阅读说明：本技术 一种长效抗菌涂层及其在医用导管中的应用方法 (Long-acting antibacterial coating and application method thereof in medical catheter ) 是由 凌岫泉 于 2020-06-01 设计创作，主要内容包括：本发明属于医疗技术领域,具体涉及一种长效抗菌涂层及其在医用导管中的应用方法。一种长效抗菌涂层,包括抗菌剂和包合剂；抗菌剂为奥替尼啶；按照重量份数计算,包合剂包括如下组分：明胶30~58份,卡拉胶20~40份,磷酸钙10~12份,水7~15份和聚乙烯吡咯烷酮0.5~1份。本发明将固定化技术与奥替尼啶有机地结合起来,由于奥替尼啶较长的碳链和较大的分子量,可被有效地锁在包合剂中,不会被体液稀释,始终保持抗菌效能。同时包合剂作为载体固定相,可被均匀地涂布在医用导管中。(The invention belongs to the technical field of medical treatment, and particularly relates to a long-acting antibacterial coating and an application method thereof in a medical catheter. A long-acting antibacterial coating comprises an antibacterial agent and an inclusion agent; the antibacterial agent is octenidine; the inclusion agent comprises the following components in parts by weight: 30-58 parts of gelatin, 20-40 parts of carrageenan, 10-12 parts of calcium phosphate, 7-15 parts of water and 0.5-1 part of polyvinylpyrrolidone. The invention organically combines the immobilization technology with the octenidine, and the octenidine can be effectively locked in the inclusion agent due to the longer carbon chain and the larger molecular weight, can not be diluted by body fluid and always keeps the antibacterial efficiency. Meanwhile, the inclusion agent is used as a carrier stationary phase and can be uniformly coated in the medical catheter.)

1. The long-acting antibacterial coating is characterized by comprising an antibacterial agent and an inclusion agent, wherein the antibacterial agent is octenidine; the inclusion agent comprises the following components in parts by weight: 30-58 parts of gelatin, 20-40 parts of carrageenan, 10-12 parts of calcium phosphate, 7-15 parts of water and 0.5-1 part of polyvinylpyrrolidone.

2. The long-acting antibacterial coating according to claim 1, wherein the mass ratio of octenidine to the inclusion agent is 1: 1-5.

3. The long-acting antibacterial coating according to claim 1, wherein the long-acting antibacterial coating is coated on the inner surface or the outer surface of the polymer medical catheter.

4. The application method of the long-acting antibacterial coating in the medical catheter is characterized by comprising the following operation steps:

s1, pretreating the medical catheter, namely soaking the medical catheter in acetone for 1-3 hours, repeating the steps for 3-4 times, and then placing the medical catheter in an oven for drying;

s2, preparing a coating reagent, mixing the inclusion agent with water, adding the antibacterial agent octenidine, stirring to fully disperse the mixture, and slowly cooling to obtain the coating reagent;

s3, dip-coating the medical catheter, namely soaking the medical catheter processed in the step 1 into the coating reagent obtained in the step S2, uniformly extracting the medical catheter after 30-40 seconds, and air-drying the medical catheter in a drying oven.

5. The method for applying the long-acting antibacterial coating to the medical catheter as claimed in claim 4, wherein in the step 3, a part of the coating reagent is sucked and filled into the medical catheter, the reagent in the catheter is blown out from the straight catheter, after 30-40 seconds, the catheter is completely immersed in the coating reagent, after 30-40 seconds, the catheter is uniformly lifted out, the reagent in the catheter is blown out from the vertical catheter, and the catheter is dried in a box.

6. The method of claim 4 or 5, wherein the temperature of the water in step 2 is 60-80 ℃.

7. The method for applying a long-acting antibacterial coating in a medical catheter as claimed in claim 4 or 5, wherein the stirring time in the step 2 is 3-8 h.

8. The method for applying a long-acting antibacterial coating in a medical catheter as claimed in claim 4 or 5, wherein the temperature of the oven in the step S3 is 60-80 ℃.

9. The method of claim 8, wherein the relative humidity of the oven in step S3 is 45% to 75%.

Technical Field

The invention belongs to the technical field of medical treatment, and particularly relates to a long-acting antibacterial coating and an application method thereof in a medical catheter.

Background

Octenidine (Octenidine, I) is a unique antimicrobial agent. Octenidine exhibits a broad spectrum of antimicrobial efficacy against gram-positive, negative bacteria and fungi. Meanwhile, octenidine has many advantages compared with other antibiotics, such as: 1) is suitable for pregnant women, newborn infants and premature infants; 2) excellent skin and tissue compatibility; 3) no systemic side effects; 4) the long-acting duration lasts for 24 hours; 5) resistance similar to antibiotics does not occur. Octenidine is useful for various rapid topical applications and exerts the necessary antibacterial effect due to its excellent antimicrobial efficacy and tissue compatibility.

