阅读说明：本技术 化学发光免疫分析仪 (Chemiluminescence immunity analyzer ) 是由 罗刚银 林秋利 王鹏 林佳慧 杨意枫 于 2019-04-29 设计创作，主要内容包括：本发明公开了一种化学发光免疫分析仪,包括机架及设置在所述机架上的移液臂模块、试剂冷藏模块、样本和TIP供应模块、温育反应模块、废料仓模块；所述移液臂模块具有X方向和Z方向的自由度；所述试剂冷藏模块可旋转设置在所述机架上,用于对试剂进行冷藏；所述样本和TIP供应模块可在机架上进行Y方向的运动,用于提供一次性移液枪头、待测样本和试剂。本发明集移液、试剂冷藏、样本和TIP供应、温育反应、废料收集等功能于一体,能大大提高化学分析的效率和便捷性,具有很好的实际使用价值。本发明通过设置滑盖机构能实现在不开启盒体盖板的情况下完成样品的加入,从而能减小盒体盖板开启时对温育盒内部环境的干扰。(The invention discloses a chemiluminescence immunoassay analyzer, which comprises a rack, and a liquid-moving arm module, a reagent refrigeration module, a sample and TIP supply module, an incubation reaction module and a waste bin module which are arranged on the rack; the pipetting arm module has degrees of freedom in the X-direction and the Z-direction; the reagent refrigerating module is rotatably arranged on the rack and used for refrigerating the reagent; the sample and TIP supply module can move in the Y direction on the rack for providing the disposable pipette TIPs, the sample to be tested, and the reagents. The invention integrates the functions of liquid transfer, reagent refrigeration, sample and TIP supply, incubation reaction, waste collection and the like, can greatly improve the efficiency and convenience of chemical analysis, and has good practical use value. The invention can realize the addition of the sample under the condition of not opening the cover plate of the box body by arranging the sliding cover mechanism, thereby reducing the interference of the cover plate of the box body on the internal environment of the incubation box when opening.)

1. A chemiluminescence immunoassay analyzer is characterized by comprising a frame, a pipetting arm module, a reagent refrigerating module, a sample and TIP supplying module, an incubation reaction module and a waste bin module, wherein the pipetting arm module, the reagent refrigerating module, the sample and TIP supplying module, the incubation reaction module and the waste bin module are arranged on the frame;

Wherein the pipetting arm module has degrees of freedom in the X-direction and the Z-direction; the reagent refrigerating module is rotatably arranged on the rack and used for refrigerating the reagent; the sample and TIP supply module can move in the Y direction on the rack and is used for providing a disposable pipette TIP, a sample to be detected and a reagent; the incubation reaction module is used for carrying out incubation reaction and is provided with an electric cover opening mechanism.

2. The chemiluminescent immunoassay analyzer of claim 1, wherein the electric lid opening mechanism comprises a box cover plate arranged on the incubation box of the incubation reaction module, a support seat arranged on the side wall of the incubation box, a rotating shaft pivoted on the support seat, a worm wheel fixedly connected on the rotating shaft, an L-shaped connecting rod with a first end fixedly connected with the rotating shaft and a second end fixedly connected with the box cover plate, a first motor arranged on the frame, and a worm in driving connection with an output shaft of the first motor and used for driving the worm wheel to rotate in a matching manner;

a baffle is arranged at the end part of the rotating shaft, and a photoelectric switch matched with the baffle is arranged on the rotating shaft;

the incubation reaction module is internally provided with a microfluidic disc, and the microfluidic disc is provided with an injection port, a reaction groove and a detection cavity.

3. The chemiluminescence immunoassay analyzer of claim 2, wherein a sliding mechanism is arranged on the box body cover plate, and the sliding mechanism comprises a sliding base arranged on the box body cover plate, a sample adding window arranged on the sliding base and communicated with the interior of the incubation box, a sliding block arranged at the bottom of the sliding base in a sliding way, and a driving mechanism for driving the sliding block to slide back and forth in the sliding base along the transverse direction.

