阅读说明：本技术 一种减脂组合物及其制备方法 (Fat reducing composition and preparation method thereof ) 是由 李文靖 高丽鹤 苏真真 刘鑫 朱之炜 于 2020-08-12 设计创作，主要内容包括：本发明涉及一种减脂组合物,它包括如下重量份的原料：黑果腺肋花揪果汁粉30～40份、中链甘油三酯微囊粉10～20份、丝瓜粉10～20份、嗜粘蛋白-阿克曼氏菌(Akkermansia muciniphila)3～13份、低聚果糖10～20份；本发明的减脂组合物中链甘油三酯微囊粉与果腺肋花楸果汁粉复配燃烧脂肪、抑制脂肪合成,减少体内脂肪蓄积,协同达到减脂功效；Akk菌与丝瓜粉协同调节肠道菌群,实现控制体重功效；果腺肋花楸果汁粉中的多酚及低聚果糖协同提高Akk菌的丰度,达到减脂功效。综合了5种成分的功效,合理配伍,安全有效,各种成分通过不同途径进行协同作用,加速燃脂,调节肠道菌群,减脂更高效。(The invention relates to a fat-reducing composition, which comprises the following raw materials in parts by weight: 30-40 parts of juice powder of the fructus akebiae, 10-20 parts of medium-chain triglyceride microcapsule powder, 10-20 parts of towel gourd powder, 3-13 parts of mucinous-Akkermansia (Akkermansia muciniphila) and 10-20 parts of fructo-oligosaccharide; the medium-chain triglyceride microcapsule powder and the aronia melanocarpa juice powder in the fat reducing composition are compounded to combust fat, inhibit fat synthesis, reduce fat accumulation in vivo and synergistically achieve the fat reducing effect; akk the bacteria and the towel gourd powder cooperate to regulate intestinal flora and realize the effect of controlling weight; the polyphenol and fructo-oligosaccharide in the Aronia melanocarpa juice powder synergistically improve the abundance of Akk bacteria, so that the fat reducing effect is achieved. The effects of 5 components are integrated, the compatibility is reasonable, the safety and the effectiveness are realized, and various components perform synergistic action through different ways, so that the fat burning is accelerated, the intestinal flora is adjusted, and the fat reduction is more efficient.)

1. A fat-reducing composition comprises the following raw materials in parts by weight: 30-40 parts of black fruit and rib flower fructus fagopyri juice powder, 10-20 parts of medium-chain triglyceride microcapsule powder, 10-20 parts of towel gourd powder, 3-13 parts of mucinous-akkermansia (Akkermansia muciniphila) and 10-20 parts of fructo-oligosaccharide.

2. The fat-reducing composition according to claim 1, comprising the following raw materials in parts by weight: 33-37 parts of juice powder of fructus akebiae, 13-17 parts of medium-chain triglyceride microcapsule powder, 12-18 parts of towel gourd powder, 5-12 parts of mucinous-Akkermansia (Akkermansia muciniphila) and 12-17 parts of fructo-oligosaccharide.

3. The fat-reducing composition according to claim 1, comprising the following raw materials in parts by weight: 36 parts of black fruit gland and rib flower fructus fagopyri powder, 15 parts of medium chain triglyceride microcapsule powder, 15 parts of towel gourd powder, 10 parts of mucinous-Akkermansia (Akkermansia muciniphila) and 16 parts of fructo-oligosaccharide.

4. The fat-reducing composition according to claim 1, wherein the medium-chain triglyceride microcapsule powder contains 70 to 80% by weight of medium-chain triglyceride.

5. A process for preparing a fat reducing composition as claimed in claim 1 comprising the steps of:

(1) sieving fructus Sorbi Pohuashanensis juice powder, medium chain triglyceride microcapsule powder, fructus Luffae powder, and fructo-oligosaccharide with 80 mesh sieve, mixing at a certain proportion to obtain mixture, and adding alcohol into the mixture to obtain soft material; then, granulating through a 20-mesh sieve, drying for 2-3 h at 50-60 ℃ after granulation, and then carrying out granulation and powder sieving to obtain a primary mixture;

(2) and (2) adding the mucinous-Ackermanella (Akkermansia) into the primary mixture obtained in the step (1) according to the proportion, and mixing for 20-25 min to obtain the fat-reducing composition.

