阅读说明：本技术 用于仿生组织和生物组织的导电性测量的方法及系统 (Method and system for electrical conductivity measurement of biomimetic and biological tissues ) 是由 钱志勤 于至孚 顾慧君 张兵 章文俊 张春 于 2020-07-05 设计创作，主要内容包括：本发明公开了一种用于仿生组织和生物组织的导电性测量的方法,包括如下步骤：安装NI_VISA驱动程序,LabVIEW通过NI_VISA驱动程序调用底层系统资源,底层系统再通过仪器驱动实现对仪器设备的控制与数据交流；通过四电极测量探头获取数据；将第一通道采集的电压波形数据在计算机上显示,再根据LabVIEW界面上显示的波形图,通过编程读取电压波形数据的均方根值；将第二通道采集的电极II的电压波形数据在计算机上显示,再根据LabVIEW界面上显示的波形图,通过编程读取电极II的电压波形数据的均方根值；将第二通道采集的电极III的电压波形数据在计算机上显示,再根据LabVIEW界面上显示的波形图,通过编程读取电极III的电压波形数据的均方根值；基于公式求得仿生组织和生物组织的电导率。(The invention discloses a method for measuring the electrical conductivity of bionic tissues and biological tissues, which comprises the following steps: installing an NI-VISA driver, calling bottom system resources by LabVIEW through the NI-VISA driver, and realizing control and data communication of the instrument and the equipment by the bottom system through instrument driving; acquiring data through a four-electrode measuring probe; displaying the voltage waveform data acquired by the first channel on a computer, and reading the root mean square value of the voltage waveform data through programming according to a waveform diagram displayed on a LabVIEW interface; displaying the voltage waveform data of the electrode II acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode II through programming according to a waveform diagram displayed on a LabVIEW interface; displaying the voltage waveform data of the electrode III acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode III through programming according to a waveform diagram displayed on a LabVIEW interface; and (4) solving the electric conductivity of the bionic tissue and the biological tissue based on a formula.)

1. A method for electrical conductivity measurement of biomimetic and biological tissue, characterized by: the method for measuring the electrical conductivity of the bionic tissue and the biological tissue comprises the following steps:

installing an NI-VISA driver, calling bottom system resources by LabVIEW through the NI-VISA driver, and then realizing control and data communication of instrument equipment by the bottom system through instrument driving;

acquiring data through a four-electrode measuring probe, wherein the four probes of the four-electrode measuring probe are sequentially numbered as an electrode I, an electrode II, an electrode III and an electrode IV; the electrode I is connected with a signal input end, the electrode IV is connected with a current-voltage conversion probe, and the current-voltage conversion probe is connected with a first channel of an oscilloscope; the electrode II and the electrode III are connected with a second channel of the oscilloscope;

displaying the voltage waveform data acquired by the first channel on a computer, and reading the root mean square value of the voltage waveform data through programming according to a waveform diagram displayed on a LabVIEW interface;

displaying the voltage waveform data of the electrode II acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode II through programming according to a waveform diagram displayed on a LabVIEW interface;

Displaying the voltage waveform data of the electrode III acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode III through programming according to a waveform diagram displayed on a LabVIEW interface;

and (3) solving the electric conductivity of the bionic tissue and the biological tissue based on the following formula:

wherein σ is the electrical conductivity of the bionic tissue and the biological tissue, V₃Is the root mean square value, V, of the voltage waveform data of electrode III₂Is the root mean square value of the voltage waveform data of the electrode II, Vi is the root mean square value of the voltage waveform data, and K is the probe constant.

2. The method for electrical conductivity measurement of biomimetic and biological tissue according to claim 1, characterized in that: the method for measuring the electrical conductivity of the bionic tissue and the biological tissue comprises the following steps:

after finding the electrical conductivity of the biomimetic and biological tissues, the electrical conductivity of the biomimetic and biological tissues was stored in an Excel table.

3. The method for electrical conductivity measurement of biomimetic and biological tissue according to claim 2, characterized in that: the method for measuring the electrical conductivity of the bionic tissue and the biological tissue comprises the following steps:

after the root mean square value of the voltage waveform data of the electrode II and the electrode III is read, the electric conductivity of the bionic tissue and the biological tissue is obtained;

If the obtained electrical conductivity of the bionic tissue and the biological tissue is introduced into an Excel table, judging whether a numerical clearing event is triggered;

and if the numerical clearing event is judged to be triggered, clearing all read root mean square values of the voltage waveform data of the electrode II and the electrode III.