4. The chemiluminescent immunoassay analyzer of claim 3, wherein the driving mechanism comprises a second motor arranged on the sliding base, a rotating wheel in driving connection with an output shaft of the second motor, and a rotating handle connected to the bottom of the rotating wheel;

the sliding block is provided with a longitudinal sliding groove perpendicular to the sliding direction of the sliding block, and the rotating handle is inserted into the sliding groove in a matched mode so as to drive the sliding block to do transverse linear motion.

5. The chemiluminescent immunoassay analyzer of claim 4, wherein the bottom of the sliding base is further provided with a first inductive optical coupler and a second inductive optical coupler, and the first inductive optical coupler and the second inductive optical coupler are longitudinally positioned on the same straight line;

Still seted up on the sliding block be used for with application of sample window complex application of sample breach, be used for with first response opto-coupler complex first opto-coupler hole and be used for with second response opto-coupler complex second opto-coupler hole, first opto-coupler hole and second opto-coupler hole are vertically all not in on the same straight line with horizontal.

6. The chemiluminescent immunoassay analyzer of claim 1, wherein the sample and TIP supply module comprises a base plate slidably disposed on the rack, and a disposable gun head seat, a sample holder, a reagent storage device disposed on the base plate, wherein the sample and TIP supply module further comprises a first barcode gun disposed thereon.

7. The chemiluminescent immunoassay analyzer of claim 1 wherein the pipetting arm module comprises a pipetting arm support, an X-axis module movable in the X-direction on the pipetting arm support, a Z-axis module movable in the Z-direction on the X-axis module, and a pipetting gun disposed on the Z-axis module.

8. The chemiluminescent immunoassay analyzer of claim 7 wherein the X-axis module comprises an X-axis guide rail disposed on the pipetting arm support, an X-axis slide slidably disposed on the X-axis guide rail, and an X-axis motor for driving the X-axis slide to move.

9. The chemiluminescence immunoassay analyzer of claim 8, wherein the Z-axis module comprises a mounting frame connected with the X-axis slider, a Z-axis guide rail arranged on the mounting frame, an upper slider and a lower slider which are slidably arranged on the Z-axis guide rail in sequence from top to bottom, a screw rod arranged on the mounting frame, and a Z-axis motor for driving the screw rod to rotate;

the upper sliding block is provided with a threaded hole matched with the screw rod in a penetrating way, and the lower sliding block is provided with a through hole for the screw rod to pass through; the lower end of the screw rod sequentially penetrates through the threaded hole and the through hole;

and a spring is connected between the upper sliding block and the lower sliding block, and the liquid-transfering gun is arranged on the lower sliding block.

10. The chemiluminescence immunoassay analyzer of claim 9, further comprising a GPRS communication module for accessing the chemiluminescence immunoassay analyzer to the internet of things, realizing the functions of real-time monitoring of the state of the analyzer, maintenance reminding and maintenance alarming, and timely notifying a maintenance engineer and an operation management center to perform processing.

Technical Field

The invention relates to the field of immunoassay, in particular to a chemiluminescence immunoassay analyzer.

Background

Immunological detection is a means for detecting mainly by utilizing a specific reaction between an antigen and an antibody, and is often used for detecting a trace amount of a substance such as a protein or a hormone because a detection signal can be amplified and displayed by using an isotope, an enzyme, a chemiluminescent substance, or the like. From the sixties of the last century, immunoassays are widely used in scientific research and clinical fields. The development of radioimmunoassay from the very beginning to enzyme-linked immunoassays, to chemiluminescent immunoassays which are currently in widespread use, has progressed.

