阅读说明：本技术 一种甘草颗粒的制备方法及其制备的甘草颗粒 (Preparation method of liquorice particles and liquorice particles prepared by same ) 是由 范宇春 冯立宝 员鹏飞 于 2020-11-25 设计创作，主要内容包括：本发明提出了一种甘草颗粒的制备方法及其制备的甘草颗粒,涉及中药技术领域。该甘草颗粒的制备方法,包括如下步骤：将甘草经煎煮后的滤液浓缩至相对密度1.05-1.20,收集清膏；将填充剂和清膏按2.5～3.0:1混合后再加入润滑剂制粒,得到所述甘草颗粒；所述煎煮时甘草与水的重量比为1:14～15,所述煎煮时的温度为90～100℃,所述煎煮的时间为3～4h,所述润滑剂在所述甘草颗粒中的重量百分数为0.5～1.0％；所述浓缩的温度为65～85℃。本发明的优点在于,最终制备的甘草颗粒疗效更好,颗粒均匀,产品质量均匀,成品率高,有效成分含量高且符合GMP标准、符合中医用药理论和原则。(The invention provides a preparation method of liquorice particles and the liquorice particles prepared by the same, and relates to the technical field of traditional Chinese medicines. The preparation method of the licorice granules comprises the following steps: concentrating the decoction filtrate of Glycyrrhrizae radix to relative density of 1.05-1.20, and collecting fluid extract; mixing the filler and the clear paste according to a ratio of 2.5-3.0: 1, adding a lubricant, and granulating to obtain the licorice granules; the weight ratio of the liquorice to water during decoction is 1: 14-15, the temperature during decoction is 90-100 ℃, the decoction time is 3-4 h, and the weight percentage of the lubricant in the liquorice particles is 0.5-1.0%; the concentration temperature is 65-85 ℃. The invention has the advantages that the finally prepared liquorice granules have better curative effect, uniform granules, uniform product quality, high yield, high content of effective components, and accord with GMP standard and traditional Chinese medicine theory and principle.)

1. The preparation method of the liquorice particles is characterized by comprising the following steps: concentrating the decoction filtrate of Glycyrrhrizae radix to relative density of 1.05-1.20, and collecting fluid extract; mixing the filler and the clear paste according to a ratio of 2.5-3.0: 1, adding a lubricant, and granulating to obtain the licorice granules; the weight ratio of the liquorice to water during decoction is 1: 14-15, the temperature during decoction is 90-100 ℃, the decoction time is 3-4 h, and the weight percentage of the lubricant in the liquorice particles is 0.5-1.0%; the concentration temperature is 65-85 ℃.

2. The preparation method of licorice granules according to claim 1, wherein the decoction comprises two times of decoction, wherein the weight ratio of licorice to water in the first time of decoction is 1: 8-8.5, and the decoction time is 2-2.5 hours; wherein the weight ratio of the liquorice to the water in the second decoction is 1: 6-6.5, and the decoction time is 1-1.5 h.

3. The method for preparing licorice granules according to claim 1 or 2, wherein the filler is maltodextrin.

4. The method for preparing licorice granules according to claim 1 or 2, wherein the lubricant is magnesium stearate.

5. The method for preparing licorice particles according to claim 1 or 2, wherein the filtrate is concentrated after standing for 3 hours or more.

6. The method for preparing licorice granules according to claim 2, wherein the weight ratio of licorice to water in the first decoction is 1: 8; the weight ratio of the liquorice to the water during the second decoction is 1: 6.

7. The preparation method of the licorice granule according to claim 1 or 2, wherein the mixing of the filler and the fluid extract comprises the step of mixing the filler and the fluid extract for 20-30 min and then drying the mixture to obtain dry paste powder, wherein the drying temperature is 175-185 ℃.

8. The method for preparing licorice granules according to claim 7, wherein the equipment used for drying is a drying sprayer, the air outlet temperature of the drying sprayer is 85-95 ℃, and the negative pressure in the tower of the drying sprayer is-8 to-12 Pa.

9. The method for preparing licorice granules according to claim 7, further comprising the step of sieving the concentrated licorice granules to 180 to 200 meshes, sieving the concentrated licorice granules to 80 to 100 meshes after mixing the filler and the fluid extract, and sieving the dry extract powder to 80 to 100 meshes.

10. A licorice granule produced by the method for producing a licorice granule according to any one of claims 1 to 9.

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a preparation method of liquorice particles and the liquorice particles prepared by the same.