Octenidine has a strong advantage in antibacterial action, but once it enters the body with a catheter, it must be diluted by body fluid until its concentration drops below the therapeutic window, and no longer has antibacterial ability. The prior art discloses various polyamide compositions of octenidine, but the molecular structure and spatial conformation of octenidine can be significantly changed through reaction with a polymer, which greatly reduces the antibacterial ability of the modified octenidine.

In view of the above-mentioned shortcomings in the prior art of applying octenidine, the inventor of the present invention has made active research and innovation based on the practical experience and professional knowledge of many years of design and manufacture of such products and by using the theory, in order to create a long-acting antibacterial coating and its application method in medical catheters, which can fully exert the antibacterial effect of octenidine in medical catheters, making it more practical. After continuous research and design and repeated trial production and improvement, the invention with practical value is finally created.

Disclosure of Invention

The first object of the present invention is to provide a long-acting antibacterial coating, which organically combines immobilization technology with octenidine, and because of its longer carbon chain and larger molecular weight, octenidine can be effectively locked in the encapsulating agent, and will not be diluted by body fluid, and the antibacterial efficacy is always maintained. Meanwhile, the inclusion agent is used as a carrier stationary phase, can be uniformly coated in the medical catheter, and has industrial value.

The technical purpose of the invention is realized by the following technical scheme:

the long-acting antibacterial coating provided by the invention comprises an antibacterial agent and an inclusion agent, wherein the antibacterial agent is octenidine; the inclusion agent comprises the following components in parts by weight: 30-58 parts of gelatin, 20-40 parts of carrageenan, 10-12 parts of calcium phosphate, 7-15 parts of water and 0.5-1 part of polyvinylpyrrolidone. The colloid locks the long carbon chain of the octenidine in the molecular gap of the colloid through the molecular association effect, and after the colloid is coated on the surface of the catheter, the concentration of the octenidine is protected from being diluted by body fluid in the using process, so that the octenidine is kept in the concentration range capable of resisting bacteria for a long time, and the aim of prolonging the antibacterial time of the octenidine is fulfilled; wherein the polyvinylpyrrolidone is capable of facilitating the association of the colloid with octenidine.

Furthermore, the mass ratio of the octenidine to the inclusion agent is 1: 1-5.

Furthermore, the long-acting antibacterial coating is coated on the inner surface or the outer surface of the polymer medical catheter.

The invention also aims to provide a preparation method of the long-acting antibacterial coating for the medical catheter, which has the same effect.

The technical effects of the invention are realized by the following technical scheme:

the invention provides an application method of a long-acting antibacterial coating in a medical catheter, which comprises the following operation steps:

s1, pretreating the medical catheter, namely soaking the medical catheter in acetone for 1-3 hours, repeating the steps for 3-4 times, and then placing the medical catheter in an oven for drying;

s2, preparing a coating reagent, mixing the inclusion agent with water, adding the antibacterial agent octenidine, stirring to fully disperse the mixture, and slowly cooling to obtain the coating reagent;

s3, dip-coating the medical catheter, namely soaking the medical catheter processed in the step 1 into the coating reagent obtained in the step S2, uniformly extracting the medical catheter after 30-40 seconds, and air-drying the medical catheter in a drying oven.

Preferably, in step 3, a small amount of coating reagent is sucked and filled into the tube, the tube body is blown out of the tube, after 30-40 seconds, the tube body is completely immersed in the coating reagent, after 30-40 seconds, the tube body is uniformly lifted out, the tube body is blown out of the tube body, and the tube body is air-dried in a box.

Preferably, the temperature of the water in the step 2 is 60-80 ℃.

Preferably, the stirring time in the step 2 is 3-8 h.

Preferably, the temperature of the oven in step S3 is 60 to 80 ℃.

Preferably, the relative humidity of the oven in the step S3 is 45% to 75%.

In conclusion, the invention has the following beneficial effects:

the long-acting antibacterial coating and the medical catheter thereof organically combine the immobilization technology and the octenidine, and the octenidine can be effectively locked in the coating agent and cannot be diluted by body fluid due to the longer carbon chain and the larger molecular weight, so that the antibacterial efficiency is always kept. Meanwhile, the inclusion agent is used as a carrier stationary phase and can be uniformly coated in the medical catheter, so that the medical catheter is convenient to use.

Detailed Description

To further illustrate the technical means and effects of the present invention adopted to achieve the predetermined objects, the embodiments, features and effects of the long-acting antibacterial coating and the application method thereof in the medical catheter according to the present invention are described in detail as follows.