4. The method for electrical conductivity measurement of biomimetic and biological tissue according to claim 3, characterized in that: the method for measuring the electrical conductivity of the bionic tissue and the biological tissue comprises the following steps:

after clearing all the read root mean square values of the voltage waveform data of the electrode II and the electrode III, re-reading the root mean square values of the voltage waveform data of the electrode II and the voltage waveform data of the electrode III;

and calculating the electric conductivity of the bionic tissue and the biological tissue again based on the reread root mean square value of the voltage waveform data of the electrode II and the reread root mean square value of the voltage waveform data of the electrode III.

5. A system for electrical conductivity measurement of biomimetic and biological tissue, characterized by: the system stores a non-transitory computer-readable storage medium storing a computer program executable by a computer, the computer program, when executed, causing a processor to:

Installing an NI-VISA driver, calling bottom system resources by LabVIEW through the NI-VISA driver, and then realizing control and data communication of instrument equipment by the bottom system through instrument driving;

acquiring data through a four-electrode measuring probe, wherein the four probes of the four-electrode measuring probe are sequentially numbered as an electrode I, an electrode II, an electrode III and an electrode IV; the electrode I is connected with a signal input end, the electrode IV is connected with a current-voltage conversion probe, and the current-voltage conversion probe is connected with a first channel of an oscilloscope; the electrode II and the electrode III are connected with a second channel of the oscilloscope;

displaying the voltage waveform data acquired by the first channel on a computer, and reading the root mean square value of the voltage waveform data through programming according to a waveform diagram displayed on a LabVIEW interface;

displaying the voltage waveform data of the electrode II acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode II through programming according to a waveform diagram displayed on a LabVIEW interface;

displaying the voltage waveform data of the electrode III acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode III through programming according to a waveform diagram displayed on a LabVIEW interface;

And (3) solving the electric conductivity of the bionic tissue and the biological tissue based on the following formula:

wherein σ is the electrical conductivity of the bionic tissue and the biological tissue, V₃Is the root mean square value, V, of the voltage waveform data of electrode III₂Is the root mean square value of the voltage waveform data of the electrode II, Vi is the root mean square value of the voltage waveform data, and K is the probe constant.

6. The system for electrical conductivity measurement of biomimetic and biological tissue according to claim 5, wherein: the system stores a non-transitory computer-readable storage medium storing a computer program executable by a computer, the computer program, when executed, causing a processor to:

after finding the electrical conductivity of the biomimetic and biological tissues, the electrical conductivity of the biomimetic and biological tissues was stored in an Excel table.

7. The system for electrical conductivity measurement of biomimetic and biological tissue according to claim 6, wherein: the system stores a non-transitory computer-readable storage medium storing a computer program executable by a computer, the computer program, when executed, causing a processor to:

After the root mean square value of the voltage waveform data of the electrode II and the electrode III is read, the electric conductivity of the bionic tissue and the biological tissue is obtained;

if the obtained electrical conductivity of the bionic tissue and the biological tissue is introduced into an Excel table, judging whether a numerical clearing event is triggered;

and if the numerical clearing event is judged to be triggered, clearing all read root mean square values of the voltage waveform data of the electrode II and the electrode III.

8. The system for electrical conductivity measurement of biomimetic and biological tissue according to claim 7, wherein: the system stores a non-transitory computer-readable storage medium storing a computer program executable by a computer, the computer program, when executed, causing a processor to:

after clearing all the read root mean square values of the voltage waveform data of the electrode II and the electrode III, re-reading the root mean square values of the voltage waveform data of the electrode II and the voltage waveform data of the electrode III;

and calculating the electric conductivity of the bionic tissue and the biological tissue again based on the reread root mean square value of the voltage waveform data of the electrode II and the reread root mean square value of the voltage waveform data of the electrode III.

Technical Field

The invention relates to the technical field of biological tissue conductivity measurement, in particular to a method and a system for measuring the conductivity of bionic tissues and biological tissues.