Background

The licorice is a common traditional Chinese medicine, and the Chinese pharmacopoeia collects the dry roots and rhizomes of licorice (Glycyrrhiza uralensis Fisch.) which is a leguminous plant. Collecting Glycyrrhrizae radix in spring and autumn, removing fibrous root, and sun drying to obtain decoction pieces. Licorice root, radix Glycyrrhizae is slightly fragrant, sweet in flavor, sweet in nature, cool, thin, soft and soft. Has the effects of moistening lung for arresting cough, invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and arresting cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, suppurative sore, and relieving drug toxicity and pungency. At present, liquorice on the market mostly takes liquorice decoction pieces as main materials, and during use, the liquorice is decocted at present after decoction pieces are used, but with the continuous acceleration of the pace of modern life, the traditional medication mode needs a large amount of decoction time, is inconvenient to carry, has large drinking amount, and cannot meet the pace of modern life.

Disclosure of Invention

The invention aims to provide a preparation method of licorice granules, and the licorice granules prepared by the preparation method have uniform size, stable product quality, high yield and high content of effective components, meet GMP (good manufacturing practice) standards and meet the traditional Chinese medicine medication theory and principle.

The invention also aims to provide the liquorice particles prepared by the preparation method, which not only saves the decoction time of medicinal materials, but also keeps the property of the original medicinal materials, is convenient to carry, can be eaten at any time and is more suitable for the fast-paced life of contemporary people.

The technical problem to be solved by the invention is realized by adopting the following technical scheme.

On one hand, the embodiment of the application provides a preparation method of licorice granules, which comprises the following steps: concentrating the decoction filtrate of Glycyrrhrizae radix to relative density of 1.05-1.20, and collecting fluid extract; mixing the filler and the clear paste according to a ratio of 2.5-3.0: 1, adding a lubricant, and granulating to obtain the licorice granules; the weight ratio of the liquorice to water during decoction is 1: 14-15, the temperature during decoction is 90-100 ℃, the decoction time is 3-4 h, and the weight percentage of the lubricant in the liquorice particles is 0.5-1.0%; the concentration temperature is 65-85 ℃.

In another aspect, the present application provides a licorice granule prepared by the aforementioned method.

Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:

according to the preparation method of the liquorice particles, the beneficial ingredients in the liquorice are fully reserved through a specific extraction and concentration process, and the concentrated clear paste is dried and granulated by using a drying and spraying method, so that the finally prepared liquorice particles are better in curative effect, uniform in particle, uniform in product quality, high in yield and high in effective ingredient, meet GMP (good manufacturing practice) standards, and meet the traditional Chinese medicine medication theory and principle. Compared with the traditional Chinese medicine decoction, the liquorice particles prepared by the preparation method of the liquorice particles provided by the invention not only save the decoction time of medicinal materials, but also keep the property of the original medicinal materials, are convenient to carry and can be eaten at any time, and the drinking amount is small, so that the liquorice particles are more suitable for the fast-paced life of contemporary people.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.

FIG. 1 is a flow chart of a method for preparing licorice granules provided in embodiments 1 to 6 of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.

On one hand, the embodiment of the application provides a preparation method of licorice granules, which comprises the following steps: concentrating the decoction filtrate of Glycyrrhrizae radix to relative density of 1.05-1.20, and collecting fluid extract; mixing the filler and the clear paste according to a ratio of 2.5-3.0: 1, adding a lubricant, and granulating to obtain the licorice granules; the weight ratio of the liquorice to water during decoction is 1: 14-15, the temperature during decoction is 90-100 ℃, the decoction time is 3-4 h, and the weight percentage of the lubricant in the liquorice particles is 0.5-1.0%; the concentration temperature is 65-85 ℃.

In some embodiments, the decoction comprises two times of decoction, wherein the weight ratio of the liquorice to water in the first decoction is 1: 8-8.5, and the decoction time is 2-2.5 hours; wherein the weight ratio of the liquorice to the water in the second decoction is 1: 6-6.5, and the decoction time is 1-1.5 h.

In some embodiments of the present invention, in the preparation method of the licorice granule, the filler is maltodextrin.

In some embodiments of the present invention, in the above method for preparing licorice granules, the lubricant is magnesium stearate.

In some embodiments of the method for preparing licorice granules provided by the present invention, the filtrate is left to stand for more than 3 hours and then concentrated.

In some embodiments, in the preparation method of the licorice granules, the weight ratio of licorice to water in the first decoction is 1: 8; the weight ratio of the liquorice to the water during the second decoction is 1: 6.

In some embodiments provided by the invention, the step of mixing the filler and the clear paste comprises the step of mixing the filler and the clear paste for 20-30 min and then drying to obtain dry paste powder, wherein the drying temperature is 175-185 ℃.

In some embodiments of the preparation method of the licorice granules provided by the invention, the equipment used for drying is a drying sprayer, the air outlet temperature of the drying sprayer is 85-95 ℃, and the negative pressure in a tower of the drying sprayer is-8 to-12 Pa.

