阅读说明：本技术 治疗子宫内膜异位症的止痛消癥散结中药及其制作方法 (Pain-relieving and stasis-eliminating traditional Chinese medicine for treating endometriosis and preparation method thereof ) 是由 夏敏 刘恒炼 王彩霞 于 2021-08-20 设计创作，主要内容包括：本发明公开了一种医药技术领域的治疗子宫内膜异位症的止痛症散结中药及其制作方法,包括的药物有熟大黄、水蛭、制香附、桂枝、艾叶、乌药、延胡索和三七；将药物制成胶囊进行服用；本发明相较于现有技术的有益效果为能够有效的对子宫内膜异位症引起的疼痛、包块、月经失调、不孕进行治疗,并且疗效明显确切,副作用小。(The invention discloses an analgesic stasis-removing traditional Chinese medicine for treating endometriosis and a preparation method thereof, belonging to the technical field of medicines, and the traditional Chinese medicine comprises cooked rhubarb, leech, prepared rhizoma cyperi, cassia twig, folium artemisiae argyi, radix linderae, rhizoma corydalis and pseudo-ginseng; the medicine is prepared into capsules for taking; compared with the prior art, the traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition can effectively treat pain, mass, menstrual disorder and infertility caused by endometriosis, and has obvious and definite curative effect and small side effect.)

1. An analgesic stasis-removing traditional Chinese medicine for treating endometriosis is characterized by comprising the following components in parts by weight: 8-10 parts of cooked rhubarb, 2-4 parts of leech, 5-7 parts of prepared rhizoma cyperi, 9-11 parts of cassia twig, 9-12 parts of folium artemisiae argyi, 9-11 parts of radix linderae, 14-17 parts of rhizoma corydalis and 5-7 parts of pseudo-ginseng.

2. The analgesic stasis-resolving traditional Chinese medicine for treating endometriosis according to claim 1, which is characterized in that: the weight components of the medicine are as follows: 9 parts of cooked rhubarb, 3 parts of leech, 6 parts of prepared rhizoma cyperi, 10 parts of cassia twig, 10 parts of folium artemisiae argyi, 10 parts of radix linderae, 15 parts of rhizoma corydalis and 6 parts of pseudo-ginseng.

3. The analgesic stasis-resolving traditional Chinese medicine for treating endometriosis according to claim 1, which is characterized in that: mixing radix et rhizoma Rhei preparata, Hirudo, rhizoma Cyperi preparata, ramulus Cinnamomi, folium Artemisiae Argyi, radix Linderae, rhizoma corydalis and Notoginseng radix, and making into capsule for administration.

4. The method for preparing an analgesic stasis-dissipating traditional Chinese medicine for treating endometriosis according to claim 1, is characterized in that: the method comprises the following steps:

001. firstly, performing sand scalding on leeches to prepare powder, then preparing pseudo-ginseng into powder, and respectively placing the powdered leeches and pseudo-ginseng aside for later use;

002. mixing radix et rhizoma Rhei preparata, rhizoma Cyperi preparata, ramulus Cinnamomi, folium Artemisiae Argyi, radix Linderae, and rhizoma corydalis, adding 10 times of clear water, decocting for 1 hr, and filtering to obtain medicinal liquid;

003. adding clear water with the weight 8 times of the total weight of the mixed medicines into the medicine dregs in the step 002, decocting for 1 hour, and filtering out liquid medicine for later use;

004. mixing the liquid medicines in the steps 002 and 003, and concentrating the obtained mixed liquid medicine into a thick paste for later use;

005. adding the leech powder and the pseudo-ginseng powder in the step 001 into the thick paste in the step 004, and stirring and mixing;

006. drying the thick paste completely mixed in the step 005, then crushing into powder, and filling into capsules.

5. The method for preparing an analgesic stasis-dissipating traditional Chinese medicine for treating endometriosis according to claim 4, is characterized in that: the concentration in the step 004 can be realized by modern mechanical concentration or slow boiling concentration with small fire.

