阅读说明：本技术 固定装置 (Fixing device ) 是由 伍兵 洪金省 王锃 于 2020-11-17 设计创作，主要内容包括：本发明公开了一种固定装置,本装置包括基座,基座上具有开设有开口且用于放置待测物的承载台和与承载台相连的支撑壁；夹持件,与支撑壁可滑动设置,且夹持件可操作地相对于承载台的方向运动；承载台和支撑壁与夹持件围绕形成照射区,其中至少部分夹持件可操作地贯穿承载台的开口夹持待测物并将待测物的局部区域拉至照射区；定位连接件,连接夹持件和支撑壁,并将夹持件定位在照射区的预设位；以及弹性件,设置在夹持件上,可操作地控制夹持件夹紧或松开待测物。本装置可将非麻醉状态下的实验动物的皮肤固定并在放射线照射下获取皮肤损伤模型,操作方便,结构简单,成本较低。(The invention discloses a fixing device, which comprises a base, wherein the base is provided with a bearing table and a supporting wall, wherein the bearing table is provided with an opening and used for placing an object to be detected, and the supporting wall is connected with the bearing table; the clamping piece is slidably arranged with the supporting wall and can move relative to the direction of the bearing table in an operable way; the bearing table, the supporting wall and the clamping piece surround to form an irradiation area, wherein at least part of the clamping piece can penetrate through the opening of the bearing table to clamp the object to be tested and draw a local area of the object to be tested to the irradiation area; the positioning connecting piece is connected with the clamping piece and the supporting wall and used for positioning the clamping piece at a preset position of the irradiation area; and the elastic piece is arranged on the clamping piece and is operable to control the clamping piece to clamp or release the object to be tested. The device can fix the skin of the experimental animal in a non-anesthesia state and obtain the skin injury model under the radiation irradiation, and has the advantages of convenient operation, simple structure and lower cost.)

1. A fixation device, comprising:

the device comprises a base, a positioning device and a positioning device, wherein the base is provided with a bearing platform which is provided with an opening and used for placing an object to be detected and a supporting wall connected with the bearing platform;

the clamping piece is slidably arranged with the supporting wall and can move relative to the direction of the bearing table in an operable way; the bearing table, the support wall and the clamping piece surround to form an irradiation area, wherein at least part of the clamping piece can penetrate through the opening of the bearing table to clamp the object to be tested and draw a local area of the object to be tested to the irradiation area;

the positioning connecting piece is connected with the clamping piece and the supporting wall and used for positioning the clamping piece at a preset position of the irradiation area; and

and the elastic piece is arranged on the clamping piece and can be used for operably controlling the clamping piece to clamp or release the object to be tested.

2. The fixture according to claim 1, wherein the support wall comprises: the first side wall and the second side wall are arranged oppositely, and the bearing table, the first side wall and the second side wall and the clamping piece surround to form the irradiation area; the clamping piece is connected with the first side wall and the second side wall through the positioning connecting piece and is arranged in a sliding mode with the first side wall and the second side wall.

3. A fixation device as claimed in claim 2, wherein the locating connection is a resilient member.

4. A fixation device as claimed in claim 3, wherein the resilient member comprises first and second oppositely disposed resilient portions;

the first elastic returning part is connected with the clamping piece and the first side wall; the second resilient portion connects the clip and the second sidewall.

5. The fixture according to claim 4, wherein the clamp comprises: the clamping body penetrates through the sliding block;

the clamping body includes: the clamping device comprises a first clamping part, a second clamping part and a connecting shaft for connecting the first clamping part, the second clamping part and the sliding block, wherein the first clamping part and the second clamping part are hinged with the connecting shaft;

the first clamping part is provided with a first chuck end and a first handle end which are integrally connected, the second clamping part is provided with a second chuck end and a second handle end which are integrally connected, and the first handle end and the second handle end can rotate around the connecting shaft to control the first chuck end and the second chuck end to move relatively; wherein the elastic member is tightly connected with the first clamping head end and the second clamping head end.

6. A fastening device according to claim 5, wherein the first and second side walls are oppositely provided with first and second ramps respectively, the slider being slidably disposed in the first and second ramps.

7. The fixing device of claim 6, wherein the bottoms of the first slideway and the second slideway are respectively provided with a first toothed groove and a second toothed groove which are oppositely arranged;

the bottom of the sliding block is provided with a first sliding block tooth groove matched with the first tooth groove and a second sliding block tooth groove matched with the second tooth groove.

8. The fixture according to claim 7, wherein the top of the first runner has a first limit plate disposed opposite the first tooth slot, and the top of the second runner has a second limit plate disposed opposite the second tooth slot; wherein the first and second limiting plates are both spaced apart from the plummer.