Chemiluminescence immunoassay is a novel labeling immunoassay technology which combines chemiluminescence or bioluminescence with immunoreaction and is used for detecting trace antigens or antibodies. The mechanism of chemiluminescence is that some compounds (luminescent agents or luminescent substrates) can utilize the energy generated by a chemical reaction to raise their product molecules or reaction intermediate molecules to an excited electron state. When this product or intermediate molecule decays to the ground state, energy is released in the form of emitted photons (i.e., light is emitted). Immunoassay is a method for measuring a trace amount of a substance in a specimen by using an antigen-body reaction. The chemiluminescence immunoassay device is widely applied, but the existing chemiluminescence immunoassay device has some defects, such as low examination efficiency, low automation degree, inconvenient operation and the like.

Disclosure of Invention

The technical problem to be solved by the present invention is to provide a chemiluminescence immunoassay analyzer aiming at the defects in the prior art.

In order to solve the technical problems, the invention adopts the technical scheme that: a chemiluminescence immunoassay analyzer comprises a frame, a pipetting arm module, a reagent refrigerating module, a sample and TIP supplying module, an incubation reaction module and a waste bin module, wherein the pipetting arm module, the reagent refrigerating module, the sample and TIP supplying module, the incubation reaction module and the waste bin module are arranged on the frame;

Wherein the pipetting arm module has degrees of freedom in the X-direction and the Z-direction; the reagent refrigerating module is rotatably arranged on the rack and used for refrigerating the reagent; the sample and TIP supply module can move in the Y direction on the rack and is used for providing a disposable pipette TIP, a sample to be detected and a reagent; the incubation reaction module is used for carrying out incubation reaction and is provided with an electric cover opening mechanism.

Preferably, the electric cover opening mechanism comprises a box body cover plate arranged on the incubation box of the incubation reaction module, a supporting seat arranged on the side wall of the incubation box, a rotating shaft pivoted on the supporting seat, a worm wheel fixedly connected on the rotating shaft, an L-shaped connecting rod of which the first end is fixedly connected with the rotating shaft and the second end is fixedly connected with the box body cover plate, a first motor arranged on the rack and a worm which is in driving connection with an output shaft of the first motor and is used for driving the worm wheel to rotate in a matching manner;

a baffle is arranged at the end part of the rotating shaft, and a photoelectric switch matched with the baffle is arranged on the rotating shaft;

the incubation reaction module is internally provided with a microfluidic disc, and the microfluidic disc is provided with an injection port, a reaction groove and a detection cavity.

Preferably, the box body cover plate is provided with a sliding cover mechanism, and the sliding cover mechanism comprises a sliding base arranged on the box body cover plate, a sample adding window arranged on the sliding base and communicated with the interior of the incubation box, a sliding block arranged at the bottom of the sliding base in a sliding manner, and a driving mechanism for driving the sliding block to slide back and forth in the sliding base along the transverse direction.

Preferably, the driving mechanism comprises a second motor arranged on the sliding base, a rotating wheel in driving connection with an output shaft of the second motor, and a rotating handle connected to the bottom of the rotating wheel;

the sliding block is provided with a longitudinal sliding groove perpendicular to the sliding direction of the sliding block, and the rotating handle is inserted into the sliding groove in a matched mode so as to drive the sliding block to do transverse linear motion.

Preferably, the bottom of the sliding base is further provided with a first inductive optical coupler and a second inductive optical coupler, and the first inductive optical coupler and the second inductive optical coupler are longitudinally positioned on the same straight line;

still seted up on the sliding block be used for with application of sample window complex application of sample breach, be used for with first response opto-coupler complex first opto-coupler hole and be used for with second response opto-coupler complex second opto-coupler hole, first opto-coupler hole and second opto-coupler hole are vertically all not in on the same straight line with horizontal.

Preferably, the sample and TIP supply module comprises a bottom plate slidably disposed on the rack, a disposable gun head seat disposed on the bottom plate, a sample holder, and a reagent storage device, and the sample and TIP supply module is further provided with a first barcode gun.

Preferably, the pipetting arm module comprises a pipetting arm support, an X-axis module which can move on the pipetting arm support along the X direction, a Z-axis module which can move on the X-axis module along the Z direction, and a pipetting gun arranged on the Z-axis module.

