阅读说明：本技术 一种溶栓及预防心血管疾病的中药组合物及其制备方法 (A Chinese medicinal composition for thrombolysis and preventing cardiovascular diseases, and its preparation method ) 是由 丛凤文 于 2021-08-27 设计创作，主要内容包括：本发明公开了一种溶栓及预防心血管疾病的中药组合物,由下列重量配比的原料药制成,川芎、血竭、三七、丹参、生水蛭、郁金、地龙、冰片、罗布麻叶、银杏叶、葛根；本发明采用中草药作为原料,成本低廉,疗效快,作用持久,无毒副作用,具有活血、抗凝、溶栓,行滞散结、祛痰,降压,解毒等功效。适应症状有心脑血管病、高血压、高胆固醇、高血脂等症状。具有活血,抗凝,溶栓,行滞散结,祛瘀,降压,解毒等功效。具有易于制作,成本低廉,治疗效果好的特点。可用于治疗心脑血管病、高血压、高胆固醇、高血脂、冠心病动脉粥样硬化,心绞痛引起心肌阻塞、动脉内膜斑块的形成和膜质沉积、脑动脉硬化,脑心血管狭窄或闭塞、血栓、中风等症。(The invention discloses a traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention, which is prepared from the following raw materials in parts by weight, ligusticum wallichii, dragon's blood, pseudo-ginseng, salvia miltiorrhiza, leech, radix curcumae, earthworm, borneol, dogbane leaf, ginkgo leaf and radix puerariae; the Chinese herbal medicine composition adopts Chinese herbal medicines as raw materials, has the advantages of low cost, quick curative effect, lasting effect and no toxic or side effect, and has the effects of promoting blood circulation, resisting coagulation, dissolving thrombus, activating stagnancy, dissipating stagnation, eliminating phlegm, reducing blood pressure, detoxifying and the like. Is suitable for treating cardiovascular and cerebrovascular diseases, hypertension, hypercholesterolemia, hyperlipemia, etc. Has the effects of promoting blood circulation, resisting coagulation, dissolving thrombus, activating stagnancy, dissipating stagnation, removing blood stasis, reducing blood pressure, detoxifying and the like. Has the characteristics of easy manufacture, low cost and good treatment effect. Can be used for treating cardiovascular and cerebrovascular diseases, hypertension, hypercholesterolemia, hyperlipemia, coronary atherosclerotic heart disease, atherosclerosis, myocardial obstruction caused by angina pectoris, formation of endarterial plaque and membranous deposition, cerebral arteriosclerosis, stenosis or occlusion of cerebral and cardiovascular vessels, thrombosis, apoplexy, etc.)

1. A Chinese medicinal composition for dissolving thrombus and preventing cardiovascular diseases is prepared from rhizoma Ligustici Chuanxiong, sanguis Draxonis, Notoginseng radix, Saviae Miltiorrhizae radix, Hirudo, radix Curcumae, Lumbricus, Borneolum, folium Apocyni Veneti, folium Ginkgo, and radix Puerariae.

2. The traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention according to claim 1, wherein the traditional Chinese medicine composition comprises 30-60 g of ligusticum wallichii, 30-60 g of dragon's blood, 25-50 g of panax notoginseng, 60-100 g of salvia miltiorrhiza, 30-60 g of raw leech, 30-60 g of radix curcumae, 60-100 g of earthworm, 15-40 g of borneol, 50-76g of apocynum venetum leaf, 80-120g of ginkgo leaf and 85-140g of radix puerariae.

3. The traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention according to claim 1, wherein the ligusticum wallichii 50g, dragon's blood 50g, pseudo-ginseng 30 g, salvia miltiorrhiza 80 g, leech 50g, curcuma aromatica 50g, earthworm 80 g, borneol 30 g; 63g of dogbane leaf, 100g of ginkgo leaf and 112g of kudzu root.