9. The fixing device according to claim 7, wherein the first side wall and the second side wall are respectively provided with a first fixing position and a second fixing position at one end far away from the bearing platform, and the first fixing position and the second fixing position are respectively arranged at the side close to the first tooth groove and the second tooth groove; wherein the first resilient portion connects the first fixing location and the slider, and the second resilient portion connects the second fixing location and the slider.

10. The fixture according to claim 2, wherein the susceptor is an arc-shaped stage recessed into the irradiation zone.

11. The fixture according to claim 10, wherein the carrier has a connecting portion connecting the first and second sidewalls, and a first and second extending portion respectively connected to both ends of the connecting portion.

12. The securing device of claim 2, wherein the opening extends at least partially between the first sidewall and the second sidewall.

13. The fixture of claim 1, wherein said base and clamp are made of nylon or plastic, and said positioning connection and said spring are made of a non-metallic spring material.

Technical Field

The invention relates to the field of experimental equipment, in particular to a fixing device.

Background

Radiotherapy is one of the most important methods for treating malignant tumors, and skin is the indispensable way for irradiation, so that the skin can be damaged to different degrees while tumor cells are killed, and the research on the specific mechanism of radioactive skin damage is not clear at present, and a suitable animal model is mainly lacked. Because the existing mode of modeling the radioactive skin injury is mainly to irradiate the leg skin and the back skin of a mouse after the mouse is anesthetized, important organs such as internal organs, bone marrow and the like are inevitably injured, a simple animal model only damaging the skin cannot be obtained, and great interference is caused to the research of the radioactive skin injury mechanism. And usually before fixed to mouse skin, still need to carry out the anesthesia to the mouse, not only whole anesthesia process is wasted time and energy, and anesthesia itself has certain lethal risk, can not guarantee that the mouse can wake up by a hundred percent, and in addition under the anesthesia state, the mouse breathes slowly and weakens, also can lead to the mouse because of choking death at the in-process of tractive skin.

Disclosure of Invention

The invention aims to provide a fixing device which can fix the skin of an experimental animal in a non-anesthesia state and obtain a skin injury model under the irradiation of radioactive rays, and has the advantages of convenient operation, simple structure and lower cost.

To solve the above technical problem, an embodiment of the present invention provides a fixing device, including: the device comprises a base, a positioning device and a positioning device, wherein the base is provided with a bearing platform which is provided with an opening and used for placing an object to be detected and a supporting wall connected with the bearing platform;

the clamping piece is slidably arranged with the supporting wall and can move relative to the direction of the bearing table in an operable way; the bearing table, the support wall and the clamping piece surround to form an irradiation area, wherein at least part of the clamping piece can penetrate through the opening of the bearing table to clamp the object to be tested and draw a local area of the object to be tested to the irradiation area;

the positioning connecting piece is connected with the clamping piece and the supporting wall and used for positioning the clamping piece at a preset position of the irradiation area;

and the elastic piece is arranged on the clamping piece and can be used for operably controlling the clamping piece to clamp or release the object to be tested.

Compared with the prior art, the device has the advantages that the clamping piece penetrates through the opening of the bearing table to enable the clamping piece to pull and fix part of the skin area of the experimental animal in the non-anesthesia state to the irradiation area, so that the experimental animal is exposed to the radioactive rays for irradiation, and therefore the skin injury model is obtained.

In some embodiments, the support wall comprises: the first side wall and the second side wall are arranged oppositely, and the bearing table, the first side wall and the second side wall and the clamping piece surround to form the irradiation area; the clamping piece is connected with the first side wall and the second side wall through the positioning connecting piece and is arranged in a sliding mode with the first side wall and the second side wall.

In some embodiments, the positioning connection is a resilient member.

In some embodiments, the resilient member comprises first and second oppositely disposed resilient portions; the first elastic returning part is connected with the clamping piece and the first side wall; the second resilient portion connects the clip and the second sidewall.

In some embodiments, the clamp comprises: the clamping body penetrates through the sliding block;

the clamping body includes: the clamping device comprises a first clamping part, a second clamping part and a connecting shaft for connecting the first clamping part, the second clamping part and the sliding block, wherein the first clamping part and the second clamping part are hinged with the connecting shaft;

the first clamping part is provided with a first chuck end and a first handle end which are integrally connected, the second clamping part is provided with a second chuck end and a second handle end which are integrally connected, and the first handle end and the second handle end can rotate around the connecting shaft to control the first chuck end and the second chuck end to move relatively; wherein the elastic member is tightly connected with the first clamping head end and the second clamping head end.