Background

Measuring the conductivity of a material is not a difficult problem, and there are currently available devices on the market to measure the resistance, resistivity or impedance of the material, which are also well-established in the art. However, almost all current devices measure the conductivity under the condition of direct current, and the data has no reference value for the subject, because radio frequency ablation or microwave ablation adopts high-frequency alternating current, and under the condition of alternating current, the conductivity of the material can change greatly, and the biological tissue has the particularity of itself, so that a special method must be adopted for measuring. The prior art has proposed methods for measuring the conductivity of biological tissue using a four-electrode method.

The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.

Disclosure of Invention

It is an object of the present invention to provide a method and system for electrical conductivity measurement of biomimetic and biological tissue that overcomes the disadvantages of the prior art.

To achieve the above object, the present invention provides a method for measuring electrical conductivity of a biomimetic tissue and a biological tissue, comprising the steps of: installing an NI-VISA driver, calling bottom system resources by LabVIEW through the NI-VISA driver, and then realizing control and data communication of the instrument equipment by the bottom system through instrument driving; acquiring data through a four-electrode measuring probe, wherein the four probes of the four-electrode measuring probe are sequentially numbered as an electrode I, an electrode II, an electrode III and an electrode IV; the electrode I is connected with a signal input end, the electrode IV is connected with a current-voltage conversion probe, and the current-voltage conversion probe is connected with a first channel of the oscilloscope; wherein, the electrode II and the electrode III are connected with a second channel of the oscilloscope; displaying the voltage waveform data acquired by the first channel on a computer, and reading the root mean square value of the voltage waveform data through programming according to a waveform diagram displayed on a LabVIEW interface; displaying the voltage waveform data of the electrode II acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode II through programming according to a waveform diagram displayed on a LabVIEW interface; displaying the voltage waveform data of the electrode III acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode III through programming according to a waveform diagram displayed on a LabVIEW interface;

And (3) solving the electric conductivity of the bionic tissue and the biological tissue based on the following formula:

wherein σ is the electrical conductivity of the bionic tissue and the biological tissue, V₃Is the root mean square value, V, of the voltage waveform data of electrode III₂Is the root mean square value of the voltage waveform data of the electrode II, Vi is the root mean square value of the voltage waveform data, and K is the probe constant.

In a preferred embodiment, the method for electrical conductivity measurement of biomimetic and biological tissue comprises the steps of: after the electrical conductivities of the biomimetic and biological tissues were found, the electrical conductivities of the biomimetic and biological tissues were stored in an Excel table.

In a preferred embodiment, the method for electrical conductivity measurement of biomimetic and biological tissue comprises the steps of: after the root mean square value of the voltage waveform data of the electrode II and the electrode III is read, the electric conductivity of the bionic tissue and the biological tissue is obtained; if the obtained electrical conductivity of the bionic tissue and the biological tissue is introduced into an Excel table, judging whether a numerical clearing event is triggered; and if the trigger value clearing event is judged, clearing all read root mean square values of the voltage waveform data of the electrode II and the electrode III.

In a preferred embodiment, the method for electrical conductivity measurement of biomimetic and biological tissue comprises the steps of: after clearing all the read root mean square values of the voltage waveform data of the electrode II and the electrode III, re-reading the root mean square values of the voltage waveform data of the electrode II and the voltage waveform data of the electrode III; and calculating the electric conductivity of the bionic tissue and the biological tissue again based on the reread root mean square value of the voltage waveform data of the electrode II and the reread root mean square value of the voltage waveform data of the electrode III.

The invention also provides a system for electrical conductivity measurement of biomimetic and biological tissue, the system storing a non-transitory computer readable storage medium storing a computer program executable by a computer, the computer program when executed causing a processor to:

installing an NI-VISA driver, calling bottom system resources by LabVIEW through the NI-VISA driver, and then realizing control and data communication of the instrument equipment by the bottom system through instrument driving;

acquiring data through a four-electrode measuring probe, wherein the four probes of the four-electrode measuring probe are sequentially numbered as an electrode I, an electrode II, an electrode III and an electrode IV; the electrode I is connected with a signal input end, the electrode IV is connected with a current-voltage conversion probe, and the current-voltage conversion probe is connected with a first channel of an oscilloscope; wherein, the electrode II and the electrode III are connected with a second channel of the oscilloscope;

displaying the voltage waveform data acquired by the first channel on a computer, and reading the root mean square value of the voltage waveform data through programming according to a waveform diagram displayed on a LabVIEW interface;

displaying the voltage waveform data of the electrode II acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode II through programming according to a waveform diagram displayed on a LabVIEW interface;