4. The traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention according to claim 1, comprising the following steps:

s1, respectively preparing 50g of rhizoma ligustici wallichii, 50g of dragon' S blood, 30 g of pseudo-ginseng, 80 g of salvia miltiorrhiza, 50g of raw leech, 50g of radix curcumae, 80 g of earthworm and 30 g of borneol; 63g of dogbane leaf, 100g of ginkgo leaf and 112g of kudzu root;

s2, adding the Chinese medicinal materials prepared in the step 1) into an extraction tank, and adding an ethanol solution into the extraction tank;

s3, carrying out alcohol extraction on the prepared traditional Chinese medicinal materials in the extraction tank for preset time;

s4, filtering the mixture in the extraction tank, and discarding medicine residues to obtain an alcohol extract;

s5, carrying out reduced pressure concentration on the alcohol extract to obtain a corresponding thick extract, and recovering ethanol; the concentration conditions used were: the temperature is 55-65 ℃, and the vacuum degree is 0.08 MPa; concentrating the alcohol extract until the relative density is 1.20-1.25;

s6, carrying out vacuum drying on the thick extract to obtain a dry extract;

s7, crushing and sieving the dry extract to obtain extract powder;

s8, preparing 85-170 parts of red yeast rice, and sterilizing the prepared red yeast rice by 60Co irradiation;

s9, crushing the sterilized red yeast rice to obtain red yeast rice powder;

s10, uniformly mixing the red yeast rice powder and the extract powder to obtain medicinal powder of the health-care product;

s11, quantitatively packaging the medicinal powder.

5. The traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention according to claim 4, wherein the preparation process further comprises adding 8-25 parts of starch and 1.8-3.5 parts of magnesium stearate into the dry extract powder.

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention and a preparation method thereof.

Background

The cardiovascular and cerebrovascular diseases refer to the diseases of blood supply disturbance of heart and brain tissues caused by cardiovascular and cerebrovascular diseases, and the heart diseases are mainly characterized by coronary heart disease and angina pectoris. Cerebrovascular diseases are mainly manifested as hemorrhagic cerebrovascular diseases and ischemic cerebrovascular diseases. Currently, cardiovascular and cerebrovascular diseases such as cerebral arteriosclerosis, coronary heart disease, angina pectoris, cerebral thrombosis, cerebral infarction, cerebral hemorrhage, etc. have become a frequently encountered disease and a common disease which seriously harm the health of middle-aged and old people. Therefore, prevention and treatment of cardiovascular and cerebrovascular diseases have become a subject of great attention in the social and medical fields. At present, the compound medicine for treating cardiovascular and cerebrovascular diseases has single function, disordered compatibility of traditional Chinese medicines and slow response, while western medicines only adopt a method for expanding blood vessels, can only temporarily relieve the symptoms and root causes, and have high cost, so that patients with cardiovascular and cerebrovascular diseases are difficult to cure.

An effective solution to the problems in the related art has not been proposed yet.

Disclosure of Invention

In order to achieve the above purpose, the invention adopts a technical scheme that the traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention is prepared from the following raw materials of ligusticum wallichii, dragon's blood, pseudo-ginseng, salvia miltiorrhiza, raw leech, radix curcumae, earthworm, borneol, dogbane leaf, ginkgo leaf and radix puerariae in a weight ratio.

Preferably, 30-60 g of ligusticum wallichii, 30-60 g of dragon's blood, 25-50 g of pseudo-ginseng, 60-100 g of salvia miltiorrhiza, 30-60 g of raw leech, 30-60 g of radix curcumae, 60-100 g of earthworm, 15-40 g of borneol, 50-76g of dogbane leaf, 80-120g of ginkgo leaf and 85-140g of kudzu root.

Preferably, 50g of ligusticum wallichii, 50g of dragon's blood, 30 g of pseudo-ginseng, 80 g of salvia miltiorrhiza, 50g of raw leech, 50g of radix curcumae, 80 g of earthworm and 30 g of borneol; 63g of dogbane leaf, 100g of ginkgo leaf and 112g of kudzu root.

A traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention comprises the following steps:

s1, respectively preparing 50g of rhizoma ligustici wallichii, 50g of dragon' S blood, 30 g of pseudo-ginseng, 80 g of salvia miltiorrhiza, 50g of raw leech, 50g of radix curcumae, 80 g of earthworm and 30 g of borneol; 63g of dogbane leaf, 100g of ginkgo leaf and 112g of kudzu root;

s2, adding the Chinese medicinal materials prepared in the step S1 into an extraction tank, and adding an ethanol solution into the extraction tank;

s3, carrying out alcohol extraction on the prepared traditional Chinese medicinal materials in the extraction tank for preset time;

s4, filtering the mixture in the extraction tank, and discarding medicine residues to obtain an alcohol extract;

s5, carrying out reduced pressure concentration on the alcohol extract to obtain a corresponding thick extract, and recovering ethanol; the concentration conditions used were: the temperature is 55-65 ℃, and the vacuum degree is 0.08 MPa; concentrating the alcohol extract until the relative density is 1.20-1.25;

s6, carrying out vacuum drying on the thick extract to obtain a dry extract;

s7, crushing and sieving the dry extract to obtain extract powder;

s8, preparing 85-170 parts of red yeast rice, and sterilizing the prepared red yeast rice by 60Co irradiation;

s9, crushing the sterilized red yeast rice to obtain red yeast rice powder;

s10, uniformly mixing the red yeast rice powder and the extract powder to obtain medicinal powder of the health-care product;

s11, quantitatively packaging the medicinal powder.

Preferably, the preparation process further comprises adding 8-25 parts of starch and 1.8-3.5 parts of magnesium stearate into the dry extract powder;

the medicine of the invention adopts pseudo-ginseng, dragon's blood and rhizoma ligustici wallichii as monarch drugs to promote blood circulation and remove blood stasis, promote qi circulation and relieve pain, dissolve and clear thrombus, expand blood vessels and accelerate blood circulation.

Wherein, notoginseng has wide hemostatic function, can also remove blood stasis, promote blood circulation immediately without moving blood, and stop bleeding without leaving blood stasis, so it is called as "harmonizing nutrient and stopping bleeding, unblocking vessels and removing blood stasis" from Yu catalpa medicinal decomposition "; the dragon's blood is sweet, salty and neutral in taste, enters heart, liver and gallbladder channels, removes stasis and relieves pain, and removes stasis and blood stasis; chuan Xiong is pungent in flavor and warm in nature, enters liver, gallbladder and heart meridians, and activates blood and qi.

The salvia miltiorrhiza, the earthworm and the radix curcumae are used as ministerial drugs, wherein the salvia miltiorrhiza is bitter and slightly cold in taste, enters the heart and liver channels, and activates blood circulation to dissipate blood stasis and relieve pain, and the traditional Chinese medicine is called as 'breaking the old blood and replenishing new blood' in compendium of materia medica, so that the salvia miltiorrhiza can activate middle-jiao and nourish the blood, and can dissipate blood stasis without damaging the blood; the earthworm is salty and cold in nature, enters liver, spleen and lung channels, and has the effects of dredging collaterals and lowering blood pressure; the radix curcumae is pungent and cold in flavor, enters heart and liver channels, promotes qi circulation and relieves depression, prevents blood coagulation and blood stasis, and clears blood and cools blood.

Leech and borneol are used as adjuvant drugs; wherein, the leech is salty and bitter in taste and mild in nature, and has the effects of breaking blood and removing stasis and dysmenorrhea; borneol is pungent and bitter in taste and cold in nature, has the effects of inducing resuscitation with aromatics, restoring consciousness, clearing heat and relieving pain.