6. The method for preparing an analgesic stasis-dissipating traditional Chinese medicine for treating endometriosis according to claim 4, is characterized in that: the decocting in the steps 002 and 003 is carried out by boiling with strong fire and then decocting with slow fire for 1 hour.

Technical Field

The invention relates to the technical field of medicines, in particular to a traditional Chinese medicine for treating endometriosis and relieving pain, eliminating mass and dissipating binds and a preparation method thereof.

Background

Endometriosis is a growing endometrial tissue, including glands and interstitium, that occurs in other parts of the body than the lining mucosa of the uterine cavity. The symptoms of dysmenorrheal, persistent abdominal pain, menstrual disorder, infertility, dyspareunia and the like are often caused, and due to the planting behavior, multiple organs of the whole body can be affected to form various nodules and masses, so that the serious pain affects sleeping, working and learning, the infertility can affect family stability, and the masses break, twist and even cause acute abdominal diseases. At present, most methods for treating endometriosis are operations, GnRH medicine injection, intrauterine device placement and the like, although the operations can solve the problem of mass formed by endometriosis, the curative effects on pain relieving and infertility are not ideal, and especially the effect on patients with unobvious focuses is not good enough; the injected GnRH medicine can play a role in inhibiting focus in a short time, but the disease relapse is more obvious after the treatment is stopped; the intrauterine device is suitable for patients with the fertility-free requirement; therefore, the above treatments have disadvantages and cannot be used for a long time for patients with fertility requirements. There are also a number of Chinese patent medicines in the market for relieving pain and eliminating mass, but no medicine specially aiming at endometriosis exists, and the curative effect on symptoms of endometriosis is poor.

In conclusion, the inventor provides the traditional Chinese medicine for treating endometriosis, relieving pain, eliminating symptoms and dissipating stagnation and the preparation method thereof.

Disclosure of Invention

The technical problem to be solved by the technical scheme of the invention is to treat the pain, mass, menstrual disorder and infertility of endometriosis, and in order to achieve the aim, the invention provides a traditional Chinese medicine for relieving pain, eliminating mass and dissipating stagnation and treating endometriosis and a preparation method thereof.

An analgesic stasis-removing traditional Chinese medicine for treating endometriosis comprises the following components in parts by weight: 8-10 parts of cooked rhubarb, 2-4 parts of leech, 5-7 parts of prepared rhizoma cyperi, 9-11 parts of cassia twig, 9-12 parts of folium artemisiae argyi, 9-11 parts of radix linderae, 14-17 parts of rhizoma corydalis and 5-7 parts of pseudo-ginseng; in the components of the invention, various medicinal materials have the following beneficial effects:

the cooked rhubarb mainly removes blood stasis, stops cold and heat, breaks illness, accumulates, remains food, washes intestines and stomach, promotes old to cause novelty, cools blood and detoxifies, promotes diuresis, regulates middle energizer and digests food, calms and harmonizes five internal organs; modern pharmacological research shows that the rhizome of rhubarb contains various bioactive components, and at least 25 elements exist in the inorganic component. Namely anthracene derivatives, stilbene compounds, tannins, organic acids, volatile oils and the like. Radix et rhizoma Rhei has effects of stopping bleeding, removing blood stasis, and removing blood stasis.

The leech can break blood, remove stasis and eliminate mass, and can be used for eliminating mass, and pharmacological research suggests that the leech contains heparin and antithrombotic agent and has an anticoagulation effect;

the rhizoma cyperi has the effects of soothing the liver, regulating the flow of qi, regulating menstruation and relieving pain, and pharmacological research can relieve the contraction force and tension of uterine smooth muscle; has inhibitory effect on Staphylococcus aureus and partial fungi.

Cassia twig has the functions of warming and dredging meridian and invigorating yang and regulating qi, and may be used in treating diseases, such as abdominal mass, arthralgia, etc. modern pharmacological research shows that it has several pathogenic bacteria inhibiting effect, tranquilizing, pain relieving and convulsion relieving effect.