6. The method according to claim 5, wherein in the step (1), the alcohol is added in an amount of 5 to 10% by weight based on the weight of the mixture, at a concentration of 40 to 60% by weight.

7. An oral preparation for reducing fat, which is prepared from the fat-reducing composition of claim 1, and is in the form of tablets, capsules or granules.

Technical Field

The invention relates to a fat-reducing composition and a preparation method thereof, belonging to the field of functional foods.

Background

With the development of social civilization, the living standard of people is improved, and the incidence rate of simple obesity is increased year by year. According to the International Association for the Study of Obesity, IASO, it was shown that about 10 million people are overweight worldwide by 2010 (BMI 25-29.9 Kgm)²) More than 4.75 hundred million people are obese (BMI is more than or equal to 30 Kg/m)²)。

Although obesity occurs in association with a variety of factors such as genetic factors, social and environmental factors, psychological factors, etc., obesity occurs directly because more energy is consumed than consumed and the excess energy is stored in the form of fat, thereby causing obesity. Intestinal flora plays an important role in the processes of energy intake, transformation and storage, wherein the flora with absolute dominance in quantity only comprise Firmicutes and Bacteroidetes, and the other flora usually occupies a small proportion. The intestinal flora has specific metabolic efficiency: the host is decomposed into nutrients and provides an energy substrate. In recent years, researches show that the intestinal flora has certain correlation with the onset of obesity, and the mechanism of the intestinal flora relates to a plurality of aspects such as promotion of energy absorption, influence on intestinal mucosa permeability and secretion of appetite regulating factors, induction of endotoxemia, chronic inflammatory response states and the like.

Obesity not only affects the body, causes the imbalance of intestinal flora in the body, but also brings various complications such as diabetes, hypertension, cerebrovascular accident and the like, and harms the health of human beings. With the continuous and deep understanding of obesity hazards, more and more people participate in fat-reducing teams. Diet therapy, exercise therapy, behavior therapy, drug therapy and surgical diet therapy are commonly used as the basic method of obesity therapy. Based on this, a lot of weight-reducing products are produced.

At present, the number of weight-reducing products on the market is large, and 392 health-care foods with the weight-reducing function are found in the data network of the medicine intelligence until 2020.04 months, and a large amount of sports nutritional foods and functional foods which cannot be found are also found. However, the quality of a plurality of weight-losing products is also uneven, some products are expensive, and the weight-losing effect is not realized; some have good weight-losing effect but have obvious side effect; and some people are added with illegal chemical components, so that the body and mind of the people who lose weight are damaged.

CN110800904A discloses a solid beverage composition for effectively controlling body weight and reducing fat, which comprises inulin, fructo-oligosaccharide, whey protein powder, pea protein, navy bean extract, beta-hydroxy-beta-methylbutyrate calcium, l-carnitine, medium chain triglyceride, fruit and vegetable powder or tea powder, and sugar substitute. The effect of improving the intestinal lipid-reducing flora by adding fructo-oligosaccharide and inulin is not obvious.

Disclosure of Invention

Aiming at the defects of the prior art, especially the defects of poor fat reducing effect and obvious side effect of the current fat reducing products, the invention aims to provide a fat reducing composition and a preparation method of the fat reducing composition.

The fat-reducing composition can accelerate fat combustion, inhibit fat synthesis, regulate intestinal flora, synergistically achieve the effect of controlling weight, and is safe and free of side effect.