In some embodiments provided by the invention, the preparation method of the licorice granules further comprises the following steps, the mesh number of the concentrated licorice granules is 180-200 meshes, the mesh number of the concentrated licorice granules obtained by mixing the filler and the clear paste is 80-100 meshes, and the mesh number of the dry paste powder is 80-100 meshes.

In another aspect, the present application provides a licorice granule prepared by the method for preparing a licorice granule described above.

The features and properties of the present invention are described in further detail below with reference to examples.

Example 1

The objective of this embodiment is to provide a licorice granule, the flow is shown in fig. 1, wherein the shaded square blocks represent the clean zone, i.e. the aseptic zone, and the unshaded square blocks represent the general working zone, comprising the following steps:

1.1 extraction and concentration:

carefully selecting impurity-free and high-quality liquorice pieces, accurately weighing 6000g of liquorice pieces, putting into an extraction tank, adding drinking water into the extraction tank, decocting twice, keeping the temperature of the water at 90-100 ℃ and decocting for 2 hours, wherein the mass of the drinking water added for the first time is 8 times of that of the liquorice pieces, heating the water in the extraction tank to boiling, and filtering the liquid medicine after the first decoction is finished to leave dregs of a decoction.

Adding drinking water 6 times the weight of the licorice decoction pieces into the dregs of a decoction, heating to boil, decocting for 1 hour, filtering out the liquid medicine of the second time after the second time of decoction is finished, combining the liquid medicine with the filtrate obtained by the first time of decoction, pumping the combined filtrate into a liquid medicine storage tank, and standing for more than 3-3.5 hours; filtering out supernatant obtained by standing, transferring into a vacuum concentration tank, operating according to the operating specification of the vacuum concentrator, opening a steam valve, vacuum concentrating to obtain fluid extract with relative density of 1.05-1.20 and temperature of 85 ℃, passing through a 180-mesh and 200-mesh sieve while hot to obtain Glycyrrhrizae radix fluid extract, and temporarily storing in a fluid extract storage tank.

1.2, preparing materials:

accurately weighing maltodextrin and licorice clear paste, wherein the mass ratio of the maltodextrin to the licorice clear paste is 2.5: 1, standby.

1.3 mixing:

gradually adding Glycyrrhrizae radix fluid extract and maltodextrin into spray dryer according to small amount, setting temperature at 180 deg.C, controlling air inlet temperature at 175 deg.C, air outlet temperature at 85 deg.C, and negative pressure at-8 Pa, mixing Glycyrrhrizae radix fluid extract and maltodextrin, stirring, collecting Glycyrrhrizae radix dry extract powder at regular time, pulverizing Glycyrrhrizae radix dry extract powder, sieving with 80 mesh sieve, adding appropriate amount of 0.5% magnesium stearate, placing in mixing tank, and mixing for 20-40 min.

1.4 dry granulation:

granulating dry licorice powder by using a dry granulator, sieving the dry licorice powder by 80-100 meshes, pouring the dry licorice powder onto the dry granulator, sieving coarse particles and fine particles by using 20-40 mesh sieves respectively, adding the coarse particles and the fine particles into the granulator again for granulation, and finally obtaining the licorice granules with the particle size of 20-40 meshes, uniform particle color, and the particle size of the granules which can not pass through the sum of a No. one sieve (10 meshes) and a No. five sieve (80 meshes) and can not exceed 15%, and warehousing after the examination is qualified.

1.5 particle:

and (4) inspecting the licorice granules obtained in the step (1.4), wherein the licorice granules are required to meet relevant regulations of quality standards of licorice formula granules, and the moisture, the granularity and the dissolubility are required to meet the regulations.

1.6, subpackaging:

and (4) subpackaging the licorice granules obtained in the step (1.4), taking a stainless steel measuring cup of a corresponding model according to the filling specification, and checking whether the measuring cup has a groove, a curled edge, a unfilled corner and abrasion. The filling is firstly carried out before filling, the filling amount difference of each measuring cup is checked, the filling amount is adjusted according to the weight of each bag, the operation is carried out according to the operation regulations of 'granule filling SOP' and granule subpackaging post, and the machine is started up formally (the production speed is 60-80 bags/min; the temperature of a longitudinal sealing roller is 100-210 ℃ and the temperature of a transverse sealing roller is 120-220 ℃) after meeting the requirements. The average bag weight was checked every 20 minutes after start-up. In the filling process, the filling amount difference and the sealing performance are controlled, and the sampling result is recorded, so that the filling amount of each bag is ensured to be in a control range. The bagged particles are put into a special container. Each bag contains 0.5g of raw medicinal materials, which is equivalent to 3 g. According to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; placing a product certificate in the outer box, sealing with sealing tape, bundling firmly, sealing, and packaging into corrugated paper box.