The folium artemisiae argyi has the effects of warming meridians, warming uterus, stopping bleeding, dispelling cold and regulating menstruation, and has the effects of exciting uterus and inhibiting various pathogenic bacteria and fungi in pharmacological research;

wu Yao warms kidney to dispel cold, promotes qi circulation to alleviate pain. Can be used for treating cold accumulation, qi stagnation, and pain, and has bidirectional regulating effect on smooth muscle.

Rhizoma corydalis has effects of promoting blood circulation, activating qi-flowing and relieving pain, is used for pain symptoms caused by qi and blood stasis, is used for treating various spastic and non-spastic pains of internal organs at present, and has effects of tranquilizing, hypnotizing and calming in pharmacological research.

Notoginseng radix has effects of promoting blood circulation, relieving pain, removing blood stasis and stopping bleeding, and can be used for treating pain due to blood stasis. Modern pharmacological research shows that the product has tranquilizing, analgesic, and anti-inflammatory effects, and also has antiaging and antitumor effects.

Further limited, the specific weight components of the medicine are as follows: 9 parts of cooked rhubarb, 3 parts of leech, 6 parts of prepared rhizoma cyperi, 10 parts of cassia twig, 10 parts of folium artemisiae argyi, 10 parts of radix linderae, 15 parts of rhizoma corydalis and 6 parts of pseudo-ginseng; the medicament of the proportion has better treatment effect.

Further limiting, mixing radix et rhizoma Rhei preparata, Hirudo, rhizoma Cyperi preparata, ramulus Cinnamomi, folium Artemisiae Argyi, radix Linderae, rhizoma corydalis and Notoginseng radix, and making into capsule for administration; the medicine is mixed to prepare the capsule, so that the taking effect is better, the medicine can be ensured not to be attached to the esophagus when being swallowed, and the treatment effect is improved.

Further limited, a preparation method of the traditional Chinese medicine formula for treating endometriosis with the functions of relieving pain and dissipating binds, which comprises the following steps:

001. firstly, performing sand scalding on leeches to prepare powder, then preparing pseudo-ginseng into powder, and respectively placing the powdered leeches and pseudo-ginseng aside for later use;

002. mixing radix et rhizoma Rhei preparata, rhizoma Cyperi preparata, ramulus Cinnamomi, folium Artemisiae Argyi, radix Linderae, and rhizoma corydalis, adding 10 times of clear water, decocting for 1 hr, and filtering to obtain medicinal liquid;

003. adding clear water with the weight 8 times of the total weight of the mixed medicines into the medicine dregs in the step 002, decocting for 1 hour, and filtering out liquid medicine for later use;

004. mixing the liquid medicines in the steps 002 and 003, and concentrating the obtained mixed liquid medicine into a thick paste for later use;

005. adding the leech powder and the pseudo-ginseng powder in the step 001 into the thick paste in the step 004, and stirring and mixing;

006. drying the thick paste completely mixed in the step 005, then crushing into powder, and filling into capsules.

Further limiting, the concentration in the step 004 can be realized by adopting modern mechanical concentration or slow boiling concentration with small fire; the concentration mode can be selected according to actual conditions.

Further limiting, the decocting in the steps 002 and 003 is firstly boiling with strong fire and then decocting with slow fire for 1 hour; the required effect can be achieved under the condition of ensuring the efficiency by boiling with big fire and then decocting with small fire.

Compared with the prior art, the traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition can effectively treat pain, mass, menstrual disorder and infertility caused by endometriosis, and has obvious and definite curative effect and small side effect.

Drawings

FIG. 1 is a symptom hierarchy table.

Detailed Description

In order that those skilled in the art can better understand the technical solution of the present invention, the following embodiments are further described with reference to the accompanying drawings and examples.