In order to solve the technical problems, the invention is realized by the following technical scheme:

a fat-reducing composition comprises the following raw materials in parts by weight: 30-40 parts of black fruit and rib flower fructus fagopyri juice powder, 10-20 parts of medium-chain triglyceride microcapsule powder, 10-20 parts of towel gourd powder, 3-13 parts of mucinous-akkermansia (Akkermansia muciniphila) and 10-20 parts of fructo-oligosaccharide.

According to the invention, preferably: the fat-reducing composition comprises the following raw materials in parts by weight: 33-37 parts of juice powder of fructus akebiae, 13-17 parts of medium-chain triglyceride microcapsule powder, 12-18 parts of towel gourd powder, 5-12 parts of mucinous-Akkermansia (Akkermansia muciniphila) and 12-17 parts of fructo-oligosaccharide.

According to the invention, preferably: the fat-reducing composition comprises the following raw materials in parts by weight: 36 parts of black fruit gland and rib flower fructus fagopyri powder, 15 parts of medium chain triglyceride microcapsule powder, 15 parts of towel gourd powder, 10 parts of mucinous-akkermansia (Akkermansia muciniphila) and 16 parts of fructo-oligosaccharide.

According to the invention, the preferable weight content of the medium chain triglyceride in the medium chain triglyceride microcapsule powder is 70-80%.

The preparation method of the fat-reducing composition comprises the following steps:

(1) sieving fructus Sorbi Pohuashanensis juice powder, medium chain triglyceride microcapsule powder, fructus Luffae powder, and fructo-oligosaccharide with 80 mesh sieve, mixing at a certain proportion to obtain mixture, and adding alcohol into the mixture to obtain soft material; then, granulating through a 20-mesh sieve, drying for 2-3 h at 50-60 ℃ after granulation, and then carrying out granulation and powder sieving to obtain a primary mixture;

(2) and (2) adding the mucinous-Ackermanella (Akkermansia muciniphila) into the primary mixture obtained in the step (1) according to the proportion, and mixing for 20-25 min to obtain the fat-reducing composition.

Preferably, in step (1), the alcohol concentration is 40% to 60% and the amount of alcohol added is 5% to 10% by weight of the mixture.

An oral preparation for reducing fat is prepared by adopting the fat-reducing composition, and the dosage form of the oral preparation is tablets, capsules or granules.

The invention has the technical characteristics that:

research shows that obesity is related to increase of systemic oxidative stress, increase of systemic inflammation and the like, and the aronia melanocarpa fruit contains rich nutrient components and bioactive substances: the biological active substances have antioxidant activity, can interfere the process related to oxidative stress, and protect in vitro neutrophils from oxidative damage of obese and non-obese individuals, thereby achieving the effect of losing weight; the nutrition and metabolism center of the medical research institute of Belglad university of Severum takes an abdominal obese person as a research object, and takes a supplement prepared from the aronia melanocarpa juice, and the result shows that the BMI and abdominal circumference of the experimental object are remarkably reduced, and the aronia melanocarpa fruit has the effect of controlling the weight. In addition, the aronia melanocarpa fruit has the highest oxidation resistance in fruits and can protect human cells from oxidation of substances such as free radicals and the like.

The medium-chain triglyceride (MCT) adopted by the invention is the triglyceride composed of fatty acid with 6-12 (also 8-10 or 8-12) carbon atoms. MCT has low energy density, small dependence on bile salt and pancreatin, and easy hydrolysis in intestinal tract, wherein medium-chain fatty acid in hydrolysate is absorbed and combined with albumin, and is directly transported to liver through portal vein; MCT directly enters the mitochondria of the liver cells to be oxidized without depending on carnitine, and the oxidation is rapid and complete, so the MCT is not easy to accumulate in adipose tissues and liver tissues; MCT increases energy expenditure, increases satiety to suppress appetite, thereby reducing weight gain and the volume of fat depots, and helps to reduce visceral fat and subcutaneous fat.

