of the machine barrel is divided into three regions, namely a region 150-.

A fully degradable medical packing bag can be used as CT film bag, color ultrasonic film bag, B ultrasonic film bag and MR film bag.

The invention has the advantages that: the fully degradable medical packaging bag has good degradability, can be fully degraded in the natural soil environment without long time, has physical properties meeting the use requirements of normal medical packaging bags, and is suitable for popularization and use.

Detailed Description

The present invention will be further illustrated with reference to the following examples.

A fully-degradable medical packaging bag comprises the following raw materials: polyhydroxybutyrate/alginate fiber composite particles, starch/polycaprolactone composite particles, polylactic acid particles, flax fibers, nano titanium dioxide, sucrose stearate, glycine, tyrosine and a filler;

the preparation method of the polyhydroxybutyrate/alginate fiber composite particle comprises the following steps: polyhydroxybutyrate and alginate fibers treated by a silane coupling agent are mixed according to a mass ratio of 60: (30-40) preparing a mixture, and carrying out melt blending and extrusion granulation to obtain polyhydroxybutyrate/alginate fiber composite particles; the preparation method of the starch/polycaprolactone composite particle comprises the following steps: mixing starch and polycaprolactone, adding maleic anhydride, melting, blending, extruding and granulating to obtain the starch/polycaprolactone composite particles.

A preparation method of a fully degradable medical packaging bag comprises the following steps:

s1, carrying out vacuum drying on the starch/polycaprolactone composite particles, the polyhydroxybutyrate/alginate fiber composite particles and the polylactic acid particles for 1-1.5h at the temperature of 40-45 ℃ and the vacuum degree of 0.12-0.15MPa to obtain dried granules;

s2, putting the dried granules in the S1, the flax fibers, the nano titanium dioxide and the filler into a high-speed mixer, mixing for 1.5-2h, then adding sucrose stearate, glycine and tyrosine, mixing and stirring for 0.5-1h to obtain a primary mixture;

s3, carrying out vacuum drying on the primary mixture in the S2 again for 0.5-0.6h at the temperature of 35-45 ℃ and the vacuum degree of 0.08-0.12MPa to obtain a dried primary mixture;

s4, putting the dried primary mixture in the S3 into a double-screw extruder for extrusion treatment, melting and blending, extruding and granulating;

and S5, performing film blowing molding on the raw materials extruded and granulated in the S4 through a single-screw extruder, and making bags after the film blowing molding, thus obtaining the fully-degradable medical packaging bag.

In the process of film blowing and forming, the temperature of the head of a single-screw extruder is 190-200 ℃; the temperature of the machine barrel is divided into three regions, namely a region 150-.

A fully degradable medical packing bag can be used as CT film bag, color ultrasonic film bag, B ultrasonic film bag and MR film bag.

< example 1>

A fully-degradable medical packaging bag comprises the following raw materials in parts by weight:

30 portions of polyhydroxybutyrate/alginate fiber composite particles

40 parts of starch/polycaprolactone composite particle

Polylactic acid particle 20 parts

10 parts of flax fiber

1 part of nano titanium dioxide

Sucrose stearate 1.2 parts

0.2 part of glycine

Tyrosine 0.2 part

3 parts of a filling agent;

in the preparation method of the starch/polycaprolactone composite particle, the mass ratio of starch to polycaprolactone to maleic anhydride is 50: 40: 0.4.

the diameter of the flax fiber is 0.2 μm, the length is 600 μm, the dry breaking strength is more than or equal to 1.6cN/dtex, and the defect content is less than or equal to 25mg/100 g.

The weight average molecular weight of the polylactic acid particles is 80000.

The filler is calcium carbonate powder and/or talcum powder, and the particle size of the filler is 4000 meshes.

The nano titanium dioxide is rutile type nano titanium dioxide with the particle size of 20 nm.

< example 2>

A fully-degradable medical packaging bag comprises the following raw materials in parts by weight:

50 parts of polyhydroxybutyrate/alginate fiber composite particle

60 parts of starch/polycaprolactone composite particles

Polylactic acid particle 25 parts

15 parts of flax fiber

2 portions of nano titanium dioxide

Sucrose stearate 1.6 parts

0.4 part of glycine

Tyrosine 0.4 part

8 parts of a filling agent;

in the preparation method of the starch/polycaprolactone composite particle, the mass ratio of starch to polycaprolactone to maleic anhydride is 50: 40: 1.1.

the diameter of the flax fiber is 0.3 mu m, the length is 800 mu m, the dry breaking strength is more than or equal to 1.6cN/dtex, and the defect content is less than or equal to 25mg/100 g.

The weight average molecular weight of the polylactic acid particles is 200000.

The filler is calcium carbonate powder and/or talcum powder, and the particle size of the filler is 6000 meshes.

The nano titanium dioxide is rutile type nano titanium dioxide with the particle size of 50 nm.

< example 3>

A fully-degradable medical packaging bag comprises the following raw materials in parts by weight:

40 parts of polyhydroxybutyrate/alginate fiber composite particles

50 parts of starch/polycaprolactone composite particle

Polylactic acid particle 22 parts

Flax fiber 12 parts

1.5 parts of nano titanium dioxide

Sucrose stearate 1.4 parts

0.3 part of glycine

Tyrosine 0.3 part

5 parts of a filling agent;

in the preparation method of the starch/polycaprolactone composite particle, the mass ratio of starch to polycaprolactone to maleic anhydride is 50: 40: 0.8.

the diameter of the flax fiber is 0.25 μm, the length is 700 μm, the dry breaking strength is more than or equal to 1.6cN/dtex, and the defect content is less than or equal to 25mg/100 g.

The weight average molecular weight of the polylactic acid particles is 150000.

The filler is calcium carbonate powder and/or talcum powder, and the particle size of the filler is 5000 meshes.

The nano titanium dioxide is rutile type nano titanium dioxide with the particle size of 35 nm.

< test data >

A first test item: commercially available degradable medical packaging bags (Weixin Maindi medical products, Guangzhou, Inc.) and fully degradable medical packaging bags produced according to examples 1-3 of the present invention were compared for their degradation rates when buried in natural soils.

TABLE 1 degradation Rate comparison Table

As can be seen from Table 1, the fully degradable medical packaging bags produced in examples 1 to 3 were all completely degraded after being buried in natural soil for 180 days, and exhibited excellent degradation properties.

And (2) test item II: the properties of a commercially available medical packaging bag (Hubeikang New Garden environmental protection science and technology Co., Ltd.) and a fully degradable medical packaging bag produced according to examples 1 to 3 of the present invention were compared.

From the experimental test data it can be observed that: the medical packaging bag has good degradability, can achieve full degradation without long time under the environment of natural soil, has physical properties meeting the use requirements of normal medical packaging bags, and is suitable for popularization and use.