阅读说明：本技术 一种医用粘合胶及其制备工艺 (Medical adhesive and preparation process thereof ) 是由 杜翠 于 2020-08-05 设计创作，主要内容包括：本发明公开了一种医用粘合胶及其制备工艺,其主要成分与质量含量为：a-氰基丙烯酸酯56份、二氧化硫0.1份、水性聚氨酯20份、芦荟提取物0.5份、多糖化合物1份、氨基化羧甲基壳聚糖0.2份、柠檬酸钠1份、松香1份、对苯二酚0.2份、聚乙二醇1份、去离子水20份、催化剂、脱水剂与增塑剂。本发明开通过a-氰基丙烯酸酯的聚合速度和对人体组织的影响与烷基的种类有很大关系,随着烷基的长度和侧链碳原子数的增加,使制备后的粘合胶可以强力黏合肌体组织,黏合速度迅速,无毒,对组织反应小,不会造成血栓,同时本制备工艺整体作业流程简单易懂易操作,生产周期短而快速,更好的适用于产品的批量化生产作业。(The invention discloses a medical adhesive and a preparation process thereof, wherein the medical adhesive comprises the following main components in percentage by mass: 56 parts of a-cyanoacrylate, 0.1 part of sulfur dioxide, 20 parts of waterborne polyurethane, 0.5 part of aloe extract, 1 part of polysaccharide compound, 0.2 part of aminated carboxymethyl chitosan, 1 part of sodium citrate, 1 part of rosin, 0.2 part of hydroquinone, 1 part of polyethylene glycol, 20 parts of deionized water, a catalyst, a dehydrating agent and a plasticizer. The invention discloses that the polymerization speed and the influence on human tissues of alpha-cyanoacrylate have great relation with the types of alkyl, the prepared adhesive can strongly adhere the tissues of the human body along with the increase of the length of the alkyl and the number of carbon atoms of a side chain, the adhesion speed is rapid, the adhesive is nontoxic, the reaction on the tissues is small, thrombus can not be caused, and meanwhile, the whole operation flow of the preparation process is simple, easy to understand and operate, the production period is short and rapid, and the preparation process is better suitable for the batch production operation of products.)

1. A medical adhesive and a preparation process thereof, the adhesive comprises the following main components by mass: 56 parts of a-cyanoacrylate, 0.1 part of sulfur dioxide, 20 parts of waterborne polyurethane, 0.5 part of aloe extract, 1 part of polysaccharide compound, 0.2 part of aminated carboxymethyl chitosan, 1 part of sodium citrate, 1 part of rosin, 0.2 part of hydroquinone, 1 part of polyethylene glycol, 20 parts of deionized water, a catalyst, a dehydrating agent and a plasticizer, and is characterized in that: the method comprises the following five steps:

the method comprises the following steps: stirring a-cyanoacrylate, sulfur dioxide and hydroquinone in a reaction kettle A for reaction, and gradually raising the temperature to 85-100 ℃ during stirring;

step two: stirring the waterborne polyurethane in a reaction kettle B for reaction, and gradually raising the temperature to 50-55 ℃ during stirring;

step three: stirring and mixing the aloe extract, polysaccharide compound, aminated carboxymethyl chitosan, sodium citrate, rosin, polyethylene glycol and deionized water in a reaction kettle C, and gradually raising the temperature to 20-30 ℃ while stirring;

step four: the raw material components stirred by the reaction kettle A, the reaction kettle B and the reaction kettle C are intensively mixed and stirred by the reaction kettle D, and a catalyst, a dehydrating agent and a plasticizer are added during stirring, and the temperature is kept at 65-75 ℃;

step five: and sterilizing the prefabricated adhesive after stirring in the reaction kettle D to finish the adhesive finished product.

2. The medical adhesive glue and the preparation process thereof according to claim 1, wherein the adhesive glue comprises the following components: the stirring time of the reaction kettle A is 45-55 minutes; the stirring time of the reaction kettle B is 30-45 minutes; the stirring time of the reaction kettle C is 30-35 minutes; the stirring time of reaction kettle D is 60-80 minutes.

3. The medical adhesive glue and the preparation process thereof according to claim 1, wherein the adhesive glue comprises the following components: the catalyst, the dehydrating agent and the plasticizer respectively account for 0.05-1%, 0.5-4% and 0.5-2% of the raw materials.

4. The medical adhesive glue and the preparation process thereof according to the fifth step of claim 1, wherein the adhesive glue comprises the following components in parts by weight: the sterilization equipment is a steam sterilization pot, the steam pressure in the heating operation is 100-105KPa, and the temperature is 115-125 ℃.

5. The medical adhesive glue and the preparation process thereof according to the sixth step of claim 1, wherein the adhesive glue comprises the following components in parts by weight: the reaction kettle consists of a kettle body, a transmission device, a stirring device, a heating device, a cooling device and a sealing device; the corresponding supporting auxiliary assembly: fractionating column, condenser, water separator, collecting tank, filter, etc.

Technical Field

The invention relates to the technical field of adhesive glue, in particular to medical adhesive glue and a preparation process thereof.