Example 2

The objective of this embodiment is to provide a licorice granule, the flow is shown in fig. 1, wherein the shaded square blocks represent the clean zone, i.e. the aseptic zone, and the unshaded square blocks represent the general working zone, comprising the following steps:

1.1 extraction and concentration:

carefully selecting impurity-free and high-quality liquorice pieces, accurately weighing 6000g of liquorice pieces, putting into an extraction tank, adding drinking water into the extraction tank, decocting twice, keeping the temperature of the water at 90-100 ℃ and decocting for 2.5 hours, wherein the mass of the drinking water added for the first time is 8.4 times of that of the liquorice pieces, heating the water in the extraction tank to boil, and filtering the liquid medicine after the first decoction is finished to leave dregs.

Adding drinking water 6.2 times the weight of Glycyrrhrizae radix decoction pieces into the residue, heating to boil, decocting for 1 hr, filtering the second decoction, mixing with the first decoction, pumping the mixed filtrate into a medicinal liquid storage tank, standing for 3-3.5 hr or more; filtering out supernatant obtained by standing, transferring into a vacuum concentration tank, operating according to the operating specification of the vacuum concentrator, opening a steam valve, vacuum concentrating to obtain fluid extract with relative density of 1.05-1.20 and temperature of 70 ℃, passing through a 180-mesh and 200-mesh sieve while hot to obtain Glycyrrhrizae radix fluid extract, and temporarily storing in a fluid extract storage tank.

1.2, preparing materials:

accurately weighing maltodextrin and licorice clear paste, wherein the mass ratio of the maltodextrin to the licorice clear paste is 2.6: 1, standby.

1.3 mixing:

gradually adding the licorice root clear paste and maltodextrin into a traditional Chinese medicine clear paste spray dryer according to a small amount of times, setting the temperature at 180 ℃, controlling the air inlet temperature at 175-185 ℃, the air outlet temperature at 85-95 ℃, and setting the negative pressure in a tower at-8 to-12 Pa, fully mixing the licorice root clear paste and the maltodextrin, stirring, crushing the licorice root dry paste powder, sieving by a sieve of 80-100 meshes, adding a proper amount of 0.5 percent magnesium stearate, placing the mixture in a mixing tank, and mixing for 20-40 minutes.

1.4 dry granulation:

granulating dry licorice powder by using a dry granulator, sieving the dry licorice powder by 80-100 meshes, pouring the dry licorice powder onto the dry granulator, sieving coarse particles and fine particles by using 20-40 mesh sieves respectively, adding the coarse particles and the fine particles into the granulator again for granulation, and finally obtaining the licorice granules with the particle size of 20-40 meshes, uniform particle color, and the particle size of the granules which can not pass through the sum of a No. one sieve (10 meshes) and a No. five sieve (80 meshes) and can not exceed 15%, and warehousing after the examination is qualified.

1.5 particle:

and (4) inspecting the licorice granules obtained in the step (1.4), wherein the licorice granules are required to meet relevant regulations of quality standards of licorice formula granules, and the moisture, the granularity and the dissolubility are required to meet the regulations.

1.6, subpackaging:

and (4) subpackaging the licorice granules obtained in the step (1.4), taking a stainless steel measuring cup of a corresponding model according to the filling specification, and checking whether the measuring cup has a groove, a curled edge, a unfilled corner and abrasion. The filling is firstly carried out before filling, the filling amount difference of each measuring cup is checked, the filling amount is adjusted according to the weight of each bag, the operation is carried out according to the operation regulations of 'granule filling SOP' and granule subpackaging post, and the machine is started up formally (the production speed is 60-80 bags/min; the temperature of a longitudinal sealing roller is 100-210 ℃ and the temperature of a transverse sealing roller is 120-220 ℃) after meeting the requirements. The average bag weight was checked every 20 minutes after start-up. In the filling process, the filling amount difference and the sealing performance are controlled, and the sampling result is recorded, so that the filling amount of each bag is ensured to be in a control range. The bagged particles are put into a special container. Each bag contains 0.5g of raw medicinal materials, which is equivalent to 3 g. According to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; placing a product certificate in the outer box, sealing with sealing tape, bundling firmly, sealing, and packaging into corrugated paper box.

Example 3

The objective of this embodiment is to provide a licorice granule, the flow is shown in fig. 1, wherein the shaded square blocks represent the clean zone, i.e. the aseptic zone, and the unshaded square blocks represent the general working zone, comprising the following steps:

1.1 extraction and concentration:

carefully selecting impurity-free and high-quality liquorice pieces, accurately weighing 6000g of liquorice pieces, putting into an extraction tank, adding drinking water into the extraction tank, decocting twice, keeping the temperature of the water at 90-100 ℃ and decocting for 2 hours, wherein the mass of the drinking water added for the first time is 8.2 times of that of the liquorice pieces, heating the water in the extraction tank to boil, and filtering the liquid medicine after the first decoction is finished to leave dregs of a decoction.