Preferably, the X-axis module comprises an X-axis guide rail arranged on the pipetting arm support, an X-axis slide block slidably arranged on the X-axis guide rail, and an X-axis motor for driving the X-axis slide block to move.

Preferably, the Z-axis module comprises an installation frame connected with the X-axis slider, a Z-axis guide rail arranged on the installation frame, an upper slider and a lower slider which are sequentially slidably arranged on the Z-axis guide rail from top to bottom, a lead screw arranged on the installation frame, and a Z-axis motor for driving the lead screw to rotate;

the upper sliding block is provided with a threaded hole matched with the screw rod in a penetrating way, and the lower sliding block is provided with a through hole for the screw rod to pass through; the lower end of the screw rod sequentially penetrates through the threaded hole and the through hole;

And a spring is connected between the upper sliding block and the lower sliding block, and the liquid-transfering gun is arranged on the lower sliding block.

Preferably, the chemiluminescence immunoassay analyzer also comprises a GPRS communication module which is used for accessing the chemiluminescence immunoassay analyzer into the Internet of things, realizing the functions of real-time monitoring of the state of the analyzer, maintenance reminding and maintenance alarming, and timely informing a maintenance engineer and an operation management center to process

The invention has the beneficial effects that: the chemiluminescence immunoassay analyzer integrates the functions of liquid transfer, reagent refrigeration, sample and TIP supply, incubation reaction, waste material collection and the like, can greatly improve the efficiency and convenience of chemical analysis, and has good practical use value. The liquid-transfering gun of the invention can realize the electric control of X-direction and Z-direction movement, realize the flexible contact between the liquid-transfering gun and a liquid-transfering object by arranging the spring, ensure the smooth liquid-transfering and protect the liquid-transfering gun and the liquid-transfering object; the invention can realize the addition of the sample under the condition of not opening the cover plate of the box body by arranging the sliding cover mechanism, thereby reducing the interference of the cover plate of the box body on the internal environment of the incubation box when opening. The invention has the advantages of simple structure, high automation degree, convenient use and wide application prospect.

Drawings

FIG. 1 is a schematic view of the structure of a chemiluminescent immunoassay analyzer of the present invention;

FIG. 2 is a schematic view of another aspect of the chemiluminescent immunoassay analyzer of the present invention;

FIG. 3 is a schematic structural diagram of a Z-axis module according to the present invention;

FIG. 4 is a schematic diagram of the structure of an incubation reaction module of the present invention;

FIG. 5 is a schematic structural diagram of a sliding cover mechanism according to the present invention;

FIG. 6 is a structural diagram of the sliding base of the present invention viewed from the bottom;

FIG. 7 is a schematic structural diagram of the slider of the present invention;

FIG. 8 is a schematic structural view of the slide mechanism of the present invention fully closed;

FIG. 9 is a schematic structural view of the slide mechanism of the present invention when fully opened;

FIG. 10 is a schematic diagram of the structure of a microfluidic disk in an incubation reaction module according to the present invention;

fig. 11 is a schematic diagram of a working principle of accessing the chemiluminescence immunoassay analyzer of the present invention to the internet of things in one embodiment.

Description of reference numerals:

1, a frame; 2-pipetting arm module; 3-reagent refrigeration module; 4-sample and TIP supply module; 5-incubation reaction module; 6-waste bin module; 7-a sliding closure mechanism; 20-pipetting arm support; 21-X axis module; 22-Z axis module; 23-a pipette; 30-small holes; 31-a second bar code gun; 32-scanning window; 40-a bottom plate; 41-disposable gun head seat; 42-a sample holder; 43 — reagent storage device; 44-a first bar code gun; 50-incubation box; 51, a box body cover plate; 52-a support seat; 53-a rotating shaft; 54-a worm gear; 55-L-shaped link; 56 — a first electric machine; 57-worm; 58-baffle plate; 59-photoelectric switch; 70-a sliding base; 71-sample application window; 72-a slider; 73-a second motor; 74-a rotating wheel; 75-turning handle; 210-X-axis guide rails; 211 — X axis slide; 212-X axis motor; 220-a mounting frame; 221-Z axis guide; 222-upper slide; 223 — a lower slide block; 224-a screw rod; 225-Z axis motor; 500-microfluidic disc; 700-a first inductive optocoupler; 701-a second inductive optical coupler; 720-longitudinal sliding chute; 721-sample loading gap; 722 — a first light coupling hole; 723 — second light coupling hole.