Displaying the voltage waveform data of the electrode III acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode III through programming according to a waveform diagram displayed on a LabVIEW interface;

and (3) solving the electric conductivity of the bionic tissue and the biological tissue based on the following formula:

wherein σ is the electrical conductivity of the bionic tissue and the biological tissue, V₃Is the root mean square value, V, of the voltage waveform data of electrode III₂Is the root mean square value of the voltage waveform data of the electrode II, Vi is the root mean square value of the voltage waveform data, and K is the probe constant.

In a preferred embodiment, a system stores a non-transitory computer readable storage medium storing a computer program executable by a computer, the computer program when executed causing a processor to: after the electrical conductivities of the biomimetic and biological tissues were found, the electrical conductivities of the biomimetic and biological tissues were stored in an Excel table.

In a preferred embodiment, a system stores a non-transitory computer readable storage medium storing a computer program executable by a computer, the computer program when executed causing a processor to: after the root mean square value of the voltage waveform data of the electrode II and the electrode III is read, the electric conductivity of the bionic tissue and the biological tissue is obtained; if the obtained electrical conductivity of the bionic tissue and the biological tissue is introduced into an Excel table, judging whether a numerical clearing event is triggered; and if the trigger value clearing event is judged, clearing all read root mean square values of the voltage waveform data of the electrode II and the electrode III.

In a preferred embodiment, a system stores a non-transitory computer readable storage medium storing a computer program executable by a computer, the computer program when executed causing a processor to: after clearing all the read root mean square values of the voltage waveform data of the electrode II and the electrode III, re-reading the root mean square values of the voltage waveform data of the electrode II and the voltage waveform data of the electrode III; and calculating the electric conductivity of the bionic tissue and the biological tissue again based on the reread root mean square value of the voltage waveform data of the electrode II and the reread root mean square value of the voltage waveform data of the electrode III.

Compared with the prior art, the method and the system have the advantages that the method and the system have good noise resistance and anti-interference capability under the high-frequency condition, and the measurement error is reduced as much as possible. The system can measure the conductivity of the biological tissue and the bionic tissue under different frequencies, and provides important guarantee for subsequent various experiments.

Drawings

FIG. 1 is a flow diagram of a method according to an embodiment of the invention.

Detailed Description

The following detailed description of the present invention is provided in conjunction with the accompanying drawings, but it should be understood that the scope of the present invention is not limited to the specific embodiments.

Throughout the specification and claims, unless explicitly stated otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated element or component but not the exclusion of any other element or component.

FIG. 1 is a flow diagram of a method according to an embodiment of the invention. As shown in the figure, the method for measuring the electrical conductivity of the bionic tissue and the biological tissue comprises the following steps:

step 101: installing an NI-VISA driver, calling bottom system resources by LabVIEW through the NI-VISA driver, and then realizing control and data communication of the instrument equipment by the bottom system through instrument driving;

step 102: acquiring data through a four-electrode measuring probe, wherein the four probes of the four-electrode measuring probe are sequentially numbered as an electrode I, an electrode II, an electrode III and an electrode IV; the electrode I is connected with a signal input end, the electrode IV is connected with a current-voltage conversion probe, and the current-voltage conversion probe is connected with a first channel of the oscilloscope; wherein, the electrode II and the electrode III are connected with a second channel of the oscilloscope;

Step 103: displaying the voltage waveform data acquired by the first channel on a computer, and reading the root mean square value of the voltage waveform data through programming according to a waveform diagram displayed on a LabVIEW interface;

step 104: displaying the voltage waveform data of the electrode II acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode II through programming according to a waveform diagram displayed on a LabVIEW interface;

step 105: displaying the voltage waveform data of the electrode III acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode III through programming according to a waveform diagram displayed on a LabVIEW interface;

step 106: and (3) solving the electric conductivity of the bionic tissue and the biological tissue based on the following formula:

wherein σ is the electrical conductivity of the bionic tissue and the biological tissue, V₃Is the root mean square value, V, of the voltage waveform data of electrode III₂Is the root mean square value of the voltage waveform data of the electrode II, Vi is the root mean square value of the voltage waveform data, and K is the probe constant.