Adding drinking water 6.3 times the weight of the liquorice decoction pieces into the dregs of a decoction, heating to boil, decocting for 1 hour, filtering out the liquid medicine of the second time after the second time of decoction is finished, combining the liquid medicine with the filtrate obtained by the first time of decoction, pumping the combined filtrate into a liquid medicine storage tank, and standing for more than 3-3.5 hours; filtering out supernatant obtained by standing, transferring into a vacuum concentration tank, operating according to the operating specification of the vacuum concentrator, opening a steam valve, vacuum concentrating to obtain fluid extract with relative density of 1.08-1.20 and temperature of 80 ℃, passing through a 180-mesh and 200-mesh sieve while hot to obtain Glycyrrhrizae radix fluid extract, and temporarily storing in a fluid extract storage tank.

1.2, preparing materials:

accurately weighing maltodextrin and licorice clear paste, wherein the mass ratio of the maltodextrin to the licorice clear paste is 2.7: 1, standby.

1.3 Total mix (paste powder):

gradually adding the licorice root clear paste and maltodextrin into a traditional Chinese medicine clear paste spray dryer according to a small amount of times, setting the temperature at 180 ℃, controlling the air inlet temperature at 175-185 ℃, the air outlet temperature at 85-95 ℃, and setting the negative pressure in a tower at-8 to-12 Pa, fully mixing the licorice root clear paste and maltodextrin, stirring, collecting dry licorice root extract powder at regular time, crushing the dry licorice root extract powder, sieving by a sieve of 80-100 meshes, adding a proper amount of 0.5 percent of magnesium stearate, placing the mixture in a mixing tank, and mixing for 20-40 minutes.

1.4 dry granulation:

granulating dry licorice powder by using a dry granulator, sieving the dry licorice powder by 80-100 meshes, pouring the dry licorice powder onto the dry granulator, sieving coarse particles and fine particles by using 20-40 mesh sieves respectively, adding the coarse particles and the fine particles into the granulator again for granulation, and finally obtaining the licorice granules with the particle size of 20-40 meshes, uniform particle color, and the particle size of the granules which can not pass through the sum of a No. one sieve (10 meshes) and a No. five sieve (80 meshes) and can not exceed 15%, and warehousing after the examination is qualified.

1.5 particle:

and (4) inspecting the licorice granules obtained in the step (1.4), wherein the licorice granules are required to meet relevant regulations of quality standards of licorice formula granules, and the moisture, the granularity and the dissolubility are required to meet the regulations.

1.6, subpackaging:

and (4) subpackaging the licorice granules obtained in the step (1.4), taking a stainless steel measuring cup of a corresponding model according to the filling specification, and checking whether the measuring cup has a groove, a curled edge, a unfilled corner and abrasion. The filling is firstly carried out before filling, the filling amount difference of each measuring cup is checked, the filling amount is adjusted according to the weight of each bag, the operation is carried out according to the operation regulations of 'granule filling SOP' and granule subpackaging post, and the machine is started up formally (the production speed is 60-80 bags/min; the temperature of a longitudinal sealing roller is 100-210 ℃ and the temperature of a transverse sealing roller is 120-220 ℃) after meeting the requirements. The average bag weight was checked every 20 minutes after start-up. In the filling process, the filling amount difference and the sealing performance are controlled, and the sampling result is recorded, so that the filling amount of each bag is ensured to be in a control range. The bagged particles are put into a special container. Each bag contains 0.5g of raw medicinal materials, which is equivalent to 3 g. According to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; placing a product certificate in the outer box, sealing with sealing tape, bundling firmly, sealing, and packaging into corrugated paper box.

Example 4

The objective of this embodiment is to provide a licorice granule, the flow is shown in fig. 1, wherein the shaded square blocks represent the clean zone, i.e. the aseptic zone, and the unshaded square blocks represent the general working zone, comprising the following steps:

1.1 extraction and concentration:

carefully selecting impurity-free and high-quality liquorice pieces, accurately weighing 6000g of liquorice pieces, putting into an extraction tank, adding drinking water into the extraction tank, decocting twice, keeping the temperature of the water at 90-100 ℃ and decocting for 2.5 hours, wherein the mass of the drinking water added for the first time is 8.3 times of that of the liquorice pieces, heating the water in the extraction tank to boil, and filtering the liquid medicine after the first decoction is finished to leave dregs.