Detailed Description

The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.

It will be understood that terms such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or groups thereof.

As shown in fig. 1 to 10, the chemiluminescence immunoassay analyzer of the present embodiment comprises a rack 1, and a pipetting arm module 2, a reagent refrigerating module 3, a sample and TIP supply module 4, an incubation reaction module 5, and a waste bin module 6 which are arranged on the rack 1;

wherein the pipetting arm module 2 has degrees of freedom in the X-direction and the Z-direction; the reagent refrigerating module 3 is rotatably arranged on the rack 1 and is used for refrigerating the reagent; the sample and TIP supply module 4 can move on the rack 1 in the Y direction and is used for providing a disposable pipette TIP, a sample to be detected and a reagent; the incubation reaction module 5 is used for carrying out incubation reaction and is provided with an electric cover opening mechanism. The pipetting gun 23 on the pipetting arm module 2 can move in the X direction and the Z direction to suck the disposable pipetting TIPs on the sample and TIP supply module 4, the sample to be tested, the reagent, and the refrigerated reagent in the reagent refrigeration module 3 and add the sample to the incubation reaction module 5 for reaction. The description of the directions in the present invention refers to the coordinate system in fig. 1.

The reagent refrigeration module 3 is used for refrigerating reagents, has a refrigeration function of 2-8 ℃ in the embodiment, provides rotary motion (realized by a conventional motor rotating mechanism), and is matched with the pipetting arm module 2 to finish sampling work of a plurality of reagents. The bin cover on the reagent refrigeration module 3 is provided with a small hole 30, and the reagent refrigeration and the inside can finish the liquid transfer under the condition of not opening the cover. In cooperation with the rotation of the reagent refrigeration module 3, the liquid-transferring gun 23 on the liquid-transferring arm module 2 is used for extending into the small hole 30 to transfer the reagent inside the reagent refrigeration module 3. In a preferred embodiment, the module is further provided with a second barcode gun 31, a scanning window 32 is opened on the side of the reagent refrigeration module 3, and a reagent box inside the reagent refrigeration module 3 is scanned by the second barcode gun 31.

The incubation reaction module 5 has functions of incubation, rotation, centrifugation, measurement, etc., and is a reaction site of the entire instrument.

In one embodiment, the incubation reaction module 5 is provided with a microfluidic disc 500 (fig. 10), a motor, a heating element (not shown), and the like, the microfluidic disc having an injection port, a reaction chamber, and a detection chamber. The motor is used for driving the micro-fluidic disc to rotate, and the heating element is used for heating the micro-fluidic disc; the sample and the reagent are mixed and reacted in the microfluidic disc, and the reaction result is obtained through a detector. Thus, the sample is analyzed to obtain a detection and analysis result.

The waste bin module 6 is responsible for collecting waste pipette tips, waste liquid and the like, and can be collected by adopting disposable garbage bags. In addition, to the customer that the quantity is big, can choose to join in marriage the spout type waste bin, directly slide the discarded object to outside garbage bin in through the spout.

In one embodiment, the overall workflow of the chemiluminescent immunoassay analyzer of the present invention is as follows: the pipetting gun 23 on the pipetting arm module 2 moves to the sample and TIP supply module 4 to suck the disposable pipetting gun heads, then moves to the reagent refrigeration module 3 to suck the refrigerated reagent in the reagent refrigeration module and injects the refrigerated reagent into the microfluidic disc in the incubation reaction module 5; and then replacing the disposable pipette tips (the disposable pipette tips need to be replaced when different reagents are sucked), and respectively injecting the reagents in the reagent storage device 43 and the samples on the sample rack 42 into the microfluidic disc in the incubation reaction module 5 for reaction and detection to complete chemical analysis. When the sample needs to be diluted, the sample is injected into the reagent tube containing the diluent on the sample holder 42 for dilution, and then injected into the microfluidic disk in the incubation reaction module 5.