Example 1:

an analgesic stasis-removing traditional Chinese medicine for treating endometriosis comprises the following components in parts by weight: 9 g of cooked rhubarb, 3 g of leech, 6 g of prepared nutgrass galingale rhizome, 10g of cassia twig, 10g of argy wormwood leaf, 10g of combined spicebush root, 15 g of corydalis tuber and 6 g of pseudo-ginseng;

a preparation method of an analgesic stasis-removing traditional Chinese medicine formula for treating endometriosis comprises the following preparation steps:

001. firstly, performing sand scalding on leeches to prepare powder, then preparing pseudo-ginseng into powder, and respectively placing the powdered leeches and pseudo-ginseng aside for later use;

002. mixing radix et rhizoma Rhei preparata, rhizoma Cyperi preparata, ramulus Cinnamomi, folium Artemisiae Argyi, radix Linderae, and rhizoma corydalis, adding 690 g of clear water, decocting for 1 hr, and filtering to obtain medicinal liquid;

003. adding 552 g of clear water of the total weight of the mixed medicines into the medicine dregs in the step 002, decocting for 1 hour, and filtering out liquid medicine for later use;

004. mixing the liquid medicines in the steps 002 and 003, and then decocting the obtained mixed liquid medicine with slow fire for a long time to concentrate the mixed liquid medicine into thick paste for later use;

005. adding the leech powder and the pseudo-ginseng powder in the step 001 into the thick paste in the step 004, and stirring and mixing;

006. drying the thick paste completely mixed in the step 005, then crushing into powder, and filling into capsules.

When the capsule is taken by a patient, 0.5g of the capsule is orally taken, 4 capsules are taken each time, and the dosage is 3 times a day.

The main manifestations of the application of the technical proposal of the invention in treating dysmenorrheal, persistent hypogastric pain, menstrual disorder, infertility, dyspareunia and the like caused by endometriosis are 80 cases (including 40 cases of a control group), the curative effect and the side effect are considered, and the observed results are summarized as follows:

general clinical data:

80 cases of the group are all from outpatients of emergency department in hospital, 40 cases of the treatment group and the control group respectively,

treatment groups: women 40, 14-49 (34.8 + -8.9) years of age, 9 mild, 22 moderate, and 9 severe.

Control group: women 40, ages 16-48 (36.4 + -10.2), mild 10, moderate 24, and severe 6.

According to the condition, the patients have catarrhal symptoms, which are mainly manifested as dysmenorrhea, persistent abdominal pain, menstrual disorder, infertility and dyspareunia.

Other medicines or externally applied medicines are not taken before treatment.

The diagnosis method comprises the following steps:

(1) disease diagnosis standard conditions: the traditional Chinese medicine diagnosis standard is as follows: refer to the Chinese medicine gynecological clinical research (Shuitangzhou Shuihu, edited by Xiao-Tuo, national institute of health and human, 2009) which is a research and development planning material in higher Chinese medical institutions in China. Western diagnostic criteria: refer to "clinical guide-gynecology and obstetrics brochure" (edited by the Chinese medical society, public health Press, 2009.)

(2) Disease diagnosis symptom grading:

physical signs: the uterus is usually in the posterior position, the activity is limited or the uterus is fixed by adhesion, and the uterus can have tenderness when the uterus is myositis; if the disease is salpingitis, the thick oviduct is touched on one side or two sides of the uterus and has tenderness; if the uterine tube hydrops or the uterine tube ovarian cyst is detected, cystic masses touch one side or two sides of the pelvic cavity, the movement is more limited, and the uterine tube hydrops or the uterine tube ovarian cyst can cause tenderness; in case of pelvic connective tissue inflammation, there is a thickening and tenderness of the slice on one or both sides of the uterus, or a thickening, stiffening and tenderness of the uterosacral ligaments.

Grading standard of disease condition degree

And (4) integrating the scores of the symptoms and the signs to judge the disease degree.

Mild: the score of symptoms and signs is 10-18.

Medium: symptoms, signs integration and 19-27 points.

And (3) severe degree: the sum of the integral of symptoms and signs is more than or equal to 28 points.

(3) The medication method comprises the following steps:

the treatment group used the product of the invention, 0.5g per pill, 3 times a day, 4 pills each time. After the menstruation is cleared, the medicine is taken until the menstrual period stops. One menstrual cycle is a treatment course, three menstrual cycles are continuously treated, and contraception is performed during the treatment period. The control group orally takes the Dan e Fukang decoction ointment 10g each time and 3 times a day, and the Dan e Fukang decoction ointment is taken after cleaning until menstrual period stopping. One menstrual cycle is a treatment course, three menstrual cycles are continuously treated, and contraception is performed during the treatment period.