Adding drinking water 6.5 times the weight of Glycyrrhrizae radix decoction pieces into the residue, heating to boil, decocting for 1 hr, filtering the second decoction, mixing with the first decoction, pumping the mixed filtrate into a medicinal liquid storage tank, standing for 3-3.5 hr or more; filtering out supernatant obtained by standing, transferring into a vacuum concentration tank, operating according to the operating specification of the vacuum concentrator, opening a steam valve, vacuum concentrating to obtain fluid extract with relative density of 1.08-1.20 and temperature of 60 ℃, passing through a 180-mesh and 200-mesh sieve while hot to obtain Glycyrrhrizae radix fluid extract, and temporarily storing in a fluid extract storage tank.

1.2, preparing materials:

accurately weighing maltodextrin and licorice clear paste, wherein the mass ratio of the maltodextrin to the licorice clear paste is 2.8: 1, standby.

1.3 Total mix (paste powder):

gradually adding the licorice root clear paste and maltodextrin into a traditional Chinese medicine clear paste spray dryer according to a small amount of times, setting the temperature at 180 ℃, controlling the air inlet temperature at 175-185 ℃, the air outlet temperature at 85-95 ℃, and setting the negative pressure in a tower at-8 to-12 Pa, fully mixing the licorice root clear paste and maltodextrin, stirring, collecting dry licorice root extract powder at regular time, crushing the dry licorice root extract powder, sieving by a sieve of 80-100 meshes, adding a proper amount of 0.5 percent of magnesium stearate, placing the mixture in a mixing tank, and mixing for 20-40 minutes.

1.4 granulating:

granulating dry licorice powder by using a dry granulator, sieving the dry licorice powder by 80-100 meshes, pouring the dry licorice powder onto the dry granulator, sieving coarse particles and fine particles by using 20-40 mesh sieves respectively, adding the coarse particles and the fine particles into the granulator again for granulation, and finally obtaining the licorice granules with the particle size of 20-40 meshes, uniform particle color, and the particle size of the granules which can not pass through the sum of a No. one sieve (10 meshes) and a No. five sieve (80 meshes) and can not exceed 15%, and warehousing after the examination is qualified.

1.5 particle:

and (4) inspecting the licorice granules obtained in the step (1.4), wherein the licorice granules are required to meet relevant regulations of quality standards of licorice formula granules, and the moisture, the granularity and the dissolubility are required to meet the regulations.

1.6, subpackaging:

and (4) subpackaging the licorice granules obtained in the step (1.4), taking a stainless steel measuring cup of a corresponding model according to the filling specification, and checking whether the measuring cup has a groove, a curled edge, a unfilled corner and abrasion. The filling is firstly carried out before filling, the filling amount difference of each measuring cup is checked, the filling amount is adjusted according to the weight of each bag, the operation is carried out according to the operation regulations of 'granule filling SOP' and granule subpackaging post, and the machine is started up formally (the production speed is 60-80 bags/min; the temperature of a longitudinal sealing roller is 100-210 ℃ and the temperature of a transverse sealing roller is 120-220 ℃) after meeting the requirements. The average bag weight was checked every 20 minutes after start-up. In the filling process, the filling amount difference and the sealing performance are controlled, and the sampling result is recorded, so that the filling amount of each bag is ensured to be in a control range. The bagged particles are put into a special container. Each bag contains 0.5g of raw medicinal materials, which is equivalent to 3 g. According to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; placing a product certificate in the outer box, sealing with sealing tape, bundling firmly, sealing, and packaging into corrugated paper box.

Example 5

The objective of this embodiment is to provide a licorice granule, the flow is shown in fig. 1, wherein the shaded square blocks represent the clean zone, i.e. the aseptic zone, and the unshaded square blocks represent the general working zone, comprising the following steps:

1.1 extraction and concentration:

carefully selecting impurity-free and high-quality liquorice pieces, accurately weighing 6000g of liquorice pieces, putting into an extraction tank, adding drinking water into the extraction tank, decocting twice, keeping the temperature of the water at 90-100 ℃ and decocting for 2 hours, wherein the mass of the drinking water added for the first time is 8.2 times of that of the liquorice pieces, heating the water in the extraction tank to boil, and filtering the liquid medicine after the first decoction is finished to leave dregs of a decoction.

Adding drinking water 6.4 times the weight of the liquorice decoction pieces into the dregs of a decoction, heating to boil, decocting for 1 hour, filtering out the liquid medicine of the second time after the second time of decoction is finished, combining the liquid medicine with the filtrate obtained by the first time of decoction, pumping the combined filtrate into a liquid medicine storage tank, and standing for more than 3-3.5 hours; filtering out supernatant obtained by standing, transferring into a vacuum concentration tank, operating according to the operating specification of the vacuum concentrator, opening a steam valve, vacuum concentrating to obtain fluid extract with relative density of 1.08-1.20 and temperature of 80 ℃, passing through a 180-mesh and 200-mesh sieve while hot to obtain Glycyrrhrizae radix fluid extract, and temporarily storing in a fluid extract storage tank.