Reagents in the reagent storage device 43 on the suction pipetting arm module 2 are injected into the sample reagent tubes on the sample rack 42, and other reagents are sucked after the disposable pipette tips are replaced; when the refrigerated reagent in the reagent refrigerating module 3 is sucked, the reagent refrigerating module 3 rotates to rotate the reagent to be sucked to the position below the small hole 30, then the liquid transfer gun 23 is moved to extend into the small hole 30, and the corresponding refrigerated reagent is transferred into the sample reagent tube; after the liquid is added, the sample mixed with the reagent is sucked and injected into the incubation reaction module 5 for reaction and detection, and chemical analysis is completed.

In one embodiment, referring to fig. 4, the electric lid opening mechanism comprises a box body cover plate 51 disposed on the incubation box 50 of the incubation reaction module 5, a support seat 52 disposed on the sidewall of the incubation box 50, a rotating shaft 53 pivoted on the support seat 52, a worm gear 54 fixedly connected to the rotating shaft 53, an L-shaped link 55 fixedly connected to the rotating shaft 53 at a first end and fixedly connected to the box body cover plate 51 at a second end, a first motor 56 disposed on the frame 1, and a worm 57 drivingly connected to an output shaft of the first motor 56 for driving the worm gear 54 to rotate; a baffle plate 58 is arranged at the end part of the rotating shaft 53, and an optoelectronic switch 59 matched with the baffle plate 58 is arranged on the rotating shaft 53.

The motor rotates, the worm gear 54 is driven to rotate through the worm 57, and the L-shaped connecting rod 55 is driven to rotate through the rotating shaft 53, so that the box body cover plate 51 is opened or closed. The photoelectric switch 59 cooperates with the shutter 58 to detect opening and closing of the cassette cover 51. The cover 51 can be electrically opened to facilitate replacement of the components, such as the disk, inside the incubator 50.

In a further preferred embodiment, referring to fig. 5-9, a sliding mechanism 7 is disposed on the box body cover plate 51, and the sliding mechanism 7 comprises a sliding base 70 disposed on the box body cover plate 51, a sample application window 71 opened on the sliding base 70 and communicating with the inside of the incubation box 50, a sliding block 72 slidably disposed on the bottom of the sliding base 70, and a driving mechanism for driving the sliding block 72 to slide back and forth in the sliding base 70 along the transverse direction. The driving mechanism comprises a second motor 73 arranged on the sliding base 70, a rotating wheel 74 in driving connection with an output shaft of the second motor 73, and a rotating handle 75 connected to the bottom of the rotating wheel 74; the sliding block 72 is provided with a longitudinal sliding slot 720 perpendicular to the sliding direction thereof, and the rotating handle 75 is inserted into the sliding slot in a matching manner so as to drive the sliding block 72 to do a transverse linear motion.

The bottom of the sliding base 70 is further provided with a first inductive optical coupler 700 and a second inductive optical coupler 701, and the first inductive optical coupler 700 and the second inductive optical coupler 701 are longitudinally positioned on the same straight line;

the sliding block 72 is further provided with a sample adding gap 721 matched with the sample adding window 71, a first optical coupler hole 722 matched with the first inductive optical coupler 700 and a second optical coupler hole 723 matched with the second inductive optical coupler 701, and the first optical coupler hole 722 and the second optical coupler hole 723 are not in the same straight line in the longitudinal direction and the transverse direction.