In a preferred embodiment, the method for electrical conductivity measurement of biomimetic and biological tissue comprises the steps of: after the electrical conductivities of the biomimetic and biological tissues were found, the electrical conductivities of the biomimetic and biological tissues were stored in an Excel table.

In a preferred embodiment, the method for electrical conductivity measurement of biomimetic and biological tissue comprises the steps of: after the root mean square value of the voltage waveform data of the electrode II and the electrode III is read, the electric conductivity of the bionic tissue and the biological tissue is obtained; if the obtained electrical conductivity of the bionic tissue and the biological tissue is introduced into an Excel table, judging whether a numerical clearing event is triggered; and if the trigger value clearing event is judged, clearing all read root mean square values of the voltage waveform data of the electrode II and the electrode III.

In a preferred embodiment, the method for electrical conductivity measurement of biomimetic and biological tissue comprises the steps of: after clearing all the read root mean square values of the voltage waveform data of the electrode II and the electrode III, re-reading the root mean square values of the voltage waveform data of the electrode II and the voltage waveform data of the electrode III; and calculating the electric conductivity of the bionic tissue and the biological tissue again based on the reread root mean square value of the voltage waveform data of the electrode II and the reread root mean square value of the voltage waveform data of the electrode III.

The invention also provides a system for electrical conductivity measurement of biomimetic and biological tissue, the system storing a non-transitory computer readable storage medium storing a computer program executable by a computer, the computer program when executed causing a processor to: installing an NI-VISA driver, calling bottom system resources by LabVIEW through the NI-VISA driver, and then realizing control and data communication of the instrument equipment by the bottom system through instrument driving; acquiring data through a four-electrode measuring probe, wherein the four probes of the four-electrode measuring probe are sequentially numbered as an electrode I, an electrode II, an electrode III and an electrode IV; the electrode I is connected with a signal input end, the electrode IV is connected with a current-voltage conversion probe, and the current-voltage conversion probe is connected with a first channel of the oscilloscope; wherein, the electrode II and the electrode III are connected with a second channel of the oscilloscope; displaying the voltage waveform data acquired by the first channel on a computer, and reading the root mean square value of the voltage waveform data through programming according to a waveform diagram displayed on a LabVIEW interface; displaying the voltage waveform data of the electrode II acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode II through programming according to a waveform diagram displayed on a LabVIEW interface; displaying the voltage waveform data of the electrode III acquired by the second channel on a computer, and reading the root mean square value of the voltage waveform data of the electrode III through programming according to a waveform diagram displayed on a LabVIEW interface; and (3) solving the electric conductivity of the bionic tissue and the biological tissue based on the following formula:

Wherein σ is the electrical conductivity of the bionic tissue and the biological tissue, V₃Is the root mean square value, V, of the voltage waveform data of electrode III₂Is the root mean square value of the voltage waveform data of the electrode II, Vi is the root mean square value of the voltage waveform data, and K is the probe constant.

In a preferred embodiment, a system stores a non-transitory computer readable storage medium storing a computer program executable by a computer, the computer program when executed causing a processor to: after the electrical conductivities of the biomimetic and biological tissues were found, the electrical conductivities of the biomimetic and biological tissues were stored in an Excel table.

In a preferred embodiment, a system stores a non-transitory computer readable storage medium storing a computer program executable by a computer, the computer program when executed causing a processor to: after the root mean square value of the voltage waveform data of the electrode II and the electrode III is read, the electric conductivity of the bionic tissue and the biological tissue is obtained; if the obtained electrical conductivity of the bionic tissue and the biological tissue is introduced into an Excel table, judging whether a numerical clearing event is triggered; and if the trigger value clearing event is judged, clearing all read root mean square values of the voltage waveform data of the electrode II and the electrode III.

In a preferred embodiment, a system stores a non-transitory computer readable storage medium storing a computer program executable by a computer, the computer program when executed causing a processor to: after clearing all the read root mean square values of the voltage waveform data of the electrode II and the electrode III, re-reading the root mean square values of the voltage waveform data of the electrode II and the voltage waveform data of the electrode III; and calculating the electric conductivity of the bionic tissue and the biological tissue again based on the reread root mean square value of the voltage waveform data of the electrode II and the reread root mean square value of the voltage waveform data of the electrode III.

The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.