1.2, preparing materials:

accurately weighing maltodextrin and licorice clear paste, wherein the mass ratio of the maltodextrin to the licorice clear paste is 2.9: 1, standby.

1.3 Total mix (paste powder):

gradually adding the licorice root clear paste and maltodextrin into a traditional Chinese medicine clear paste spray dryer according to a small amount of times, setting the temperature at 180 ℃, controlling the air inlet temperature at 175-185 ℃, the air outlet temperature at 85-95 ℃, and setting the negative pressure in a tower at-8 to-12 Pa, fully mixing the licorice root clear paste and maltodextrin, stirring, collecting dry licorice root extract powder at regular time, crushing the dry licorice root extract powder, sieving by a sieve of 80-100 meshes, adding a proper amount of 0.5 percent of magnesium stearate, placing the mixture in a mixing tank, and mixing for 20-40 minutes.

1.4 dry granulation:

granulating dry licorice powder by using a dry granulator, sieving the dry licorice powder by 80-100 meshes, pouring the dry licorice powder onto the dry granulator, sieving coarse particles and fine particles by using 20-40 mesh sieves respectively, adding the coarse particles and the fine particles into the granulator again for granulation, finally obtaining particles with the particle size of 20-40 meshes, wherein the particles are uniform in color and luster, checking the particle size of the particles, and determining the particles to be the licorice particles after the particles are qualified by checking, wherein the particles cannot pass through the sum of the first sieve and the fifth sieve and cannot exceed 15%.

1.5 particle:

and (4) inspecting the licorice granules obtained in the step (1.4), wherein the licorice granules are required to meet relevant regulations of quality standards of licorice formula granules, and the moisture, the granularity and the dissolubility are required to meet the regulations.

1.6, subpackaging:

and (4) subpackaging the licorice granules obtained in the step (1.4), taking a stainless steel measuring cup of a corresponding model according to the filling specification, and checking whether the measuring cup has a groove, a curled edge, a unfilled corner and abrasion. The filling is firstly carried out before filling, the filling amount difference of each measuring cup is checked, the filling amount is adjusted according to the weight of each bag, the operation is carried out according to the operation regulations of 'granule filling SOP' and granule subpackaging post, and the machine is started up formally (the production speed is 60-80 bags/min; the temperature of a longitudinal sealing roller is 100-210 ℃ and the temperature of a transverse sealing roller is 120-220 ℃) after meeting the requirements. The average bag weight was checked every 20 minutes after start-up. In the filling process, the filling amount difference and the sealing performance are controlled, and the sampling result is recorded, so that the filling amount of each bag is ensured to be in a control range. The bagged particles are put into a special container. Each bag contains 0.5g of raw medicinal materials, which is equivalent to 3 g. According to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; placing a product certificate in the outer box, sealing with sealing tape, bundling firmly, sealing, and packaging into corrugated paper box.

Example 6

The objective of this embodiment is to provide a licorice granule, the flow is shown in fig. 1, wherein the shaded square blocks represent the clean zone, i.e. the aseptic zone, and the unshaded square blocks represent the general working zone, comprising the following steps:

1.1 extraction and concentration:

carefully selecting impurity-free and high-quality liquorice pieces, accurately weighing 6000g of liquorice pieces, putting into an extraction tank, adding drinking water into the extraction tank, decocting twice, keeping the temperature of the water at 90-100 ℃ and decocting for 2.5 hours, heating the water in the extraction tank to boil, and filtering the liquid medicine after the first decoction to leave dregs.

Adding drinking water 6.5 times the weight of Glycyrrhrizae radix decoction pieces into the residue, heating to boil, decocting for 1 hr, filtering the second decoction, mixing with the first decoction, pumping the mixed filtrate into a medicinal liquid storage tank, standing for 3-3.5 hr or more; filtering out supernatant obtained by standing, transferring into a vacuum concentration tank, operating according to the operating specification of the vacuum concentrator, opening a steam valve, vacuum concentrating to obtain fluid extract with relative density of 1.08-1.20 and temperature of 70 ℃, passing through a 180-mesh and 200-mesh sieve while hot to obtain Glycyrrhrizae radix fluid extract, and temporarily storing in a fluid extract storage tank.

1.2, preparing materials:

accurately weighing maltodextrin and licorice clear paste, wherein the mass ratio of the maltodextrin to the licorice clear paste is 2.7: 1, standby.

1.3 Total mix (paste powder):

gradually adding the licorice root clear paste and maltodextrin into a traditional Chinese medicine clear paste spray dryer according to a small amount of times, setting the temperature at 180 ℃, controlling the air inlet temperature at 175-185 ℃, the air outlet temperature at 85-95 ℃, and setting the negative pressure in a tower at-8 to-12 Pa, fully mixing the licorice root clear paste and maltodextrin, stirring, collecting dry licorice root extract powder at regular time, crushing the dry licorice root extract powder, sieving the crushed dry licorice root extract powder by a sieve of 80-100 meshes, and placing the powder in a mixing tank for mixing for 20-30 minutes.