In this embodiment, the slide mechanism 7 is used to complete the sample addition without opening the cover plate 51 of the cartridge body, so as to reduce the interference of the cover plate 51 of the cartridge body with the internal environment of the incubation cartridge 50. The specific principle is as follows: the second motor 73 drives the rotating wheel 74 to rotate, the rotating handle 75 at the bottom of the rotating wheel 74 is clamped in the longitudinal sliding groove 720 of the sliding block 72 and limited to slide along the longitudinal sliding groove 720, and the sliding block 72 is limited by the sliding base 70 to slide transversely; when the rotating wheel 74 rotates, the handle 75 moves under the restriction of the longitudinal sliding slot 720, thereby driving the sliding block 72 to slide transversely in the sliding base 70. When the sample loading gap 721 on the sliding block 72 aligns with the sample loading window 71 on the sliding base 70, the sliding cover mechanism 7 is in an open state, and a sample can be loaded into the incubation box 50 through the pipette 23; when the sample loading gap 721 is blocked by other parts of the slide base 70, the slide mechanism 7 is closed.

The sample addition gap 721 is the same size and shape as the sample addition window 71. In a preferred embodiment, the slide mechanism 7 is opened completely, i.e. the loading gap 721 is aligned completely with the loading window 71. If the loading gap 721 is partially aligned with the loading window 71, e.g. only half is open, the disposable pipette tips on the pipette gun 23 will be easily blocked by the slider 72 when they are extended into the loading through the loading window 71. And the sliding cover mechanism 7 needs to be completely closed when being closed, i.e. the sample adding window 71 needs to be completely blocked so as to keep sealing, and ensure the heat preservation inside the incubation box 50 and the isolation from the external environment. In this embodiment, the first inductive optical coupler 700 and the second inductive optical coupler 701 are matched with the first optical coupler hole 722 and the second optical coupler hole 723 to achieve the above functions. The specific principle is as follows: referring to fig. 9, when the sliding cover mechanism 7 is fully opened, the sample loading gap 721 is aligned with the sample loading window 71, and at this time, the first inductive optocoupler 700 is aligned with the first optocoupler hole 722 to generate a trigger signal, which can be assumed to be "on", and the second inductive optocoupler 701 is completely blocked to generate a trigger signal, which can be assumed to be "off"; that is, when the signal of the first inductive optocoupler 700 is "on" and the signal of the second inductive optocoupler 701 is "off", it is determined that the sliding mechanism 7 is completely opened. When the pipetting gun 23 samples, the sliding cover mechanism 7 is completely opened to ensure smooth sample feeding through the sample feeding window 71; after the sample adding is finished, the sliding cover mechanism 7 is completely closed, the sample adding window 71 is closed, and the effects of heat preservation and isolation are achieved.

When the sliding cover mechanism 7 is completely closed, referring to fig. 8, the second inductive optocoupler 701 is opposite to the second optocoupler hole 723, and generates a trigger signal, which may be assumed to be "on", and the first inductive optocoupler 700 is completely blocked, generates a trigger signal, which may be assumed to be "off"; that is, when the signal of the first inductive optocoupler 700 is "off" and the signal of the second inductive optocoupler 701 is "on", it is determined that the sliding mechanism 7 is completely opened. By adopting the structure, the defect of misjudgment caused by the combination of a single inductive optocoupler and an optocoupler hole can be overcome. For example, if only use first response opto-coupler 700 and first opto-coupler hole 722, when half of application of sample breach 721 aligns with application of sample window 71, half of first response opto-coupler 700 is in first opto-coupler hole 722 department, and first response opto-coupler 700 becomes the part and does not cover (becomes the part by covering completely and does not cover), and the partial signal that first response opto-coupler 700 sent also can pass first opto-coupler hole 722 to produce trigger signal, the misjudgement has been aimed at for application of sample breach 721 and application of sample window 71 completely. The principle when judging that sliding closure mechanism 7 closes is the same, when sliding block 72 partially covers application of sample window 71 promptly, first response opto-coupler 700 has also been covered partially (by not covering totally becoming the part and covering), and first response opto-coupler 700 can produce triggering signal, and misjudgment is that application of sample window 71 is covered, and disconnected sliding closure mechanism 7 has closed. In this case, the opening and closing are incomplete, which affects the sample addition and the heat preservation inside the incubator 50 and the isolation from the external environment.