Background

The adhesive can be used for rapidly adhering various materials, so that the adhesive is widely applied to various fields, such as various economic fields of industries such as electric appliances, instruments, machinery, electronic industry and the like, agriculture, civil use and the like, and sometimes needs to adhere organs and tissues in the operation process of the medical field.

In the medical field, the commonly used adhesive glues are classified into three categories: the first kind of adhesive suitable for adhering skin, organ, nerve, muscle, blood vessel and mucous membrane is called soft tissue medical adhesive, and the half of the adhesive is mainly medical alpha-cyano propyl acid ester adhesive and fibrin biological adhesive; the second type of adhesive suitable for bonding and fixing teeth, bones, artificial joints, called hard tissue adhesives, such as polymethylmethacrylate, bone cement, new matrix resins, PUPMA (aromatic polymethacrylic acid polyurethane of maleic anhydride modified bis-GMA resin), and CC-1 type dental adhesives of the adhesive coupling agent 4-META (4-methacryloylethyl trimellitate), etc.; the third kind is medical pressure-sensitive adhesive, basically the same as industrial pressure-sensitive adhesive, the raw materials used are mainly copolymer taking acrylic ester as main component, and are matched with the composition of natural rubber or synthetic rubber and tackifying resin, the medical pressure-sensitive adhesive is used for covering and protecting various surgical incisions and external wounds, such as medical pressure-sensitive adhesive tape, surgical film, incision adhesive tape and the like.

However, in view of the current state of the art, the technical problem to be solved by the present invention is to provide a preparation process of an adhesive with a short preparation period, environmental protection, health and a high polymerization rate, so that the present invention needs to further improve the conventional preparation process of the adhesive to meet the operation requirements.

Disclosure of Invention

The invention aims to provide a medical adhesive and a preparation process thereof, which aim to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

a medical adhesive and a preparation process thereof, the adhesive comprises the following main components by mass: 56 parts of a-cyanoacrylate, 0.1 part of sulfur dioxide, 20 parts of waterborne polyurethane, 0.5 part of aloe extract, 1 part of polysaccharide compound, 0.2 part of aminated carboxymethyl chitosan, 1 part of sodium citrate, 1 part of rosin, 0.2 part of hydroquinone, 1 part of polyethylene glycol, 20 parts of deionized water, a catalyst, a dehydrating agent and a plasticizer, and is characterized in that: the method comprises the following five steps:

the method comprises the following steps: stirring a-cyanoacrylate, sulfur dioxide and hydroquinone in a reaction kettle A for reaction, and gradually raising the temperature to 85-100 ℃ during stirring;

step two: stirring the waterborne polyurethane in a reaction kettle B for reaction, and gradually raising the temperature to 50-55 ℃ during stirring;

step three: stirring and mixing the aloe extract, polysaccharide compound, aminated carboxymethyl chitosan, sodium citrate, rosin, polyethylene glycol and deionized water in a reaction kettle C, and gradually raising the temperature to 20-30 ℃ while stirring;

step four: the raw material components stirred by the reaction kettle A, the reaction kettle B and the reaction kettle C are intensively mixed and stirred by the reaction kettle D, and a catalyst, a dehydrating agent and a plasticizer are added during stirring, and the temperature is kept at 65-75 ℃;

step five: and sterilizing the prefabricated adhesive after stirring in the reaction kettle D to finish the adhesive finished product.

Further, the stirring time of the reaction kettle A is 45-55 minutes; the stirring time of the reaction kettle B is 30-45 minutes; the stirring time of the reaction kettle C is 30-35 minutes; the stirring time of reaction kettle D is 60-80 minutes.

Furthermore, the catalyst, the dehydrating agent and the plasticizer respectively account for 0.05-1%, 0.5-4% and 0.5-2% of the preparation raw materials, and the reaction and mixing of the internal raw materials can be better ensured by setting the component proportion.

Further, the sterilization equipment is a steam sterilization pot, the steam pressure in the heating operation is 100-105KPa, and the temperature is 115-125 ℃.

Further, the reaction kettle consists of a kettle body, a transmission device, a stirring device, a heating device, a cooling device and a sealing device; the corresponding supporting auxiliary assembly: fractionating column, condenser, water separator, collecting tank, filter, etc.

Compared with the prior art, the invention has the beneficial effects that: the medical adhesive and the preparation process thereof have great relationship with the type of alkyl through the polymerization speed of the alpha-cyanoacrylate and the influence on human tissues in the preparation process, and the polymerization speed of the alpha-methyl cyanoacrylate is the fastest; however, with the increase of the length of the alkyl and the number of carbon atoms of the side chain, the polymerization speed is reduced, the irritation is also reduced, so that the prepared adhesive can strongly adhere to the tissue of the organism, the adhesion speed is rapid, the adhesive is nontoxic, the reaction on the tissue is small, the thrombus cannot be caused, meanwhile, the whole operation flow of the preparation process is simple and easy to understand and operate, the production period is short and rapid, and the preparation process is better suitable for the batch production operation of products.

Drawings

FIG. 1 is a schematic flow chart of the preparation method of the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", "front", "rear", "both ends", "one end", "the other end", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "disposed," "connected," and the like are to be construed broadly, such as "connected," which may be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.