In some embodiments, the first and second side walls are provided with first and second slides, respectively, opposite to each other, in which the slider is slidably disposed.

In some embodiments, the bottoms of the first slideway and the second slideway are respectively provided with a first tooth socket and a second tooth socket which are oppositely arranged;

the bottom of the sliding block is provided with a first sliding block tooth groove matched with the first tooth groove and a second sliding block tooth groove matched with the second tooth groove.

In some embodiments, the top of the first slideway has a first limit plate disposed opposite to the first tooth slot, and the top of the second slideway has a second limit plate disposed opposite to the second tooth slot; wherein the first and second limiting plates are both spaced apart from the plummer.

In some embodiments, the first side wall and the second side wall are respectively provided with a first fixing position and a second fixing position at one end far away from the bearing table, and the first fixing position and the second fixing position are respectively arranged at the side close to the first tooth groove and the second tooth groove; wherein the first resilient portion connects the first fixing location and the slider, and the second resilient portion connects the second fixing location and the slider.

In some embodiments, the susceptor is an arc-shaped stage that is concave toward the inside of the irradiation zone.

In some embodiments, the carrier has a connecting portion connecting the first sidewall and the second sidewall, and a first extending portion and a second extending portion respectively connected to two ends of the connecting portion.

In some embodiments, the opening extends at least partially between the first sidewall and the second sidewall.

In some embodiments, the base and clamp are made of nylon or plastic, and the positioning connection and the spring are made of a non-metallic resilient material.

Drawings

FIG. 1 is a schematic structural diagram of a fixing device according to an embodiment of the present invention;

FIG. 2 is a schematic view of another embodiment of a fixing device;

fig. 3 is an exploded view of a fixture according to an embodiment of the present invention.

DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION

The embodiments of the present invention will be described in detail below with reference to the accompanying drawings in order to more clearly understand the objects, features and advantages of the present invention. It should be understood that the embodiments shown in the drawings are not intended to limit the scope of the present invention, but are merely intended to illustrate the spirit of the technical solution of the present invention.

In the following description, for the purposes of illustrating various disclosed embodiments, certain specific details are set forth in order to provide a thorough understanding of the various disclosed embodiments. One skilled in the relevant art will recognize, however, that the embodiments may be practiced without one or more of the specific details. In other instances, well-known devices, structures and techniques associated with this application may not be shown or described in detail to avoid unnecessarily obscuring the description of the embodiments.

Throughout the specification and claims, the word "comprise" and variations thereof, such as "comprises" and "comprising," are to be understood as an open, inclusive meaning, i.e., as being interpreted to mean "including, but not limited to," unless the context requires otherwise.

Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases "in one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.

As used in this specification and the appended claims, the singular forms "a", "an", and "the" include plural referents unless the context clearly dictates otherwise. It should be noted that the term "or" is generally employed in its sense including "and/or" unless the context clearly dictates otherwise.

In the following description, for the purposes of clearly illustrating the structure and operation of the present invention, directional terms will be used, but terms such as "front", "rear", "left", "right", "outer", "inner", "outer", "inward", "upper", "lower", etc. should be construed as words of convenience and should not be construed as limiting terms.

Embodiments of the present invention are described below with reference to the drawings. In this embodiment, as shown in fig. 1 and fig. 2, the fixing device of this embodiment is used for constructing a model of mouse radioactive skin injury, and specifically includes: base 1, holder 2, location connecting piece 3 and elastic component 4. The base 1 comprises a bearing table 5 and a supporting wall 6, the bearing table 5 being connected with the supporting wall 6. The susceptor 5 is provided with an opening 7. The support wall 6 includes a first side wall 61 and a second side wall 62 which are oppositely disposed. The clamping piece 2 is arranged between the first side wall 61 and the second side wall 62, the clamping piece 2 is slidably connected with the first side wall 61 and the second side wall 62, and the clamping piece 2, the bearing table 5, the first side wall 61 and the second side wall 62 surround to form an irradiation area 8, wherein the clamping piece 2 can slidably approach the bearing table 5 and partially penetrate through the opening 7 of the bearing table 5, clamp a mouse below the opening 7 and pull the back skin of the mouse to the irradiation area 8. The positioning connection 3 enables the connection of the holder 2 to the first side wall 61 and the second side wall 62, respectively. The positioning connector 3 is used for pulling the mouse to the irradiation region 8 and positioning the clamping member 2 at the preset position of the irradiation region 8 after the clamping member 2 clamps the back skin of the mouse. In addition, the clamping piece 2 is also provided with an elastic piece 4 for controlling the clamping piece 2 to clamp or loosen the back skin of the mouse.