(4) The course of treatment is as follows: the treatment group and the control group were administered for 3 months.

(5) The study controls variables and ensures that patients can only use the product of the invention and the contrast drug.

3. Determination of therapeutic effect

3.1 comprehensive therapeutic effect judgment standard: refer to the clinical guiding principle of new Chinese medicine for treating pelvic endometriosis and the clinical guiding principle of new Chinese medicine for treating dysmenorrhea in the clinical research guiding principle of new Chinese medicine.

The clinical cure is as follows: the pain symptoms all disappeared;

the effect is shown: the pain is obviously reduced, and the integral of the pain symptom is reduced by more than 1/2;

the method has the following advantages: the pain is relieved compared with that before treatment, but still obvious pain is felt, and the integral of the pain symptom is reduced by 1/4-1/2;

and (4) invalidation: pain did not change or worsen significantly from before treatment and the score of symptoms decreased less than 1/4 or worsened.

3.2 the pain self-evaluation curative effect judgment standard of the patient: with reference to the world health organization: "visual analogue rating Scale for pain (VAS) oral rating Scale for pain (VRS)".

The clinical cure is as follows: the VAS and VRS integrals are both 0;

the effect is shown: the VAS and VRS integral is reduced by more than 1/2;

the method has the following advantages: the VAS and VRS integral is reduced by 1/4-1/2;

and (4) invalidation: the VAS, VRS integral reduction is under 1/4 or accentuated.

4. Results

The clinical efficacy of the two groups is compared as shown in the following table 2:

TABLE 2 therapeutic comparison

Grouping	Number of cases	Show effect	Is effective	Invalidation	Total effective rate
						Treatment group	40	14	22	4	90％
Control group	40	11	20	9	77.5％

There was no statistical difference in clinical efficacy between the treated and control groups (p < 0.05).

5. Side effect observation:

the common side effects of the drugs are observed, and none of the treatment groups has side effects, while the incidence rate of the control group is 10 percent, and the statistical difference is generated (p is less than 0.05). The following table 3 is specific:

TABLE 3 comparison of adverse effects

Grouping	Dizziness (lightheadedness)	Diarrhea (diarrhea)	Loss of appetite	Rash	Incidence rate
						Treatment group	0	1	0	1	5％
Control group	0	3	1	0	10％

The results show that: the product of the invention has better curative effect and less side effect on endometriosis compared with the traditional oral medicine.

Example 2:

the difference between the embodiment 2 and the embodiment 1 is that the weight of the medicine is 8 g of cooked rhubarb, 2 g of leech, 5g of prepared nutgrass galingale rhizome, 9 g of cassia twig, 9 g of argy wormwood leaf, 9 g of combined spicebush root, 14 g of corydalis tuber and 5g of pseudo-ginseng; the weight of the clean water taken in the step 002 is 610 g, the weight of the clean water taken in the step 003 is 488 g, and the capsules with 0.5g of each capsule are prepared in the same way.

Example 3:

example 3 is different from example 1 only in that the weight of the medicine is 10g of cooked rhubarb, 4 g of leech, 7 g of prepared nutgrass galingale rhizome, 11 g of cassia twig, 12 g of Chinese mugwort leaf, 11 g of combined spicebush root, 17 g of corydalis tuber and 7 g of pseudo-ginseng; the weight of the clean water obtained in the step 002 is 790 g, and the weight of the clean water obtained in the step 003 is 632 g.

Compared with the prior art, the traditional Chinese medicine composition has the beneficial effects that the traditional Chinese medicine composition can effectively treat pain, mass, menstrual disorder and infertility caused by endometriosis, and has obvious and definite curative effect and small side effect.

The above description of the specific embodiments of the pain-relieving mass-dissipating traditional Chinese medicine for treating endometriosis and the preparation method thereof is only provided to help understanding the method and the core concept of the invention. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.