Modern pharmacological research proves that: notoginseng radix has effects of resisting thrombi, regulating immunity, promoting hematopoiesis, and dilating blood vessel; saviae Miltiorrhizae radix has effects of tonifying heart, dilating coronary artery, increasing cardiac blood flow, resisting thrombosis, and improving microcirculation; lumbricus has thrombolytic, anticoagulant, antiarrhythmic and tranquilizing effects; the Hirudo has effects of resisting blood coagulation, dissolving thrombus, reducing blood lipid, and increasing heart blood nutrition; folium Apocyni Veneti with effects of clearing away liver fire, suppressing hyperactive liver and calming endogenous wind; folium Ginkgo has effects of promoting blood circulation, removing blood stasis, eliminating turbid pathogen, reducing blood lipid, astringing lung, etc.; pueraria lobata has the effects of invigorating yang, promoting the production of body fluid, promoting blood circulation, dredging collaterals, and strengthening spleen by promoting the production of body fluid.

Has the advantages that: compared with the prior art, the invention has the advantages and positive effects that,

1. the invention selects natural Chinese herbal medicines as raw materials, has no toxicity or harm to human bodies and no side effect.

2. The invention needs no decoction, is convenient to treat and has the effective rate of 96 percent.

3. The formula of the invention accords with the understanding and treatment principle of the pathogenesis of the cardiovascular and cerebrovascular diseases in traditional Chinese medicine, can make people light and not old, make the body smooth and white after long-term administration, maintain the ecological balance in the human body and achieve the purposes of removing diseases and strengthening the body.

Compared with the prior art, the Chinese medicinal composition adopts Chinese medicinal herbs as raw materials, has low cost, quick response, lasting effect and no toxic or side effect, and has the effects of activating blood, resisting coagulation, dissolving thrombus, activating stagnancy, dissipating stagnation, eliminating phlegm, reducing blood pressure, detoxifying and the like. It is suitable for treating cardiovascular and cerebrovascular diseases, hypertension, hypercholesterolemia, hyperlipidemia, coronary atherosclerotic heart disease, atherosclerosis, myocardial obstruction caused by angina pectoris, intimal plaque formation and membranous deposition, cerebral arteriosclerosis, cerebral and cardiovascular stenosis or occlusion, thrombosis, and apoplexy. Has the effects of promoting blood circulation, resisting coagulation, dissolving thrombus, activating stagnancy, dissipating stagnation, removing blood stasis, reducing blood pressure, detoxifying and the like. Has the characteristics of easy manufacture, low cost and good treatment effect. Can be used for treating cardiovascular and cerebrovascular diseases, hypertension, hypercholesterolemia, hyperlipemia, coronary atherosclerotic heart disease, atherosclerosis, myocardial obstruction caused by angina pectoris, formation of endarterial plaque and membranous deposition, cerebral arteriosclerosis, stenosis or occlusion of cerebral and cardiovascular vessels, thrombosis, apoplexy, etc.

Detailed Description

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

Examples

In order that the above objects, features and advantages of the present invention can be more clearly understood, the present invention will be further described with reference to the following examples. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments of the present disclosure.

In the embodiment 1, the scheme provides a traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention, which is prepared from the following raw materials of ligusticum wallichii, dragon's blood, pseudo-ginseng, salvia miltiorrhiza, leech, radix curcumae, earthworm, borneol, dogbane leaf, ginkgo leaf and radix puerariae in a weight ratio.

Further, 30 g of ligusticum wallichii, 30 g of dragon's blood, 25 g of pseudo-ginseng, 60 g of salvia miltiorrhiza, 30 g of raw leech, 30 g of radix curcumae, 60 g of earthworm, 15 g of borneol, 50g of dogbane leaf, 80-120g of ginkgo leaf and 85-140g of kudzuvine root.

Further, 50g of ligusticum wallichii, 50g of dragon's blood, 30 g of pseudo-ginseng, 80 g of salvia miltiorrhiza, 50g of raw leech, 50g of radix curcumae, 80 g of earthworm and 30 g of borneol; 63g of dogbane leaf, 100g of ginkgo leaf and 112g of kudzu root.

In the embodiment 2, the scheme provides a traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention, which is prepared from the following raw materials of ligusticum wallichii, dragon's blood, pseudo-ginseng, salvia miltiorrhiza, leech, radix curcumae, earthworm, borneol, dogbane leaf, ginkgo leaf and radix puerariae in a weight ratio.