The towel gourd adopted by the invention improves lipid metabolism disorder caused by High Fat Diet (HFD) by inhibiting a signal path of lipid transportation and synthesis of liver, can also improve High Fat Diet (HFD) -induced intestinal flora imbalance of rats, increases the content of short-chain fatty acid and the abundance of related flora, keeps the integrity of intestinal barriers, and relieves the development of obesity, namely the towel gourd improves obesity by regulating the intestinal flora, particularly the enrichment of short-chain fatty acid producing bacteria.

The invention adopts muciniphilic-Ackermanella, which is Akk bacteria for short, and Latin is Akkermansia muciniphila (A. muciniphila), which is an oval gram-negative bacteria, is a resident of human intestinal tracts and accounts for 3-5% of human microbial community. It can grow in the mucus layer of the intestine and "feed" on mucins secreted by the host, thereby colonizing the intestine and protecting it from pathogens by competitive exclusion. Although the Akk bacterium has mucin as an energy source, a number of observations have demonstrated that Akk has a positive regulatory effect on intestinal mucus layer thickness and intestinal barrier integrity. The research shows that: the Akk bacteria level was lower in obese people than in healthy people, and Akk bacteria abundance also had a positive relationship with insulin sensitivity and healthier metabolic state. The abundance of Akk bacteria can be increased by feeding obese mice with polyphenols. Additional studies have shown that: oral administration of live Akk (mouse) can prevent obesity caused by diet by altering adipose tissue metabolism and intestinal permeability, without affecting appetite and dietary habits.

The fructo-oligosaccharide adopted by the invention is not easy to be absorbed by human bodies, can also obviously improve the microbial population ratio in intestinal tracts, is an activated proliferation factor of bifidobacterium in the intestinal tracts, can reduce and inhibit the generation of putrefactive substances in the intestinal tracts, inhibits the growth of harmful bacteria, regulates the balance in the intestinal tracts, and researches show that the Akk bacteria abundance is recovered after the fructo-oligosaccharide is fed to mice.

The invention can bring the following beneficial effects:

1. the bioactive substances of the aronia melanocarpa juice powder in the fat-reducing composition protect in-vitro neutrophils from oxidative damage of obese and non-obese individuals, inhibit fat synthesis and achieve the effect of losing weight; in addition, the Aronia melanocarpa juice powder can reduce the weight of white adipose tissues and the level of leptin, namely, the fat reducing effect is achieved by inhibiting fat synthesis and reducing the level of leptin. The medium chain triglyceride microcapsule powder provides less energy per gram (8.3kcal/9kcal), is not easy to store in fat tissue, helps the body to rapidly enter a fat burning mode, enhances thermogenesis, increases metabolic rate, accelerates fat burning, can increase energy consumption, and achieves the purpose of controlling weight. The luffa powder maintains the integrity of the intestinal barrier and reduces the development of obesity by increasing the content of short chain fatty acids and the abundance of related flora. Akk the strain can regulate intestinal flora by changing adipose tissue metabolism and intestinal permeability, and has effect in reducing fat.

2. The medium-chain triglyceride microcapsule powder and the aronia melanocarpa juice powder in the fat reducing composition are compounded to combust fat, inhibit fat synthesis, reduce fat accumulation in vivo and synergistically achieve the fat reducing effect; akk the bacteria and the towel gourd powder cooperate to regulate intestinal flora and realize the effect of controlling weight; the polyphenol and fructo-oligosaccharide in the Aronia melanocarpa juice powder synergistically improve the abundance of Akk bacteria, so that the fat reducing effect is achieved.

3. The fat-reducing composition integrates the effects of 5 components, is reasonable in compatibility, safe and effective, and has the advantages that various components perform synergistic action through different ways, the fat burning is accelerated, the intestinal flora is adjusted, and the fat reduction is more efficient.

Drawings

FIG. 1 is an analysis chart of relative abundance of main phyla in Experimental example 3.

Detailed Description

The present invention is described in detail with reference to specific examples, which are provided to facilitate the understanding of the technical solutions of the present invention by those skilled in the art, and the implementation or use of the present invention is not limited by the description of the present invention.