阅读说明：本技术 以marcks磷酸化为指标的ad(阿尔茨海默病)、ftld(额颞叶变性症)、als(肌萎缩侧索硬化症)、pd(帕金森病)和dlb(路易小体型痴呆)的检测 (Detection of AD (Alzheimer's disease), FTLD (frontotemporal lobar degeneration), ALS (amyotrophic lateral sclerosis), PD (Parkinson's disease) and DLB (Lewy body type dementia) by MARCKS phosp) 是由 冈泽均 于 2019-03-08 设计创作，主要内容包括：本发明提供一种高灵敏度且高特异性地检测神经系统变性疾病的方法,所述神经系统变性疾病选自人AD(阿尔茨海默病)、FTLD(额颞叶变性症)和ALS(肌萎缩侧索硬化症)。一种检测神经系统变性疾病的方法,所述神经系统变性疾病选自人AD(阿尔茨海默病)、FTLD(额颞叶变性症)和ALS(肌萎缩侧索硬化症),所述方法包括以下步骤：(i)对从受试者采集的样本试样中的46位磷酸化的MARCKS蛋白和非磷酸化MARCKS蛋白进行测定；(ii)由(i)中得到的测定值计算下式表示的DO值；[式1]<Image he="79" wi="700" file="DDA0002674620930000011.GIF" imgContent="drawing" imgFormat="GIF" orientation="portrait" inline="no"></Image>[式中,“pSer46-MARCKS”表示46位磷酸化的MARCKS蛋白的量,“非磷酸化MARCKS”表示非磷酸化MARCKS蛋白的量]；以及,(iii)以DO值为指标检测神经系统变性疾病。(The present invention provides a method for detecting a neurodegenerative disease selected from the group consisting of human AD (alzheimer's disease), FTLD (frontotemporal lobar degeneration) and ALS (amyotrophic lateral sclerosis) with high sensitivity and high specificity. A method for detecting a neurodegenerative disease selected from the group consisting of human AD (Alzheimer's disease),FTLD (frontotemporal lobar degeneration) and ALS (amyotrophic lateral sclerosis), the method comprising the steps of: (i) determining the 46 phosphorylated MARCKS protein and the non-phosphorylated MARCKS protein in a sample taken from the subject; (ii) (ii) calculating a DO value represented by the following formula from the measurement value obtained in (i); [ formula 1] [ in the formula, "pSer 46-MARCKS" represents the amount of MARCKS protein phosphorylated at position 46, "non-phosphorylated MARCKS" represents the amount of non-phosphorylated MARCKS protein](ii) a And, (iii) detecting a neurodegenerative disease using the DO value as an indicator.)