Further, 30-60 g of ligusticum wallichii, 30-60 g of dragon's blood, 25-50 g of pseudo-ginseng, 60-100 g of salvia miltiorrhiza, 30-60 g of raw leech, 30-60 g of radix curcumae, 60-100 g of earthworm, 15-40 g of borneol, 50-76g of dogbane leaf, 80-120g of ginkgo leaf and 85-140g of kudzu root.

Further, 50g of ligusticum wallichii, 50g of dragon's blood, 30 g of pseudo-ginseng, 80 g of salvia miltiorrhiza, 50g of raw leech, 50g of radix curcumae, 80 g of earthworm and 30 g of borneol; 63g of dogbane leaf, 100g of ginkgo leaf and 112g of kudzu root.

Embodiment 3 provides a traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention, which is prepared from the following raw materials, by weight, ligusticum wallichii, dragon's blood, pseudo-ginseng, salvia miltiorrhiza, leech, radix curcumae, earthworm, borneol, dogbane leaf, ginkgo leaf and radix puerariae.

Further, 50g of ligusticum wallichii, 50g of dragon's blood, 30 g of pseudo-ginseng, 80 g of salvia miltiorrhiza, 50g of raw leech, 50g of radix curcumae, 80 g of earthworm and 30 g of borneol; 63g of dogbane leaf, 100g of ginkgo leaf and 112g of kudzu root.

In the above-described embodiment of the present invention,

a traditional Chinese medicine composition for thrombolysis and cardiovascular disease prevention comprises the following steps:

s1, respectively preparing 50g of rhizoma ligustici wallichii, 50g of dragon' S blood, 30 g of pseudo-ginseng, 80 g of salvia miltiorrhiza, 50g of raw leech, 50g of radix curcumae, 80 g of earthworm and 30 g of borneol; 63g of dogbane leaf, 100g of ginkgo leaf and 112g of kudzu root;

s2, adding the Chinese medicinal materials prepared in the step 1) into an extraction tank, and adding an ethanol solution into the extraction tank;

s3, carrying out alcohol extraction on the prepared traditional Chinese medicinal materials in the extraction tank for preset time;

s4, filtering the mixture in the extraction tank, and discarding medicine residues to obtain an alcohol extract;

s5, carrying out reduced pressure concentration on the alcohol extract to obtain a corresponding thick extract, and recovering ethanol; the concentration conditions used were: the temperature is 55-65 ℃, and the vacuum degree is 0.08 MPa; concentrating the alcohol extract until the relative density is 1.20-1.25;

s6, carrying out vacuum drying on the thick extract to obtain a dry extract;

s7, crushing and sieving the dry extract to obtain extract powder;

s8, preparing 85-170 parts of red yeast rice, and sterilizing the prepared red yeast rice by 60Co irradiation;

s9, crushing the sterilized red yeast rice to obtain red yeast rice powder;

s10, uniformly mixing the red yeast rice powder and the extract powder to obtain medicinal powder of the health-care product;

s11, quantitatively packaging the medicinal powder.

Furthermore, the preparation process also comprises the step of adding 8-25 parts of starch and 1.8-3.5 parts of magnesium stearate into the dry extract powder.

Selecting 3 groups of people, wherein each group of people comprises 50 people, and each group of experimental people comprises 25 men and 25 women; the corresponding treatment effects of the traditional Chinese medicine composition A, the traditional Chinese medicine composition B and the traditional Chinese medicine composition C respectively prepared by the preparation method are verified, and the following tables are shown:

in the above table, it can be seen that the composition ratio in the third embodiment is selected to achieve the best therapeutic effect when preparing the thrombolytic and cardiovascular disease preventing Chinese medicinal composition.

The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention in other forms, and any person skilled in the art may apply the above modifications or changes to the equivalent embodiments with equivalent changes, without departing from the technical spirit of the present invention, and any simple modification, equivalent change and change made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the technical spirit of the present invention.