Specifically, the carrier table 5 is an arc-shaped table recessed toward the irradiation region 8, and in some embodiments, the carrier table 5 includes a connecting portion 50 connecting a first side wall 61 and a second side wall 62, and further includes a first extending portion 51 and a second extending portion 52 connected to both ends of the connecting portion 50. Bearing platform 5 can be a baffle of imitative mouse back profile, if the mouse changes other determinand, the radian of arc platform also can correspondingly change for bearing platform 5 and determinand more agreeing, better bear and stabilize the determinand. The plummer 5 is connected to the first side wall 61 and the second side wall 62, and may be integrally connected or separately connected. The carrier 5 has an opening 7, the opening 7 at least partially extends between the first side wall 61 and the second side wall 62, and the opening 7 is preferably a long and narrow cross-shaped slit. It should be noted that the supporting wall is not limited to the form of a partition wall of the first side wall 61 and the second side wall 62, and may also be, for example, a separate bottom plate connected to the carrier table 5, which is not limited herein.

As shown in fig. 3, the clamp 2 includes a clamp body 9 and a slider 10. The clamping body 9 comprises a first clamping part 91, a second clamping part 92 and a connecting shaft 93, wherein the connecting shaft 93 is used for connecting the sliding block 10 with the first clamping part 91 and the second clamping part 92, and the first clamping part 91 and the second clamping part 92 are connected with the connecting shaft 93 through hinges. The first clamping portion 91 has a first clamping head end 911 and a first shank end 912, and preferably, the first clamping head end 911 and the first shank end 912 are integrally connected. The second clamping portion 92 has a second clamping head end 921 and a second handle end 922, and preferably, the second clamping head end 921 and the second handle end 922 are integrally connected. The first handle end 912 and the second handle end 922 can rotate around the connecting shaft 93 to control the relative movement of the first clip end 911 and the second clip end 921, and the first clip end 911 and the second clip end 921 are tightly connected through the elastic element 4. The elastic member 4 may be a rubber band, and a clamping force of the first clip head end 911 and the second clip head end 921 against each other is formed by winding the rubber band around the first clip head end 911 and the second clip head end 921. Thus, when a force is applied to the first handle 912 and the second handle 922, the first clip end 911 and the second clip end 921 are controlled to rotate away from each other around the connecting shaft 93, so that the skin on the back of the mouse is clamped by the clamping force of the rubber band, or the skin on the back of the mouse is loosened by applying a force to the handle of the clamping body. However, it is understood that the elastic member 4 may have other forms, such as an elastic connection member disposed between the first clip end 911 and the second clip end 921, thereby forming an elastic connection force between the first clip end 911 and the second clip end 921.

The first side wall 61 and the second side wall 62 are oppositely provided with a first slideway 11 and a second slideway 12 respectively, and the slider 10 is slidably arranged in the first slideway 11 and the second slideway 12. On the one hand, the holding part 2 can slide in the first slideway 11 and the second slideway 12 and part of the holding part 2 can pass through the opening 7, on the other hand, after the holding part 2 holds the back skin of the mouse, the positioning connecting part 3 pulls the holding part 2 together with the back skin of the mouse out of the opening 7, and the body of the mouse is blocked at the other side of the bearing table 5, so that more back skin can be pulled out to the irradiation area 8. The positioning and connecting piece 3 is made of non-metallic material, preferably a resilient piece. The resilient member comprises a first resilient part 31 and a second resilient part 32 which are oppositely arranged, the first resilient part 31 and the second resilient part 32 can be rubber ropes or other elastic ropes, wherein the first resilient part 31 connects the slider 10 and the first side wall 61; the second resilient portion 32 connects the slider 10 and the second side wall 62. In addition, the first resilient portion 31 and the second resilient portion 32 may be integrally connected or may be separated, and are not limited herein.