In one embodiment, the sample and TIP supply module 4 includes a bottom plate 40 slidably disposed on the rack 1, a disposable TIP holder 41 disposed on the bottom plate 40, a sample holder 42, and a reagent storage device 43, and the sample and TIP supply module 4 is further provided with a first barcode gun 44. The first bar code finger 44 is used to scan the sample reagent tube on the sample holder 42.

In one embodiment, referring to fig. 3, the pipetting arm module 2 comprises a pipetting arm support 20, an X-axis module 21 movable in the X-direction on the pipetting arm support 20, a Z-axis module 22 movable in the Z-direction on the X-axis module 21, and a pipetting gun 23 arranged on the Z-axis module 22.

The X-axis module 21 includes an X-axis guide rail 210 disposed on the pipetting arm support 20, an X-axis slider 211 slidably disposed on the X-axis guide rail 210, and an X-axis motor 212 for driving the X-axis slider 211 to move.

The Z-axis module 22 includes an installation frame 220 connected to the X-axis slider 211, a Z-axis guide rail 221 disposed on the installation frame 220, an upper slider 222 and a lower slider 223 slidably disposed on the Z-axis guide rail 221 in sequence from top to bottom, a lead screw 224 disposed on the installation frame 220, and a Z-axis motor 225 for driving the lead screw 224 to rotate. In this embodiment, the Z-axis motor 225 is connected to the lead screw 224 through a belt transmission mechanism to drive the lead screw 224 to rotate.

Wherein, a threaded hole (not shown) matched with the screw rod 224 is formed through the upper slide block 222, and a through hole (not shown) for the screw rod 224 to pass through is formed through the lower slide block 223; the lower end of the screw rod 224 sequentially penetrates through the threaded hole and the through hole; a spring (not shown) is connected between the upper slider 222 and the lower slider 223, and the pipette 23 is disposed on the lower slider 223.

The X-axis motor 212 drives the X-axis slide block 211 to move along the X direction, so that the X-direction movement of the Z-axis module 22 and the liquid-transferring gun 23 on the Z-axis module is realized. The Z-axis motor 225 drives the screw rod 224 to rotate through the belt transmission mechanism, and the upper slider 222 in threaded fit with the screw rod 224 slides along the Z-axis direction under the limitation of the Z-axis guide rail 221, so as to drive the lower slider 223 and the pipetting gun 23 thereon to slide along the Z-axis direction, thereby realizing the X-direction and Z-direction movement of the pipetting gun 23. A spring is connected between the upper slide block 222 and the lower slide block 223 for realizing flexible contact between the pipetting gun 23 and the pipetting object. Specifically, for example, when a medicament in a test tube is sampled, a disposable pipette tip on the pipette tip 23 needs to be inserted into the bottom of the test tube, and the test tube or the disposable pipette tip needs to be prevented from being damaged due to rigid collision; at this moment, slider 223 moves down under the upper slide 222 drives, and after disposable pipette tip on the pipette gun 23 contacted the test tube bottom, if upper slide 222 did not stop and can compress the spring when continuing the downstream, disposable pipette tip top no longer moved in the test tube bottom, through the collision of the disposable pipette tip of the buffer memory effect greatly reduced of spring to the test tube, damage was prevented.

In an embodiment, the chemiluminescence immunoassay analyzer is also provided with a GPRS communication module, and can be connected to the internet of things to realize real-time monitoring of the state of the analyzer (such as sample test quantity, temperature, background noise value and the like), maintenance reminding (such as expiration of service life of a transmission belt, maintenance and calibration of a pneumatic pump and the like) and maintenance alarming (such as abnormal temperature, abnormal background noise value and the like), and timely inform a maintenance engineer and an operation management center to process the state, and fig. 11 is a schematic diagram of a working principle of connecting the chemiluminescence immunoassay analyzer to the internet of things.

While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.