1.4 dry granulation:

granulating dry licorice powder by using a dry granulator, sieving the dry licorice powder by 80-100 meshes, pouring the dry licorice powder onto the dry granulator, sieving coarse particles and fine particles by using 20-40 mesh sieves respectively, adding the coarse particles and the fine particles into the granulator again for granulation, and finally obtaining the licorice granules with the particle size of 20-40 meshes, uniform particle color, and the particle size of the granules which can not pass through the sum of a No. one sieve (10 meshes) and a No. five sieve (80 meshes) and can not exceed 15%, and warehousing after the examination is qualified.

1.5 particle:

and (4) inspecting the licorice granules obtained in the step (1.4), wherein the licorice granules are required to meet relevant regulations of quality standards of licorice formula granules, and the moisture, the granularity and the dissolubility are required to meet the regulations.

1.6, subpackaging:

and (4) subpackaging the licorice granules obtained in the step (1.4), taking a stainless steel measuring cup of a corresponding model according to the filling specification, and checking whether the measuring cup has a groove, a curled edge, a unfilled corner and abrasion. The filling is firstly carried out before filling, the filling amount difference of each measuring cup is checked, the filling amount is adjusted according to the weight of each bag, the operation is carried out according to the operation regulations of 'granule filling SOP' and granule subpackaging post, and the machine is started up formally (the production speed is 60-80 bags/min; the temperature of a longitudinal sealing roller is 100-210 ℃ and the temperature of a transverse sealing roller is 120-220 ℃) after meeting the requirements. The average bag weight was checked every 20 minutes after start-up. In the filling process, the filling amount difference and the sealing performance are controlled, and the sampling result is recorded, so that the filling amount of each bag is ensured to be in a control range. The bagged particles are put into a special container. Each bag contains 0.5g of raw medicinal materials, which is equivalent to 3 g. According to the standard operation rules of the outer packing posts, in the packing procedure, a small box is packed, a large box is packed, an anti-counterfeiting trademark is pasted, a batch number is covered, and an outer box is packed; placing a product certificate in the outer box, sealing with sealing tape, bundling firmly, sealing, and packaging into corrugated paper box.

The drying temperatures in examples 1 to 6 were set at 180 ℃ and the temperatures were set at 175 to 185 ℃, preferably 180 ℃. In the preliminary test, 3g, 5g and 8g of liquorice formula granules with drying temperatures of 175 ℃, 180 ℃ and 185 ℃ respectively are taken, the moisture content of the granules is measured by a moisture measuring instrument, and the moisture content condition of the granules is recorded. The test results are shown in Table 1, which shows that the water content of the granules is 5-6% at a drying temperature of 180 ℃, the fluctuation is minimal, and the licorice formulation granules can be well stored. The drying temperature was thus determined to be 180 ℃.

TABLE 1 moisture content fluctuation of the granulate

Performing sensory identification on the licorice granules provided in the embodiments 1 to 6, wherein the licorice granules are light brown yellow granules with uniform color and size; slightly fragrant smell and sweet taste. Liquid chromatography detection shows that the licorice particles provided by the embodiment of the invention contain a large amount of beneficial components such as glycyrrhizic acid and liquiritin, wherein the glycyrrhizic acid is between 2.60% and 2.69%, and the liquiritin is between 1.80% and 1.93%, compared with the glycyrrhizic acid content of 2.32% to 2.38% and the liquiritin content of 1.81% to 1.87% in the original decoction piece decoction, the liquiritin component contained in the licorice particles is equivalent to the liquiritin beneficial component in the original decoction piece, and the glycyrrhizic acid component is slightly higher than the glycyrrhizic acid content in the original decoction piece, which is shown in table 2 specifically.

TABLE 2 comparison of glycyrrhizic acid and glycyrrhizin in Licorice decoction pieces and Licorice granule

In summary, according to the preparation method of licorice granules provided by the embodiment of the present invention, through specific extraction and concentration processes, beneficial ingredients in licorice are fully retained, raw materials are more uniformly mixed by a high-speed mixing granulator, and then the concentrated fluid extract is dried and granulated by using a dry spraying method, so that unqualified granules with wide granules are greatly reduced, and the yield is improved. Compared with the traditional Chinese medicine decoction, the liquorice particles prepared by the preparation method of the liquorice particles provided by the invention not only save the decoction time of medicinal materials, but also keep the property of the original medicinal materials, are convenient to carry and can be eaten at any time, and the dosage of a large amount of beneficial components is smaller, so that the liquorice particles are more suitable for the fast-paced life of modern people.

The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.