When the device is used on a laboratory bench, the first handle end 912 of the first clamping part 91 and the second handle end 922 of the second clamping part 92 can be held by the thumb and the forefinger of the right hand, and pressed downwards, so that the first clip end 911 and the second clip end 921 are opened and extend out of the opening 7. Then the left hand carries the mouse tail and places the mouse on the laboratory bench, and the right hand pastes plummer 5 at the mouse back, loosens first handle end 912 and second handle end 922, makes first press from both sides head 911 and second press from both sides head 921 and presss from both sides mouse back skin. Finally, the first handle end 912 and the second handle end 922 are released, and the clamping member 2 slides to the top of the base 1 under the action of the first resilient portion 31 and the second resilient portion 32, so that the skin on the back of the mouse is dragged into the irradiation region 8 and is stretched out by pulling as much as possible. After the completion, the device is placed on the side, the back skin of the mouse in the irradiation region 8 and the irradiation table top are kept horizontal, and after the arrangement, the back skin of the mouse in the irradiation region 8 can be irradiated by radioactive rays, so that a relevant radioactive skin injury model (including acute radiodermatitis, skin ulcer and chronic radioactive skin fibrosis) is constructed. It should be noted that, because the device is used in the radiation irradiation environment, the device components cannot include metal components, the base 1 and the holding member 2 can be made of nonmetal such as nylon, plastic, etc., and the positioning connecting member 3 and the elastic member 4 can be made of nonmetal elastic material, which is not specifically limited.

This device lets the holder pull to and fix the exposure area with the partial skin of experimental animals under the non-anesthesia state through the opening with the holder pass the plummer, makes it expose and shine under the radiation, because only skin area exposes and shines under the radiation, and other parts of the body can not receive and shine to avoid hindering important organs such as internal organs and marrow, obtain the animal model that only skin damage, and simple structure, convenient operation, the cost is lower. In addition, because the mouse does not need to be anesthetized in the operation process, the risk of death caused by anesthesia is avoided.

In some embodiments, the bottoms of the first slideway 11 and the second slideway 12 are respectively provided with a first tooth slot 13 and a second tooth slot 14 which are oppositely arranged, and both the first tooth slot 13 and the second tooth slot 14 are provided with sawtooth structures; the bottom of the slider 10 has a first slider spline (not shown) disposed opposite to the first spline 13, and a second slider spline (not shown) disposed opposite to the second spline 14. The first slider tooth groove and the second slider tooth groove are also provided with sawtooth structures. Specifically, when the clip 2 slides in the first and second slideways 11 and 12, the clip 2 can be restrained by pressing the slider 10 downward toward the first and second tooth grooves 13 and 14 so that the first tooth groove 13 engages with the first slider tooth groove and the second tooth groove 14 engages with the second slider tooth groove as well as the clip 2. When the limit is required to be released, the slider 10 is lifted in a direction away from the first tooth groove 13 and the second tooth groove 14, so that the first tooth groove 13 is away from the first slider tooth groove to release the engagement of the saw teeth, and the second tooth groove 14 is also away from the second slider tooth groove to release the engagement of the saw teeth. The position of holder 2 can be adjusted through the block of different positions sawtooth, and then can adjust the distance that drags mouse back skin, adjusts the power size of dragging to mouse back skin promptly to this adaptation different experimental scenes. In some embodiments, the top of the first runner 11 has a first limit plate 51 disposed opposite the first tooth slot 13, and the top of the second runner 12 has a second limit plate 52 disposed opposite the second tooth slot 14; wherein the first and second limiting plates 51 and 52 are both separated from the carrier 5, and the separated areas are connected with the irradiation area, so that more irradiation areas are provided, larger back skin can be accommodated, and a large-area irradiation experiment is more convenient to perform.

In some embodiments, the first side wall 61 and the second side wall 62 are respectively provided with a first fixing position 81 and a second fixing position 82 at one end far away from the bearing table 5, and the first fixing position 81 and the second fixing position 82 are respectively provided at the side close to the first tooth slot 13 and the second tooth slot 14; wherein the first resilient portion 31 connects the first fixing portion 81 to the slider 10 and the second resilient portion 32 connects the second fixing portion 82 to the slider 10. Through the first fixed position 81 and the second fixed position 82 that set up, produce the slant pulling force from tooth's socket to fixed position direction on first resilience portion 31 and the second resilience portion 32, be difficult for droing when can making first tooth's socket 13 and first slider tooth's socket and second tooth's socket 14 and the block of second slider tooth's socket for the block is tighter between the sawtooth, convenient operation.

The experimental animal to which the experimental device is directed is not limited to a mouse, and may be an animal of other equivalent size class. In addition, the size of the device can be enlarged according to a certain proportion so as to be suitable for experimental animals such as rats, rabbits and the like.

While the preferred embodiments of the present invention have been described in detail above, it should be understood that aspects of the embodiments can be modified, if necessary, to employ aspects, features and concepts of the various patents, applications and publications to provide yet further embodiments.

These and other changes can be made to the embodiments in light of the above detailed description. In general, in the claims, the terms used should not be construed to be limited to the specific embodiments disclosed in the specification and the claims, but should be construed to include all possible embodiments along with the full scope of equivalents to which such claims are entitled.